choroid neoplasms

Summary

Summary: Tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).

Top Publications

  1. Bell D, Wilson M. Choroidal melanoma: natural history and management options. Cancer Control. 2004;11:296-303 pubmed
    ..Choroidal melanoma is the most common primary malignancy of the eye. Enucleation has been the mainstay of treatment, but new and more effective options have recently been proposed as eye- and vision-sparing alternatives...
  2. McCannel T, Chang M, Burgess B. Multi-year follow-up of fine-needle aspiration biopsy in choroidal melanoma. Ophthalmology. 2012;119:606-10 pubmed publisher
    ..To report the local and systemic follow-up of patients undergoing transscleral intraoperative fine-needle aspiration biopsy (FNAB) at the time of iodine-125 plaque brachytherapy for the treatment of choroidal melanoma...
  3. Damato B, Eleuteri A, Fisher A, Coupland S, Taktak A. Artificial neural networks estimating survival probability after treatment of choroidal melanoma. Ophthalmology. 2008;115:1598-607 pubmed publisher
    ..e., any uveal melanoma involving choroid) and to demonstrate the value of entering age, sex, clinical stage, cytogenetic type, and histologic grade into the predictive model...
  4. Marathe O, Wu J, Lee S, Yu F, Burgess B, Leu M, et al. Ocular response of choroidal melanoma with monosomy 3 versus disomy 3 after iodine-125 brachytherapy. Int J Radiat Oncol Biol Phys. 2011;81:1046-8 pubmed publisher
    ..To report the ocular response of choroidal melanoma with monosomy 3 vs. disomy 3 after (125)I brachytherapy...
  5. Papageorgiou K, Cohen V, Bunce C, Kinsella M, Hungerford J. Predicting local control of choroidal melanomas following ¹??Ru plaque brachytherapy. Br J Ophthalmol. 2011;95:166-70 pubmed publisher
    ..We evaluated the control rate of choroidal melanomas treated with ¹??Ru plaque brachytherapy to identify the risk factors associated with local recurrence and lack of response...
  6. Khurana R, Dibernardo C, Handa J. Improved systemic chemotherapy for metastatic testicular choriocarcinoma can result in excellent prognosis for life and vision. Arch Ophthalmol. 2008;126:1008-9 pubmed publisher
  7. Wilkinson D, Kolar M, Fleming P, Singh A. Dosimetric comparison of 106Ru and 125I plaques for treatment of shallow (<or=5 mm) choroidal melanoma lesions. Br J Radiol. 2008;81:784-9 pubmed publisher
    ..This comparison shows that, for tumours not exceeding 5 mm in thickness, the use of (106)Ru plaques has the potential to reduce the radiation dose to nearby normal structures and possibly lower the risk of radiation-induced visual loss...
  8. George B, Wirostko W, Connor T, Choong N. Complete and durable response of choroid metastasis from non-small cell lung cancer with systemic bevacizumab and chemotherapy. J Thorac Oncol. 2009;4:661-2 pubmed publisher
    ..This case report demonstrates the durable response of choroidal metastasis from non-small cell lung cancer to systemic bevacizumab and chemotherapy...
  9. Correa R, Pera J, Gomez J, Polo A, Gutierrez C, Caminal J, et al. (125)I episcleral plaque brachytherapy in the treatment of choroidal melanoma: a single-institution experience in Spain. Brachytherapy. 2009;8:290-6 pubmed publisher
    ..To analyze the results of episcleral plaque brachytherapy from the Catalan Institute of Oncology in Spain...

More Information

Publications62

  1. Chang M, Kamrava M, Demanes D, Leu M, Agazaryan N, Lamb J, et al. Intraoperative ultrasonography-guided positioning of iodine 125 plaque brachytherapy in the treatment of choroidal melanoma. Ophthalmology. 2012;119:1073-7 pubmed publisher
    ..To report intraoperative ultrasonography-guided positioning of iodine 125 (I(125)) plaques for brachytherapy of choroidal melanoma as a quality improvement measure...
  2. Simsek T, Ozdamar Y, Berker N. Choroidal mass as an initial presentation of lung cancer. Med Oncol. 2008;25:400-2 pubmed publisher
    ..We report a case of a 45-year-old man presenting to our clinic with the complaint of decreased vision in the left eye, which is the initial finding of non-small cell lung-carcinoma...
  3. Boixadera A, Garcia Arumi J, Arumí J, Martinez Castillo V, Encinas J, Elizalde J, et al. Prospective clinical trial evaluating the efficacy of photodynamic therapy for symptomatic circumscribed choroidal hemangioma. Ophthalmology. 2009;116:100-105.e1 pubmed publisher
    ..To evaluate photodynamic therapy (PDT) for symptomatic circumscribed choroidal hemangioma (CCH)...
  4. Sagong M, Lee J, Chang W. Application of intravitreal bevacizumab for circumscribed choroidal hemangioma. Korean J Ophthalmol. 2009;23:127-31 pubmed publisher
    ..No patient showed tumor recurrence. Intravitreal bevacizumab, alone or in combination therapy with PDT, may be a useful alternative for the treatment of symptomatic CCH with subretinal fluid...
  5. Verschueren K, Creutzberg C, Schalij Delfos N, Ketelaars M, Klijsen F, Haeseker B, et al. Long-term outcomes of eye-conserving treatment with Ruthenium(106) brachytherapy for choroidal melanoma. Radiother Oncol. 2010;95:332-8 pubmed publisher
    ..To evaluate long-term outcomes of eye-conserving treatment using Ruthenium-106 plaque brachytherapy with or without transpupillary thermotherapy (TTT) for small to intermediate size choroidal melanomas...
  6. McCannel T, Burgess B, Rao N, Nelson S, Straatsma B. Identification of candidate tumor oncogenes by integrative molecular analysis of choroidal melanoma fine-needle aspiration biopsy specimens. Arch Ophthalmol. 2010;128:1170-7 pubmed publisher
    ..To report integrative molecular analysis of choroidal melanoma fine-needle aspiration biopsy specimens to identify candidate tumor oncogenes...
  7. Al Wassia R, Dal Pra A, Shun K, Shaban A, Corriveau C, Edelstein C, et al. Stereotactic fractionated radiotherapy in the treatment of juxtapapillary choroidal melanoma: the McGill University experience. Int J Radiat Oncol Biol Phys. 2011;81:e455-62 pubmed publisher
    ..To report our experience with linear accelerator-based stereotactic fractionated radiotherapy in the treatment of juxtapapillary choroidal melanoma...
  8. Ascaso F, Castillo J, Garcia F, Cristóbal J, Fuertes A, Artal A. Bilateral choroidal metastases revealing an advanced non-small cell lung cancer. Ann Thorac Surg. 2009;88:1013-5 pubmed publisher
    ..To date, only 10 cases of choroidal metastasis as the first sign of lung carcinoma have been reported. We present a 42-year-old woman with choroidal metastasis as the initial manifestation of an advanced lung carcinoma...
  9. Li H, Shields C, Mashayekhi A, Randolph J, Bailey T, Burnbaum J, et al. Giant choroidal nevus clinical features and natural course in 322 cases. Ophthalmology. 2010;117:324-33 pubmed publisher
    ..Evaluation of clinical features and natural course of giant choroidal nevi (diameter >or=10 mm)...
  10. Dunavoelgyi R, Dieckmann K, Gleiss A, Sacu S, Kircher K, Georgopoulos M, et al. Local tumor control, visual acuity, and survival after hypofractionated stereotactic photon radiotherapy of choroidal melanoma in 212 patients treated between 1997 and 2007. Int J Radiat Oncol Biol Phys. 2011;81:199-205 pubmed publisher
    ..To evaluate long-term local tumor control, visual acuity, and survival after hypofractionated linear accelerator-based stereotactic photon radiotherapy in patients with choroidal melanoma...
  11. McCannel T, Burgess B, Nelson S, Eskin A, Straatsma B. Genomic identification of significant targets in ciliochoroidal melanoma. Invest Ophthalmol Vis Sci. 2011;52:3018-22 pubmed publisher
    ..To identify genomic targets for ciliochoroidal melanoma diagnosis, prognosis, and therapy...
  12. Sagoo M, Shields C, Mashayekhi A, Freire J, Emrich J, Reiff J, et al. Plaque radiotherapy for juxtapapillary choroidal melanoma: tumor control in 650 consecutive cases. Ophthalmology. 2011;118:402-7 pubmed publisher
    ..To evaluate treatment of juxtapapillary choroidal melanoma with plaque radiotherapy and to investigate the role of supplemental transpupillary thermotherapy (TTT)...
  13. Beran T, McCannel T, Stanton A, Straatsma B, Burgess B. Reactions to and desire for prognostic testing in choroidal melanoma patients. J Genet Couns. 2009;18:265-74 pubmed publisher
    ..Prognostic information was important to patients with choroidal melanoma, even in the absence of prophylactic measures which might improve prognosis...
  14. Mensink H, Vaarwater J, Kilic E, Naus N, Mooy N, Luyten G, et al. Chromosome 3 intratumor heterogeneity in uveal melanoma. Invest Ophthalmol Vis Sci. 2009;50:500-4 pubmed publisher
    ..To investigate the presence of focal or diffuse heterogeneity of monosomy 3 in uveal melanoma, by using fluorescence in situ hybridization (FISH)...
  15. Garcia Arumi J, Zapata M, Balaguer O, Fonollosa A, Boixadera A, Martinez Castillo V. Endoresection in high posterior choroidal melanomas: long-term outcome. Br J Ophthalmol. 2008;92:1040-5 pubmed publisher
    ..Eyes with high posterior choroidal melanomas are frequently enucleated because of the potential complications of radiotherapy. The aim of this study was to evaluate the safety and efficacy of endoresection at long-term follow-up...
  16. Narayanan R, Shah V. Intravitreal bevacizumab in the management of choroidal neovascular membrane secondary to choroidal osteoma. Eur J Ophthalmol. 2008;18:466-8 pubmed
    ..To describe a patient with choroidal neovascular membrane (CNVM) secondary to choroidal osteoma treated successfully with intravitreal bevacizumab...
  17. Augsburger J, Correa Z, Trichopoulos N. An alternative hypothesis for observed mortality rates due to metastasis after treatment of choroidal melanomas of different sizes. Trans Am Ophthalmol Soc. 2007;105:54-59; discussion 59-60 pubmed
    ..To propose an alternative hypothesis for the observed differential survival of patients with small, medium, and large choroidal melanomas based on recently uncovered cytogenetic evidence about melanocytic choroidal tumors...
  18. Albert D. The ocular melanoma story. LIII Edward Jackson Memorial Lecture: Part II. Am J Ophthalmol. 1997;123:729-41 pubmed
    ..To trace the evolution and status of our knowledge of choroidal melanoma with regard to the nature, cause, and treatment of this tumor...
  19. Young T, Rao N, Glasgow B, Moral J, Straatsma B. Fluorescent in situ hybridization for monosomy 3 via 30-gauge fine-needle aspiration biopsy of choroidal melanoma in vivo. Ophthalmology. 2007;114:142-6 pubmed
    ..To report the feasibility of intraoperative transscleral fine-needle aspiration biopsy at plaque surgery to obtain cells for monosomy 3 analysis in patients with choroidal melanoma...
  20. Kavanagh M, Pakala S, Hollander D, O Brien J. Choriocarcinoma metastatic to the choroid. Br J Ophthalmol. 2006;90:650-2 pubmed
  21. Schmidt Erfurth U, Michels S, Kusserow C, Jurklies B, Augustin A. Photodynamic therapy for symptomatic choroidal hemangioma: visual and anatomic results. Ophthalmology. 2002;109:2284-94 pubmed
    ..To document the anatomic and functional outcome of photodynamic therapy (PDT) in symptomatic choroidal hemangioma..
  22. Jensen A, Petersen I, Kline R, Stafford S, Schomberg P, Robertson D. Radiation complications and tumor control after 125I plaque brachytherapy for ocular melanoma. Int J Radiat Oncol Biol Phys. 2005;63:101-8 pubmed
    ..To determine the outcome of 125I plaque brachytherapy at our institution and identify the risk factors associated with the development of radiation complications, tumor recurrence, and metastasis...
  23. Huiskamp E, Müskens R, Ballast A, Hooymans J. Diffuse choroidal haemangioma in Sturge-Weber syndrome treated with photodynamic therapy under general anaesthesia. Graefes Arch Clin Exp Ophthalmol. 2005;243:727-30 pubmed
    ..To report the treatment outcome of photodynamic therapy with verteporfin (PDT) for exudative retinal detachment associated with diffuse choroidal haemangioma in Sturge-Weber syndrome...
  24. Michels S, Michels R, Simader C, Schmidt Erfurth U. Verteporfin therapy for choroidal hemangioma: a long-term follow-up. Retina. 2005;25:697-703 pubmed
    ..To document the long-term follow-up of patients with circumscribed choroidal hemangioma who were treated with verteporfin photodynamic therapy (PDT)...
  25. Young T, Burgess B, Rao N, Glasgow B, Straatsma B. Transscleral fine-needle aspiration biopsy of macular choroidal melanoma. Am J Ophthalmol. 2008;145:297-302 pubmed
    ..To report transscleral 30-gauge fine-needle aspiration biopsy (FNAB) for cytology and cytogenetics in eyes with macular choroidal melanoma...
  26. Damato B, Lecuona K. Conservation of eyes with choroidal melanoma by a multimodality approach to treatment: an audit of 1632 patients. Ophthalmology. 2004;111:977-83 pubmed
    ..To report on conservation of eyes with choroidal melanoma with a multimodality approach to treatment...
  27. Damato B, Patel I, Campbell I, Mayles H, Errington R. Local tumor control after 106Ru brachytherapy of choroidal melanoma. Int J Radiat Oncol Biol Phys. 2005;63:385-91 pubmed
    ..To report on local tumor control after (106)Ru brachytherapy for choroidal melanoma...
  28. Levinger S, Merin S, Seigal R, Pe er J. Laser therapy in the management of choroidal breast tumor metastases. Ophthalmic Surg Lasers. 2001;32:294-9 pubmed
    ..To evaluate the potential of laser photocoagulation as a method of treating small metastatic lesions of breast carcinoma in the choroid...
  29. Hawkins B. The Collaborative Ocular Melanoma Study (COMS) randomized trial of pre-enucleation radiation of large choroidal melanoma: IV. Ten-year mortality findings and prognostic factors. COMS report number 24. Am J Ophthalmol. 2004;138:936-51 pubmed
    ..To report rates of death and related outcomes through 10 years after treatment of large choroidal melanoma and to evaluate characteristics of patients and tumors as predictors of relative treatment effectiveness and time to death...
  30. Singh A, Kaiser P, Sears J, Gupta M, Rundle P, Rennie I. Photodynamic therapy of circumscribed choroidal haemangioma. Br J Ophthalmol. 2004;88:1414-8 pubmed
    ..To evaluate efficacy of verteporfin ocular photodynamic therapy (PDT) in treatment of 10 patients with a symptomatic circumscribed choroidal haemangioma...
  31. Donaldson M, Lim L, Harper C, MacKenzie J, G Campbell W. Primary treatment of choroidal amelanotic melanoma with photodynamic therapy. Clin Exp Ophthalmol. 2005;33:548-9 pubmed
    ..The authors report a case of primary treatment of a small choroidal amelanotic melanoma with photodynamic therapy using verteporfin...
  32. Kreusel K, Wiegel T, Stange M, Bornfeld N, Hinkelbein W, Foerster M. Choroidal metastasis in disseminated lung cancer: frequency and risk factors. Am J Ophthalmol. 2002;134:445-7 pubmed
    ..To determine frequency, risk factors, and benefit of a prospective screening for intraocular metastasis in patients with metastatic lung cancer...
  33. Porrini G, Giovannini A, Amato G, Ioni A, Pantanetti M. Photodynamic therapy of circumscribed choroidal hemangioma. Ophthalmology. 2003;110:674-80 pubmed
    ..To evaluate the safety and effectiveness of photodynamic therapy (PDT) in the treatment of symptomatic circumscribed choroidal hemangiomas (CCH) of the posterior pole...
  34. Robertson D. Changing concepts in the management of choroidal melanoma. Am J Ophthalmol. 2003;136:161-70 pubmed
    ..To review emerging information related to changing concepts in the management of choroidal melanoma...
  35. Singh A, Shields J, Shields C, Sato T. Choroidal melanoma metastatic to the contralateral choroid. Am J Ophthalmol. 2001;132:941-3 pubmed
    ..To report metastasis of choroidal melanoma to the contralateral choroid...
  36. Parodi M. Transpupillary thermotherapy for subfoveal choroidal neovascularization associated with choroidal nevus. Am J Ophthalmol. 2004;138:1074-5 pubmed
    ..To describe a patient with classic subfoveal choroidal neovascularization (CNV) associated with choroidal nevus, which was successfully treated using transpupillary thermotherapy...
  37. Sobrin L, Schiffman J, Markoe A, Murray T. Outcomes of iodine 125 plaque radiotherapy after initial observation of suspected small choroidal melanomas: a pilot study. Ophthalmology. 2005;112:1777-83 pubmed
    ..To determine the visual and survival outcomes for patients undergoing plaque radiotherapy of suspected small choroidal melanomas after observation for growth in a pilot study...
  38. Chen J, Lee L, Gass J. Choroidal osteoma: evidence of progression and decalcification over 20 years. Clin Exp Optom. 2006;89:90-4 pubmed
    ..Frequent examinations are recommended for patients with choroidal osteoma, for early detection of a subretinal neovascular membrane and potential treatment with laser photocoagulation...
  39. Melia M, Moy C, Reynolds S, Hayman J, Murray T, Hovland K, et al. Quality of life after iodine 125 brachytherapy vs enucleation for choroidal melanoma: 5-year results from the Collaborative Ocular Melanoma Study: COMS QOLS Report No. 3. Arch Ophthalmol. 2006;124:226-38 pubmed
  40. Ritland J, Eide N, Tausjø J. External beam irradiation therapy for choroidal haemangiomas. Visual and anatomical results after a dose of 20 to 25 Gy. Acta Ophthalmol Scand. 2001;79:184-6 pubmed
    ..To evaluate the visual and anatomic results of radiation therapy in ten patients with choroidal haemangiomas...
  41. Fuss M, Loredo L, Blacharski P, Grove R, Slater J. Proton radiation therapy for medium and large choroidal melanoma: preservation of the eye and its functionality. Int J Radiat Oncol Biol Phys. 2001;49:1053-9 pubmed
    ..Evaluation of efficacy and safety of proton radiation therapy (PRT) for medium- and large-size choroidal melanoma with focus on preservation of the eye and its function...
  42. Shields C, Shields J, Perez N, Singh A, Cater J. Primary transpupillary thermotherapy for small choroidal melanoma in 256 consecutive cases: outcomes and limitations. Ophthalmology. 2002;109:225-34 pubmed
    ..The objective of this report was to evaluate ocular and systemic outcomes after primary transpupillary thermotherapy for choroidal melanoma and to identify the limitations of this treatment method...
  43. Matsuo T, Notohara K. Choroidal schwannoma: immunohistochemical and electron-microscopic study. Ophthalmologica. 2000;214:156-60 pubmed
    ..Histopathological studies showed that the tumor was a schwannoma. At present, we do not have a benchmark for the clinical diagnosis of intraocular schwannoma...
  44. Finger P. Radiation therapy for choroidal melanoma. Surv Ophthalmol. 1997;42:215-32 pubmed
    ..8%) of cases. The purpose of this review is to present the world's experience with radiotherapy for choroidal melanoma, information that will contribute to patient education and informed consent...
  45. Augsburger J, Correa Z, Schneider S, Yassin R, Robinson Smith T, Ehya H, et al. Diagnostic transvitreal fine-needle aspiration biopsy of small melanocytic choroidal tumors in nevus versus melanoma category. Trans Am Ophthalmol Soc. 2002;100:225-32; discussion 232-4 pubmed
    ..To report an experience with fine-needle aspiration biopsy of selected small melanocytic choroidal tumors during the interval from April 13, 1983, through January 19, 2001...
  46. Straatsma B, Diener West M, Caldwell R, Engstrom R. Mortality after deferral of treatment or no treatment for choroidal melanoma. Am J Ophthalmol. 2003;136:47-54 pubmed
  47. Harbour J, Meredith T, Thompson P, Gordon M. Transpupillary thermotherapy versus plaque radiotherapy for suspected choroidal melanomas. Ophthalmology. 2003;110:2207-14; discussion 2215 pubmed
    ..To examine the outcomes and complications of transpupillary thermotherapy for treatment of small choroidal melanomas...
  48. Sarraf D, Jain A, Dubovy S, Kreiger A, Fong D, Paschal J. Mucosa-associated lymphoid tissue lymphoma with intraocular involvement. Retina. 2005;25:94-8 pubmed
    ..To report the clinicopathologic features of a patient with mucosa-associated lymphoid tissue (MALT) lymphoma of the conjunctiva and associated intraocular involvement...
  49. Lee S, Hong J, Choi J, Chung W. Choroidal schwannoma. Acta Ophthalmol Scand. 2005;83:754-6 pubmed
    ..Schwannoma is rarely encountered as an intraocular tumor arising from uveal tract. We describe a case of choroidal schwannoma...
  50. Diener West M, Reynolds S, Agugliaro D, Caldwell R, Cumming K, Earle J, et al. Development of metastatic disease after enrollment in the COMS trials for treatment of choroidal melanoma: Collaborative Ocular Melanoma Study Group Report No. 26. Arch Ophthalmol. 2005;123:1639-43 pubmed
    ..To describe the time between treatment for choroidal melanoma and first diagnosis of metastatic disease, sites of metastasis, treatments for metastasis, and time between diagnosis of metastasis and death...
  51. Madreperla S. Choroidal hemangioma treated with photodynamic therapy using verteporfin. Arch Ophthalmol. 2001;119:1606-10 pubmed
    ..To describe a new treatment for vision loss caused by subretinal fluid associated with circumscribed choroidal hemangioma...
  52. Isager P, Ehlers N, Overgaard J. Prognostic factors for survival after enucleation for choroidal and ciliary body melanomas. Acta Ophthalmol Scand. 2004;82:517-25 pubmed
    ..To evaluate prognostic factors for the survival of patients treated by enucleation for choroidal and ciliary body melanomas...
  53. Shukla D, Ramasamy K. Vitrectomy for circumscribed choroidal hemangioma with exudative retinal detachment refractory to transpupillary thermotherapy. Indian J Ophthalmol. 2007;55:298-9 pubmed
    ..It resulted in complete resolution of the tumor and the detachment. Silicon oil was removed at four months. Visual acuity improved to 20/80 by the last follow-up visit at 10 months without any recurrence...