giant cell tumors

Summary

Summary: Tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.

Top Publications

  1. Uriburu I, Levy V. Intraosseous growth of giant cell tumors of the tendon sheath (localized nodular tenosynovitis) of the digits: report of 15 cases. J Hand Surg Am. 1998;23:732-6 pubmed
    b>Giant cell tumors of tendon sheath are common soft tissue lesions affecting the digits, sometimes causing pressure atrophy of an adjoining bone and rarely perforating the cortex to expand into the medullary canal...
  2. Reilly K, Stern P, Dale J. Recurrent giant cell tumors of the tendon sheath. J Hand Surg Am. 1999;24:1298-302 pubmed
    ..Age, gender, size, and location within the digit (volar vs. dorsal) were not risk factors for recurrence. Awareness of these associations should be reflected in the surgeon's approach and preoperative discussion with the patient...
  3. Boons H, Keijser L, Schreuder H, Pruszczynski M, Lemmens J, Veth R. Oncologic and functional results after treatment of giant cell tumors of bone. Arch Orthop Trauma Surg. 2002;122:17-23 pubmed
    ..When applying cryosurgery as the local adjuvant, more vigorous freezing may be necessary to improve local tumor control...
  4. Shiozawa M, Imada T, Ishiwa N, Rino Y, Hasuo K, Takanashi Y, et al. Osteoclast-like giant cell tumor of the pancreas. Int J Clin Oncol. 2002;7:376-80 pubmed
    ..The tumor was diagnosed as osteoclast-like giant cell tumor of the pancreas. We report this case and review 31 cases previously described in the literature...
  5. Middleton W, Patel V, Teefey S, Boyer M. Giant cell tumors of the tendon sheath: analysis of sonographic findings. AJR Am J Roentgenol. 2004;183:337-9 pubmed
    The purpose of this study was to analyze the sonographic characteristics of giant cell tumors of the tendon sheath.
  6. Dodd L, Major N, Brigman B. Malignant giant cell tumor of soft parts. Skeletal Radiol. 2004;33:295-9 pubmed
    ..The lesion recurred rapidly despite wide resection with negative surgical margins. Biopsy of the pulmonary lesions demonstrated metastatic disease...
  7. Chen C, Lee P, Han W, Shen K. Primary giant cell malignant fibrous histiocytoma of the kidney with staghorn calculi. J Postgrad Med. 2003;49:246-8 pubmed
    ..Histopathologic examination revealed malignant fibrous histiocytoma (MFH) of giant cell type. To the best of our knowledge, this is the first report of primary renal MFH associated with staghorn calculi...
  8. Ramos R, Haupt H, Kanetsky P, Donthineni Rao R, Arenas Elliott C, Lackman R, et al. Giant cell tumors: inquiry into immunohistochemical expression of CD117 (c-Kit), microphthalmia transcription factor, tartrate-resistant acid phosphatase, and HAM-56. Arch Pathol Lab Med. 2005;129:360-5 pubmed
    Osteoclast-like giant cells (GCs) in giant cell tumors (GCTs) are thought to derive from a monocyte-macrophage lineage...
  9. Dewsnup N, Susarla S, Abulikemu M, Faquin W, Kaban L, August M. Immunohistochemical evaluation of giant cell tumors of the jaws using CD34 density analysis. J Oral Maxillofac Surg. 2008;66:928-33 pubmed publisher
    ..To compare CD34 expression in both aggressive and nonaggressive giant cell lesions of the jaws and identify any associations between tumor vascular density and biologic behavior...

More Information

Publications86

  1. Dickson B, Li S, Wunder J, Ferguson P, Eslami B, Werier J, et al. Giant cell tumor of bone express p63. Mod Pathol. 2008;21:369-75 pubmed publisher
    ..Moreover, p63 may be a useful biomarker to differentiate giant cell tumor of bone from central giant cell granuloma and other giant cell-rich tumors, such as giant cell tumor of tendon sheath and pigmented villonodular synovitis...
  2. Lee C, Lee S, Lee J, Kim J, Park D, Sol M, et al. Malignant osteoclast-like giant cell tumor of the kidney with osteosarcomatous transformation. J Urol. 2003;169:272-3 pubmed
  3. Wieneke J, Gannon F, Heffner D, Thompson L. Giant cell tumor of the larynx: a clinicopathologic series of eight cases and a review of the literature. Mod Pathol. 2001;14:1209-15 pubmed
    True giant cell tumors of the larynx (GCTL) are quite rare, and only individual case reports are documented in the literature. Eight cases of GCTL were identified in the Otorhinolaryngic Pathology Tumor Registry between 1966 and 2000...
  4. Parker W, Beckenbaugh R, Amrami K. Calcifying aponeurotic fibroma of the hand: radiologic differentiation from giant cell tumors of the tendon sheath. J Hand Surg Am. 2006;31:1024-8 pubmed
  5. Möller E, Mandahl N, Mertens F, Panagopoulos I. Molecular identification of COL6A3-CSF1 fusion transcripts in tenosynovial giant cell tumors. Genes Chromosomes Cancer. 2008;47:21-5 pubmed
    Tenosynovial giant cell tumors (TGCTs) are benign lesions of the tendon sheaths that primarily affect the fingers, ankles, or feet...
  6. Bauditz J, Rudolph B, Wermke W. Osteoclast-like giant cell tumors of the pancreas and liver. World J Gastroenterol. 2006;12:7878-83 pubmed
    Osteoclast-like giant cell tumors (OGCT) are rare abdominal tumors, which mainly occur in the pancreas. The neoplasms are composed of two distinct cell populations and frequently show an inhomogenous appearance with cystic structures...
  7. Relwani J, Factor D, Khan F, Dutta A. Giant cell tumour of the patellar tendon sheath--an unusual cause of anterior knee pain: a case report. Knee. 2003;10:145-8 pubmed
    ..We present a case of a giant cell tumour of the patellar tendon sheath with anterior knee pain. The relevant MRI findings and differential diagnosis of such lesions is discussed here...
  8. Sawyer J, Goosen L, Binz R, Swanson C, Nicholas R. Evidence for telomeric fusions as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone. Cancer Genet Cytogenet. 2005;159:32-6 pubmed
    ..These findings support the concept that telomeric instability is responsible for a large degree of intratumor heterogeneity and serves as a precursor lesion to subsequent clonal structural aberrations of chromosome 11 in GCTB...
  9. Nilsson M, Hoglund M, Panagopoulos I, Sciot R, Dal Cin P, Debiec Rychter M, et al. Molecular cytogenetic mapping of recurrent chromosomal breakpoints in tenosynovial giant cell tumors. Virchows Arch. 2002;441:475-80 pubmed
    ..In four of seven cases there was a breakpoint within the sequence covered by probe 260J21, where the RDC1 gene is located, a gene reported to fuse with HMGIC in lipomas with a 2;12 translocation...
  10. Hansen T, Burg J, Kirkpatrick C, Kriegsmann J. Osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: case report with novel data on histogenesis. Pancreas. 2002;25:317-20 pubmed
  11. Moore J, Hilden K, Bentz J, Pearson R, Adler D. Osteoclastic and pleomorphic giant cell tumors of the pancreas diagnosed via EUS-guided FNA: unique clinical, endoscopic, and pathologic findings in a series of 5 patients. Gastrointest Endosc. 2009;69:162-6 pubmed publisher
    Osteoclastic and pleomorphic giant cell tumors of the pancreas are rare entities that have been typically described only in single case reports...
  12. Boer K, Jansen F, Nellist M, Redeker S, van den Ouweland A, Spliet W, et al. Inflammatory processes in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex. Epilepsy Res. 2008;78:7-21 pubmed
    Cortical tubers and subependymal giant cell tumors (SGCT) are two major cerebral lesions associated with tuberous sclerosis complex (TSC)...
  13. Fujimoto N, Nakagawa K, Seichi A, Terahara A, Tago M, Aoki Y, et al. A new bisphosphonate treatment option for giant cell tumors. Oncol Rep. 2001;8:643-7 pubmed
    Treatment of giant cell tumors (GCT) especially in the vertebrae remains controversial. With multidisciplinary treatments, their results are still insufficient...
  14. Leighton C, Shum D. Osteoclastic giant cell tumor of the pancreas: case report and literature review. Am J Clin Oncol. 2001;24:77-80 pubmed
    ..The natural history, pathologic evaluation, and clinical implications of this rare neoplasm are discussed with reference to published reports...
  15. Fellenberg J, Lehner B, Witte D. Silencing of the UCHL1 gene in giant cell tumors of bone. Int J Cancer. 2010;127:1804-12 pubmed publisher
    b>Giant cell tumors are heterogeneous tumors consisting of multinucleated giant cells, fibroblast-like stromal cells and mononuclear histiocytes...
  16. Hoang M, Rogers B, Albores Saavedra J. Giant cell tumor of the skin: a morphologic and immunohistochemical study of five cases. Ann Diagn Pathol. 2002;6:288-93 pubmed
    ..Cutaneous GCTs are low-grade sarcomas that can recur locally and infrequently metastasize. These tumors should be distinguished from a variety of cutaneous neoplasms that contain multinucleated giant cells...
  17. Holst V, Elenitsas R. Primary giant cell tumor of soft tissue. J Cutan Pathol. 2001;28:492-5 pubmed
    ..In 1989 in the dermatology literature, two malignant giant cell tumors of soft parts were described that filled the dermis and extended into the subcutaneous tissue.
  18. Fukunaga M. Giant cell tumor of the breast. Virchows Arch. 2002;441:93-5 pubmed
  19. Brandal P, Bjerkehagen B, Heim S. Molecular cytogenetic characterization of tenosynovial giant cell tumors. Neoplasia. 2004;6:578-83 pubmed
    ..The IP-FISH studies showed trisomy 7 in 56% of the tumors (15/27), whereas chromosomes 1 and 5 seemed to be disomic in all TSGCTs. All informative tumors were wild-type by microsatellite instability analysis...
  20. Nakamura S, Kusuzaki K, Murata H, Takeshita H, Hirata M, Hashiguchi S, et al. Ceramic endoprosthesis for aggressive giant cell tumors near the knee: eight cases followed for more than 10 years. Int Orthop. 2001;25:104-6 pubmed
    ..Newly formed bone appeared at the junction between implant and cortex and in 2 cases subsidence of the implant was seen. All the patients had good function of the knee and no revision was needed...
  21. Lu K. Arthroscopic excision of juxta-articular giant-cell tumor arising from the patellar tendon sheath. Arthroscopy. 2004;20:eE35-8 pubmed
    ..To the best of my knowledge, this is the first reported case of a large, localized, juxta-articular giant-cell tumor of the patellar tendon sheath that was treated successfully with arthroscopic excision...
  22. Strauss L, Dimitrakopoulou Strauss A, Koczan D, Bernd L, Haberkorn U, Ewerbeck V, et al. 18F-FDG kinetics and gene expression in giant cell tumors. J Nucl Med. 2004;45:1528-35 pubmed
    18F-FDG kinetics were evaluated by use of compartment and noncompartment models of giant cell tumors. The kinetic data were compared with the gene expression data for a subgroup of patients.
  23. Forsyth R, De Boeck G, Bekaert S, De Meyer T, Taminiau A, Uyttendaele D, et al. Telomere biology in giant cell tumour of bone. J Pathol. 2008;214:555-63 pubmed publisher
    ..Telomere maintenance could be considered an important key factor in the pathogenesis of GCTB...
  24. Fu K, Moran C, Suster S. Primary mediastinal giant cell tumors: a clinicopathologic and immunohistochemical study of two cases. Ann Diagn Pathol. 2002;6:100-5 pubmed
    Two cases of posterior mediastinal giant cell tumors are presented. The patients are a woman and a man, 31 and 18 years old, respectively. One of the patients had symptoms of paresthesias while the other was completely asymptomatic...
  25. Berendt R, Shnitka T, Wiens E, Manickavel V, Jewell L. The osteoclast-type giant cell tumor of the pancreas. Arch Pathol Lab Med. 1987;111:43-8 pubmed
    ..Zymogen granules, desmosomes, and zonulae occludentes were identified ultrastructurally and further support an epithelial derivation...
  26. Takesako H, Osaka E, Yoshida Y, Sugitani M, Tokuhashi Y. Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report. J Med Case Rep. 2016;10:47 pubmed publisher
    Malignant transformation of giant cell tumors of bones, that is, secondary malignant giant cell tumor of bone, is rare. The most common symptoms are local pain and swelling...
  27. Nielsen G, Rosenberg A, O Connell J, Kattapuram S, Schiller A. Tumors and diseases of the joint. Semin Diagn Pathol. 2011;28:37-52 pubmed
    ..These crystal deposits may be asymptomatic or cause severe pain or chronic joint destruction. Their accurate identification is important to guide appropriate therapy. ..
  28. Rekhi B, Verma V, Gulia A, Jambhekar N, Desai S, Juvekar S, et al. Clinicopathological Features of a Series of 27 Cases of Post-Denosumab Treated Giant Cell Tumors of Bones: A Single Institutional Experience at a Tertiary Cancer Referral Centre, India. Pathol Oncol Res. 2017;23:157-164 pubmed publisher
    ..Post-denosumab treated GCT cases appear as low grade osteosarcomas on histopathologic examination, but lack the clinical behaviour of an osteosarcoma, therefore may be considered as pseudo malignant bony lesions. ..
  29. Maruthainar N, Zambakidis C, Harper G, Calder D, Cannon S, Briggs T. Functional outcome following excision of tumours of the distal radius and reconstruction by autologous non-vascularized osteoarticular fibula grafting. J Hand Surg Br. 2002;27:171-4 pubmed
    ..This technique achieves a satisfactory functional result without compromise of the prognosis for the tumour. ..
  30. Khodaei I, Rowley H, Farrell M, Collins C, Vianni L, Rawluk D. An unusual cause for tinnitus. Ir Med J. 2001;94:312-3 pubmed
    ..They usually present at the epiphyses of long bones such as the proximal femur and distal radius. Otological symptoms are not known as a common presenting symptom of giant cell granulomas...
  31. Kholova I, Ryska A, Dedic K. Composite tumor consisting of dermatofibrosarcoma protuberans and giant cell fibroblastoma associated with intratumoral endometriosis. Report of a case. Pathol Res Pract. 2001;197:263-7; discussion 269-70 pubmed
    ..The presence of endometriosis within the soft tissue tumor represents, to the best of our knowledge, a previously undescribed collision phenomenon. ..
  32. Nugent M. microRNA and Bone Cancer. Adv Exp Med Biol. 2015;889:201-30 pubmed publisher
    ..limited evidence to support a role for microRNAs in other primary bone tumors, either malignant or benign; however, early work is suggestive of involvement in chondrosarcoma, multiple osteochondromatosis, and giant cell tumors of bone.
  33. Singh T, Noor S, Simons A. Multiple localized giant cell tumor of the tendon sheath (GCTTS) affecting a single tendon: a very rare case report and review of recent cases. Hand Surg. 2011;16:367-9 pubmed
    b>Giant cell tumors of the tendon sheath (GCTTS) are very common. More recently, a small number of case reports have identified the presence of multifocal GCTTS in the hand...
  34. Largo R, Jung F, Calcagni M, Jandali A. [Multicentric localised giant cell tumour of the tendon sheath on both hands with a focal infiltration of the extensor tendon: case report and review of the literature]. Handchir Mikrochir Plast Chir. 2011;43:181-5 pubmed publisher
    ..We report on the very rare occurrence of a multicentric localised giant cell tumour of the tendon sheath on both hands with a focal infiltration of the extensor tendon tissue in a 39-year-old otherwise healthy man. ..
  35. Gholve P, Hosalkar H, Kreiger P, Dormans J. Giant cell tumor of tendon sheath: largest single series in children. J Pediatr Orthop. 2007;27:67-74 pubmed
    b>Giant cell tumors of tendon sheath (GCTTS) are rare in children...
  36. Qi Z, Li C, Ma X, Li Z, Zhang K, Yu D. [Changes of 3-tesla 31P-MR spectroscopy of bone and soft tissue tumors]. Zhonghua Zhong Liu Za Zhi. 2009;31:442-6 pubmed
    ..05). Pcr/PME and PME/NTP are potential diagnostic indexes of bone and soft tissue tumors. PME/beta-ATP and PME/NTP are potential indexes of differential diagnosis of bone and soft tissue tumors. ..
  37. Wit E, Schnater J. [Diagnostic image (201). A man with a swelling of a finger due to a giant cell tumor of the tendon sheath]. Ned Tijdschr Geneeskd. 2004;148:1590 pubmed
    ..A 46-year-old man presented with a swelling of the proximal phalanx of the right index finger, due to a giant cell tumour of the tendon sheath. ..
  38. Zorlu F, Selek U, Soylemezoglu F, Oge K. Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. J Neurooncol. 2006;76:149-52 pubmed
    ..We present a case report of a giant cell tumor located in the skull base orginating from clivus and sphenoid bone treated by surgery and external beam radiotherapy (EBRT)...
  39. Rendina D, Gennari L, De Filippo G, Merlotti D, De Campora E, Fazioli F, et al. Evidence for increased clinical severity of familial and sporadic Paget's disease of bone in Campania, southern Italy. J Bone Miner Res. 2006;21:1828-35 pubmed
    ..A prevalent involvement of the spine and the skull, the sites preferentially involved in giant cell tumors complicating Paget's disease, was also shown in familial cases from this geographical region.
  40. Schaser K, Bail H, Haas N, Melcher I. [Treatment concepts of benign bone tumors and tumor-like bone lesions]. Chirurg. 2002;73:1181-90 pubmed
    ..e. complication rate, possibilities for reconstructive stabilizations and resultant functional deficits,making the decision a responsible challenge to the orthopedic surgeon. ..
  41. Chen J, Younusi A, Cao L, Tian Z, Zhou Y, Song X. Potential role of heat-shock proteins in giant cell tumors. Genet Mol Res. 2015;14:19144-54 pubmed publisher
    We investigated the differential expression protein profile of giant cell tumors (GCTs), which can be used to monitor the tumor's recurrence and metastasis, to provide preliminary results for further study...
  42. Thomas R, Banerjee S, Eyden B, Shanks J, Bisset D, Hunt R, et al. A study of four cases of extra-orbital giant cell angiofibroma with documentation of some unusual features. Histopathology. 2001;39:390-6 pubmed
    ..Giant cell angiofibroma shares many features with solitary fibrous tumour and giant cell fibroblastoma and shows a wider distribution than initially recognized. Rarely, Schwannian differentiation may be observed in these tumours. ..
  43. Kanthan R, Torkian B. Primary de novo malignant giant cell tumor of kidney: a case report. BMC Urol. 2004;4:7 pubmed
    Osteoclast-like giant cell tumors are usually observed in osseous tissue or as tumors of tendon sheath, characterized by the presence of multinucleated giant cells and mononuclear stromal cells...
  44. Kim N, Han J. Primary giant cell tumor of soft tissue. Report of a case with fine needle aspiration cytologic and histologic findings. Acta Cytol. 2003;47:1103-6 pubmed
    ..Awareness of its existence and knowledge of its cytologic features are important for a correct preoperative cytologic diagnosis. ..
  45. Yamamoto H, Iwasaki T, Yamada Y, Matsumoto Y, Otsuka H, Yoshimoto M, et al. Diagnostic utility of histone H3.3 G34W, G34R, and G34V mutant-specific antibodies for giant cell tumors of bone. Hum Pathol. 2018;73:41-50 pubmed publisher
    b>Giant cell tumors of bone (GCTBs) are characterized by mononuclear stromal cells and osteoclast-like giant cells; up to 95% have H3F3A gene mutation...
  46. Wang S, Wei X, Chen B, Zhao M, Song G, Zhang Z, et al. Expression of metabotropic glutamate receptor 4 in osteosarcoma. Mol Clin Oncol. 2016;4:65-69 pubmed
    ..05). Therefore, mGluR4 expression may be used to estimate the prognosis of osteosarcoma patients. ..
  47. Dingle S, Flynn J, Stewart G. Giant-cell tumor of the tendon sheath involving the cervical spine. A case report. J Bone Joint Surg Am. 2002;84-A:1664-7 pubmed
  48. Smith L, Mayerson J, Nowak N, Suster D, Mohammed N, Long S, et al. 20q11.1 amplification in giant-cell tumor of bone: Array CGH, FISH, and association with outcome. Genes Chromosomes Cancer. 2006;45:957-66 pubmed
    ..001) was the only factor to reach statistical significance. 20q11.1 amplification can be used as a marker of prognostic importance in GCTb. We propose TPX2 as a candidate oncogene in the core-amplified region at 20q11.1. ..
  49. Aghaloo T, Dry S, MALLYA S, Tetradis S. Stage 0 osteonecrosis of the jaw in a patient on denosumab. J Oral Maxillofac Surg. 2014;72:702-16 pubmed publisher
    ..This report describes a case of stage 0 ONJ in a patient on denosumab and indicates the full-spectrum similarities between BP- and denosumab-associated ONJ clinically, radiographically, and histologically. ..
  50. Pepper T, Falla L, Brennan P. Soft tissue giant cell tumour of low malignant potential arising in the masseter--a rare entity in the head and neck. Br J Oral Maxillofac Surg. 2010;48:149-51 pubmed publisher
    ..Because of the possibility of local recurrence, clinical follow up with or without postoperative radiotherapy is advised after excision...
  51. Kuo C, Yang S, Chou Y, Wong C. Giant cell tumor of the EDL tendon sheath: an unusual cause of hallux valgus. Foot Ankle Int. 2008;29:534-7 pubmed publisher
    ..Surgical excision of the tumor and corrective osteotomy produced a permanent cure. This unusual cause of a hallux valgus deformity should increase awareness of tumors as a possible cause of foot deformities...
  52. Li H, Pan C, Zeng H, Zeng Y, Shen X, Dong S. [Expression and significance of nitric oxide synthase mRNAs and proteins in giant cell tumors of bone]. Ai Zheng. 2003;22:1180-3 pubmed
    ..There was no report about relation of expression of NOS in giant cell tumors(GCT) of bone with its pathological grading and tumor recurrence...
  53. Van Dyck P, Vanhoenacker F, Gielen J, De Schepper A, Parizel P. Imaging of tumours of the foot and ankle. JBR-BTR. 2004;87:252-7 pubmed
    ..This presentation aims to give an overview of bone and soft-tissue tumours of the foot and ankle and to discuss the strength of each imaging modality in the diagnosis...
  54. Ulu M, Biceroglu H, Ozlen F, Oz B, Gazioglu N. Giant cell tumor of the frontal bone in an 18-month-old girl: a case report. Cent Eur Neurosurg. 2010;71:104-7 pubmed publisher
    b>Giant cell tumors (GCT) are benign, but locally aggressive primary bone neoplasms, that frequently occur in the epiphyses of the long bones...
  55. Leithner A, Weinhaeusel A, Windhager R, Schlegl R, Waldner P, Lang S, et al. Absence of SV40 in Austrian tumors correlates with low incidence of mesotheliomas. Cancer Biol Ther. 2002;1:375-9 pubmed
    ..polymerase chain reaction-based (PCR) method to search for SV40 sequences in DNA that was extracted from 14 giant cell tumors, ten osteosarcomas and eight mesotheliomas...
  56. Settakorn J, Lekawanvijit S, Arpornchayanon O, Rangdaeng S, Vanitanakom P, Kongkarnka S, et al. Spectrum of bone tumors in Chiang Mai University Hospital, Thailand according to WHO classification 2002: A study of 1,001 cases. J Med Assoc Thai. 2006;89:780-7 pubmed
    ..The aim of the present study was to determine the spectrum, frequency and demographics of bone tumors...
  57. Seethala R, Goldblum J, Hicks D, Lehman M, Khurana J, Pasha T, et al. Immunohistochemical evaluation of microphthalmia-associated transcription factor expression in giant cell lesions. Mod Pathol. 2004;17:1491-6 pubmed
    ..expressed in the monocyte-derived giant cells and/or the adjacent mononuclear cells/histiocytes in 23 (89%) giant cell tumors of the bone, 23 (96%) giant cell tumors of tendon sheath/pigmented villonodular synovitis, three (100%) ..
  58. Guo H, Garcia R, Perle M, Amodio J, Greco M. Giant cell tumor of soft tissue with pulmonary metastases: pathologic and cytogenetic study. Pediatr Dev Pathol. 2005;8:718-24 pubmed
    ..We report the case of a 12-year-old girl with GCTST of the right leg that metastasized to the lung. Cytogenetic studies from the primary tumor showed the phenomenon of telomeric association involving multiple chromosomes...
  59. Kondo R, Akiba J, Hiraoka K, Hisaoka M, Hashimoto H, Kage M, et al. Malignant diffuse-type tenosynovial giant cell tumor of the buttock. Pathol Int. 2012;62:559-64 pubmed publisher
    ..Pulmonary metastases were found 6 months after the operation. These findings indicate that this lesion is consistent with malignant D-TSGCT...
  60. Muramatsu K, Mine T, Ichihara K. Atypical tenosynovial giant cell tumor of the extensor hallucis longus tendon. J Am Podiatr Med Assoc. 2006;96:359-61 pubmed
    ..We discuss how local recurrence of this tumor could be prevented...
  61. Sandberg A, Bridge J. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. Dermatofibrosarcoma protuberans and giant cell fibroblastoma. Cancer Genet Cytogenet. 2003;140:1-12 pubmed
  62. Weitao Y, Qiqing C, Songtao G, Jiaqiang W. Use of gluteus maximus adipomuscular sliding flaps in the reconstruction of sacral defects after tumor resection. World J Surg Oncol. 2013;11:110 pubmed publisher
    ..We investigated whether defect reconstruction with gluteus maximus (GLM) adipomuscular sliding flaps would improve patient outcomes...
  63. Harness N, Mankin H. Giant-cell tumor of the distal forearm. J Hand Surg Am. 2004;29:188-93 pubmed
    ..We have studied the results from our institution for 49 patients with giant-cell tumors of the distal forearm treated from 2 to 28 years (mean, 14 +/- 7 years) and compared the results for different methods of treatment...
  64. Kusafuka K, Nakamura S, Asano R, Kamijo T, Iida Y, Onistuka T, et al. Osteoclast-type giant cell tumor of minor salivary gland with mucin-rich salivary duct carcinoma: a case report of unusual histology with immunohistochemical analysis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:870-7 pubmed publisher
    ..Salivary giant cell tumor (GCT) is exceedingly rare. This article presents an additional rare case of salivary GCT with salivary duct carcinoma (SDC)...
  65. Ravi V, Wang W, Lewis V. Treatment of tenosynovial giant cell tumor and pigmented villonodular synovitis. Curr Opin Oncol. 2011;23:361-6 pubmed publisher
    ..To review recent developments in the molecular pathogenesis of tenosynovial giant cell tumor (TGCT) or pigmented villonodular synovitis (PVNS) and its therapeutic implications...
  66. Grabellus F, von Winterfeld F, Sheu S, Metz K, Jahnke K, Schmid K. Unusual aggressive course of a giant cell tumor of soft tissue during immunosuppressive therapy. Virchows Arch. 2006;448:847-51 pubmed
    ..Therefore, we suggest that in patients with immunosuppression, even low malignant cancerous lesions should be carefully observed, as their local behavior may be aggressive with development of metastasis...
  67. Blay J, El Sayadi H, Thiesse P, Garret J, Ray Coquard I. Complete response to imatinib in relapsing pigmented villonodular synovitis/tenosynovial giant cell tumor (PVNS/TGCT). Ann Oncol. 2008;19:821-2 pubmed publisher
  68. Zanetti M, Weishaupt D. MR imaging of the forefoot: Morton neuroma and differential diagnoses. Semin Musculoskelet Radiol. 2005;9:175-86 pubmed
    ..Some diagnoses (nodules associated with rheumatoid arthritis, synovial cyst, soft tissue chondroma, and plantar fibromatosis) are rare and can be diagnosed with histologic correlation only...
  69. Singh P, Constable L, O DONNELL J. Arthroscopic excision of a giant-cell tumour of the ligamentum teres. J Bone Joint Surg Br. 2009;91:809-11 pubmed publisher
    ..The lesion was only detected at the time of hip arthroscopy despite pre-operative MRI being performed. It was successfully excised arthroscopically with resolution of the symptoms...
  70. Beccheroni A, Lucarelli E, Donati D, Sangiorgi L, Capponcelli S, Gorini M, et al. Recovery of stromal stem cells in bone sarcoma patients after chemotherapy: implication for cell-based therapy in bone defect reconstruction. Oncol Rep. 2003;10:891-6 pubmed
  71. Monaghan H, Salter D, al Nafussi A. Giant cell tumour of tendon sheath (localised nodular tenosynovitis): clinicopathological features of 71 cases. J Clin Pathol. 2001;54:404-7 pubmed
    ..The objective of this study was to review a series of cases in our department and to determine any clinical or pathological features that might predict the likelihood of recurrence...
  72. Mackie G. Pigmented villonodular synovitis and giant cell tumor of the tendon sheath: scintigraphic findings in 10 cases. Clin Nucl Med. 2003;28:881-5 pubmed
    ..Magnetic resonance imaging will often aid in the differentiation by demonstrating features of hemosiderin degradation products...
  73. Gallia G, Sciubba D, Bydon A, Suk I, Wolinsky J, Gokaslan Z, et al. Total L-5 spondylectomy and reconstruction of the lumbosacral junction. Technical note. J Neurosurg Spine. 2007;7:103-11 pubmed
    ..The authors conclude that this technique can be safely performed in appropriately selected patients with neoplasms involving L-5...
  74. Pascual A, Sanchez Martinez C, Moreno C, Burdaspal Moratilla A, López Rodriguez M, Rios L. Dermatofibrosarcoma protuberans with areas of giant cell fibroblastoma in the vulva: a case report. Eur J Gynaecol Oncol. 2010;31:685-9 pubmed
    ..To review the clinical, morphologic, immunohistochemical, and histogenetic characteristics of dermatofibrosarcoma protuberans with areas of giant cell fibroblastoma and explore current treatment options...
  75. Chechik O, Amar E, Khashan M, Morag G. Giant cell tumors in the patellar tendon area. J Knee Surg. 2010;23:115-9 pubmed
    ..We describe two cases of giant cell tumors in the patellar tendon area that were treated successfully with arthroscopically assisted complete excision...
  76. Ozerdemoğlu R, Yorgancigil H. [Total calcanectomy in a patient with a giant cell tumor]. Acta Orthop Traumatol Turc. 2003;37:79-83 pubmed
    ..A year after surgery, the patient had no complaints, and a good functional result was obtained. He was able to return to his work. No local or metastatic recurrences were encountered...
  77. Moustafa H, Riad R, Omar W, Zaher A, Ebied E. 99mTc-MIBI in the assessment of response to chemotherapy and detection of recurrences in bone and soft tissue tumours of the extremities. Q J Nucl Med. 2003;47:51-7 pubmed
    ..This prospective study is focused on the assessment of tumour response in a group of 28 bone sarcoma patients using (99m)Tc-MIBI scintigraphy...