clear cell sarcoma

Summary

Summary: A sarcoma of young, often female, adults of the lower extremities and acral regions, intimately bound to tendons as circumscribed but unencapsulated melanin-bearing tumors of neuroectodermal origin. An ultrastructural finding simulates flattened and curved barrel staves, corresponding to the internal structures of premelanosomes. There is a 45-60% mortality in clear cell sarcoma. (Segen, Dictionary of Modern Medicine, 1992)

Top Publications

  1. Takahira T, Oda Y, Tamiya S, Yamamoto H, Kawaguchi K, Kobayashi C, et al. Alterations of the p16INK4a/p14ARF pathway in clear cell sarcoma. Cancer Sci. 2004;95:651-5 pubmed
    b>Clear cell sarcoma (CCS) is a very rare soft tissue sarcoma with a poor prognosis. It has become apparent through immunohistochemical, ultrastructural, and microarray analyses that CCS is a soft tissue melanocytic neoplasm...
  2. Joo M, Chang S, Kim H, Gardner J, Ro J. Primary gastrointestinal clear cell sarcoma: report of 2 cases, one case associated with IgG4-related sclerosing disease, and review of literature. Ann Diagn Pathol. 2009;13:30-5 pubmed publisher
    b>Clear cell sarcoma (CCS) is a distinctive soft tissue sarcoma that shows melanocytic differentiation...
  3. Patel R, Downs Kelly E, Weiss S, Folpe A, Tubbs R, Tuthill R, et al. Dual-color, break-apart fluorescence in situ hybridization for EWS gene rearrangement distinguishes clear cell sarcoma of soft tissue from malignant melanoma. Mod Pathol. 2005;18:1585-90 pubmed
    b>Clear cell sarcoma of soft tissue (malignant melanoma of soft parts) is a soft tissue sarcoma with melanocytic differentiation that typically occurs in the tendons and aponeuroses of young adults...
  4. Hadley G, Sheik Gafoor M. Clear cell sarcoma of the kidney in children: experience in a developing country. Pediatr Surg Int. 2010;26:345-8 pubmed publisher
    b>Clear cell sarcoma of the kidney (CCSK) is a rare tumour comprising 4% of primary renal tumours in children...
  5. Granter S, Weilbaecher K, Quigley C, Fletcher C, Fisher D. Clear cell sarcoma shows immunoreactivity for microphthalmia transcription factor: further evidence for melanocytic differentiation. Mod Pathol. 2001;14:6-9 pubmed
    ..investigated the sensitivity of D5, an anti-microphthalmia transcription factor antibody, for diagnosis of clear cell sarcoma (also known as malignant melanoma of soft parts)...
  6. Boo Y, Fisher J, Haley M, Cowles R, Kandel J, Yamashiro D. Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review. J Pediatr Surg. 2009;44:2031-6 pubmed publisher
    b>Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney...
  7. Ferrari A, Casanova M, Bisogno G, Mattke A, Meazza C, Gandola L, et al. Clear cell sarcoma of tendons and aponeuroses in pediatric patients: a report from the Italian and German Soft Tissue Sarcoma Cooperative Group. Cancer. 2002;94:3269-76 pubmed
    b>Clear cell sarcoma (CCS) of tendons and aponeuroses is extremely rare in childhood and little information is available on its clinical management...
  8. Jacobs I, Chang C, Guzman G, Salti G. Clear cell sarcoma: an institutional review. Am Surg. 2004;70:300-3 pubmed
    b>Clear cell sarcoma of the tendons and aponeuroses (CCSTA) is an aggressive, rare soft-tissue tumor representing approximately 1 per cent of all soft tissue sarcomas...
  9. van Akkooi A, Verhoef C, van Geel A, Kliffen M, Eggermont A, De Wilt J. Sentinel node biopsy for clear cell sarcoma. Eur J Surg Oncol. 2006;32:996-9 pubmed
    b>Clear cell sarcoma (CCS), also known as clear cell sarcoma of tendons and aponeuroses or malignant melanoma of soft tissue, is a rare malignant tumor and is histogenitically related to melanoma...

More Information

Publications62

  1. Balarezo F, Joshi V. Clear cell sarcoma of the pediatric kidney: detailed description and analysis of variant histologic patterns of a tumor with many faces. Adv Anat Pathol. 2001;8:98-108 pubmed
    b>Clear cell sarcoma of the kidney is the most frequently misdiagnosed renal tumor in children. The majority of tumors present the classic histologic pattern, which allows a definitive diagnosis...
  2. Wang W, Mayordomo E, Zhang W, Hernandez V, Tuvin D, Garcia L, et al. Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts). Mod Pathol. 2009;22:1201-9 pubmed publisher
    Unlike melanoma, clear cell sarcoma harbors either a t(12;22)(q13;q12) recurrent translocation, resulting in an EWSR1/ATF1 chimeric gene, or less commonly a t(2;22)(q34;q12) translocation fusing EWSR1 and CREB1...
  3. Inaoka T, Takahashi K, Tandai S, Miyokawa N, Abe Y, Matsuno T, et al. Primary clear cell sarcoma (malignant melanoma) in the right radius. Skeletal Radiol. 2003;32:594-7 pubmed
    b>Clear cell sarcoma (malignant melanoma) originating in bone is an extremely rare occurrence, which has been reported twice previously...
  4. Venkataraman G, Quinn A, Williams J, Hammadeh R. Clear cell sarcoma of the small bowel: a potential pitfall. Case report. APMIS. 2005;113:716-9 pubmed
    b>Clear cell sarcoma (soft-part melanoma) is a very rare entity with a distinctive histopathologic and molecular profile...
  5. Moritake H, Sugimoto T, Asada Y, Yoshida M, Maehara Y, Epstein A, et al. Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene. Cancer Genet Cytogenet. 2002;135:48-56 pubmed
    b>Clear cell sarcoma (CCS), malignant melanoma of soft parts, is a rare malignant tumor with a poor prognosis...
  6. Nishida Y, Yamada Y, Tsukushi S, Shibata S, Ishiguro N. Sentinel lymph node biopsy reveals a positive popliteal node in clear cell sarcoma. Anticancer Res. 2005;25:4413-6 pubmed
    b>Clear cell sarcoma of the tendons and aponeuroses is an aggressive, rare soft tissue tumor with frequent metastases to regional lymph nodes...
  7. Rau A, Kini H, Verghese R. Tigroid background in fine-needle aspiration cytology of clear cell sarcoma. Diagn Cytopathol. 2006;34:355-7 pubmed
    ..quot; Though this tigroid background is a nonspecific feature and has been described in various other tumors, to the best of our knowledge, it has not been described in CCS. This feature may be useful in the recognition of CCS...
  8. Cutcliffe C, Kersey D, Huang C, Zeng Y, Walterhouse D, Perlman E. Clear cell sarcoma of the kidney: up-regulation of neural markers with activation of the sonic hedgehog and Akt pathways. Clin Cancer Res. 2005;11:7986-94 pubmed
    b>Clear cell sarcoma of the kidney (CCSK), the second most common renal tumor in children, poses significant diagnostic challenges. No positive diagnostic markers are available, and the pathogenesis of CCSK remains an enigma...
  9. Meis Kindblom J. Clear cell sarcoma of tendons and aponeuroses: a historical perspective and tribute to the man behind the entity. Adv Anat Pathol. 2006;13:286-92 pubmed
    b>Clear cell sarcoma of tendons and aponeuroses is a unique sarcoma initially described by Dr Franz M. Enzinger...
  10. Hersekli M, Ozkoc G, Bircan S, Akpinar S, Ozalay M, Tuncer I, et al. Primary clear cell sarcoma of rib. Skeletal Radiol. 2005;34:167-70 pubmed
    b>Clear cell sarcoma (malignant melanoma of soft tissues) is a very rare soft tissue neoplasm. It generally arises in tendons and aponeuroses...
  11. Salem Shabb N, Boulos F, Tawil A, Hussein M, Hourani M. Clear cell sarcoma (malignant melanoma of soft parts): fine-needle aspiration cytology of a highly pigmented tumor. Diagn Cytopathol. 2003;28:313-5 pubmed
    Diagnosis of clear cell sarcoma by fine-needle aspiration is difficult, as melanin is usually absent. Here we describe a case of a primary clear cell carcinoma with abundant melanin, making diagnosis definitive.
  12. Zambrano E, Reyes Mugica M, Franchi A, Rosai J. An osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: reports of 6 cases of a GIST simulator. Int J Surg Pathol. 2003;11:75-81 pubmed
    ..interpreted as examples of a distinctive type of gastrointestinal neoplasm which shares some features with clear cell sarcoma of soft parts (melanoma of soft parts), including in one case the chromosomal translocation that is ..
  13. Fujimoto M, Hiraga M, Kiyosawa T, Murakami T, Murata S, Ohtsuki M, et al. Complete remission of metastatic clear cell sarcoma with DAV chemotherapy. Clin Exp Dermatol. 2003;28:22-4 pubmed
    We report the first case of metastatic clear cell sarcoma with dramatic response to DAV treatment (DTIC + ACNU + VCR)...
  14. Kawai A, Hosono A, Nakayama R, Matsumine A, Matsumoto S, Ueda T, et al. Clear cell sarcoma of tendons and aponeuroses: a study of 75 patients. Cancer. 2007;109:109-16 pubmed
    b>Clear cell sarcoma (CCS) of tendons and aponeuroses (malignant melanoma of soft parts) is a rare melanocytic soft tissue sarcoma...
  15. Kosemehmetoglu K, Folpe A. Clear cell sarcoma of tendons and aponeuroses, and osteoclast-rich tumour of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: a review and update. J Clin Pathol. 2010;63:416-23 pubmed publisher
    b>Clear cell sarcoma (CCS) is a rare, distinctive soft tissue neoplasm, typically occurring in the distal extremities of young adult patients...
  16. Cangul I, van Garderen E, van der Poel H, Weijer K, Misdorp W. Tyrosinase gene expression in clear cell sarcoma indicates a melanocytic origin: insight from the first reported canine case. APMIS. 1999;107:982-8 pubmed
    ..soft tissue tumor in a dog, which clinically, grossly and histologically showed a close resemblance to human clear cell sarcoma, a soft tissue variant of malignant melanoma...
  17. Coindre J, Hostein I, Terrier P, Bouvier Labit C, Collin F, Michels J, et al. Diagnosis of clear cell sarcoma by real-time reverse transcriptase-polymerase chain reaction analysis of paraffin embedded tissues: clinicopathologic and molecular analysis of 44 patients from the French sarcoma group. Cancer. 2006;107:1055-64 pubmed
    b>Clear cell sarcoma (CCS) is a rare tumor with a very poor prognosis that occurs predominantly in the distal extremities of young adults. Most patients bear the t(12;22) reciprocal translocation, which involves the EWS and ATF1 genes...
  18. Song J, Choi J, Kim J, Jang S, Cho K. Diagnostic utility of EWS break-apart fluorescence in situ hybridization in distinguishing between non-cutaneous melanoma and clear cell sarcoma. Pathol Int. 2010;60:608-13 pubmed publisher
    b>Clear cell sarcoma (CCS) is a rare soft tissue sarcoma with morphological similarities to malignant melanoma (MM), but with a distinct genetic background that includes the chromosomal translocation t(12;22)(q13;q12)...
  19. Malchau S, Hayden J, Hornicek F, Mankin H. Clear cell sarcoma of soft tissues. J Surg Oncol. 2007;95:519-22 pubmed
    b>Clear cell sarcoma (CCS) is a rare but highly malignant tumor of soft tissues often appearing as a small tender mass in the deep tissues of the distal extremities...
  20. Liu S, Cheng H, Kwan W, Lubieniecka J, Nielsen T. Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models. Mol Cancer Ther. 2008;7:1751-61 pubmed publisher
    b>Clear cell sarcoma is an aggressive malignancy occurring most commonly in the distal extremities of young adults, characterized by t(12;22)(q13;q12) creating the chimeric fusion oncoprotein EWS-ATF1...
  21. Lauro S, Bordin F, Trasatti L, Lanzetta G, Della Rocca C, Frati L. Concurrent chemoimmunotherapy in metastatic clear cell sarcoma: a case report. Tumori. 1999;85:512-4 pubmed
    b>Clear cell sarcoma is a rare tumor with a poor prognosis. The therapeutic approach in the metastatic disease stage is controversial: to the authors' knowledge the use of concurrent chemoimmunotherapy has not been previously reported...
  22. Fujimura Y, Siddique H, Lee L, Rao V, Reddy E. EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function. Oncogene. 2001;20:6653-9 pubmed
    The recurrent t(12;22) (q13;q12) chromosomal translocation associated with soft tissue clear cell sarcoma results in a chimeric protein EWS-ATF-1 that acts as a constitutive transcriptional activator...
  23. Benchekroun A, Zannoud M, El Alj H, Nouini Y, Marzouk M, Faik M. [Clear cell sarcoma of the kidney: 3 case reports]. Prog Urol. 2002;12:469-73 pubmed
    ..Clear cell carcoma of the kidney is a distinct, highly malignant pediatric neoplasm. Its occurrence in adults is extremely rare and the subject of isolated case reports...
  24. Isoda H, Kuroda M, Saitoh M, Asakura T, Akai M, Ikeda K, et al. MR findings of clear cell sarcoma: two case reports. Clin Imaging. 2003;27:229-32 pubmed
    ..In the differential diagnosis of the mass developing in the tendons and aponeuroses, when these signs are absent, the probability of clear cell sarcoma is higher.
  25. Hourani M, Khoury N, Mourany B, Shabb N. MR appearance of clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts): radiologic-pathologic correlation. Skeletal Radiol. 2005;34:543-6 pubmed
    b>Clear cell sarcoma of tendons and aponeuroses (CCSTA) is a rare aggressive soft tissue tumor that frequently produces melanin. Its MR findings are rarely described in the literature...
  26. Antonescu C, Tschernyavsky S, Woodruff J, Jungbluth A, Brennan M, Ladanyi M. Molecular diagnosis of clear cell sarcoma: detection of EWS-ATF1 and MITF-M transcripts and histopathological and ultrastructural analysis of 12 cases. J Mol Diagn. 2002;4:44-52 pubmed
    b>Clear cell sarcoma (CCS), also known as melanoma of soft parts, is an uncommon deep soft tissue tumor presenting typically in the lower extremities of young adults...
  27. Creager A, Pitman M, Geisinger K. Cytologic features of clear cell sarcoma (malignant melanoma) of soft parts: a study of fine-needle aspirates and exfoliative specimens. Am J Clin Pathol. 2002;117:217-24 pubmed
    We describe the cytologic features of clear cell sarcoma of soft tissue (CCS) in 11 fine-needle aspiration biopsy (FNAB) specimens and 6 exfoliative specimens from 11 patients...
  28. Hisaoka M, Ishida T, Kuo T, Matsuyama A, Imamura T, Nishida K, et al. Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases. Am J Surg Pathol. 2008;32:452-60 pubmed publisher
    b>Clear cell sarcoma (CCS) of soft tissue is a rare sarcoma with morphologic similarities to malignant melanoma but a distinct genetic background including a chromosomal translocation, t(12;22)(q13;q12), or a resultant EWSR1-ATF1 fusion ..
  29. Albores Zúñiga O, Padilla Rosciano A, Martínez Said H, Cuéllar Hubbe M, Ramírez Bollas J. [Clear cell sarcoma and sentinel lymph node biopsy. Case report and literature review]. Cir Cir. 2006;74:121-5 pubmed
    The procedure of sentinel node biopsy has been used previously in clear cell sarcoma. There are few studies reported. Due to the similar biological features with melanoma, this procedure can be effective...
  30. Panagopoulos I, Mertens F, Isaksson M, Mandahl N. Absence of mutations of the BRAF gene in malignant melanoma of soft parts (clear cell sarcoma of tendons and aponeuroses). Cancer Genet Cytogenet. 2005;156:74-6 pubmed
    Malignant melanoma of soft parts (MMSP), also called clear cell sarcoma of tendons and aponeuroses, is cytogenetically characterized by the t(12;22)(q13;q12) resulting in the chimeric EWSR1/ATF1 gene...
  31. Hantschke M, Mentzel T, Rütten A, Palmedo G, Calonje E, Lazar A, et al. Cutaneous clear cell sarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of 12 cases emphasizing its distinction from dermal melanoma. Am J Surg Pathol. 2010;34:216-22 pubmed publisher
    b>Clear cell sarcoma (CCS) of tendons and aponeuroses/malignant melanoma (MM) of soft parts is a rare tumor and in the majority of cases presents a characteristic reciprocal translocation t(12;22)(q13;q12) that results in fusion of the EWS ..
  32. Davis I, McFadden A, Zhang Y, Coxon A, Burgess T, Wagner A, et al. Identification of the receptor tyrosine kinase c-Met and its ligand, hepatocyte growth factor, as therapeutic targets in clear cell sarcoma. Cancer Res. 2010;70:639-45 pubmed publisher
    b>Clear cell sarcoma (CCS), a childhood tumor of the tendons and aponeuroses, is uniformly fatal once it has metastasized because of its profound therapeutic resistance...
  33. Friedrichs N, Testi M, Moiraghi L, Modena P, Paggen E, Plötner A, et al. Clear cell sarcoma-like tumor with osteoclast-like giant cells in the small bowel: further evidence for a new tumor entity. Int J Surg Pathol. 2005;13:313-8 pubmed
    ..FISH strategies demostrating the presence of a t(12;22)(q13;q12) translocation, the diagnostic hallmark of clear cell sarcoma of soft parts...
  34. Garcia J, Kramer M, Mackey Z, O Donnell R, Horvai A. Utility of CD117 immunoreactivity in differentiating metastatic melanoma from clear cell sarcoma. Arch Pathol Lab Med. 2006;130:343-8 pubmed
    b>Clear cell sarcoma is a malignant soft tissue tumor with melanocytic differentiation. Molecular methods are sometimes necessary to identify the unique t(12; 22)(q13;q12) translocation and differentiate clear cell sarcoma from melanoma.
  35. Portugal R, Barroca H. Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumour. Cytopathology. 2008;19:80-5 pubmed
    ..study, we review the cytological and immunohistochemical characteristics of three children renal tumours, a Clear Cell Sarcoma of the Kidney (CCSK-case1), a Cellular Mesoblastic Nephroma (CMN-case2) and a Metanephric Adenoma (MA-case3) ..
  36. Suehara Y, Yazawa Y, Hitachi K, Terakado A. Clear cell sarcoma arising from the chest wall: a case report. J Orthop Sci. 2004;9:171-4 pubmed
    b>Clear cell sarcoma is a rare malignant soft tissue neoplasm that usually arises adjacent to tendons or aponeuroses. The clinical course is rather slow, with repeated local recurrences followed by late metastases and eventual death...
  37. Langezaal S, Graadt van Roggen J, Cleton Jansen A, Baelde J, Hogendoorn P. Malignant melanoma is genetically distinct from clear cell sarcoma of tendons and aponeurosis (malignant melanoma of soft parts). Br J Cancer. 2001;84:535-8 pubmed
    b>Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) and conventional malignant melanoma may demonstrate significant morphologic overlap at the light microscopic and ultrastructural level...
  38. Schaefer K, Brachwitz K, Wai D, Braun Y, Diallo R, Korsching E, et al. Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. Cancer Res. 2004;64:3395-405 pubmed
    b>Clear cell sarcoma of soft tissue (CCSST), also known as malignant melanoma of soft parts, represents a rare lesion of the musculoskeletal system usually affecting adolescents and young adults...
  39. Clark M, Johnson M, Thway K, Fisher C, Thomas J, Hayes A. Clear cell sarcoma (melanoma of soft parts): The Royal Marsden Hospital experience. Eur J Surg Oncol. 2008;34:800-4 pubmed
    b>Clear cell sarcoma (CCS) is a rare tumour with a propensity for local recurrence and nodal metastasis. About 300 cases have been reported, thus further clarification regarding the course and outcome of the disease is required.
  40. Dim D, Cooley L, Miranda R. Clear cell sarcoma of tendons and aponeuroses: a review. Arch Pathol Lab Med. 2007;131:152-6 pubmed
    b>Clear cell sarcoma of tendons and aponeuroses, also referred to as malignant melanoma of soft parts, is a rare malignancy derived from neural crest cells...
  41. Antonescu C, Nafa K, Segal N, Dal Cin P, Ladanyi M. EWS-CREB1: a recurrent variant fusion in clear cell sarcoma--association with gastrointestinal location and absence of melanocytic differentiation. Clin Cancer Res. 2006;12:5356-62 pubmed
    b>Clear cell sarcoma (CCS) usually arises in the lower extremities of young adults and is typically associated with a t(12;22) translocation resulting in the fusion of EWS (EWSR1) with ATF1, a gene encoding a member of the cyclic AMP-..
  42. Kural A, Onal B, Ozkara H, Cakarir C, Ayan I, Agaoglu F. Adult clear cell sarcoma of the kidney: a case report. BMC Urol. 2006;6:11 pubmed
    b>Clear cell sarcoma of the kidney (CCSK) in adults is extremely rare. Optimal treatment of adult patients with CCSK remains unclear.
  43. Radulescu V, Gerrard M, Moertel C, Grundy P, Mathias L, Feusner J, et al. Treatment of recurrent clear cell sarcoma of the kidney with brain metastasis. Pediatr Blood Cancer. 2008;50:246-9 pubmed
    b>Clear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain...
  44. Crnalic S, Panagopoulos I, Boquist L, Mandahl N, Stenling R, Löfvenberg R. Establishment and characterisation of a human clear cell sarcoma model in nude mice. Int J Cancer. 2002;101:505-11 pubmed
    We have established a new experimental model of human clear cell sarcoma, UM-CCS1, using serial subcutaneous transplantation of intact tumour tissue in nude mice...
  45. Curry C, Dishop M, Hicks M, Naeem R, Reed J, Lopez Terrada D. Clear cell sarcoma of soft tissue: diagnostic utility of fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction. J Cutan Pathol. 2008;35:411-7 pubmed publisher
    ..Melanocytic markers (HMB45, S-100) were diffusely positive. A diagnosis of clear cell sarcoma of soft tissue (CCSS) was made, and the mass was re-excised with negative margins. 28 months later, a 1...
  46. Katabuchi H, Honda R, Tajima T, Ohtake H, Kageshita T, Ono T, et al. Clear cell sarcoma arising in the retroperitoneum. Int J Gynecol Cancer. 2002;12:124-7 pubmed
    b>Clear cell sarcoma is a rare soft-tissue neoplasm, arising most commonly in the tendons and aponeuroses of young adults...
  47. Garcia J, Kramer M, O Donnell R, Horvai A. Mismatch repair protein expression and microsatellite instability: a comparison of clear cell sarcoma of soft parts and metastatic melanoma. Mod Pathol. 2006;19:950-7 pubmed
    b>Clear cell sarcoma of soft parts is a rare soft tissue malignancy that shows phenotypic overlap with cutaneous melanoma but can be distinguished by the presence of a t(12;22) translocation...
  48. Picciotto F, Zaccagna A, Derosa G, Pisacane A, Puiatti P, Colombo E, et al. Clear cell sarcoma (malignant melanoma of soft parts) and sentinel lymph node biopsy. Eur J Dermatol. 2005;15:46-8 pubmed
    b>Clear cell sarcoma of the tendons and aponeuroses is an aggressive, rare soft tissue tumour that occurs predominantly in the extremities of young adults...
  49. Pellin A, Monteagudo C, Lopez Gines C, Carda C, Boix J, Llombart Bosch A. New type of chimeric fusion product between the EWS and ATFI genes in clear cell sarcoma (malignant melanoma of soft parts). Genes Chromosomes Cancer. 1998;23:358-60 pubmed
    We report a new case of clear cell sarcoma (CCS) harboring the t(12;22)(q13;q12)...
  50. Panagopoulos I, Mertens F, Debiec Rychter M, Isaksson M, Limon J, Kardas I, et al. Molecular genetic characterization of the EWS/ATF1 fusion gene in clear cell sarcoma of tendons and aponeuroses. Int J Cancer. 2002;99:560-7 pubmed
    b>Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor particularly associated with tendons and aponeuroses...
  51. Rakheja D, Weinberg A, Tomlinson G, Partridge K, Schneider N. Translocation (10;17)(q22;p13): a recurring translocation in clear cell sarcoma of kidney. Cancer Genet Cytogenet. 2004;154:175-9 pubmed
    A clear cell sarcoma from the kidney of a 12-month-old male child manifested a balanced translocation, t(10;17)(q22;p13). This is the second report of this cytogenetic abnormality in renal clear cell sarcoma.
  52. Pauwels P, Debiec Rychter M, Sciot R, Vlasveld T, den Butter B, Hagemeijer A, et al. Clear cell sarcoma of the stomach. Histopathology. 2002;41:526-30 pubmed
    b>Clear cell sarcoma is a high-grade sarcoma with morphological features resembling malignant melanoma. This tumour is reported to display a characteristic distribution pattern nearly always involving the extremities...
  53. Davis I, Kim J, Ozsolak F, Widlund H, Rozenblatt Rosen O, Granter S, et al. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 2006;9:473-84 pubmed
    b>Clear cell sarcoma (CCS) harbors a pathognomonic chromosomal translocation fusing the Ewing's sarcoma gene (EWS) to the CREB family transcription factor ATF1 and exhibits melanocytic features...