adrenocortical adenoma

Summary

Summary: A benign neoplasm of the ADRENAL CORTEX. It is characterized by a well-defined nodular lesion, usually less than 2.5 cm. Most adrenocortical adenomas are nonfunctional. The functional ones are yellow and contain LIPIDS. Depending on the cell type or cortical zone involved, they may produce ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE.

Top Publications

  1. Nigawara T, Sakihara S, Kageyama K, Terui K, Takayasu S, Hatakeyama S, et al. Endothelial cyst of the adrenal gland associated with adrenocortical adenoma: preoperative images simulate carcinoma. Intern Med. 2009;48:235-40 pubmed
    ..Histopathologically, this lesion was a thick hyaline-walled endothelial cyst, flanked with a compressed adrenocortical adenoma. The puzzling image resemblance of a variation of adrenal cyst to carcinoma necessitated histological ..
  2. Giordano T. Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas. Endocr Pathol. 2006;17:355-63 pubmed
    ..Here, the relevant molecular pathology of adrenal cortical tumors is reviewed with special reference to those methods (e.g., DNA microarrays) that hold promise for improved diagnosis and prognosis, and prediction of therapeutic response...
  3. Ye P, Mariniello B, Mantero F, Shibata H, Rainey W. G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism. J Endocrinol. 2007;195:39-48 pubmed
    ..There are also sporadic increased expressions of these genes in the CPAs. Together, these findings suggest a potential role of altered GPCR expression in many cases of PA and provide candidate GPCR for further study...
  4. Pang T, Bambach C, Monaghan J, Sidhu S, Bune A, Delbridge L, et al. Outcomes of laparoscopic adrenalectomy for hyperaldosteronism. ANZ J Surg. 2007;77:768-73 pubmed
    ..The aim of this study was to investigate the long-term results of laparoscopic adrenalectomy in the control of hypertension caused by primary hyperaldosteronism...
  5. Lumachi F, Ermani M, Basso S, Armanini D, Iacobone M, Favia G. Long-term results of adrenalectomy in patients with aldosterone-producing adenomas: multivariate analysis of factors affecting unresolved hypertension and review of the literature. Am Surg. 2005;71:864-9 pubmed
  6. Toniato A, Bernante P, Rossi G, Pelizzo M. The role of adrenal venous sampling in the surgical management of primary aldosteronism. World J Surg. 2006;30:624-7 pubmed
    ..Identification of a unilateral overproduction of aldosterone due to Conn's adenoma or unilateral hyperplasia is of utmost importance to the surgeon...
  7. Sarwar Z, Ward V, Mooney D, Testa S, Taylor G. Congenital adrenocortical adenoma: case report and review of literature. Pediatr Radiol. 2004;34:991-4 pubmed
    ..We have not found any reported case with a histological diagnosis of a congenital adrenocortical adenoma. We present this case of a congenital adrenocortical neoplasm with histological findings consistent with ..
  8. Bollito E, Papotti M, Porpiglia F, Terzolo M, Cracco C, Cappia S, et al. Myxoid adrenocortical adenoma with a pseudoglandular pattern. Virchows Arch. 2004;445:414-8 pubmed
    ..Limited areas of classical adrenocortical adenoma were detected in less than 20% of the tumour area...
  9. Young W. Clinical practice. The incidentally discovered adrenal mass. N Engl J Med. 2007;356:601-10 pubmed

More Information

Publications62

  1. Zarnegar R, Young W, Lee J, Sweet M, Kebebew E, Farley D, et al. The aldosteronoma resolution score: predicting complete resolution of hypertension after adrenalectomy for aldosteronoma. Ann Surg. 2008;247:511-8 pubmed publisher
    ..To develop a prediction model using information readily available, at clinical presentation, which could determine whether patients with aldosterone-producing adenomas would have complete resolution of hypertension after adrenalectomy...
  2. Schmitz K, Helwig J, Bertram S, Sheu S, Suttorp A, Seggewiss J, et al. Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours. J Clin Pathol. 2011;64:529-35 pubmed publisher
    ..The tremendous potential of microRNAs (miRNAs) as diagnostic biomarkers in surgical pathology has recently been shown in a broad variety of tumours...
  3. Lepoutre Lussey C, Rousseau A, Al Ghuzlan A, Amar L, Hignette C, Cioffi A, et al. Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional combined tumor. Eur J Endocrinol. 2012;166:131-5 pubmed publisher
    ..Primary adrenal angiosarcoma is an extremely rare neoplasm, as are combined tumors within a given adrenal lesion...
  4. Onoda N, Ishikawa T, Nishio K, Tahara H, Inaba M, Wakasa K, et al. Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case. Endocr J. 2009;56:495-502 pubmed
    ..We diagnosed that the present case had 1) cortisol-producing right adrenocortical adenoma, 2) aldosterone producing left adrenocortical adenoma, and 3) cortical minute nodules with aldosterone ..
  5. Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen H, Lichtenauer U, et al. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet. 2013;45:440-4, 444e1-2 pubmed publisher
    ..In summary, dominant somatic alterations in two members of the ATPase gene family result in autonomous aldosterone secretion...
  6. Inan N, Arslan A, Akansel G, Anik Y, Balci N, Demirci A. Dynamic contrast enhanced MRI in the differential diagnosis of adrenal adenomas and malignant adrenal masses. Eur J Radiol. 2008;65:154-62 pubmed
    ..To evaluate the value of dynamic MR imaging in the differential diagnosis of adrenal adenomas and malignant tumors, especially in cases with atypical adenomas...
  7. Kimura M, Irie A, Minei S, Ishii J, Okawa A, Takashima R, et al. [A case of adrenocortical adenoma coexisting with gastrointestinal stromal tumor]. Hinyokika Kiyo. 2007;53:551-5 pubmed
    ..Histopathological diagnosis was coincident with gastric GIST and right adrenocortical adenoma, and the GIST was diagnosed as a high risk tumor because its diameter was over 5 cm.
  8. Young W. Primary aldosteronism: renaissance of a syndrome. Clin Endocrinol (Oxf). 2007;66:607-18 pubmed
    ..In bilateral adrenal forms of primary aldosteronism, unilateral or bilateral adrenalectomy seldom corrects the hypertension and they should be treated medically with a mineralocorticoid receptor antagonist...
  9. Louiset E, Gobet F, Libe R, Horvath A, Renouf S, Cariou J, et al. ACTH-independent Cushing's syndrome with bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma. J Clin Endocrinol Metab. 2010;95:18-24 pubmed publisher
    Bilateral micronodular adrenal hyperplasia and ectopic adrenocortical adenoma are two rare causes of ACTH-independent Cushing's syndrome.
  10. McKenzie T, Lillegard J, Young W, Thompson G. Aldosteronomas--state of the art. Surg Clin North Am. 2009;89:1241-53 pubmed publisher
    ..Patients with IHA, or those not amenable or agreeable to surgery, are best managed with a MR antagonist...
  11. Walz M, Gwosdz R, Levin S, Alesina P, Suttorp A, Metz K, et al. Retroperitoneoscopic adrenalectomy in Conn's syndrome caused by adrenal adenomas or nodular hyperplasia. World J Surg. 2008;32:847-53 pubmed publisher
    ..In patients with primary hyperaldosteronism, solitary adrenal adenomas are an indication for surgical intervention. In contrast, adrenal hyperplasia is almost exclusively treated by drugs...
  12. Zhu H, Dai Y, Wang O, Li M, Lu L, Zhao W, et al. Generalized glucocorticoid resistance accompanied with an adrenocortical adenoma and caused by a novel point mutation of human glucocorticoid receptor gene. Chin Med J (Engl). 2011;124:551-5 pubmed
    ..The purpose of this study was to explore the genetic disorder of glucocorticoid resistance syndrome...
  13. Scholl U, Lifton R. New insights into aldosterone-producing adenomas and hereditary aldosteronism: mutations in the K+ channel KCNJ5. Curr Opin Nephrol Hypertens. 2013;22:141-7 pubmed publisher
  14. Oki K, Yamane K, Sakashita Y, Kamei N, Watanabe H, Toyota N, et al. Primary aldosteronism and hypercortisolism due to bilateral functioning adrenocortical adenomas. Clin Exp Nephrol. 2008;12:382-387 pubmed publisher
  15. Ishida M, Yoshida K, Miyamoto K, Iwai M, Miyahira Y, Kushima R, et al. Cytological features of myxoid adrenocortical adenoma with a pseudoglandular component: a case report with differential diagnostic considerations. Diagn Cytopathol. 2008;36:576-80 pubmed publisher
    ..We report here the first cytopathological study of a myxoid adrenocortical adenoma with a pseudoglandular component, contributing especially to the differential diagnosis from metastatic ..
  16. Medeau V, Moreau F, Trinquart L, Clemessy M, Wemeau J, Vantyghem M, et al. Clinical and biochemical characteristics of normotensive patients with primary aldosteronism: a comparison with hypertensive cases. Clin Endocrinol (Oxf). 2008;69:20-8 pubmed publisher
    ..It is unknown why some patients with biochemical evidence of primary aldosteronism (PA) do not develop hypertension. We aimed to compare clinical and biochemical characteristics of normotensive and hypertensive patients with PA...
  17. Tamura Y, Adachi J, Chiba Y, Mori S, Takeda K, Kasuya Y, et al. Primary aldosteronism due to unilateral adrenal microadenoma in an elderly patient: efficacy of selective adrenal venous sampling. Intern Med. 2008;47:37-42 pubmed
    ..The histopathological findings demonstrated the aldosterone-producing microadenoma with secondary micronodules. In conclusion, SAVS should be performed to determine the laterality of PA with obscure CT imaging...
  18. Lau S, Weiss L. The Weiss system for evaluating adrenocortical neoplasms: 25 years later. Hum Pathol. 2009;40:757-68 pubmed publisher
    ..The Weiss system, first introduced 25 years ago, provides specific guidelines for differentiating adrenocortical adenoma from adrenocortical carcinoma and is considered the standard for determining malignancy in tumors of the ..
  19. Sakamoto N, Tojo K, Saito T, Fujimoto K, Isaka T, Tajima N, et al. Coexistence of aldosterone-producing adrenocortical adenoma and pheochromocytoma in an ipsilateral adrenal gland. Endocr J. 2009;56:213-9 pubmed
    ..selective adrenal venous sampling with intravenous ACTH infusion indicated aldosterone-producing adrenocortical adenoma (APA) in left adrenal gland...
  20. Myint K, Watts M, Appleton D, Lomas D, Jamieson N, Taylor K, et al. Primary hyperaldosteronism due to adrenal microadenoma: a curable cause of refractory hypertension. J Renin Angiotensin Aldosterone Syst. 2008;9:103-6 pubmed publisher
    ..The diagnosis of primary hyperaldosteronism due to microadenoma or unilateral adrenal hyperplasia can be challenging, since hypokalaemic alkalosis, high plasma aldosterone and a definite adenoma on imaging may all be absent...
  21. Tadjine M, Lampron A, Ouadi L, Bourdeau I. Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas. Clin Endocrinol (Oxf). 2008;68:264-70 pubmed
    ..To better understand the role of Wnt/beta-catenin signalling in adrenocortical tumours, we performed mutational analysis of the beta-catenin gene...
  22. Rossi G, Bernini G, Caliumi C, Desideri G, Fabris B, Ferri C, et al. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. J Am Coll Cardiol. 2006;48:2293-300 pubmed
    ..We prospectively investigated the prevalence of curable forms of primary aldosteronism (PA) in newly diagnosed hypertensive patients...
  23. Okura T, Miyoshi K, Watanabe S, Kurata M, Irita J, Manabe S, et al. Coexistence of three distinct adrenal tumors in the same adrenal gland in a patient with primary aldosteronism and preclinical Cushing's syndrome. Clin Exp Nephrol. 2006;10:127-30 pubmed
    ..at 33 years of age, she had been diagnosed with Cushing's syndrome, due to a cortisol-producing adrenocortical adenoma, and she had received a left adrenalectomy. Clinically and pathophysiologically, this was a very rare case.
  24. Anagnostis P, Karagiannis A, Tziomalos K, Kakafika A, Athyros V, Mikhailidis D. Adrenal incidentaloma: a diagnostic challenge. Hormones (Athens). 2009;8:163-84 pubmed
    ..The present review considers the prevalence, pathology and natural history of AIs. We also discuss the reliability of available screening methods and localization techniques and consider optimal management and follow-up strategies...
  25. Honda M, Tsukada T, Horiuchi T, Tanaka R, Yamaguchi K, Obara T, et al. Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene. Intern Med. 2004;43:310-4 pubmed
    ..Further studies demonstrated an enlarged left superior parathyroid gland and a left aldosterone-producing adrenocortical adenoma. Blood pressure was controlled with spironolactone and nifedipine, and left mastectomy was done for breast ..
  26. Choi M, Scholl U, Yue P, Björklund P, Zhao B, Nelson Williams C, et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011;331:768-72 pubmed publisher
    ..These findings explain pathogenesis in a subset of patients with severe hypertension and implicate loss of K(+) channel selectivity in constitutive cell proliferation and hormone production...
  27. Stojadinovic A, Brennan M, Hoos A, Omeroglu A, Leung D, Dudas M, et al. Adrenocortical adenoma and carcinoma: histopathological and molecular comparative analysis. Mod Pathol. 2003;16:742-51 pubmed
    ..Tumor morphology is a better predictor of metastatic risk in ACCa than current immunohistochemistry-detected cell cycle regulatory and proliferation-associated proteins...
  28. Sato H, Igarashi H, Kishimoto Y, Yamaguchi K, Saito T, Ishida H, et al. Combined tumor consisting of non-functioning adrenocortical adenoma and pheochromocytoma in the same gland. Int J Urol. 2002;9:398-401 pubmed
    ..of the tumor was completely encapsulated, with clear cells comprising a honeycomb-like mass, regarded as adrenocortical adenoma. The other part consisted of rich cytoplasma and these basophilic, hyperchromatic cells included alveolar ..
  29. Honda K, Kashima K, Daa T, Gamachi A, Nakayama I, Yokoyama S. Myxoid adrenal cortical adenoma. Pathol Int. 2001;51:887-91 pubmed
  30. Rossi E, Sani C, Perazzoli F, Casoli M, Negro A, Dotti C. Alterations of calcium metabolism and of parathyroid function in primary aldosteronism, and their reversal by spironolactone or by surgical removal of aldosterone-producing adenomas. Am J Hypertens. 1995;8:884-93 pubmed
  31. Ito H, Sasaoka A, Takao T, Nishiya K, Nanamiya W, Chikazawa H, et al. Aldosterone-producing adrenocortical adenoma complicated by chronic renal failure. Case report and review of the literature. Am J Nephrol. 1998;18:541-6 pubmed
    ..hormone, cortisol, aldosterone levels and PRA were compatible with aldosterone-producing adrenocortical adenoma. After administration of spironolactone and manidipine hydrochloride, a calcium antagonist, general ..
  32. Fendrich V, Ramaswamy A, Nies C. [Hyperaldosteronism persisting after subtotal adrenalectomy]. Chirurg. 2003;74:473-7 pubmed
    ..Total adrenalectomy is the standard procedure. In contrast to bilateral adrenal diseases (e.g., MEN II pheochromocytomas), there is no consensus about the effect of subtotal adrenalectomy...
  33. Fukushima A, Okada Y, Tanikawa T, Kawahara C, Misawa H, Kanda K, et al. Virilizing adrenocortical adenoma with Cushing's syndrome, thyroid papillary carcinoma and hypergastrinemia in a middle-aged woman. Endocr J. 2003;50:179-87 pubmed
    We report a rare case of virilizing adrenocortical adenoma complicated with Cushing's syndrome, thyroid papillary carcinoma and hypergastrinemia...
  34. Shimizu A, Oriuchi N, Tsushima Y, Higuchi T, Aoki J, Endo K. High [18F] 2-fluoro-2-deoxy-D-glucose (FDG) uptake of adrenocortical adenoma showing subclinical Cushing's syndrome. Ann Nucl Med. 2003;17:403-6 pubmed
    ..8, which was higher than usual benign tumors. Histological diagnosis of the resected adrenal tumor was adrenocortical adenoma without evidence of malignancy...
  35. Dundr P, Novák K. Pseudoglandular myxoid adenoma of the adrenal gland. Pathol Res Pract. 2003;199:493-6 pubmed
    ..In addition, after extensive examination, we found foci of typical adrenocortical adenoma. Grossly, the tumor was yellowish without discernable gelatinous changes...
  36. Sugawara A, Takeuchi K, Suzuki T, Itoi K, Sasano H, Ito S. A case of aldosterone-producing adrenocortical adenoma associated with a probable post-operative adrenal crisis: histopathological analyses of the adrenal gland. Hypertens Res. 2003;26:663-8 pubmed
    We describe a case of aldosterone-producing adrenocortical adenoma (APA) associated with a probable post-operative adrenal crisis possibly due to subtle autonomous cortisol secretion...
  37. Dutta R, Welander J, Brauckhoff M, Walz M, Alesina P, Arnesen T, et al. Complementary somatic mutations of KCNJ5, ATP1A1, and ATP2B3 in sporadic aldosterone producing adrenal adenomas. Endocr Relat Cancer. 2014;21:L1-4 pubmed publisher
  38. Shigematsu K, Nakagaki T, Yamaguchi N, Kawai K, Sakai H, Takahara O. Analysis of mRNA expression for steroidogenic enzymes in the remaining adrenal cortices attached to adrenocortical adenomas. Eur J Endocrinol. 2008;158:867-78 pubmed publisher
  39. Weiner I. Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism. Semin Nephrol. 2013;33:265-76 pubmed publisher
  40. Akerström T, Crona J, Delgado Verdugo A, Starker L, Cupisti K, Willenberg H, et al. Comprehensive re-sequencing of adrenal aldosterone producing lesions reveal three somatic mutations near the KCNJ5 potassium channel selectivity filter. PLoS ONE. 2012;7:e41926 pubmed publisher
    ..The prevalence and spectrum of KCNJ5 mutations in different entities of adrenocortical lesions remain to be defined...
  41. Hamamatsu A, Arai T, Iwamoto M, Kato T, Sawabe M. Adenomatoid tumor of the adrenal gland: case report with immunohistochemical study. Pathol Int. 2005;55:665-9 pubmed
    ..Immunohistochemistry of estrogen, progesterone and androgen receptors was negative. These findings confirm mesothelial origin of the tumor and suggest that this tumor has little relation to sex hormone despite male predominance...
  42. Fuessl H. [Primary hyperaldosteronism. Not an exotic cause of hypertension]. MMW Fortschr Med. 2006;148:37, 39-40 pubmed
  43. Sbiera S, Schmull S, Assie G, Voelker H, Kraus L, Beyer M, et al. High diagnostic and prognostic value of steroidogenic factor-1 expression in adrenal tumors. J Clin Endocrinol Metab. 2010;95:E161-71 pubmed publisher
  44. Cordera F, Grant C, van Heerden J, Thompson G, Young W. Androgen-secreting adrenal tumors. Surgery. 2003;134:874-80; discussion 880 pubmed
    ..Adrenal tumors that secrete androgens exclusively are extraordinarily rare. The aim of this study was to characterize patients with pure androgen-secreting adrenal tumors...
  45. Magro G, Esposito G, Cecchetto G, Dall Igna P, Marcato R, Gambini C, et al. Pediatric adrenocortical tumors: morphological diagnostic criteria and immunohistochemical expression of matrix metalloproteinase type 2 and human leucocyte-associated antigen (HLA) class II antigens. Results from the Italian Pediatric Rare Tumor (TR. Hum Pathol. 2012;43:31-9 pubmed publisher
    ..Although pediatric adrenocortical tumors seem to be similar histologically to their adult counterparts, it is likely that they have distinctive molecular features...
  46. Singh P, Soon P, Feige J, Chabre O, Zhao J, Cherradi N, et al. Dysregulation of microRNAs in adrenocortical tumors. Mol Cell Endocrinol. 2012;351:118-28 pubmed publisher
    ..In this review we summarize the current understanding of miRNAs in adrenocortical tumors, and highlight their potential in differentiating between ACCs and ACAs, risk stratification and prognosis...
  47. Sheikh A, Haque N, Zuberi L, Jamal A. Laparoscopic adrenalectomy for Conn's syndrome. J Coll Physicians Surg Pak. 2006;16:76-8 pubmed
    ..Two cases of endocrine hypertension, due to Conn s syndrome, undergoing laparoscopic adrenalectomy for the first time here, are reported...
  48. Ragnarsson O, Berglund P, Eder D, Johannsson G. Long-term cognitive impairments and attentional deficits in patients with Cushing's disease and cortisol-producing adrenal adenoma in remission. J Clin Endocrinol Metab. 2012;97:E1640-8 pubmed publisher
    ..Cognitive function is impaired in patients with active Cushing's syndrome (CS)...
  49. Vesin C, Chabre O, Mallion J, Chaffanjon P, Sturm N, Baguet J. [Diagnosis and post-operative evolution of patients operated for adrenal adenoma (Conn syndrome). A 12-years retrospective study]. Arch Mal Coeur Vaiss. 2007;100:121-5 pubmed
    ..2) There is probably an underdiagnosis of adrenal adenoma (Conn syndrome) because neither adenomas with normokaliemia, nor adenomas <10 mm in scanner imaging have ever been diagnosed or at least, sent to surgery...
  50. Halefoglu A, Bas N, Yasar A, Basak M. Differentiation of adrenal adenomas from nonadenomas using CT histogram analysis method: a prospective study. Eur J Radiol. 2010;73:643-51 pubmed publisher
    ..The objective of our study was to prospectively evaluate the effectiveness of computed tomography (CT) histogram analysis method in the differentiation of benign and malignant adrenal masses...
  51. Gockel I, Kneist W, Heintz A, Beyer J, Junginger T. Endoscopic adrenalectomy: an analysis of the transperitoneal and retroperitoneal approaches and results of a prospective follow-up study. Surg Endosc. 2005;19:569-73 pubmed
    ..The aim of this study was to determine which of these is the optimal surgical technique in a prospectively designed analysis of a large series of patients operated on by a single team over a 10-year period...
  52. Shevchenko I, Vetshev P, KOvalenko E, Vetshev S. [The long-term results of the dynamic observation of patients with adrenal gland adenomas]. Klin Med (Mosk). 2006;84:57-62 pubmed
    ..The study established more precise indications to dynamic observation and its algorithm...
  53. Nakamura M, Miki Y, Akahira J, Morimoto R, Satoh F, Ishidoya S, et al. An analysis of potential surrogate markers of target-specific therapy in archival materials of adrenocortical carcinoma. Endocr Pathol. 2009;20:17-23 pubmed publisher
    ..signal-regulated kinase and phosphatidylinositol-3 kinase/Akt pathways, in 41 ACC cases, 54 adrenocortical adenoma (ACA) cases, and five nonpathological adrenal glands and correlated the findings with clinicopathological ..