eye neoplasms

Summary

Summary: Tumors or cancer of the EYE.

Top Publications

  1. Shousha M, Karp C, Canto A, Hodson K, Oellers P, Kao A, et al. Diagnosis of ocular surface lesions using ultra-high-resolution optical coherence tomography. Ophthalmology. 2013;120:883-91 pubmed publisher
    ..To assess the use of ultra-high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions...
  2. Chauhan S, Sen S, Sharma A, Dar L, Kashyap S, Kumar P, et al. Human papillomavirus: a predictor of better survival in ocular surface squamous neoplasia patients. Br J Ophthalmol. 2012;96:1517-21 pubmed publisher
    ..In this study the presence and significance of HPV in OSSN and its correlation with p16(INK4a) immunoexpression was determined...
  3. Di Girolamo N. Association of human papilloma virus with pterygia and ocular-surface squamous neoplasia. Eye (Lond). 2012;26:202-11 pubmed publisher
    ..Currently, over 60 million people worldwide have been immunized with HPV vaccines, but any effect on pterygium and OSSN development may not be known for some time as these lesions can evolve over decades or occur in older individuals...
  4. Yousef Y, Finger P. Squamous carcinoma and dysplasia of the conjunctiva and cornea: an analysis of 101 cases. Ophthalmology. 2012;119:233-40 pubmed publisher
    ..To evaluate clinical and histopathologic factors of squamous conjunctival neoplasia associated with recurrence...
  5. Kieval J, Karp C, Abou Shousha M, Galor A, Hoffman R, Dubovy S, et al. Ultra-high resolution optical coherence tomography for differentiation of ocular surface squamous neoplasia and pterygia. Ophthalmology. 2012;119:481-6 pubmed publisher
    ..To assess the use of an ultra-high-resolution (UHR) optical coherence tomography (OCT) as an adjuvant diagnostic tool in distinguishing ocular surface squamous neoplasia (OSSN) and pterygia...
  6. Vosganian G, Boisot S, Hartmann K, Freeman W, Sharpe R, Tripuraneni P, et al. Primary intraocular lymphoma: a review. J Neurooncol. 2011;105:127-34 pubmed publisher
    ..She enjoyed a 16-month remission but ultimately recurred in the brain. We reviewed the literature and present a discussion of the diagnostic criteria for PIOL and current strategies for treating PIOL in immunocompetent patients...
  7. Shousha M, Karp C, Perez V, Hoffmann R, Ventura R, Chang V, et al. Diagnosis and management of conjunctival and corneal intraepithelial neoplasia using ultra high-resolution optical coherence tomography. Ophthalmology. 2011;118:1531-7 pubmed publisher
    ..To report a novel diagnostic technique and a case series of conjunctival and corneal intraepithelial neoplasia (CCIN) diagnosed and followed up using prototype ultra high-resolution (UHR) optical coherence tomography (OCT)...
  8. Bianciotto C, Shields C, Guzman J, Romanelli Gobbi M, Mazzuca D, Green W, et al. Assessment of anterior segment tumors with ultrasound biomicroscopy versus anterior segment optical coherence tomography in 200 cases. Ophthalmology. 2011;118:1297-302 pubmed publisher
    ..To compare ultrasound biomicroscopy (UBM) versus anterior segment optical coherence tomography (AS-OCT) for imaging of tumors of the anterior segment of the eye...
  9. Lee S, Paik J, Cho W, Choi B, Lee S, Jung S, et al. Feasibility of the TNM-based staging system of ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Am J Hematol. 2011;86:262-6 pubmed publisher
    ..Thus, further studies to develop treatment strategies for reducing relapse after treatment for OAML should use the TNM staging system...

More Information

Publications62

  1. Mahajan A, Crum A, Johnson M, Materin M. Ocular neoplastic disease. Semin Ultrasound CT MR. 2011;32:28-37 pubmed publisher
  2. Frau E, Magnon C, Opolon P, Connault E, Opolon D, Beermann F, et al. A gene transfer comparative study of HSA-conjugated antiangiogenic factors in a transgenic mouse model of metastatic ocular cancer. Cancer Gene Ther. 2007;14:251-61 pubmed
    ..Our study indicates that systemic antiangiogenic factors production by recombinant adenoviruses, particularly Can, might represent an effective way of delaying metastatic growth via inhibition of angiogenesis...
  3. Chalasani R, Giblin M, Conway R. Role of topical chemotherapy for primary acquired melanosis and malignant melanoma of the conjunctiva and cornea: review of the evidence and recommendations for treatment. Clin Exp Ophthalmol. 2006;34:708-14 pubmed
    ..Topical MMC was well tolerated and shows considerable promise, particularly in the treatment of diffuse PAM with atypia. However, long-term data are lacking and further studies are required...
  4. Bischof M, Karagiozidis M, Krempien R, Treiber M, Neuhof D, Debus J, et al. Radiotherapy for orbital lymphoma : outcome and late effects. Strahlenther Onkol. 2007;183:17-22 pubmed
    ..To analyze the effectiveness of radiotherapy in the management of orbital non-Hodgkin's lymphoma (NHL)...
  5. Chinogurei T, Masanganise R, Rusakaniko S, Sibanda E. Ocular surface squamous neoplasia (OSSN) and human immunodeficiency virus at Sekuru Kaguvi Eye Unit in Zimbabwe: the role of operational research studies in a resource poor environment?. Cent Afr J Med. 2006;52:56-8 pubmed
    ..To determine the extent of association and relative risk of developing ocular surface squamous neoplasia (OSSN) among HIV positive patients seen in July 2004 at Sekuru Kaguvi Eye Unit, in Harare, Zimbabwe...
  6. Khong J, Muecke J. Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol. 2006;90:819-22 pubmed
    ..To determine the complications associated with mitomycin C (MMC) in the treatment of ocular surface neoplasia...
  7. Coupland S, Damato B. Understanding intraocular lymphomas. Clin Exp Ophthalmol. 2008;36:564-78 pubmed publisher
    ..It would be preferable to refer to the various forms of intraocular lymphoma according to whether they are retinal, choroidal, ciliary or iridal and whether they are primary or secondary in these locations...
  8. Davis J, Miller D, Ruiz P. Diagnostic testing of vitrectomy specimens. Am J Ophthalmol. 2005;140:822-829 pubmed
    ..To assess the usefulness of diagnostic tests that are performed on vitrectomy specimens from patients with suspected lymphoma or infection...
  9. Rosado M, Byrne G, Ding F, Fields K, Ruiz P, Dubovy S, et al. Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci. Blood. 2006;107:467-72 pubmed
    ..In South Florida, OALs are not associated with C psittaci infections...
  10. Manderwad G, Kannabiran C, Honavar S, Vemuganti G. Lack of association of high-risk human papillomavirus in ocular surface squamous neoplasia in India. Arch Pathol Lab Med. 2009;133:1246-50 pubmed publisher
    ..The genesis of OSSN is multifactorial, possibly including human papillomavirus (HPV) infection, the role of which is controversial...
  11. Frenkel S, Hendler K, Siegal T, Shalom E, Pe er J. Intravitreal methotrexate for treating vitreoretinal lymphoma: 10 years of experience. Br J Ophthalmol. 2008;92:383-8 pubmed publisher
    ..To describe our experience in treating vitreoretinal involvement of primary central nervous system lymphoma, by intravitreal injections of methotrexate (MTX)...
  12. Touitou V, Daussy C, Bodaghi B, Camelo S, de Kozak Y, Lehoang P, et al. Impaired th1/tc1 cytokine production of tumor-infiltrating lymphocytes in a model of primary intraocular B-cell lymphoma. Invest Ophthalmol Vis Sci. 2007;48:3223-9 pubmed
    ..To study the immune microenvironment in intraocular lymphomas and to characterize the cytokine polarization of infiltrating T-lymphocytes, a new murine model of intraocular B-cell lymphoma was developed...
  13. Zhang G, Winter J, Variakojis D, Reich S, Lissner G, Bryar P, et al. Lack of an association between Chlamydia psittaci and ocular adnexal lymphoma. Leuk Lymphoma. 2007;48:577-83 pubmed
    ..psittaci infection in various geographic regions or technical differences in the application of the assays may underlie the variability in the association between C. psittaci and ocular adnexal lymphoma...
  14. Waddell K, Kwehangana J, Johnston W, Lucas S, Newton R. A case-control study of ocular surface squamous neoplasia (OSSN) in Uganda. Int J Cancer. 2010;127:427-32 pubmed publisher
    ..We did not identify any additional factors that point to an underlying infectious cause, although this is an area of on-going research...
  15. Lee J, Kim M, Lee K, Hyun M, Chung H, Kim D, et al. Extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue-type of the orbit and ocular adnexa. Ann Hematol. 2005;84:13-8 pubmed
    ..Radiotherapy alone can produce excellent local control and survival in patients with localized MALT lymphoma of OOA. Systemic chemotherapy should be considered in patients with advanced stages or systemic manifestation...
  16. Radosevich M, Song Z, Gorga J, Ksander B, Ono S. Epigenetic silencing of the CIITA gene and posttranscriptional regulation of class II MHC genes in ocular melanoma cells. Invest Ophthalmol Vis Sci. 2004;45:3185-95 pubmed
    ..However, the mechanism(s) of this suppression is unknown. In this study, we have probed the molecular basis of this phenotype and report two distinct mechanisms underlying this phenotype...
  17. Gleizal A, Kodjikian L, Lebreton F, Beziat J. Early CT-scan for chronic lacrimal duct symptoms - case report of a malignant melanoma of the lacrimal sac and review of the literature. J Craniomaxillofac Surg. 2005;33:201-4 pubmed
    ..Any persistently symptomatic lacrimal duct system may need a maxillofacial consultation...
  18. Baehring J, Androudi S, Longtine J, Betensky R, Sklar J, Foster C, et al. Analysis of clonal immunoglobulin heavy chain rearrangements in ocular lymphoma. Cancer. 2005;104:591-7 pubmed
    ..The analysis of immunoglobulin heavy chain (IgH) gene rearrangements (AIGHR) was used as an adjunct to cytopathology and flow cytometry in systemic lymphoma. In IOL, the sensitivity and specificity of AIGHR are unknown...
  19. Yeh S, Weichel E, Faia L, Albini T, Wroblewski K, Stetler Stevenson M, et al. 25-Gauge transconjunctival sutureless vitrectomy for the diagnosis of intraocular lymphoma. Br J Ophthalmol. 2010;94:633-8 pubmed publisher
    ..The availability of expert ophthalmic pathological consultation, flow cytometry, cytokine evaluation and gene rearrangement studies were essential to the diagnosis...
  20. Rosenberg C, Finger P. Cutaneous malignant melanoma metastatic to the eye, lids, and orbit. Surv Ophthalmol. 2008;53:187-202 pubmed publisher
    ..Therefore, patients with ocular metastasis should be managed to prevent loss of vision or loss of the eye, and to maximize their quality of life...
  21. Wallace D, Shen D, Reed G, Miyanaga M, Mochizuki M, Sen H, et al. Detection of the bcl-2 t(14;18) translocation and proto-oncogene expression in primary intraocular lymphoma. Invest Ophthalmol Vis Sci. 2006;47:2750-6 pubmed
    ..This study examined the expression of the bcl-2 t(14;18) translocation, the bcl-10 gene, and high expression of bcl-6 mRNA in PIOL cells...
  22. Ponzoni M, Ferreri A, Guidoboni M, Lettini A, Cangi M, Pasini E, et al. Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methods. Clin Cancer Res. 2008;14:5794-800 pubmed publisher
    ..Herein, we used multiple Chlamydia detection tools to identify Cp elementary bodies-containing cell and to assess Cp prevalence in both nodal and extranodal lymphomas...
  23. Shields J, Demirci H, Marr B, Eagle R, Shields C. Sebaceous carcinoma of the ocular region: a review. Surv Ophthalmol. 2005;50:103-22 pubmed
  24. Pang C, Brown J, Ganote C, Youngberg G. A mass of the right lacrimal sac in a 53-year-old man. Arch Pathol Lab Med. 2005;129:1493-4 pubmed
  25. Nagaiah G, Stotler C, Orem J, Mwanda W, Remick S. Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa. Curr Opin Oncol. 2010;22:437-42 pubmed publisher
  26. Saxena S, Shanta A, Rajurkar N, Majali M. Studies on the production and quality assurance of miniature (125)I radioactive sources suitable for treatment of ocular and prostate cancers. Appl Radiat Isot. 2006;64:441-7 pubmed
    ..The surface contamination on the sealed capsules was found to be<0.05 nCi or 1.85 Bq per source. The sources were used in the treatment of a child having retinoblastoma...
  27. Chanudet E, Zhou Y, Bacon C, Wotherspoon A, Muller Hermelink H, Adam P, et al. Chlamydia psittaci is variably associated with ocular adnexal MALT lymphoma in different geographical regions. J Pathol. 2006;209:344-51 pubmed
    ..In conclusion, our results show that C. psittaci, but not C. pneumoniae, C. trachomatis, HSV1, HSV2, ADV8 or ADV19, is associated with ocular adnexal MALT lymphoma and that this association is variable in different geographical areas...
  28. Decaudin D, Dolcetti R, De Cremoux P, Ponzoni M, Vincent Salomon A, Doglioni C, et al. Variable association between Chlamydophila psittaci infection and ocular adnexal lymphomas: methodological biases or true geographical variations?. Anticancer Drugs. 2008;19:761-5 pubmed publisher
    ..psittaci antibodies. This paper also provides some methodological suggestions for future studies in the field of chlamydia-lymphoma associations...
  29. Moslehi R, Devesa S, Schairer C, Fraumeni J. Rapidly increasing incidence of ocular non-hodgkin lymphoma. J Natl Cancer Inst. 2006;98:936-9 pubmed
    ..By contrast, other NHLs showed evidence of peaking in recent years. The distinctive patterns of ocular NHL call for further studies to identify risk factors and mechanisms, including the potential role of C. psittaci or other infections...
  30. Kao S, Kau H, Tsai C, Tsay S, Yang C, Wu J, et al. Lacrimal gland extranodal marginal zone B-cell lymphoma of MALT-type. Am J Ophthalmol. 2007;143:311-316 pubmed
    ..To evaluate the clinical features and outcome of extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type (MALT lymphoma) in the lacrimal gland...
  31. Poothullil A, Colby K. Topical medical therapies for ocular surface tumors. Semin Ophthalmol. 2006;21:161-9 pubmed
    ..Topical agents were used as both primary and adjuvant therapy. Rates of tumor regression for CIN and squamous cell carcinoma ranged from 80 to 96%, and 70% of pigmented tumors regressed after an average follow-up of 27 months...
  32. Margo C. The Collaborative Ocular Melanoma Study: an overview. Cancer Control. 2004;11:304-9 pubmed
    ..The third arm is an observational study of small choroidal melanomas. Patient accrual ran from 1987 to 1998...
  33. Valenzuela A, Allen C, Grimes D, Wong D, Sullivan T. Positron emission tomography in the detection and staging of ocular adnexal lymphoproliferative disease. Ophthalmology. 2006;113:2331-7 pubmed
    ..To evaluate the role of fluorine 18 deoxyglucose positron emission tomography (FDG PET) in the initial staging of ocular adnexal lymphoma (OAL)...
  34. Kim C, Ha C, Lee S. Vitreous and retinal metastasis from gastric cancer. Eur J Ophthalmol. 2010;20:615-7 pubmed
    ..Intraocular metastasis from gastric cancer is not common and metastatic carcinoma to the vitreous or retina is exceedingly rare. We describe a case of gastric cancer metastatic to the vitreous and retina...
  35. Cassoux N, Giron A, Bodaghi B, Tran T, Baudet S, Davy F, et al. IL-10 measurement in aqueous humor for screening patients with suspicion of primary intraocular lymphoma. Invest Ophthalmol Vis Sci. 2007;48:3253-9 pubmed
    ..To determine the value of IL-10 measurement in aqueous humor (AH) for screening in primary intraocular lymphoma (PIOL)...
  36. Eide N, Walaas L. Fine-needle aspiration biopsy and other biopsies in suspected intraocular malignant disease: a review. Acta Ophthalmol. 2009;87:588-601 pubmed publisher
    ..Our view is controversial and contrary to opinion that supports current standards of care for this group of patients...
  37. Daibata M, Nemoto Y, Togitani K, Fukushima A, Ueno H, Ouchi K, et al. Absence of Chlamydia psittaci in ocular adnexal lymphoma from Japanese patients. Br J Haematol. 2006;132:651-2 pubmed
  38. Nam H, Ahn Y, Kim Y, Ko Y, Kim W. Prognostic significance of anatomic subsites: results of radiation therapy for 66 patients with localized orbital marginal zone B cell lymphoma. Radiother Oncol. 2009;90:236-41 pubmed publisher
    ..To evaluate the prognostic significance of anatomic subsites for marginal zone B cell lymphoma confined to the orbit...
  39. Coupland S, White V, Rootman J, Damato B, Finger P. A TNM-based clinical staging system of ocular adnexal lymphomas. Arch Pathol Lab Med. 2009;133:1262-7 pubmed publisher
    ..The Ann Arbor system has several shortcomings, particularly when staging extranodal non- Hodgkin lymphomas, such as OAL, which show different dissemination patterns from nodal lymphomas...
  40. McLaughlin C, Wu X, Jemal A, Martin H, Roche L, Chen V. Incidence of noncutaneous melanomas in the U.S. Cancer. 2005;103:1000-7 pubmed
    ..The current report was the largest in-depth descriptive analysis of incidence of noncutaneous melanoma in the United States, using data from the North American Association of Central Cancer Registries...
  41. Grover A, Alexander H. The past decade of experience with isolated hepatic perfusion. Oncologist. 2004;9:653-64 pubmed
    ..Patient selection is important to ensure good results with minimal morbidity and mortality. Work to define the appropriate clinical groups is ongoing at many clinical centers...
  42. Song E, Kim S, Kim T, Lee K, Yun T, Na I, et al. Efficacy of chemotherapy as a first-line treatment in ocular adnexal extranodal marginal zone B-cell lymphoma. Ann Oncol. 2008;19:242-6 pubmed
    ..This study was undertaken to analyze the efficacy of first-line chemotherapy in treating EMZBL. Chemotherapy was followed by radiotherapy only in recurrent cases...
  43. Nussenblatt R, Chan C, Wilson W, Hochman J, Gottesman M. International Central Nervous System and Ocular Lymphoma Workshop: recommendations for the future. Ocul Immunol Inflamm. 2006;14:139-44 pubmed
    ..To bring together multidisciplinary experts to discuss primary central nervous system lymphoma (PCNSL) and primary intraocular lymphoma (PIOL)...
  44. Ferry J, Fung C, Zukerberg L, Lucarelli M, Hasserjian R, Preffer F, et al. Lymphoma of the ocular adnexa: A study of 353 cases. Am J Surg Pathol. 2007;31:170-84 pubmed
    ..High-grade B-cell lymphomas only occasionally involve the ocular adnexa, and T-cell lymphoma, NK-cell lymphoma, and Hodgkin lymphoma are only rarely encountered in this site...
  45. Ferrufino Ponce Z, Henderson B. Radiotherapy and cataract formation. Semin Ophthalmol. 2006;21:171-80 pubmed
    ..Recently, additional studies have given insight into this important relationship and the efficacy of treatment options...
  46. Kaushik S, Gupta V, Singh R, Vasishta R, Rajwanshi A, Gupta A. Disseminated metastasis following periampullary cancer resection masquerading as uveitis. Indian J Ophthalmol. 2005;53:57-9 pubmed
    ..The Masquerade Syndrome was detected by cytological examination of the vitreous...
  47. Adam P, Haralambieva E, Hartmann M, Mao Z, Ott G, Rosenwald A. Rare occurrence of IgVH gene translocations and restricted IgVH gene repertoire in ocular MALT-type lymphoma. Haematologica. 2008;93:319-20 pubmed publisher
    ..Three out of 8 cases analyzed used the highly mutated VH3-23 gene and showed ongoing somatic hypermutations...
  48. Davis J. Diagnosis of intraocular lymphoma. Ocul Immunol Inflamm. 2004;12:7-16 pubmed
    ..To review current techniques for the diagnosis of intraocular lymphoma...
  49. Jakobiec F, Pineda R, Rivera R, Hsu Winges C, Cherwek D. Epicorneal polypoidal lipodermoid: lack of association of central corneal lesions with goldenhar syndrome verified with a review of the literature. Surv Ophthalmol. 2010;55:78-84 pubmed publisher
    ..Other epibulbar choristomas that can be confused with lipodermoids are described...
  50. Stefanovic A, Lossos I. Extranodal marginal zone lymphoma of the ocular adnexa. Blood. 2009;114:501-10 pubmed publisher
    ..In this review, we present a state-of-the-art summary of ocular adnexal MALT lymphomas...
  51. Decaudin D, Dendale R, Lumbroso Le Rouic L. Treatment of mucosa-associated lymphoid tissue-type ocular adnexal lymphoma. Anticancer Drugs. 2008;19:673-80 pubmed publisher
    ..The aims of this review are therefore to present the various treatment modalities and to discuss the place of each modality in the management of ophthalmologic lymphomas...
  52. Touitou V, Bodaghi B, de Kozak Y, Lehoang P, Sautes Fridman C, Fisson S. Animal models of intraocular lymphomas. Ophthalmic Res. 2008;40:208-11 pubmed publisher
  53. Margolis R, Brasil O, Lowder C, Singh R, Kaiser P, Smith S, et al. Vitrectomy for the diagnosis and management of uveitis of unknown cause. Ophthalmology. 2007;114:1893-7 pubmed
    ..To determine the diagnostic yield of tests commonly used for vitreous fluid analysis in eyes with suspected intraocular infection or malignancy...