fibroadenoma

Summary

Summary: An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)

Top Publications

  1. Kuijper A, Mommers E, van der Wall E, van Diest P. Histopathology of fibroadenoma of the breast. Am J Clin Pathol. 2001;115:736-42 pubmed
    ..Hyperplasia (excluding mild hyperplasia) within the fibroadenoma was found in 32.3% of cases. Carcinoma in situ (CIS; 5 ductal, 3 lobular) was found in 8 fibroadenomas (2...
  2. Mori I, Han B, Wang X, Taniguchi E, Nakamura M, Nakamura Y, et al. Mastopathic fibroadenoma of the breast: a pitfall of aspiration cytology. Cytopathology. 2006;17:233-8 pubmed
    To assess the correlation between cytological diagnoses and histological subtypes of fibroadenoma (FA) and to clarify the cytological features of a specific group of FA displaying variable features similar to fibrocystic disease (..
  3. Lucas E, Branton P, Mecklenburg F, Moawad G. Ectopic breast fibroadenoma of the vulva. Obstet Gynecol. 2009;114:460-2 pubmed publisher
    ..Extramammary tissue is susceptible to similar benign and malignant changes seen in the breast. Some patients with ectopic breast lesions may harbor an underlying urinary tract anomaly...
  4. Kuroda H, Takeuchi I, Ohnishi K, Sakamoto G, Akiyama F, Toyozumi Y, et al. Clinical and pathologic features of fibroadenoma of the mastopathic type. Surg Today. 2006;36:590-5 pubmed
    b>Fibroadenoma with mastopathic change (FAM) is a relatively uncommon subtype of fibroadenoma of the breast, with a high incidence of pathological misdiagnosis. This histological subtype remains poorly understood because of its rarity...
  5. Sapino A, Bosco M, Cassoni P, Castellano I, Arisio R, Cserni G, et al. Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast. Mod Pathol. 2006;19:599-606 pubmed
    ..Conversely, the older age of patients with ER-beta-rich phyllodes tumors suggests that mechanisms, probably independent from estrogen stimulation, act on the growth of these tumors...
  6. Ciralik H, Bulbuloglu E, Arican O, Citil R. Fibroadenoma of the ectopic breast of the axilla--a case report. Pol J Pathol. 2006;57:209-11 pubmed
    ..In the ectopic breast tissue any disease can develop that affects the normal breast, including fibroadenoma. We reported a case of fibroadenoma of the axilla in a 23-year-old woman...
  7. Mridha A, Iyer V, Kapila K, Verma K. Value of scoring system in classification of proliferative breast disease on fine needle aspiration cytology. Indian J Pathol Microbiol. 2006;49:334-40 pubmed
    ..Sixty two patients (14 cases of fibroadenoma, 15 cases of fibroadenoma with atypia, 11 cases of proliferative breast disease (PBD), 8 cases of PBD with ..
  8. Jayasinghe Y, Simmons P. Fibroadenomas in adolescence. Curr Opin Obstet Gynecol. 2009;21:402-6 pubmed publisher
    ..This review discusses an approach to investigation and management of fibroadenomas in adolescents...
  9. Gallegos B, Perez Campos E, Martinez R, Leyva P, Martinez M, Hernandez R, et al. O-glycosylation expression in fibroadenoma. Prep Biochem Biotechnol. 2010;40:1-12 pubmed publisher
    ..With this in mind, we evaluated the expression of glycans in fibroadenoma tissue through immunohistochemistry with antibodies against mucin epitopes (Anti CA15-3 and MUC1), as well as ..

More Information

Publications62

  1. Ko M, Jung W, Cha E, Choi H. A rare case of recurrent myoid hamartoma mimicking malignancy: imaging appearances. Korean J Radiol. 2010;11:683-6 pubmed publisher
    ..Although the mammographic and ultrasonographic findings have long been described in the literature, MR finding with a dynamic study has not, to the best of our knowledge, been reported previously...
  2. Kato F, Omatsu T, Matsumura W, Takahashi M, Hosoda M, Takahashi H, et al. Dynamic MR findings of ductal carcinoma in situ within a fibroadenoma. Magn Reson Med Sci. 2011;10:129-32 pubmed
    We report magnetic resonance (MR) imaging findings of ductal carcinoma in situ (DCIS) within a fibroadenoma in a 42-year-old woman. Dynamic MR imaging revealed the mass to have 2 components with different kinetics...
  3. Adamietz B, Kahmann L, Fasching P, Schulz Wendtland R, Uder M, Beckmann M, et al. Differentiation between phyllodes tumor and fibroadenoma using real-time elastography. Ultraschall Med. 2011;32 Suppl 2:E75-9 pubmed publisher
    ..The elastic characteristics of both tumors were examined using real-time elastography (RTE) to find specific patterns that make differentiation possible...
  4. Rao S, Latha P, Ravi A, Thanka J. Ductal carcinoma in a multiple fibroadenoma: diagnostic inaccuracies. J Cancer Res Ther. 2010;6:385-7 pubmed publisher
    We present the diagnostic inaccuracies encountered in a case of multiple fibroadenoma with malignant transformation...
  5. Liu H, Yeh M, Lin K, Huang C, Hung C, Chen Y. Bloody nipple discharge in an adolescent girl: unusual presentation of juvenile fibroadenoma. Pediatr neonatol. 2010;51:190-2 pubmed publisher
    b>Fibroadenoma accounts for 50-60% of all breast mass lesions in adolescents. It usually presents as a unilateral palpable breast mass. In contrast, bloody nipple discharge rarely occurs in childhood...
  6. Bode M, Rissanen T, Apaja Sarkkinen M. Ultrasonography and core needle biopsy in the differential diagnosis of fibroadenoma and tumor phyllodes. Acta Radiol. 2007;48:708-13 pubmed
    ..The diagnosis of phyllodes tumors of the breast is challenging due to many similarities with common fibroadenomas...
  7. Yamaguchi R, Tanaka M, Mizushima Y, Hirai Y, Yamaguchi M, Kaneko Y, et al. Myxomatous fibroadenoma of the breast: correlation with clinicopathologic and radiologic features. Hum Pathol. 2011;42:419-23 pubmed publisher
    b>Fibroadenoma is a frequently encountered benign tumor that must be differentiated from carcinoma. Fibroadenomas often exhibit myxedematous changes (myxomatous fibroadenoma)...
  8. Babarović E, Zamolo G, Mustac E, Strcic M. High grade angiosarcoma arising in fibroadenoma. Diagn Pathol. 2011;6:125 pubmed publisher
    ..Here we present a case of a 53 year old, postmenopausal women with primary angiosarcoma arising in fibroadenoma. To our knowledge, this is the first case described in the literature to date.
  9. Tiu C, Chou Y, Chiou S, Hsu C, Chen S, Chiang H, et al. Development of a carcinoma in situ in a fibroadenoma: color Doppler sonographic demonstration. J Ultrasound Med. 2006;25:1335-8 pubmed
  10. Chung A, Scharre K, Wilson M. Intraductal fibroadenomatosis: an unusual variant of fibroadenoma. Breast J. 2008;14:193-5 pubmed publisher
    We present a case of a benign breast lesion that contains histopathologic characteristics of fibroadenoma, phyllodes tumor, intraductal adenoma and papilloma...
  11. Cummings M, Da Silva L, Papadimos D, Lakhani S. Fibroadenoma and intraduct papilloma--a common pathogenesis?. Virchows Arch. 2009;455:271-5 pubmed publisher
    ..That fibroadenoma and intraduct papilloma may have a common pathogenesis is discussed.
  12. Shin S, Rosen P. Bilateral presentation of fibroadenoma with digital fibroma-like inclusions in the male breast. Arch Pathol Lab Med. 2007;131:1126-9 pubmed
    ..bodies in stromal cells identical to those seen in infantile digital fibromatosis were identified in one fibroadenoma. To the best of our knowledge, this is the first reported case of bilaterally occurring fibroadenomas in the ..
  13. Yuen S, Uematsu T, Kasami M. Two cases of small infiltrating lobular carcinomas mimicking fibroadenoma on breast MRI. Breast J. 2007;13:616-7 pubmed
  14. Liu H, Chang Y, Chen C, Yang A. Facial apocrine fibroadenoma in man: a rare finding. Am J Dermatopathol. 2007;29:274-8 pubmed
    Apocrine fibroadenoma (AFA), considered a counterpart of fibroadenoma of breast, is a rare cutaneous apocrine neoplasm occurring almost exclusively in women...
  15. Doganavsargil B, Akalin T, Ylmaz M, Kandiloglu G. Perianal fibroadenoma, case report. Am J Dermatopathol. 2008;30:81-3 pubmed publisher
    ..Microscopically, it was identical to mammary fibroadenoma and composed of concurrent glandular and stromal elements...
  16. Gobbi D, Dall Igna P, Alaggio R, Nitti D, Cecchetto G. Giant fibroadenoma of the breast in adolescents: report of 2 cases. J Pediatr Surg. 2009;44:e39-41 pubmed publisher
    Giant fibroadenoma (GF) is an uncommon variant of fibroadenomas that represent the most frequent breast lesion in adolescents and young women...
  17. Tajima S, Kanemaki Y, Kurihara Y, Okamoto K, Shimamoto H, Okazaki H, et al. A case of a fibroadenoma coexisting with an invasive lobular carcinoma in the breast. Breast Cancer. 2011;18:319-23 pubmed publisher
    A case of a fibroadenoma coexisting with an invasive lobular carcinoma of the breast in a 60-year-old female is presented, and its pathological features are correlated with high-resolution magnetic resonance imaging (HR-MRI) and other ..
  18. Nakagawa M, Miyati T, Hayashi T, Kanao S, Taniguchi M, Higashimura K, et al. [Triexponential diffusion analysis in invasive ductal carcinoma and fibroadenoma]. Nihon Hoshasen Gijutsu Gakkai Zasshi. 2014;70:199-205 pubmed
    ..Eighteen subjects [10 with invasive ductal carcinoma (IDC), 8 with fibroadenoma] were evaluated using DWI with multiple b-values...
  19. Kabat G, Jones J, Olson N, Negassa A, Duggan C, Ginsberg M, et al. A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer. Cancer Causes Control. 2010;21:821-8 pubmed publisher
  20. Petersson F, Tan P, Putti T. Low-grade ductal carcinoma in situ and invasive mammary carcinoma with columnar cell morphology arising in a complex fibroadenoma in continuity with columnar cell change and flat epithelial atypia. Int J Surg Pathol. 2010;18:352-7 pubmed publisher
    ..a small low-grade invasive mammary carcinoma with cytomorphological columnar cell features arising in a complex fibroadenoma that in addition to sclerosing adenosis, apocrine metaplasia, and usual ductal hyperplasia also displayed ..
  21. Smith G, Burrows P. Ultrasound diagnosis of fibroadenoma - is biopsy always necessary?. Clin Radiol. 2008;63:511-5; discussion 516-7 pubmed publisher
    To review the ultrasound characteristics of fibroadenoma and the necessity to biopsy all fibroadenomas in the under 25 years age group.
  22. Ryan J, Curran C, Hennessy E, Newell J, Morris J, Kerin M, et al. The sodium iodide symporter (NIS) and potential regulators in normal, benign and malignant human breast tissue. PLoS ONE. 2011;6:e16023 pubmed publisher
    ..This study aimed to quantify relative expression of NIS and putative regulators in human breast tissue, with relationships observed further investigated in vitro...
  23. Ooe A, Takahara S, Sumiyoshi K, Yamamoto H, Shiba E, Kawai J. Preoperative diagnosis of ductal carcinoma in situ arising within a mammary fibroadenoma: a case report. Jpn J Clin Oncol. 2011;41:918-23 pubmed publisher
    b>Fibroadenoma is the most common form of benign breast tumor and the most common breast tumor in women under 30 years of age. However, carcinoma arising within a fibroadenoma is unusual, with over 100 cases reported in the literature...
  24. de Lima C, de Arimatéa dos Santos Junior J, Nazário A, Michelacci Y. Changes in glycosaminoglycans and proteoglycans of normal breast and fibroadenoma during the menstrual cycle. Biochim Biophys Acta. 2012;1820:1009-19 pubmed
    b>Fibroadenoma is the most common breast tumor in young women, and its growth and metabolism may be under hormonal control...
  25. Luo J, Liu Y, Zhang X, Shi L. [Application of diffusion weighted magnetic resonance imaging to differential diagnosis of breast diseases]. Ai Zheng. 2007;26:168-71 pubmed
    ..This study was to investigate the value of DWI in differentiating benign and malignant breast lesions...
  26. Park C, David L, Argenta L. Breast asymmetry: presentation of a giant fibroadenoma. Breast J. 2006;12:451-61 pubmed
    ..The differential diagnosis, evaluation modalities, and treatment options of breast asymmetry and unilateral breast masses are presented. Postexcision breast reconstruction is discussed...
  27. Kazakov D, Spagnolo D, Stewart C, Thompson J, Agaimy A, Magro G, et al. Fibroadenoma and phyllodes tumors of anogenital mammary-like glands: a series of 13 neoplasms in 12 cases, including mammary-type juvenile fibroadenoma, fibroadenoma with lactation changes, and neurofibromatosis-associated pseudoangiomatous stromal h. Am J Surg Pathol. 2010;34:95-103 pubmed publisher
    ..5 to 4.5 cm. Microscopically, 8 lesions were classified as fibroadenoma, and 5, including 1 recurrent tumor, as phyllodes tumor, of which 1 was benign and 4 low-grade malignant...
  28. Yamaguchi R, Tanaka M, Yokoyama T, Nonaka Y, Mizushima Y, Kawahara A, et al. Cytological features of myxomatous fibroadenoma of the breast. Diagn Cytopathol. 2012;40:316-20 pubmed publisher
    b>Fibroadenoma (FA) is a benign tumor that must be differentiated from carcinomas. FAs often exhibit myxedematous changes (myxomatous FA, M-FA). We previously reported on the clinical significance of M-FA...
  29. Kazakov D, Spagnolo D, Kacerovska D, Michal M. Lesions of anogenital mammary-like glands: an update. Adv Anat Pathol. 2011;18:1-28 pubmed publisher
    ..This will enable their recognition, precise classification and should introduce greater uniformity in how they are reported in the literature so that more meaningful clinicopathological comparisons and correlations may be made...
  30. Skenderi F, Krakonja F, Vranic S. Infarcted fibroadenoma of the breast: report of two new cases with review of the literature. Diagn Pathol. 2013;8:38 pubmed publisher
    ..Infarction can exceptionally occur as a complication of previous fine-needle aspiration biopsy or during lactation and pregnancy...
  31. Selman H, Gentile V, Pacchiarotti A, Milazzo G, Lanzilotti G, Lofino S, et al. First case of transformation for breast fibroadenoma to high-grade malignant phyllodes tumor in an in vitro fertilization patient: misdiagnosis of recurrence, treatment and review of the literature. Eur Rev Med Pharmacol Sci. 2013;17:2495-8 pubmed
    ..Cystosarcoma phyllodes are very rare tumors and may be difficult to diagnose clinically...
  32. Borecky N, Rickard M. Preoperative diagnosis of carcinoma within fibroadenoma on screening mammograms. J Med Imaging Radiat Oncol. 2008;52:64-7 pubmed publisher
    Three cases of fibroadenoma associated with carcinoma are reported...
  33. Huang K, Dobrovic A, Yan M, Karim R, Lee C, Lakhani S, et al. DNA methylation profiling of phyllodes and fibroadenoma tumours of the breast. Breast Cancer Res Treat. 2010;124:555-65 pubmed publisher
    ..001). In conclusion, assessment of methylation of RASSF1A and TWIST1 may aid in the diagnosis of phyllodes tumours. The absence of frequent methylation in fibroadenomas supports a non-neoplastic origin...
  34. El Hag I, Aodah A, Kollur S, Attallah A, Mohamed A, al Hussaini H. Cytological clues in the distinction between phyllodes tumor and fibroadenoma. Cancer Cytopathol. 2010;118:33-40 pubmed publisher
    Fine-needle aspiration (FNA) sensitivity in discriminating between phyllodes tumor and its benign mimicker fibroadenoma (FA) remains low...
  35. Corder E, Hefler L. Multilocus genotypes spanning estrogen metabolism associated with breast cancer and fibroadenoma. Rejuvenation Res. 2006;9:56-60 pubmed
    ..Three latent classification GoM extreme type groups represented the data: (a) fibroadenoma, and infrequent SRD5A2 and VDR alleles; (b) postmenopausal breast cancer, and infrequent CYP1A1-1 and CYP1A1-2 ..
  36. Wang Z, Buraimoh A, Iglehart J, Richardson A. Genome-wide analysis for loss of heterozygosity in primary and recurrent phyllodes tumor and fibroadenoma of breast using single nucleotide polymorphism arrays. Breast Cancer Res Treat. 2006;97:301-9 pubmed
    ..In contrast to fibroadenoma, phyllodes tumors can recur and be locally aggressive or be malignant...
  37. Yamaguchi R, Futamata Y, Yoshimura F, Murakami N, Koufuji K, Kutami R, et al. Mastopathic-type fibroadenoma and ductal adenoma of the breast with false-positive fluorodeoxyglucose positron emission tomography. Jpn J Radiol. 2009;27:280-4 pubmed publisher
    ..5 on PET. It was diagnosed as fibroadenoma of mastopathic type histopathologically by excisional biopsy...
  38. Khoo J, Alwi R, Abd Rahman I. Myoid hamartoma of breast with chondroid metaplasia: a case report. Malays J Pathol. 2009;31:77-80 pubmed
    ..Core needle biopsy was reported as fibroadenoma. The lesion was excised...
  39. Shin J, Choi H, Lee S, Kim Y. Microinvasive ductal carcinoma arising within a fibroadenoma: A case report. Acta Radiol. 2006;47:643-5 pubmed
    ..We report the imaging findings of a microinvasive ductal carcinoma arising within a fibroadenoma in a 51-year-old woman...
  40. Kollur S, El Hag I. FNA of breast fibroadenoma: observer variability and review of cytomorphology with cytohistological correlation. Cytopathology. 2006;17:239-44 pubmed
    To determine the observer variability in reporting fibroadenoma of the breast by fine needle aspiration (FNA) and to review the cytomorphological features of the lesion with cytohistological correlation.
  41. Berger F, Unterholzner S, Diebold J, Knesewitsch P, Hahn K, Spitzweg C. Mammary radioiodine accumulation due to functional sodium iodide symporter expression in a benign fibroadenoma. Biochem Biophys Res Commun. 2006;349:1258-63 pubmed
    ..CT and MR-mammography showed a focal solid lesion in the right breast suggestive of a fibroadenoma, which was confirmed by histological examination...
  42. Choi W, Tadros T, Majmudar B. Anal fibroadenoma: report of a common tumor type in an unusual location. South Med J. 2007;100:914-5 pubmed
  43. Weind K, Maier C, Rutt B, Moussa M. Invasive carcinomas and fibroadenomas of the breast: comparison of microvessel distributions--implications for imaging modalities. Radiology. 1998;208:477-83 pubmed
    ..To compare spatial patterns of blood vessels between invasive breast carcinomas and fibroadenomas to improve the diagnostic specificity of noninvasive vascular magnetic resonance imaging and color Doppler ultrasound...
  44. Gordon P, Gagnon F, Lanzkowsky L. Solid breast masses diagnosed as fibroadenoma at fine-needle aspiration biopsy: acceptable rates of growth at long-term follow-up. Radiology. 2003;229:233-8 pubmed
    To determine what growth rate is acceptable before recommending histologic diagnosis of solid breast lesions diagnosed as fibroadenoma at fine-needle aspiration biopsy (FNAB).
  45. Stehr K, Lebeau A, Stehr M, Grantzow R. Fibroadenoma of the breast in an 11-year-old girl. Eur J Pediatr Surg. 2004;14:56-9 pubmed
    b>Fibroadenoma is the main cause of unilateral breast mass in teenagers and adolescents. 4% of these are a special form described as giant or juvenile fibroadenoma. For primary diagnosis, ultrasound is the method of choice...
  46. Kinoshita T, Yashiro N, Ihara N, Funatu H, Fukuma E, Narita M. Diffusion-weighted half-Fourier single-shot turbo spin echo imaging in breast tumors: differentiation of invasive ductal carcinoma from fibroadenoma. J Comput Assist Tomogr. 2002;26:1042-6 pubmed
    The purpose of this investigation is to evaluate the usefulness of diffusion-weighted half-Fourier single-shot turbo spin echo (DW-HASTE) imaging in differentiating invasive ductal carcinoma from fibroadenoma.
  47. Ng W. Fine needle aspiration cytology of fibroadenoma with multinucleated stromal giant cells. A review of cases in a six-year period. Acta Cytol. 2002;46:535-9 pubmed
    To describe the fine needle aspiration cytology findings of fibroadenoma with multinucleated stromal giant cells, with histologic correlation.
  48. Jamal A. Pattern of breast diseases in a teaching hospital in Jeddah, Saudi Arabia. Saudi Med J. 2001;22:110-3 pubmed
    ..Also to compare 8 studies of literature discussing the profile of malignant and benign female breast diseases in the Kingdom. We hope that this study will assist us to appreciate the prototype breast diseases in our region...
  49. Georgian Smith D, Kricun B, McKee G, Yeh E, Rafferty E, D Alessandro H, et al. The mammary hamartoma: appreciation of additional imaging characteristics. J Ultrasound Med. 2004;23:1267-73 pubmed
  50. Stafyla V, Kotsifopoulos N, Grigoriades K, Kassaras G, Sakorafas G. Lobular carcinoma in situ of the breast within a fibroadenoma. A case report. Gynecol Oncol. 2004;94:572-4 pubmed
    b>Fibroadenoma is a benign breast tumor that is effectively treated by local excision. Although uncommon, breast fibroadenoma may harbor breast carcinoma, either in situ or invasive.
  51. Liney G, Gibbs P, Hayes C, Leach M, Turnbull L. Dynamic contrast-enhanced MRI in the differentiation of breast tumors: user-defined versus semi-automated region-of-interest analysis. J Magn Reson Imaging. 1999;10:945-9 pubmed
    ..J. Magn. Reson. Imaging 1999; 10:945-949...
  52. Edwards M, Broadwater R, Tafra L, Jarowenki D, Mabry C, Beitsch P, et al. Progressive adoption of cryoablative therapy for breast fibroadenoma in community practice. Am J Surg. 2004;188:221-4 pubmed
    ..Cryoablation is a recent technological advance and has been used for the percutaneous treatment of breast fibroadenomas. Herein, we provide a retrospective summary of the early experience from a nationwide group...
  53. Jung Y, Lee K, Yoon T, Kim M, Yim H, Kim Y, et al. Juvenile fibroadenoma in 13-month-old female child. J Paediatr Child Health. 2005;41:78-9 pubmed