appendiceal neoplasms

Summary

Summary: Tumors or cancer of the APPENDIX.

Top Publications

  1. Smeenk R, van Velthuysen M, Verwaal V, Zoetmulder F. Appendiceal neoplasms and pseudomyxoma peritonei: a population based study. Eur J Surg Oncol. 2008;34:196-201 pubmed
    ..However it is not known exactly how often these neoplasms lead to PMP. The aim of this study is to investigate the incidence of both lesions and their relation...
  2. Panarelli N, Yantiss R. Mucinous neoplasms of the appendix and peritoneum. Arch Pathol Lab Med. 2011;135:1261-8 pubmed publisher
    ..As a result, appendiceal mucinous neoplasms and associated peritoneal disease represents one of the most confusing and controversial areas in gastrointestinal pathology...
  3. Mullen J, Savarese D. Carcinoid tumors of the appendix: a population-based study. J Surg Oncol. 2011;104:41-4 pubmed publisher
    ..Carcinoid tumors of the appendix are rare, and as such there are few data guiding their optimal treatment...
  4. Toumpanakis C, Standish R, Baishnab E, Winslet M, Caplin M. Goblet cell carcinoid tumors (adenocarcinoid) of the appendix. Dis Colon Rectum. 2007;50:315-22 pubmed
    ..We present the long-term results of a series of 15 patients, focusing on clinical manifestations, diagnosis, and management...
  5. Yantiss R, Shia J, Klimstra D, Hahn H, Odze R, Misdraji J. Prognostic significance of localized extra-appendiceal mucin deposition in appendiceal mucinous neoplasms. Am J Surg Pathol. 2009;33:248-55 pubmed publisher
  6. Gupta S, Parsa V, Adsay V, Heilbrun L, Smith D, Shields A, et al. Clinicopathological analysis of primary epithelial appendiceal neoplasms. Med Oncol. 2010;27:1073-8 pubmed publisher
    ..Three distinct histopathological disease entities exist in appendiceal tumors. The prognosis and management of these tumors should be based on the extent of disease and pathologic diagnosis...
  7. Mastoraki A, Papanikolaou I, Kanakis D, Safioleas P, Sakorafas G, Safioleas M. A case of signet ring carcinoma of the appendix: dilemmas in differential diagnosis and management. J Gastrointest Cancer. 2010;41:141-4 pubmed publisher
    ..Signet ring carcinoma (SRC) of the appendix consists one of the most biologically virulent cancers. We present the case of a patient with primary SRC complicated by the development of acute inflammation of the appendix...
  8. Cashin P, Nygren P, Hellman P, Granberg D, Andréasson H, Mahteme H. Appendiceal adenocarcinoids with peritoneal carcinomatosis treated with cytoreductive surgery and intraperitoneal chemotherapy: a retrospective study of in vitro drug sensitivity and survival. Clin Colorectal Cancer. 2011;10:108-12 pubmed publisher
  9. Plockinger U, Couvelard A, Falconi M, Sundin A, Salazar R, Christ E, et al. Consensus guidelines for the management of patients with digestive neuroendocrine tumours: well-differentiated tumour/carcinoma of the appendix and goblet cell carcinoma. Neuroendocrinology. 2008;87:20-30 pubmed

More Information

Publications62

  1. Khan M, Moran B. Four percent of patients undergoing colorectal cancer surgery may have synchronous appendiceal neoplasia. Dis Colon Rectum. 2007;50:1856-9 pubmed
    ..A special interest of the senior author in appendiceal and rectal cancer has prompted routine removal of the appendix in all cases undergoing surgery for colorectal cancer...
  2. Shapiro R, Eldar S, Sadot E, Papa M, Zippel D. Appendiceal carcinoid at a large tertiary center: pathologic findings and long-term follow-up evaluation. Am J Surg. 2011;201:805-8 pubmed publisher
    ..Nonetheless; it is an exceedingly rare diagnosis; found in only about .3% to .9% of appendectomy specimens. We report the clinical and pathologic characteristics of carcinoids found with long-term follow-up evaluation...
  3. Rindi G, Kloppel G, Couvelard A, Komminoth P, Korner M, Lopes J, et al. TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch. 2007;451:757-62 pubmed
    ..These proposals need to be validated and are meant to help clinicians in the stratification, treatment and follow-up of patients...
  4. Zauber P, Berman E, Marotta S, Sabbath Solitare M, Bishop T. Ki-ras gene mutations are invariably present in low-grade mucinous tumors of the vermiform appendix. Scand J Gastroenterol. 2011;46:869-74 pubmed publisher
    ..We assessed several molecular genetic changes, including Ki-ras gene mutations, in a large series of low-grade mucinous tumors of the appendix...
  5. Jiang Y, Long H, Wang W, Liu H, Tang Y, Zhang X. Clinicopathological features and immunoexpression profiles of goblet cell carcinoid and typical carcinoid of the appendix. Pathol Oncol Res. 2011;17:127-32 pubmed publisher
    ..Therefore, the term "low grade adenocarcinoma with neuroendocrine differentiation" might be more appropriate for GCC...
  6. Tang L, Shia J, Soslow R, Dhall D, Wong W, O Reilly E, et al. Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol. 2008;32:1429-43 pubmed publisher
    ..Surgical management with right hemicolectomy is recommended after appendectomy for most cases, particularly those with an adenocarcinoma component (groups B and C)...
  7. Haase E, Yoo D, Sugarbaker P. Management of appendiceal pseudomyxoma peritonei diagnosed during pregnancy. World J Surg Oncol. 2009;7:48 pubmed publisher
    ..Epithelial tumors of the appendix on the other hand are rare and account for only approximately 1% of all colorectal neoplasms; the occurrence of this neoplasm during pregnancy is extremely rare...
  8. Paredes Esteban R, Martínez de Vitoria J, Garcia Ruiz M. [An association of mucocele and carcinoid tumour of the appendix]. Cir Pediatr. 2006;19:250-2 pubmed
    ..The appendicectomy itself was curative, deeming it the appropiated treatment in tumours under 2 cm diameter...
  9. Gustafsson B, Siddique L, Chan A, Dong M, Drozdov I, Kidd M, et al. Uncommon cancers of the small intestine, appendix and colon: an analysis of SEER 1973-2004, and current diagnosis and therapy. Int J Oncol. 2008;33:1121-31 pubmed
    ..We present an overview of the epidemiology of these uncommon cancers, and address their clinical behavior, and current diagnostic and therapeutic options...
  10. Ko Y, Jung C, Oh S, Kim T, Won H, Kang J, et al. Primary signet ring cell carcinoma of the appendix: a rare case report and our 18-year experience. World J Gastroenterol. 2008;14:5763-8 pubmed
    ..She then received palliative systemic chemotherapy with 12 cycles of oxaliplatin, 5-flurorouracil, and leucovorin (FOLFOX-4). The patient currently is well without progression of disease 12 mo after beginning chemotherapy...
  11. Baratti D, Kusamura S, Nonaka D, Langer M, Andreola S, Favaro M, et al. Pseudomyxoma peritonei: clinical pathological and biological prognostic factors in patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). Ann Surg Oncol. 2008;15:526-34 pubmed
    ..We reviewed our 10-year monoinstitutional case series to identify selection factors predicting postoperative outcome...
  12. Lambert L, Armstrong T, Lee J, Liu S, Katz M, Eng C, et al. Incidence, risk factors, and impact of severe neutropenia after hyperthermic intraperitoneal mitomycin C. Ann Surg Oncol. 2009;16:2181-7 pubmed publisher
    ..This study analyzes the incidence and risk factors for developing neutropenia following MMC-HIPEC combined with CRS...
  13. Sugarbaker P. Epithelial appendiceal neoplasms. Cancer J. 2009;15:225-35 pubmed publisher
    ..The presence versus absence of lymph nodal metastases on survival have minimal significance (P = 0.0495). These results of treatment can be achieved with a 19% incidence of severe complications and a 2% mortality...
  14. Behranwala K, Agarwal T, El Sharkawi D, Shorvon D, Chang A. Laparoscopic resection of mucinous cystadenoma of appendix: a careful decision. Surg Laparosc Endosc Percutan Tech. 2006;16:347-8 pubmed
    ..Rupture of the lesion causes pseudomyxoma peritonei. We present a case to highlight this point and especially deplore the use of laparoscopy if the tumor clearly extends beyond the appendix...
  15. Salemis N, Gourgiotis S, Pinialidis D, Sambaziotist D. Primary mucinous cystadenocarcinoma of the appendix: an unusual presentation of a rare tumor. J Dig Dis. 2008;9:175-7 pubmed
  16. Mesina C, Vasile I, Vilcea I, Pasalega M, Calotă F, Enache D, et al. Carcinoid tumour of the appendix: problems of diagnosis and treatment. Chirurgia (Bucur). 2011;106:239-45 pubmed
    ..Controversy exists over the management following appendicectomy, especially with regard to the role of right hemicolectomy in patients with tumours smaller than 2 cm in diameter...
  17. Mantziari S, Grass F, Demartines N, Schaefer M. [Epithelial neoplasia of the appendix: what has recently changed?]. Rev Med Suisse. 2011;7:1362-5 pubmed
    ..Mucinous neoplasias possess the characteristic of extensive mucin production with intraperitoneal spread. Treatment options are ranging from right hemicolectomy to multivisceral resection with intraperitoneal chemotherapy...
  18. Austin F, Mavanur A, Sathaiah M, Steel J, Lenzner D, Ramalingam L, et al. Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms. Ann Surg Oncol. 2012;19:1386-93 pubmed publisher
    Peritoneal carcinomatosis (PC) in the setting of mucinous appendiceal neoplasms is characterized by the intraperitoneal accumulation of mucinous ascites and mucin-secreting epithelial cells that leads to progressive compression of intra-..
  19. Orta L, Trindade A, Luo J, Harpaz N. Appendiceal mucinous cystadenoma is a neoplastic complication of IBD: case-control study of primary appendiceal neoplasms. Inflamm Bowel Dis. 2009;15:415-21 pubmed publisher
    ..IBD is a risk factor for development of colorectal neoplasia. Although IBD frequently involves the appendix microscopically, it is uncertain whether it also predisposes to appendiceal neoplasia...
  20. Sugarbaker P, Bijelic L. The porta hepatis as a site of recurrence of mucinous appendiceal neoplasms treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy. Tumori. 2008;94:694-700 pubmed
    ..The goal of this study was to investigate the porta hepatis as a site of recurrence of appendiceal mucinous neoplasms...
  21. Pitiakoudis M, Kirmanidis M, Tsaroucha A, Christianakis E, Filippou D, Sivridis E, et al. Carcinoid tumor of the appendix during pregnancy. A rare case and a review of the literature. J BUON. 2008;13:271-5 pubmed
    ..Open appendectomy was carried out and at the histological examination carcinoid was found in the surgical specimen. Only few similar cases were found in the literature reporting appendiceal carcinoid tumor during pregnancy...
  22. Stewart J, Shen P, Russell G, Fenstermaker J, McWilliams L, Coldrun F, et al. A phase I trial of oxaliplatin for intraperitoneal hyperthermic chemoperfusion for the treatment of peritoneal surface dissemination from colorectal and appendiceal cancers. Ann Surg Oncol. 2008;15:2137-45 pubmed publisher
    ..Therefore, we undertook a phase I evaluation of IPHC with oxaliplatin for peritoneal dissemination from colorectal and appendiceal cancers to establish the dose-limiting toxicity (DLT) and the maximum tolerated dose (MTD)...
  23. Gilboa Y, Fridman E, Ofir K, Achiron R. Carcinoid tumor of the appendix: ultrasound findings in early pregnancy. Ultrasound Obstet Gynecol. 2008;31:576-8 pubmed publisher
    ..This is the first description of the transvaginal ultrasound features of a carcinoid tumor of the appendix...
  24. Fornaro R, Frascio M, Sticchi C, De Salvo L, Stabilini C, Mandolfino F, et al. Appendectomy or right hemicolectomy in the treatment of appendiceal carcinoid tumors?. Tumori. 2007;93:587-90 pubmed
    ..The aim of this work was to explicate the current therapeutic knowledge and to review the criteria for the indications of appendectomy or hemicolectomy...
  25. Low R, Barone R, Gurney J, Muller W. Mucinous appendiceal neoplasms: preoperative MR staging and classification compared with surgical and histopathologic findings. AJR Am J Roentgenol. 2008;190:656-65 pubmed publisher
    ..objective of our study was to determine the accuracy of MRI in the preoperative staging and classification of mucinous appendiceal neoplasms and to describe the MRI features that are useful for selecting patients for surgical resection.
  26. Alsaad K, Serra S, Schmitt A, Perren A, Chetty R. Cytokeratins 7 and 20 immunoexpression profile in goblet cell and classical carcinoids of appendix. Endocr Pathol. 2007;18:16-22 pubmed
    ..Goblet cell carcinoid should be regarded as a crypt cell or an amphicrine carcinoma rather than a variant of carcinoid tumor, a lesion that has benign connotations...
  27. Marte A, Sabatino M, Cautiero P, Accardo M, Romano M, Parmeggiani P. Unexpected finding of laparoscopic appendectomy: appendix MALT lymphoma in children. Pediatr Surg Int. 2008;24:471-3 pubmed
    ..According to our experience, low-grade MALToma can be managed by simple appendectomy. The histological examination should be the rule whenever an appendectomy is performed in children...
  28. Misdraji J. Appendiceal mucinous neoplasms: controversial issues. Arch Pathol Lab Med. 2010;134:864-70 pubmed publisher
    ..Finally, the controversy about the most effective treatment of patients with pseudomyxoma peritonei is discussed...
  29. Jiang Y, Long H, Li T, Wang W, Liu H, Zhang X. Schistosomiasis may contribute to goblet cell carcinoid of the appendix. J Parasitol. 2012;98:565-8 pubmed publisher
  30. Thompson R, Hawe M. A rare pathological trinity: an appendiceal ectopic pregnancy, acute appendicitis and a carcinoid tumour. Ir J Med Sci. 2011;180:579-80 pubmed publisher
    ..We present a case of a 27-year-old woman who was found to have an appendiceal ectopic pregnancy, a carcinoid tumour of the appendix and acute appendicitis existing concurrently. This triad of pathology has never been reported previously...
  31. Pai R, Beck A, Norton J, Longacre T. Appendiceal mucinous neoplasms: clinicopathologic study of 116 cases with analysis of factors predicting recurrence. Am J Surg Pathol. 2009;33:1425-39 pubmed publisher
    ..Nine patients with appendiceal neoplasms with invasion or high-grade cytology and follow-up showed 1-year, 3-year, and 5-year overall survival ..
  32. Chua T, Moran B, Sugarbaker P, Levine E, Glehen O, Gilly F, et al. Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. J Clin Oncol. 2012;30:2449-56 pubmed publisher
    ..The purpose of our study was to evaluate outcome and long-term survival after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) consolidated through an international registry study...
  33. Chua T, Chong C, Liauw W, Zhao J, Morris D. Inflammatory markers in blood and serum tumor markers predict survival in patients with epithelial appendiceal neoplasms undergoing surgical cytoreduction and intraperitoneal chemotherapy. Ann Surg. 2012;256:342-9 pubmed publisher
    ..The study examines the role inflammatory and tumor markers as biomarkers to preoperatively predict outcome in patients with epithelial appendiceal neoplasm undergoing cytoreduction and intraperitoneal chemotherapy...
  34. McQuellon R, Russell G, Shen P, Stewart J, Saunders W, Levine E. Survival and health outcomes after cytoreductive surgery with intraperitoneal hyperthermic chemotherapy for disseminated peritoneal cancer of appendiceal origin. Ann Surg Oncol. 2008;15:125-33 pubmed
    ..This aggressive therapy may impair patient quality of life (QOL). The purpose of this study was to monitor health outcomes before and after treatment...
  35. O Donnell M, Badger S, Beattie G, Carson J, Garstin W. Malignant neoplasms of the appendix. Int J Colorectal Dis. 2007;22:1239-48 pubmed
    b>Appendiceal neoplasms, first described in 1882, are still rare, with pre-operative diagnosis invariably difficult...
  36. Persaud T, Swan N, Torreggiani W. Giant mucinous cystadenoma of the appendix. Radiographics. 2007;27:553-7 pubmed
  37. Tchana Sato V, Detry O, Polus M, Thiry A, Detroz B, Maweja S, et al. Carcinoid tumor of the appendix: a consecutive series from 1237 appendectomies. World J Gastroenterol. 2006;12:6699-701 pubmed
    ..To report the experience of the CHU Sart Tilman, University of Liege, Belgium, in the management of appendiceal carinoid tumor...
  38. In t Hof K, van der Wal H, Kazemier G, Lange J. Carcinoid tumour of the appendix: an analysis of 1,485 consecutive emergency appendectomies. J Gastrointest Surg. 2008;12:1436-8 pubmed publisher
    ..The aim of this study is to conduct a retrospective analysis of the incidence and long-term results of carcinoid tumours of the appendix in emergency appendectomies...
  39. Gallo J, Martínez Ossa R, Ferrer G, Camara M. Mucinous appendicular cystadenocarcinoma and pregnancy. Am J Perinatol. 2001;18:155-7 pubmed
    ..Given the exceptionally low incidence tumors co-existing with pregnancy, we recommend a careful and complete appendix examination during cesarean and postpartum sterilization, and subsequent removal of tumors should they exist...
  40. Pham T, Wolff B, Abraham S, Drelichman E. Surgical and chemotherapy treatment outcomes of goblet cell carcinoid: a tertiary cancer center experience. Ann Surg Oncol. 2006;13:370-6 pubmed
    ..Goblet cell carcinoid (GCC) is a rare malignant tumor with distinct histological and clinical features. Our goals were to review the surgical and chemotherapy outcomes of patients with GCC...
  41. Park I, Yu C, Kim H, Kim J. [Clinical features and prognostic factors in primary adenocarcinoma of the appendix]. Korean J Gastroenterol. 2004;43:29-34 pubmed
    ..Primary appendiceal adenocarcinoma is a rare neoplasm that constitutes less than 0.5% of all gastrointestinal neoplasm. The aim of this study was to figure out its clinicopathologic characteristics that are not well understood...
  42. Zagrodnik D, Rose D. Mucinous cystadenoma of the appendix: diagnosis, surgical management, and follow-up. Curr Surg. 2003;60:341-3 pubmed
    ..To review the diagnostic examination and clinical presentation of mucinous cystadenoma of the appendix...
  43. Szych C, Staebler A, Connolly D, Wu R, Cho K, Ronnett B. Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma peritonei in women. Am J Pathol. 1999;154:1849-55 pubmed
    ..Our findings strongly support the conclusion that mucinous tumors involving the appendix and ovaries in women with PMP are clonal and derived from a single site, most likely the appendix...
  44. Kanthan R, Saxena A, Kanthan S. Goblet cell carcinoids of the appendix: immunophenotype and ultrastructural study. Arch Pathol Lab Med. 2001;125:386-90 pubmed
    ..Goblet cell carcinoids of the appendix are rare neoplasms with uncertain biological behavior...
  45. Pitiakoudis M, Argyropoulou P, Tsaroucha A, Prassopoulos P, Simopoulos C. Cystadenocarcinoma of the appendix: an incidental imaging finding in a patient with adenocarcinomas of the ascending and the sigmoid colon. BMC Gastroenterol. 2003;3:30 pubmed
    ..Primary adenocarcinomas of the appendix are uncommon. Mucoceles that result from mucinous adenocarcinomas of the appendix may be incidentally detected on imaging...
  46. Stancu M, Wu T, Wallace C, Houlihan P, Hamilton S, Rashid A. Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors. Mod Pathol. 2003;16:1189-98 pubmed
    ..These findings suggest that allelic loss of chromosomes 11q, 16q, and 18q in goblet cell carcinoids and ileal carcinoids may have an important role in the pathogenesis of these tumors...
  47. Parsons J, Freeswick P, Jarrett T. Appendiceal cystadenoma mimicking a cystic renal mass. Urology. 2004;63:981-2 pubmed
    ..This case demonstrates that mucinous cystadenomas arising from retroperitoneal structures might mimic renal neoplasms and should be considered in the differential diagnosis of cystic renal masses...
  48. Carmignani C, Hampton R, Sugarbaker C, Chang D, Sugarbaker P. Utility of CEA and CA 19-9 tumor markers in diagnosis and prognostic assessment of mucinous epithelial cancers of the appendix. J Surg Oncol. 2004;87:162-6 pubmed
    ..The use of these tumor markers in mucinous epithelial tumors of the appendix has not been previously determined...
  49. Beyrouti M, Gharbi A, Abid M, Beyrouti R, Elleuch S, Gharbi W, et al. [Carcinoid tumors of the appendix. A report of 46 cases]. Tunis Med. 2004;82:668-73 pubmed
    ..There is no reported case of lymph node or systemic metastasis. The authors discuss data in the literature and analyse the features of the clinical picture, diagnosis, and try to define a convenient attitude of treatment of these tumors...
  50. Iwuagwu O, Jameel J, Drew P, Hartley J, Monson J. Primary carcinoma of the appendix - Hull series. Dig Surg. 2005;22:163-7 pubmed
    ..Once the diagnosis of AC is made, patients are treated by various strategies including surgery, chemotherapy depending on nodal status of the disease...
  51. Sugarbaker P, Alderman R, Edwards G, Marquardt C, Gushchin V, Esquivel J, et al. Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy. Ann Surg Oncol. 2006;13:635-44 pubmed
    ..Patients with these diagnoses were treated by cytoreductive surgery and perioperative intraperitoneal chemotherapy...
  52. Murphy E, Farquharson S, Moran B. Management of an unexpected appendiceal neoplasm. Br J Surg. 2006;93:783-92 pubmed
    b>Appendiceal neoplasms are rare and most present unexpectedly as acute appendicitis. The classification and management are confusing, and there are few substantial reports in the literature.
  53. Bamboat Z, Berger D. Is right hemicolectomy for 2.0-cm appendiceal carcinoids justified?. Arch Surg. 2006;141:349-52; discussion 352 pubmed
    ..We believe right hemicolectomy (RHC) is not necessary in patients with an appendiceal carcinoid greater than 2.0 cm...