neurothekeoma

Summary

Summary: A benign myxoma of cutaneous nerve sheath origin. Theke is from the Greek theke, sheath. (From Stedman, 25th ed)

Top Publications

  1. Rudolph P, Schubert C. Myxoid cellular neurothekeoma. Am J Dermatopathol. 2002;24:92-3 pubmed
  2. Bhaskar A, Kanvinde R. Neurothekeoma of the hand. J Hand Surg Br. 1999;24:631-3 pubmed
    ..We report an unusual case of a neurothekeoma involving the hand. Histological examination revealed characteristic myxoid nodules with spindle shaped cells...
  3. Portnof J, Friedman J, Reich R, Freedman P, Behrman D. Oral ectomesenchymal chondromyxoid tumor: case report and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:e20-4 pubmed publisher
    ..It is important for clinicians to have a better understanding of ECMT, so as to avoid future misdiagnosis of this entity...
  4. Hornick J, Fletcher C. Cellular neurothekeoma: detailed characterization in a series of 133 cases. Am J Surg Pathol. 2007;31:329-40 pubmed
    ..In 30% of cases, neurothekeoma was suggested by the referring pathologist; the most common other diagnoses offered were plexiform ..
  5. Yamada S, Kitada S, Nabeshima A, Noguchi H, Sasaguri Y, Hisaoka M. Benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma arising from the nose. Diagn Pathol. 2013;8:165 pubmed publisher
    ..of a benign cutaneous plexiform nerve sheath tumor with hybrid characteristics of perineurioma and cellular neurothekeoma, given the name as a benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma, all ..
  6. Misra R. Neurothekeoma palpebrae. Plast Reconstr Surg. 2004;114:1975-6 pubmed
  7. Marocchio L, Oliveira D, Consolaro A. Myxoid neurothekeoma of the oral mucosa: an unusual benign tumor. Oral Dis. 2004;10:408-9 pubmed
  8. Vered M, Fridman E, Carpenter W, Buchner A. Classic neurothekeoma (nerve sheath myxoma) and cellular neurothekeoma of the oral mucosa: immunohistochemical profiles. J Oral Pathol Med. 2011;40:174-80 pubmed publisher
    Classic neurothekeoma (nerve sheath myxoma) is regarded as being a true benign cutaneous tumor of nerve sheath origin. Cellular neurothekeoma was separated from the classic type by histogenesis, morphology and immunophenotype...
  9. Requena L, Sitthinamsuwan P, Fried I, Kaddu S, Schirren C, Schärer L, et al. A benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma. Am J Surg Pathol. 2013;37:845-52 pubmed publisher
    ..plexiform nerve sheath tumor located on the lips and exhibiting hybrid features of perineurioma and cellular neurothekeoma. Clinically, lesions were solitary dome-shaped papules located on the lips...

More Information

Publications62

  1. Fullen D, Lowe L, Su L. Antibody to S100a6 protein is a sensitive immunohistochemical marker for neurothekeoma. J Cutan Pathol. 2003;30:118-22 pubmed
    b>Neurothekeoma is a benign tumor of putative peripheral nerve sheath origin. It occurs in a myxoid (classic) variant, cellular variant, and intermediate (mixed) variant...
  2. Zedek D, White W, McCalmont T. Desmoplastic cellular neurothekeoma: Clinicopathological analysis of twelve cases. J Cutan Pathol. 2009;36:1185-90 pubmed publisher
    Cellular neurothekeoma is a benign lesion most commonly found on the face and upper extremities in the first two decades of life.
  3. Papadopoulos E, Cohen P, Hebert A. Neurothekeoma: report of a case in an infant and review of the literature. J Am Acad Dermatol. 2004;50:129-34 pubmed
    ..We describe an infant with a neurothekeoma and review the literature of neurothekeomas in children and adults...
  4. Nishioka M, Aguirre R, Ishikawa A, Nagumo K, Wang L, Okada N. Nerve sheath myxoma (neurothekeoma) arising in the oral cavity: histological and immunohistochemical features of 3 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:e28-33 pubmed publisher
    ..describes the histological and immunohistochemical characteristics of 3 cases of nerve sheath myxoma (NSM)/neurothekeoma arising in the oral cavity...
  5. Kakizaki H, Zako M, Iwaki M, Mito H. Successful percutaneous incision and pathological examination of a rare nerve sheath myxoma: diagnosis and treatment. Jpn J Ophthalmol. 2004;48:78-79 pubmed
  6. Fox M, Billings S, Gleason B, Moore J, Thomas A, Shea C, et al. Expression of MiTF may be helpful in differentiating cellular neurothekeoma from plexiform fibrohistiocytic tumor (histiocytoid predominant) in a partial biopsy specimen. Am J Dermatopathol. 2012;34:157-60 pubmed publisher
    Overlapping histopathologic features of cellular neurothekeoma (CNT) and plexiform fibrohistiocytic tumor (PFHT), when both are predominantly composed of histiocytoid cells, make distinction between these entities challenging...
  7. Fetsch J, Laskin W, Hallman J, Lupton G, Miettinen M. Neurothekeoma: an analysis of 178 tumors with detailed immunohistochemical data and long-term patient follow-up information. Am J Surg Pathol. 2007;31:1103-14 pubmed
    ..An origin from fibroblastic cells with the ability to differentiate into myofibroblasts and a tendency to recruit histiocytic cells is postulated...
  8. García Gutiérrez M, Toussaint Caire S, González Sánchez P, Ortiz Hidalgo C. Multiple desmoplastic cellular neurothekeomas localized to the face of a 16-year-old boy. Am J Dermatopathol. 2010;32:841-5 pubmed
    ..5, and factor XIIIa and were negative for CD68, glial fibrillary acid protein (GFAP), S-100, HMB-45, epithelial membrane antigen, actin, and CD57 consistent with a diagnosis of multiple desmoplastic cellular neurothekeomas...
  9. Safadi R, Hellstein J, Diab M, Hammad H. Nerve sheath myxoma (neurothekeoma) of the gingiva, a case report and review of the literature. Head Neck Pathol. 2010;4:242-5 pubmed publisher
    ..In this report, we describe the first gingival case of oral neurothekeoma with histopathologic and immunohistochemical characteristics...
  10. Cohen N, Samadi D, Pawel B, Kazahaya K. Cellular neurothekeoma of the maxilla. Ann Otol Rhinol Laryngol. 2004;113:384-7 pubmed
    ..An incisional biopsy resulted in the diagnosis of neurothekeoma. This lesion should be considered as part of the differential diagnosis of pediatric soft tissue head and neck ..
  11. Trotot Voilliot C, Laveine E, Beurey P, Cuny J, Schmutz J, Truchetet F. [A case of primary cutaneous PEComa]. Ann Dermatol Venereol. 2013;140:373-7 pubmed publisher
    ..PEComas (PEC: Perivascular epithelioid cell) are tumours expressing both melanocytic and myogenic markers. The clinical features are non-specific...
  12. Pal L, Bansal K, Behari S, Sagar B, Gupta R, Shankar S. Intracranial neurothekeoma--a rare parenchymal nerve sheath myxoma of the middle cranial fossa. Clin Neuropathol. 2002;21:47-51 pubmed
    ..We report here the first case of neurothekeoma located deep inside the brain parenchyma...
  13. Wong B, Hui Y, Lam K, Wei W. Neurothekeoma of the paranasal sinuses in a 3-year-old boy. Int J Pediatr Otorhinolaryngol. 2002;62:69-73 pubmed
    b>Neurothekeoma is a benign soft tissue tumor commonly located on the skin. In this report, a 3-year-old boy presented with restricted right eye movement and decrease in visual acuity...
  14. Yeh I, Tran D, Davis T, Argenyi Z. An infiltrative variant of non-neural granular cell tumor: a case report. J Cutan Pathol. 2009;36 Suppl 1:46-51 pubmed publisher
    ..Our case could represent a dermal non-neural granular cell tumor with unique architecture, a granular cellular neurothekeoma or a granular cell dermatofibroma...
  15. Papalas J, Proia A, Hitchcock M, Gandhi P, Cummings T. Neurothekeoma palpebrae: A report of 3 cases. Am J Dermatopathol. 2010;32:374-9 pubmed
    b>Neurothekeoma palpebrae is the diagnostic term used to describe nerve sheath myxoma or neurothekeoma of the eyelid. Although these tumors are not uncommonly found in the head and neck region, eyelid involvement is very uncommon...
  16. Plaza J, Torres Cabala C, Evans H, Diwan A, Prieto V. Immunohistochemical expression of S100A6 in cellular neurothekeoma: clinicopathologic and immunohistochemical analysis of 31 cases. Am J Dermatopathol. 2009;31:419-22 pubmed publisher
    b>Neurothekeoma is a term introduced by Gallager and Helwig describing a superficial tumor of purported nerve sheath derivation, with cellular and myxoid types...
  17. Thakral B, Gleason B, Thomas A, Billings S, Victor T, Cibull T. Cellular neurothekeoma with fascicular growth features mimicking cellular dermatofibroma. Am J Dermatopathol. 2011;33:281-4 pubmed publisher
    Cellular neurothekeoma (CNT) is a benign cutaneous mesenchymal neoplasm. Most demonstrate a lobulated to micronodular architecture...
  18. Jaffer S, Ambrosini Spaltro A, Mancini A, Eusebi V, Rosai J. Neurothekeoma and plexiform fibrohistiocytic tumor: mere histologic resemblance or histogenetic relationship?. Am J Surg Pathol. 2009;33:905-13 pubmed publisher
    b>Neurothekeoma (NTK) and plexiform fibrohistiocytic tumor (PFHT) are dermal neoplasms that share many clinical and histologic features and whose histogenesis is equally disputed...
  19. Aydingöz I, Mansur A, Dikicioğlu Çetin E. Arborizing vessels under dermoscopy: a case of cellular neurothekeoma instead of basal cell carcinoma. Dermatol Online J. 2013;19:5 pubmed
    b>Neurothekeoma is a slow-growing, benign tumor of nerve sheath origin. Herein we present a 62-year-old female who presented with a 5-month history of a nodule that had shown a slight enlargement...
  20. Hanrahan J, Wills M, Frost J, Winter S, Lawrence J, Mathew P. Cellular neurothekeoma of the chest wall. Med Pediatr Oncol. 2002;39:134-6 pubmed
  21. Ward J, Prieto V, Joseph A, Chevray P, Kronowitz S, Sturgis E. Neurothekeoma. Otolaryngol Head Neck Surg. 2005;132:86-9 pubmed
    The purpose of this study was to investigate and share the experiences at The University of Texas M. D. Anderson Cancer Center in diagnosing, treating, and following patients with neurothekeoma. We report 13 cases.
  22. Ekşi E, Oztop I. Nerve sheath myxoma of the upper lip: a case report. Kulak Burun Bogaz Ihtis Derg. 2010;20:318-20 pubmed
    ..Although very rare, nerve sheath myxoma should be considered in the differential diagnosis of lip mass and widely excised to avoid local recurrence. The patient is under clinical control with no signs of recurrence after 16 months...
  23. Linos K, Stuart L, Goncharuk V, Edgar M. Benign cutaneous biphasic hybrid tumor of perineurioma and cellular neurothekeoma: A case report expanding the clinical and histopathologic features of a recently described entity. Am J Dermatopathol. 2015;37:319-22 pubmed
    Benign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma (BCPHTPCN) is a recently described entity that presents as a solitary papule in the perioral area...
  24. Makino T, Utsunomiya T, Kamino Y, Kobayashi R, Fukumoto M, Yamamoto H, et al. Nerve sheath myxoma of the tongue in a child. Int J Oral Maxillofac Surg. 2002;31:451-4 pubmed
    ..Immunohistochemically, the tumour cells were strongly positive for S-100 beta protein and neuron-specific enolase. These results suggested that the tumour originated from Schwann cells...
  25. Vincent A, Farley M, Chan E, James W. Birt-Hogg-Dubé syndrome: two patients with neural tissue tumors. J Am Acad Dermatol. 2003;49:717-9 pubmed
    We present 2 unrelated patients found to have tumors of neural tissue origin, a neurothekeoma and a meningioma, who were additionally diagnosed with the syndrome of Birt-Hogg-Dubé (BHDS)...
  26. Alexandru D, Satyadev R, So W. Neurothekeoma in the posterior fossa: case report and literature review. Perm J. 2012;16:63-4 pubmed
    b>Neurothekeoma is a benign nerve sheath tumor, also known as nerve sheath myxoma. It arises from the cutaneous nerves of the head and neck region...
  27. Padgett S, Walsh S, Kory M, Argenyi Z. Agminated cellular neurothekeoma. J Cutan Pathol. 2011;38:990-3 pubmed publisher
    Cellular neurothekeoma represents a benign, slow-growing neoplasm that typically occurs as a solitary lesion on the face, neck or arm. Reports of multiple lesions are rare...
  28. Avninder S, Ramesh V, Vermani S. Benign nerve sheath myxoma (myxoid neurothekeoma) in the leg. Dermatol Online J. 2007;13:14 pubmed
    Myxoid neurothekeoma is a rare benign cutaneous neoplasm of nerve sheath origin and is also called as benign nerve sheath myxoma. This entity is seen in head, neck and upper extremity and seldom on the lower limb...
  29. Connolly M, Hickey J, Intzedy L, Pawade J, de Berker D. Subungual neurothekeoma. J Am Acad Dermatol. 2005;52:159-62 pubmed
    ..To our knowledge, this is the first case of a subungual neurothekeoma affecting the big toe...
  30. Clark F, Somoano B, Taube J, Egbert B, Kim J. Eyebrow papule in an elderly man. Dermatol Online J. 2009;15:14 pubmed
    ..The lesional cells were NKI/C3-positive and S-100-negative. A diagnosis of cellular neurothekeoma was made.
  31. Yang Y, Shih I, Huang Y, Kuo T, Hong H. Mixed-type neurothekeoma presenting with an unusual clinical appearance of multiple satellite lesions on the back. Dermatol Surg. 2005;31:720-2 pubmed
    b>Neurothekeoma is a rare cutaneous neoplasm, often occurring as a nondescript cutaneous nodule on the central face, shoulders, and upper extremities.
  32. Krathen R, Donnelly H. Re: Mohs micrographic surgery for cellular neurothekeoma with atypia. Dermatol Surg. 2008;34:428 pubmed publisher
  33. Kim H, Baek C, Ko Y, Choi J. Neurothekeoma of the tongue: CT, MR, and FDG PET imaging findings. AJNR Am J Neuroradiol. 2006;27:1823-5 pubmed
    ..CT, MR, and fluorodeoxyglucose-positron-emission tomography (FDG-PET) imaging findings of a case of cellular neurothekeoma of the tongue, a rare benign soft-tissue tumor with neural differentiation, occurring in a 15-year-old girl...
  34. Wollina U, Hansel G, Schönlebe J, Haroske G. Myxoid neurothekeoma--a painful case in a less common location. Dermatol Online J. 2009;15:3 pubmed
    Myxoid neurothekeoma is a rare benign asymptomatic tumor of the skin. Most tumors are located on the head, shoulders and arms. We present a 19-year-old female patient with a relapsing tumor of this type in a less common localization, i.e...
  35. Lane J, Mullins S, Davis L. Clinical pathologic challenge. Cellular neurothekeoma. Am J Dermatopathol. 2006;28:65-6; answer and discussion 87-8 pubmed
  36. García Gutiérrez M, Toussaint Caire S, González Sánchez P, Ortiz Hidalgo C. Multiple desmoplastic cellular neurothekeomas localized to the face of a 16-year-old boy. Am J Dermatopathol. 2010;32:509-13 pubmed publisher
    ..5, and factor XIIIa and were negative for CD68, glial fibrillary acid protein (GFAP), S-100, HMB-45, epithelial membrane antigen, actin, and CD57 consistent with a diagnosis of multiple desmoplastic cellular neurothekeomas...
  37. Walsh S, Sangueza O. Ossifying plexiform tumor: report of two new cases. Am J Dermatopathol. 2008;30:73-6 pubmed publisher
    Ossifying plexiform tumor is a cutaneous lesion that microscopically resembles cellular neurothekeoma but has abundant central ossification as the prominent feature and has only been previously described in a single case report...
  38. SUAREZ A, High W. Immunohistochemical analysis of KBA.62 in 18 neurothekeomas: a potential marker for differentiating neurothekeoma, but a marker that may lead to confusion with melanocytic tumors. J Cutan Pathol. 2014;41:36-41 pubmed publisher
    b>Neurothekeoma represents a neoplasm of uncertain histogenesis that often occurs on the head and neck of younger individuals...
  39. Peters G, Wentzell M. Cellular neurothekeoma treated with Mohs micrographic surgery. Dermatol Surg. 2007;33:239-44 pubmed
  40. Page R, King R, Mihm M, Googe P. Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma. Mod Pathol. 2004;17:230-4 pubmed
    While the usual or myxoid-type neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular neurothekeoma remains in disputed histogenesis...
  41. Sánchez Orgaz M, Grabowska A, Arbizu Duralde A, Romero Martín R, Patrón M, Diéguez E, et al. Orbital nerve sheath myxoma: a case report. Ophthalmic Plast Reconstr Surg. 2011;27:e106-8 pubmed publisher
    ..This is the first case reported in the literature of such a tumor located in the orbit, and, though extremely rare, it should be considered in the differential diagnosis of orbital tumors. ..
  42. D Antonio A, Cuomo R, Angrisani B, Addesso M, Angrisani P. Cellular neurothekeoma with neuroendocrine differentiation. Dermatol Online J. 2011;17:2 pubmed
    We report a case of cellular neurothekeoma with unusual clinicopathological features in which neuroendocrine markers, determined by immunohistochemistry were observed...
  43. Mertz K, Mentzel T, Grob M, Pfaltz M, Kempf W. A rare case of atypical cellular neurothekeoma in a 68-year-old woman. J Cutan Pathol. 2009;36:1210-4 pubmed publisher
    Cellular neurothekeoma is a benign dermal lesion of uncertain differentiation...
  44. AlGhamdi K, Al Mubarak L. A myxoid neurothekeoma of the nose. J Drugs Dermatol. 2012;11:252-5 pubmed
    b>Neurothekeoma is a rare neoplasm assigned to the broad category of benign peripheral nerve sheath tumors...
  45. Persich G, Portela M. Neurothekeoma in the foot: a rare occurrence. J Am Podiatr Med Assoc. 2004;94:59-60 pubmed
    b>Neurothekeoma is a benign cutaneous neoplasm of nerve sheath origin. This seldom-seen entity is especially rare in the foot...
  46. Misago N, Satoh T, Narisawa Y. Cellular neurothekeoma with histiocytic differentiation. J Cutan Pathol. 2004;31:568-72 pubmed
    It is generally accepted that the two types of neurothekeoma (myxoid type and cellular type) represent the two poles of a spectrum...
  47. Mohmand M, Yap L, Morris A. Neurothekeoma in a burned extremity. Plast Reconstr Surg. 2002;110:1186-7 pubmed
  48. Cribier B, Baran R, Varini J. [Nerve sheath myxoma of the hyponychium]. Ann Dermatol Venereol. 2013;140:535-9 pubmed publisher
    Nerve sheath myxoma is a rare benign tumour of the extremities that was long confounded with neurothekeoma. Herein, we describe a rare case of interest because of its site on the hyponychium.
  49. Benbenisty K, Andea A, Metcalf J, Cook J. Atypical cellular neurothekeoma treated with Mohs micrographic surgery. Dermatol Surg. 2006;32:582-7; discussion 587 pubmed
    Atypical cellular neurothekeoma is a rare neoplasm generally regarded as a benign tumor with locally aggressive behavior. Recurrence is common with inadequate excision, but metastatic disease has yet to be reported.
  50. O Rourke H, Meyers S, Katzman P. Neurothekeoma in the upper extremity: magnetic resonance imaging and computed tomography findings. J Comput Assist Tomogr. 2005;29:847-50 pubmed
    ..This report describes the magnetic resonance imaging and computed tomography features of a neurothekeoma in the left forearm of a 38-year-old woman with a 2-year history of a painful mass...
  51. Seo B, Kang H, Lee J, Kwon H, Jung S. Ankle neurothekeoma: a case report. J Foot Ankle Surg. 2013;52:678-80 pubmed publisher
    b>Neurothekeoma is a rare, benign, cutaneous tumor of nerve sheath origin that is also termed benign nerve sheath myxoma. This tumor is usually asymptomatic and grows slowly...
  52. Wartchow E, Goin L, Schreiber J, Mierau G, Terella A, Allen G. Plexiform fibrohistiocytic tumor: ultrastructural studies may aid in discrimination from cellular neurothekeoma. Ultrastruct Pathol. 2009;33:286-92 pubmed publisher
    ..malignancy that can at times be difficult to differentiate from the less biologically aggressive cellular neurothekeoma. The two entities, which may display identical clinical and histological features, cannot be distinguished by ..
  53. Akhtar S, Coldewey J, Timmons M. Cellular neurothekeoma in the arm of a child. Br J Plast Surg. 2004;57:572-4 pubmed
    Soft tissue tumours of the limb in children are uncommon. We report a cellular neurothekeoma, which presented as a hard, irregular tumour in the upper arm of a 7-year-old child...