paraneoplastic endocrine syndromes

Summary

Summary: Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion.

Top Publications

  1. DeLellis R, Xia L. Paraneoplastic endocrine syndromes: a review. Endocr Pathol. 2003;14:303-17 pubmed
    The paraneoplastic endocrine syndromes ("ectopic" or "inappropriate" hormone production) comprise a wide array of symptom complexes associated with malignant or less commonly benign neoplasms...
  2. Nasr C, Mason A, Mayberg M, Staugaitis S, Asa S. Acromegaly and somatotroph hyperplasia with adenomatous transformation due to pituitary metastasis of a growth hormone-releasing hormone-secreting pulmonary endocrine carcinoma. J Clin Endocrinol Metab. 2006;91:4776-80 pubmed
    ..GHRH excess from extracranial endocrine tumors is known to cause somatotroph hyperplasia and acromegaly. Hypothalamic gangliocytomas producing GHRH are also known to be associated with pituitary adenomas causing acromegaly...
  3. Athanassiadi K, Exarchos D, Tsagarakis S, Bellenis I. Acromegaly caused by ectopic growth hormone-releasing hormone secretion by a carcinoid bronchial tumor: a rare entity. J Thorac Cardiovasc Surg. 2004;128:631-2 pubmed
  4. Altstadt T, Azzarelli B, Bevering C, Edmondson J, Nelson P. Acromegaly caused by a growth hormone-releasing hormone-secreting carcinoid tumor: case report. Neurosurgery. 2002;50:1356-9; discussion 1360 pubmed
    ..This case report illustrates the importance of including this rare clinical syndrome in the differential diagnosis of acromegaly for patients with suspected or known neuroendocrine tumors...
  5. Frohman L, Kineman R. Growth hormone-releasing hormone and pituitary somatotrope proliferation. Minerva Endocrinol. 2002;27:277-85 pubmed
    ..However, many features of the cellular pathways remain to be defined, including the interaction of other genes in the multistep process of somatotrope tumorigenesis...
  6. Mnif H, Makni S, Gheriani M, Sellami A, Abid M, Sellami Boudawara T. [Pancreatic endocrine tumor secreting growth hormone]. Ann Pathol. 2005;25:412-4 pubmed
  7. Swain J, Pirie R, Hudson N, Else R, Evans H, McGorum B. Insulin-like growth factors and recurrent hypoglycemia associated with renal cell carcinoma in a horse. J Vet Intern Med. 2005;19:613-6 pubmed
  8. Oosting S, de Haas E, Links T, de Bruin D, Sluiter W, de Jong I, et al. Prevalence of paraneoplastic hyperthyroidism in patients with metastatic non-seminomatous germ-cell tumors. Ann Oncol. 2010;21:104-8 pubmed publisher
    ..Patients with elevated human chorionic gonadotrophin (HCG) can have hyperthyroidism. We assessed the prevalence of hyperthyroidism in patients presenting with disseminated non-seminomatous germ-cell tumors (NSGCT)...
  9. Nakanishi T. [Human chorionic gonadotropin in non-trophoblastic cancer]. Nihon Rinsho. 2006;Suppl 3:299-302 pubmed

More Information

Publications62

  1. Ishibashi M. [Ectopic hormone-producing tumor]. Nihon Rinsho. 2004;62:894-900 pubmed
  2. Rutherford G, Dineen R, O CONNOR A. Imaging in the investigation of paraneoplastic syndromes. Clin Radiol. 2007;62:1021-35 pubmed
    ..In this review the important paraneoplastic syndromes and underlying malignancies are discussed along with relevant imaging strategies...
  3. Joubert M, Reznik Y, Verdon R. "Rescue" bilateral adrenalectomy in paraneoplastic Cushing's syndrome with invasive Aspergillus fumigatus infection. Am J Med Sci. 2007;334:497-8 pubmed
    ..We emphasize surgical management of hypercortisolism to achieve rapid blunting of cortisol production in a such life-threatening situation...
  4. ZaƂuska M, Janota B, Papierska L. [Personality and behavioural disturbances, with delusional-hallucinatory and delirium episodes in the course of hyponatremia due to paraneoplastic inappropriate vasopressin secretion (SIADH)]. Psychiatr Pol. 2006;40:1149-60 pubmed
    ..To broaden the knowledge about somatic mechanisms of psychic disturbances...
  5. Mishra A, Agarwal G, Misra A, Agarwal A, Mishra S. Functioning adrenal tumours in children and adolescents: an institutional experience. ANZ J Surg. 2001;71:103-7 pubmed
    ..The purpose of the present paper was to carry out an audit of clinicopathological profile and treatment outcome in 13 children with functioning adrenal tumours...
  6. Ando T, Hosokawa A, Yamawaki H, Hasumoto Y, Kajiura S, Itaya Y, et al. Esophageal small-cell carcinoma with syndrome of inappropriate secretion of antidiuretic hormone. Intern Med. 2011;50:1099-103 pubmed
    ..This case demonstrates that esophageal SCC could induce SIADH as a paraneoplastic syndrome and that the above combined chemotherapy was feasible and effective...
  7. Duarte F, Jallad R, Salgado L, Bronstein M. [TSH-secreting pituitary tumors: two case reports and literature review]. Arq Bras Endocrinol Metabol. 2009;53:1157-66 pubmed
    ..This disease is often wrongly diagnosed as Grave's disease, and the ablative therapy is frequently conducted prior to the diagnosis...
  8. Mohanty A, Trujillo Y. Virilization and left adnexal mass in a 35-year-old woman. Steroid cell tumor of ovary. Arch Pathol Lab Med. 2006;130:113-4 pubmed
  9. Sasano H, Suzuki T. [Paraneoplastic endocrine syndrome]. Nihon Rinsho. 2006;Suppl 3:328-32 pubmed
  10. Rossi G. Surgically correctable hypertension caused by primary aldosteronism. Best Pract Res Clin Endocrinol Metab. 2006;20:385-400 pubmed
  11. Ohike N, Nagasaki K. [Ectopic neurotensin-producing tumors]. Nihon Rinsho. 2006;Suppl 3:271-3 pubmed
  12. Lenzini L, Caroccia B, Campos A, Fassina A, Belloni A, Seccia T, et al. Lower expression of the TWIK-related acid-sensitive K+ channel 2 (TASK-2) gene is a hallmark of aldosterone-producing adenoma causing human primary aldosteronism. J Clin Endocrinol Metab. 2014;99:E674-82 pubmed publisher
    ..The molecular mechanisms of primary aldosteronism, a common cause of human hypertension, are unknown, but alterations of K(+) channels can play a key role...
  13. Ferlito A, Elsheikh M, Manni J, Rinaldo A. Paraneoplastic syndromes in patients with primary head and neck cancer. Eur Arch Otorhinolaryngol. 2007;264:211-22 pubmed
    ..These syndromes can follow the clinical course of the tumor and thus be useful for monitoring its evolution...
  14. Naumann U, Kaser L, Vetter W. [Incidentaloma (adrenal). Chief symptoms: incidental radiologically detected, asymptomatic adrenal space occupying (mostly) > 1 cm]. Praxis (Bern 1994). 2007;96:1009-14; quiz 1015-6 pubmed
  15. Reincke M, Allolio B, Deuss U, Winkelmann W. Gel chromatographic characterization of immunoreactive adrenocorticotropin in patients with ACTH hypersecretion. Klin Wochenschr. 1989;67:1096-100 pubmed
    ..We conclude that secretion of high molecular weight forms of ACTH is not a unique feature of the ectopic ACTH syndrome.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. Rickman T, Garmany R, Doherty T, Benson D, Okusa M. Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. Am J Kidney Dis. 2001;37:838-46 pubmed
    ..In this case report, we describe an unusual tumor associated with ectopic ACTH and CRH production and the pharmacodynamic relationship of plasma cortisol levels and urinary cortisol excretion with ketoconazole treatment...
  17. Bartel Friedrich S, Saeger W, Friedrich R, Laas R. [Immunohistochemical detection of hormones in hypophyseal adenomas of the rat after fractionated irradiation]. Laryngorhinootologie. 2001;80:257-62 pubmed
    ..The aim of this study was to determine the hormones produced in pituitary gland tumours (TM) following fractionated external irradiation in rats. The TM arose in the course of studies on other questions of radiation effects...
  18. Cuccurullo V, Cascini G, Tamburrini O, Mansi L, Rotondo A. Less frequent requests for In-111 pentreotide and its brothers of endocrinological interest. Minerva Endocrinol. 2011;36:41-52 pubmed
    ..The incremental value of PET-CT with Ga-68 peptides is hypothesized to reduce the number of unknown neoplastic lesions frequently present in patients with PNS...
  19. Rossi G, Errico G, Perez P, Rossi G, Paltrinieri S. Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma. Vet Clin Pathol. 2010;39:480-4 pubmed publisher
    ..Hyperglycemia associated with diabetes was pronounced after excision of the tumor and had been masked by the paraneoplastic effect of the tumor...
  20. Yaturu S, Harrara E, Nopajaroonsri C, Singal R, Gill S. Gynecomastia attributable to human chorionic gonadotropin-secreting giant cell carcinoma of lung. Endocr Pract. 2003;9:233-5 pubmed
    ..To describe a patient with human chorionic gonadotropin (hCG)-secreting giant cell carcinoma of the lung manifesting as painful gynecomastia, which resolved after surgical treatment...
  21. Tahara H. [Ectopic calcitonin-producing tumor]. Nihon Rinsho. 2006;Suppl 3:287-90 pubmed
  22. Suzuki M, Takamizawa S, Enomoto A. [Ectopic erythropoietin-producing tumor]. Nihon Rinsho. 2006;Suppl 3:283-6 pubmed
  23. Hubold C, Brabant G. [Ectopic hormone secretion by neuroendocrine tumors]. Internist (Berl). 2012;53:145-51 pubmed publisher
    ..Therapeutically a curative approach is the primary goal but in advanced tumors palliative treatment aims to control symptoms with the help of specific antihormonal compounds, such as somatostatin analogues...
  24. Bojahr B, Straube W, Reddemann H. [Case observations on the significance of early pregnancy factor as a tumor marker]. Zentralbl Gynakol. 1993;115:125-8 pubmed
  25. Toro C, Rinaldo A, Silver C, Politi M, Ferlito A. Paraneoplastic syndromes in patients with nasopharyngeal cancer. Auris Nasus Larynx. 2009;36:513-20 pubmed publisher
    ..While some PNS will respond to direct treatment, most often the PNS subsides in parallel to response of the NPC, and thus may be useful for monitoring tumor response or recurrence...
  26. Lokaj P, Krivan L. [SIADH as only paraneoplastic cause of the small cell lung cancer]. Vnitr Lek. 2008;54:273-5 pubmed
    ..We searched for the cause of that syndrome and finally we found that the cause of that syndrome was small cell lung cancer with an expansion into the mediastinum and metastases into the skelet...
  27. Okumura M, Fujii Y, Shiono H, Inoue M, Minami M, Utsumi T, et al. Immunological function of thymoma and pathogenesis of paraneoplastic myasthenia gravis. Gen Thorac Cardiovasc Surg. 2008;56:143-50 pubmed publisher
    ..In addition, studying the biology of thymoma is also expected to contribute to further understanding of T-cell development and immunological tolerance in the human, because thymoma can be considered an acquired thymus...
  28. Pfeilschifter J. [Disordered hormone regulation in gynecomastia]. Kongressbd Dtsch Ges Chir Kongr. 2002;119:743-7 pubmed
    ..Evaluation includes a careful patient's history, physical examination of sexual characteristics and the breast tissue, and measurements of serum LH, FSH, testosterone, estradiol, hCG-beta, TSH and tests of liver and kidney function...
  29. Brignardello E, Manti R, Papotti M, Allia E, Campra D, Isolato G, et al. Ectopic secretion of LH by an endocrine pancreatic tumor. J Endocrinol Invest. 2004;27:361-5 pubmed
    ..Testosterone was slightly below normal, but the patient reported an increase of libido. This is an unusual case of ectopic secretion of LH from an endocrine tumor of the pancreas...
  30. Yen Y, Chu P, Feng W. Paraneoplastic syndromes in cancer: Case 3. Parathyroid hormone-related hypercalcemia in cholangiocarcinoma. J Clin Oncol. 2004;22:2244-5 pubmed
  31. Hayashi S. [Genesis and progression of ectopic hormone-producing tumors]. Nihon Rinsho. 2004;62:848-50 pubmed
  32. Saunders S, Vora J. Endocrine evaluation of pituitary tumours. Br J Neurosurg. 2008;22:602-8 pubmed publisher
    ..The commonest problems, as well as the more controversial issues, are discussed and relevant, interesting papers on the topic are highlighted...
  33. Watanobe H, Yoshioka M, Takebe K. Ectopic ACTH syndrome due to Grawitz tumor. Horm Metab Res. 1988;20:453-6 pubmed
    ..We authors believe that this is the first documented case of ACTH-producing Grawitz tumor in the literature...
  34. Griva M, Kubanek J. [Syndrome of inappropriate antidiuretic hormone secretion in non-differentiated small cell lung cancer]. Vnitr Lek. 2002;48:993-5 pubmed
    ..It is also known that some pharmaceutical preparations stimulate the output of antidiuretic hormone or potentiate its effect...
  35. Knosp E, Perneczky A, Kitz K, Grunert P, Wild A. The need for adjunctive focused radiation therapy in pituitary adenomas. Acta Neurochir Suppl. 1995;63:81-4 pubmed
    ..In patients with residual tumour due to non functioning adenomas, radiation therapy should only be given if the proliferation rate is high...
  36. Pross M, Manger T, Heres F, Klose S, Lehnert H, Ridwelski K, et al. [Laparoscopic adrenalectomy--experiences with transperitoneal approach]. Zentralbl Chir. 2002;127:610-3 pubmed
    ..We report our results of laparoscopic anterior transperitoneal adrenalectomy...
  37. Gallwitz W, Guise T, Mundy G. Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo. J Clin Invest. 2002;110:1559-72 pubmed
    ..These results suggest that the PTHrP gene promoter may be a suitable target for treating the skeletal effects of malignancy...
  38. Pasquini E, Faustini Fustini M, Sciarretta V, Saggese D, Roncaroli F, Serra D, et al. Ectopic TSH-secreting pituitary adenoma of the vomerosphenoidal junction. Eur J Endocrinol. 2003;148:253-7 pubmed
    ..We describe an unusual case of ectopic TSH-secreting pituitary adenoma arising from the vomerosphenoidal junction...
  39. Yamaguchi K. [Ectopic hormone-producing tumors--research and clinics]. Nihon Rinsho. 2004;62:983-6 pubmed
    ..It is reasonable to postulate that the clinical entities covered by the term 'ectopic humoral syndrome' will be increasing...
  40. Ohira S, Itoh K, Shiozawa T, Horiuchi A, Ono K, Takeuchi H, et al. Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone-related hypercalcemia. Int J Gynecol Pathol. 2004;23:393-7 pubmed
    ..This is the eleventh case of neuroendocrine carcinoma of non-small cell type associated with surface epithelial neoplasm of the ovary, and the first such tumor to be associated with hypercalcemia...
  41. Morel O, Giraud P, Bernier M, Le Jeune J, Rohmer V, Jallet P. Ectopic acromegaly: localization of the pituitary growth hormone-releasing hormone producing tumor by In-111 pentetreotide scintigraphy and report of two cases. Clin Nucl Med. 2004;29:841-3 pubmed
  42. Bauditz J, Lochs H, Ventz M. [Long-term follow-up of patients with suprasellar germinomas]. Med Klin (Munich). 2007;102:803-8 pubmed
    ..Suprasellar germinomas are rare intracranial neoplasms, which mainly occur in children and adolescents and manifest with endocrine symptoms and/or compression syndromes...
  43. Mazzone P, Arroliga A. Endocrine paraneoplastic syndromes in lung cancer. Curr Opin Pulm Med. 2003;9:313-20 pubmed
    ..Knowledge about the clinical manifestations, pathophysiology, and treatment of these syndromes has evolved over time. This article provides an up-to-date overview of this knowledge...
  44. Beresford L, Fernandez C, Cummings E, Sanderson S, Ming Yu W, Giacomantonio M. Mediastinal polyembryoma associated with Klinefelter syndrome. J Pediatr Hematol Oncol. 2003;25:321-3 pubmed
    ..Most mediastinal germ cell tumors are treated with adjuvant therapy. He was managed with surgical excision alone and is well at 2 years follow-up. The rationale for this approach is discussed...
  45. Muirhead S, Hsu E, Grimard L, Keene D. Endocrine complications of pediatric brain tumors: case series and literature review. Pediatr Neurol. 2002;27:165-70 pubmed
    ..This finding underscores the importance of routine endocrinology follow-up for all brain tumor patients receiving cranial irradiation. Literature review and endocrine surveillance recommendations are included...
  46. Griffiths M, Gama R. Recurrent dizzy spells: all in the head. Ann Clin Biochem. 2005;42:308; author reply 308 pubmed
  47. Beuschlein F, Hammer G. Ectopic pro-opiomelanocortin syndrome. Endocrinol Metab Clin North Am. 2002;31:191-234 pubmed
    ..Diagnostic imaging, including conventional radiological techniques and somatostatin receptor scintigraphy, aids in the correct localization and eventual treatment of ectopic POMC production...
  48. Reschke K, Klose S, Mohnike K, Buhtz P, Roessner A, Lehnert H. [Manifestation of Cushing syndrome and osteoporotic fractures in pregnancy in a patient with Carney complex]. Med Klin (Munich). 2002;97:91-5 pubmed
    ..Besides very clear clinical signs of hypercortisolism, multiple hyperpigmentations and naevi in the patient's face including the lips and the conjunctiva of the right eye were visible, suggesting a Carney complex...
  49. Oberg K. Pancreatic endocrine tumors. Semin Oncol. 2010;37:594-618 pubmed publisher
    ..In the future, treatment will be based on tumor biology and molecular genetics with the aim of so-called personalized medicine...
  50. Capella C, Uccella S, Albarello L, Feltri M, La Rosa S. [Diagnostic criteria and classification of gastro-intestinal pancreatic endocrine tumors]. Minerva Endocrinol. 2001;26:103-10 pubmed
    ..In addition, the main functional types of ETs of the pancreas, stomach, duodenum, jejunum, ileum, appendix and large bowel are briefly described...
  51. Ganz J, Backlund E, Thorsen F. The effects of Gamma Knife surgery of pituitary adenomas on tumor growth and endocrinopathies. Stereotact Funct Neurosurg. 1993;61 Suppl 1:30-7 pubmed
    ..These results are discussed in respect of dose and tumor size. It is suggested that the role of the Gamma Knife in the treatment of pituitary adenomas requires further clarification, based on prospective studies...
  52. Abe T. [Ectopic renin-producing tumor]. Nihon Rinsho. 2006;Suppl 3:313-6 pubmed
  53. Sparagana M, Ackerman L. Positive iodine-131 6 beta-iodomethyl-19-norcholesterol (NP-59) adrenal images can precede return of adrenocortical function after o,p' DDD treatment. Clin Nucl Med. 1988;13:348-51 pubmed
    ..Serial NP-59 adrenal images can anticipate the recurrence of Cushing's syndrome after adrenolytic therapy, thereby permitting early retreatment...