sarcoma

Summary

Summary: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.

Top Publications

  1. Lohberger B, Rinner B, Stuendl N, Absenger M, Liegl Atzwanger B, Walzer S, et al. Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma. PLoS ONE. 2012;7:e43664 pubmed publisher
    ..assay and fluorescence-activated cell sorting (FACS) analysis to isolate ALDH1(high) cells from five human sarcoma cell lines and one primary chordoma cell line. ALDH1(high) cells range from 0.3% (MUG-Chor1) to 4...
  2. Schuetze S, Zhao L, Chugh R, Thomas D, Lucas D, Metko G, et al. Results of a phase II study of sirolimus and cyclophosphamide in patients with advanced sarcoma. Eur J Cancer. 2012;48:1347-53 pubmed publisher
    Activation of the mammalian target of rapamycin (mTOR) pathway has been demonstrated in sarcoma. Trials using mTOR inhibitor in sarcoma have shown low objective response rates but progression-free survival (PFS) rates suggest cytostatic ..
  3. Kretschmer N, Rinner B, Stuendl N, Kaltenegger H, Wolf E, Kunert O, et al. Effect of costunolide and dehydrocostus lactone on cell cycle, apoptosis, and ABC transporter expression in human soft tissue sarcoma cells. Planta Med. 2012;78:1749-56 pubmed publisher
    ..lactone, which have been isolated from Saussurea lappa using activity-guided isolation, on three soft tissue sarcoma cell lines of various origins...
  4. Miettinen M, Wang Z, Sarlomo Rikala M, Abdullaev Z, Pack S, Fetsch J. ERG expression in epithelioid sarcoma: a diagnostic pitfall. Am J Surg Pathol. 2013;37:1580-5 pubmed publisher
    ..We also studied expression of other endothelial antigens in epithelioid sarcoma. ERG was expressed in 38% of epithelioid sarcomas (41/109), usually with a uniform nuclear staining, similar to ..
  5. Gronchi A, Miceli R, Shurell E, Eilber F, Eilber F, Anaya D, et al. Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets. J Clin Oncol. 2013;31:1649-55 pubmed publisher
    ..Data registered in three institutional prospective sarcoma databases were used. We included patients with primary localized RPS resected between 1999 and 2009...
  6. Bhatia K, Shiels M, Berg A, Engels E. Sarcomas other than Kaposi sarcoma occurring in immunodeficiency: interpretations from a systematic literature review. Curr Opin Oncol. 2012;24:537-46 pubmed publisher
    In immunodeficiency, an increased sarcoma risk is confirmed for Kaposi's sarcoma. Whether rates of other sarcoma subtypes are elevated in the setting of immunodeficiency is not known...
  7. Coosemans A, Van Calster B, Verbist G, Moerman P, Vergote I, Van Gool S, et al. Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma. Int J Gynecol Cancer. 2011;21:302-8 pubmed publisher
    Wilms tumor gene 1 (WT1) contributes to uterine sarcoma tumor biology. In this study, we aimed to clarify the prognostic value of WT1...
  8. Reed D, Altiok S. Metastatic soft tissue sarcoma chemotherapy: an opportunity for personalized medicine. Cancer Control. 2011;18:188-95 pubmed
    Soft tissue sarcoma (STS) includes biologically and histologically diverse mesenchymal tumors that are relatively chemotherapy-resistant compared with other sarcoma subtypes...
  9. Cheong D, Letson G. Computer-assisted navigation and musculoskeletal sarcoma surgery. Cancer Control. 2011;18:171-6 pubmed
    ..Computer-assisted navigation offers precise instrumentation, technology-oriented imaging systems, and powerful information processing, all of which can assist in decision making, preoperative planning, and surgical accuracy. ..

More Information

Publications111 found, 100 shown here

  1. Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A, Sudo A. The combined use of the neutrophil-lymphocyte ratio and C-reactive protein level as prognostic predictors in adult patients with soft tissue sarcoma. J Surg Oncol. 2013;108:481-5 pubmed publisher
    ..aim of this study was to determine whether the combined use of the C-reactive protein (CRP) level and neutrophil-lymphocyte ratio (NLR) before treatment predicts disease-specific survival in adult patients with soft tissue sarcoma (STS).
  2. Stebbing J, Paz K, Schwartz G, Wexler L, Maki R, Pollock R, et al. Patient-derived xenografts for individualized care in advanced sarcoma. Cancer. 2014;120:2006-15 pubmed publisher
    Patients with advanced, metastatic sarcoma have a poor prognosis, and the overall benefit from the few standard-of-care therapeutics available is small...
  3. Roomi M, Kalinovsky T, Monterrey J, Rath M, Niedzwiecki A. In vitro modulation of MMP-2 and MMP-9 in adult human sarcoma cell lines by cytokines, inducers and inhibitors. Int J Oncol. 2013;43:1787-98 pubmed publisher
    ..MMP-2 and MMP-9 secretion in chondrosarcoma (SW-1353), fibrosarcoma (HT-1080), liposarcoma (SW-872) and synovial sarcoma (SW-982) cell lines...
  4. Roomi M, Kalinovsky T, Rath M, Niedzwiecki A. In vitro modulation of MMP-2 and MMP-9 in pediatric human sarcoma cell lines by cytokines, inducers and inhibitors. Int J Oncol. 2014;44:27-34 pubmed publisher
    ..compounds included natural cytokines and growth factors, as well as chemical compounds applied in therapy of sarcoma and natural compounds that have demonstrated anticancer therapeutic potential...
  5. Forster M, Rashid O, Perez M, Choi J, Chaudhry T, Zager J. Chemosaturation with percutaneous hepatic perfusion for unresectable metastatic melanoma or sarcoma to the liver: a single institution experience. J Surg Oncol. 2014;109:434-9 pubmed publisher
    Patients with unresectable melanoma or sarcoma hepatic metastasis have a poor prognosis with few therapeutic options...
  6. Gronchi A, De Paoli A, Dani C, Merlo D, Quagliuolo V, Grignani G, et al. Preoperative chemo-radiation therapy for localised retroperitoneal sarcoma: a phase I-II study from the Italian Sarcoma Group. Eur J Cancer. 2014;50:784-92 pubmed publisher
    To study feasibility, safety and activity of the combination of high-dose long-infusion ifosfamide (HLI) and radiotherapy (RT) as preoperative treatment for resectable localised retroperitoneal sarcoma (RPS).
  7. Papp G, Krausz T, Stricker T, Szendroi M, Sapi Z. SMARCB1 expression in epithelioid sarcoma is regulated by miR-206, miR-381, and miR-671-5p on Both mRNA and protein levels. Genes Chromosomes Cancer. 2014;53:168-76 pubmed publisher
    Proximal type epithelioid sarcoma shares similarities with malignant rhabdoid tumor, including the lack of nuclear immunoreactivity of SMARCB1...
  8. Bartlett E, Roses R, Meise C, Fraker D, Kelz R, Karakousis G. Preoperative radiation for retroperitoneal sarcoma is not associated with increased early postoperative morbidity. J Surg Oncol. 2014;109:606-11 pubmed publisher
    Preoperative radiation (PR) in the management of retroperitoneal sarcoma (RPS) is controversial. Concern for increased perioperative morbidity may influence the decision to recommend PR...
  9. Cesne A, Judson I, Maki R, Grosso F, Schuetze S, Mehren M, et al. Trabectedin is a feasible treatment for soft tissue sarcoma patients regardless of patient age: a retrospective pooled analysis of five phase II trials. Br J Cancer. 2013;109:1717-24 pubmed publisher
    This retrospective pooled analysis assessed the effect of age on the efficacy and safety of trabectedin in young and elderly patients with recurrent advanced soft tissue sarcoma (STS).
  10. Yang X, La Rosa F, Genova E, Huber K, Schaack J, DeGregori J, et al. Simultaneous activation of Kras and inactivation of p53 induces soft tissue sarcoma and bladder urothelial hyperplasia. PLoS ONE. 2013;8:e74809 pubmed publisher
    ..To our surprise, there was a rapid development of a spindle-cell tumor with sarcoma characteristics near the suture site, within the pelvic area but outside the urinary track...
  11. Szkandera J, Gerger A, Liegl Atzwanger B, Absenger G, Stotz M, Samonigg H, et al. Validation of the prognostic relevance of plasma C-reactive protein levels in soft-tissue sarcoma patients. Br J Cancer. 2013;109:2316-22 pubmed publisher
    ..The aim of the present study was to validate the prognostic value of pre-operative plasma CRP levels on clinical outcome in a large cohort of soft-tissue sarcoma (STS) patients.
  12. Furu M, Kajita Y, Nagayama S, Ishibe T, Shima Y, Nishijo K, et al. Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. Oncogene. 2011;30:4015-25 pubmed publisher
    ..0093 by log-rank test). Knocking down the AFAP1L1 gene in sarcoma cells resulted in inhibition of the cell invasion, and forced expression of AFAP1L1 in immortalized human ..
  13. Lee Y, Park N, Lee H. Prognostic value of alternative lengthening of telomeres-associated biomarkers in uterine sarcoma and uterine carcinosarcoma. Int J Gynecol Cancer. 2012;22:434-41 pubmed publisher
    ..The goal of this study was to evaluate the frequency of ALT in uterine sarcoma and carcinosarcoma and to assess its association with clinical parameters.
  14. Ray Coquard I, Montesco M, Coindre J, Dei Tos A, Lurkin A, Ranchere Vince D, et al. Sarcoma: concordance between initial diagnosis and centralized expert review in a population-based study within three European regions. Ann Oncol. 2012;23:2442-9 pubmed
    ..The contribution of second opinion (SO) to improve diagnostic accuracy has been suggested for sarcoma but has never been established in population-based studies.
  15. Yamazaki H, Ohyama T, Tsuboi T, Taoka Y, Kohguchi D, Iguchi H, et al. Prostatic stromal sarcoma with neuroectodermal differentiation. Diagn Pathol. 2012;7:173 pubmed publisher
    Prostatic stromal sarcoma is a fairly rare tumor that constitutes approximately 0.1-0.2% of all prostatic cancers. Detailed characteristics of the tumor are still unclear due to its rarity...
  16. Gasljević G, Lamovec J, Jancar J. Undifferentiated (embryonal) liver sarcoma: synchronous and metachronous occurrence with neoplasms other than mesenchymal liver hamartoma. Ann Diagn Pathol. 2011;15:250-6 pubmed publisher
    Undifferentiated (embryonal) liver sarcoma (UELS) is a rare tumor that typically occurs in children. The association of UELS with neoplasm other than mesenchymal liver hamartoma is exceedingly rare...
  17. Schmidt W, Uddin M, Dysek S, Moser Thier K, Pirker C, Hoger H, et al. DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies. PLoS Genet. 2011;7:e1002042 pubmed publisher
    ..Primary MD-gene defects and strain background strongly influence sarcoma incidence, latency, localization, and gender prevalence...
  18. Predina J, Puc M, Bergey M, Sonnad S, Kucharczuk J, Staddon A, et al. Improved survival after pulmonary metastasectomy for soft tissue sarcoma. J Thorac Oncol. 2011;6:913-9 pubmed publisher
    Survival after pulmonary metastasectomy for soft tissue sarcoma (STS) has been lower than in osteosarcoma (14-40% versus 40-50%)...
  19. O Sullivan B, Griffin A, Dickie C, Sharpe M, Chung P, Catton C, et al. Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma. Cancer. 2013;119:1878-84 pubmed publisher
    ..wound complications, by minimizing dose to uninvolved tissues in adults with lower extremity soft tissue sarcoma. The primary endpoint was the development of an acute wound complication (WC)...
  20. Yu S, Song Z, Luo J, Dai Y, Li N. Over-expression of RAD51 or RAD54 but not RAD51/4 enhances extra-chromosomal homologous recombination in the human sarcoma (HT-1080) cell line. J Biotechnol. 2011;154:21-4 pubmed publisher
    ..extra-chromosomal HR evaluated by GFP extra-chromosomal HR was enhanced (110-245%) in different transfected Human sarcoma (HT-1080) cell colonies...
  21. Xie X, Ghadimi M, Young E, Belousov R, Zhu Q, Liu J, et al. Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma. Clin Cancer Res. 2011;17:5901-12 pubmed publisher
    Molecular deregulations underlying epithelioid sarcoma (ES) progression are poorly understood yet critically needed to develop new therapies...
  22. Miura Y, Keira Y, Ogino J, Nakanishi K, Noguchi H, Inoue T, et al. Detection of specific genetic abnormalities by fluorescence in situ hybridization in soft tissue tumors. Pathol Int. 2012;62:16-27 pubmed publisher
    ..FISH split-signal was 84% (129/154 cases) for the translocation-associated soft tissue tumors, such as Ewing's sarcoma/primitive neuroectodermal tumor, synovial sarcoma, alveolar rhabdomyosarcoma, myxoid liposarcoma, clear cell ..
  23. Chou Y, Liu C, Chen W, Chen T, Chen P, Wu H, et al. Follow-up after primary treatment of soft tissue sarcoma of extremities: impact of frequency of follow-up imaging on disease-specific survival. J Surg Oncol. 2012;106:155-61 pubmed publisher
    We explored the impact of frequency of surveillance imaging on disease-specific survival (DSS) in patients with extremity soft tissue sarcoma (STS).
  24. Iwasaki S, Sudo T, Miwa M, Ukita M, Morimoto A, Tamada M, et al. Endometrial stromal sarcoma: clinicopathological and immunophenotypic study of 16 cases. Arch Gynecol Obstet. 2013;288:385-91 pubmed publisher
    Endometrial stromal sarcomas (ESSs) are rare tumors and are divided into two groups: low-grade endometrial stromal sarcoma (ESS-LG) and undifferentiated endometrial sarcoma (UES)...
  25. Pressey J, Anderson J, Crossman D, Lynch J, Barr F. Hedgehog pathway activity in pediatric embryonal rhabdomyosarcoma and undifferentiated sarcoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2011;57:930-8 pubmed publisher
    ..To investigate the role of Hh pathway signaling in pediatric RMS and undifferentiated sarcoma (US) tumors, the expression of Hh pathway targets GLI1 and PTCH was measured...
  26. Antonescu C, Zhang L, Nielsen G, Rosenberg A, Dal Cin P, Fletcher C. Consistent t(1;10) with rearrangements of TGFBR3 and MGEA5 in both myxoinflammatory fibroblastic sarcoma and hemosiderotic fibrolipomatous tumor. Genes Chromosomes Cancer. 2011;50:757-64 pubmed publisher
    ..for superficial soft tissue of distal extremities and frequent local recurrences, myxoinflammatory fibroblastic sarcoma (MIFS) and hemosiderotic fibrolipomatous tumor (HFLT) have distinct morphologic appearances...
  27. Tse K, Crawford R, Ngan H. Staging of uterine sarcomas. Best Pract Res Clin Obstet Gynaecol. 2011;25:733-49 pubmed publisher
    Uterine sarcomas comprise leiomyosarcoma, endometrial stromal sarcoma, adenosarcoma, undifferentiated endometrial sarcoma, and their variants...
  28. Kaushal S, Sharma M, Mathur S, Rastogi S, Bal C, Chumber S. Anaplastic transformation of metastatic papillary thyroid carcinoma at shoulder mimicking soft tissue sarcoma. Indian J Pathol Microbiol. 2011;54:796-9 pubmed publisher
  29. Mavrogenis A, Soultanis K, Patapis P, Guerra G, Fabbri N, Ruggieri P, et al. Pelvic resections. Orthopedics. 2012;35:e232-43 pubmed publisher
    ..Reconstruction options after major pelvic resections have also evolved, but they remain difficult, especially when the acetabulum is involved. ..
  30. Nakamura T, Grimer R, Gaston C, FRANCIS M, Charman J, Graunt P, et al. The value of C-reactive protein and comorbidity in predicting survival of patients with high grade soft tissue sarcoma. Eur J Cancer. 2013;49:377-85 pubmed publisher
    ..treatment predicted the overall disease-specific survival and local tumour control in high grade soft tissue sarcoma patients. A total of 332 primary adult soft tissue sarcoma patients were retrospectively reviewed...
  31. Ognjanovic S, Olivier M, Bergemann T, Hainaut P. Sarcomas in TP53 germline mutation carriers: a review of the IARC TP53 database. Cancer. 2012;118:1387-96 pubmed publisher
    b>Sarcoma is the index diagnosis of Li-Fraumeni syndrome (LFS), a familial predisposition to cancer that also includes brain cancer, breast cancer, and adrenal cortical carcinoma...
  32. Riedel R. Targeted agents for sarcoma: is individualized therapy possible in such a diverse tumor type?. Semin Oncol. 2011;38 Suppl 3:S30-42 pubmed publisher
    A wide variety of cytogenetic abnormalities and molecular pathways have been implicated in the pathogenesis of sarcoma, and significant progress has been made in the past decade toward identifying potential therapeutic targets...
  33. van der Graaf W, Blay J, Chawla S, Kim D, Bui Nguyen B, Casali P, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2012;379:1879-86 pubmed publisher
    ..tyrosine kinase inhibitor, has single-agent activity in patients with advanced non-adipocytic soft-tissue sarcoma. We investigated the effect of pazopanib on progression-free survival in patients with metastatic non-adipocytic ..
  34. Idowu O, Ding Q, Taktak A, Chandrasekar C, Yin Q. Clinical implication of pretreatment neutrophil to lymphocyte ratio in soft tissue sarcoma. Biomarkers. 2012;17:539-44 pubmed publisher
    ..as a prognostic indicator in malignancies whereas; its association with extremity and trunk soft tissue sarcoma remain unclear...
  35. Scurr M. Histology-driven chemotherapy in soft tissue sarcomas. Curr Treat Options Oncol. 2011;12:32-45 pubmed publisher
    ..and ifosfamide are the two chemotherapy drugs that have consistently demonstrated activity in "soft tissue sarcoma" (STS)...
  36. Jaakkola S, Lyytinen H, Pukkala E, Ylikorkala O. Use of estradiol-progestin therapy associates with increased risk for uterine sarcomas. Gynecol Oncol. 2011;122:260-3 pubmed publisher
    ..We therefore evaluated the association of estradiol-progestin therapy (EPT) with the risk of uterine sarcoma in nation-wide cohort study.
  37. Srivastav A, Kass P, McGill L, Farver T, Kent M. Comparative vaccine-specific and other injectable-specific risks of injection-site sarcomas in cats. J Am Vet Med Assoc. 2012;241:595-602 pubmed publisher
    ..To compare associations between vaccine types and other injectable drugs with development of injection-site sarcomas in cats...
  38. Tanaka S, Takasawa A, Fukasawa Y, Hasegawa T, Sawada N. An undifferentiated embryonal sarcoma of the liver containing adipophilin-positive vesicles in an adult with massive sinusoidal invasion. Int J Clin Exp Pathol. 2012;5:824-9 pubmed
    Undifferentiated embryonal sarcoma of the liver (UESL) is a malignant mesenchymal tumor that occurs typically in children and rarely in adults...
  39. Al Ibraheem A, Buck A, Benz M, Rudert M, Beer A, Mansour A, et al. (18) F-fluorodeoxyglucose positron emission tomography/computed tomography for the detection of recurrent bone and soft tissue sarcoma. Cancer. 2013;119:1227-34 pubmed publisher
    The clinical utility of modern hybrid imaging modalities for detecting recurrent bone or soft tissue sarcoma remains to be determined...
  40. Paumier A, Le Péchoux C, Beaudre A, Negretti L, Ferreira I, Roberti E, et al. IMRT or conformal radiotherapy for adjuvant treatment of retroperitoneal sarcoma?. Radiother Oncol. 2011;99:73-8 pubmed publisher
    ..between three-dimensional conformal radiotherapy (3DCRT), intensity modulated radiotherapy (IMRT) with six coplanar beams (6b-IMRT) and IMRT with nine coplanar beams (9b-IMRT) during adjuvant radiotherapy for retroperitoneal sarcoma.
  41. Gadducci A. Prognostic factors in uterine sarcoma. Best Pract Res Clin Obstet Gynaecol. 2011;25:783-95 pubmed publisher
    ..pathological and biological variables other than tumour stage in the different histological subtypes of uterine sarcoma. Immunomarkers for cell proliferation and apoptosis have been tested for the identification of tumours with ..
  42. Qureshi Y, Huddy J, Miller J, Strauss D, Thomas J, Hayes A. Unplanned excision of soft tissue sarcoma results in increased rates of local recurrence despite full further oncological treatment. Ann Surg Oncol. 2012;19:871-7 pubmed publisher
    Unplanned excision of soft tissue sarcoma (STS) accounts for up to 40% of all initial operations for STS and is undertaken when the mass is presumed to be benign. The effect this has on outcome has never been fully established.
  43. Martin C, Morcuende J, Buckwalter J, Miller B. Prereferral MRI use in patients with musculoskeletal tumors is not excessive. Clin Orthop Relat Res. 2012;470:3240-5 pubmed publisher
    ..We accepted as necessary any MRI for a primary bone sarcoma, for biopsy-proven soft tissue sarcomas, for soft tissue masses greater than 5 cm in diameter, for soft tissue ..
  44. Greither T, Koser F, Kappler M, Bache M, Lautenschlager C, Göbel S, et al. Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients. BMC Cancer. 2012;12:272 pubmed publisher
    ..We measured the expression of Piwi-like mRNAs (Piwi-like 2-4) in 125 soft tissue sarcoma (STS) samples by qPCRs...
  45. Biau D, Ferguson P, Turcotte R, Chung P, Isler M, Riad S, et al. Adverse effect of older age on the recurrence of soft tissue sarcoma of the extremities and trunk. J Clin Oncol. 2011;29:4029-35 pubmed publisher
    To examine the effect of age on the recurrence of soft tissue sarcoma in the extremities and trunk.
  46. Dagan R, Indelicato D, McGee L, Morris C, Kirwan J, Knapik J, et al. The significance of a marginal excision after preoperative radiation therapy for soft tissue sarcoma of the extremity. Cancer. 2012;118:3199-207 pubmed publisher
    Marginal excision of soft tissue sarcoma (STS), defined as resection through the tumor pseudocapsule or surrounding reactive tissue, increases the likelihood of local recurrence and necessitates re-excision or postoperative radiation...
  47. Grabellus F, Stylianou E, Umutlu L, Sheu S, Lehmann N, Taeger G, et al. Size-based clinical response evaluation is insufficient to assess clinical response of sarcomas treated with isolated limb perfusion with TNF-? and melphalan. Ann Surg Oncol. 2012;19:3375-85 pubmed publisher
    ..Size-based clinical response evaluation is insufficient to assess clinical response in TM-ILP-treated sarcomas. The size changes of tumors after therapy reflect the type of regression rather than the extent of destruction. ..
  48. Binitie O, Tejiram S, Conway S, Cheong D, Temple H, Letson G. Adult soft tissue sarcoma local recurrence after adjuvant treatment without resection of core needle biopsy tract. Clin Orthop Relat Res. 2013;471:891-8 pubmed publisher
    ..Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence. ..
  49. Demetri G, Chawla S, Ray Coquard I, Le Cesne A, Staddon A, Milhem M, et al. Results of an international randomized phase III trial of the mammalian target of rapamycin inhibitor ridaforolimus versus placebo to control metastatic sarcomas in patients after benefit from prior chemotherapy. J Clin Oncol. 2013;31:2485-92 pubmed publisher
    ..Ridaforolimus delayed tumor progression to a small statistically significant degree in patients with metastatic sarcoma who experienced benefit with prior chemotherapy...
  50. Trivedi P, Pasricha S, Gupta A. Spermatocytic seminoma associated with undifferentiated sarcoma: a rare case report. Indian J Pathol Microbiol. 2011;54:138-40 pubmed publisher
    ..Orchidectomy was performed and after 9 months, the patient presented with recurrent scrotal mass with bilateral pulmonary metastases...
  51. Kim H, Kim J, Park E, Hur Y, Koh Y, Cho C, et al. Undifferentiated embryonal sarcoma of the liver presenting as a hemorrhagic cystic tumor in an adult. Hepatobiliary Pancreat Dis Int. 2011;10:657-60 pubmed
    Undifferentiated embryonal sarcoma (UES) of the liver is a rare, highly malignant neoplasm with a poor prognosis occurring almost exclusively in late childhood (6-10 years of age)...
  52. Rubio R, Gutierrez Aranda I, Sáez Castillo A, Labarga A, Rosu Myles M, Gonzalez Garcia S, et al. The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development. Oncogene. 2013;32:4970-80 pubmed publisher
    ..we hypothesized that the source of MSCs and/or the cell differentiation stage could determine the phenotype of sarcoma development...
  53. Sullivan L, Folpe A, Pawel B, Judkins A, Biegel J. Epithelioid sarcoma is associated with a high percentage of SMARCB1 deletions. Mod Pathol. 2013;26:385-92 pubmed publisher
    ..However, investigations of SMARCB1 gene alterations in epithelioid sarcoma have produced conflicting results...
  54. Ohnstad H, Castro R, Sun J, Heintz K, Vassilev L, Bjerkehagen B, et al. Correlation of TP53 and MDM2 genotypes with response to therapy in sarcoma. Cancer. 2013;119:1013-22 pubmed publisher
    ..Relatively few sarcomas harbor TP53 (tumor protein p53) mutations, but in many cases, amplification of MDM2 (murine double minute 2) effectively inactivate p53. The p53 pathway activity can also be affected by normal genetic variation...
  55. Miłoszewska J, Przybyszewska M, Gos M, Swoboda P, Trembacz H. TrkB expression level correlates with metastatic properties of L1 mouse sarcoma cells cultured in non-adhesive conditions. Cell Prolif. 2013;46:146-52 pubmed publisher
    ..A mouse sarcoma, stable, adherent L1 cell line, derived from a spontaneously arisen Balb/c mouse lung tumour, was established in ..
  56. Paryani N, Zlotecki R, Swanson E, Morris C, Grobmyer S, Hochwald S, et al. Multimodality local therapy for retroperitoneal sarcoma. Int J Radiat Oncol Biol Phys. 2012;82:1128-34 pubmed publisher
    ..This study updates our institutional experience using multimodality local therapy for resectable retroperitoneal sarcoma and identifies prognostic factors impacting disease control and survival.
  57. Deroose J, van Geel A, Burger J, Eggermont A, Verhoef C. Isolated limb perfusion with TNF-alpha and melphalan for distal parts of the limb in soft tissue sarcoma patients. J Surg Oncol. 2012;105:563-9 pubmed publisher
    ..Tumor necrosis factor-alpha (TNF) and melphalan-based isolated limb perfusion (TM-ILP) is effective in locally advanced STS of the extremities. We report the results of TM-ILP for STS in the most distal parts of the limb...
  58. Fleuren E, Versleijen Jonkers Y, van de Luijtgaarden A, Molkenboer Kuenen J, Heskamp S, Roeffen M, et al. Predicting IGF-1R therapy response in bone sarcomas: immuno-SPECT imaging with radiolabeled R1507. Clin Cancer Res. 2011;17:7693-703 pubmed publisher
  59. Cioffi A, Italiano A. Clinical and pharmacokinetic evaluation of trabectedin for the treatment of soft-tissue sarcoma. Expert Opin Drug Metab Toxicol. 2012;8:113-22 pubmed publisher
    Forty percent of patients with soft-tissue sarcoma (STS) will develop metastatic disease. Furthermore, up until 2007, doxorubicin and ifosfamide were the only drugs approved for the treatment of patients with advanced STS...
  60. Schwartz G, Tap W, Qin L, Livingston M, Undevia S, Chmielowski B, et al. Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial. Lancet Oncol. 2013;14:371-82 pubmed publisher
  61. Raj S, Zhou X, Bueso Ramos C, Ravi V, Patel S, Benjamin R, et al. Prognostic significance of elevated D-dimer for survival in patients with sarcoma. Am J Clin Oncol. 2012;35:462-7 pubmed
    ..We examined the prognostic significance of baseline plasma D-dimer levels for predicting survival in sarcoma.
  62. O SULLIVAN F, Wolsztynski E, O SULLIVAN J, Richards T, Conrad E, Eary J. A statistical modeling approach to the analysis of spatial patterns of FDG-PET uptake in human sarcoma. IEEE Trans Med Imaging. 2011;30:2059-71 pubmed publisher
    Clinical experience with positron emission tomography (PET) scanning of sarcoma, using fluorodeoxyglucose (FDG), has established spatial heterogeneity in the standardized uptake values within the tumor mass as a key prognostic indicator ..
  63. Kim S, Ott H, Wright C, Wain J, Morse C, Gaissert H, et al. Pulmonary resection of metastatic sarcoma: prognostic factors associated with improved outcomes. Ann Thorac Surg. 2011;92:1780-6; discussion 1786-7 pubmed publisher
    There are few data to predict the benefit of pulmonary metastasectomy in patients with extrathoracic sarcoma. This study analyzes prognostic factors associated with improved outcomes.
  64. Gentschev I, Adelfinger M, Josupeit R, Rudolph S, Ehrig K, Donat U, et al. Preclinical evaluation of oncolytic vaccinia virus for therapy of canine soft tissue sarcoma. PLoS ONE. 2012;7:e37239 pubmed publisher
    ..In this study we describe the establishment of an in vivo model of canine soft tissue sarcoma (CSTS) using the new isolated cell line STSA-1 and the analysis of the virus-mediated oncolytic and immunological ..
  65. Friedman M, Kyriakos M, Matava M, McDonald D, Jennings J, Wessell D. Intra-articular synovial sarcoma. Skeletal Radiol. 2013;42:859-67 pubmed publisher
    A case of right knee intra-articular synovial sarcoma in a 26-year-old man is reported. The patient had experienced 12 to 18 months of chronic posterior right knee pain with flexion contracture of the leg...
  66. Chawla S, Staddon A, Hendifar A, Messam C, Patwardhan R, Kamel Y. Results of a phase I dose escalation study of eltrombopag in patients with advanced soft tissue sarcoma receiving doxorubicin and ifosfamide. BMC Cancer. 2013;13:121 pubmed publisher
    ..tolerability of eltrombopag, an oral, nonpeptide, thrombopoietin receptor agonist, in patients with advanced soft tissue sarcoma (STS) and thrombocytopenia due to treatment with doxorubicin and ifosfamide (AI) combination chemotherapy.
  67. Gan H, Zhang J, Zhou Q, Xiao W, Gao Y, Liu S, et al. Surgical treatment of pulmonary artery sarcoma. J Thorac Cardiovasc Surg. 2011;142:1469-72 pubmed publisher
    The study objectives were to characterize the prognostic perspectives of pulmonary artery sarcoma and to investigate the effect of distal embolectomy on the prognosis of surgical treatment of pulmonary artery sarcoma.
  68. Palussiere J, Italiano A, Descat E, Ferron S, Cornelis F, Avril A, et al. Sarcoma lung metastases treated with percutaneous radiofrequency ablation: results from 29 patients. Ann Surg Oncol. 2011;18:3771-7 pubmed publisher
    We aimed to determine safety and efficacy of radiofrequency ablation (RFA) in the treatment of lung metastases arising from sarcoma.
  69. Wasif N, Tamurian R, Christensen S, Do L, Martinez S, Chen S, et al. Influence of specialty and clinical experience on treatment sequencing in the multimodal management of soft tissue extremity sarcoma. Ann Surg Oncol. 2012;19:504-10 pubmed publisher
    Although multimodal management of extremity soft tissue sarcoma (STS) is the standard of care, considerable variation exists in the sequencing of radiotherapy (RT) or chemotherapy (CT)...
  70. O Sullivan T, Dunn G, LACOURSIERE D, Schreiber R, Bui J. Cancer immunoediting of the NK group 2D ligand H60a. J Immunol. 2011;187:3538-45 pubmed publisher
    ..that the expression of the NKG2D ligand H60a was more heterogeneous in groups of unedited 3'-methylcholanthrene sarcoma cell lines compared with that in edited 3'-methylcholanthrene sarcoma cell lines (i.e...
  71. Kon Z, Martin L. Resection for thoracic metastases from sarcoma. Oncology (Williston Park). 2011;25:1198-204 pubmed
    b>Sarcoma metastasizes to the lungs in 20% to 40% of patients and in most cases does not involve any other organ. Systemic chemotherapy is of unproven benefit for stage IV sarcoma...
  72. Mastrangelo G, Coindre J, Ducimetière F, Dei Tos A, Fadda E, Blay J, et al. Incidence of soft tissue sarcoma and beyond: a population-based prospective study in 3 European regions. Cancer. 2012;118:5339-48 pubmed publisher
    The objectives of this study were to measure the incidence of sarcomas, including viscerally sited tumors that are not reported in cancer statistics, and to draw explanatory clues from a large and reliable sarcoma incidence data set.
  73. Reichardt P. The treatment of uterine sarcomas. Ann Oncol. 2012;23 Suppl 10:x151-7 pubmed
    ..Endometrial stromal sarcomas are usually hormonal receptor positive, which allows endocrine therapy in most cases...
  74. Frith A, Hirbe A, Van Tine B. Novel pathways and molecular targets for the treatment of sarcoma. Curr Oncol Rep. 2013;15:378-85 pubmed publisher
    ..peripheral nerve sheath tumors, CDK4 in alveolar rhabdomyosarcoma, cMET regulation in alveolar soft parts sarcoma, the metabolic abnormalities in wild-type/SHD GIST, and the lack of argininosuccinate synthetase 1 expression ..
  75. Garamszegi N, Garamszegi S, Scully S. Matrix metalloproteinase-1 contribution to sarcoma cell invasion. J Cell Mol Med. 2012;16:1331-41 pubmed publisher
    ..These results indicate that MMP-1 directional delivery to podia structures is involved in the invasive activity of sarcoma cells, and this process is prenylation sensitive.
  76. Squillace R, Miller D, Cookson M, Wardwell S, Moran L, Clapham D, et al. Antitumor activity of ridaforolimus and potential cell-cycle determinants of sensitivity in sarcoma and endometrial cancer models. Mol Cancer Ther. 2011;10:1959-68 pubmed publisher
    ..rapamycin analogue that potently inhibits mTOR and has shown significant activity in patients with metastatic sarcoma and endometrial cancer, two diseases where high unmet need remains...
  77. Chawla S, Staddon A, Baker L, Schuetze S, Tolcher A, D Amato G, et al. Phase II study of the mammalian target of rapamycin inhibitor ridaforolimus in patients with advanced bone and soft tissue sarcomas. J Clin Oncol. 2012;30:78-84 pubmed publisher
    ..This multicenter, open-label, single-arm, phase II trial was conducted to assess the antitumor activity of ridaforolimus in patients with distinct subtypes of advanced sarcomas...
  78. Wang Y, Xu H, Liu H, Wang Y, Sun J, He Z. Efficacy and biodistribution of tocopheryl polyethylene glycol succinate noncovalent functionalized single walled nanotubes loading doxorubicin in sarcoma bearing mouse model. J Biomed Nanotechnol. 2012;8:450-7 pubmed
    ..ICR mice bearing mouse sarcoma tumor were subjected to intratumoral injection of TPGS-SWNTs-Dox...
  79. Miller B, Carmody Soni E, Reith J, Gibbs C, Scarborough M. CT scans for pulmonary surveillance may be overused in lower-grade sarcoma. Iowa Orthop J. 2012;32:28-34 pubmed
    Chest CT scans are often used to monitor patients after excision of a sarcoma. Although sensitive, CT scans are more expensive than chest radiographs and are associated with possible health risks from a higher radiation dose...
  80. Lohberger B, Rinner B, Stuendl N, Kaltenegger H, Steinecker Frohnwieser B, Bernhart E, et al. Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells. PLoS ONE. 2013;8:e66300 pubmed publisher
    ..In addition, the invasion potential was significantly reduced after treatment with both sesquiterpene lactones as investigated by the HTS FluoroBlock™ insert system. ..
  81. Yang C, Choy E, Hornicek F, Wood K, Schwab J, Liu X, et al. Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines. Anticancer Res. 2011;31:1115-23 pubmed
    The antitumor activity of histone deacetylase inhibitors (HDACI) on multidrug-resistant sarcoma cell lines has not been previously described...
  82. Ferrari A, Sultan I, Huang T, Rodriguez Galindo C, Shehadeh A, Meazza C, et al. Soft tissue sarcoma across the age spectrum: a population-based study from the Surveillance Epidemiology and End Results database. Pediatr Blood Cancer. 2011;57:943-9 pubmed publisher
    ..Soft tissue sarcomas (STS) are a heterogeneous group of mesenchymal malignancies that occur throughout the lifespan. The impact of age on disease features and outcome is unclear...
  83. Lorenzi L, Lonardi S, Petrilli G, Tanda F, Bella M, Laurino L, et al. Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders. Hum Pathol. 2012;43:209-15 pubmed publisher
    We report three cases of follicular dendritic cell sarcoma (FDCS) showing a hitherto undescribed histological pattern consisting of nodular tumor growth associated with small B lymphocytes...
  84. Deroose J, Eggermont A, van Geel A, Burger J, Den Bakker M, de Wilt J, et al. Long-term results of tumor necrosis factor alpha- and melphalan-based isolated limb perfusion in locally advanced extremity soft tissue sarcomas. J Clin Oncol. 2011;29:4036-44 pubmed publisher
    ..This study reports the long-term results of 231 TM-ILPs for locally advanced extremity STS...
  85. Kelly A, Breitkopf S, Yuan M, Goldsmith J, Spentzos D, Asara J. Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcoma. PLoS ONE. 2011;6:e25357 pubmed publisher
    ..Our study supports the notion that reliable and broadly informative metabolomic data may be acquired from FFPE soft tissue sarcoma specimens, a finding that is likely to be extended to other malignancies.
  86. Samartzis D, Nishi N, Hayashi M, Cologne J, Cullings H, Kodama K, et al. Exposure to ionizing radiation and development of bone sarcoma: new insights based on atomic-bomb survivors of Hiroshima and Nagasaki. J Bone Joint Surg Am. 2011;93:1008-15 pubmed
    Radiation-induced bone sarcoma has been associated with high doses of ionizing radiation from therapeutic or occupation-related exposures...
  87. May L, Wang M, Albano E, Garrington T, Dishop M, Macy M. Undifferentiated sarcoma of the liver: a single institution experience using a uniform treatment approach. J Pediatr Hematol Oncol. 2012;34:e114-6 pubmed publisher
    Undifferentiated (embryonal) sarcoma of the liver is a rare malignant tumor, most commonly seen in children aged 6 to 10 years...
  88. Tirumani S, Ojili V, Shanbhogue A, Fasih N, Ryan J, Reinhold C. Current concepts in the imaging of uterine sarcoma. Abdom Imaging. 2013;38:397-411 pubmed publisher
    ..The major types of uterine sarcomas include leiomyosarcoma, low-grade endometrial stromal sarcoma, undifferentiated endometrial sarcoma, adenosarcoma and carcinosarcoma...
  89. Shah S, Jagannathan J, Krajewski K, O Regan K, George S, Ramaiya N. Uterine sarcomas: then and now. AJR Am J Roentgenol. 2012;199:213-23 pubmed publisher
    ..We attempt to provide a longitudinal imaging overview, from initial presentation to follow-up. Imaging features are also described of response to traditional therapeutic agents and newer targeted agents...
  90. Yang G, Li J, Jin H, Ding H. Is mammary not otherwise specified-type sarcoma with CD10 expression a distinct entity? A rare case report with immunohistochemical and ultrastructural study. Diagn Pathol. 2013;8:14 pubmed publisher
    Mammary sarcoma is extremely rare and the diagnosis is established only after metaplastic carcinomas and malignant phyllodes tumours are excluded...
  91. Suehara Y. Proteomic analysis of soft tissue sarcoma. Int J Clin Oncol. 2011;16:92-100 pubmed publisher
  92. Kim H, Joo S, Yang D, Lee S, Choi S, Lim S. Carcinosarcoma of the pancreas: a unique case with emphasis on metaplastic transformation and the presence of undifferentiated pleomorphic high-grade sarcoma. J Gastrointestin Liver Dis. 2011;20:197-200 pubmed
    ..These findings suggested that the pancreatic carcinosarcoma could be of monoclonal origin, and that the sarcomatous component might have arisen from metaplastic transformation of the carcinomatous component...