abdominal fibromatosis

Summary

Summary: A relatively large mass of unusually firm scarlike connective tissue resulting from active participation of fibroblasts, occurring most frequently in the abdominal muscles of women who have borne children. The fibroblasts infiltrate surrounding muscle and fascia. (Stedman, 25th ed)

Top Publications

  1. Salvi P, Moles N, Gazzetti M, Lombardi A, Puzzovio A, Mongardini M. [Desmoid tumor of rectus muscle of abdomen in a woman of childbearing age: what can we do?]. G Chir. 2003;24:413-7 pubmed
    ..In women of childbearing age, even after non radical histological DT primary resection, adjunctive radiotherapy, chemotherapy or antiestrogen therapy could be avoided and clinical observation alone may be considered...
  2. Azizi L, Balu M, Belkacem A, Lewin M, Tubiana J, Arrive L. MRI features of mesenteric desmoid tumors in familial adenomatous polyposis. AJR Am J Roentgenol. 2005;184:1128-35 pubmed
  3. Jalini L, Hemming D, Bhattacharya V. Intraabdominal desmoid tumour presenting with perforation. Surgeon. 2006;4:114-6 pubmed
    ..Some unresectable tumours show oestrogen receptor positive cells and can be managed with tamoxifen. The aetiology, investigation and management options are briefly described...
  4. Colombo P, Rahal D, Grizzi F, Quagliuolo V, Roncalli M. Localized intra-abdominal fibromatosis of the small bowel mimicking a gastrointestinal stromal tumor: a case report. World J Gastroenterol. 2005;11:5226-8 pubmed
    Intra-abdominal fibromatosis (IAF) is a benign mesenchymal lesion that can occur throughout the gastrointestinal tract. Although rare, it is the most common primary tumor of the mesentery and can develop at any age...
  5. Lee J, Thomas J, Phillips S, Fisher C, Moskovic E. Aggressive fibromatosis: MRI features with pathologic correlation. AJR Am J Roentgenol. 2006;186:247-54 pubmed
    ..We present the MRI features with pathologic correlation of aggressive fibromatosis, incorporating 203 cases over a 5-year period from the Royal Marsden Hospital Sarcoma Unit database...
  6. Sturt N, Gallagher M, Bassett P, Philp C, Neale K, Tomlinson I, et al. Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation. Gut. 2004;53:1832-6 pubmed
    ..We have suggested that because families with germline mutations in this region already have the requisite change, they are more likely to develop desmoids. However, there are families with 5' germline mutations where desmoids are common...
  7. Karagulle E, Gokturk H, Turk E, Yildirim E, Kiyici H, Karakayali H. Intestinal perforation from primary intra-abdominal fibromatosis. Saudi Med J. 2007;28:639-40 pubmed
  8. Marone U, Amore A, Pezzullo L, Mozzillo N. Giant desmoid tumor of the abdominal wall associated with familial adenomatous polyposis. Tumori. 2003;89:331-2 pubmed
    ..The usefulness of complementary therapies such as radiotherapy, hormone or chemotherapy, is not entirely clear...
  9. Barrera E, García A, Ferrufino J. [Desmoid tumor: report of a case]. Rev Gastroenterol Peru. 2005;25:288-90 pubmed
    ..We presented the case of a patient who was treated of extrinsic duodenal obstruction. A compression of the third section of the duodenum was found. The diagnosis was made by pathological anatomy...

More Information

Publications62

  1. Durkin A, Korkolis D, Al Saif O, Zervos E. Full-term gestation and transvaginal delivery after wide resection of an abdominal desmoid tumor during pregnancy. J Surg Oncol. 2005;89:86-90 pubmed
  2. Singh N, Sharma R, Dorman S, Dy V. An unusual presentation of desmoid tumor in the ileum. Am Surg. 2006;72:821-4 pubmed
    ..Of all the options described, surgery with tumor-free margins has been defined as the best treatment modality...
  3. Dalén B, Geijer M, Kvist H, Bergh P, Gunterberg B. Clinical and imaging observations of desmoid tumors left without treatment. Acta Orthop. 2006;77:932-7 pubmed
    ..There have, however, been occasional case reports showing that desmoid tumors may spontaneously decrease in size or even disappear...
  4. Iwasa T, Sadamoto Y, Itaba S, Nasu T, Ihara Y, Misawa T, et al. [A case of mesenteric desmoid tumor]. Nihon Shokakibyo Gakkai Zasshi. 2007;104:804-8 pubmed
    ..The tumor derived from the mesenterium and involved the anal side of the small intestine. The tumor was removed with partial excision of the upper jejunum. The diagnosis of mesenteric desmoid tumor was confirmed, histologically...
  5. Montagliani L, Duverger V. [Desmoid tumors]. J Chir (Paris). 2008;145:20-6 pubmed
    ..The only curative treatment is wide surgical excision, but the risk of local recurrence is high. Several adjuvant or complementary treatments have been proposed and the results show promise; the authors review all these therapies...
  6. Spiridakis K, Panagiotakis G, Grigoraki M, Kokkinos I, Papadakis T, Kokkinakis T, et al. Isolated giant mesenteric fibromatosis (intra-abdominal desmoid tumors). Case report. G Chir. 2008;29:413-6 pubmed
    ..Differential diagnosis of mesenteric masses is discussed and the Authors also review the literature concerning this rare disease...
  7. Baliski C, Temple W, Arthur K, Schachar N. Desmoid tumors: a novel approach for local control. J Surg Oncol. 2002;80:96-9 pubmed
    ..Although this is an unusual problem, we instituted a prospective cohort study with neoadjuvant chemotherapy and radiation, followed by surgical resection, in an effort to improve local control...
  8. Dutt N, Sheaff M, Feakins R. Intraabdominal desmoplastic small cell tumor mimicking adenocarcinoma. A case report. Acta Cytol. 2001;45:82-5 pubmed
    ..Fine needle aspirates and washings from intraabdominal desmoplastic small cell tumors (IADSCTs) are rarely encountered by pathologists. Immunocytochemical examination of histologic material is usually necessary for a definitive diagnosis...
  9. Shatnawei A, Hamilton C, Quintini C, Steiger E, Kirby D. Use of home parenteral nutrition in patients with intra-abdominal desmoid tumors. Nutr Clin Pract. 2010;25:290-5 pubmed publisher
    ..HPN outcomes in patients with IAD tumors have not been previously reported. The aim of this study was to compare some of the nutrition parameters and complications of HPN in patients with IAD with a control group of patients on HPN...
  10. Grant R, Malinak C, Wu H, Sabo A, Tsai C. PCR amplification and DNA sequencing of SRV-2 from archived tumor tissues. Virus Res. 1995;36:187-200 pubmed
    ..nigra). A T-cell activating domain (Env residues 233-249) was 100% conserved in the SRV-2/WA isolates...
  11. Maseelall P, Robins J, Williams D, Thomas M. Stabilization and regression of a recurrent desmoid tumor with the antiestrogen toremifene. Fertil Steril. 2005;84:509 pubmed
    ..To report a case of a pelvic desmoid tumor that was treated with the antiestrogen toremifene after a failed attempt at surgical excision...
  12. Moon J, Selvaggi G, Nishida S, Levi D, Kato T, Ruiz P, et al. Intestinal transplantation for the treatment of neoplastic disease. J Surg Oncol. 2005;92:284-91 pubmed
    ..Authors reviewed single center experience of intestinal transplantation for treatment of intra-abdominal neoplastic disease...
  13. Bertario L, Russo A, Sala P, Eboli M, Giarola M, D Amico F, et al. Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. Int J Cancer. 2001;95:102-7 pubmed
    ..9; 95% CI 1.1-3.4). Our results indicate that integrating genetic and clinical data is helpful in defining subgroups of patients at higher risk for desmoids, who may benefit from specific prevention programs...
  14. Huang G, Lee H, Lee C, Chen C. Pelvic fibromatosis with massive ossification. AJR Am J Roentgenol. 2005;184:1029-30 pubmed
  15. Sinha A, Tekkis P, Neale K, Phillips R, Clark S. Risk factors predicting intra-abdominal desmoids in familial adenomatous polyposis: a single centre experience. Tech Coloproctol. 2010;14:141-6 pubmed publisher
    ..Since the morbidity and mortality due to desmoids is almost entirely attributable to IAD, we aimed to identify specifically risk factors predicting IAD development in FAP...
  16. Reis Filho J, Milanezi F, Pope L, Fillus Neto J, Schmitt F. Primary fibromatosis of the breast in a patient with multiple desmoid tumors--report of a case with evaluation of estrogen and progesterone receptors. Pathol Res Pract. 2001;197:775-9 pubmed
    ..Primary fibromatosis of the breast (PFB) is an uncommon lesion that shows histological similarities with abdominal fibromatosis (AF), and frequently poses difficulties in the differential diagnosis with other spindle cell tumors of ..
  17. Sugi M. [A case of abdominal desmoid tumor that was difficult to differentiate from urachal tumor]. Hinyokika Kiyo. 2004;50:489-92 pubmed
    ..A post-operative pathological diagnosis revealed the tumor was a desmoid abdominal wall tumor. The desmoid abdominal wall tumor was not easily differentiated preoperatively from an urachal tumor...
  18. Koh P, Loi C, Cao X, Cheah P, Ho K, Ooi B, et al. Mesenteric desmoid tumors in Singapore familial adenomatous polyposis patients: clinical course and genetic profile in a predominantly Chinese population. Dis Colon Rectum. 2007;50:75-82 pubmed
    ..This study examined the mutational profile of the adenomatous polyposis coli gene in relation to the development of desmoid tumors in familial adenomatous polyposis patients from a predominantly Chinese population...
  19. Hartley J, Church J, Gupta S, McGannon E, Fazio V. Significance of incidental desmoids identified during surgery for familial adenomatous polyposis. Dis Colon Rectum. 2004;47:334-8; discussion 339-40 pubmed
    ..The latter often are incidental findings of uncertain significance. The study was designed to describe the natural history of incidental intra-abdominal desmoid tumors with particular reference to the desmoid reaction...
  20. Kutok J, Pinkus G, Dorfman D, Fletcher C. Inflammatory pseudotumor of lymph node and spleen: an entity biologically distinct from inflammatory myofibroblastic tumor. Hum Pathol. 2001;32:1382-7 pubmed
    ..The absence of ALK kinase as detected by immunohistochemical studies in IPT of the lymph node and spleen suggests that this entity is biologically distinct from the histologically similar IMT...
  21. Klemi P, Alanen K, Hietanen S, Grenman S, Varpula M, Salmi T. Response of estrogen receptor-positive intraabdominal fibromatosis to aromatase inhibitor therapy. Obstet Gynecol. 2003;102:1155-8 pubmed
    ..Intraabdominal fibromatosis is a rare tumor-like lesion of uncertain etiology...
  22. Griever G, Van Unnik J. Fibromatosis of the abdominal wall. JBR-BTR. 2003;86:162-3 pubmed
  23. Prat A, Peralta S, Cuellar H, Ocana A. Hepatic pneumatosis as a complication of an abdominal desmoid tumor. J Clin Oncol. 2007;25:897-8 pubmed
  24. Yang J, Wang J, Zhou X, Li X, Hou Y, Zhu X. [Clinicopathologic and genetic studies of desmoid-type fibromatosis]. Zhonghua Bing Li Xue Za Zhi. 2006;35:145-50 pubmed
    ..To study the clinicopathological and genetic features of desmoid-type fibromatosis, and to investigate the feasibility of detecting trisomy 8 in formalin fixed, paraffin embedded (FFPE) tissue by fluorescence in-situ hybridization (FISH)...
  25. Giarola M, Wells D, Mondini P, Pilotti S, Sala P, Azzarelli A, et al. Mutations of adenomatous polyposis coli (APC) gene are uncommon in sporadic desmoid tumours. Br J Cancer. 1998;78:582-7 pubmed
    ..5%). In one of the latter cases, both alleles were affected. These findings indicate a limited role of the gene in the development of desmoid tumours outside FAP...
  26. Janitzky A, Porsch M, Daher M, Kuster D, Liehr U. [Aggressive fibromatosis (desmoid tumor) : A rare differential diagnosis of metastasis of renal cell carcinoma]. Urologe A. 2010;49:81-3 pubmed publisher
    ..Aggressive fibromatosis must be considered in the differential diagnosis of renal cell carcinoma metastasis. Complete resection and subsequent radiotherapy seem to be the therapy of choice...
  27. Sun L, Wu H, Zhuang Y, Guan Y. A rare case of pregnancy complicated by mesenteric mass: what does chylous ascites tell us?. World J Gastroenterol. 2007;13:1632-5 pubmed
    ..The authors report the case for its rarity and emphasize on combining clinicopathological, radiological and immunohistochemistry analysis for management of the disease...
  28. Ghidirim G, Mishin I, Gagauz I, Vozian M, Zastavnitsky G, Iakovleva I. Sporadic retroperitoneal aggressive fibromatosis: report of a case. Zentralbl Chir. 2010;135:79-82 pubmed publisher
    ..Complete surgical resection with negative pathological margins remains the first line management of these neoplasms. Careful follow-up is indicated because recurrence may occur every time after surgery...
  29. Soon J, Lau W, Seow Choen F, Cheng C. Unresectable desmoid tumours causing obstructive uropathy in familial adenomatous polyposis. Asian J Surg. 2005;28:233-7 pubmed
    ..The optimal regimen of adjuvant medical therapy is uncertain. Successful renal autotransplantation and combination chemotherapy have been tried after failure of conventional therapy...
  30. Bhattacharya B, Dilworth H, Iacobuzio Donahue C, Ricci F, Weber K, Furlong M, et al. Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions. Am J Surg Pathol. 2005;29:653-9 pubmed
    ..Most fibromatoses have diffuse nuclear staining although occasional examples only focally label...
  31. Finke N, Lae M, Lloyd R, Gehani S, Nascimento A. Sinonasal desmoplastic small round cell tumor: a case report. Am J Surg Pathol. 2002;26:799-803 pubmed
    ..This case of sinonasal desmoplastic small round cell tumor, the third reported case not associated with a serosal surface, further obscures the nature and histogenesis of this entity...
  32. Nursal T, Abbasoglu O. Sporadic hereditary pancreatic desmoid tumor: a new entity?. J Clin Gastroenterol. 2003;37:186-8 pubmed
    ..Furthermore, the cases are without an associated FAP history, which provides the first clinical clue of a possible genetic determinant in this rare disorder...
  33. Insabato L, Di Vizio D, Pettinato G. Desmoplastic small round cell tumor. Acta Cytol. 2002;46:612; author reply 612 pubmed
  34. Kabra V, Chaturvedi P, Pathak K, deSouza L. Mesenteric fibromatosis: a report of three cases and literature review. Indian J Cancer. 2001;38:133-6 pubmed
    ..Mesenteric fibromatosis is one of the rarer forms of fibromatosis. Three such cases are being presented here with a brief review of the literature...
  35. Penna C. [Management of familial polyposis coli]. J Chir (Paris). 2002;139:260-7 pubmed
    ..Endoscopic surveillance of the duodenum is essential and prophylactic duodenal resection should be considered when duodenal polyposis is extensive...
  36. Teo H, Peh W, Shek T. Case 84: desmoid tumor of the abdominal wall. Radiology. 2005;236:81-4 pubmed
  37. Jelinek J, Stelzer K, Conrad E, Bruckner J, Kliot M, Koh W, et al. The efficacy of radiotherapy as postoperative treatment for desmoid tumors. Int J Radiat Oncol Biol Phys. 2001;50:121-5 pubmed
    ..The purpose of this study was to determine if radiotherapy is a beneficial adjuvant treatment after desmoid tumor resection...
  38. Liao C, Chang W, Ko K, Kao H, Cheng M, Huang G, et al. Desmoid tumor arising in the site of previous surgery in the left lower quadrant of the abdomen. South Med J. 2010;103:162-4 pubmed
    ..Preoperative computed tomography showed a large left lower abdominal mass. Pathology showed the spindle fibroblastic cell pattern typical of desmoids...
  39. Huang K, Fu H, Shi Y, Zhou Y, DU C. Prognostic factors for extra-abdominal and abdominal wall desmoids: a 20-year experience at a single institution. J Surg Oncol. 2009;100:563-9 pubmed publisher
    ..The purpose of this study was to explore prognostic factors associated with the recurrence free survival (RFS) rate in surgically treated extra-abdominal and abdominal wall desmoids...
  40. Bertagnolli M, Morgan J, Fletcher C, Raut C, Dileo P, Gill R, et al. Multimodality treatment of mesenteric desmoid tumours. Eur J Cancer. 2008;44:2404-10 pubmed publisher
    ..When desmoids arise in the intestinal mesentery, surgical resection is seldom possible without life-altering loss of intestinal function...
  41. Riordan C, Budny P, Regan P. Pregnancy as an autologous tissue expander for closure of an abdominal-wall defect. Br J Plast Surg. 2003;56:64-6 pubmed
    ..We report the reconstruction of a complex abdominal-wall defect using expanded skin from pregnancy. Wound closure was achieved using a vertical abdominoplasty...
  42. Wijburg E, Roumen R. [Diagnostic image (217). A woman with a tumour in a caesarean section laparotomy scar]. Ned Tijdschr Geneeskd. 2004;148:2383 pubmed
    ..A 33-year-old woman presented with a growing tumour in her caesarean section laparotomv scar, due to aggressive fibromatosis: a desmoid tumour, which was excised...
  43. Lath C, Khanna P, Gadewar S, Agrawal D. Inoperable aggressive mesenteric fibromatosis with ureteric fistula. Case report and literature review. Eur J Radiol. 2006;59:117-21 pubmed
    ..Surgery provides good results in limited disease and non-surgical modalities in cases of unresectable and residual disease...
  44. Carlson J, Fletcher C. Immunohistochemistry for beta-catenin in the differential diagnosis of spindle cell lesions: analysis of a series and review of the literature. Histopathology. 2007;51:509-14 pubmed
    ..This study aimed to define the prevalence of beta-catenin positivity in desmoid tumours and other morphologically similar spindle cell neoplasms...
  45. Basu S, Nair N, Banavali S. Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal desmoids: potential clinical role of FDG-PET in the management. Br J Radiol. 2007;80:750-6 pubmed
    ..women, age range 23-35 years), among whom were three cases of deep musculoskeletal fibromatosis, one of abdominal fibromatosis (abdominal desmoid) associated with familial adenomatous polyposis (Gardner's syndrome) and one case of ..
  46. Garonzik Wang J, Leach S. Truncal sarcomas and abdominal desmoids. Surg Clin North Am. 2008;88:571-82, vi-vii pubmed publisher
    ..A multidisciplinary approach to these entities therefore is critical to select appropriate therapeutic strategies for individual patients...
  47. Stalinska L, Turant M, Tosik D, Sygut J, Kulig A, Kopczynski J, et al. Analysis of pRb, p16INK4A proteins and proliferating antigens: PCNA, Ki-67 and MCM5 expression in aggressive fibromatosis (desmoid tumor). Histol Histopathol. 2009;24:299-308 pubmed publisher
    ..The noted levels of pRb and p16 expression in desmoid cells reflect their function in cell cycle regulation. Probably the unsettled cell cycle progression, especially in G1 phase, is not the cause of aggressive fibromatosis pathogenesis...
  48. Hansmann A, Adolph C, Vogel T, Unger A, Moeslein G. High-dose tamoxifen and sulindac as first-line treatment for desmoid tumors. Cancer. 2004;100:612-20 pubmed
    ..In the current study, high doses of tamoxifen in combination with sulindac were used to treat severe desmoid tumors to avoid surgery...
  49. Biasco G, Pantaleo M, Nobili E, Monti C. Spontaneous regression of a desmoid intraabdominal tumor in a patient affected by familial adenomatous polyposis. Am J Gastroenterol. 2004;99:1621-2 pubmed
  50. Brenner P, Rammelt S. Abdominal wall and foot reconstruction after extensive desmoid tumor resection with free tissue transfer. Langenbecks Arch Surg. 2002;386:592-7 pubmed
    ..Desmoid tumors are rare connective tissue tumors, also referred to as deep, aggressive fibromatosis. Although histologically benign, they show an invasive growth behavior and have a high local recurrence rate...
  51. Poritz L, Blackstein M, Berk T, Gallinger S, McLeod R, Cohen Z. Extended follow-up of patients treated with cytotoxic chemotherapy for intra-abdominal desmoid tumors. Dis Colon Rectum. 2001;44:1268-73 pubmed
    ..Cytotoxic chemotherapy can achieve a good initial response in inoperable desmoid tumors that have caused progressive obstruction of the gastrointestinal and urinary tracts and have caused unrelenting pain...
  52. Lefevre J, Parc Y, Kerneis S, Goasguen N, Benis M, Parc R, et al. Risk factors for development of desmoid tumours in familial adenomatous polyposis. Br J Surg. 2008;95:1136-9 pubmed publisher
    ..Desmoid tumours (DTs) are the primary cause of death of patients with familial adenomatous polyposis (FAP) following restorative proctocolectomy. The aim of this study was to identify risk factors for DT in a French population...
  53. Fujita K, Sugao H, Tsujikawa K, Itoh Y. Desmoid tumor in a scar from radical nephrectomy for renal cancer. Int J Urol. 2003;10:274-5 pubmed
    ..The possibility of desmoid tumors developing in the incised abdominal wall should be considered while following patients after surgery...