mastocytoma

Summary

Summary: A solid tumor consisting of a dense infiltration of MAST CELLS. It is generally benign.

Top Publications

  1. Rebuzzi L, Willmann M, Sonneck K, Gleixner K, Florian S, Kondo R, et al. Detection of vascular endothelial growth factor (VEGF) and VEGF receptors Flt-1 and KDR in canine mastocytoma cells. Vet Immunol Immunopathol. 2007;115:320-33 pubmed
    ..present study, we have investigated expression of VEGF and VEGF receptors in canine mastocytomas and the canine mastocytoma cell line C2...
  2. Welle M, Bley C, Howard J, Rüfenacht S. Canine mast cell tumours: a review of the pathogenesis, clinical features, pathology and treatment. Vet Dermatol. 2008;19:321-39 pubmed publisher
    ..Furthermore, detailed information about current treatment protocols for canine cutaneous MCTs is provided...
  3. Seidel A, Gueck T, Fuhrmann H. The Influence of long-chain polyunsaturated fatty acids on total lipid fatty acid composition of a canine mastocytoma cell line. J Vet Med A Physiol Pathol Clin Med. 2005;52:219-24 pubmed
    ..of this study was to examine the effects of n6- and n3-fatty acids on the fatty acid composition of canine mastocytoma cells (C2) as a possible model for CAD...
  4. Mederle O, Mederle N, Bocan E, Ceausu R, Raica M. VEGF expression in dog mastocytoma. Rev Med Chir Soc Med Nat Iasi. 2010;114:185-8 pubmed
    ..Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis and a potential autocrine growth factor for neoplastic cells in various malignancies...
  5. Okada Y, Nishikawa J, Semma M, Ichikawa A. Induction of integrin ?3 in PGE?-stimulated adhesion of mastocytoma P-815 cells to the Arg-Gly-Asp-enriched fragment of fibronectin. Biochem Pharmacol. 2011;81:866-72 pubmed publisher
    We previously demonstrated that prostaglandin (PG) E? stimulates adhesion of mastocytoma P-815 cells (P-815 cells) to the Arg-Gly-Asp (RGD)-enriched matrix via the PGE? receptor subtype EP4 [Hatae N, Kita A, Tanaka S, Sugimoto Y, ..
  6. Yee S, Baek S, Park H, Jeong S, Jeong J, Kim T, et al. zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells. Exp Mol Med. 2006;38:634-42 pubmed
    ..BocD-fmk), at usual dosage could not prevent genistein-induced apoptosis of p815 mastocytoma cells...
  7. Furuta K, Nakayama K, Sugimoto Y, Ichikawa A, Tanaka S. Activation of histidine decarboxylase through post-translational cleavage by caspase-9 in a mouse mastocytoma P-815. J Biol Chem. 2007;282:13438-46 pubmed
    ..We investigated the processing of HDC in a mouse mastocytoma, P-815, using a lentiviral expression system...
  8. Bagriacik E, Uslu K, Yurtcu E, Stefek M, Karasu C. Stobadine inhibits doxorubicin-induced apoptosis through a caspase-9 dependent pathway in P815 mastocytoma cells. Cell Biol Int. 2007;31:979-84 pubmed
    ..We found that the antioxidative effects of stobadine were comparable to the effects of a well known antioxidant, N-acetyl l-cysteine (NAC)...
  9. Zemke D, Yamini B, Yuzbasiyan Gurkan V. Mutations in the juxtamembrane domain of c-KIT are associated with higher grade mast cell tumors in dogs. Vet Pathol. 2002;39:529-35 pubmed
    ..A significant association was found between the presence of a mutation and a higher grade of tumor but not between breed and grade or between breed and the presence of a mutation...

More Information

Publications62

  1. Kim E, Yin S, Kang M, Hong J, Oh K, Lee M. Reduction of serotonin content by tetrahydropapaveroline in murine mastocytoma P815 cells. Neurosci Lett. 2003;339:131-4 pubmed
    The inhibitory effects of tetrahydropapaveroline on serotonin biosynthesis in serotonin-producing murine mastocytoma P815 cells were investigated...
  2. Yang Y, Liu C, Peng W, Lizee G, Overwijk W, Liu Y, et al. Antitumor T-cell responses contribute to the effects of dasatinib on c-KIT mutant murine mastocytoma and are potentiated by anti-OX40. Blood. 2012;120:4533-43 pubmed publisher
    ..study, we report that the in vivo antitumor effects of the c-KIT inhibitor, dasatinib, on the c-KIT mutant P815 mastocytoma tumor were substantially dependent on T cell-mediated immunity...
  3. Mroz P, Vatansever F, Muchowicz A, Hamblin M. Photodynamic therapy of murine mastocytoma induces specific immune responses against the cancer/testis antigen P1A. Cancer Res. 2013;73:6462-70 pubmed publisher
    ..out PDT using benzoporphyrin derivative and 690-nm light after 15 minutes, in DBA/2 mice bearing either the mastocytoma, P815, which expresses the naturally occurring cancer/testis antigen P1A, or the corresponding tumor P1...
  4. Elders R, Baines S, Catchpole B. Susceptibility of the C2 canine mastocytoma cell line to the effects of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Vet Immunol Immunopathol. 2009;130:11-6 pubmed publisher
    ..The aim of the current study was to investigate the effect of TRAIL on the canine C2 mastocytoma cell line to determine whether this agent might be a suitable treatment for mast cell tumors in dogs...
  5. Riva F, Brizzola S, Stefanello D, Crema S, Turin L. A study of mutations in the c-kit gene of 32 dogs with mastocytoma. J Vet Diagn Invest. 2005;17:385-8 pubmed
    ..juxtamembrane domain of the c-kit gene in 32 dogs with different grades of histologically confirmed mastocytoma were studied...
  6. Sakai H, Noda A, Shirai N, Iidaka T, Yanai T, Masegi T. Proliferative activity of canine mast cell tumours evaluated by bromodeoxyuridine incorporation and Ki-67 expression. J Comp Pathol. 2002;127:233-8 pubmed
    ..This strong correlation indicated that Ki-67 was, like BrdU, a useful marker for proliferative potential in canine mast cell tumours; moreover, its use did not require the prior administration of any reagent to the live animal...
  7. Schmutzler S, Bachmann L, Fuhrmann H, Schumann J. PUFA-dependent alteration of oxidative parameters of a canine mastocytoma cell line. Acta Vet Hung. 2010;58:453-64 pubmed publisher
    ..study, we investigated the influence of polyunsaturated fatty acids (PUFAs) on oxidative parameters of a canine mastocytoma cell line...
  8. Kiupel M, Webster J, Bailey K, Best S, DeLay J, Detrisac C, et al. Proposal of a 2-tier histologic grading system for canine cutaneous mast cell tumors to more accurately predict biological behavior. Vet Pathol. 2011;48:147-55 pubmed publisher
    ..The median survival time was less than 4 months for high-grade MCTs but more than 2 years for low-grade MCTs...
  9. Hahn K, Ogilvie G, Oglivie G, Rusk T, Devauchelle P, Leblanc A, et al. Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med. 2008;22:1301-9 pubmed publisher
    ..Activation of the KIT receptor tyrosine kinase is associated with the development of canine mast cell tumors (MCT)...
  10. Marriott D, Russell J, Grebosky J, Wallace A, Joste N, Royce M. Idiopathic granulomatous lobular mastitis masquerading as a breast abscess and breast carcinoma. Am J Clin Oncol. 2007;30:564-5 pubmed
  11. Martinez J, Martinez V, Grau Roma L, Lopez J, Segales J. Multiple cutaneous mast cell tumors in a pig. J Vet Diagn Invest. 2011;23:1222-5 pubmed publisher
    ..The presence of eosinophils and the observation, at high magnification, of cells with cytoplasmic metachromatic granules, after toluidine blue staining, confirmed the diagnosis of multiple cutaneous mast cell tumors...
  12. Singalavanija S, Limpongsanurak W. Cutaneous mastocytosis in Thai children. J Med Assoc Thai. 2008;91 Suppl 3:S143-6 pubmed
    ..Mastocytosis is a disorder of mast cells proliferation within various organs, most commonly in the skin. The disease more commonly appears during infancy than adult...
  13. Kodre V, Cemazar M, Pecar J, Sersa G, Cor A, Tozon N. Electrochemotherapy compared to surgery for treatment of canine mast cell tumours. In Vivo. 2009;23:55-62 pubmed
    ..The aim of this study was to evaluate the effectiveness of local treatment electrochemotherapy (ECT) with cisplatin and to compare it with effectiveness of surgery for treatment of mast cell tumours (MCT) in dogs...
  14. Jakab C, Szasz A, Kulka J, Schaff Z, Rusvai M, Nemeth T, et al. Cutaneous mast cell tumour within a lipoma in a boxer. Acta Vet Hung. 2009;57:263-74 pubmed publisher
    ..1%. Between the benign neoplastic lipocytes and mastocytoma tumour cells intratumoural microvessels were detected by immunohistochemical staining using CD31 and claudin-5 ..
  15. Demotte N, Wieërs G, Van Der Smissen P, Moser M, Schmidt C, Thielemans K, et al. A galectin-3 ligand corrects the impaired function of human CD4 and CD8 tumor-infiltrating lymphocytes and favors tumor rejection in mice. Cancer Res. 2010;70:7476-88 pubmed publisher
    ..In nonvaccinated mice, GCS-100 had no effect by itself. These results suggest that a combination of galectin-3 ligands and therapeutic vaccination may induce more tumor regressions in cancer patients than vaccination alone...
  16. Okada Y, Ueyama K, Nishikawa J, Semma M, Ichikawa A. Effect of 6-O-?-maltosyl-? cyclodextrin and its cholesterol inclusion complex on cellular cholesterol levels and ABCA1 and ABCG1 expression in mouse mastocytoma P-815 cells. Carbohydr Res. 2012;357:68-74 pubmed publisher
    ..and cholesterol/Mal-?CD inclusion complex (CLM) on cellular cholesterol levels in a mouse mast cell line, mastocytoma P-815 cells (P-815 cells)...
  17. Costa R, Assreuy J. Nitric oxide inhibits irreversibly P815 cell proliferation: involvement of potassium channels. Cell Prolif. 2002;35:321-32 pubmed
    ..and, as NO activates these channels, we investigated the effect of NO on the proliferation of murine mastocytoma cell lines and the putative involvement of potassium channels...
  18. Hasegawa H, Ichiyama A. Distinctive iron requirement of tryptophan 5-monooxygenase: TPH1 requires dissociable ferrous iron. Biochem Biophys Res Commun. 2005;338:277-84 pubmed
  19. Nishioka Y, Wen H, Mitani K, Robbins P, Lotze M, Sone S, et al. Differential effects of IL-12 on the generation of alloreactive CTL mediated by murine and human dendritic cells: a critical role for nitric oxide. J Leukoc Biol. 2003;73:621-9 pubmed
    ..These results suggest that NO produced by DCs might play an important role in IL-12-mediated immune suppression in mice but not in humans...
  20. Guck T, Fuhrmann H. [Pathobiochemical importance of phospholipases for the release of mast cell mediators]. Dtsch Tierarztl Wochenschr. 2005;112:404-7 pubmed
    ..of polyunsaturated fatty acids on the activity of the cytosolic phospholipase A2 (cPLA2) in the canine mastocytoma cell line C2 as a model for canine atopic dermatitis (CAD)...
  21. Wang L, Liu J, Talebian F, El Omrani H, Khattabi M, Yu L, et al. Tumor expression of CD200 inhibits IL-10 production by tumor-associated myeloid cells and prevents tumor immune evasion of CTL therapy. Eur J Immunol. 2010;40:2569-79 pubmed publisher
    ..To evaluate this issue, we generated CD200-positive mouse plasmacytoma J558 and mastocytoma P815 cells...
  22. Mempel M, Ronet C, Lemaitre F, Lim A, Kourilsky P, Gachelin G, et al. The intratumoral application of poly-G-oligodeoxynucleotides does not augment the naturally induced antitumoral CD8-T-cell response in P815 mastocytomas. Immunol Lett. 2003;89:47-57 pubmed
    ..We used the well described poly-G-ODN 1628 in its capacity to enhance antitumoral CD8 response in the cutaneous mastocytoma P815...
  23. Thompson J, Yager J, Best S, Pearl D, Coomber B, Torres R, et al. Canine subcutaneous mast cell tumors: cellular proliferation and KIT expression as prognostic indices. Vet Pathol. 2011;48:169-81 pubmed publisher
  24. Yee S, Kim M, Baek S, Kim G, Yoo K, Yoo Y, et al. Trichostatin A induces apoptosis of p815 mastocytoma cells in histone acetylation- and mitochondria-dependent fashion. Int J Oncol. 2004;25:1431-6 pubmed
    ..Here we studied whether a histone deacetylase inhibitor Trichostatin A (TSA) produces apoptosis in p815 mastocytoma cells...
  25. Fujimoto T, Sato Y, Sasaki N, Teshima R, Hanaoka K, Kitani S. The canine mast cell activation via CRP. Biochem Biophys Res Commun. 2003;301:212-7 pubmed
    We report here canine mastocytoma-derived cell (CMMC) activation via two pentraxin, limulus- and human-CRP. Mast cell chemotaxis was measured by Boyden's blindwell chamber...
  26. Zhao C, Morgan M, Haeryfar S, Blay J, Hoskin D. Exposure to paclitaxel or vinblastine down-regulates CD11a and CD54 expression by P815 mastocytoma cells and renders the tumor cells resistant to killing by nonspecific cytotoxic T lymphocytes induced with anti-CD3 antibody. Cancer Immunol Immunother. 2003;52:185-93 pubmed
    ..EC(25) and EC(50)) of paclitaxel or vinblastine on the subsequent susceptibility of surviving P815 murine mastocytoma cells to cytolysis by major histocompatibility complex (MHC)-unrestricted mouse cytotoxic T lymphocytes that ..
  27. Watanabe D, Goshima F, Mori I, Tamada Y, Matsumoto Y, Nishiyama Y. Oncolytic virotherapy for malignant melanoma with herpes simplex virus type 1 mutant HF10. J Dermatol Sci. 2008;50:185-96 pubmed publisher
    ..Many viruses have been engineered and evaluated for their potential as therapeutic agents in the treatment of malignant neoplasm, including malignant melanoma...
  28. Mo J, Streilein J. Analysis of immune privilege in eyes with Mycobacteria tuberculosa adjuvant-induced uveitis. Ocul Immunol Inflamm. 2005;13:139-47 pubmed
    ..To examine the effects of intravitreal Mycobacteria tuberculosa adjuvant (MTA) on ocular immune privilege...
  29. Reguera M, Ferrer L, Rabanal R. Evaluation of an intron deletion in the c-kit gene of canine mast cell tumors. Am J Vet Res. 2002;63:1257-61 pubmed
    ..To evaluate molecular abnormalities in the c-kit gene of canine mast cell tumors (MCT) with different grades of cellular differentiation...
  30. Thompson J, Pearl D, Yager J, Best S, Coomber B, Foster R. Canine subcutaneous mast cell tumor: characterization and prognostic indices. Vet Pathol. 2011;48:156-68 pubmed publisher
    ..The results of the study indicate that the majority of subcutaneous MCTs have a favorable prognosis, with extended survival times and low rates of reoccurrence and metastasis...
  31. Sotlar K. [Molecular pathological analysis of neoplastic mast cells with regard to the actual WHO classification of mast cell neoplasias]. Verh Dtsch Ges Pathol. 2006;90:227-35 pubmed
    ..By establishing methods for the detection of c-kit codon 816 mutations in paraffin-embedded tissues, the pathologist holds a central position in the diagnosis of systemic mastocytoses...
  32. Moriello K. Clinical snapshot. Cutaneous nodules in a cat. Compend Contin Educ Vet. 2007;29:204, 240 pubmed
  33. Hadzijusufovic E, Peter B, Herrmann H, Rülicke T, Cerny Reiterer S, Schuch K, et al. NI-1: a novel canine mastocytoma model for studying drug resistance and IgER-dependent mast cell activation. Allergy. 2012;67:858-68 pubmed publisher
    ..Kit mutations supposedly contribute to abnormal growth and drug resistance in these patients...
  34. Graille M, Huyghe F, Nicolier A. Mastocytemia associated with a visceral mast cell tumor in a Sumatran tiger (Panthera tigris). J Zoo Wildl Med. 2013;44:189-92 pubmed
    ..Hematologic, postmortem, and histologic findings were consistent with mastocytemia associated with the splenic form of mast cell tumor described in domestic cats...
  35. Elliott J, Cripps P, Blackwood L, Berlato D, Murphy S, Grant I. Canine oral mucosal mast cell tumours. Vet Comp Oncol. 2016;14:101-11 pubmed publisher
    ..Despite a more aggressive clinical course, treatment can result in protracted survivals, even when metastasis is present. ..
  36. Tahara H, Fujio K, Araki Y, Setoguchi K, Misaki Y, Kitamura T, et al. Reconstitution of CD8+ T cells by retroviral transfer of the TCR alpha beta-chain genes isolated from a clonally expanded P815-infiltrating lymphocyte. J Immunol. 2003;171:2154-60 pubmed
  37. Borsotti C, Franklin A, Lu S, Kim T, Smith O, Suh D, et al. Absence of donor T-cell-derived soluble TNF decreases graft-versus-host disease without impairing graft-versus-tumor activity. Blood. 2007;110:783-6 pubmed
    ..These data suggest that suppressing the secretion of solTNF by donor T cells significantly decreases GVHD without impairing GVT activity...
  38. van der Luer R, Teske E, Rutteman G, van den Ingh T. [Prognosis, mitotic index and cell proliferation markers of mastocytoma in a dog]. Tijdschr Diergeneeskd. 2008;133:522-3 pubmed
  39. Filipowska B, Gebska E, Pindycka Piaszczyńska M, Sabat D, Zajecki W. [Coexistence of pigmented urticaria and mastocytomas: a case report]. Pol Merkur Lekarski. 2003;14:441-3 pubmed
    ..The histopathological examination of the node confirmed the diagnosis of mastocytoma. A bone scintigram showed an increased uptake of radiotechnetium around the right coxal region...
  40. Kiszewski A, Alvarez Mendoza A, Ríos Barrera V, Hernandez Pando R, Ruiz Maldonado R. Mastocytosis in children: clinicopathological study based on 35 cases. Histol Histopathol. 2007;22:535-9 pubmed publisher
    ..The immunohistochemistry with c-kit might make CM diagnosis easier, especially in the macular cases, when there is a lower number of MC...
  41. Nicoll G, Avril T, Lock K, Furukawa K, Bovin N, Crocker P. Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. Eur J Immunol. 2003;33:1642-8 pubmed
    ..These findings have important implications for NK cell cytotoxicity against tumor cells like melanoma that express high levels of GD3 ganglioside...
  42. Nakamura R, Sato Y, Takagi K, Sasaki N, Sawada J, Kitani S, et al. Presence and primary sequence of a high-affinity IgG receptor on canine mastocytoma (CM-MC) cells. Immunogenetics. 2003;55:271-4 pubmed
    ..only low-affinity IgG receptors and no high-affinity receptors (FcgammaRI), our recent study showed that canine mastocytoma CM-MC cells are activated by monomeric canine IgG, suggesting the presence of FcgammaRI on CM-MC cells...
  43. LeBlanc A, Jakoby B, Townsend D, Daniel G. 18FDG-PET imaging in canine lymphoma and cutaneous mast cell tumor. Vet Radiol Ultrasound. 2009;50:215-23 pubmed
    ..18FDG-PET holds promise as a whole-body staging method for canine LSA and MCT...
  44. Hadzijusufovic E, Peter B, Gleixner K, Schuch K, Pickl W, Thaiwong T, et al. H1-receptor antagonists terfenadine and loratadine inhibit spontaneous growth of neoplastic mast cells. Exp Hematol. 2010;38:896-907 pubmed publisher
    ..A key mediator of MCs responsible for clinical symptoms is histamine. Therefore, use of histamine receptor (HR) antagonists is an established approach to block histamine effects in these patients...
  45. Collins J, Degner D, Bhandal J. Use of an axial pattern skin flap based on the cranial cutaneous branch of the saphenous artery in the dog. Vet Comp Orthop Traumatol. 2011;24:307-10 pubmed publisher
    ..To report the use of an axial pattern flap based on the cranial cutaneous branch of the saphenous artery to close a skin defect left on the medial crus after mast cell tumour removal...
  46. Davies D, Wyatt K, Jardine J, Robertson I, Irwin P. Vinblastine and prednisolone as adjunctive therapy for canine cutaneous mast cell tumors. J Am Anim Hosp Assoc. 2004;40:124-30 pubmed
    ..Fourteen dogs were free of MCT. There was no confirmed tumor-related mortality. Although toxicity from the chemotherapy was generally mild, one dog died of sepsis during treatment...
  47. Koh M, Chong W. Red plaque after hepatitis B vaccination. Pediatr Dermatol. 2008;25:381-2 pubmed publisher
  48. Garrett L, Craig C, Szladovits B, Chun R. Evaluation of buffy coat smears for circulating mast cells in healthy cats and ill cats without mast cell tumor-related disease. J Am Vet Med Assoc. 2007;231:1685-7 pubmed
    ..To examine buffy coat smears for circulating mast cells in clinically normal cats and cats with illnesses unrelated to mast cell tumors and identify whether conditions other than mast cell tumors are associated with mastocytemia in cats...
  49. Seguin B, Besancon M, McCallan J, Dewe L, Tenwolde M, Wong E, et al. Recurrence rate, clinical outcome, and cellular proliferation indices as prognostic indicators after incomplete surgical excision of cutaneous grade II mast cell tumors: 28 dogs (1994-2002). J Vet Intern Med. 2006;20:933-40 pubmed
    ..However, local recurrence can negatively affect survival of the affected dogs. Cellular proliferation indices may indicate the likelihood of MCT recurrence after incomplete excision...
  50. Taylor F, Murphy S, Hoather T, Dobson J, Scase T. TSLC1 tumour-suppressor gene expression in canine mast cell tumours. Vet Comp Oncol. 2010;8:263-72 pubmed publisher
    ..002857). For Group 2 there was a trend towards dogs with lower TSLC1 scores being more likely to die from MCT-related disease (P = 0.058). The intensity of TSLC1 staining inversely correlated with Ki67 expression for both groups...
  51. Spugnini E, Vincenzi B, Baldi F, Citro G, Baldi A. Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors. Anticancer Res. 2006;26:4585-9 pubmed
    ..The purpose of this investigation was to assess the adjuvant potentials of ECT for the treatment of incompletely excised mast cell tumors (MCT)...
  52. Wang Q, Feng Z, Zhou Y, Nie Q, Bai X. [Antitumor activity on murine mastocytoma induced by immunization with fusion of dendritic cells and P815 cells in mice]. Zhonghua Gan Zang Bing Za Zhi. 2004;12:559-60 pubmed
  53. Dutta P, Koch A, Breyer B, Schneider H, Dittrich Breiholz O, Kracht M, et al. Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis. BMC Genomics. 2011;12:196 pubmed publisher
    ..However, the exact role of NGF in hematopoietic system is unclear. It is also not clear whether NGF mediated signals in hematopoietic cells are identical to those in neuronal cells...