smooth muscle tumor

Summary

Summary: A tumor composed of smooth muscle tissue, as opposed to leiomyoma, a tumor derived from smooth muscle.

Top Publications

  1. Berretta R, Rolla M, Merisio C, Giordano G, Nardelli G. Uterine smooth muscle tumor of uncertain malignant potential: a three-case report. Int J Gynecol Cancer. 2008;18:1121-6 pubmed
    ..At present, no final consensus has been reached on the choice of the best strategy for surgery and adjuvant therapy...
  2. Mayerhofer K, Lozanov P, Bodner K, Bodner Adler B, Kimberger O, Czerwenka K. Ki-67 expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS). Acta Obstet Gynecol Scand. 2004;83:1085-8 pubmed
  3. O Neill C, McBride H, Connolly L, McCluggage W. Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology. 2007;50:851-8 pubmed
    ..p16 expression was also compared with that of p53 and MIB1...
  4. Kumar S, Santi M, Vezina G, Rosser T, Chandra R, Keating R. Epstein-Barr virus-associated smooth muscle tumor of the basal ganglia in an HIV+ child: case report and review of the literature. Pediatr Dev Pathol. 2004;7:198-203 pubmed
    We describe the clinicopathologic features of an Epstein-Barr virus (EBV)-associated smooth muscle tumor arising in the basal ganglia of a 10-year-old human immunodeficiency virus (HIV)-positive child...
  5. Harirah H, Jones D, Donia S, Bahado Singh R. Intraplacental smooth muscle tumor. A case report. J Reprod Med. 2001;46:937-40 pubmed
    ..Chorioangioma is the leading diagnosis for circumscribed placental lesion noted on ultrasound. Other rare intraplacental tumors may have a significant clinical impact on the mother and fetus...
  6. Bodner Adler B, Bodner K, Kimberger O, Czerwenka K, Leodolter S, Mayerhofer K. Expression of matrix metalloproteinases in patients with uterine smooth muscle tumors: an immunohistochemical analysis of MMP-1 and MMP-2 protein expression in leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcom. J Soc Gynecol Investig. 2004;11:182-6 pubmed
    ..We compared the expression of MMP-1 and MMP-2 protein in patients with leiomyoma, uterine smooth muscle tumor of uncertain malignant potential (STUMP), and leiomyosarcoma (LMS).
  7. Al Daraji W, Salman W, Nakhuda Y, Zaman F, Eyden B. Primary smooth muscle tumor of the pleura: a clinicopathological case report with ultrastructural observations and a review of the literature. Ultrastruct Pathol. 2005;29:389-98 pubmed
    Primary smooth muscle tumor of the pleura is exceptionally rare. The authors describe a primary smooth muscle tumor of the pleura that was discovered incidentally on chest X-ray in a 73-year-old man...
  8. Gallien S, Zuber B, Polivka M, Lagrange Xelot M, Thiebault J, Bertheau P, et al. Multifocal Epstein-Barr virus-associated smooth muscle tumor in adults with AIDS: case report and review of the literature. Oncology. 2008;74:167-76 pubmed publisher
    ..The aim of this study was to provide a systematic review of Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) in human immunodeficiency virus (HIV)-infected adults, focusing on clinical and histopathologic features and outcome...
  9. Belingheri M, Comoli P, Locatelli F, Baldanti F, Martina V, Giani M, et al. Successful medical treatment of EBV smooth muscle tumor in a renal transplant recipient. Pediatr Transplant. 2010;14:E101-4 pubmed publisher
    ..We report the case of a 17-yr-old kidney transplant recipient diagnosed as having an EBV-SMT inside the renal graft, which was successfully managed by minimizing isolated immunosuppression...

More Information

Publications98

  1. Khunamornpong S, Sukpan K, Suprasert P, Shuangshoti S, Pintong J, Siriaunkgul S. Epstein-Barr virus-associated smooth muscle tumor presenting as a vulvar mass in an acquired immunodeficiency syndrome patient: a case report. Int J Gynecol Cancer. 2007;17:1333-7 pubmed
    ..EBV-SMT should be included in the differential diagnoses of mesenchymal tumor in patients with immunosuppression and in the differential diagnoses of smooth muscle tumor in uncommon sites, including the vulva.
  2. Harrington A, Bell E, Suchi M, Behmaram B, Uyar D. Multifocal vulvar smooth muscle tumor with an unusual intravascular growth pattern and multiple local recurrences in a 10-year-old child: a diagnostic dilemma. Pediatr Dev Pathol. 2011;14:235-9 pubmed publisher
    ..Our report summarizes the case of a multifocal vulvar smooth muscle tumor of undetermined malignant potential with an unusual intravascular growth pattern and subsequent local ..
  3. Guntupalli S, Ramirez P, Anderson M, Milam M, Bodurka D, Malpica A. Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis. Gynecol Oncol. 2009;113:324-6 pubmed publisher
    This retrospective study was designed to evaluate the clinicopathologic features and outcomes of a cohort of patients diagnosed with uterine smooth muscle tumor of uncertain malignant potential (STUMP) seen at a single institution.
  4. Suankratay C. Images in HIV/AIDS. Epstein-Barr virus-associated smooth muscle tumor in a person with AIDS. AIDS Read. 2008;18:50-C3 pubmed
  5. Kefeli M, Yildiz L, Kaya F, Aydin O, Kandemir B. Fascin expression in uterine smooth muscle tumors. Int J Gynecol Pathol. 2009;28:328-33 pubmed publisher
    ..In this study, we compared fascin expression in cases of leiomyoma, leiomyoma variants (LVs), uterine smooth muscle tumor of uncertain malignant potential (STUMP), and LMS, and sought to determine the potential role of fascin in ..
  6. Saeed A, Hanaa B, Faisal A, Najla A. Cotyledonoid dissecting leiomyoma of the uterus: a case report of a benign uterine tumor with sarcomalike gross appearance and review of literature. Int J Gynecol Pathol. 2006;25:262-7 pubmed
    Cotyledonoid dissecting leiomyoma (Sternberg tumor) is a very rare variant of uterine smooth muscle tumor with an unusual and alarming gross appearance. Including our case, approximately 20 cases were reported in the literature...
  7. Rath Wolfson L, Rosenblat Y, Halpern M, Herbert M, Hammel I, Gal R, et al. A new scoring system using multiple immunohistochemical markers for diagnosis of uterine smooth muscle tumors. J Cell Mol Med. 2006;10:197-205 pubmed
  8. Mulayim N, Gucer F. Borderline smooth muscle tumors of the uterus. Obstet Gynecol Clin North Am. 2006;33:171-81 pubmed
    At present, decision regarding where to place a uterine smooth muscle tumor that deviates from the most obvious leiomyoma and leiomyosarcoma groups still depends on time-honored conventional criteria...
  9. Petersson F. Epstein-Barr virus-associated smooth muscle tumor-report of 3 tumors including 1 intracerebral case with a prominent intratumoral B-lymphocytic component and plasma cells. Ann Diagn Pathol. 2013;17:91-8 pubmed publisher
    ..The intracranial tumor was associated with prominent intracerebral edema and displayed, in addition to a prominent intratumoral T-cell component, a hitherto unreported component of prominent intratumoral B cells and plasma cells...
  10. Schwetye K, Pfeifer J, Duncavage E. MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors. Hum Pathol. 2014;45:65-70 pubmed publisher
    ..in pelvic/retroperitoneal sites (10/29); 0% of extrauterine leiomyomas (0/29); 8% of smooth muscle tumor of uncertain malignant potential (1/12); 30% of uterine leiomyosarcomas (6/20); and 4% of extrauterine ..
  11. Vivehanantha S, Browne F, Bowen C, Brundler M, Hughes J, Moss C, et al. A congenital smooth muscle hamartoma masquerading as a reticulate vascular naevus. Clin Exp Dermatol. 2013;38:751-3 pubmed publisher
    ..To our knowledge, SMH with linear configuration has only been described in two previous cases, and there are no previous reports of SMH with such a marked resemblance to a vascular lesion. ..
  12. Gokaslan H, Turkeri L, Kavak Z, Eren F, Sismanoglu A, Ilvan S, et al. Differential diagnosis of smooth muscle tumors utilizing p53, pTEN and Ki-67 expression with estrogen and progesterone receptors. Gynecol Obstet Invest. 2005;59:36-40 pubmed
    ..2457). The expression of Ki-67, p53 and progesterone receptors is promising in immunodifferentiation of smooth muscle tumors of the uterus with malignant potential. ..
  13. Esmaeilzadeh M, Tavakolli A, Safaei A. Recurrent intracardiac leiomyomatosis. Can J Cardiol. 2007;23:1085-6 pubmed
    ..Intracardiac leiomyomatosis should be considered in women who present with a cardiac mass in the right-sided chambers...
  14. Larbcharoensub N, Karnsombut P, Jatchavala J, Wasutit Y, Nitiyanant P. Primary hepatic clear cell myomelanocytic tumor. Case report and review of the literature. APMIS. 2007;115:1454-9 pubmed publisher
    ..Clinical and pathologic features with a brief review of the relevant literature for hepatic CCMMT as a variant of perivascular epithelioid cell tumor (PEComa) are discussed. ..
  15. Liang J, Wu L, Xiao H, Li N, Wang H, Cheng C, et al. Use of myocardin in the classification of mesenchymal tumors of the uterus. Int J Gynecol Pathol. 2010;29:55-62 pubmed publisher
    ..Our study indicates that the myocardin is expressed in normal and neoplastic uterine smooth muscle cells sensitively and that the evaluation of myocardin expression is useful in distinguishing SMTs from ESSs. ..
  16. Perez Montiel M, Plaza J, Dominguez Malagon H, Suster S. Differential expression of smooth muscle myosin, smooth muscle actin, h-caldesmon, and calponin in the diagnosis of myofibroblastic and smooth muscle lesions of skin and soft tissue. Am J Dermatopathol. 2006;28:105-11 pubmed
    ..This panel may additionally be of assistance in the diagnosis of myofibroblastic sarcoma. ..
  17. Shen Q, Feng W, Long M, Duan X, Jaijakul S, Arias C, et al. Multicentric hepatic EBV-associated smooth muscle tumors in an AIDS patient: a case report, investigation of mTOR activation and review of the literature. Int J Clin Exp Pathol. 2011;4:421-9 pubmed
    ..In addition, we provide a review of the literature on the clinicopathologic findings of hepatic EBV-SMT in adult AIDS patients, and discuss their biologies and possible therapeutic strategies. ..
  18. Medlicott S, Devlin S, Helmersen D, Yilmaz A, Mansoor A. Early post-transplant smooth muscle neoplasia of the colon presenting as diminutive polyps: a case complicating post-transplant lymphoproliferative disorder. Int J Surg Pathol. 2006;14:155-61 pubmed
    ..Endoscopic features of early PTSN, which in this case presented as diminutive polypoid lesions, have not been described previously. ..
  19. Haltas H, Bayrak R, Yenidunya S, Tevrizci H. Completely infarcted smooth muscle tumor of the placental membrane. J Obstet Gynaecol Res. 2013;39:864-7 pubmed publisher
    Non-trophoblastic tumor of the placenta is rare, and so is placental smooth muscle tumor. We report leiomyoma of the placental membrane, which was discovered on cesarean section...
  20. Onesti M, Maruccia M, Carella S, Rossi A, Soda G, Scuderi N. Subcutaneous angioleiomyoma of the nasal tip. Report of a rare case. In Vivo. 2012;26:1091-4 pubmed
    ..Obvious and disfiguring scars do not remain with this surgical approach. The patient had immediate and complete relief of her symptoms, the aesthetic result is very good and her satisfaction is complete...
  21. Schneider N, Strauss D, Smith M, Miah A, Zaidi S, Benson C, et al. The Adequacy of Core Biopsy in the Assessment of Smooth Muscle Neoplasms of Soft Tissues: Implications for Treatment and Prognosis. Am J Surg Pathol. 2017;41:923-931 pubmed publisher
    ..The grading of soft tissue smooth muscle tumor biopsies has a lower accuracy compared with other adult soft tissue sarcomas and should therefore be taken ..
  22. Miettinen M, Sarlomo Rikala M, Lasota J. Gastrointestinal stromal tumours. Ann Chir Gynaecol. 1998;87:278-81 pubmed
  23. Deyrup A, Lee V, Hill C, Cheuk W, Toh H, Kesavan S, et al. Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. Am J Surg Pathol. 2006;30:75-82 pubmed
    ..EBV-2 can transform smooth muscle cells, independent of the presence of the LMP1 deletion associated with greater virulence. ..
  24. Martin de las Mulas J, Rollon E, Millan Y, Ordas J, Carrasco L, Reymundo C. Perineal leiomyoma expressing steroidal hormone receptors in a queen. Vet Rec. 2002;150:578-9 pubmed
  25. Lax S. [Mesenchymal uterine tumors. Leiomyomas]. Pathologe. 2009;30:274-83 pubmed publisher
    ..The term smooth muscle tumor of uncertain malignant potential (STUMP) should be reserved for tumors with uncertainty regarding cell type,..
  26. Tai W, Chuah S, Lin J, Chen H, Huang H, Kuo C, et al. Colorectal mesenchymal tumors - from smooth muscle tumors to stromal tumors. Oncol Rep. 2008;20:1157-64 pubmed
    ..Fifty-three GIST and 22 smooth muscle tumor specimens were included from 1986 to 2007...
  27. Bonneau C, Thomassin Naggara I, Dechoux S, Cortez A, Darai E, Rouzier R. Value of ultrasonography and magnetic resonance imaging for the characterization of uterine mesenchymal tumors. Acta Obstet Gynecol Scand. 2014;93:261-8 pubmed publisher
    ..95. Simple criteria, such as single tumor, non-myometrial tumor, abnormal endometrium and age, should question the diagnosis of benign leiomyoma. MRI enhanced the sensitivity of detecting MMT/STUMP. ..
  28. Erlandson R, Klimstra D, Woodruff J. Subclassification of gastrointestinal stromal tumors based on evaluation by electron microscopy and immunohistochemistry. Ultrastruct Pathol. 1996;20:373-93 pubmed
    ..Despite their similar light microscopic appearance, GIST are phenotypically heterogeneous, requiring both ultrastructural and immunohistochemical studies for accurate characterization...
  29. Dundr P, Fischerova D, Povysil C, Cibula D, Zikan M. Myxoid mixed low-grade endometrial stromal sarcoma and smooth muscle tumor of the uterus. Case report. Cesk Patol. 2012;48:103-6 pubmed
    We report the case of a 73-year-old female with myxoid mixed low-grade endometrial stromal sarcoma and smooth muscle tumor of the uterus. Grossly, the tumor sized 130 x 130 x 100 mm involved the uterine corpus almost in its entirety...
  30. Kathuria K, Menon S, Deodhar K, Bakshi G, Desai S. Pelvic periprostatic symplastic leiomyoma: an unusual case necessitating a radical surgery. J Cancer Res Ther. 2013;9:299-301 pubmed publisher
    ..The diagnostic and treatment dilemmas of these unusual tumors are discussed. ..
  31. Ozler A, Evsen M, Turgut A, Sak M, Tunc S, Ağaçayak E, et al. CD147 expression in uterine smooth muscle tumors, and its potential role as a diagnostic and prognostic marker in patients with leiomyosarcoma. J Exp Ther Oncol. 2014;10:325-30 pubmed
    ..We investigated CD147 protein expression in uterine smooth muscle tumor samples from patients diagnosed with leiomyoma (n = 22), atypical leiomyoma (BLM) (n = 5), smooth muscle ..
  32. Bateman A, Holgate K, Green B, Thway K, Primrose J. Spindle cell tumour with glandular elements: an unusual ileal neoplasm. J Clin Pathol. 2009;62:555-7 pubmed publisher
    ..None of the characteristic mutations of GISTs were identified in this case. There were no overt features of malignancy but, because of the unusual nature of the case, we assessed the biological behaviour as uncertain. ..
  33. Vilos G, Marks J, Ettler H, Vilos A, Prefontaine M, Abu Rafea B. Uterine smooth muscle tumors of uncertain malignant potential: diagnostic challenges and therapeutic dilemmas. Report of 2 cases and review of the literature. J Minim Invasive Gynecol. 2012;19:288-95 pubmed publisher
    ..The clinical course of residual STUMP remains speculative. ..
  34. Thong J, Chuah K. EBV-associated smooth muscle tumour presenting as a parapharyngeal mass--a rare presentation. Auris Nasus Larynx. 2009;36:120-2 pubmed publisher
    ..We describe an interesting patient with an EBV-SMT which masqueraded as nasopharyngeal carcinoma, presenting with serous otitis media, nasopharyngeal mass and raised Epstein-Barr virus (EBV) serology. ..
  35. Sprangers B, Smets S, Sagaert X, Wozniak A, Wollants E, Van Ranst M, et al. Posttransplant Epstein-Barr virus-associated myogenic tumors: case report and review of the literature. Am J Transplant. 2008;8:253-8 pubmed publisher
    ..A case of a 51-year-old kidney transplant recipient diagnosed with EBV-SMT is reported together with a review of the literature. ..
  36. Mhanna T, Ranchere Vince D, Hervieu V, Tardieu D, Scoazec J, Partensky C. Clear cell myomelanocytic tumor (PEComa) of the duodenum in a child with a history of neuroblastoma. Arch Pathol Lab Med. 2005;129:1484-6 pubmed
  37. Siriudompas S, Klaitong C. Epstein-Barr Virus associated primary intracranial smooth muscle tumor in HIV positive patient: case report and review of the literature. J Med Assoc Thai. 2013;96:874-9 pubmed
    The authors report a case of HIV-positive patient with primary intracranial smooth muscle tumor Evidence of Epstein-Barr Virus (EB V) infection in this tumor is proven by in situ hybridization for EBV-encoded RNA (EBER)...
  38. Danielson L, Menendez S, Attolini C, Guijarro M, Bisogna M, Wei J, et al. A differentiation-based microRNA signature identifies leiomyosarcoma as a mesenchymal stem cell-related malignancy. Am J Pathol. 2010;177:908-17 pubmed publisher
    ..In summary, this work expands on our knowledge of the regulation of SM differentiation and sarcoma pathogenesis. ..
  39. Fadare O, Renshaw I, Liang S. Patterns of bone morphogenetic protein-2 expression in smooth muscle tumors of the uterine corpus and other uterine tissues. Appl Immunohistochem Mol Morphol. 2011;19:352-9 pubmed publisher
    ..BMP2 is rarely expressed in the other nonendothelial tissues of the human uterine corpus that were evaluated. The significance of frequent BMP2 expression in small vessels of the uterus requires further investigation. ..
  40. Can N, Grenert J, Vohra P. Concomitant Epstein-Barr Virus-associated smooth muscle tumor and granulomatous inflammation of the liver. Pathol Res Pract. 2017;213:1306-1309 pubmed publisher
    Epstein-Barr Virus-associated smooth muscle tumor (EBV-SMT) is a rare mesenchymal tumor typically seen in immunocompromised patients...
  41. Roth L, Kirker J, Insull M, Whittaker J. Recurrent cotyledonoid dissecting leiomyoma of the uterus. Int J Gynecol Pathol. 2013;32:215-20 pubmed publisher
    ..She was living and well 2.5 yr after hysterectomy with no evidence of disease...
  42. Kraft S, Fletcher C. Atypical intradermal smooth muscle neoplasms: clinicopathologic analysis of 84 cases and a reappraisal of cutaneous "leiomyosarcoma". Am J Surg Pathol. 2011;35:599-607 pubmed publisher
    ..On excision with clear margins, the risk of local recurrence is very low. Hence, we propose the term "atypical intradermal smooth muscle neoplasm" as being more appropriate...
  43. Wong K, Chan K, Lee S, Lai S, Lee N, Cockram C, et al. Epstein-Barr virus-associated smooth muscle tumor in patients with acquired immunodeficiency syndrome. J Microbiol Immunol Infect. 2007;40:173-7 pubmed
    Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is a recognized but uncommon disease that is found to occur in patients with immunocompromised conditions such as acquired immunodeficiency syndrome (AIDS)...
  44. Mathew M, Gowri V, al Hamdani A, Machado L, Rao K, Shabnam S. Cotyledonoid leiomyoma in pregnancy. Obstet Gynecol. 2007;109:509-11 pubmed
    ..Some variant forms with unusual infiltrative growth pattern have been known, but they are rare in pregnancy. The variant forms pose diagnostic and management difficulties...
  45. Zhuang H, Luo Y, Xu X, Peng T, Chen D, Teng F. [Primary smooth muscle tumor in the male reproductive system: a report of 5 cases and review of the literature]. Zhonghua Nan Ke Xue. 2013;19:714-8 pubmed
    To systematically study the clinical diagnosis and treatment of smooth muscle tumor in the male reproductive system.
  46. Calder K, Schlauder S, Morgan M. Malignant perivascular epithelioid cell tumor ('PEComa'): a case report and literature review of cutaneous/subcutaneous presentations. J Cutan Pathol. 2008;35:499-503 pubmed
  47. Wachter D, Thiel F, Hartmann A, Agaimy A. Epithelioid clear cell smooth muscle tumor of the ovary presenting as a mural nodule in an endometrioid adenocarcinoma with clear cell changes. Int J Gynecol Pathol. 2011;30:58-61 pubmed publisher
    ..To our knowledge, this case represents the first report of an ovarian epithelioid smooth muscle tumor presenting in this particular setting...
  48. Suwansirikul S, Sukpan K, Sittitrai P, Suwiwat S, Khunamornpong S. Epstein-Barr virus-associated smooth muscle tumor of the tonsil. Auris Nasus Larynx. 2012;39:329-32 pubmed publisher
    Smooth muscle tumors of the tonsil are rare. Recently, the occurrence of Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) has been increasingly recognized in immunocompromised patients, mainly post-transplantation and AIDS ..
  49. Fadare O, Renshaw I, Olson S, Liang S. The phosphatidylinositol 3' kinase-Akt-mammalian target of rapamycin pathway in smooth muscle tumors of the uterus: selected protein expression patterns and their clinicopathologic implications. Int J Gynecol Pathol. 2011;30:244-51 pubmed publisher
    ..If corroborated in other laboratories, the expression patterns of proteins in this pathway, especially pan-Akt, may be of diagnostic use...
  50. Samadi D, Chughtai B, Akhavan A, Guru K, Rehman J. Incidental seminal vesicle smooth muscle neoplasm of unknown malignancy following robotic-assisted laparoscopic prostatectomy. Can J Urol. 2008;15:4109-11 pubmed
    ..To our knowledge, this is also the first report of a primary seminal vesicle tumor found following radical prostatectomy. A clinical case review and a brief review of the literature are presented...
  51. Pan C, Jong Y, Chai C, Huang S, Chen Y. Comparative genomic hybridization study of perivascular epithelioid cell tumor: molecular genetic evidence of perivascular epithelioid cell tumor as a distinctive neoplasm. Hum Pathol. 2006;37:606-12 pubmed
    ..From a molecular genetic perspective, the recurrent chromosomal alterations in both renal and extrarenal tumors further support the concept of PEComa as a distinctive tumor entity regardless of anatomic location...
  52. Handra Luca A, Nahon P, Flejou J, Molas G, Dubois S, Sauvanet A, et al. [Immunohistochemical and ultrastructural heterogeneity of gastrointestinal stromal tumors]. Gastroenterol Clin Biol. 2001;25:664-8 pubmed
    ..Sixteen tumors were analyzed on electron microscopy...
  53. Bodner K, Bodner Adler B, Kimberger O, Czerwenka K, Mayerhofer K. Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. J Soc Gynecol Investig. 2004;11:187-91 pubmed
    ..Furthermore, the correlation between bcl-2 expression and various clinicopathologic parameters in leiomyosarcomas was assessed to evaluate its prognostic value...
  54. Esposito N, Hunt J, Bakker A, Jones M. Analysis of allelic loss as an adjuvant tool in evaluation of malignancy in uterine smooth muscle tumors. Am J Surg Pathol. 2006;30:97-103 pubmed
    ..Molecular profiling may thus provide a valuable tool in assessment of malignancy in uterine smooth muscle tumors. Additionally, NM-23 is a promising candidate gene for determination of metastatic potential in these tumors...
  55. Weiss S. Smooth muscle tumors of soft tissue. Adv Anat Pathol. 2002;9:351-9 pubmed
    ..Their behavior is closely tied to the immune status of the patient rather than to specific histologic features...
  56. Ip P, Cheung A. Pathology of uterine leiomyosarcomas and smooth muscle tumours of uncertain malignant potential. Best Pract Res Clin Obstet Gynaecol. 2011;25:691-704 pubmed publisher
    ..The problems with histologic diagnosis, immunohistochemical studies and molecular pathology are reviewed...
  57. Ma S, Zhang H, Wu L, Liu L, Li B. [Border-line smooth-muscle tumor of the uterus: analysis of 131 patients]. Zhonghua Zhong Liu Za Zhi. 2005;27:698-700 pubmed
    ..To investigate whether the border-line uterine smooth-muscle tumor is different from leiomyoma or leiomyosarcoma in history and clinical manifestations...
  58. Zamecnik M, Sultani K. Meningothelial-like nodules: additional pattern of myoid differentiation in endometrial stromal tumors. Pathol Int. 2007;57:632-3 pubmed
  59. Nur S, Rosenblum W, Katta U, Islam H, Brown K, Ramaswamy G. Epstein-Barr virus-associated multifocal leiomyosarcomas arising in a cardiac transplant recipient: autopsy case report and review of the literature. J Heart Lung Transplant. 2007;26:944-52 pubmed
  60. Wang X, Tang W, Yu P. [Histological and immunohistochemical study and AgNOR analysis of smooth muscle tumors of the digestive tract]. Zhonghua Zhong Liu Za Zhi. 1994;16:128-31 pubmed
    ..Immunohistochemical studies of Vim, Des, S100, FN and Cyt revealed that none of them was very helpful in the differential diagnosis of LM from LS...
  61. Vaquero M, Magrina J, Leslie K. Uterine smooth-muscle tumors with unusual growth patterns. J Minim Invasive Gynecol. 2009;16:263-8 pubmed publisher
    ..We present a review of the recent literature along with the clinical and pathologic features of 5 illustrative cases from Mayo Clinic Arizona, Scottsdale...
  62. Boudjemaa S, Boman F, Guigonis V, Boccon Gibod L. Brain involvement in multicentric Epstein-Barr virus-associated smooth muscle tumours in a child after kidney transplantation. Virchows Arch. 2004;444:387-91 pubmed
    ..The immunosuppressive therapy was reduced, and the child was treated with chemotherapy, but died 2 months later, due to neurological complications...
  63. Bodner Adler B, Bodner K, Czerwenka K, Kimberger O, Leodolter S, Mayerhofer K. Expression of p16 protein in patients with uterine smooth muscle tumors: an immunohistochemical analysis. Gynecol Oncol. 2005;96:62-6 pubmed
    ..In the present study, we compared the expression of p16 protein in cases with leiomyoma, uterine smooth muscle tumor of uncertain malignant potential (STUMP), and leiomyosarcoma (LMS).
  64. de Graaff M, Cleton Jansen A, Szuhai K, Bovee J. Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity. Hum Pathol. 2013;44:1597-604 pubmed publisher
    ..The lack of mediator complex subunit 12 mutations in extrauterine leiomyomas and leiomyosarcomas indicates that these tumors arise through a different pathway, emphasizing the genetic heterogeneity of smooth muscle tumors. ..
  65. Tan C, Loh H, Foo M, Choong L, Wong K, Kee T. Epstein-Barr virus-associated smooth muscle tumors after kidney transplantation: treatment and outcomes in a single center. Clin Transplant. 2013;27:E462-8 pubmed publisher
    ..The aims of this study are to document the clinical features, types of treatment given, and outcomes of KTR with EBV SMT in our institution...
  66. Husamaldin Z, Aung W, McFerran D. Smooth muscle tumour of the pharynx: a rare tumour presenting with globus pharyngeus symptoms. J Laryngol Otol. 2004;118:885-7 pubmed
    ..The importance of mirror or endoscopic examination of the pharynx is stressed in patients with globus pharyngeus symptoms...
  67. Clauss S, Holler S, Hegi L, Blum R, Hösli I. ["STUMP" (smooth muscle tumour of uncertain malignant potential), a tumour of the uterus in pregnancy--a diagnostic and therapeutic challenge]. Z Geburtshilfe Neonatol. 2010;214:74-7 pubmed publisher
    ..We present the first description of a case of STUMP during pregnancy, raising the question of whether the histological finding in tumours of the uterus during pregnancy are important...
  68. Gibault L, Ferreira C, Pérot G, Audebourg A, Chibon F, Bonnin S, et al. From PTEN loss of expression to RICTOR role in smooth muscle differentiation: complex involvement of the mTOR pathway in leiomyosarcomas and pleomorphic sarcomas. Mod Pathol. 2012;25:197-211 pubmed publisher
    ..As therapeutics directed against the mTOR pathway are assessed in sarcomas, RICTOR overexpression in sarcomas and its links to therapeutic response need to be assessed...
  69. Rahemtullah A, Szyfelbein K, Zembowicz A. Glomus coccygeum: report of a case and review of the literature. Am J Dermatopathol. 2005;27:497-9 pubmed
    ..Recognition of the histologic features of glomus coccygeum is important to avoid confusion with glomus tumor and neural or smooth muscle neoplasms in the sacral area...
  70. Ravegnini G, Mariño Enríquez A, Slater J, Eilers G, Wang Y, Zhu M, et al. MED12 mutations in leiomyosarcoma and extrauterine leiomyoma. Mod Pathol. 2013;26:743-9 pubmed publisher
    ..These findings indicate that MED12 has oncogenic roles in a broad range of smooth muscle neoplasia, including tumors arising in extrauterine locations...
  71. Murakami M, Uehara H, Nishimura M, Iwasa T, Ikawa H. A huge ovarian smooth muscle tumor: a case report. J Med Invest. 2010;57:158-62 pubmed
    ..In this paper, we report the case of a 62-year-old woman who had a huge smooth muscle tumor of the right ovary. The values of all the serum tumor markers were within normal limit...
  72. Lin G, Yang L, Huang Y, Ng K, Ng S, Ueng S, et al. Comparison of the diagnostic accuracy of contrast-enhanced MRI and diffusion-weighted MRI in the differentiation between uterine leiomyosarcoma / smooth muscle tumor with uncertain malignant potential and benign leiomyoma. J Magn Reson Imaging. 2016;43:333-42 pubmed publisher
    ..contrast-enhanced (CE) magnetic resonance imaging (MRI) and diffusion-weighted MRI (DWI) in the differentiation between uterine leiomyosarcoma (LMS) / smooth muscle tumor with uncertain malignant potential (STUMP) and benign leiomyoma.
  73. Coco D, Hirsch M, Hornick J. Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract. Am J Surg Pathol. 2009;33:1795-801 pubmed
  74. Cohen D, Oliva E, Hahn P, Fuller A, Lee S. Uterine smooth-muscle tumors with unusual growth patterns: imaging with pathologic correlation. AJR Am J Roentgenol. 2007;188:246-55 pubmed
    ..Finally, we highlight the role of the radiologist in triaging these patients to surgical versus medical management and in surgical planning...
  75. Yu L, Aldave A, Glasgow B. Epstein-Barr virus-associated smooth muscle tumor of the iris in a patient with transplant: a case report and review of the literature. Arch Pathol Lab Med. 2009;133:1238-41 pubmed publisher
    ..Incisional biopsy of the mass revealed a smooth muscle tumor of the iris...
  76. Gezginc K, Yazici F, Tavli L. Uterine smooth muscle tumors of uncertain malignant potential: a case presentation. Int J Clin Oncol. 2011;16:592-5 pubmed publisher
    ..Our case was diagnosed as uterine smooth muscle tumor of uncertain malignant potential (STUMP)...
  77. Parikh P, Chan T, Epstein J, Argani P. Incidental stromal-predominant mixed epithelial-stromal tumors of the kidney: a mimic of intraparenchymal renal leiomyoma. Arch Pathol Lab Med. 2005;129:910-4 pubmed
    ..The recognized morphologic spectrum of this recently described entity is evolving...
  78. Shintaku M, Hashimoto H. Mixed endometrial stromal and smooth muscle tumor: report of a case with focal anaplasia and early postoperative lung metastasis. Pathol Int. 2013;63:214-9 pubmed publisher
    A rare case of a mixed endometrial stromal and smooth muscle tumor arising in the uterus of a 74-year-old woman is reported...
  79. Raspollini M, Amunni G, Villanucci A, Boddi V, Simoni A, Taddei A, et al. Estrogen and progesterone receptors expression in uterine malignant smooth muscle tumors: correlation with clinical outcome. J Chemother. 2003;15:596-602 pubmed
    ..006 and P=0.016, respectively), PR expression (P=0.005 and P=0.016, respectively), and FIGO stage disease (P=0.011 and P=0.007, respectively) were independent predictors of the risk of recurrence and death from disease...
  80. Amant F, Moerman P, Vergote I. Report of an unusual problematic uterine smooth muscle neoplasm, emphasizing the prognostic importance of coagulative tumor cell necrosis. Int J Gynecol Cancer. 2005;15:1210-2 pubmed
    ..This case adds to the limited experience of the clinical behavior of problematic uterine smooth muscle cell neoplasms and underscores the prognostic importance of CTCN...
  81. Solomon L, Schimp V, Ali Fehmi R, Diamond M, Munkarah A. Clinical update of smooth muscle tumors of the uterus. J Minim Invasive Gynecol. 2005;12:401-8 pubmed
    ..The goal of this review is to present the most recent information about common smooth muscle tumors of the uterus including their etiology, histopathology, radiographic and clinical presentations, and available treatment options...
  82. Hall B, Grossmann A, Webber N, Ward R, Tripp S, Rosenthal H, et al. Atypical intradermal smooth muscle neoplasms (formerly cutaneous leiomyosarcomas): case series, immunohistochemical profile and review of the literature. Appl Immunohistochem Mol Morphol. 2013;21:132-8 pubmed publisher
    ..Although the significance of frequent PTEN loss supports a molecular mechanism of tumor genesis, the diagnostic utility of the stain remains to be determined...
  83. Bal A, Joshi K, Vaiphei K, Wig J. Primary duodenal neoplasms: a retrospective clinico-pathological analysis. World J Gastroenterol. 2007;13:1108-11 pubmed
    ..To analyze the clinico-pathological spectrum of primary duodenal neoplasms...
  84. Ng J, Han A, Chew S, Low J. A clinicopathologic study of uterine smooth muscle tumours of uncertain malignant potential (STUMP). Ann Acad Med Singapore. 2010;39:625-8 pubmed
    ..The objective of this study was to review a single institution's experience with STUMP and recommend a rational clinical approach to the management of patients with this histological diagnosis...
  85. Mozzachio K, Linder K, Dixon D. Uterine smooth muscle tumors in potbellied pigs (Sus scrofa) resemble human fibroids: a potential animal model. Toxicol Pathol. 2004;32:402-7 pubmed
    ..These results support further investigation of uterine leiomyomas in potbellied pigs as a potentially valuable animal model for studying human fibroids...
  86. Comunoğlu N, Durak H, Comunoglu C, Ekici A, Ozkan F, Akyildiz E, et al. Expression of cyclooxygenase-2, c-kit, progesterone and estrogen receptors in uterine smooth muscle tumors: differential diagnosis. APMIS. 2007;115:726-35 pubmed
    ..LMSs usually do not express COX-2. COX-2 expression in smooth muscle tumors is not a prominent feature. Therefore, COX-2 inhibitors may not be useful in LMS therapy. C-kit was significantly expressed in uterine LMSs...
  87. Ip P, Cheung A, Clement P. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 2009;33:992-1005 pubmed publisher
    The current World Health Organization classification indicates that a uterine smooth muscle tumor that cannot be histologically diagnosed as unequivocally benign or malignant should be termed "smooth muscle tumor of uncertain ..
  88. Dei Tos A, Wagner A, Modena P, Comandone A, Leyvraz S. Epithelioid soft tissue tumors. Semin Oncol. 2009;36:347-57 pubmed publisher
    ..Some of these tumors provide excellent opportunities to examine newer protein-targeted agents in investigational settings...
  89. Prayson R, Hart W. Pathologic considerations of uterine smooth muscle tumors. Obstet Gynecol Clin North Am. 1995;22:637-57 pubmed
    ..Individual features, such as hypercellularity, necrosis, nuclear atypia, mitotic figures, and intravascular growth, are ominous but must be interpreted with caution because variants of benign leiomyoma may contain such changes...