adrenal cortex neoplasms

Summary

Summary: Tumors or cancers of the ADRENAL CORTEX.

Top Publications

  1. Fassnacht M, Libe R, Kroiss M, Allolio B. Adrenocortical carcinoma: a clinician's update. Nat Rev Endocrinol. 2011;7:323-35 pubmed publisher
    ..New targeted therapies, for example, IGF-1 receptor inhibitors, are under investigation and may soon improve current treatment options...
  2. Fassnacht M, Kroiss M, Allolio B. Update in adrenocortical carcinoma. J Clin Endocrinol Metab. 2013;98:4551-64 pubmed publisher
    ..The ongoing international efforts including comprehensive "-omic approaches" and next-generation sequencing will improve our understanding of the pathogenesis and hopefully lead to better therapies. ..
  3. Scholl U, Lifton R. New insights into aldosterone-producing adenomas and hereditary aldosteronism: mutations in the K+ channel KCNJ5. Curr Opin Nephrol Hypertens. 2013;22:141-7 pubmed publisher
  4. Bonnet S, Gaujoux S, Launay P, Baudry C, Chokri I, Ragazzon B, et al. Wnt/?-catenin pathway activation in adrenocortical adenomas is frequently due to somatic CTNNB1-activating mutations, which are associated with larger and nonsecreting tumors: a study in cortisol-secreting and -nonsecreting tumors. J Clin Endocrinol Metab. 2011;96:E419-26 pubmed publisher
  5. Fassnacht M, Terzolo M, Allolio B, Baudin E, Haak H, Berruti A, et al. Combination chemotherapy in advanced adrenocortical carcinoma. N Engl J Med. 2012;366:2189-97 pubmed publisher
    ..Adrenocortical carcinoma is a rare cancer that has a poor response to cytotoxic treatment...
  6. Letouze E, Rosati R, Komechen H, Doghman M, Marisa L, Flück C, et al. SNP array profiling of childhood adrenocortical tumors reveals distinct pathways of tumorigenesis and highlights candidate driver genes. J Clin Endocrinol Metab. 2012;97:E1284-93 pubmed publisher
    ..To date, copy number alterations in these tumors have only been analyzed by low-resolution comparative genomic hybridization...
  7. Choi M, Scholl U, Yue P, Björklund P, Zhao B, Nelson Williams C, et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science. 2011;331:768-72 pubmed publisher
    ..These findings explain pathogenesis in a subset of patients with severe hypertension and implicate loss of K(+) channel selectivity in constitutive cell proliferation and hormone production...
  8. Bussey K, Demeure M. Toward a pathway-centered approach for the treatment of adrenocortical carcinoma. Curr Opin Oncol. 2011;23:34-44 pubmed publisher
    ..The rarity of the disease has stymied therapeutic development. Recent work toward understanding the molecular pathogenesis of the disease has identified several potential new diagnostic and therapeutic targets...
  9. Patterson E, Holloway A, Weng J, Fojo T, Kebebew E. MicroRNA profiling of adrenocortical tumors reveals miR-483 as a marker of malignancy. Cancer. 2011;117:1630-9 pubmed publisher
    ..The aim of this study was to identify microRNAs (miRNAs or miRs) that are differentially expressed in malignant adrenocortical tumors as compared with benign tumors and assess their potential as diagnostic predictors...

More Information

Publications62

  1. Saad R, Marsault S, Coloby P. [Adrenocortical oncocytic cells tumor: case report and review of literature]. Prog Urol. 2011;21:288-90 pubmed publisher
    ..All tumors were cured by surgery. Management and follow-up were established upon prognosis...
  2. Durand J, Lampron A, Mazzuco T, Chapman A, Bourdeau I. Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations. J Clin Endocrinol Metab. 2011;96:E1206-11 pubmed publisher
    ..Mutations of ?-catenin gene (CTNNB1) are frequent in adrenocortical adenomas (AA) and adrenocortical carcinomas (ACC). However, the target genes of ?-catenin have not yet been identified in adrenocortical tumors...
  3. Klein J, Turner C, Gray F, Yu D, Kozakewich H, Perez Atayde A, et al. Adrenal cortical tumors in children: factors associated with poor outcome. J Pediatr Surg. 2011;46:1201-7 pubmed publisher
    ..The purpose of this study was to evaluate recurrence and survival outcomes in pediatric adrenal cortical neoplasms...
  4. Mwandila M, Waller H, Stott V, Mercer P. A case of a testosterone-secreting oncocytic adrenocortical carcinoma. N Z Med J. 2010;123:80-2 pubmed
    ..This is the first case presented of a testosterone-secreting oncocytic adrenocortical carcinoma...
  5. Wasserman J, Zambetti G, Malkin D. Towards an understanding of the role of p53 in adrenocortical carcinogenesis. Mol Cell Endocrinol. 2012;351:101-10 pubmed publisher
  6. Rechache N, Wang Y, Stevenson H, Killian J, Edelman D, Merino M, et al. DNA methylation profiling identifies global methylation differences and markers of adrenocortical tumors. J Clin Endocrinol Metab. 2012;97:E1004-13 pubmed publisher
    ..It is not known whether there are any DNA methylation alterations in adrenocortical tumors...
  7. Tissier F. Classification of adrenal cortical tumors: what limits for the pathological approach?. Best Pract Res Clin Endocrinol Metab. 2010;24:877-85 pubmed publisher
  8. Almeida M, Harran M, Bimpaki E, Hsiao H, Horvath A, Cheadle C, et al. Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions. J Clin Endocrinol Metab. 2011;96:E728-38 pubmed publisher
    ..Massive macronodular adrenocortical disease or ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a clinically and genetically heterogeneous disorder...
  9. Ozata D, Caramuta S, Velazquez Fernandez D, Akçakaya P, Xie H, Höög A, et al. The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma. Endocr Relat Cancer. 2011;18:643-55 pubmed publisher
  10. Ragazzon B, Assie G, Bertherat J. Transcriptome analysis of adrenocortical cancers: from molecular classification to the identification of new treatments. Endocr Relat Cancer. 2011;18:R15-27 pubmed publisher
    ..The potential for both ACC diagnosis and the identification of new therapeutic targets will be discussed...
  11. Arlt W, Biehl M, Taylor A, Hahner S, Libe R, Hughes B, et al. Urine steroid metabolomics as a biomarker tool for detecting malignancy in adrenal tumors. J Clin Endocrinol Metab. 2011;96:3775-84 pubmed publisher
    ..Differentiating ACC from adrenocortical adenoma (ACA) represents a diagnostic challenge in patients with adrenal incidentalomas, with tumor size, imaging, and even histology all providing unsatisfactory predictive values...
  12. Custodio G, Komechen H, Figueiredo F, Fachin N, Pianovski M, Figueiredo B. Molecular epidemiology of adrenocortical tumors in southern Brazil. Mol Cell Endocrinol. 2012;351:44-51 pubmed publisher
    ..Curative resection is possible when a small ACT is detected early...
  13. Jain M, Rechache N, Kebebew E. Molecular markers of adrenocortical tumors. J Surg Oncol. 2012;106:549-56 pubmed publisher
    ..In this review, we highlight recent advances in the molecular diagnosis of adrenocortical tumors...
  14. Fonseca A, Kugelberg J, Starker L, Scholl U, Choi M, Hellman P, et al. Comprehensive DNA methylation analysis of benign and malignant adrenocortical tumors. Genes Chromosomes Cancer. 2012;51:949-60 pubmed publisher
    ..Genes with altered DNA methylation patterns were identified of putative importance to benign and malignant adrenocortical tumor development...
  15. Else T, Williams A, Sabolch A, Jolly S, Miller B, Hammer G. Adjuvant therapies and patient and tumor characteristics associated with survival of adult patients with adrenocortical carcinoma. J Clin Endocrinol Metab. 2014;99:455-61 pubmed publisher
    ..Studies regarding outcome and prognostic factors rely on fairly small studies. Here we summarize the experience with patients with a diagnosis of adrenocortical carcinoma from a large tertiary referral center...
  16. Costa R, Wesolowski R, Raghavan D. Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?. BJU Int. 2011;108:1546-54 pubmed publisher
    ..Advanced adrenal carcinoma constitutes an orphan disease, with a high mortality rate, and merits investment in clinical trials...
  17. Heaton J, Wood M, Kim A, Lima L, Barlaskar F, Almeida M, et al. Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and ?-catenin. Am J Pathol. 2012;181:1017-33 pubmed publisher
    ..Our results are consistent with a model in which dysregulation of one pathway may result in adrenal hyperplasia, but accumulation of a second or multiple alterations is necessary for tumorigenesis...
  18. Beuschlein F, Boulkroun S, Osswald A, Wieland T, Nielsen H, Lichtenauer U, et al. Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension. Nat Genet. 2013;45:440-4, 444e1-2 pubmed publisher
    ..In summary, dominant somatic alterations in two members of the ATPase gene family result in autonomous aldosterone secretion...
  19. Wang T, Cheung K, Roman S, Sosa J. A cost-effectiveness analysis of adrenalectomy for nonfunctional adrenal incidentalomas: is there a size threshold for resection?. Surgery. 2012;152:1125-32 pubmed publisher
    ..This study evaluates the cost-effectiveness of this approach...
  20. Schmitz K, Helwig J, Bertram S, Sheu S, Suttorp A, Seggewiss J, et al. Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours. J Clin Pathol. 2011;64:529-35 pubmed publisher
    ..The tremendous potential of microRNAs (miRNAs) as diagnostic biomarkers in surgical pathology has recently been shown in a broad variety of tumours...
  21. Lalli E, Doghman M, Latre De Late P, El Wakil A, Mus Veteau I. Beyond steroidogenesis: novel target genes for SF-1 discovered by genomics. Mol Cell Endocrinol. 2013;371:154-9 pubmed publisher
    ..The identification of the complete set of SF-1 target genes will be of great importance to open new avenues for therapeutic intervention in adrenal diseases...
  22. Sbiera S, Kroiss M, Thamm T, Beyer M, Majidi F, Kuehner D, et al. Survivin in adrenocortical tumors - pathophysiological implications and therapeutic potential. Horm Metab Res. 2013;45:137-46 pubmed publisher
    ..In conclusion, our data suggest that survivin could play an important role in the anti-apoptotic mechanisms in ACC and provide first hints that targeting survivin might be an interesting new therapeutic approach in this rare disease...
  23. Barreau O, de Reynies A, Wilmot Roussel H, Guillaud Bataille M, Auzan C, Rene Corail F, et al. Clinical and pathophysiological implications of chromosomal alterations in adrenocortical tumors: an integrated genomic approach. J Clin Endocrinol Metab. 2012;97:E301-11 pubmed publisher
    ..The aim was to evaluate the diagnostic and prognostic value of chromosomal alterations in ACT and to identify genes associated with benign and malignant tumorigenesis...
  24. Ronchi C, Leich E, Sbiera S, Weismann D, Rosenwald A, Allolio B, et al. Single nucleotide polymorphism microarray analysis in cortisol-secreting adrenocortical adenomas identifies new candidate genes and pathways. Neoplasia. 2012;14:206-18 pubmed
    ..Furthermore, they implicate that the Notch1 signaling pathway might be involved in the molecular pathogenesis of adrenocortical tumors...
  25. Lehmann T, Wrzesinski T. The molecular basis of adrenocortical cancer. Cancer Genet. 2012;205:131-7 pubmed publisher
    ..We attempt to understand the role of abnormal cell growth and steroid hormone secretion. Genetic and transcriptome analyses have improved our understanding of ACTs considerably, yet many unanswered questions remain...
  26. Pianovski M, Cavalli L, Figueiredo B, Santos S, Doghman M, Ribeiro R, et al. SF-1 overexpression in childhood adrenocortical tumours. Eur J Cancer. 2006;42:1040-3 pubmed
    ..This data show that SF-1 overexpression is widespread in childhood ACT and is likely to play a role in its pathogenesis...
  27. Juliano J, Cody R, Suh J. Metastatic adrenocortical oncocytoma: a case report. Urol Oncol. 2008;26:198-201 pubmed publisher
    ..The first case of metastatic adrenocortical oncocytoma is reported along with an update of the literature. A role for radiotherapy in the palliative setting is demonstrated...
  28. Bertherat J, Bertagna X. Pathogenesis of adrenocortical cancer. Best Pract Res Clin Endocrinol Metab. 2009;23:261-71 pubmed publisher
  29. Toniato A, Bernante P, Rossi G, Pelizzo M. The role of adrenal venous sampling in the surgical management of primary aldosteronism. World J Surg. 2006;30:624-7 pubmed
    ..Identification of a unilateral overproduction of aldosterone due to Conn's adenoma or unilateral hyperplasia is of utmost importance to the surgeon...
  30. Gruschwitz T, Breza J, Wunderlich H, Junker K. Improvement of histopathological classification of adrenal gland tumors by genetic differentiation. World J Urol. 2010;28:329-34 pubmed publisher
    ..The purpose of this study was to define specific genetic alterations differentiating between adenomas and carcinomas...
  31. Bollito E, Papotti M, Porpiglia F, Terzolo M, Cracco C, Cappia S, et al. Myxoid adrenocortical adenoma with a pseudoglandular pattern. Virchows Arch. 2004;445:414-8 pubmed
  32. Dehner L, Hill D. Adrenal cortical neoplasms in children: why so many carcinomas and yet so many survivors?. Pediatr Dev Pathol. 2009;12:284-91 pubmed publisher
    ..A risk assessment system is proposed that incorporates tumor weight, localization of tumor to the gland without invasion into the surrounding tissues or organs, and absence of metastasis...
  33. Giordano T. Molecular pathology of adrenal cortical tumors: separating adenomas from carcinomas. Endocr Pathol. 2006;17:355-63 pubmed
    ..Here, the relevant molecular pathology of adrenal cortical tumors is reviewed with special reference to those methods (e.g., DNA microarrays) that hold promise for improved diagnosis and prognosis, and prediction of therapeutic response...
  34. Slater E, Diehl S, Langer P, Samans B, Ramaswamy A, Zielke A, et al. Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors. Eur J Endocrinol. 2006;154:587-98 pubmed
    ..The comparative analysis by cDNA microarrays of gene-expression patterns of benign and malignant adrenocortical tumors allows us to identify new tumor-suppressor genes and proto-oncogenes underlying adrenocortical tumorigenesis...
  35. Terzolo M, Bovio S, Reimondo G, Pia A, Osella G, Borretta G, et al. Subclinical Cushing's syndrome in adrenal incidentalomas. Endocrinol Metab Clin North Am. 2005;34:423-39, x pubmed
    ..The authors' aim is to present up-to-date information on the most relevant issues of subclinical Cushing's syndrome by addressing the many uncertainties and controversies surrounding this ill-defined endocrine condition...
  36. Velazquez Fernandez D, Laurell C, Geli J, Höög A, Odeberg J, Kjellman M, et al. Expression profiling of adrenocortical neoplasms suggests a molecular signature of malignancy. Surgery. 2005;138:1087-94 pubmed
    ..Our aim was to investigate the differences in transcriptional profiles between benign and malignant adrenocortical neoplasms using complementary DNA microarray techniques...
  37. Young W. Clinical practice. The incidentally discovered adrenal mass. N Engl J Med. 2007;356:601-10 pubmed
  38. Ye P, Mariniello B, Mantero F, Shibata H, Rainey W. G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism. J Endocrinol. 2007;195:39-48 pubmed
    ..There are also sporadic increased expressions of these genes in the CPAs. Together, these findings suggest a potential role of altered GPCR expression in many cases of PA and provide candidate GPCR for further study...
  39. Rizk Rabin M, Assie G, Rene Corail F, Perlemoine K, Hamzaoui H, Tissier F, et al. Differential expression of parathyroid hormone-related protein in adrenocortical tumors: autocrine/paracrine effects on the growth and signaling pathways in H295R cells. Cancer Epidemiol Biomarkers Prev. 2008;17:2275-85 pubmed publisher
    ..The active synthesis of PTHrP is linked to poor prognosis in ACC, in which it may act as an autocrine/paracrine factor in tumor growth and malignancy...
  40. Adam P, Hahner S, Hartmann M, Heinrich B, Quinkler M, Willenberg H, et al. Epidermal growth factor receptor in adrenocortical tumors: analysis of gene sequence, protein expression and correlation with clinical outcome. Mod Pathol. 2010;23:1596-604 pubmed publisher
  41. Szabó P, Tamasi V, Molnar V, Andrásfalvy M, Tömböl Z, Farkas R, et al. Meta-analysis of adrenocortical tumour genomics data: novel pathogenic pathways revealed. Oncogene. 2010;29:3163-72 pubmed publisher
    ..These pathways include novel, previously undescribed pathomechanisms of adrenocortical tumours, and associated gene products may serve as diagnostic markers of malignancy and therapeutic targets...
  42. Tauchmanova L, Colao A, Marzano L, Sparano L, Camera L, Rossi A, et al. Andrenocortical carcinomas: twelve-year prospective experience. World J Surg. 2004;28:896-903 pubmed
    ..In conclusion, curative surgery was the most effective treatment. Monitoring arterial pressure, endocrine parameters, and metabolic parameters can be helpful for the early detection of AC recurrences...
  43. Sun B, Huang Q, Liu S, Chen M, Hawks C, Wang L, et al. Progressive loss of malignant behavior in telomerase-negative tumorigenic adrenocortical cells and restoration of tumorigenicity by human telomerase reverse transcriptase. Cancer Res. 2004;64:6144-51 pubmed
  44. Koschker A, Fassnacht M, Hahner S, Weismann D, Allolio B. Adrenocortical carcinoma -- improving patient care by establishing new structures. Exp Clin Endocrinol Diabetes. 2006;114:45-51 pubmed
    ..Adrenocortical carcinoma (ACC) is a rare and highly malignant tumour with a poor prognosis. Patients present with signs of steroid hormone excess (e.g., Cushing's syndrome) or symptoms due to an abdominal mass...
  45. Young W. Primary aldosteronism: renaissance of a syndrome. Clin Endocrinol (Oxf). 2007;66:607-18 pubmed
    ..In bilateral adrenal forms of primary aldosteronism, unilateral or bilateral adrenalectomy seldom corrects the hypertension and they should be treated medically with a mineralocorticoid receptor antagonist...
  46. Schteingart D. Adjuvant mitotane therapy of adrenal cancer - use and controversy. N Engl J Med. 2007;356:2415-8 pubmed
  47. Terzolo M, Reimondo G, Angeli A. Definition of an optimal strategy to evaluate and follow-up adrenal incidentalomas: time for further research. Eur J Endocrinol. 2009;161:529-32 pubmed publisher
    ..To add further to the argument of discussion, we also outline a clinically-oriented strategy for follow-up. In conclusion, the need for further research appears evident to define more efficient guidelines...
  48. Soon P, Libe R, Benn D, Gill A, Shaw J, Sywak M, et al. Loss of heterozygosity of 17p13, with possible involvement of ACADVL and ALOX15B, in the pathogenesis of adrenocortical tumors. Ann Surg. 2008;247:157-64 pubmed
  49. Tadjine M, Lampron A, Ouadi L, Horvath A, Stratakis C, Bourdeau I. Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). Clin Endocrinol (Oxf). 2008;69:367-73 pubmed publisher
    ..We hypothesized that adrenocortical adenomas that form in the context of PPNAD may harbour beta-catenin mutations...
  50. de Reynies A, Assie G, Rickman D, Tissier F, Groussin L, Rene Corail F, et al. Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival. J Clin Oncol. 2009;27:1108-15 pubmed publisher
    ..Adrenocortical tumors, especially cancers, remain challenging both for their diagnosis and prognosis assessment. The aim of this article is to identify molecular predictors of malignancy and of survival...
  51. Onoda N, Ishikawa T, Nishio K, Tahara H, Inaba M, Wakasa K, et al. Cushing's syndrome by left adrenocortical adenoma synchronously associated with primary aldosteronism by right adrenocortical adenoma: report of a case. Endocr J. 2009;56:495-502 pubmed
    ..We reviewed the cases reported, and discussed the significance of the minute nodules in the adrenal cortex, often found in association with the adrenocortical adenoma...
  52. Porpiglia F, Fiori C, Tarabuzzi R, Giraudo G, Garrone C, Morino M, et al. Is laparoscopic adrenalectomy feasible for adrenocortical carcinoma or metastasis?. BJU Int. 2004;94:1026-9 pubmed
    ..To review our experience with laparoscopic adrenalectomy (LA), to evaluate the effectiveness and safety of this procedure in patients with adrenal malignancy...
  53. Volante M, Bollito E, Sperone P, Tavaglione V, Daffara F, Porpiglia F, et al. Clinicopathological study of a series of 92 adrenocortical carcinomas: from a proposal of simplified diagnostic algorithm to prognostic stratification. Histopathology. 2009;55:535-43 pubmed publisher
    ..The aim was to investigate the impact of individual pathological parameters in the diagnosis and prognosis of adrenocortical carcinoma...