testicular neoplasms

Summary

Summary: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

Top Publications

  1. Chen Y, Cao D, Chiu R, Lee P. Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas. Cancer Immun. 2013;13:10 pubmed
  2. Dieckmann K, Wilken S, Loy V, Matthies C, Kleinschmidt K, Bedke J, et al. Treatment of testicular intraepithelial neoplasia (intratubular germ cell neoplasia unspecified) with local radiotherapy or with platinum-based chemotherapy: a survey of the German Testicular Cancer Study Group. Ann Oncol. 2013;24:1332-7 pubmed publisher
    ..The treatment of testicular intraepithelial neoplasia (TIN), the progenitor of testicular germ cell tumours (GCTs), is based on little data...
  3. Biswal B, Beyrouthy M, Hever Jardine M, Armstrong D, Tomlinson C, Christensen B, et al. Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS ONE. 2012;7:e53003 pubmed publisher
    ..Low-dose 5-aza therapy may be a general strategy to treat those tumors that are sustained by cells with embryonic stem-like properties.GEO NUMBER FOR THE MICROARRAY DATA: GSE42647...
  4. Sabbaghian N, Bahubeshi A, Shuen A, Kanetsky P, Tischkowitz M, Nathanson K, et al. Germ-line DICER1 mutations do not make a major contribution to the etiology of familial testicular germ cell tumours. BMC Res Notes. 2013;6:127 pubmed publisher
    ..To further explore the importance of DICER1 mutations in the etiology of testicular germ cell tumors (TGCT), we studied germ-line DNA samples from 43 probands diagnosed with familial TGCT...
  5. Beard C, Travis L, Chen M, Arvold N, Nguyen P, Martin N, et al. Outcomes in stage I testicular seminoma: a population-based study of 9193 patients. Cancer. 2013;119:2771-7 pubmed publisher
    ..In particular, data describing long-term risks of cardiovascular disease (CVD) are conflicting...
  6. Chung C, Kanetsky P, Wang Z, Hildebrandt M, Koster R, Skotheim R, et al. Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet. 2013;45:680-5 pubmed publisher
    ..These new TGCT susceptibility loci contain biologically plausible genes encoding proteins important for male germ cell development, chromosomal segregation and the DNA damage response. ..
  7. Rud C, Daugaard G, Rajpert De Meyts E, Skakkebæk N, Petersen J, Jørgensen N. Sperm concentration, testicular volume and age predict risk of carcinoma in situ in contralateral testis of men with testicular germ cell cancer. J Urol. 2013;190:2074-80 pubmed publisher
    ..We investigated whether semen quality or some easily attainable clinical parameters might be used to estimate the risk of contralateral carcinoma in situ in patients with unilateral testicular germ cell tumors...
  8. Kristensen D, Skakkebæk N, Rajpert De Meyts E, Almstrup K. Epigenetic features of testicular germ cell tumours in relation to epigenetic characteristics of foetal germ cells. Int J Dev Biol. 2013;57:309-17 pubmed publisher
  9. Ruark E, Seal S, McDonald H, Zhang F, Elliot A, Lau K, et al. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. Nat Genet. 2013;45:686-9 pubmed publisher
    ..3, is required for the regulation of germ cell development. Furthermore, PITX1, at 5q31.1, regulates TERT expression and is the third TGCT-associated locus implicated in telomerase regulation...

More Information

Publications61

  1. Bremmer F, Schweyer S, Behnes C, Blech M, Radzun H. Sertoliform cystadenoma: a rare benign tumour of the rete testis. Diagn Pathol. 2013;8:23 pubmed publisher
    ..Because of the benign nature of this tumour the correct diagnosis is important for the intra- and postoperative management. Here we present a case of this rare tumour and discuss potential differential diagnosis...
  2. Juliachs M, Castillo Avila W, Vidal A, Piulats J, Garcia del Muro X, Condom E, et al. ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor. Int J Cancer. 2013;133:235-46 pubmed publisher
    ..Our results explain why lapatinib but not anti-ErbB1 agents might be effective for treatment of testicular GCT patients...
  3. Tsili A, Argyropoulou M, Giannakis D, Sofikitis N, Tsampoulas K. MRI in the characterization and local staging of testicular neoplasms. AJR Am J Roentgenol. 2010;194:682-9 pubmed publisher
    The purpose of this study was to assess the role of MRI in the preoperative characterization and local staging of testicular neoplasms.
  4. Gilbert D, Rapley E, Shipley J. Testicular germ cell tumours: predisposition genes and the male germ cell niche. Nat Rev Cancer. 2011;11:278-88 pubmed publisher
    ..Furthermore, this improved understanding of the mechanisms underlying TGCT development and dissemination has clinical relevance for the management of patients with these tumours...
  5. Dohle G, Elzanaty S, van Casteren N. Testicular biopsy: clinical practice and interpretation. Asian J Androl. 2012;14:88-93 pubmed publisher
    ..In this mini-review, we describe the current indications for testicular biopsies in the diagnosis and management of male infertility...
  6. Masterson T, Carver B, Shayegan B, Feldman D, Motzer R, Bosl G, et al. Outcomes in patients with clinical stage III NSGCT who achieve complete clinical response to chemotherapy at extraretroperitoneal disease site. Urology. 2012;79:1079-84 pubmed publisher
    ..To compare the survival outcomes of patients with advanced nonseminoma and extraretroperitoneal (ERP) disease observed for a clinical complete response (CCR) with those demonstrating a pathologic complete response (PCR)...
  7. Hersmus R, Stoop H, van de Geijn G, Eini R, Biermann K, Oosterhuis J, et al. Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas. PLoS ONE. 2012;7:e43952 pubmed publisher
    ..This data supports the existence of two distinct but parallel pathways in the development of dysgerminoma, in which mutational status of c-KIT might parallel the presence of TSPY...
  8. Schaapveld M, van den Belt Dusebout A, Gietema J, de Wit R, Horenblas S, Witjes J, et al. Risk and prognostic significance of metachronous contralateral testicular germ cell tumours. Br J Cancer. 2012;107:1637-43 pubmed publisher
    ..Testicular germ cell tumour (TGCT) patients are at increased risk of developing a contralateral testicular germ cell tumour (CTGCT). It is unclear whether TGCT treatment affects CTGCT risk...
  9. Ahmed H, Arya M, Muneer A, Mushtaq I, Sebire N. Testicular and paratesticular tumours in the prepubertal population. Lancet Oncol. 2010;11:476-83 pubmed publisher
    ..We provide an up-to-date and comprehensive review of the clinical presentation, imaging, pathology, and clinical management of prepubertal paratesticular and testicular tumours...
  10. Batista Arteaga M, Suárez Bonnet A, Santana M, Nino T, Reyes R, Alamo D. Testicular neoplasms (interstitial and Sertoli cell tumours) in a domestic ferret (Mustela putorius furo). Reprod Domest Anim. 2011;46:177-80 pubmed publisher
    ..Clinical evaluation of the ferret did not show any other apparent pathological processes. This study is the first case reporting the concomitant occurrence of a Sertoli cells tumour and an interstitial cell tumour in a domestic ferret...
  11. Nuver J, de Haas E, van Zweeden M, Gietema J, Meijer C. Vascular damage in testicular cancer patients: a study on endothelial activation by bleomycin and cisplatin in vitro. Oncol Rep. 2010;23:247-53 pubmed
    ..Strategies aimed at these functions should be developed in order to ameliorate or prevent cytostatic agent-induced vascular damage...
  12. Aggarwal P, Sidana A, Mustafa S, Rodriguez R. Preoperative diagnosis of malignant mesothelioma of the tunica vaginalis using Doppler ultrasound. Urology. 2010;75:251-2 pubmed publisher
    ..He underwent early radical orchiectomy through an inguinal approach, resulting in improved survival...
  13. Brydøy M, Fossa S, Klepp O, Bremnes R, Wist E, Wentzel Larsen T, et al. Paternity and testicular function among testicular cancer survivors treated with two to four cycles of cisplatin-based chemotherapy. Eur Urol. 2010;58:134-40 pubmed publisher
    ..Preserved fertility is an important issue for testicular cancer (TC) survivors...
  14. Schmoll H, Osanto S, Kawai K, Einhorn L, Fizazi K. Advanced seminoma and nonseminoma: SIU/ICUD Consensus Meeting on Germ Cell Tumors (GCT), Shanghai 2009. Urology. 2011;78:S456-68 pubmed publisher
    ..Draft guidelines were presented at an International Consensus in Urological Disease (ICUD) meeting (Shanghai, November 2009). The writing committee compiled the results of the discussion. All participants agreed to this final update...
  15. Giannandrea F, Gandini L, Paoli D, Turci R, Figà Talamanca I. Pesticide exposure and serum organochlorine residuals among testicular cancer patients and healthy controls. J Environ Sci Health B. 2011;46:780-7 pubmed publisher
    ..34, 95 % CI: 1.09-10.17) in cases compared with controls. These findings give additional support to the results of previous research that suggest that some environmental exposures to OPs may be implicated in the pathogenesis of TC...
  16. Bush J, Gardiner D, Palmer J, Rajpert De Meyts E, Veeramachaneni D. Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours. Int J Androl. 2011;34:e288-95; discussion e295 pubmed publisher
    ..Canine spermatocytic seminomas may provide a useful model for this rare human neoplasm...
  17. Looijenga L. Spermatocytic seminoma: toward further understanding of pathogenesis. J Pathol. 2011;224:431-3 pubmed publisher
    ..However, this does not exclude an earlier cell of origin, possibly explaining the unique properties of this type of human germ cell tumour, with various counterparts in animals...
  18. Frost G, Brown T, Harding A. Mortality and cancer incidence among British agricultural pesticide users. Occup Med (Lond). 2011;61:303-10 pubmed publisher
    ..Although the acute effects of pesticides in humans are well known, uncertainty still exists about the health effects of chronic low-level exposure to pesticides...
  19. Köberle B, Brenner W, Albers A, Usanova S, ThUroff J, Kaina B. ERCC1 and XPF expression in human testicular germ cell tumors. Oncol Rep. 2010;23:223-7 pubmed
    ..The data indicate a possible up-regulation of ERCC1 and XPF during TGCT progression...
  20. Vesprini D, Chung P, Tolan S, Gospodarowicz M, Jewett M, O Malley M, et al. Utility of serum tumor markers during surveillance for stage I seminoma. Cancer. 2012;118:5245-50 pubmed publisher
    ..In this study, the authors evaluated the utility of routine measurement of these markers in the detection of disease relapse...
  21. Zequi S, da Costa W, Santana T, Favaretto R, Sacomani C, Guimaraes G. Bilateral testicular germ cell tumours: a systematic review. BJU Int. 2012;110:1102-9 pubmed publisher
    ..Thus, an extensive review containing 94 studies and more than 50,000 patients was conducted...
  22. Maruta S, Shida Y, Takehara K, Onita T, Igawa T, Sakai H. [A case report of bilateral spermatocytic seminoma]. Hinyokika Kiyo. 2011;57:525-8 pubmed
    ..Histological diagnosis was bilateral spermatocytic seminoma, pT1. After the operation, this patient was followed closely without adjuvant therapy. There has been no sign of recurrence at five months after the operation...
  23. Trpkov K, Barr R, Kulaga A, Yilmaz A. Mesothelioma of tunica vaginalis of "uncertain malignant potential" - an evolving concept: case report and review of the literature. Diagn Pathol. 2011;6:78 pubmed publisher
    ..Documentation of these rare tumors will allow their distinction from true malignant mesotheliomas and will facilitate the development of specific treatment recommendations...
  24. Dieckmann K, Kulejewski M, Heinemann V, Loy V. Testicular biopsy for early cancer detection--objectives, technique and controversies. Int J Androl. 2011;34:e7-13 pubmed publisher
    ..Further candidates for biopsy are selected patients with sonographic testicular microlithiasis. Despite its usefulness, the procedure has been implemented in clinical routine only in few countries thus far...
  25. Zhu R, HEANEY J, Nadeau J, Ali S, Matin A. Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res. 2010;70:7264-72 pubmed publisher
    ..Our data indicate that Sf1 levels in mouse strains correlate with their incidences of TGCTs and implicate the importance of splicing mechanisms in germ cell tumorigenesis...
  26. Almstrup K, Nielsen J, Mlynarska O, Jansen M, Jørgensen A, Skakkebæk N, et al. Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells. Br J Cancer. 2010;103:1269-76 pubmed publisher
    ..The CIS cell is a neoplastic counterpart of foetal germ cells. During their development, foetal germ cells undergo extensive and essential epigenetic modifications, but little is known about epigenetic patterns in CIS cells...
  27. Kratz C, Mai P, Greene M. Familial testicular germ cell tumours. Best Pract Res Clin Endocrinol Metab. 2010;24:503-13 pubmed publisher
    ..Notably, all five loci are involved in the biology of primordial germ cells, representing the cell of origin of TGCT, suggesting that the tumours arise as a result of disturbed testicular development...
  28. Sijmons R, Vos Y, Herkert J, Bos K, Lutke Holzik M, Hoekstra Weebers J, et al. Screening for germline DND1 mutations in testicular cancer patients. Fam Cancer. 2010;9:439-42 pubmed publisher
    ..The role of human DND1 in normal physiology and disease, however, is still virtually unknown and it therefore warrants further research...
  29. Palmer R, Murray M, Saini H, van Dongen S, Abreu Goodger C, Muralidhar B, et al. Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. Cancer Res. 2010;70:2911-23 pubmed publisher
    ..05). We conclude that the miR-371-373 and miR-302 clusters are universally overexpressed in malignant GCTs and coordinately downregulate mRNAs involved in biologically significant pathways...
  30. Purdue M, Engel L, Langseth H, Needham L, Andersen A, Barr D, et al. Prediagnostic serum concentrations of organochlorine compounds and risk of testicular germ cell tumors. Environ Health Perspect. 2009;117:1514-9 pubmed publisher
    ..Recent findings suggest that exposure to organochlorine (OC) compounds, chlordanes and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in particular, may increase the risk of developing testicular germ cell tumors (TGCTs)...
  31. Horn T, Schulz S, Maurer T, Gschwend J, Kübler H. Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma. Med Oncol. 2011;28 Suppl 1:S423-5 pubmed publisher
    ..A review of the literature showed that all the three described patients developing metastatic disease did not receive adjuvant radiation therapy after orchiectomy, which might be considered in high-risk cases...
  32. Neumann J, Chandler G, Damoulis V, Fustino N, Lillard K, Looijenga L, et al. Mutation in the type IB bone morphogenetic protein receptor Alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proc Natl Acad Sci U S A. 2011;108:13153-8 pubmed publisher
    ..These results indicate a germ-cell-autonomous role for BMP signal transduction in germ-cell differentiation, and highlight the importance of the BMP pathway in human GCTs...
  33. Matos E, Skrbinc B, Zakotnik B. Fertility in patients treated for testicular cancer. J Cancer Surviv. 2010;4:274-8 pubmed publisher
    ..To further elucidate the question of fertility after treatment for testicular cancer, we performed a survey in patients treated in our institution...
  34. Xiao G, Mccash S, Unger P. Paraganglia mimicking metastatic seminomatous tumor. Int J Surg Pathol. 2011;19:534-7 pubmed publisher
    ..Awareness of the presence of paraganglia and their distinction from metastatic disease is of practical importance in avoiding an overdiagnosis of malignancy and assuring proper patient management...
  35. McGlynn K, Trabert B. Adolescent and adult risk factors for testicular cancer. Nat Rev Urol. 2012;9:339-49 pubmed publisher
  36. Lombardi M, Valli M, Brisigotti M, Rosai J. Spermatocytic seminoma: review of the literature and description of a new case of the anaplastic variant. Int J Surg Pathol. 2011;19:5-10 pubmed publisher
    ..Surprisingly, the presence of an anaplastic component does not seem to impact on this excellent prognosis. Very different is the case of sarcomatous transformation, for which further therapy after orchiectomy is advisable...
  37. Winter C, Albers P. Testicular germ cell tumors: pathogenesis, diagnosis and treatment. Nat Rev Endocrinol. 2011;7:43-53 pubmed publisher
    ..High-dose chemotherapy represents a curative option for patients with second or subsequent relapses...
  38. Novotny G, Belling K, Bramsen J, Nielsen J, Bork Jensen J, Almstrup K, et al. MicroRNA expression profiling of carcinoma in situ cells of the testis. Endocr Relat Cancer. 2012;19:365-79 pubmed publisher
    ..We conclude that the miRNA expression profile changes during testis development and that the miRNA profile of adult testis with CIS cells shares characteristic similarities with the expression in foetal gonocytes...
  39. Hes O, Vanecek T, Petersson F, Grossmann P, Hora M, Perez Montiel D, et al. Mutational analysis (c.402C>G) of the FOXL2 gene and immunohistochemical expression of the FOXL2 protein in testicular adult type granulosa cell tumors and incompletely differentiated sex cord stromal tumors. Appl Immunohistochem Mol Morphol. 2011;19:347-51 pubmed publisher
    ..Whether this mutation is present in testicular ATGCT or incompletely differentiated sex cord stromal tumor (ISCST) is not known...
  40. Koster R, Timmer Bosscha H, Bischoff R, Gietema J, de Jong S. Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway. Cell Death Dis. 2011;2:e148 pubmed publisher
    ..Finally, we demonstrate that Nutlin-3 strongly augmented cisplatin-induced apoptosis and cell kill via the Fas death receptor pathway. This effect is most pronounced in cisplatin-resistant TC cells...
  41. Chen Y, Chiu R, Lee P, Beneck D, Jin B, Old L. Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma. Hum Reprod. 2011;26:3232-43 pubmed publisher
    ..Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined...
  42. Gutekunst M, Oren M, Weilbacher A, Dengler M, Markwardt C, Thomale J, et al. p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin. PLoS ONE. 2011;6:e19198 pubmed publisher
    ..Furthermore, in the very specific cellular context of germ cell-derived pluripotent EC cells, p53 function appears to be limited to induction of apoptosis...
  43. Lim J, Goriely A, Turner G, Ewen K, Jacobsen G, Graem N, et al. OCT2, SSX and SAGE1 reveal the phenotypic heterogeneity of spermatocytic seminoma reflecting distinct subpopulations of spermatogonia. J Pathol. 2011;224:473-83 pubmed publisher
  44. Schnack T, Poulsen G, Myrup C, Wohlfahrt J, Melbye M. Familial coaggregation of cryptorchidism, hypospadias, and testicular germ cell cancer: a nationwide cohort study. J Natl Cancer Inst. 2010;102:187-92 pubmed publisher
    ..To address the inheritability of this syndrome, we examined whether family history of cryptorchidism or hypospadias is associated with an increased risk of TGCC...
  45. Beyrouthy M, Garner K, Hever M, Freemantle S, Eastman A, Dmitrovsky E, et al. High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors. Cancer Res. 2009;69:9360-6 pubmed publisher
    ..These novel findings indicate that high expression of DNMT3B, a likely byproduct of their pluripotency and germ cell origin, sensitizes TGCT-derived EC cells to low-dose 5-aza-CdR treatment...
  46. Sarfati D, Shaw C, Blakely T, Atkinson J, Stanley J. Ethnic and socioeconomic trends in testicular cancer incidence in New Zealand. Int J Cancer. 2011;128:1683-91 pubmed publisher
    ..Given the lack of understanding of the etiology of testicular cancer, the unusual patterns identified in the New Zealand context may provide some etiological clues for future novel research...
  47. Nitzsche B, Gloesenkamp C, Schrader M, Ocker M, Preissner R, Lein M, et al. Novel compounds with antiangiogenic and antiproliferative potency for growth control of testicular germ cell tumours. Br J Cancer. 2010;103:18-28 pubmed publisher
    ..g., VEGFR, PDGFR), we identified two compounds (HP-2 and HP-14) with antiangiogenic and antiproliferative potency, which were evaluated in endothelial cell models and TGCT cells...
  48. Kollmannsberger C, Tyldesley S, Moore C, Chi K, Murray N, Daneshmand S, et al. Evolution in management of testicular seminoma: population-based outcomes with selective utilization of active therapies. Ann Oncol. 2011;22:808-14 pubmed publisher
  49. Nelson V, Heaney J, Tesar P, Davidson N, Nadeau J. Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability. Proc Natl Acad Sci U S A. 2012;109:E2766-73 pubmed publisher
    ..These results suggest that Apobec1 plays a central role in controlling TGCT susceptibility in both a conventional and a transgenerational manner...
  50. Kristensen D, Mlynarska O, Nielsen J, Jacobsen G, Rajpert De Meyts E, Almstrup K. Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype. Cancer Genet. 2012;205:425-31 pubmed publisher
  51. Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ER?) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
    ..These data, supporting estrogen-dependency of human seminoma, propose ER? ligands for therapeutic use in the treatment of this pathological condition...
  52. Oechsle K, Kollmannsberger C, Honecker F, Mayer F, Waller C, Hartmann J, et al. Long-term survival after treatment with gemcitabine and oxaliplatin with and without paclitaxel plus secondary surgery in patients with cisplatin-refractory and/or multiply relapsed germ cell tumors. Eur Urol. 2011;60:850-5 pubmed publisher