intestinal neoplasms

Summary

Summary: Tumors or cancer of the INTESTINES.

Top Publications

  1. Vermeulen L, Morrissey E, van der Heijden M, Nicholson A, Sottoriva A, Buczacki S, et al. Defining stem cell dynamics in models of intestinal tumor initiation. Science. 2013;342:995-8 pubmed publisher
    ..Our work confirms the previously theoretical notion that the tissue architecture of the intestine suppresses the accumulation of mutated lineages. ..
  2. Banck M, Kanwar R, Kulkarni A, Boora G, Metge F, Kipp B, et al. The genomic landscape of small intestine neuroendocrine tumors. J Clin Invest. 2013;123:2502-8 pubmed publisher
    ..We conclude that sequencing-based analysis may provide provisional grouping of SI-NETs by therapeutic targets or deregulated pathways...
  3. Grimm C, Chavez L, Vilardell M, Farrall A, Tierling S, Böhm J, et al. DNA-methylome analysis of mouse intestinal adenoma identifies a tumour-specific signature that is partly conserved in human colon cancer. PLoS Genet. 2013;9:e1003250 pubmed publisher
  4. Lee H, Lee O, Jang K, Bae Y, Chung J, Eom D, et al. Combined loss of E-cadherin and aberrant ?-catenin protein expression correlates with a poor prognosis for small intestinal adenocarcinomas. Am J Clin Pathol. 2013;139:167-76 pubmed publisher
  5. Li S, Martijn C, Cui T, Essaghir A, Luque R, Demoulin J, et al. The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells. PLoS ONE. 2012;7:e48411 pubmed publisher
    ..Thus, six novel genes may regulate cell growth and differentiation in normal and tumour neuroendocrine cells and have a role in a novel octreotide mechanism system...
  6. Schepers A, Snippert H, Stange D, van den Born M, van Es J, van de Wetering M, et al. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science. 2012;337:730-5 pubmed publisher
    ..The Lgr5(+) cells are intermingled with Paneth cells near the adenoma base, a pattern reminiscent of the architecture of the normal crypt niche...
  7. Kopec A, Thompson C, Kim S, Forgacs A, Zacharewski T. Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia. Toxicol Appl Pharmacol. 2012;262:124-38 pubmed publisher
    ..These qualitative and quantitative differences in differential gene expression, which correlate with differences in tissue dose, likely contribute to the disparate intestinal tumor outcomes...
  8. Masselli G, Colaiacomo M, Marcelli G, Bertini L, Casciani E, Laghi F, et al. MRI of the small-bowel: how to differentiate primary neoplasms and mimickers. Br J Radiol. 2012;85:824-37 pubmed publisher
    ..In this paper, MRI features of primary small-bowel neoplasms, the most important signs for differential diagnosis and the diseases that can be considered as mimickers of small-bowel neoplasms, are discussed...
  9. Amos Landgraf J, Irving A, Hartman C, Hunter A, Laube B, Chen X, et al. Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms. Proc Natl Acad Sci U S A. 2012;109:2060-5 pubmed publisher
    ..Another class of tumors exhibits highly biased monoallelic expression of the mutant Apc allele, providing evidence for a stochastic or random process of monoallelic epigenetic silencing of the tumor suppressor gene Apc...

More Information

Publications62

  1. Barker N, Ridgway R, van Es J, van de Wetering M, Begthel H, van den Born M, et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457:608-11 pubmed publisher
    ..Even after 30weeks, large adenomas are very rare in these mice. We conclude that stem-cell-specific loss of Apc results in progressively growing neoplasia...
  2. Turan M, Karadayi K, Duman M, Ozer H, Arici S, Yildirir C, et al. Small bowel tumors in emergency surgery. Ulus Travma Acil Cerrahi Derg. 2010;16:327-33 pubmed
    ..The aim of the present study was to describe the clinical presentation, diagnostic work-up, surgical therapy, and prognosis of 13 patients with small bowel tumor admitted for surgical procedures in an emergency setting...
  3. Ellender M, Harrison J, Meijne E, Huiskamp R, Kozlowski R, Haines J, et al. Intestinal tumours induced in Apc(Min/+) mice by X-rays and neutrons. Int J Radiat Biol. 2011;87:385-99 pubmed publisher
    ..To compare the development of intestinal adenomas following neutron and X-ray exposure of Apc(Min/+) mice (Apc - adenomatous polyposis coli; Min - multiple intestinal neoplasia)...
  4. Masselli G, Polettini E, Casciani E, Bertini L, Vecchioli A, Gualdi G. Small-bowel neoplasms: prospective evaluation of MR enteroclysis. Radiology. 2009;251:743-50 pubmed publisher
  5. Järhult J, Landerholm K, Falkmer S, Nordenskjold M, Sundler F, Wierup N. First report on metastasizing small bowel carcinoids in first-degree relatives in three generations. Neuroendocrinology. 2010;91:318-23 pubmed publisher
    ..The aim of this study was to describe the clinical characteristics as well as the histopathological, immunohistochemical (IHC) and genetic data of metastasizing ileal carcinoids in three consecutive first-degree relatives...
  6. Halfdanarson T, McWilliams R, Donohue J, Quevedo J. A single-institution experience with 491 cases of small bowel adenocarcinoma. Am J Surg. 2010;199:797-803 pubmed publisher
    ..The optimal treatment of small bowel adenocarcinoma is unknown...
  7. Boudreaux J, Klimstra D, Hassan M, Woltering E, Jensen R, Goldsmith S, et al. The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: well-differentiated neuroendocrine tumors of the Jejunum, Ileum, Appendix, and Cecum. Pancreas. 2010;39:753-66 pubmed publisher
    ..Further studies of novel approaches such as peptide receptor radiotherapy are also warranted...
  8. Jann H, Roll S, Couvelard A, Hentic O, Pavel M, Müller Nordhorn J, et al. Neuroendocrine tumors of midgut and hindgut origin: tumor-node-metastasis classification determines clinical outcome. Cancer. 2011;117:3332-41 pubmed publisher
    ..The purpose of this study was to test the efficacy of a proposal for TNM staging and grading for midgut and hindgut NETs...
  9. Haan J, Buffart T, Eijk P, van de Wiel M, Van Wieringen W, Howdle P, et al. Small bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers. Ann Oncol. 2012;23:367-74 pubmed publisher
  10. Drozdov I, Svejda B, Gustafsson B, Mane S, Pfragner R, Kidd M, et al. Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia. PLoS ONE. 2011;6:e22457 pubmed publisher
  11. Cui T, Hurtig M, Elgue G, Li S, Veronesi G, Essaghir A, et al. Paraneoplastic antigen Ma2 autoantibodies as specific blood biomarkers for detection of early recurrence of small intestine neuroendocrine tumors. PLoS ONE. 2010;5:e16010 pubmed publisher
    ..Therefore, we evaluated whether Ma2 autoantibodies detection in the blood stream is useful for the clinical diagnosis and recurrence of SI-NETs...
  12. Rodrigo J, García Pedrero J, Llorente J, Fresno M, Allonca E, Suarez C, et al. Down-regulation of annexin A1 and A2 protein expression in intestinal-type sinonasal adenocarcinomas. Hum Pathol. 2011;42:88-94 pubmed publisher
    ..Annexin A2 expression is also reduced in intestinal-type sinonasal adenocarcinoma, and this loss of expression is associated to the more aggressive histopathological types...
  13. Faro A, Boj S, Clevers H. Fishing for intestinal cancer models: unraveling gastrointestinal homeostasis and tumorigenesis in zebrafish. Zebrafish. 2009;6:361-76 pubmed publisher
    ..An appealing avenue for cancer research in zebrafish is large-scale screens to identify chemotherapeutic and chemopreventive agents in conjunction with the in vivo imaging approaches that zebrafish affords...
  14. Kidd M, Drozdov I, Joseph R, Pfragner R, Culler M, Modlin I. Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines. Cancer. 2008;113:690-700 pubmed publisher
    ..Given the coexistence of somatostatin and dopamine regulatory receptors on NET cells, the antiproliferative efficacy as well as the signaling and transcriptional targets of their ligands were evaluated...
  15. Szczepura A, Price C, Gumber A. Breast and bowel cancer screening uptake patterns over 15 years for UK south Asian ethnic minority populations, corrected for differences in socio-demographic characteristics. BMC Public Health. 2008;8:346 pubmed publisher
    ..However, studies to date have not adjusted findings for differences in demographics and socio-economic status of these populations...
  16. Nicholl M, Ahuja V, Conway W, Vu V, Sim M, Singh G. Small bowel adenocarcinoma: understaged and undertreated?. Ann Surg Oncol. 2010;17:2728-32 pubmed publisher
    ..Surgery is the mainstay of therapy, but the extent of lymph node (LN) recovery necessary for optimal care of jejunoileal SBA is unknown...
  17. Kidd M, Modlin I. Small intestinal neuroendocrine cell pathobiology: 'carcinoid' tumors. Curr Opin Oncol. 2011;23:45-52 pubmed publisher
    ..Despite these issues, approximately 350 studies were published in the last year...
  18. Trani D, Datta K, Doiron K, Kallakury B, Fornace A. Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates. Radiat Environ Biophys. 2010;49:389-96 pubmed publisher
  19. Ashton G, Morton J, Myant K, Phesse T, Ridgway R, Marsh V, et al. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell. 2010;19:259-69 pubmed publisher
    ..Importantly, this work suggests that FAK inhibitors may suppress tumorigenesis in patients at high risk of developing colorectal cancer. ..
  20. Lee S, Hu L, Gonzalez Navajas J, Seo G, Shen C, Brick J, et al. ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med. 2010;16:665-70 pubmed publisher
    ..Our data reveal a new facet of oncogene-environment interaction, in which microflora-induced TLR activation regulates oncogene expression and related IEC tumor growth in a susceptible host...
  21. Fre S, Pallavi S, Huyghe M, Lae M, Janssen K, Robine S, et al. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A. 2009;106:6309-14 pubmed publisher
    ..Importantly, our experimental evidence raises the possibility that Notch activation might be an essential initial event triggering colorectal cancer...
  22. Hu D, Fang W, Han A, Gallagher L, Davis R, Xiong B, et al. c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis. 2008;29:2317-24 pubmed publisher
  23. Drozdov I, Kidd M, Nadler B, Camp R, Mane S, Hauso O, et al. Predicting neuroendocrine tumor (carcinoid) neoplasia using gene expression profiling and supervised machine learning. Cancer. 2009;115:1638-50 pubmed publisher
  24. Fang W, Han A, Bi X, Xiong B, Yang W. Tumor inhibition by sodium selenite is associated with activation of c-Jun NH2-terminal kinase 1 and suppression of beta-catenin signaling. Int J Cancer. 2010;127:32-42 pubmed publisher
    ..Taken together, our data demonstrate that sodium selenite inhibits intestinal carcinogenesis in vivo and in vitro through activating JNK1 and suppressing beta-catenin signaling, a novel anticancer mechanism of selenium...
  25. van Weyenberg S, Meijerink M, Jacobs M, van der Peet D, van Kuijk C, Mulder C, et al. MR enteroclysis in the diagnosis of small-bowel neoplasms. Radiology. 2010;254:765-73 pubmed publisher
  26. Leja J, Yu D, Nilsson B, Gedda L, Zieba A, Hakkarainen T, et al. Oncolytic adenovirus modified with somatostatin motifs for selective infection of neuroendocrine tumor cells. Gene Ther. 2011;18:1052-62 pubmed publisher
    ..We conclude that modification of adenovirus with the FWKT motif may be beneficial for NET therapy...
  27. Edfeldt K, Björklund P, Akerstrom G, Westin G, Hellman P, Stalberg P. Different gene expression profiles in metastasizing midgut carcinoid tumors. Endocr Relat Cancer. 2011;18:479-89 pubmed publisher
    ..This study reveals differences in gene expression profiles and novel genes that may be of importance in midgut carcinoid tumor progression...
  28. Velho S, Haigis K. Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras. Exp Cell Res. 2011;317:2732-9 pubmed publisher
    ..While the complexity of K-RAS biology has thus far prevented a comprehensive understanding of its oncogenic properties, the work to date lays a foundation for the development of new therapeutic strategies to treat K-RAS mutant CRC...
  29. Norlén O, Stalberg P, Oberg K, Eriksson J, Hedberg J, Hessman O, et al. Long-term results of surgery for small intestinal neuroendocrine tumors at a tertiary referral center. World J Surg. 2012;36:1419-31 pubmed publisher
    ..Our aim was to identify prognostic factors for survival and to evaluate outcome after surgery in SI-NET patients...
  30. Landry C, Brock G, Scoggins C, McMasters K, Martin R. A proposed staging system for small bowel carcinoid tumors based on an analysis of 6,380 patients. Am J Surg. 2008;196:896-903; discussion 903 pubmed publisher
    ..Little is known about the long-term prognosis of small bowel carcinoids because currently no staging system exists...
  31. Hsu K, Tsai H, Lin P, Hsu Y, Shan Y, Lu P. Osteopontin expression is an independent adverse prognostic factor in resectable gastrointestinal stromal tumor and its interaction with CD44 promotes tumor proliferation. Ann Surg Oncol. 2010;17:3043-52 pubmed publisher
    ..This study was designed to evaluate the clinicopathologic significance of OPN expression in patients with resectable GIST...
  32. O Connor P, Lapointe T, Beck P, Buret A. Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflamm Bowel Dis. 2010;16:1411-20 pubmed publisher
    ..The present review integrates clinical and basic research observations in an attempt to provide a comprehensive understanding of how inflammatory processes may contribute to intestinal cancer development in IBD patients...
  33. Bilimoria K, Bentrem D, Wayne J, Ko C, Bennett C, Talamonti M. Small bowel cancer in the United States: changes in epidemiology, treatment, and survival over the last 20 years. Ann Surg. 2009;249:63-71 pubmed publisher
    ..Previous studies have shown an increasing incidence of small bowel tumors in the United States. Our objective was to assess this increase by examining changes in histology-specific incidence, treatment, and survival...
  34. Koehler J, Harper W, Barnard M, Yusta B, Drucker D. Glucagon-like peptide-2 does not modify the growth or survival of murine or human intestinal tumor cells. Cancer Res. 2008;68:7897-904 pubmed publisher
  35. Jedlicka P, Gutierrez Hartmann A. Ets transcription factors in intestinal morphogenesis, homeostasis and disease. Histol Histopathol. 2008;23:1417-24 pubmed publisher
  36. Anzidei M, Napoli A, Zini C, Kirchin M, Catalano C, Passariello R. Malignant tumours of the small intestine: a review of histopathology, multidetector CT and MRI aspects. Br J Radiol. 2011;84:677-90 pubmed publisher
    ..The aim of this article is to review MDCT and MRI protocols for the evaluation of small bowel tumours and to provide a concise yet comprehensive guide to the most relevant imaging features relative to histopathology...
  37. Zaanan A, Gauthier M, Malka D, Locher C, Gornet J, Thirot Bidault A, et al. Second-line chemotherapy with fluorouracil, leucovorin, and irinotecan (FOLFIRI regimen) in patients with advanced small bowel adenocarcinoma after failure of first-line platinum-based chemotherapy: a multicenter AGEO study. Cancer. 2011;117:1422-8 pubmed publisher
    ..The aim of this study was to evaluate the efficacy and tolerability of fluorouracil, leucovorin, and irinotecan (FOLFIRI regimen) as second-line chemotherapy in patients with advanced SBA...
  38. Overman M, Kopetz S, Lin E, Abbruzzese J, Wolff R. Is there a role for adjuvant therapy in resected adenocarcinoma of the small intestine. Acta Oncol. 2010;49:474-9 pubmed publisher
    ..We undertook a retrospective analysis to evaluate the benefit of adjuvant therapy in a clearly defined patient population with curatively resected small bowel adenocarcinoma...
  39. Zouhairi M, Venner A, Charabaty A, Pishvaian M. Small bowel adenocarcinoma. Curr Treat Options Oncol. 2008;9:388-99 pubmed publisher
    ..Still, there remains great need for multi-institutional, cooperative group studies to define the optimal treatment of small bowel adenocarcinoma, both in the adjuvant and advanced/metastatic setting...
  40. Volate S, Muga S, Issa A, Nitcheva D, Smith T, Wargovich M. Epigenetic modulation of the retinoid X receptor alpha by green tea in the azoxymethane-Apc Min/+ mouse model of intestinal cancer. Mol Carcinog. 2009;48:920-33 pubmed publisher
    ..The results suggest that a low concentration of GT is sufficient to desilence RXR alpha and inhibit intestinal tumorigenesis in the Apc(Min/+) mouse...
  41. Drozdov I, Kidd M, Gustafsson B, Svejda B, Joseph R, Pfragner R, et al. Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. Cancer. 2009;115:4934-45 pubmed publisher
    ..Given the expression of 5-HT receptors on NETs, the authors hypothesized that 5-HT autoregulated NET proliferation...
  42. Rinke A, Muller H, Schade Brittinger C, Klose K, Barth P, Wied M, et al. Placebo-controlled, double-blind, prospective, randomized study on the effect of octreotide LAR in the control of tumor growth in patients with metastatic neuroendocrine midgut tumors: a report from the PROMID Study Group. J Clin Oncol. 2009;27:4656-63 pubmed publisher
    ..We performed a placebo-controlled, double-blind, phase IIIB study in patients with well-differentiated metastatic midgut NETs. The hypothesis was that octreotide LAR prolongs time to tumor progression and survival...
  43. Chandra S, Nolan M, Malarkey D. Chemical carcinogenesis of the gastrointestinal tract in rodents: an overview with emphasis on NTP carcinogenesis bioassays. Toxicol Pathol. 2010;38:188-97 pubmed publisher
    ..In conclusion, the most common induced GIT tumors are squamous neoplasms of the forestomach, glandular neoplasms of the stomach are rare, and rats appear more prone to developing LI (colorectal) cancer compared to mice...
  44. Trobridge P, Knoblaugh S, Washington M, Munoz N, Tsuchiya K, Rojas A, et al. TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. Gastroenterology. 2009;136:1680-8.e7 pubmed publisher
    ..The RAS-RAF-ERK pathway is frequently up-regulated in colon cancer via mutational activation of KRAS or BRAF. We assessed how these pathways interact in vivo and affect formation of colorectal tumors...
  45. Stern A. A quantitative assessment of the carcinogenicity of hexavalent chromium by the oral route and its relevance to human exposure. Environ Res. 2010;110:798-807 pubmed publisher
    ..The 2008 NTP chronic bioassay of sodium dichromate dihydrate in drinking water found clear evidence of carcinogenicity in rodents and allows a generalizable estimate of the human ingestion cancer potency of Cr(6+)...
  46. Masselli G, Gualdi G. Evaluation of small bowel tumors: MR enteroclysis. Abdom Imaging. 2010;35:23-30 pubmed publisher
  47. Overman M, Hu C, Wolff R, Chang G. Prognostic value of lymph node evaluation in small bowel adenocarcinoma: analysis of the surveillance, epidemiology, and end results database. Cancer. 2010;116:5374-82 pubmed publisher
    ..The objective of the current study was to evaluate the impact of the number of positive and negative lymph nodes on survival after curative resection...
  48. Kress E, Skah S, Sirakov M, Nadjar J, Gadot N, Scoazec J, et al. Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis. Gastroenterology. 2010;138:1863-74 pubmed publisher
    ..Because the WNT pathway is a major player in controlling intestinal homeostasis, we addressed whether the TRalpha1 receptor has tumor-inducing potential...
  49. Guillen Ahlers H, Suckow M, Castellino F, Ploplis V. Fas/CD95 deficiency in ApcMin/+ mice increases intestinal tumor burden. PLoS ONE. 2010;5:e9070 pubmed publisher
    ..Fas, a member of the tumor necrosis family, is responsible for initiating the apoptotic pathway when bound to its ligand, Fas-L. Defects in the Fas-mediated apoptotic pathway have been reported in colorectal cancer...
  50. Halberg R, Waggoner J, Rasmussen K, White A, Clipson L, Prunuske A, et al. Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res. 2009;69:5768-75 pubmed publisher
    ..Possible factors that promote invasion include age-dependent epigenetic changes, conservative somatic recombination, or direct effects of alleles in the F(1) hybrid genetic background...
  51. Yang S, Lin F, Tsai H, Lin C, Chin H, Wong J, et al. Alginate-folic acid-modified chitosan nanoparticles for photodynamic detection of intestinal neoplasms. Biomaterials. 2011;32:2174-82 pubmed publisher
    ..These studies demonstrate that the alginate incorporated and folic acid-conjugated chitosan nanoparticles are excellent vectors for colorectal-specific delivery of 5-ALA for fluorescent endoscopic detection...
  52. Bellutti M, Fry L, Schmitt J, Seemann M, Klose S, Malfertheiner P, et al. Detection of neuroendocrine tumors of the small bowel by double balloon enteroscopy. Dig Dis Sci. 2009;54:1050-8 pubmed publisher
    ..The objective of this study was to evaluate the use of double balloon enteroscopy (DBE) for the detection of the primary tumor in patients with NET...
  53. Wang D, Wang H, Ning W, Backlund M, Dey S, DuBois R. Loss of cannabinoid receptor 1 accelerates intestinal tumor growth. Cancer Res. 2008;68:6468-76 pubmed publisher
    ..These results indicate that the endogenous cannabinoid system may represent a potential therapeutic target for prevention or treatment of colorectal cancer...