retinal neoplasms

Summary

Summary: Tumors or cancer of the RETINA.

Top Publications

  1. Woo K, Harbour J. Review of 676 second primary tumors in patients with retinoblastoma: association between age at onset and tumor type. Arch Ophthalmol. 2010;128:865-70 pubmed publisher
    ..To obtain a more accurate understanding of second primary tumors (SPTs) by analyzing a large number of SPTs from the published literature...
  2. Abidi O, Knari S, Sefri H, Charif M, Sénéchal A, Hamel C, et al. Mutational analysis of the RB1 gene in Moroccan patients with retinoblastoma. Mol Vis. 2011;17:3541-7 pubmed
    ..In this study, we screened the RB1 germline mutations in 41 unrelated Moroccan patients with retinoblastoma, 25 heritable cases, and 16 sporadic unilateral cases...
  3. Ali A, Elsheikh S, Elhaj A, Osman N, Abuidris D, Eltayeb E, et al. Clinical presentation and outcome of retinoblastoma among children treated at the National Cancer Institute (NCI) in Gezira, Sudan: a single Institution experience. Ophthalmic Genet. 2011;32:122-5 pubmed publisher
    ..Retinoblastoma (RB) is a rare and unique cancer that affects the eyes of very young children. There are few reports on RB in Sudan...
  4. Munier F, Beck Popovic M, Balmer A, Gaillard M, Bovey E, Binaghi S. Occurrence of sectoral choroidal occlusive vasculopathy and retinal arteriolar embolization after superselective ophthalmic artery chemotherapy for advanced intraocular retinoblastoma. Retina. 2011;31:566-73 pubmed publisher
    ..In this study, we report on the vascular adverse effects observed in our initial cohort of 13 patients...
  5. Bhagat S, Bass J, White S, Qaddoumi I, Wilson M, Wu J, et al. Monitoring carboplatin ototoxicity with distortion-product otoacoustic emissions in children with retinoblastoma. Int J Pediatr Otorhinolaryngol. 2010;74:1156-63 pubmed publisher
  6. Wright K, Qaddoumi I, Patay Z, Gajjar A, Wilson M, Rodriguez Galindo C. Successful treatment of early detected trilateral retinoblastoma using standard infant brain tumor therapy. Pediatr Blood Cancer. 2010;55:570-2 pubmed publisher
    ..Early diagnosis of trilateral retinoblastoma may facilitate the use of less intensive therapeutic approaches and result in excellent outcomes in these patients...
  7. Palazzi M, Stephan C, Brandalise S, Aguiar S. Retinoblastoma diagnosis: a proposal based on the experience of Centro Infantil Boldrini, Brazil. Pediatr Hematol Oncol. 2013;30:379-85 pubmed publisher
  8. Khetan V, Mathur G, Kumar S, Gopal L. Late recurrence of tumor necessitating enucleation in an adult onset retinoblastoma. Ophthalmic Genet. 2013;34:87-9 pubmed publisher
    ..It is important that even after complete regression of the tumor frequent surveillance with fundus examination is necessary to detect early recurrences and to institute prompt management...
  9. Mitra M, Kandalam M, Harilal A, Verma R, Krishnan U, Swaminathan S, et al. EpCAM is a putative stem marker in retinoblastoma and an effective target for T-cell-mediated immunotherapy. Mol Vis. 2012;18:290-308 pubmed
    ..In this study we characterized the EpCAM+ retinoblastoma (RB) cells for their cancer stem-like properties in vitro. Additionally, we targeted RB tumor cells via redirecting T cells using bispecific EpCAM×CD3 antibody...

More Information

Publications61

  1. Dommering C, Marees T, van der Hout A, Imhof S, Meijers Heijboer H, Ringens P, et al. RB1 mutations and second primary malignancies after hereditary retinoblastoma. Fam Cancer. 2012;11:225-33 pubmed publisher
    ..Our findings suggest a genotype-phenotype correlation for second primary cancers of retinoblastoma survivors and may impact on long-term surveillance protocols of patients with hereditary retinoblastoma, if confirmed by future studies...
  2. Vijayakrishnan R, Shields C, Ramasubramanian A, Emrich J, Rosenwasser R, Shields J. Irradiation toxic effects during intra-arterial chemotherapy for retinoblastoma: should we be concerned?. Arch Ophthalmol. 2010;128:1427-31 pubmed publisher
    ..To evaluate irradiation toxic effects from fluoroscopy during intra-arterial chemotherapy for retinoblastoma...
  3. Parulekar M. Retinoblastoma - current treatment and future direction. Early Hum Dev. 2010;86:619-25 pubmed publisher
    ..Lifelong surveillance of mutation carriers is needed due to the risk of second cancers. Newer treatment modalities including intra-arterial chemotherapy have been added to the therapeutic armamentarium in recent years...
  4. Chantada G, Qaddoumi I, Canturk S, Khetan V, Ma Z, Kimani K, et al. Strategies to manage retinoblastoma in developing countries. Pediatr Blood Cancer. 2011;56:341-8 pubmed publisher
    ..Although effective treatment of microscopically extraocular disease improved the outcome, worldwide survival will be increased only by earlier diagnosis and better treatment adherence...
  5. Muen W, Kingston J, Robertson F, Brew S, Sagoo M, Reddy M. Efficacy and complications of super-selective intra-ophthalmic artery melphalan for the treatment of refractory retinoblastoma. Ophthalmology. 2012;119:611-6 pubmed publisher
    ..To report the efficacy of super-selective intra-ophthalmic artery melphalan (IAM) for the treatment of refractory retinoblastoma and any associated complications of this treatment...
  6. Castera L, Sabbagh A, Dehainault C, Michaux D, Mansuet Lupo A, Patillon B, et al. MDM2 as a modifier gene in retinoblastoma. J Natl Cancer Inst. 2010;102:1805-8 pubmed publisher
  7. Pajovic S, Corson T, Spencer C, Dimaras H, Orlic Milacic M, Marchong M, et al. The TAg-RB murine retinoblastoma cell of origin has immunohistochemical features of differentiated Muller glia with progenitor properties. Invest Ophthalmol Vis Sci. 2011;52:7618-24 pubmed publisher
    ..Here, the characteristics of the TAg-RB cell of origin are defined...
  8. Eldebawy E, Patrocinio H, Evans M, Hashem R, Nelson S, Sidi R, et al. Stereotactic radiotherapy as an alternative to plaque brachytherapy in retinoblastoma. Pediatr Blood Cancer. 2010;55:1210-2 pubmed publisher
    ..With advantages and disadvantages to both, SCR should more often be considered in the management of RB because of the more homogeneous dose within the target volume and similar or lower doses to surrounding normal tissues...
  9. Dunkel I, Khakoo Y, Kernan N, Gershon T, Gilheeney S, Lyden D, et al. Intensive multimodality therapy for patients with stage 4a metastatic retinoblastoma. Pediatr Blood Cancer. 2010;55:55-9 pubmed publisher
  10. Abramson D, Marr B, Brodie S, Dunkel I, Palioura S, Gobin Y. Ophthalmic artery chemosurgery for less advanced intraocular retinoblastoma: five year review. PLoS ONE. 2012;7:e34120 pubmed publisher
  11. Peterson E, Elhammady M, Quintero Wolfe S, Murray T, Aziz Sultan M. Selective ophthalmic artery infusion of chemotherapy for advanced intraocular retinoblastoma: initial experience with 17 tumors. J Neurosurg. 2011;114:1603-8 pubmed publisher
    ..The authors' aim in this study was to report on their initial experience with and clinical results for this approach...
  12. Lee N, Berry J, Lee T, Wang A, Honowitz S, Murphree A, et al. Sonoporation enhances chemotherapeutic efficacy in retinoblastoma cells in vitro. Invest Ophthalmol Vis Sci. 2011;52:3868-73 pubmed publisher
    ..To study the ability of ultrasound (US) and microbubbles (MB) to enhance chemotherapeutic efficacy against retinoblastoma Y79 cells in vitro...
  13. Klufas M, Gobin Y, Marr B, Brodie S, Dunkel I, Abramson D. Intra-arterial chemotherapy as a treatment for intraocular retinoblastoma: alternatives to direct ophthalmic artery catheterization. AJNR Am J Neuroradiol. 2012;33:1608-14 pubmed publisher
    ..The purpose of this work was to report our initial results with intra-arterial chemotherapy for intraocular retinoblastoma when delivery of the drug was not via direct catheterization of the OA...
  14. Pradhan M, Ng Y, Strickland A, George P, Raizis A, Warrington J, et al. Role of genetic testing in retinoblastoma management at a tertiary referral centre. Clin Exp Ophthalmol. 2010;38:231-6 pubmed publisher
    ..Retinoblastoma (MIM +180 200) is a malignant neoplasm affecting embryonal retina, associated with mutations in the RB1 gene. This paper investigates the results of RB1 testing in retinoblastoma management in a tertiary referral centre...
  15. Shields C, Fulco E, Arias J, Alarcon C, Pellegrini M, Rishi P, et al. Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy. Eye (Lond). 2013;27:253-64 pubmed publisher
    ..Bilateral retinoblastoma is most often managed with IVC and unilateral retinoblastoma with IAC, but if advanced stage, combination IVC plus IAC or enucleation...
  16. Li L, Li B, Zhang H, Bai S, Wang Y, Zhao B, et al. Lentiviral vector-mediated PAX6 overexpression promotes growth and inhibits apoptosis of human retinoblastoma cells. Invest Ophthalmol Vis Sci. 2011;52:8393-400 pubmed publisher
    ..Apoptosis rates were assessed by TUNEL assay followed by FACS analysis. Using Western blot analysis, the authors measured levels of proteins p53, p21, p27, cdc2, proliferating cell nuclear antigen, and cleaved caspase-3...
  17. Francis J, Kleinerman R, Seddon J, Abramson D. Increased risk of secondary uterine leiomyosarcoma in hereditary retinoblastoma. Gynecol Oncol. 2012;124:254-9 pubmed publisher
    ..As our cohort is followed for a longer period, we discover new second malignancy risks for these patients...
  18. Shields C, Kaliki S, Rojanaporn D, Al Dahmash S, Bianciotto C, Shields J. Intravenous and intra-arterial chemotherapy for retinoblastoma: what have we learned?. Curr Opin Ophthalmol. 2012;23:202-9 pubmed publisher
    ..To review the recent literature on two methods of chemotherapy for retinoblastoma using intravenous versus intra-arterial route...
  19. Patel M, Paulus Y, Gobin Y, Djaballah H, Marr B, Dunkel I, et al. Intra-arterial and oral digoxin therapy for retinoblastoma. Ophthalmic Genet. 2011;32:147-50 pubmed publisher
    ..Preclinical studies demonstrate that cardiac glycosides such as ouabain and digoxin have antitumor effects on retinoblastoma cells in vitro and in a xenograft murine model of retinoblastoma...
  20. Shields C, Bianciotto C, Jabbour P, Ramasubramanian A, Lally S, Griffin G, et al. Intra-arterial chemotherapy for retinoblastoma: report No. 1, control of retinal tumors, subretinal seeds, and vitreous seeds. Arch Ophthalmol. 2011;129:1399-406 pubmed publisher
    ..To describe tumor control following intra-arterial chemotherapy (IAC) for retinoblastoma...
  21. Dunkel I, Chan H, Jubran R, Chantada G, Goldman S, Chintagumpala M, et al. High-dose chemotherapy with autologous hematopoietic stem cell rescue for stage 4B retinoblastoma. Pediatr Blood Cancer. 2010;55:149-52 pubmed publisher
    ..Here we describe a series of eight patients treated with intensive chemotherapy, defined as the intention to include high-dose chemotherapy with autologous hematopoietic stem cell rescue...
  22. Suzuki S, Yamane T, Mohri M, Kaneko A. Selective ophthalmic arterial injection therapy for intraocular retinoblastoma: the long-term prognosis. Ophthalmology. 2011;118:2081-7 pubmed publisher
    ..To report the success rate, adverse events, and long-term prognosis of selective ophthalmic arterial injection (SOAI) therapy for intraocular retinoblastoma...
  23. de Graaf P, Göricke S, Rodjan F, Galluzzi P, Maeder P, Castelijns J, et al. Guidelines for imaging retinoblastoma: imaging principles and MRI standardization. Pediatr Radiol. 2012;42:2-14 pubmed publisher
  24. Dimaras H, Kimani K, Dimba E, Gronsdahl P, White A, Chan H, et al. Retinoblastoma. Lancet. 2012;379:1436-46 pubmed publisher
    ..Most importantly, active participation of survivors and families will ensure that the whole wellbeing of the child is prioritised in any treatment plan...
  25. Chan C, Rubenstein J, Coupland S, Davis J, Harbour J, Johnston P, et al. Primary vitreoretinal lymphoma: a report from an International Primary Central Nervous System Lymphoma Collaborative Group symposium. Oncologist. 2011;16:1589-99 pubmed publisher
    ..Because of the disease rarity, international, multicenter, collaborative efforts are required to better understand the biology and pathogenesis of PVRL as well as to define both diagnostic markers and optimal therapies. ..
  26. Nemeth K, Federico S, Carcaboso A, Shen Y, Schaiquevich P, Zhang J, et al. Subconjunctival carboplatin and systemic topotecan treatment in preclinical models of retinoblastoma. Cancer. 2011;117:421-34 pubmed publisher
    ..However, systemic coadministration of these agents is not ideal, because both agents cause dose-limiting myelosuppression in children...
  27. Gobin Y, Dunkel I, Marr B, Brodie S, Abramson D. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol. 2011;129:732-7 pubmed publisher
    ..Retinoblastoma often presents with advanced intraocular disease and, despite conventional treatment with intravenous chemotherapy and external beam radiation therapy, may still require enucleation...
  28. Ghassemi F, Shields C. Intravitreal melphalan for refractory or recurrent vitreous seeding from retinoblastoma. Arch Ophthalmol. 2012;130:1268-71 pubmed publisher
    ..To evaluate the efficacy and complications of intravitreal chemotherapy for viable vitreous seeding from retinoblastoma...
  29. Mittal R, Al Awadi S, Sahar O, Behbehani A. Ewing's sarcoma as second malignant neoplasm after retinoblastoma: a case report. Med Princ Pract. 2008;17:84-5 pubmed
    ..To report a case of a child with the hereditary form of unilateral retinoblastoma (RB), who developed Ewing's sarcoma of the right fibula 3 years after the enucleation of the right eye...
  30. De Falco G, Giordano A. pRb2/p130: a new candidate for retinoblastoma tumor formation. Oncogene. 2006;25:5333-40 pubmed
  31. Seigel G, Campbell L, Narayan M, Gonzalez Fernandez F. Cancer stem cell characteristics in retinoblastoma. Mol Vis. 2005;11:729-37 pubmed
    ..In this study, we tested the hypothesis that retinoblastomas contain subpopulations of cells that exhibit cancer stem cell properties...
  32. Marees T, van Leeuwen F, Schaapveld M, Imhof S, de Boer M, Kors W, et al. Risk of third malignancies and death after a second malignancy in retinoblastoma survivors. Eur J Cancer. 2010;46:2052-8 pubmed publisher
    ..Treating physicians and patients should be aware of this higher risk...
  33. Chen Y, Lin H, Hsu W, Lee S, Cheng C. Retinoblastoma in Taiwan: incidence and survival characteristics from 1979 to 2003. Eye (Lond). 2010;24:318-22 pubmed publisher
    ..To describe the incidence and survival rate of patients with retinoblastoma in Taiwan over a 25-year period, from 1979 to 2003...
  34. Shields C, Mashayekhi A, Cater J, Shelil A, Ness S, Meadows A, et al. Macular retinoblastoma managed with chemoreduction: analysis of tumor control with or without adjuvant thermotherapy in 68 tumors. Arch Ophthalmol. 2005;123:765-73 pubmed
    ..To evaluate the effectiveness of chemoreduction alone and chemoreduction with thermotherapy for macular retinoblastoma...
  35. Antczak C, Kloepping C, Radu C, Genski T, Müller Kuhrt L, Siems K, et al. Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides. Invest Ophthalmol Vis Sci. 2009;50:3065-73 pubmed publisher
    ..It allows local delivery of relatively high doses of chemotherapy agents while bypassing general blood circulation. For this reason, this study was undertaken to revisit some of the FDA-approved drugs for the treatment of retinoblastoma...
  36. Martin N, Kim J, Abramson D. Fibrin sealant for retinoblastoma: where are we?. J Ocul Pharmacol Ther. 2008;24:433-8 pubmed publisher
    ..This review integrates the recent ophthalmology and pharmaceutics literature on the potential role of fibrin sealants for periocular chemotherapy administration in the treatment of retinoblastoma...
  37. Munier F, Verwey J, Pica A, Balmer A, Zografos L, Abouzeid H, et al. New developments in external beam radiotherapy for retinoblastoma: from lens to normal tissue-sparing techniques. Clin Exp Ophthalmol. 2008;36:78-89 pubmed publisher
    ..Finally, some guidelines are provided regarding indications to modern radiation therapy in patients requiring second-line or salvage treatment for intraocular retinoblastoma, as well as adjuvant therapy for orbital involvement...
  38. Lee C, Bilton S, Famiglietti R, Riley B, Mahajan A, Chang E, et al. Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques?. Int J Radiat Oncol Biol Phys. 2005;63:362-72 pubmed
  39. Kleinerman R, Tucker M, Tarone R, Abramson D, Seddon J, Stovall M, et al. Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol. 2005;23:2272-9 pubmed
    ..We have extended the follow-up of a large cohort of Rb patients for 7 more years to provide new information on the risk of additional cancers after radiotherapy in long-term survivors...
  40. Shields C, Shields J. Basic understanding of current classification and management of retinoblastoma. Curr Opin Ophthalmol. 2006;17:228-34 pubmed
    ..The current classification and management strategies for retinoblastoma are discussed...
  41. Lambert M, Shields C, Meadows A. A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy. Pediatr Blood Cancer. 2008;50:223-6 pubmed
    ..Therefore, since 1994, chemoreduction with vincristine, carboplatin, and etoposide combined with focal treatment, have been used successfully. However, a major concern with the use of carboplatin has been ototoxicity...
  42. Ziemssen F, Voelker M, Inhoffen W, Bartz Schmidt K, Gelisken F. Combined treatment of a juxtapapillary retinal capillary haemangioma with intravitreal bevacizumab and photodynamic therapy. Eye (Lond). 2007;21:1125-6 pubmed
  43. Madhavan J, Coral K, Mallikarjuna K, Corson T, Amit N, Khetan V, et al. High expression of KIF14 in retinoblastoma: association with older age at diagnosis. Invest Ophthalmol Vis Sci. 2007;48:4901-6 pubmed
    ..This study was conducted to quantify the expression of KIF14 in human retinoblastoma tumors and correlate it with disease phenotype...
  44. Mohammed A, Kamel A, Hammad S, Afifi H, El Sanabary Z, El Din M. Constitutional retinoblastoma gene deletion in Egyptian patients. World J Pediatr. 2009;5:222-5 pubmed publisher
    ..Retinoblastoma gene (Rb1) is a tumor suppressor gene that is located on the long arm of chromosome 13 at region 14. This study was to evaluate the constitutional monoallelic Rb1 deletion among retinoblastoma families...
  45. Yu C, Tucker M, Abramson D, Furukawa K, Seddon J, Stovall M, et al. Cause-specific mortality in long-term survivors of retinoblastoma. J Natl Cancer Inst. 2009;101:581-91 pubmed publisher
    ..Radiotherapy further increases the risk of death. Mortality information is limited among long-term survivors who were irradiated for hereditary retinoblastoma...
  46. Macias M, Dean M, Atkinson A, Jiménez Morales S, García Vazquez F, Saldaña Alvarez Y, et al. Spectrum of RB1 gene mutations and loss of heterozygosity in Mexican patients with retinoblastoma: identification of six novel mutations. Cancer Biomark. 2008;4:93-9 pubmed
  47. Lumbroso Le Rouic L, Aerts I, Levy Gabriel C, Dendale R, Sastre X, Esteve M, et al. Conservative treatments of intraocular retinoblastoma. Ophthalmology. 2008;115:1405-10, 1410.e1-2 pubmed publisher
    ..To describe the efficacy of conservative management of retinoblastoma by an association of conservative ocular therapies and chemothermotherapy...
  48. Reisner M, Viégas C, Grazziotin R, Santos Batista D, Carneiro T, Mendonça de Araújo C, et al. Retinoblastoma--comparative analysis of external radiotherapy techniques, including an IMRT technique. Int J Radiat Oncol Biol Phys. 2007;67:933-41 pubmed
    ..The latter was elaborated to evaluate the potential dose reduction in the surrounding tissue, as well as the potential avoidance of subdosage in the ora serrata retinae...
  49. Brisse H, Guesmi M, Aerts I, Sastre Garau X, Savignoni A, Lumbroso Le Rouic L, et al. Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison. Pediatr Radiol. 2007;37:649-56 pubmed
    ..Detection of optic nerve invasion is mandatory in children primarily enucleated for retinoblastoma to ensure a free resection margin...
  50. Odashiro A, Pereira P, de Souza Filho J, Cruess S, Burnier M. Retinoblastoma in an adult: case report and literature review. Can J Ophthalmol. 2005;40:188-91 pubmed
  51. Leng T, Cebulla C, Schefler A, Murray T. Focal periocular carboplatin chemotherapy avoids systemic chemotherapy for unilateral, progressive retinoblastoma. Retina. 2010;30:S66-8 pubmed
    ..The purpose of this study was to report a case of a boy with unilateral, multifocal retinoblastoma who was successfully treated with periocular carboplatin injections for a tumor that progressed despite focal laser ablation...
  52. Lee S, Kim D, Cho J, Koh J, Yoon Y. Inhibitory effect of bevacizumab on the angiogenesis and growth of retinoblastoma. Arch Ophthalmol. 2008;126:953-8 pubmed publisher
    ..To evaluate the potential effect of bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), on the angiogenesis and tumor growth of retinoblastoma in vitro and in vivo...