myxoma

Summary

Summary: A benign neoplasm derived from connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix, thereby resembling primitive mesenchymal tissue. It occurs frequently intramuscularly where it may be mistaken for a sarcoma. It appears also in the jaws and the skin. (From Stedman, 25th ed)

Top Publications

  1. Schilling J, Engel A, Hassan M, Smith J. Robotic excision of atrial myxoma. J Card Surg. 2012;27:423-6 pubmed publisher
    ..System have facilitated minimally invasive and robotic cardiac procedures including mitral valve repair and atrial myxoma excision...
  2. Albanese M, Nocini P, Fior A, Rizzato A, Cristofaro M, Sancassani G, et al. Mandibular reconstruction using fresh frozen bone allograft after conservative enucleation of a mandibular odontogenic myxoma. J Craniofac Surg. 2012;23:831-5 pubmed publisher
    ..radiographic, and histological findings about a case of a young woman affected by a mandibular odontogenic myxoma. Conservative tumor resection was followed by immediate reconstructive treatment using fresh-frozen human bone ..
  3. Baikoussis N, Siminelakis S, Kotsanti A, Achenbach K, Argyropoulou M, Goudevenos J. Multiple cerebral mycotic aneurysms due to left atrial myxoma: are there any pitfalls for the cardiac surgeon?. Hellenic J Cardiol. 2011;52:466-8 pubmed
    ..atrial myxomas has been well documented, but the formation of multiple cerebral aneurysms resulting from atrial myxoma is a very rare neurological complication...
  4. Blair W, Levine J, Kerwin S, Spaulding K, Young B, Pool R. Imaging diagnosis-synovial myxoma of lumbar vertebrae articular process joint. Vet Radiol Ultrasound. 2011;52:309-12 pubmed publisher
    Magnetic resonance (MR) imaging and histopathology were used to diagnose an articular process synovial myxoma in a dog...
  5. Gomes C, Diniz M, Duarte A, Bernardes V, Gomez R. Molecular review of odontogenic myxoma. Oral Oncol. 2011;47:325-8 pubmed publisher
    Odontogenic myxoma (OM) is a benign odontogenic neoplasm that tends to recur due to bone infiltration. This review focuses on the molecular aspects of the OM...
  6. Zheng J, Geng X, Wang H, Yan Y, Wang H. Clinical and histopathological analysis of 66 cases with cardiac myxoma. Asian Pac J Cancer Prev. 2013;14:1743-6 pubmed
    Cardiac myxoma is a major primary heart tumor which often causes unexpected symptoms or sudden death. This present study was designed to investigate its clinical pathological features and biological behavior.
  7. de Melo W, Pereira Santos D, Brêda M, Sonoda C, Hochuli Vieira E, Serra e Silva F. Using the condylar prosthesis after resection of a large odontogenic myxoma tumor in the mandible. J Craniofac Surg. 2012;23:e398-400 pubmed publisher
    ..The authors report a case of a 20-year-old patient with an odontogenic myxoma tumor located in the left mandibular angle, ascending ramus, and mandibular symphysis...
  8. Oliveira R, Branco L, Galrinho A, Abreu A, Abreu J, Fiarresga A, et al. Cardiac myxoma: a 13-year experience in echocardiographic diagnosis. Rev Port Cardiol. 2010;29:1087-100 pubmed
    ..The authors review their thirteen years' experience on the echocardiographic diagnosis of this pathology...
  9. Pailoor J, Mun K, Chen C, Pillay B. Plexiform angiomyxoid myofibroblastic tumour of the stomach. Pathology. 2009;41:698-9 pubmed publisher

More Information

Publications62

  1. Samanidis G, Perreas K, Kalogris P, Dimitriou S, Balanika M, Amanatidis G, et al. Surgical treatment of primary intracardiac myxoma: 19 years of experience. Interact Cardiovasc Thorac Surg. 2011;13:597-600 pubmed publisher
    Cardiac myxoma is the most common benign tumor of the heart. It presents with a variety of clinical signs and symptomatology making diagnosis frequently quite a challenge...
  2. Jain D, Maleszewski J, Halushka M. Benign cardiac tumors and tumorlike conditions. Ann Diagn Pathol. 2010;14:215-30 pubmed publisher
    ..This comprehensive and up-to-date review describes the key clinical, gross, and histologic findings for 16 distinct entities. It also provides differential diagnoses and key facts to differentiate between similar appearing tumors...
  3. Vohra H, Phillips N, Nel L, Diprose P, Ohri S. Unidentified retained inferior vena cava myxoma detected by intra-operative trans-oesophageal echocardiography. Thorac Cardiovasc Surg. 2010;58:248-50 pubmed publisher
    We report a unilateral right atrial familial myxoma with a multicentric nature discovered during cardiac surgery...
  4. Tan C, Santos L, Biankin A. Plexiform angiomyxoid myofibroblastic tumour of the stomach: a case report. Pathology. 2010;42:581-3 pubmed publisher
  5. Diaz A, Di Salvo C, Lawrence D, Hayward M. Left atrial and right ventricular myxoma: an uncommon presentation of a rare tumour. Interact Cardiovasc Thorac Surg. 2011;12:622-3 pubmed publisher
    ..Transoesophageal echocardiography has become an invaluable tool to diagnose myxomas and plan the surgical approach...
  6. Agaimy A, Strecker T. Left atrial myxoma with papillary fibroelastoma-like features. Int J Clin Exp Pathol. 2011;4:307-11 pubmed
    Although rare, papillary fibroelastoma (PFE) of the heart valves and atrial myxoma represent the two most common cardiac tumors. Coexistence of these two lesions has been documented in rare case reports...
  7. Gassanov N, Nia A, Dahlem K, Ederer S, Wedemeyer I, Caglayan E, et al. Local thrombolysis for successful treatment of acute stroke in an adolescent with cardiac myxoma. ScientificWorldJournal. 2011;11:891-3 pubmed publisher
    ..The mass was excised surgically, confirmed as a benign atrial myxoma, and the patient was discharged with restitution ad integrum...
  8. Koyalakonda S, Mediratta N, Ball J, Royle M. A rare case of aortic valve myxoma: an unusual cause of embolic stroke. Cardiology. 2011;118:101-3 pubmed publisher
    Aortic valve myxoma is an extremely rare cardiac tumour. We describe a 60-year-old woman found to have an aortic valve myxoma and a patent foramen ovale (PFO) presenting as a stroke...
  9. Hekmat M, Rafieian S, Aval Z, Khani M, Taherkhani M, Movahed M. Asymptomatic pediatric pulmonic valve myxoma involving the right ventricular outflow tract: a case report and review of the literature. J Heart Valve Dis. 2012;21:398-400 pubmed
    Asymptomatic pediatric pulmonic valve myxoma involving the right ventricular out flow tract (RVOT) is very rare...
  10. Lahey E, Woo S, Park H. Odontogenic myxoma with diffuse calcifications: a case report and review of the literature. Head Neck Pathol. 2013;7:97-102 pubmed publisher
    This is a case report of an unusual odontogenic myxoma with calcifications, one of three reported in the literature. It had a typical radiographic appearance although it presented in an older patient...
  11. Rickelt S, Rizzo S, Doerflinger Y, Zentgraf H, Basso C, Gerosa G, et al. A novel kind of tumor type-characteristic junction: plakophilin-2 as a major protein of adherens junctions in cardiac myxomata. Mod Pathol. 2010;23:1429-37 pubmed publisher
    ..We propose to examine the marker value of Pkp2 in clinical diagnoses of cardiac myxomata and to develop Pkp2-targeted therapeutic reagents...
  12. Barh D, Kumar A, Chatterjee S, Liloglou T. Molecular features, markers, drug targets, and prospective targeted therapeutics in cardiac myxoma. Curr Cancer Drug Targets. 2009;9:705-16 pubmed
    Treatment of sporadic cardiac myxoma (CM) has always been a challenging task...
  13. Tsang F, Cheng L. Giant myxoma causing right ventricular outflow tract obstruction. Hong Kong Med J. 2011;17:242-4 pubmed
    Atrial cardiac myxoma is the most common benign cardiac tumour. Atrial myxoma most commonly arises from the left atrium and, less frequently, from the right atrium or both ventricles...
  14. Garatti A, Nano G, Canziani A, Gagliardotto P, Mossuto E, Frigiola A, et al. Surgical excision of cardiac myxomas: twenty years experience at a single institution. Ann Thorac Surg. 2012;93:825-31 pubmed publisher
    ..Primary cardiac tumors are quite uncommon and myxomas constitute the major proportion among these masses. The present study summarizes our 20-year clinical experience with surgical resection of intracardiac myxomas...
  15. Miranda Rius J, Nadal A, Lahor E, Mtui B, Brunet L. Unusual presentation of localized gingival enlargement associated with a slow-growing odontogenic myxoma. Int J Oral Sci. 2013;5:172-5 pubmed publisher
    ..Tissue submitted for histopathological analysis rendered the diagnosis of odontogenic myxoma. After 12-month of follow-up, no evidence of recurrence was found...
  16. John A, Connolly H, Schaff H, Klarich K. Management of cardiac myxoma during pregnancy: a case series and review of the literature. Int J Cardiol. 2012;155:177-80 pubmed publisher
    ..We present two cases of cardiac myxoma diagnosed during pregnancy and review the presentation and management strategies of previously reported cases...
  17. Yoshioka D, Takahashi T, Ishizaka T, Higuchi T. Successful surgical resection of infected left atrial myxoma in a case complicated with disseminated intravascular coagulation and multiple cerebral infarctions: case report. J Cardiothorac Surg. 2011;6:68 pubmed publisher
    Cardiac myxoma is the most common primary cardiac tumour, but infected cardiac myxoma is relatively rare...
  18. Gosev I, Paic F, Durić Z, Gošev M, Ivcevic S, Jakuš F, et al. Cardiac myxoma the great imitators: comprehensive histopathological and molecular approach. Int J Cardiol. 2013;164:7-20 pubmed publisher
    ..Majority of cardiac myxoma occur sporadically while a relatively small proportion of diagnosed cases develop as a part of Carney complex ..
  19. Lee S, Kim J, Na C, Oh S. Eleven years' experience with Korean cardiac myxoma patients: focus on embolic complications. Cerebrovasc Dis. 2012;33:471-9 pubmed publisher
    ..This study is based on our clinical experience with cardiac myxomas over a period of 11 years at Sejong General Hospital. We focused on the embolic complications of patients with cardiac myxoma.
  20. Liu C, Jung S, Orlandi A, Yeh T, Lin Y, Shiu T, et al. The Fas-mediated apoptotic pathway in cardiac myxoma. Int J Surg Pathol. 2010;18:493-8 pubmed publisher
    Cardiac myxoma is the most common primary tumor of the heart. The existence of apoptosis in cardiac myxoma has been demonstrated...
  21. Narin B, Arman A, Arslan D, Simsek M, Narin A. Assessment of cardiac masses: magnetic resonance imaging versus transthoracic echocardiography. Anadolu Kardiyol Derg. 2010;10:69-74 pubmed
    ..The purpose of this study is to compare the role of magnetic resonance imaging (MRI) with transthoracic echocardiography (TTE) for characterization of cardiac masses...
  22. Lin Y, Basile J. A case of odontogenic myxoma with unusual histological features mimicking a fibro-osseous process. Head Neck Pathol. 2010;4:253-6 pubmed publisher
    Odontogenic myxoma is a rare benign but locally aggressive odontogenic tumor...
  23. Gheysens O, Cornillie J, Voigt J, Bogaert J, Westhovens R. Left atrial myxoma on FDG-PET/CT. Clin Nucl Med. 2013;38:e421-2 pubmed publisher
    ..echocardiography and contrast-enhanced MRI showed a left atrial pedunculated soft tissue mass suggestive for myxoma, with histological confirmation...
  24. Ting S, Koay C, Ngo C, Chieng L, Chua C. Orbital myxoma--an unusual cause of inferoorbital mass. Med J Malaysia. 2010;65:224-6 pubmed
    ..To describe a case of isolated infraorbital mass which had been present for the past 9 years in a young woman. Despite the size, the mass was successfully excised in total...
  25. Yuan S. Mitral valve myxoma: clinical features, current diagnostic approaches, and surgical management. Cardiol J. 2012;19:105-9 pubmed
    The purpose of this article is to document the clinical features of the unusual mitral valve myxoma based on the literature of recent years.
  26. Nicholls G, Clearwater G. Emergency presentation of emboli to multiple sites from an atrial myxoma. Emerg Med Australas. 2012;24:336-8 pubmed publisher
    ..and fasciotomy could not save his left lower limb, and emergency cardiac surgery was required to excise an atrial myxoma. A brief narrative review of the literature is also presented, with this case being unusual in causing such ..
  27. Iatrou I, Theologie Lygidakis N, Leventis M, Michail Strantzia C. Sinonasal myxoma in an infant. J Craniofac Surg. 2010;21:1649-51 pubmed publisher
    ..region are neoplastic entities of mesenchymal origin most often associated with odontogenic origin; sinonasal myxoma is rare, located in the nasolabial region and originating from the sinonasal tract...
  28. Azevedo O, Almeida J, Nolasco T, Medeiros R, Casanova J, Bartosch C, et al. Massive right atrial myxoma presenting as syncope and exertional dyspnea: case report. Cardiovasc Ultrasound. 2010;8:23 pubmed publisher
    Primary heart neoplasms are rare occurring with an estimated incidence of 0.0017-0.19%. Myxoma is the most prevalent primary heart tumor. The right atrium is an unusual localization, occurring only in 15-20% of myxoma cases...
  29. Darwazah A, Eida M, Batrawy M. Myxoma at junction of inferior vena cava and right atrium: surgical excision. Tex Heart Inst J. 2011;38:591-3 pubmed
    ..We report a case in which we discovered, in a young, asymptomatic woman, an atrial myxoma arising from the anterior-superior junction of the inferior vena cava with the right atrium...
  30. Selkane C, Amahzoune B, Chavanis N, Raisky O, Robin J, Ninet J, et al. Changing management of cardiac myxoma based on a series of 40 cases with long-term follow-up. Ann Thorac Surg. 2003;76:1935-8 pubmed
    Cardiac myxoma is generally considered to be a surgical emergency...
  31. Citro R, Masiello P, Bossone E, Provenza G, Mastrogiovanni G, Baldi C, et al. Giant left atrial myxoma: an unusual cause of acute pulmonary edema. J Am Soc Echocardiogr. 2008;21:978.e1-3 pubmed publisher
    We report a case of a huge left atrial myxoma with an unusual clinical presentation characterized by acute pulmonary edema. The possible pathophysiologic mechanism has been discussed.
  32. Demirci H, Shields C, Eagle R, Shields J. Report of a conjunctival myxoma case and review of the literature. Arch Ophthalmol. 2006;124:735-8 pubmed
  33. Landa L, Hedrick M, Nepomuceno Perez M, Sotereanos G. Recurrent myxoma of the zygoma: a case report. J Oral Maxillofac Surg. 2002;60:704-8 pubmed
  34. Arruda M, Braile D, Joaquim M, Soares M, Alves R. Resection of left ventricular myxoma after embolic stroke. Rev Bras Cir Cardiovasc. 2008;23:578-80 pubmed
    Cardiac myxoma is the most common primary tumor of the heart. The tumor is located mainly in the left atrium but can arise from any heart chamber. Clinical symptoms are variable but dyspnea and embolism are the most frequent...
  35. Quigley M, Schwartzman E, Boswell P, Christensen R, Gleason L, Sharpe R, et al. A unique atrial primary cardiac lymphoma mimicking myxoma presenting with embolic stroke: a case report. Blood. 2003;101:4708-10 pubmed
    ..While tumor emboli from invasive primary cardiac lymphomas have been reported, this noninvasive fibrin thrombus-associated lymphoma appears to be unique and previously unreported...
  36. Liu S, Wang Z, Chen A, Zhou G, Jiang Z, Xiao M. Cardiac myxoma and myxosarcoma: clinical experience and immunohistochemistry. Asian Cardiovasc Thorac Ann. 2002;10:8-11 pubmed
    From January 1978 to February 1999, 120 patients (42 males and 78 females) with cardiac myxoma (115) or myxosarcoma (5) underwent surgical excision or biopsy. There were 5 early postoperative deaths (mortality, 4.2%)...
  37. Ibrahim M, Iliescu C, Safi H, Buja M, McPherson D, Fuentes F. Biatrial myxoma and cerebral ischemia successfully treated with intravenous thrombolytic therapy and surgical resection. Tex Heart Inst J. 2008;35:193-5 pubmed
    ..agent was used successfully--without massive intracranial bleeding--to treat acute stroke induced by atrial myxoma. Our patient, who had biatrial myxomas with a dual blood supply from the right coronary artery, presented with ..
  38. García Quintana A, Martín Lorenzo P, Suárez de Lezo J, Díaz Escofet M, Llorens R, Medina A. [Infected left atrial myxoma]. Rev Esp Cardiol. 2005;58:1358-60 pubmed
    b>Myxoma is the most common primary tumor of the heart. It is uncommon for these tumors to become infected and, at times, clinical presentation is no different from that of an uninfected myxoma...
  39. Dormand E, Prabhu Desai A, Rice A, Rosin R. Not all pain in the left iliac fossa is diverticular disease: A case study of a psoas myxoma and review. Surgeon. 2006;4:239-43 pubmed
    ..We present a case study of an intramuscular myxoma in the psoas muscle, followed by a review of the literature regarding the diagnosis and treatment of intramuscular ..
  40. Willems S, Schrage Y, Baelde J, Briaire de Bruijn I, Mohseny A, Sciot R, et al. Myxoid tumours of soft tissue: the so-called myxoid extracellular matrix is heterogeneous in composition. Histopathology. 2008;52:465-74 pubmed publisher
    ..Myxoid tumours of soft tissue are characterized by their so-called 'myxoid' extracellular matrix. The aim was to investigate the composition and possible function of this matrix which is poorly understood...
  41. Sughimoto K, Shiikawa A, Ohkado A, Nanaumi M. Multiple cardiac myxomas with pulmonary arterial obstruction and acute right heart failure. Jpn J Thorac Cardiovasc Surg. 2004;52:530-3 pubmed
    ..Following the removal of the tumor, symptoms improved drastically. The postoperative course was uneventful...
  42. Coley C, Lee K, Steiner M, Thompson C. Complete embolization of a left atrial myxoma resulting in acute lower extremity ischemia. Tex Heart Inst J. 2005;32:238-40 pubmed
    Atrial myxoma is the most common benign tumor of the heart. Patients who have atrial myoxmas usually present with cardiac obstruction, arrhythmias, or peripheral embolization...
  43. Butany J. Left atrial myxoma presenting as acute inferior wall infarction--a case report. J Card Surg. 2006;21:479-80 pubmed
  44. Nakamura K, Asai T, Murakami M, Saito Y, Yoshimoto A, Yamaguchi H. Giant right atrial myxoma associated with tricuspid regurgitation. Jpn J Thorac Cardiovasc Surg. 2006;54:332-4 pubmed
    ..The defect was closed using an autologous pericardial patch. Tricuspid annuloplasty was carried out with no residual tricuspid regurgitation...
  45. Kim J, Baek W, Kim K, Yoon Y, Kim D, Lim H. A primary cardiac sarcoma preoperatively presented as a benign left atrial myxoma. Yonsei Med J. 2003;44:530-3 pubmed
    ..We report a case of a primary cardiac sarcoma with myxoid change, which originally presented as a benign cardiac myxoma on a two- dimensional echocardiogram...
  46. Mahdhaoui A, Bouraoui H, Amine M, Mokni M, Besma T, Hajri S, et al. The transesophageal echocardiographic diagnosis of left atrial myxoma simulating a left atrial thrombus in the setting of mitral stenosis. Echocardiography. 2004;21:333-6 pubmed
    ..The clinical, electrocardiographic, and radiologic findings suggested mitral stenosis. Left atrial obstructive myxoma simulating a thrombus was found by transthoracic echocardiography (TTE)...
  47. Heitner J, Klem I, Alexander K, Thomson L, Meine T, Patel M, et al. The case of the disappearing myxoma. J Cardiovasc Magn Reson. 2005;7:841-3 pubmed
    ..found to have a cardiac mass on transthoracic and transesophageal echocardiography that was diagnosed as an atrial myxoma. A cardiac magnetic resonance test determined the mass to be more consistent with a thrombus than a myxoma through ..
  48. Gregory S, O Byrne W, Fan P. Infected cardiac myxoma. Echocardiography. 2004;21:65-7 pubmed
    ..We report a case of an infected cardiac myxoma that presented in a manner similar to bacterial endocarditis...
  49. Janion M, Sielski J, Ciuraszkiewicz K. Sepsis complicating giant cardiac myxoma. Am J Emerg Med. 2008;26:387.e3-4 pubmed publisher
    ..A giant tumor fixed to the atrial wall between the pulmonary veins' orifices was excised and confirmed as myxoma in histological tests...
  50. Simon E, Merkx M, Vuhahula E, Ngassapa D, Stoelinga P. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg. 2004;33:333-7 pubmed
    Odontogenic myxoma, a rare tumour that occurs in the jaws, has been reported to be the second commonest odontogenic tumour in many countries...
  51. Chopra P, Ray R, Singh M, Venugopal P. Cardiac myxoma with glandular elements: a histologic, histochemical, and immunohistochemical evaluation. Indian Heart J. 2003;55:182-4 pubmed
    Epithelial differentiation in cardiac myxoma is a rare phenomenon. Out of 104 surgically excised specimens, we studied 3 cases of cardiac myxoma with glandular differentiation...
  52. Noffke C, Raubenheimer E, Chabikuli N, Bouckaert M. Odontogenic myxoma: review of the literature and report of 30 cases from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:101-9 pubmed
    ..The purpose of the study was to analyze the clinical and radiographic features of central odontogenic myxomas (OM) of the jaws diagnosed over 23 years in a black South African patient sample...
  53. Roskell D, Biddolph S. Proliferating cell nuclear antigen expression grossly over-estimates cellular proliferation in cardiac myxomas. Eur J Med Res. 1999;4:105-6 pubmed
    ..Routine microscopy suggests a low proliferation rate. The aim of this study was to investigate cellular proliferation, and to assess its contribution to tumour growth...