experimental sarcoma

Summary

Summary: Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA.

Top Publications

  1. Kelleher D, Nauth C, Thews O, Krueger W, Vaupel P. Localized hypothermia: impact on oxygenation, microregional perfusion, metabolic and bioenergetic status of subcutaneous rat tumours. Br J Cancer. 1998;78:56-61 pubmed
    ..No changes in lactate or adenylate phosphate levels were observed. As a way of improving tumour oxygenation, localized hypothermia may therefore be a useful means of radiosensitization...
  2. Bremner J, Wood S, Bradley J, Griffiths J, Adams G, Brown S. 31P magnetic resonance spectroscopy as a predictor of efficacy in photodynamic therapy using differently charged zinc phthalocyanines. Br J Cancer. 1999;81:616-21 pubmed
    ..A parallel sequence was observed for the blood flow effects, demonstrating that reduction in blood flow is an important factor in PDT with these sensitizers...
  3. Shankaran V, Ikeda H, Bruce A, White J, Swanson P, Old L, et al. IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature. 2001;410:1107-11 pubmed
    ..However, this process also leads to the immunoselection of tumour cells that are more capable of surviving in an immunocompetent host, which explains the apparent paradox of tumour formation in immunologically intact individuals...
  4. Karnbach C, Daws M, Niemi E, Nakamura M. Immune rejection of a large sarcoma following cyclophosphamide and IL-12 treatment requires both NK and NK T cells and is associated with the induction of a novel NK T cell population. J Immunol. 2001;167:2569-76 pubmed
  5. Crowe N, Smyth M, Godfrey D. A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas. J Exp Med. 2002;196:119-27 pubmed
  6. Beebe S, White J, Blackmore P, Deng Y, Somers K, Schoenbach K. Diverse effects of nanosecond pulsed electric fields on cells and tissues. DNA Cell Biol. 2003;22:785-96 pubmed
    ..Potential applications for nsPEF include inducing apoptosis in cells and tumors, probing signal transduction mechanisms that determine cell fate, and enhancing gene expression...
  7. Charles K, Rivory L, Brown S, Liddle C, Clarke S, Robertson G. Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer. Clin Cancer Res. 2006;12:7492-7 pubmed
    ..We sought to examine this link by using an explant sarcoma in a novel transgenic mouse model of human CYP3A4 regulation...
  8. Chen B, Roskams T, de Witte P. Antivascular tumor eradication by hypericin-mediated photodynamic therapy. Photochem Photobiol. 2002;76:509-13 pubmed
    ..Our results strongly suggest that targeting the tumor vasculature by applying short drug-light interval PDT with hypericin might be a promising way to eradicate solid tumors...
  9. Al Sakere B, Bernat C, Andre F, Connault E, Opolon P, Davalos R, et al. A study of the immunological response to tumor ablation with irreversible electroporation. Technol Cancer Res Treat. 2007;6:301-6 pubmed
    ..We confirm here that immune response is not instrumental in irreversible electroporation efficacy, and we propose that irreversible electroporation may be, therefore, a treatment modality of interest to immunodepressed cancer patients...

More Information

Publications105 found, 100 shown here

  1. Vaupel P, Kelleher D, Engel T. Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour. Br J Cancer. 1994;69:46-9 pubmed
    ..Perfusion rate seems to play a paramount role in determining energy status only in low-flow tumours or low-flow tissue areas...
  2. Rychly J, Knippel E, Krygier Stojalowska A, Nizze H, Kuchnio M, Kraeft S. DNA cytometric and histologic findings in mouse tumors (BP and S 180) with different response to treatment with tumor necrosis factor. Acta Oncol. 1990;29:47-51 pubmed
    ..We concluded that cell infiltration may be of importance for tumor regression and that aneuploid cell populations are more sensitive to TNF treatment than eudiploid cells...
  3. Wood P, Hirst D. Cinnarizine and flunarizine as radiation sensitisers in two murine tumours. Br J Cancer. 1988;58:742-5 pubmed
    ..In a normal tissue study, 5 mg kg-1 flunarizine did not enhance the reduction in white cell counts produced by X-ray doses of 2-8 Gy. These data suggest that flunarizine may have some potential use as a radiosensitiser...
  4. Schaffer M, Schaffer P, Jori G, Corti L, Sotti G, Hofstetter A, et al. Radiation therapy combined with photofrin or 5-ALA: effect on Lewis sarcoma tumor lines implanted in mice. Preliminary results. Tumori. 2002;88:407-10 pubmed
    ..In the present study we investigated whether a porphyrin derivative that is currently used as a tumor-photosensitizing agent in photodynamic therapy (PDT) may also act as a tumor-specific radiosensitizer...
  5. Hirata A, Tsukamoto T, Yamamoto M, Takasu S, Sakai H, Ban H, et al. Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine. Oncol Rep. 2007;18:755-61 pubmed
    ..Our data add to the understanding of the carcinogenic susceptibility of p53 knockout mice, and may help to elucidate the pathogenesis of HS development...
  6. Tevz G, Kranjc S, Cemazar M, Kamensek U, Coer A, Krzan M, et al. Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy alone or in combination with ionizing radiation in murine sarcomas. J Gene Med. 2009;11:1125-37 pubmed publisher
    ..The present study demonstrates the feasibility of treatment by IL-12 gene electrotransfer combined with local tumor or lung metastases irradiation on sarcoma tumors for translation into the clinical setting. ..
  7. Nisancioglu M, Betsholtz C, Genove G. The absence of pericytes does not increase the sensitivity of tumor vasculature to vascular endothelial growth factor-A blockade. Cancer Res. 2010;70:5109-15 pubmed publisher
    ..Our observations suggest that additional targeting of pericytes does not increase the antitumor effect already generated by anti-VEGF drugs. ..
  8. Miyauchi M, Koshikawa N, Kowamura K, Fukushima T, Mochizuki S, Awaya A, et al. Augmentation with serum thymic factor of suppressive effects on retroviral tumor development in hosts immune to v-onc product. Leukemia. 1997;11 Suppl 3:213-5 pubmed
    ..All sera of animals that developed sarcomas were positive to P85 in Western blot analysis. These results showed that FTS augmented suppressive effects on sarcoma development in hosts immune to the viral oncogene product...
  9. Freire Garabal M, Núñez Iglesias M, Rey Mendez M, Pereiro Raposo M, Riveiro P, Fernández Rial J, et al. Effects of amphetamine on the development of Moloney sarcoma virus-induced tumors in mice. Oncol Rep. 1998;5:381-3 pubmed
    ..However, no effects of amphetamine on tumor development were observed when it was administered during the 3 days before tumor inoculation. ..
  10. Remedi M, DeMarchi M, Hliba E, Depiante Depaoli M. Effect of estrogen and antiestrogen therapy in rats bearing mesenchymal tumors. Tumour Biol. 1999;20:242-50 pubmed
    ..In summary, the antiestrogen treatment can have an antitumor effect in mesenchymal tumors, possibly by modifying the immunological status of the host. ..
  11. Sorensen D, Leirdal M, Iversen P, Sioud M. Combination of endostatin and a protein kinase Calpha DNA enzyme improves the survival of rats with malignant glioma. Neoplasia. 2002;4:474-9 pubmed
    ..0009) or endostatin (P<.025) alone. Thus, the combined treatment may represent an attractive therapeutic strategy against malignant gliomas. ..
  12. Kaufmann B, Muller S, Hanisch F, Hartmann U, Paulsson M, Maurer P, et al. Structural variability of BM-40/SPARC/osteonectin glycosylation: implications for collagen affinity. Glycobiology. 2004;14:609-19 pubmed
    ..BM-40 carrying high-mannose structures binds collagen I with higher affinity, suggesting that differentially glycosylated forms may have different functional roles in vivo. ..
  13. Thews O, Lambert C, Kelleher D, Biesalski H, Vaupel P, Frank J. Possible protective effects of alpha-tocopherol on enhanced induction of reactive oxygen species by 2-methoxyestradiol in tumors. Adv Exp Med Biol. 2005;566:349-55 pubmed
    ..Inhibition of SOD during ROS-generating hyperthermia results in pronounced cell injury and an improved local tumor control whereas exogenously applied vitamin E seems not to have an impact on oxidative stress. ..
  14. Mohamed F, Stuart O, Glehen O, Urano M, Sugarbaker P. Optimizing the factors which modify thermal enhancement of melphalan in a spontaneous murine tumor. Cancer Chemother Pharmacol. 2006;58:719-24 pubmed
    ..5 degrees C may optimize anti-neoplastic activity. These data may be useful in formulating clinical protocols in which melphalan and heat are combined. ..
  15. Stuben G, Stuschke M, Knühmann K, Horsman M, Sack H. The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: oxygenation and tumour control studies. Radiother Oncol. 1998;48:143-8 pubmed
    ..However, only one tumour showed a significant improvement after CON treatment, suggesting that not all hypoxic human tumours might benefit from this type of therapy. ..
  16. Kieber Emmons T, Luo P, Qiu J, Chang T, O I, Blaszczyk Thurin M, et al. Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses. Nat Biotechnol. 1999;17:660-5 pubmed
  17. Asai T, Nagatsuka M, Kuromi K, Yamakawa S, Kurohane K, Ogino K, et al. Suppression of tumor growth by novel peptides homing to tumor-derived new blood vessels. FEBS Lett. 2002;510:206-10 pubmed
    ..Taken together, ASSSYPLIHWRPWAR-peptide may cause tumor dormancy through inhibition of angiogenesis, and the WRP sequence may be the minimal and essential sequence for this activity. ..
  18. Thews O, Kelleher D, Vaupel P. Dynamics of tumor oxygenation and red blood cell flux in response to inspiratory hyperoxia combined with different levels of inspiratory hypercapnia. Radiother Oncol. 2002;62:77-85 pubmed
    ..Since no principal differences in oxygenation and perfusion were seen between the gases containing 2.5 and 5% CO2, the former may be preferable for inspiratory hyperoxia. ..
  19. Haynes N, Trapani J, Teng M, Jackson J, Cerruti L, Jane S, et al. Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors. Blood. 2002;100:3155-63 pubmed
    ..Our study has illustrated the practical advantage of engineering a T-cell signaling complex that codelivers CD28 activation, dependent only upon the tumor's expression of the appropriate tumor associated antigen. ..
  20. Steinman H, Burstein E, Lengner C, Gosselin J, Pihan G, Duckett C, et al. An alternative splice form of Mdm2 induces p53-independent cell growth and tumorigenesis. J Biol Chem. 2004;279:4877-86 pubmed
    ..These findings also provide a rationale for the poorer prognosis of those patients presenting with tumors harboring multiple Mdm2 transcripts. ..
  21. Meguid M, Ramos E, Laviano A, Varma M, Sato T, Chen C, et al. Tumor anorexia: effects on neuropeptide Y and monoamines in paraventricular nucleus. Peptides. 2004;25:261-6 pubmed
    ..We conclude that the increased 5-HT and the decreased DA and NPY concentrations in PVN are associated with cancer anorexia and that the NPY food stimulatory effect is linked to serotoninergic and dopaminergic systems in hypothalamus. ..
  22. Bui J, Uppaluri R, Hsieh C, Schreiber R. Comparative analysis of regulatory and effector T cells in progressively growing versus rejecting tumors of similar origins. Cancer Res. 2006;66:7301-9 pubmed
  23. Yoshikawa T, Noguchi Y, Satoh S. Inhibition of IRS-1 phosphorylation and the alterations of GLUT4 in isolated adipocytes from cachectic tumor-bearing rats. Biochem Biophys Res Commun. 1999;256:676-81 pubmed
  24. Sato T, Fetissov S, Meguid M, Miyata G, Chen C. Intra-supraoptic nucleus sulpiride improves anorexia in tumor-bearing rats. Neuroreport. 2001;12:2429-32 pubmed
    ..These data suggest that pharmacological manipulation of the hypothalamic dopaminergic system is feasible in amelioration of cancer anorexia. ..
  25. Charalabopoulos K, Karkabounas S, Ioachim E, Papalimneou V, Syrigos K, Evangelou A, et al. Antitumour and toxic effects on Wistar rats of two new platinum complexes. Eur J Clin Invest. 2002;32:129-33 pubmed
    ..All of these effects were reversible after drug discontinuation. The two new platinum complexes described here appear to have an effective antitumour activity without severe toxicity when tested on Wistar rats. ..
  26. Fang J, Sawa T, Akaike T, Akuta T, Sahoo S, Khaled G, et al. In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor. Cancer Res. 2003;63:3567-74 pubmed
    ..These findings suggest that tumor-targeted inhibition of HO activity could be achieved by using PEG-ZnPP, which induces apoptosis in solid tumors, probably through increased oxidative stress. ..
  27. Ho J, Konerding M, Gaumann A, Groth M, Liu W. Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice. Life Sci. 2004;75:1343-56 pubmed
    ..However, the expression of vascular endothelial cell growth factor (VEGF) in these tumors was suppressed. In conclusion, anti-angiogenesis should be one of the pathways through which PSP mediated its anti-tumor activity. ..
  28. Stettner N, Ranen E, Dank G, Lavy E, Brenner O, Harmelin A. Chemotherapeutic treatment of xenograft Spirocerca lupi-associated sarcoma in a murine model. Comp Med. 2007;57:267-71 pubmed
    ..lupi-associated sarcomas. We suggest that combination of doxorubicin or its pegylated form with surgical excision will improve the prognosis of dogs with this disease. ..
  29. Handler M, Yurchenco P, Iozzo R. Developmental expression of perlecan during murine embryogenesis. Dev Dyn. 1997;210:130-45 pubmed
    ..Collectively, the results indicate that perlecan may play crucial roles not only in vasculogenesis but also in the maturation and maintenance of differentiated tissues, including cartilage. ..
  30. Gu X, Schmitt M, Hiasa A, Nagata Y, Ikeda H, Sasaki Y, et al. A novel hydrophobized polysaccharide/oncoprotein complex vaccine induces in vitro and in vivo cellular and humoral immune responses against HER2-expressing murine sarcomas. Cancer Res. 1998;58:3385-90 pubmed
  31. Thews O, Kelleher D, Vaupel P. Erythropoietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors. Cancer Res. 2001;61:1358-61 pubmed
  32. Romanko Y, Tsyb A, Kaplan M, Popuchiev V. Effect of photodynamic therapy with photodithazine on morphofunctional parameters of M-1 sarcoma. Bull Exp Biol Med. 2004;138:584-9 pubmed
    ..The tissue and cellular targets for this agent are vascular wall, plasma membrane of tumor cells, and intracellular structures responsible for proliferation and biosynthesis. ..
  33. Mamou J, Oelze M, O Brien W, Zachary J. Extended three-dimensional impedance map methods for identifying ultrasonic scattering sites. J Acoust Soc Am. 2008;123:1195-1208 pubmed publisher
    ..Simulation results demonstrate the ability of the extended strategies to accurately predict FFs and estimate scatterer properties. Using the 3DZM methods, distinct FFs and scatterer properties were obtained for each tumor examined. ..
  34. Dzwonkowska B, Włodarski K. Peripheral blood and lymphatic organs in BALB/c mice during the progressive and regressive phases of Moloney sarcoma development. Folia Biol (Krakow). 2010;58:9-13 pubmed
    ..This was a long-lasting, although declining event, extending beyond tumor regression. ..
  35. van der Planken H, Hermens A. Lymphatic metastasis from tumors transplanted into the pre-irradiated footpad of the rat. Strahlenther Onkol. 1999;175:32-8 pubmed
    ..The influence of irradiation on regional metastasis formation seems to be "tumor bed" dependent for R-1 tumors. ..
  36. Ciernik I, Romero P, Berzofsky J, Carbone D. Ionizing radiation enhances immunogenicity of cells expressing a tumor-specific T-cell epitope. Int J Radiat Oncol Biol Phys. 1999;45:735-41 pubmed
    ..These findings indicate that IR can alter the immunogenicity of syngeneic normal as well as tumor forming fibroblasts in vivo, and support the view that ionizing radiation enhances immunogenicity of cellular tumor vaccines. ..
  37. Routes J, Ryan J, Ryan S, Nakamura M. MHC class I molecules on adenovirus E1A-expressing tumor cells inhibit NK cell killing but not NK cell-mediated tumor rejection. Int Immunol. 2001;13:1301-7 pubmed
    ..Therefore, a small population of NK cells that do not express Ly49A, Ly49G2 or Ly49C/I inhibitory receptors are likely responsible for the rejection of MCA-102-E1A-D(d) tumor cells in vivo. ..
  38. Kusmartsev S, Gabrilovich D. Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species. J Leukoc Biol. 2003;74:186-96 pubmed
    ..Thus, this is a first demonstration that tumors may prevent differentiation of antigen-presenting cells by increasing the level of endogenous H(2)O(2) in immature myeloid cells. ..
  39. Uenaka A, Nakayama E. Murine leukemia RL male 1 and sarcoma Meth A antigens recognized by cytotoxic T lymphocytes (CTL). Cancer Sci. 2003;94:931-6 pubmed
    ..S35 was a part of the retinoic acid-regulated nuclear matrix-associated protein (ramp). AT-1 CTL recognized the peptide LGAEAIFRL, which was derived from a newly created open reading frame due to the exon 14 extension. ..
  40. Svet Moldavskiĭ G. [Heterotransplantation of malignant tumors using mammalian embryos. 1958]. Vopr Onkol. 2005;51:414-6 pubmed
  41. Voronov E, Reich E, Dotan S, Dransh P, Cohen I, Huszar M, et al. Effects of IL-1 molecules on growth patterns of 3-MCA-induced cell lines: an interplay between immunogenicity and invasive potential. J Immunotoxicol. 2010;7:27-38 pubmed publisher
    ..This suggests that manipulation of IL-1 could be useful in anti-tumor therapy, by reducing invasiveness and promoting immunity against the malignant cells. ..
  42. Boven E, Pinedo H, van Hattum A, Scheffer P, Peters W, Erkelens C, et al. Characterization of human soft-tissue sarcoma xenografts for use in secondary drug screening. Br J Cancer. 1998;78:1586-93 pubmed
    ..Relatively low levels of topoisomerase IIalpha mRNA may partly account for intrinsic resistance against, for example, doxorubicin. Additional factors must contribute to moderate responsiveness to alkylating agents. ..
  43. Kurohane K, Tominaga A, Sato K, North J, Namba Y, Oku N. Photodynamic therapy targeted to tumor-induced angiogenic vessels. Cancer Lett. 2001;167:49-56 pubmed
    ..The current study indicates that 15 min PDT causes strong suppression of tumor growth, perhaps through damaging endothelial cells in the tumor neovasculature rather than through a direct cytotoxic effect on tumor cells. ..
  44. Zong Z, Matsui S, Katsuda S, Han J, Fujikawa Yamamoto K. Phorbol myristate induces apoptosis of taxol-resistant sarcoma cells in vitro. Eur J Pharmacol. 2004;489:3-11 pubmed
  45. Salomskaite Davalgiene S, Cepurniene K, Satkauskas S, Venslauskas M, Mir L. Extent of cell electrofusion in vitro and in vivo is cell line dependent. Anticancer Res. 2009;29:3125-30 pubmed
    ..It was observed that metastatic tumour cells easily electrofuse, suggesting that cell type-specific membrane properties and/or secretion of proteases determine the extent of electrofusion. ..
  46. Yokota T, Shibata N, Ura T, Takahari D, Shitara K, Muro K, et al. Cycleave polymerase chain reaction method is practically applicable for V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)/V-raf murine sarcoma viral oncogene homolog B1 (BRAF) genotyping in colorectal cancer. Transl Res. 2010;156:98-105 pubmed publisher
    ..In conclusion, cycleave PCR is practically applicable to KRAS/BRAF genotyping using small amounts of biopsied tumor cells. Care must be taken in the selection of pathological specimens for KRAS/BRAF testing. ..
  47. Krauss J, Stein J, Shu S. Tumor reactivity of immune T cells in short-term culture. Cancer Immunol Immunother. 1996;43:231-9 pubmed
    ..Thus T cells cultured after a single exposure to tumor represent an ideal population of cells for use in human adoptive immunotherapy trials...
  48. Vondrys P, Simova J, Takacova S, Jandlova T, Bubenik J. Recombinant interleukin-2 acts as an adjuvant and helps to increase the efficacy of tumour vaccines. Folia Biol (Praha). 1997;43:39-40 pubmed
    ..The local reaction was followed by a systemic response in the spleen characterized with an increase in TCR alpha beta + CD4+ lymphocytes...
  49. Walgenbach S, Bermes A, Bermes U, Bittinger F, Junginger T, Mueller Klieser W. Hyperlactacidaemia in isolated hyperthermic perfusion of tumour bearing rat limbs: a study of feasibility using a novel infusion solution. Int J Hyperthermia. 1999;15:109-22 pubmed
    ..In a methodological study the applicability of hyperlactacidaemia in isolated hyperthermic perfusion of tumour-bearing rat limbs was investigated...
  50. Rizell M, Hellstrand K, Lindner P, Naredi P. Monotherapy with histamine dihydrochloride suppresses in vivo growth of a rat sarcoma in liver and subcutis. Anticancer Res. 2002;22:1943-8 pubmed
  51. Lee Y, Yang H, Shin K, Choi H, Jung S, Kim Y, et al. Suppression of tumor growth by a new glycosaminoglycan isolated from the African giant snail Achatina fulica. Eur J Pharmacol. 2003;465:191-8 pubmed
    ..These results suggest that the antitumor activity of acharan sulfate may be related to the inhibition of angiogenesis...
  52. Kranjc S, Cemazar M, Grosel A, Scancar J, Sersa G. Electroporation of LPB sarcoma cells in vitro and tumors in vivo increases the radiosensitizing effect of cisplatin. Anticancer Res. 2003;23:275-81 pubmed
    ..Cisplatin is a cytotoxic drug with radiosensitizing effect. In this study a physical drug delivery system, electroporation, was used to facilitate cisplatin delivery into the cells and tumors with the aim of increasing radiation response...
  53. Skopinska Rozewska E, Chorostowska Wynimko J, Krotkiewski M, Rogala E, Sommer E, Demkow U, et al. Inhibitory effect of Greenland shark liver oil combined with squalen and arctic birch ashes on angiogenesis and L-1 sarcoma growth in Balb/c mice. Pol J Vet Sci. 2003;6:54-6 pubmed
    ..All substances tested, alone or in combinations, significantly diminished cutaneous angiogenesis induced by tumor cells, and tumor growth...
  54. Karner K, LeSnicar H, Cemazar M, Sersa G. Antitumour effectiveness of hyperthermia is potentiated by local application of electric pulses to LPB tumours in mice. Anticancer Res. 2004;24:2343-8 pubmed
    ..The aim of our study was to determine whether local application of electric pulses to tumours, which induce transient reduction of tumour perfusion, could potentiate the antitumour effectiveness of hyperthermia...
  55. Shu C, Guo S, Kim Y, Shelly S, Nijagal A, Ray P, et al. Visualization of a primary anti-tumor immune response by positron emission tomography. Proc Natl Acad Sci U S A. 2005;102:17412-7 pubmed
    ..The method we describe can be used to kinetically measure the induction and therapeutic modulations of cell-mediated immune responses...
  56. Weber A, Strehl A, Springer E, Hansen T, Schad A, Kirkpatrick C. Biomaterial-induced sarcomagenesis is not associated with microsatellite instability. Virchows Arch. 2009;454:195-201 pubmed publisher
    ..Thus, there is no evidence that a mutator phenotype is a hallmark of biomaterial-induced sarcomagenesis...
  57. Rubio R, Garcia Castro J, Gutierrez Aranda I, Paramio J, Santos M, Catalina P, et al. Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo. Cancer Res. 2010;70:4185-94 pubmed publisher
    ..Our findings define the differential roles of p53 and Rb in MSC transformation and offer proof-of-principle that MSCs could provide useful tools to dissect the sarcoma pathogenesis...
  58. Soderberg L. Increased tumor growth in mice exposed to inhaled isobutyl nitrite. Toxicol Lett. 1999;104:35-41 pubmed
    ..Similar inhalation exposures inhibited the tumoricidal activity of activated macrophages by 86%. The data suggest that exposure to abuser levels of a nitrite inhalant compromised tumor surveillance mechanisms...
  59. French J, Lacks G, Trempus C, Dunnick J, Foley J, Mahler J, et al. Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent. Carcinogenesis. 2001;22:99-106 pubmed
  60. Tanaka M, Kogawa K, Nakamura K, Nishihori Y, Kuribayashi K, Hagiwara S, et al. Anti-metastatic gene therapy utilizing subcutaneous inoculation of EC-SOD gene transduced autologous fibroblast suppressed lung metastasis of Meth-A cells and 3LL cells in mice. Gene Ther. 2001;8:149-56 pubmed
    ..Inoculation of EC-SOD-secreting fibroblasts suppressed both artificial and spontaneous metastatic lung nodules in mouse metastasis models. These data indicate the feasibility of anti-metastatic gene therapy utilizing the EC-SOD gene...
  61. Sadzuka Y, Yamashita Y, Kishimoto S, Fukushima S, Takeuchi Y, Sonobe T. [Glutamate transporter mediated increase of antitumor activity by theanine, an amino acid in green tea]. Yakugaku Zasshi. 2002;122:995-9 pubmed
    ..Therefore theanine enhances the antitumor activity not only of DOX but also of cisplatin or CPT-11...
  62. Clohisy D, Mantyh P. Bone cancer pain. Cancer. 2003;97:866-73 pubmed
    ..Development of an experimental model for studying this condition is critical to advancing an understanding of the mechanisms that cause pain in patients with malignant disease...
  63. Preda A, Wielopolski P, Ten Hagen T, van Vliet M, Veenland J, Ambagtsheer G, et al. Dynamic contrast-enhanced MRI using macromolecular contrast media for monitoring the response to isolated limb perfusion in experimental soft-tissue sarcomas. MAGMA. 2004;17:296-302 pubmed
    ..The data obtained in this experimental model suggest possible applications in the clinical setting, using the appropriate MR contrast agents...
  64. Sharykina N, Bukhtiarova T, Kudriavtseva I, Pavlovskaia G. [Cytostatic effects of bifolar and chlofiden. Effect on protein synthesis and cell cycle]. Ukr Biokhim Zh (1999). 2004;76:123-9 pubmed
    ..It was established that bifolar influenced all the phases of mitotic cycle and the sensitive phases of the mitosis itself, which are connected with the redistribution of genetic material...
  65. Betts G, Twohig J, van Den Broek M, Sierro S, Godkin A, Gallimore A. The impact of regulatory T cells on carcinogen-induced sarcogenesis. Br J Cancer. 2007;96:1849-54 pubmed
    ..These data offer strong support for the concept of immune surveillance and indicate that this process is limited by the inhibitory effect of FoxP3(+) regulatory T cells...
  66. Tozer G, Prise V, Lewis G, Xie S, Wilson I, Hill S. Nitric oxide synthase inhibition enhances the tumor vascular-damaging effects of combretastatin a-4 3-o-phosphate at clinically relevant doses. Clin Cancer Res. 2009;15:3781-90 pubmed publisher
    ..The therapeutic potential of combining the prototype tumor vascular-disrupting agent combretastatin A-4 3-O-phosphate (CA-4-P) with systemic nitric oxide synthase (NOS) inhibition was investigated preclinically...
  67. Hruska D, Sanchez J, Oelze M. Improved diagnostics through quantitative ultrasound imaging. Conf Proc IEEE Eng Med Biol Soc. 2009;2009:1956-9 pubmed publisher
    ..A novel coded excitation technique was used that improved the variance of estimates over conventional pulsing methods, e.g- , the variance of ESD estimates were reduced by a factor of up to 10...
  68. Naesens L, Bischofberger N, Augustijns P, Annaert P, Van den Mooter G, Arimilli M, et al. Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl)adenine in mice. Antimicrob Agents Chemother. 1998;42:1568-73 pubmed
  69. Mori M, Sakata I, Hirano T, Obana A, Nakajima S, Hikida M, et al. Photodynamic therapy for experimental tumors using ATX-S10(Na), a hydrophilic chlorin photosensitizer, and diode laser. Jpn J Cancer Res. 2000;91:753-9 pubmed
  70. Arimori K, Kuroki N, Kumamoto A, Tanoue N, Nakano M, Kumazawa E, et al. Excretion into gastrointestinal tract of irinotecan lactone and carboxylate forms and their pharmacodynamics in rodents. Pharm Res. 2001;18:814-22 pubmed
  71. Clark P, Menoret A. The inducible Hsp70 as a marker of tumor immunogenicity. Cell Stress Chaperones. 2001;6:121-5 pubmed
    ..These observations have a bearing on the proposed functional role of Hsp-peptide association in antigen processing and presentation by major histocompatibility complex I molecules under normal and stressful conditions...
  72. Siemann D, Rojiani A. Enhancement of radiation therapy by the novel vascular targeting agent ZD6126. Int J Radiat Oncol Biol Phys. 2002;53:164-71 pubmed
  73. Hannay J, Davis J, Yu D, Liu J, Fang B, Pollock R, et al. Isolated limb perfusion: a novel delivery system for wild-type p53 and fiber-modified oncolytic adenoviruses to extremity sarcoma. Gene Ther. 2007;14:671-81 pubmed
    ..In conclusion, therapeutic adenoviral gene therapy against limb borne human STS can be successfully delivered by ILP and warrants further investigation...
  74. Lopez G, Liu J, Ren W, Wei W, Wang S, Lahat G, et al. Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma. Clin Cancer Res. 2009;15:3472-83 pubmed publisher
    ..Consequently, we investigated the novel HDACi PCI-24781, alone/in combination with conventional chemotherapy, to determine its potential anti-STS-related effects and the underlying mechanisms involved...
  75. Uhlin Hansen L, Kusche Gullberg M, Berg E, Eriksson I, Kjellen L. Mouse mastocytoma cells synthesize undersulfated heparin and chondroitin sulfate in the presence of brefeldin A. J Biol Chem. 1997;272:3200-6 pubmed
    ..Brefeldin A had no effect on the glycosaminoglycan synthesis when used in a cell-free, microsomal fraction, indicating that brefeldin A does not interfere directly with the enzymes involved in the biosynthesis of glycosaminoglycans...
  76. Webster L, Hodgkiss R, Wilson G. Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo. Br J Cancer. 1998;77:227-34 pubmed
    ..In addition, the cell cycle distribution of NITP and BrdUrd labelling showed that hypoxic cells could progress through the cell cycle, although their rate of progression was slower than that of better oxygenated cells...
  77. Ludwig T, Fisher P, Ganesan S, Efstratiadis A. Tumorigenesis in mice carrying a truncating Brca1 mutation. Genes Dev. 2001;15:1188-93 pubmed
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