thyroid neoplasms

Summary

Summary: Tumors or cancer of the THYROID GLAND.

Top Publications

  1. Segerhammar I, Larsson C, Nilsson I, Bäckdahl M, Höög A, Wallin G, et al. Anaplastic carcinoma of the thyroid gland: treatment and outcome over 13 years at one institution. J Surg Oncol. 2012;106:981-6 pubmed publisher
    ..Patients at our institution are treated with external radiotherapy up to 46 Gray (Gy) and low-dose doxorubicin prior to surgery. We retrospectively evaluated the outcome of ATC patients over a 13-year period...
  2. Hoofnagle A, Roth M. Clinical review: improving the measurement of serum thyroglobulin with mass spectrometry. J Clin Endocrinol Metab. 2013;98:1343-52 pubmed publisher
    ..As a result, many patients need additional imaging studies to rule out cancer persistence or recurrence that could be avoided with more sensitive and specific testing methods...
  3. Rossi E, Martini M, Capodimonti S, Straccia P, Cenci T, Lombardi C, et al. Diagnostic and prognostic value of immunocytochemistry and BRAF mutation analysis on liquid-based biopsies of thyroid neoplasms suspicious for carcinoma. Eur J Endocrinol. 2013;168:853-9 pubmed publisher
    ..The introduction of the liquid-based cytology (LBC) may simplify the application of these techniques to thyroid cytology...
  4. Verburg F, Mäder U, Tanase K, Thies E, Diessl S, Buck A, et al. Life expectancy is reduced in differentiated thyroid cancer patients ? 45 years old with extensive local tumor invasion, lateral lymph node, or distant metastases at diagnosis and normal in all other DTC patients. J Clin Endocrinol Metab. 2013;98:172-80 pubmed publisher
    ..The aim of this study was to determine how the all-cause mortality rate in DTC patients compares to that of the general population...
  5. Gupta N, Dasyam A, Carty S, Nikiforova M, Ohori N, Armstrong M, et al. RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers. J Clin Endocrinol Metab. 2013;98:E914-22 pubmed publisher
    ..RAS mutations are common in thyroid tumors and confer a high risk of cancer when detected in fine-needle aspiration (FNA) specimens. Specific characteristics of RAS-positive thyroid cancers are not well described...
  6. Liu X, Bishop J, Shan Y, Pai S, Liu D, Murugan A, et al. Highly prevalent TERT promoter mutations in aggressive thyroid cancers. Endocr Relat Cancer. 2013;20:603-10 pubmed publisher
  7. Lee S. Radioactive iodine therapy. Curr Opin Endocrinol Diabetes Obes. 2012;19:420-8 pubmed publisher
    ..Review of the management decisions that must be made by the endocrinologist during the use of radioactive iodine (RAI) therapy of hyperthyroidism and differentiated thyroid cancer...
  8. Bychkov A, Saenko V, Nakashima M, Mitsutake N, Rogounovitch T, Nikitski A, et al. Patterns of FOXE1 expression in papillary thyroid carcinoma by immunohistochemistry. Thyroid. 2013;23:817-28 pubmed publisher
    ..Its role in thyroid carcinogenesis, however, remains unknown. The purpose of the present study was to assess the relationship between the FOXE1 immunohistochemical features and the clinical and genetic characteristics of PTC...
  9. Rosario P, Dos Santos J, Calsolari M. Follow-up of patients with low-risk papillary thyroid carcinoma and undetectable basal serum thyroglobulin after ablation measured with a sensitive assay: a prospective study. Horm Metab Res. 2013;45:911-4 pubmed publisher
    ..After ablation, the risk of recurrence is very low in patients with low-risk PTC who show undetectable basal Tg measured with a sensitive assay, negative TgAb and negative US. ..

More Information

Publications62

  1. Giordano D, Valcavi R, Thompson G, Pedroni C, Renna L, Gradoni P, et al. Complications of central neck dissection in patients with papillary thyroid carcinoma: results of a study on 1087 patients and review of the literature. Thyroid. 2012;22:911-7 pubmed publisher
    ..Nevertheless, the morbidity that its routine use adds to the total thyroidectomy must be taken into account. The aim of this study was to characterize the morbidity that CND adds to the total thyroidectomy...
  2. Rosario P, Ward L, Carvalho G, Graf H, Maciel R, Maciel L, et al. Thyroid nodules and differentiated thyroid cancer: update on the Brazilian consensus. Arq Bras Endocrinol Metabol. 2013;57:240-64 pubmed
    ..The formulation of the present guidelines was based on the participants' experience and a review of the relevant literature. ..
  3. Caria P, Dettori T, Frau D, Di Oto E, Morandi L, Parmeggiani A, et al. Simultaneous occurrence of PAX8-PPARg and RET-PTC3 rearrangements in a follicular variant of papillary thyroid carcinoma. Am J Surg Pathol. 2012;36:1415-20 pubmed publisher
  4. Leonardi G, Candido S, Carbone M, Raiti F, Colaianni V, Garozzo S, et al. BRAF mutations in papillary thyroid carcinoma and emerging targeted therapies (review). Mol Med Rep. 2012;6:687-94 pubmed publisher
    ..The cinical implication of this molecular abnormality is also discussed. It is evident that the detection of the BRAF V600E mutation is crucial in order to identify novel avenues for thyroid cancer treatment...
  5. Zhou Y, Liu C, Dai X, Zhang X, Wang O. Overexpression of miR-221 is associated with aggressive clinicopathologic characteristics and the BRAF mutation in papillary thyroid carcinomas. Med Oncol. 2012;29:3360-6 pubmed publisher
    ..MiR-221 may be of potential importance in determining the aggressive properties of PTCs including the BRAF mutation, and it may further refine the risk stratification by BRAF mutation in PTCs...
  6. Zhao Z, Guo X, Ba C, Wang W, Yang Y, Wang J, et al. Overweight, obesity and thyroid cancer risk: a meta-analysis of cohort studies. J Int Med Res. 2012;40:2041-50 pubmed
    ..This meta-analysis examined the relationship between excess body weight or body mass index (BMI) and risk of thyroid cancer...
  7. Sohn Y, Yoon J, Moon H, Kim E, Kwak J. Mixed echoic thyroid nodules on ultrasound: approach to management. Yonsei Med J. 2012;53:812-9 pubmed publisher
    ..To evaluate malignancy risk according to ultrasound (US) features and size change on follow-up US in mixed echoic thyroid nodules and to suggest management guidelines thereof...
  8. Brose M, Nutting C, Jarzab B, Elisei R, Siena S, Bastholt L, et al. Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial. Lancet. 2014;384:319-28 pubmed publisher
    ..In this study, we assessed the efficacy and safety of orally administered sorafenib in the treatment of patients with this type of cancer...
  9. Lee S, Jung C, Kim T, Bae J, Jung S, Choi Y, et al. Molecular genotyping of follicular variant of papillary thyroid carcinoma correlates with diagnostic category of fine-needle aspiration cytology: values of RAS mutation testing. Thyroid. 2013;23:1416-22 pubmed publisher
    ..The follicular variant of papillary thyroid carcinoma (FVPTC) presents distinct histologic subtypes and molecular genotyping. The preoperative diagnosis of FVPTC through fine-needle aspiration cytology (FNAC) is challenging...
  10. Lim J, Hong S, Lee Y, Kim B, Park C, Chang H, et al. Clinicopathologic implications of the BRAF(V600E) mutation in papillary thyroid cancer: a subgroup analysis of 3130 cases in a single center. Thyroid. 2013;23:1423-30 pubmed publisher
    ..The objective of this study was to investigate the relationship of the BRAF mutation with clinicopathologic factors in a large group of homogenous PTC patients...
  11. Xing M. Molecular pathogenesis and mechanisms of thyroid cancer. Nat Rev Cancer. 2013;13:184-99 pubmed publisher
  12. Zimmermann A, Camenisch U, Rechsteiner M, Bode Lesniewska B, Rössle M. Value of immunohistochemistry in the detection of BRAF(V600E) mutations in fine-needle aspiration biopsies of papillary thyroid carcinoma. Cancer Cytopathol. 2014;122:48-58 pubmed publisher
    ..In thyroid neoplasms, mutation of the BRAF gene occurs rather exclusively in papillary thyroid carcinoma (PTC) and results in>..
  13. Nikiforova M, Wald A, Roy S, Durso M, Nikiforov Y. Targeted next-generation sequencing panel (ThyroSeq) for detection of mutations in thyroid cancer. J Clin Endocrinol Metab. 2013;98:E1852-60 pubmed publisher
    ..Next-generation sequencing (NGS) allows for high-throughput sequencing analysis of large regions of the human genome. We explored the use of targeted NGS for simultaneous testing for multiple mutations in thyroid cancer...
  14. Kitahara C, Linet M, Beane Freeman L, Check D, Church T, Park Y, et al. Cigarette smoking, alcohol intake, and thyroid cancer risk: a pooled analysis of five prospective studies in the United States. Cancer Causes Control. 2012;23:1615-24 pubmed publisher
    ..The results of this pooled analysis suggest that both cigarette smoking and alcohol consumption are associated with reduced risks of papillary thyroid cancer and, possibly, follicular thyroid cancer. ..
  15. Kuhn M, Bloom G, Myssiorek D. Patient perspectives on dysphonia after thyroidectomy for thyroid cancer. J Voice. 2013;27:111-4 pubmed publisher
    ..To determine the frequency and consequences of patient-reported post-thyroidectomy voice disorder (PTVD) after surgery for thyroid cancer...
  16. González Yebra B, Peralta R, González A, Ayala García M, de Zarate M, Salcedo M. Genetic alterations in a primary medullary thyroid carcinoma and its lymph node metastasis in a patient with 15 years follow-up. Diagn Pathol. 2012;7:63 pubmed publisher
    ..Specifically M918T RET mutation represents the main genetic event in most cases of sporadic MTC (SMTC) and limited chromosomal alterations analyses have been performed...
  17. Crane M, Strachan M, Toft A, Beckett G. Discordance in thyroglobulin measurements by radioimmunoassay and immunometric assay: a useful means of identifying thyroglobulin assay interference. Ann Clin Biochem. 2013;50:421-32 pubmed publisher
    ..We determined Tg assay discordance between a radioimmunoassay (RIA) and one of two immunometric assays (IMA) in DTC patients over a 9-year period to gauge assay performance against evidence of recurrent/progressive DTC...
  18. Marečko I, Cvejic D, Tatic S, Dragutinović V, Paunovic I, Savin S. Expression of matrix metalloproteinase-2 and its tissue inhibitor-2 in fetal and neoplastic thyroid tissue and their significance as diagnostic and prognostic markers in papillary carcinoma. Cancer Biomark. 2011;11:49-58 pubmed publisher
  19. de Matos L, Del Giglio A, Matsubayashi C, de Lima Farah M, del Giglio A, da Silva Pinhal M. Expression of CK-19, galectin-3 and HBME-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis. Diagn Pathol. 2012;7:97 pubmed publisher
    ..The aim of the present article was to establish the diagnostic accuracy of CK-19, Gal-3 and HBME-1 markers, as well as their associations, in the differentiation of malignant and benign thyroid lesions...
  20. Schneider T, Abdulrahman R, Corssmit E, Morreau H, Smit J, Kapiteijn E. Long-term analysis of the efficacy and tolerability of sorafenib in advanced radio-iodine refractory differentiated thyroid carcinoma: final results of a phase II trial. Eur J Endocrinol. 2012;167:643-50 pubmed publisher
    ..We conducted a prospective phase II clinical trial to determine the efficacy of sorafenib in patients with advanced radio-iodine refractory differentiated thyroid cancer. In this article, the long-term results are presented...
  21. Yu X, Jaskula Sztul R, Ahmed K, Harrison A, Kunnimalaiyaan M, Chen H. Resveratrol induces differentiation markers expression in anaplastic thyroid carcinoma via activation of Notch1 signaling and suppresses cell growth. Mol Cancer Ther. 2013;12:1276-87 pubmed publisher
  22. Giovanella L, Treglia G, Sadeghi R, Trimboli P, Ceriani L, Verburg F. Unstimulated highly sensitive thyroglobulin in follow-up of differentiated thyroid cancer patients: a meta-analysis. J Clin Endocrinol Metab. 2014;99:440-7 pubmed publisher
    ..Serum thyroglobulin (Tg) is an indicator of differentiated thyroid cancer (DTC) relapse...
  23. Santos L, Branco S, Silva S, Azevedo A, Gil O, Manita I, et al. Polymorphisms in base excision repair genes and thyroid cancer risk. Oncol Rep. 2012;28:1859-68 pubmed publisher
  24. Dralle H, Machens A. Surgical management of the lateral neck compartment for metastatic thyroid cancer. Curr Opin Oncol. 2013;25:20-6 pubmed publisher
    ..Lateral lymph node metastases are associated with locoregional recurrence and, when they involve either side of the neck, with mediastinal and distant metastases...
  25. Giovanella L, Imperiali M, Verburg F, Ceriani L. Evaluation of the BRAHMS Kryptor(®) thyroglobulin minirecovery test in patients with differentiated thyroid carcinoma. Clin Chem Lab Med. 2013;51:449-53 pubmed
    ..The present study was undertaken to evaluate a new sensitive thyroglobulin (Tg) mini-recovery test (Tg-mrec) for the detection of potential interferences in sera from patients with differentiated thyroid carcinoma (DTC) and low Tg levels...
  26. Mete O, Asa S. Pitfalls in the diagnosis of follicular epithelial proliferations of the thyroid. Adv Anat Pathol. 2012;19:363-73 pubmed publisher
    ..We believe that this review contains comprehensive and up to date information that will be of value to pathologists who practice surgical pathology of thyroid...
  27. Landa I, Ganly I, Chan T, Mitsutake N, Matsuse M, Ibrahimpasić T, et al. Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease. J Clin Endocrinol Metab. 2013;98:E1562-6 pubmed publisher
    ..Telomerase activity is required for cell immortalization. Somatic TERT promoter mutations modifying key transcriptional response elements were recently reported in several cancers, such as melanomas and gliomas...
  28. He H, Kashat L, Kak I, Kunavisarut T, Gundelach R, Kim D, et al. An Ep-ICD based index is a marker of aggressiveness and poor prognosis in thyroid carcinoma. PLoS ONE. 2012;7:e42893 pubmed publisher
    ..Here, we investigated the clinical significance of Ep-ICD subcellular localization index (ESLI) in distinguishing aggressive papillary thyroid carcinoma (PTC) from non-aggressive cases...
  29. Agate L, Lorusso L, Elisei R. New and old knowledge on differentiated thyroid cancer epidemiology and risk factors. J Endocrinol Invest. 2012;35:3-9 pubmed
    ..However, at present, the favorite hypothesis is that a complex interaction between genetic and environmental factors is required to develop DTC...
  30. Dralle H, Musholt T, Schabram J, Steinmuller T, Frilling A, Simon D, et al. German Association of Endocrine Surgeons practice guideline for the surgical management of malignant thyroid tumors. Langenbecks Arch Surg. 2013;398:347-75 pubmed publisher
    ..These developments called for an update of the previous practice guideline to detail the surgical treatment options that are available for the various disease entities and tumor stages...
  31. Jacques C, Guillotin D, Fontaine J, Franc B, Mirebeau Prunier D, Fleury A, et al. DNA microarray and miRNA analyses reinforce the classification of follicular thyroid tumors. J Clin Endocrinol Metab. 2013;98:E981-9 pubmed publisher
    ..Focusing on mitochondrial function and thyroid tumorigenesis, we used an integrative approach to identify relevant biomarkers for borderline thyroid lesions...
  32. Smallridge R, Ain K, Asa S, Bible K, Brierley J, Burman K, et al. American Thyroid Association guidelines for management of patients with anaplastic thyroid cancer. Thyroid. 2012;22:1104-39 pubmed publisher
    ..The development of these guidelines was supported by the American Thyroid Association (ATA), which requested the authors, members the ATA Taskforce for ATC, to independently develop guidelines for ATC...
  33. Jankovic B, Le K, Hershman J. Clinical Review: Hashimoto's thyroiditis and papillary thyroid carcinoma: is there a correlation?. J Clin Endocrinol Metab. 2013;98:474-82 pubmed publisher
    ..There are conflicting reports; some suggest that these two are positively correlated, whereas other studies report no relationship...
  34. Sancisi V, Borettini G, Maramotti S, Ragazzi M, Tamagnini I, Nicoli D, et al. Runx2 isoform I controls a panel of proinvasive genes driving aggressiveness of papillary thyroid carcinomas. J Clin Endocrinol Metab. 2012;97:E2006-15 pubmed publisher
    ..In a recent work, we reported that the transcriptional regulator Id1 contributes to thyroid cancer progression by powering the invasion capacity of tumor cells...
  35. Li N, Du X, Reitzel L, Xu L, Sturgis E. Impact of enhanced detection on the increase in thyroid cancer incidence in the United States: review of incidence trends by socioeconomic status within the surveillance, epidemiology, and end results registry, 1980-2008. Thyroid. 2013;23:103-10 pubmed publisher
    ..There has been debate on whether the increase is real or an artifact of improved diagnostic scrutiny. Our hypothesis is that both improved detection and a real increase have contributed to the increase...
  36. Verbeek H, Plukker J, Koopmans K, de Groot J, Hofstra R, Muller Kobold A, et al. Clinical relevance of 18F-FDG PET and 18F-DOPA PET in recurrent medullary thyroid carcinoma. J Nucl Med. 2012;53:1863-71 pubmed publisher
    ..We compared (18)F-FDG PET and (18)F-dihydroxyphenylanaline ((18)F-DOPA) PET with biochemical parameters and survival to assess whether these imaging modalities could be of value in detecting progressive disease...
  37. Baldini E, Sorrenti S, Catania A, Guaitoli E, Prinzi N, Mocini R, et al. Diagnostic utility of thyroglobulin measurement in the fine needle aspirates from cervical lymph nodes: a case report. G Chir. 2012;33:387-91 pubmed
    ..In conclusion, this case confirms that the cytological diagnosis of cystic lymph nodes is challenging, and that the measurement of Tg protein and/or mRNA in the needle washout may overcome this limitation...
  38. Barczynski M, Konturek A, Stopa M, Nowak W. Prophylactic central neck dissection for papillary thyroid cancer. Br J Surg. 2013;100:410-8 pubmed publisher
    ..Prophylactic central neck dissection (CND) for papillary thyroid cancer (PTC) remains controversial. The aim of this study was to examine whether prophylactic CND for PTC affected long-term survival and locoregional control...
  39. Nilubol N, Zhang L, Kebebew E. Multivariate analysis of the relationship between male sex, disease-specific survival, and features of tumor aggressiveness in thyroid cancer of follicular cell origin. Thyroid. 2013;23:695-702 pubmed publisher
    ..Thus, using a large population-based database, we sought to better characterize the role of sex in disease aggressiveness and outcome...
  40. Lee J, Kim Y, Choi J, Kim Y. The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis. Eur J Endocrinol. 2013;168:343-9 pubmed publisher
    ..No consensus exists on the association between papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT). To resolve this controversy, this study aimed to evaluate the relationship between the two conditions using a meta-analysis...
  41. Busco S, Giorgi Rossi P, Sperduti I, Pezzotti P, Buzzoni C, Pannozzo F. Increased incidence of thyroid cancer in Latina, Italy: a possible role of detection of subclinical disease. Cancer Epidemiol. 2013;37:262-9 pubmed publisher
    ..To describe the thyroid cancer incidence trends and geographical patterns in the Latina Province of Lazio, Italy using the population-based cancer registry...
  42. Chindris A, Diehl N, Crook J, Fatourechi V, Smallridge R. Undetectable sensitive serum thyroglobulin (<0.1 ng/ml) in 163 patients with follicular cell-derived thyroid cancer: results of rhTSH stimulation and neck ultrasonography and long-term biochemical and clinical follow-up. J Clin Endocrinol Metab. 2012;97:2714-23 pubmed publisher
    ..Surveillance of patients with differentiated thyroid cancer (DTC) is achieved using serum thyroglobulin (Tg), neck ultrasonography (US), and recombinant human TSH (rhTSH)-stimulated Tg (Tg-stim)...
  43. Roerink S, de Ridder M, Prins J, Huijbers A, de Wilt H, Marres H, et al. High level of distress in long-term survivors of thyroid carcinoma: results of rapid screening using the distress thermometer. Acta Oncol. 2013;52:128-37 pubmed publisher
    ..Cancer patients are at increased risk for distress. The Distress Thermometer (DT) and problem list (PL) are short-tools validated and recommended for distress screening in cancer patients...
  44. Giovanella L, Trimboli P, Verburg F, Treglia G, Piccardo A, Foppiani L, et al. Thyroglobulin levels and thyroglobulin doubling time independently predict a positive 18F-FDG PET/CT scan in patients with biochemical recurrence of differentiated thyroid carcinoma. Eur J Nucl Med Mol Imaging. 2013;40:874-80 pubmed publisher
    ..To assess the relationship between serum thyroglobulin (Tg) levels, Tg doubling time (Tg-DT) and the diagnostic performance of (18)F-FDG PET/CT in detecting recurrences of (131)I-negative differentiated thyroid carcinoma (DTC)...
  45. Valle L, Gorodeski Baskin R, Porter K, SIPOS J, Khawaja R, Ringel M, et al. In thyroidectomized patients with thyroid cancer, a serum thyrotropin of 30??U/mL after thyroxine withdrawal is not always adequate for detecting an elevated stimulated serum thyroglobulin. Thyroid. 2013;23:185-93 pubmed publisher
  46. Wang Y, Li L, Wang Y, Feng X, Zhao F, Zou S, et al. Ultrasound findings of papillary thyroid microcarcinoma: a review of 113 consecutive cases with histopathologic correlation. Ultrasound Med Biol. 2012;38:1681-8 pubmed publisher
    ..Psammoma bodies detected at a frequency ?5 per ×200 microscopic field of view were detectable on US as microcalcifications...
  47. Ito Y, Nikiforov Y, Schlumberger M, Vigneri R. Increasing incidence of thyroid cancer: controversies explored. Nat Rev Endocrinol. 2013;9:178-84 pubmed publisher
    ..In this article, Nature Reviews Endocrinology asks four experts their opinions on some of the controversies surrounding the changing trends in thyroid cancer incidence...
  48. Treglia G, Cocciolillo F, Di Nardo F, Poscia A, de Waure C, Giordano A, et al. Detection rate of recurrent medullary thyroid carcinoma using fluorine-18 dihydroxyphenylalanine positron emission tomography: a meta-analysis. Acad Radiol. 2012;19:1290-9 pubmed publisher
  49. Nascimento C, Borget I, Troalen F, Al Ghuzlan A, Deandreis D, Hartl D, et al. Ultrasensitive serum thyroglobulin measurement is useful for the follow-up of patients treated with total thyroidectomy without radioactive iodine ablation. Eur J Endocrinol. 2013;169:689-93 pubmed publisher
  50. McNally R, Blakey K, James P, Gomez Pozo B, Basta N, Hale J. Increasing incidence of thyroid cancer in Great Britain, 1976-2005: age-period-cohort analysis. Eur J Epidemiol. 2012;27:615-22 pubmed publisher
    ..The reasons for this increase are not well understood, but it is consistent with findings from other countries...
  51. Durante C, Montesano T, Attard M, Torlontano M, Monzani F, Costante G, et al. Long-term surveillance of papillary thyroid cancer patients who do not undergo postoperative radioiodine remnant ablation: is there a role for serum thyroglobulin measurement?. J Clin Endocrinol Metab. 2012;97:2748-53 pubmed
    ..However, the postsurgical profile of Tg levels has never been specifically investigated in patients who do not undergo radioiodine remnant ablation (RRA)...
  52. Niu D, Kondo T, Nakazawa T, Oishi N, Kawasaki T, Mochizuki K, et al. Transcription factor Runx2 is a regulator of epithelial-mesenchymal transition and invasion in thyroid carcinomas. Lab Invest. 2012;92:1181-90 pubmed publisher
    ..Our data suggest that enhanced Runx2 is functionally linked to tumor invasion and metastasis of thyroid carcinoma by regulating EMT-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors...
  53. Shih S, Chiu W, Chang T, Tseng C. Diabetes and thyroid cancer risk: literature review. Exp Diabetes Res. 2012;2012:578285 pubmed publisher