myofibroma

Summary

Summary: A benign tumor that consists chiefly of fibrous CONNECTIVE TISSUE, with variable numbers of MUSCLE CELLS forming portions of the neoplasm (From Stedman's, 27th ed).

Top Publications

  1. Mynatt C, Feldman K, Thompson L. Orbital infantile myofibroma: a case report and clinicopathologic review of 24 cases from the literature. Head Neck Pathol. 2011;5:205-15 pubmed publisher
    Isolated orbital infantile myofibroma are rare tumors in the head and neck. The mass-like clinical presentation and variable histologic features result in frequent misdiagnosis and potentially inappropriate clinical management...
  2. Calsina M, Philipone E, Patwardhan M, Eisig S, Prat J, Kazim M. Solitary orbital myofibroma: clinical, radiographic, and histopathologic findings. A report of two cases. Orbit. 2011;30:180-2 pubmed publisher
    ..The second was a round circumscribed orbital floor tumor without bone destruction. Histological diagnosis of myofibroma was rendered in both cases. Solitary myofibromas are rare in the orbit...
  3. Allon I, Vered M, Buchner A, Dayan D. Central (intraosseous) myofibroma of the mandible: clinical, radiologic, and histopathologic features of a rare lesion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:e45-53 pubmed
    b>Myofibroma frequently manifests as a solitary soft tissue tumor and less as simultaneous multiple tumors in both soft tissues and bones...
  4. Kim M, Lee S, Youk E, Lee S, Choi J, Cho K. Solitary myofibroma of the sigmoid colon: case report and review of the literature. Diagn Pathol. 2013;8:90 pubmed publisher
    A 58-year-old woman presented with a solitary myofibroma that arose in the sigmoid colon. Computed tomography revealed a highly enhanced intramural mass (1.3-cm maximum diameter) in the proximal sigmoid colon...
  5. Mentzel T, Dei Tos A, Sapi Z, Kutzner H. Myopericytoma of skin and soft tissues: clinicopathologic and immunohistochemical study of 54 cases. Am J Surg Pathol. 2006;30:104-13 pubmed
    ..However, a broad morphologic spectrum ranging from hypocellular, fibroma-like (3 cases), myofibroma-like (2 cases), angioleiomyoma-like (12 cases), and HPC-like neoplasms (13 cases) to classic myopericytomas (14 ..
  6. Sedghizadeh P, Allen C, Kalmar J, Miloro M, Suster S. Solitary central myofibroma presenting in the gnathic region. Ann Diagn Pathol. 2004;8:284-9 pubmed
    Solitary myofibroma of adults is an uncommon neoplasm that typically arises in soft tissue and subcutaneous sites in the head and neck, but rarely within bone...
  7. Green M, Dorfman H, Villanueva Siles E, Gorlick R, Thornhill B, Weber R, et al. Aggressively recurrent infantile myofibroma of the axilla and shoulder girdle. Skeletal Radiol. 2011;40:357-61 pubmed publisher
    Infantile myofibroma is the most common fibrous tumor of infancy, typically affecting neonates and children under 2 years of age...
  8. Shibuya Y, Takeuchi J, Sakaguchi H, Yokoo S, Umeda M, Komori T. Myofibroma of the mandible. Kobe J Med Sci. 2008;54:E169-73 pubmed
    This article is reporting a case of myofibroma involving the mandible of a 12-year-old boy. The patient did not have any swelling nor any redness but of partial mental nerve hypoesthesia...
  9. Matsuyama A, Hisaoka M, Hashimoto H. Angioleiomyoma: a clinicopathologic and immunohistochemical reappraisal with special reference to the correlation with myopericytoma. Hum Pathol. 2007;38:645-51 pubmed
    ..The concentric structures of myoid cells in angioleiomyomas were, however, consistently negative for desmin. Our data further support the close kinship between angioleiomyoma and myopericytoma that has been recently suggested...

More Information

Publications62

  1. Rodrigues E, Shields C, Eagle R, Marr B, Shields J. Solitary intraosseous orbital myofibroma in four cases. Ophthalmic Plast Reconstr Surg. 2006;22:292-5 pubmed
    To report four pediatric cases of a bone-destructive orbital tumor that proved to be a benign solitary intraosseous myofibroma.
  2. Dray M, McCarthy S, Palmer A, Bonar S, Stalley P, Marjoniemi V, et al. Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases. J Clin Pathol. 2006;59:67-73 pubmed
    ..Only a small number of series describing MPC have been reported. MPC is frequently misdiagnosed as a sarcoma...
  3. Fine S, Davis N, Lykins L, Montgomery E. Solitary testicular myofibroma: a case report and review of the literature. Arch Pathol Lab Med. 2005;129:1322-5 pubmed
    ..To our knowledge, this is the first report of a myofibroma localized within the testis.
  4. Menéndez Arzac R, Valdez Méndez D, Landa R, Guzmán S, Cárdenas E, Cano A. Solitary infantile gastrointestinal myofibroma: case report. J Pediatr Surg. 2005;40:1361-3 pubmed
    ..Histopathologic analysis showed a solitary gastrointestinal myofibroma. This is a very rare tumor, especially as a single lesion, because in world literature, there are less than 10 ..
  5. Merrell S, Rahbar R, Alomari A, Padua H, Vargas S, Neufeld E, et al. Infantile myofibroma or lymphatic malformation: differential diagnosis of neonatal cystic cervicofacial lesions. J Craniofac Surg. 2010;21:422-6 pubmed publisher
    ..The histopathological examination result showed that the lesion was infantile myofibroma. This diagnostic error was attributed to atypical features of infantile myofibroma in this child: unusually ..
  6. Souza D, Loureiro C, Rejas R, Sousa S, Raitz R. Intraosseous myofibroma simulating an odontogenic lesion. J Oral Sci. 2009;51:307-11 pubmed
    b>Myofibroma is a rare benign nodular tumor of the soft tissues, bones, or internal organs, and may affect both children and adults...
  7. Hou Y, Chen L, Xu L, Zhou Y, Arksu S, Zeng H, et al. [Mass of posterior gastric wall]. Zhonghua Bing Li Xue Za Zhi. 2006;35:312-3 pubmed
  8. Andreadis D, Epivatianos A, Samara A, Kirili T, Iordanidis F, Poulopoulos A. Myofibroma of the oral mucosa: a case report. Med Princ Pract. 2012;21:288-91 pubmed publisher
    To report a case of coexisting irritation fibroma and myofibroma in oral mucosa.
  9. Rowan C, Farboud A, Mitchard J, Trinidade A. An unusual myofibroblastic proliferation of the pinna. J Laryngol Otol. 2011;125:415-7 pubmed publisher
    ..Myofibrosis of the ear is rare. Myofibromas are mesenchymal tumours which usually present in infancy but have been reported sporadically in adults...
  10. Bahal A, Gulati D, Tevatia M, Lakhtakia R, Arora M, Muttagikar M. Solitary myofibroma of the breast: a case report. Indian J Pathol Microbiol. 2007;50:773-4 pubmed
    ..The case is presented for an insight into contemporary knowledge about its histogenetic origin, behaviour and prognosis...
  11. Koo P, Goykhman I, Lembert L, Nunes L. MRI features of cellular angiomyofibroma with pathologic correlation. J Magn Reson Imaging. 2009;29:1195-8 pubmed publisher
    ..We present the MRI features of cellular angiofibroma that are consistent with the pathological characteristics of this entity-a benign cellular and fibrous tumor with prominent vascularity...
  12. Nascimento A, Dal Cin P, Cilento B, Perez Atayde A, Kozakewich H, Nose V. Urachal inflammatory myofibroblastic tumor with ALK gene rearrangement: a study of urachal remnants. Urology. 2004;64:140-4 pubmed
    ..Involvement of this remnant by either benign or malignant tumors is very infrequent. A few cases of mesenchymal tumors, such as desmoid tumor and leiomyoma, involving the urachus have been described in published reports...
  13. Kim S, Cho J, Kim S. Inflammatory myofibroblastic pseudotumor of the urinary bladder in a patient with bilateral renal cell carcinoma. J Ultrasound Med. 2008;27:483-6 pubmed
  14. Abramowicz S, Simon L, Kozakewich H, Perez Atayde A, Kaban L, Padwa B. Myofibromas of the jaws in children. J Oral Maxillofac Surg. 2012;70:1880-4 pubmed publisher
    ..The purpose of the present study was to evaluate the treatment outcomes in children with these uncommon benign tumors...
  15. Krauel L, Albert A, Mora J, Sola T, Cruz O, Mortera C, et al. Use of angioembolization as an effective technique for the management of pediatric solid tumors. J Pediatr Surg. 2009;44:1848-55 pubmed publisher
    ..Nevertheless, the overall experience with angioembolization for the treatment of tumors is limited. We report our experience in 7 nonvascular solid pediatric tumors...
  16. Chang J, Kessler H. Masson trichrome stain helps differentiate myofibroma from smooth muscle lesions in the head and neck region. J Formos Med Assoc. 2008;107:767-73 pubmed publisher
    ..This study evaluated the usefulness of the Masson trichrome stain in differentiating myofibromas from smooth muscle lesions in the head and neck region...
  17. Callahan R, Kreutzer J, Debrunner M. Transcatheter management of mid-aortic syndrome secondary to myofibroma presenting in infancy with severe left ventricular dysfunction: a case report. Cardiol Young. 2016;26:799-801 pubmed publisher
    In this study, we summarise a case of a myofibroma causing mid-aortic syndrome due to obstruction of the distal thoracic and abdominal aorta leading to severe left ventricular dysfunction...
  18. Barak S, Wang Z, Miettinen M. Immunoreactivity for calretinin and keratins in desmoid fibromatosis and other myofibroblastic tumors: a diagnostic pitfall. Am J Surg Pathol. 2012;36:1404-9 pubmed publisher
  19. Garcia Perla A, Belmonte Caro R, Infante Cossio P, Muñoz Ramos M, Esteban Ortega F. Upper airway distress due to an oropharyngeal infantile myofibroma. J Craniomaxillofac Surg. 2012;40:e112-4 pubmed publisher
    Infantile myofibroma is an uncommon fibrous tumour of infancy, usually present at birth. It is a rare cause of child airway obstruction, with only one neonatal case reported...
  20. Wilson T, Hellquist H, Ray S, Pickles J. Intranasal myopericytoma. A tumour with perivascular myoid differentiation: the changing nomenclature for haemangiopericytoma. J Laryngol Otol. 2007;121:786-9 pubmed
    ..The close histological relationship between myopericytoma, myofibromatosis, solitary myofibroma and infantile haemangiopericytoma is discussed...
  21. Lin H, Jung D, Lee L, Sadow P, Rocco J. Solitary myofibroma of the oropharynx causing airway obstruction in an adult. Ear Nose Throat J. 2014;93:410-7 pubmed
    ..We present an unusual case of a 44-year-old woman who developed acute airway obstruction from a myofibroma in the oropharynx and accordingly required emergent tracheotomy tube placement...
  22. Gwynn E, Clark P. Inflammatory myofibroblastic tumor associated with renal cell carcinoma. Urology. 2005;66:880 pubmed
    ..Some investigators have suggested that biopsy-proven IMT can be managed conservatively, but the findings of this report have demonstrated the need for radical nephrectomy in this patient population to rule out associated malignancy...
  23. Weaver C, Merritt B, Groben P, Morrell D. A partially regressed, atrophic plaque on a 17-year-old girl: an unusual presentation of myofibromatosis. Pediatr Dermatol. 2010;27:481-4 pubmed publisher
    ..We report a case of a 17-year-old girl with a solitary myofibroma on the right leg that presented as a partially regressed, atrophic plaque with multiple surrounding papules...
  24. Kuo P, Spooner S, Deol P, Monchamp T. Metastatic inflammatory myofibroblastic tumor imaged by PET/CT. Clin Nucl Med. 2006;31:106-8 pubmed
  25. Brasileiro B, Martins Filho P, Piva M, da Silva L, Nonaka C, Miguel M. Myofibroma of the oral cavity. A rare spindle cell neoplasm. Med Oral Patol Oral Cir Bucal. 2010;15:e596-600 pubmed
    b>Myofibroma is an uncommon spindle cell neoplasm rarely found in oral cavity. Typically, this lesion is seen in neonates and infants with few cases reported in adults patients...
  26. Friedman B, Shah K, Taylor J, Rubin A. Congenital myofibroma masquerading as an ulcerated infantile hemangioma in a neonate. Pediatr Dermatol. 2013;30:e248-9 pubmed publisher
    We report a case of a solitary infantile myofibroma masquerading as an ulcerated infantile hemangioma. Infantile myofibroma is a rare soft tissue tumor that has a good prognosis in the solitary form...
  27. Nouri H, Aderdour L, Maliki O, Bassi L, Baallal H, Brahimi M, et al. [Myofibroma of the mandibule: a case report]. Rev Laryngol Otol Rhinol (Bord). 2011;132:115-7 pubmed
    ..The recent observation of a patient with a myofibrome of the mandible has given the opportunity to conduct an analysis and review of the literature of this disease rarely encountered...
  28. Jiang Y, Cheng B, Ge M, Cheng Y, Zhang G. Comparison of the clinical and immunohistochemical features, including anaplastic lymphoma kinase (ALK) and p53, in inflammatory myofibroblastic tumours. J Int Med Res. 2009;37:867-77 pubmed
    ..No correlation was found between p53 expression and any clinicopathological feature of IMT...
  29. Yoshida A, Klimstra D, Antonescu C. Plexiform angiomyxoid tumor of the stomach. Am J Surg Pathol. 2008;32:1910-2; author reply 1912-3 pubmed publisher
  30. Venizelos I, Papathomas T, Anagnostou E, Tsanakas J, Kirvassilis F, Kontzoglou G. Pediatric inflammatory myofibroblastic tumor of the trachea: a case report and review of the literature. Pediatr Pulmonol. 2008;43:831-5 pubmed publisher
    ..In particular, we describe the clinical and pathologic features of this patient and present a review of all reported lesions in the available literature...
  31. Swain R, Tihan T, Horvai A, Di Vizio D, Loda M, Burger P, et al. Inflammatory myofibroblastic tumor of the central nervous system and its relationship to inflammatory pseudotumor. Hum Pathol. 2008;39:410-9 pubmed publisher
    ..Neither IMT nor IP cases demonstrated HHV-8 expression. We suggest that IMT in the CNS is distinct from the nonneoplastic IP, and distinguishing IMT from nonneoplastic lesions should enable better decisions for patient management...
  32. Velez M, Billings S, Weaver J. Fibroblastic connective tissue nevus. J Cutan Pathol. 2016;43:75-9 pubmed publisher
    ..The overall features were consistent with a diagnosis of FCTN. In two cases, we further elucidated the fibroblastic differentiation of the spindle cells in FCTN with electron microscopy, which has not been previously described. ..
  33. Wilson M, Emil S, Cowan K, Kalechstein S, Puligandla P, Nguyen V, et al. Infantile myofibromas obstructing opposite ends of the gastrointestinal tract. J Pediatr Surg. 2013;48:449-53 pubmed publisher
    ..Lessons learned from the treatment of these two patients are shared and the pertinent literature is reviewed...
  34. Macintosh P, Grob S, Stagner A, Kazlas M, Jakobiec F, Yoon M, et al. Multicentric myofibromatosis presenting as a large congenital eyelid myofibroma. J AAPOS. 2016;20:70-3 pubmed publisher
    ..Urgent biopsy was performed to evaluate for malignancy. Histopathologic analysis demonstrated myofibroma. Although these lesions have been reported to regress spontaneously, debulking surgery was performed to prevent ..
  35. Asadi Amoli F, Sina A, Kasai A, Ayan Z. A well-known lesion in an unusual location: infantile myofibroma of the eyelid: a case report and review of literature. Acta Med Iran. 2010;48:412-6 pubmed
    b>Myofibroma is a neoplasia of myofibroblasts that can be solitary or multiple and it is found most commonly in the head & neck region including scalp, forehead, parotid region and oral cavity. In the eyelid it is rarely reported...
  36. Eze N, Pitkin L, Crowley S, Wilson P, Daya H. Solitary infantile myofibroma compromising the airway. Int J Pediatr Otorhinolaryngol. 2004;68:1533-7 pubmed
    ..growing oropharyngeal lesion obstructing the airway that had the typical histological features of an infantile myofibroma. This case report highlights that a solitary myofibroma may be incredibly extensive making complete excision ..
  37. Swierkowski P, Seex K. Soft tissue solitary adult myofibroma in an intervertebral foramen. ANZ J Surg. 2004;74:1028-30 pubmed
  38. Gilaberte Y, Coscojuela C, Doste D, Vera J, Requena L. Dermatomyofibroma in a male child. J Eur Acad Dermatol Venereol. 2005;19:257-9 pubmed
  39. Alaggio R, Cecchetto G, Bisogno G, Gambini C, Calabrò M, Inserra A, et al. Inflammatory myofibroblastic tumors in childhood: a report from the Italian Cooperative Group studies. Cancer. 2010;116:216-26 pubmed publisher
    ..The objective of the study was to identify morphologic or immunohistochemical prognostic markers and the possible pathogenic role of human herpes virus 8 (HHV-8)...
  40. Macedo P, Mann D, Zimmerman C, Alves M, Daxbacher E. Dermatomyofibroma: a case report of a rare disease. An Bras Dermatol. 2011;86:120-3 pubmed
    Dermato myofibroma is included in the group of benign cutaneous mesenchymal neoplastic lesions of fibroblastic and myofibroblastic lineage...
  41. Pailoor J, Mun K, Chen C, Pillay B. Plexiform angiomyxoid myofibroblastic tumour of the stomach. Pathology. 2009;41:698-9 pubmed publisher
  42. Bi R, Yin W, Liu X, Wei H, Sheng W, Wang J. [Plexiform angiomyxoid myofibroblastic tumor of stomach]. Zhonghua Bing Li Xue Za Zhi. 2012;41:756-60 pubmed publisher
    ..To study the clinicopathologic features, immunophenotype and differential diagnosis of plexiform angiomyxoid myofibroblastic tumor (PAMT) of the stomach...
  43. Chtourou I, Krichen Makni S, Dhouib M, Khabir A, Fakhfakh I, Ayadi L, et al. [Pediatric mandibular myofibromatosis]. Rev Stomatol Chir Maxillofac. 2007;108:461-4 pubmed
    ..The aim of this article was to report the anatomoclinical and therapeutic features of this pediatric tumor in a case as well as its follow-up...
  44. Poh C, Priddy R, Dahlman D. Intramandibular inflammatory myofibroblastic tumor--a true neoplasm or reactive lesion?. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;100:460-6 pubmed
    ..The purpose of this study is to report the first intramandibular IMT and to discuss the possible nature of this lesion...
  45. Wang Z, Zhao X, Li K, Yao W, Dong K, Xiao X, et al. Analysis of clinical features and outcomes for inflammatory myofibroblastic tumors in China: 11 years of experience at a single center. Pediatr Surg Int. 2016;32:239-43 pubmed publisher
    ..IMT is a benign neoplasm that rarely presents with malignant features. Complete resection is curative in most patients. ALK+ is variable for diagnosis. Close follow-up is necessary for patients who undergo surgical resection. ..
  46. Wang W, Li J, Li G. Plexiform angiomyxoid myofibroblastic tumour of the gastric fundus: successful diagnosis and treatment by endoscopy. J Clin Pathol. 2010;63:569-70 pubmed publisher
  47. Inoue T, Sada A, Mori T, Misago N, Narisawa Y. Congenital myofibroma of the skin mimicking a piloleiomyoma. J Cutan Pathol. 2010;37:678-82 pubmed publisher
    b>Myofibroma is an uncommon benign soft tissue disorder, which is usually congenital or present in early infancy. Myofibroma usually manifests as a single mass. When there are multiple lesions, the term myofibromatosis is used...
  48. Rai B, Ludusan E, McGovern B, Sharif F. Mandibular swelling in a 5-year-old child--mandibular myofibroma. BMJ Case Rep. 2014;2014: pubmed publisher
    ..Incisional biopsy performed and microscopy showed spindle cell tumor. Immunohistochemistry confirmed it as myofibroma. Myofibroma is a rare benign tumour involving mesenchyme. Involvement of the mandible is rare...
  49. Servat J, Williamson J, Piepmeier J, Sinard J, Bernardino C. Giant myofibroma of the orbit in an adult male. Orbit. 2012;31:21-3 pubmed publisher
    ..stains were positive for vimentin and multifocally for smooth muscle actin, supporting the diagnosis of orbital myofibroma. Although orbital myofibromas typically present during childhood, they may occur in older patients and act as an ..
  50. Patel V, Kharkar V, Khopkar U. Adult cutaneous myofibroma. Indian J Dermatol Venereol Leprol. 2008;74:56-8 pubmed
    ..The diagnosis of adult cutaneous myofibroma was made. This case highlights the importance of histopathology in reaching a definitive diagnosis.
  51. Morgan P, Chundru S, Hatch S, Hawkins H, Adegboyega P, Eltorky M. Uncommon malignancies: case 1. Low-grade myofibroblastic sarcoma of the breast. J Clin Oncol. 2005;23:6249-51 pubmed
  52. Yazici B, Bilge A, Yazici Z, Yalçinkaya U. Congenital cranio-orbital myofibroma. Ophthalmic Plast Reconstr Surg. 2011;27:e108-11 pubmed publisher
    ..Based on histologic findings, a diagnosis of infantile myofibroma was made. No involvement was found in other areas of the body...
  53. Patne S, Katiyar R, Chaudhary D, Trivedi S. Dysuria and fever in a young woman diagnosed as having inflammatory myofibroblastic tumour of the urinary bladder. BMJ Case Rep. 2016;2016: pubmed publisher
    ..After TURBT, her fever and urinary symptoms resolved. Her 1-month postoperative period was uneventful. She has been advised regular follow-up. ..