germ cell and embryonal neoplasms

Summary

Summary: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.

Top Publications

  1. Korkola J, Houldsworth J, Feldman D, Olshen A, Qin L, Patil S, et al. Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors. J Clin Oncol. 2009;27:5240-7 pubmed publisher
    ..Currently, patients are risk-stratified on the basis of clinical presentation and serum tumor markers. The introduction of molecular markers could improve outcome prediction...
  2. Palmer R, Barbosa Morais N, Gooding E, Muralidhar B, Thornton C, Pett M, et al. Pediatric malignant germ cell tumors show characteristic transcriptome profiles. Cancer Res. 2008;68:4239-47 pubmed publisher
  3. Eckert D, Biermann K, Nettersheim D, Gillis A, Steger K, Jack H, et al. Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. BMC Dev Biol. 2008;8:106 pubmed publisher
    ..This imposes epigenetic modifications leading to transcriptional repression in mouse PGCs enabling them to escape the somatic differentiation program during migration, while expressing markers of pluripotency...
  4. Castillo Avila W, Piulats J, Garcia del Muro X, Vidal A, Condom E, Casanovas O, et al. Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and cisplatin-resistant human testicular germ cell tumors. Clin Cancer Res. 2009;15:3384-95 pubmed publisher
    ..In the present study, we evaluated the effect of sunitinib, CDDP, or the combination of both drugs using an orthotopic model of human testicular GCT...
  5. Sharp D, Carver B, Eggener S, Kondagunta G, Motzer R, Bosl G, et al. Clinical outcome and predictors of survival in late relapse of germ cell tumor. J Clin Oncol. 2008;26:5524-9 pubmed publisher
    ..Late relapse (LR) of germ cell tumor (GCT) is a well recognized entity associated with poor survival. We report on our experience with LR and determine predictors of survival...
  6. Biggs M, Davis M, Eaton D, Weiss N, Barr D, Doody D, et al. Serum organochlorine pesticide residues and risk of testicular germ cell carcinoma: a population-based case-control study. Cancer Epidemiol Biomarkers Prev. 2008;17:2012-8 pubmed publisher
    ..Due to uncertainty regarding how well organochlorine levels measured in adulthood reflect exposures during early life, further research is needed using exposure measurements collected in utero or during infancy...
  7. Rapley E, Turnbull C, Al Olama A, Dermitzakis E, Linger R, Huddart R, et al. A genome-wide association study of testicular germ cell tumor. Nat Genet. 2009;41:807-10 pubmed publisher
    ..05-3.19), P = 10(-31)). KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain the association on chromosome 12. ..
  8. Kanetsky P, Mitra N, Vardhanabhuti S, Li M, Vaughn D, Letrero R, et al. Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet. 2009;41:811-5 pubmed publisher
    ..All of the genotypes were associated with both seminoma and nonseminoma TGCT subtypes. These results demonstrate that common genetic variants affect TGCT risk and implicate KITLG and SPRY4 as genes involved in TGCT susceptibility...
  9. Feldman D, Turkula S, Ginsberg M, Ishill N, Patil S, Carousso M, et al. Phase II trial of sunitinib in patients with relapsed or refractory germ cell tumors. Invest New Drugs. 2010;28:523-8 pubmed publisher
    ..Correlation between sunitinib treatment and tumor marker changes on the 50 mg 4/2 schedule suggest some pathways targeted by sunitinib (ie, angiogenesis) may be important to GCT biology...

More Information

Publications79

  1. Kelly M, Martin L, Alonso M, Altura R. Liver transplant for relapsed undifferentiated embryonal sarcoma in a young child. J Pediatr Surg. 2009;44:e1-3 pubmed publisher
    ..The patient has been in continuous clinical remission for the last 5 years...
  2. Charfi S, Ayadi L, Toumi N, Frikha F, Daoud E, Makni S, et al. Cystic undifferentiated sarcoma of liver in children: a pitfall diagnosis in endemic hydatidosis areas. J Pediatr Surg. 2008;43:E1-4 pubmed publisher
    ..Adjuvant chemotherapy was instituted. She remained well at 11 months of follow-up. Cystic appearance is a usual finding in UES. Differential diagnosis with hydatid cyst may be problematic in endemic hydatidosis areas...
  3. Echevarría M, Fangusaro J, Goldman S. Pediatric central nervous system germ cell tumors: a review. Oncologist. 2008;13:690-9 pubmed publisher
    ..The standard management for CNS GCTs remains controversial. Treatment regimens aimed to improve progression-free and overall survival times are ongoing...
  4. Werbowetski Ogilvie T, Bhatia M. Pluripotent human stem cell lines: what we can learn about cancer initiation. Trends Mol Med. 2008;14:323-32 pubmed publisher
    ..By comparing transformed hPSCs with their normal counterparts, we hope to develop novel cell-specific therapies that selectively target CSCs...
  5. Pachera S, Nishio H, Takahashi Y, Yokoyama Y, Oda K, Ebata T, et al. Undifferentiated embryonal sarcoma of the liver: case report and literature survey. J Hepatobiliary Pancreat Surg. 2008;15:536-44 pubmed publisher
    ..The clinical and histopathological features, as well as the therapeutic choices for adult UES, are described for this patient and in the literature of the past 50 years...
  6. Schrader M, Kempkensteffen C, Christoph F, Hinz S, Weikert S, Lein M, et al. Germ cell tumors of the gonads: a selective review emphasizing problems in drug resistance and current therapy options. Oncology. 2009;76:77-84 pubmed publisher
    ..This review article summarizes theoretical models for the high chemotherapy sensitivity of germ cell tumors and points out new therapeutic prospects...
  7. Hussain S, Ma Y, Palmer D, Hutton P, Cullen M. Biology of testicular germ cell tumors. Expert Rev Anticancer Ther. 2008;8:1659-73 pubmed publisher
    ..Current understanding of the role of genetic and epigenetic factors in the etiology of germ cell tumors and the biochemical mechanisms underlying chemotherapy sensitivity and resistance is discussed in detail in this review...
  8. Lackner J, Koller A, Mazal P, Waldert M, Waldhoer T, Marberger M, et al. The changing distribution of pT stage in testicular germ cell tumours from 1976 to 2005: a single-centre analysis of histopathological reports. BJU Int. 2006;98:747-50 pubmed
  9. Lam D, Gerscovich E, Kuo M, McGahan J. Testicular microlithiasis: our experience of 10 years. J Ultrasound Med. 2007;26:867-73 pubmed
    ..The correlation between TM and testicular malignancies is variable. The purpose of this study was to review our 10-year experience regarding the prevalence of TM and its association with testicular malignancies...
  10. Stang A, Ahrens W, Baumgardt Elms C, Stegmaier C, Merzenich H, de Vrese M, et al. Adolescent milk fat and galactose consumption and testicular germ cell cancer. Cancer Epidemiol Biomarkers Prev. 2006;15:2189-95 pubmed
    ..41-2.86) for each additional 200 g galactose per month during adolescence. Our results suggest that milk fat and/or galactose may explain the association between milk and dairy product consumption and seminomatous testicular cancer...
  11. Hammond S, Zhu R, Youngren K, Lam J, Anderson P, Matin A. Chromosome X modulates incidence of testicular germ cell tumors in Ter mice. Mamm Genome. 2007;18:832-8 pubmed
    ..Thus, our studies provide unambiguous evidence that genetic factors from Chr X modulate the incidence of germ cell tumors in mice with inactivated Dnd1...
  12. Lenze F, Birkfellner T, Lenz P, Hussein K, Langer F, Kreipe H, et al. Undifferentiated embryonal sarcoma of the liver in adults. Cancer. 2008;112:2274-82 pubmed publisher
    ..Data regarding the treatment and survival of adults have not been reviewed comprehensively, and only a few adult patients with UESL have been reported in the literature...
  13. Perrett R, Turnpenny L, Eckert J, O Shea M, Sonne S, Cameron I, et al. The early human germ cell lineage does not express SOX2 during in vivo development or upon in vitro culture. Biol Reprod. 2008;78:852-8 pubmed publisher
    ..The data also provide a new reference point for studies attempting to turn human stem cells into gametes by normal developmental pathways for the treatment of infertility...
  14. Rajpert De Meyts E. Recent advances and future directions in research on testicular germ cell cancer. Int J Androl. 2007;30:192-7 pubmed
  15. Oldenburg J, Martin J, Fossa S. Late relapses of germ cell malignancies: incidence, management, and prognosis. J Clin Oncol. 2006;24:5503-11 pubmed
    ..Referral of late-relapsing patients to high-volume institutions ensures the best chances of cure and enables increasing understanding of tumor biology and the clinical course of these patients...
  16. Shintaku I, Satoh M, Okajima E, Fujimoto H, Kamoto T, Ogawa O, et al. Survival of metastatic germ cell cancer patients assessed by international germ cell consensus classification in Japan. Jpn J Clin Oncol. 2008;38:281-7 pubmed publisher
    ..Since the IGCC classification was based on patients treated between 1975 and 1990, we aimed to investigate whether survival has improved for more recently treated Japanese patients...
  17. Behtash N, Karimi Zarchi M, Modares Gilani M, Ghaemmaghami F, Mousavi A, Ghotbizadeh F. Ovarian carcinoma associated with pregnancy: a clinicopathologic analysis of 23 cases and review of the literature. BMC Pregnancy Childbirth. 2008;8:3 pubmed publisher
    ..The aim of this study was to analyze and describe cases of ovarian cancer in pregnant women treated at our center and to review the literature concerned, and to discuss the rationale for therapy...
  18. Rajpert De Meyts E, Hoei Hansen C. From gonocytes to testicular cancer: the role of impaired gonadal development. Ann N Y Acad Sci. 2007;1120:168-80 pubmed publisher
    ..The effects of environmental factors are likely modulated by genomic variation (polymorphisms), thus explaining the individual susceptibility and population-level differences in the incidence of testicular cancer...
  19. Mueller C, Korde L, Katki H, Rosenberg P, Peters J, Greene M. Constitutional cytogenetic analysis in men with hereditary testicular germ cell tumor: no evidence of disease-related abnormalities. Cancer Epidemiol Biomarkers Prev. 2007;16:2791-4 pubmed
  20. Coffey J, Huddart R, Elliott F, Sohaib S, Parker E, Dudakia D, et al. Testicular microlithiasis as a familial risk factor for testicular germ cell tumour. Br J Cancer. 2007;97:1701-6 pubmed
    ..We suggest that TM is an alternative manifestation of a TGCT susceptibility allele...
  21. Zhu R, Bhattacharya C, Matin A. The role of dead-end in germ-cell tumor development. Ann N Y Acad Sci. 2007;1120:181-6 pubmed
  22. Skakkebaek N, Rajpert De Meyts E, Jørgensen N, Main K, Leffers H, Andersson A, et al. Testicular cancer trends as 'whistle blowers' of testicular developmental problems in populations. Int J Androl. 2007;30:198-204; discussion 204-5 pubmed
  23. Lam M, Heaney J, Youngren K, Kawasoe J, Nadeau J. Trans-generational epistasis between Dnd1Ter and other modifier genes controls susceptibility to testicular germ cell tumors. Hum Mol Genet. 2007;16:2233-40 pubmed
  24. Dalal P, Sohaib S, Huddart R. Imaging of testicular germ cell tumours. Cancer Imaging. 2006;6:124-34 pubmed
    ..This article reviews the role of imaging of testicular germ cell tumours...
  25. McGlynn K, Quraishi S, Graubard B, Weber J, Rubertone M, Erickson R. Persistent organochlorine pesticides and risk of testicular germ cell tumors. J Natl Cancer Inst. 2008;100:663-71 pubmed publisher
    ..Exposure to endocrine-disrupting chemicals, such as persistent organochlorine pesticides, has been suggested to increase the risk of testicular germ cell tumors (TGCTs)...
  26. McGlynn K, Sakoda L, Rubertone M, Sesterhenn I, Lyu C, Graubard B, et al. Body size, dairy consumption, puberty, and risk of testicular germ cell tumors. Am J Epidemiol. 2007;165:355-63 pubmed
    ..As adult height is largely determined in the first 2 years of life, increased attention to events in this interval may help elucidate the etiology of TGCTs...
  27. Skotheim R, Autio R, Lind G, Kraggerud S, Andrews P, Monni O, et al. Novel genomic aberrations in testicular germ cell tumors by array-CGH, and associated gene expression changes. Cell Oncol. 2006;28:315-26 pubmed
    ..Testicular germ cell tumors of adolescent and young adult men (TGCTs) generally have near triploid and complex karyotypes. The actual genes driving the tumorigenesis remain essentially to be identified...
  28. Palmer R, Foster N, Vowler S, Roberts I, Thornton C, Hale J, et al. Malignant germ cell tumours of childhood: new associations of genomic imbalance. Br J Cancer. 2007;96:667-76 pubmed
    ..This data provides new insight into the biology of this under-investigated tumour group and will direct future studies on the significance of specific genetic abnormalities...
  29. Rustin G, Mead G, Stenning S, Vasey P, Aass N, Huddart R, et al. Randomized trial of two or five computed tomography scans in the surveillance of patients with stage I nonseminomatous germ cell tumors of the testis: Medical Research Council Trial TE08, ISRCTN56475197--the National Cancer Research Institute Testis . J Clin Oncol. 2007;25:1310-5 pubmed
    ..A randomized trial of two versus five computed tomography (CT) scans was performed to determine whether the number of scans influenced the proportion of patients relapsing with intermediate- or poor-prognosis disease at relapse...
  30. Goddard N, McIntyre A, Summersgill B, Gilbert D, Kitazawa S, Shipley J. KIT and RAS signalling pathways in testicular germ cell tumours: new data and a review of the literature. Int J Androl. 2007;30:337-48; discussion 349 pubmed
    ..Reducing the expression of KIT in TCam-2 through RNA inhibition resulted in decreased cell viability. Further understanding of KIT and RAS signalling in TGCTs may lead to novel therapeutic approaches for these tumours...
  31. Chieffi P. Molecular targets for the treatment of testicular germ cell tumors. Mini Rev Med Chem. 2007;7:755-9 pubmed
    ..In some cases the clinical trials have confirmed the efficacy of these approaches. Here, we will review the discovered molecular targets for the treatment of testicular germ cell tumors...
  32. Gillis A, Stoop H, Hersmus R, Oosterhuis J, Sun Y, Chen C, et al. High-throughput microRNAome analysis in human germ cell tumours. J Pathol. 2007;213:319-28 pubmed
    ..Moreover, differentiated non-seminomas showed overexpression of discriminating miRNAs. These results support the model that miRNAs are involved in regulating differentiation of stem cells, retained in GCTs...
  33. Lutke Holzik M, Hoekstra H, Sijmons R, Sonneveld D, van der Steege G, Sleijfer D, et al. Re-analysis of the Xq27-Xq28 region suggests a weak association of an X-linked gene with sporadic testicular germ cell tumour without cryptorchidism. Eur J Cancer. 2006;42:1869-74 pubmed
    ..A testicular germ cell tumour (TGCT) predisposing gene has been mapped to the Xq27 region on the X chromosome. These linkage findings remain to be confirmed by other studies...
  34. Bartkova J, Rajpert De Meyts E, Skakkebaek N, Lukas J, Bartek J. DNA damage response in human testes and testicular germ cell tumours: biology and implications for therapy. Int J Androl. 2007;30:282-91; discussion 291 pubmed
  35. de Jong J, Looijenga L. Stem cell marker OCT3/4 in tumor biology and germ cell tumor diagnostics: history and future. Crit Rev Oncog. 2006;12:171-203 pubmed
    ..An overview of the upstream and downstream factors in the OCT3/4 pathway as well as the epigenetic regulation of the gene is summarized and the possible role in oncogenesis considered...
  36. Linger R, Dudakia D, Huddart R, Tucker K, Friedlander M, Phillips K, et al. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors. Genes Chromosomes Cancer. 2008;47:247-52 pubmed
    ..Whether it is disease-causing or not, mutations in DND1 make, at most, a very small contribution to TGCT susceptibility in adults and adolescents...
  37. Katz M, Eggener S. The evolution, controversies, and potential pitfalls of modified retroperitoneal lymph node dissection templates. World J Urol. 2009;27:477-83 pubmed publisher
    ..While modified templates continue to be widely used, larger scale and longer-term studies are essential to fully elucidate their appropriate application and therapeutic efficacy. ..
  38. Liu A, Cheng L, Du J, Peng Y, Allan R, Wei L, et al. Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primary mediastinal germ cell tumors. Am J Surg Pathol. 2010;34:697-706 pubmed publisher
    ..Of these 6 SCMs, SALL4 is the only 1 expressed in YST. These novel SCMs are more sensitive than the currently used markers for mediastinal GCTs. ..
  39. Fakhr I, Khalil E, el Baradie T, Shaalan M, Shalaby L, Nassif S, et al. The role of surgical management in pediatric germ cell tumors (GCTs), NCI case series. J Egypt Natl Canc Inst. 2008;20:70-9 pubmed
    ..Good tumor response can be achieved with surgery and chemotherapy even for advanced stage and metastatic disease. ..
  40. Mai P, Chen B, Tucker K, Friedlander M, Phillips K, Hogg D, et al. Younger age-at-diagnosis for familial malignant testicular germ cell tumor. Fam Cancer. 2009;8:451-6 pubmed publisher
    ..The younger age at diagnosis might be suggestive of a genetic basis for familial TGCT. ..
  41. Aoyama H. Radiation therapy for intracranial germ cell tumors. Prog Neurol Surg. 2009;23:96-105 pubmed publisher
  42. Matei D, Miller A, Monahan P, Gershenson D, Zhao Q, Cella D, et al. Chronic physical effects and health care utilization in long-term ovarian germ cell tumor survivors: a Gynecologic Oncology Group study. J Clin Oncol. 2009;27:4142-9 pubmed publisher
    ..9% of survivors reported being denied health insurance versus 4.4% of controls (P < .001). Although a few sequelae of treatment persist, in general, OGCT survivors enjoy a healthy life comparable to that of controls. ..
  43. Gessi M, Giangaspero F, Lauriola L, Gardiman M, Scheithauer B, Halliday W, et al. Embryonal tumors with abundant neuropil and true rosettes: a distinctive CNS primitive neuroectodermal tumor. Am J Surg Pathol. 2009;33:211-7 pubmed publisher
    ..Performed on 2 cases, cytogenetic analysis revealed extra copies of chromosome 2 in both. We believe that the ETANTR represents a histologically distinctive form of CNS embryonal tumor. ..
  44. Sijmons R, Vos Y, Herkert J, Bos K, Lutke Holzik M, Hoekstra Weebers J, et al. Screening for germline DND1 mutations in testicular cancer patients. Fam Cancer. 2010;9:439-42 pubmed publisher
    ..The role of human DND1 in normal physiology and disease, however, is still virtually unknown and it therefore warrants further research...
  45. Wermann H, Stoop H, Gillis A, Honecker F, van Gurp R, Ammerpohl O, et al. Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance. J Pathol. 2010;221:433-42 pubmed publisher
    ..Among the genes revealing changes, interesting targets were identified: ie demethylation of KLF11, a putative tumour suppressor gene, and hypermethylation of CFLAR, a gene previously described in treatment resistance in GCTs...
  46. Lin C, Liu H. Evidence-based treatment for advanced germ cell tumor of the testis with a case illustration. J Chin Med Assoc. 2010;73:343-52 pubmed publisher
    ..However, the physical and psychological long-term outcomes should be carefully monitored. ..
  47. Lopes L, Macedo C, Pontes E, dos Santos Aguiar S, Mastellaro M, Melaragno R, et al. Cisplatin and etoposide in childhood germ cell tumor: brazilian pediatric oncology society protocol GCT-91. J Clin Oncol. 2009;27:1297-303 pubmed publisher
    ..017]). Thus for selected patients, complex three-agent regimens may not be necessary to achieve long-term survival, even for some patients with advanced disease. ..
  48. Chia V, Li Y, Goldin L, Graubard B, Greene M, Korde L, et al. Risk of cancer in first- and second-degree relatives of testicular germ cell tumor cases and controls. Int J Cancer. 2009;124:952-7 pubmed publisher
    ..69, 95% CI: 0.51-0.94). Thus, this study suggests that there may be aggregation of cancer among families of men diagnosed with TGCT. ..
  49. Riedinger J, Eche N, Chevreau C, Fargeot P. [Germ cell testicular tumors: understanding the kinetics of serum alpha-fetoprotein (AFP) during chemotherapy]. Ann Biol Clin (Paris). 2008;66:523-30 pubmed publisher
    ..The purpose of this work is to present various characteristic profiles of the evolution of serum alpha-fetoprotein during chemotherapy and review the modalities of the dynamic interpretation of this marker. ..
  50. Bats A, Larousserie F, Le Frere Belda M, Metzger U, Lecuru F. [Update on malignant nonepithelial ovarian tumours]. Gynecol Obstet Fertil. 2009;37:627-32 pubmed publisher
    ..We propose an update on recent data in the literature, focusing on management. ..
  51. Asakura K, Izumi Y, Ikeda T, Kimura Y, Horinouchi H, Hayashi Y, et al. Mediastinal germ cell tumor with somatic-type malignancy: report of 5 stage I/II cases. Ann Thorac Surg. 2010;90:1014-6 pubmed publisher
    ..The pretreatment stages were stage I in 2 patients and stage II in 3. All 5 patients received perioperative chemotherapy plus surgical resection, and 4 remain alive without relapse, with a mean follow-up of 60 months. ..
  52. Pavic M, Flechon A, Pivot X, Schell M, Droz J. Report of a young man with three successive curable cancers. Eur J Intern Med. 2008;19:387-8 pubmed publisher
  53. Korkola J, Houldsworth J, Bosl G, Chaganti R. Molecular events in germ cell tumours: linking chromosome-12 gain, acquisition of pluripotency and response to cisplatin. BJU Int. 2009;104:1334-8 pubmed publisher
  54. Moschovi M, Alexiou G, Dastamani A, Stefanaki K, Prodromou N, Hatzigiorgi H, et al. Alpha-fetoprotein secretion in a craniopharyngioma. Are craniopharyngiomas part of the germ cell tumor family?. Acta Neurol Belg. 2010;110:272-5 pubmed
  55. Uglialoro A, Beebe K, Hameed M, Benevenia J. A rare case of intraosseous benign notochordal cell tumor of the coccyx. Orthopedics. 2009;32:445 pubmed publisher
    ..Although chordomas have been well characterized in the surgery, pathology, and radiology literature, the benign notochordal cell tumor is a relative newcomer...
  56. Cao D, Guo S, Allan R, Molberg K, Peng Y. SALL4 is a novel sensitive and specific marker of ovarian primitive germ cell tumors and is particularly useful in distinguishing yolk sac tumor from clear cell carcinoma. Am J Surg Pathol. 2009;33:894-904 pubmed publisher
    ..Our findings indicate that SALL4 is a novel sensitive and specific marker for ovarian primitive GCTs. SALL4 is particularly useful in distinguishing YST from CCC and better than AFP, glypican-3, CK7, and EMA...
  57. Korde L, PremKumar A, Mueller C, Rosenberg P, Soho C, Bratslavsky G, et al. Increased prevalence of testicular microlithiasis in men with familial testicular cancer and their relatives. Br J Cancer. 2008;99:1748-53 pubmed publisher
    ..If proven, this could be clinically important to men in FTGCT families, and may be useful in identifying specific genes involved in FTGCT...
  58. Yu J, Thomson J. Pluripotent stem cell lines. Genes Dev. 2008;22:1987-97 pubmed publisher
    ..Here we review the family of pluripotent cell lines derived from early embryos and from germ cells, and compare them with the more recently described induced pluripotent stem cells...
  59. Kukal K, Dobrovoljac M, Boltshauser E, Ammann R, Grotzer M. Does diagnostic delay result in decreased survival in paediatric brain tumours?. Eur J Pediatr. 2009;168:303-10 pubmed publisher
    ..The effect of tumour biology on survival seems to be dominant and overwhelms any possible opposing effect on survival of a delay in diagnosis...
  60. Tsutsumi S, Yasumoto Y, Ito M. Pediatric multicentric glioma occurring after cranial irradiation. J Clin Neurosci. 2009;16:1086-8 pubmed publisher
    ..These tumors had newly developed within the irradiated field, but were separated in both location and time. Radiation-induced gliomas may develop within a shorter time interval than previously considered...
  61. Chen M, Santos A, Sakuraba R, Lopes C, Gonçalves V, Weltman E, et al. Intensity-modulated and 3D-conformal radiotherapy for whole-ventricular irradiation as compared with conventional whole-brain irradiation in the management of localized central nervous system germ cell tumors. Int J Radiat Oncol Biol Phys. 2010;76:608-14 pubmed publisher
  62. Ellinger J, Albers P, Muller S, von Ruecker A, Bastian P. Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker. BJU Int. 2009;104:48-52 pubmed publisher
    ..To analyse the diagnostic and prognostic value of cell-free mitochondrial (mt)DNA in patients with testicular cancer, as increased levels of cell-free circulating mtDNA have been reported in patients with cancer...
  63. Khatua S, Dhall G, O Neil S, Jubran R, Villablanca J, Marachelian A, et al. Treatment of primary CNS germinomatous germ cell tumors with chemotherapy prior to reduced dose whole ventricular and local boost irradiation. Pediatr Blood Cancer. 2010;55:42-6 pubmed publisher
    ..The purpose of this study was to evaluate a reduced irradiation dose strategy for newly diagnosed primary central nervous system (CNS) germinomas...
  64. Pouessel D, Culine S. [Towards the individualisation of prescriptions in oncology: urogenital cancers]. Bull Cancer. 2008;95:975-8 pubmed publisher
    ..The emergence of targeted therapies and the identification of predictive parameters for treatment efficacy should represent a further step towards the emergence of individualized treatments in the near future...
  65. Diamantopoulos N, Boutis A, Koratzis I, Andreadis C, Galaktidou G, Mouratidou D, et al. Matrix metalloproteinases and proangiogenic factors in testicular germ cell tumors. J BUON. 2010;15:116-21 pubmed
    ..The purpose of this study was to determine the role of matrix metalloproteinases and angiogenic factors in the pathogenesis of testicular germ cell tumors (GCTs)...
  66. Gilbert D, Chandler I, McIntyre A, Goddard N, Gabe R, Huddart R, et al. Clinical and biological significance of CXCL12 and CXCR4 expression in adult testes and germ cell tumours of adults and adolescents. J Pathol. 2009;217:94-102 pubmed publisher
    ..Our observations support a role for CXCL12/CXCR4 in the adult germ cell population and demonstrate pathological function in germ cell tumour development and metastasis that may have clinical utility...
  67. Kollmannsberger C, Honecker F, Bokemeyer C. Pharmacotherapy of relapsed metastatic testicular cancer. Expert Opin Pharmacother. 2008;9:2259-72 pubmed
    ..Patients with metastatic testicular cancer exhibit an excellent prognosis. However, the outcome for patients with relapse after cisplatin-based chemotherapy remains unsatisfactory. Several larger studies have been recently published...
  68. Shinagare A, Jagannathan J, Ramaiya N, Hall M, Van den Abbeele A. Adult extragonadal germ cell tumors. AJR Am J Roentgenol. 2010;195:W274-80 pubmed publisher
    ..The purpose of this article is to describe the key imaging features of primary and metastatic extragonadal germ cell tumors in adults...
  69. Shalaby T, Hiyama E, Grotzer M. Telomere maintenance as therapeutic target in embryonal tumours. Anticancer Agents Med Chem. 2010;10:196-212 pubmed
    ..In this review, we are giving an overview about telomere maintenance in childhood tumours and discussing its potential as a new therapeutic target...
  70. Schuman S, Lambrou N, Robson K, Gluck S, Myriounis N, Pearson J, et al. Pegfilgrastim dosing on same day as myelosuppressive chemotherapy for ovarian or primary peritoneal cancer. J Support Oncol. 2009;7:225-8 pubmed
    ..Administration of pegfilgrastim on the same day as myelosuppressive chemotherapy in patients with ovarian or primary peritoneal cancer may be determined to be a convenient, safe, and effective approach...