mesenchymal chondrosarcoma

Summary

Summary: A rare aggressive variant of chondrosarcoma, characterized by a biphasic histologic pattern of small compact cells intermixed with islands of cartilaginous matrix. Mesenchymal chondrosarcomas have a predilection for flat bones; long tubular bones are rarely affected. They tend to occur in the younger age group and are highly metastatic. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1456)

Top Publications

  1. Brown R, Boyle J. Mesenchymal chondrosarcoma: molecular characterization by a proteomic approach, with morphogenic and therapeutic implications. Ann Clin Lab Sci. 2003;33:131-41 pubmed
    This study characterizes 3 cases of mesenchymal chondrosarcoma (MC) utilizing a proteomic approach that allows for the detection, visual quantification, cellular compartmentalization, and assessment of the functional state of certain ..
  2. Aziz S, Miremadi A, McCabe J. Mesenchymal chondrosarcoma of the maxilla with diffuse metastasis: case report and literature review. J Oral Maxillofac Surg. 2002;60:931-5 pubmed
  3. Font R, Ray R, Mazow M, Del Valle M. Mesenchymal chondrosarcoma of the orbit: a unique radiologic-pathologic correlation. Ophthalmic Plast Reconstr Surg. 2009;25:219-22 pubmed publisher
    To report a unique radiologic-histopathologic correlation of mesenchymal chondrosarcoma of the orbit in a 24-year-old Asian woman. Clinicopathologic case review...
  4. Matsuda Y, Sakayama K, Sugawara Y, Miyawaki J, Kidani T, Miyazaki T, et al. Mesenchymal chondrosarcoma treated with total en bloc spondylectomy for 2 consecutive lumbar vertebrae resulted in continuous disease-free survival for more than 5 years: case report. Spine (Phila Pa 1976). 2006;31:E231-6 pubmed
    ..A case report of an extremely rare malignant spinal tumor successfully treated with total en bloc spondylectomy and chemotherapy...
  5. Pellitteri P, Ferlito A, Fagan J, Suarez C, Devaney K, Rinaldo A. Mesenchymal chondrosarcoma of the head and neck. Oral Oncol. 2007;43:970-5 pubmed
    b>Mesenchymal chondrosarcoma of the head and neck is an uncommon tumor with a potential for exhibiting highly aggressive behavior...
  6. Kim G, Kim D, Park I, Ro J. Mesenchymal chondrosarcoma originating from the femoral vein. J Vasc Surg. 2003;37:202-5 pubmed
    b>Mesenchymal chondrosarcoma is a rare variant of chondrosarcomas characterized by a bimorphic pattern with areas of the undifferentiated malignant small cells and well differentiated cartilaginous islands...
  7. Gatter K, Olson S, Lawce H, Rader A. Trisomy 8 as the sole cytogenetic abnormality in a case of extraskeletal mesenchymal chondrosarcoma. Cancer Genet Cytogenet. 2005;159:151-4 pubmed
    b>Mesenchymal chondrosarcoma is a rare malignant tumor that comprises about 3-10% of all sarcomas. Reports of cytogenetic studies of mesenchymal chondrosarcoma are limited and no consistent cytogenetic abnormality has surfaced...
  8. Angiero F, Vinci R, Sidoni A, Stefani M. Mesenchymal chondrosarcoma of the left coronoid process: report of a unique case with clinical, histopathologic, and immunohistochemical findings, and a review of the literature. Quintessence Int. 2007;38:349-55 pubmed
    b>Mesenchymal chondrosarcoma (MCS) is a rare malignant neoplasm of bone or soft tissue origin, locally aggressive, rare in the oral cavity, of which fewer than 100 cases have been reported in the English literature...
  9. Cesari M, Bertoni F, Bacchini P, Mercuri M, Palmerini E, Ferrari S. Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution. Tumori. 2007;93:423-7 pubmed
    We analyzed clinical and treatment-related factors influencing the outcome of patients with mesenchymal chondrosarcoma (MC)...

More Information

Publications87

  1. Abbas M, Ajrawi T, Tungekar M. Mesenchymal chondrosarcoma of the thyroid -- a rare tumour at an unusual site. APMIS. 2004;112:384-9 pubmed
    ..immunohistochemical and ultrastructural features of the first case in the literature of a primary mesenchymal chondrosarcoma (MC) of the thyroid and discuss its differential diagnosis at unusual extraskeletal sites...
  2. Ly J. Mesenchymal chondrosarcoma of the maxilla. AJR Am J Roentgenol. 2002;179:1077-8 pubmed
  3. Gorelik B, Ziv I, Shohat R, Wick M, Hankins W, Sidransky D, et al. Efficacy of weekly docetaxel and bevacizumab in mesenchymal chondrosarcoma: a new theranostic method combining xenografted biopsies with a mathematical model. Cancer Res. 2008;68:9033-40 pubmed publisher
    The paucity of clinical treatment data on rare tumors, such as mesenchymal chondrosarcoma (MCS), emphasizes the need in theranostic tools for these diseases...
  4. Kaur A, Kishore P, Agrawal A, Gupta A. Mesenchymal chondrosarcoma of the orbit: a report of two cases and review of the literature. Orbit. 2008;27:63-7 pubmed publisher
    b>Mesenchymal chondrosarcoma, an uncommon lesion in bone and extraskeletal tissue, is extremely rare in the orbit...
  5. Odashiro A, Leite L, Oliveira R, Tamashiro C, Pereira P, Miiji L, et al. Primary orbital mesenchymal chondrosarcoma: a case report and literature review. Int Ophthalmol. 2009;29:173-7 pubmed publisher
    b>Mesenchymal chondrosarcoma (MC) is a subtype of chondrosarcoma, with an incidence varying from 1 to 8% of all chondrosarcomas. It is an aggressive neoplasm with a high tendency for late recurrence and occasional delayed distant metastasis...
  6. White D, Ly J, Beall D, McMillan M, McDermott J. Extraskeletal mesenchymal chondrosarcoma: case report. Clin Imaging. 2003;27:187-90 pubmed
    This is a case report of an extraskeletal mesenchymal chondrosarcoma (ESMC) that originally occurred in the retroperitoneum of a 24-year-old female and later metastasized to the left proximal humerus...
  7. Naumann S, Krallman P, Unni K, Fidler M, Neff J, Bridge J. Translocation der(13;21)(q10;q10) in skeletal and extraskeletal mesenchymal chondrosarcoma. Mod Pathol. 2002;15:572-6 pubmed
    Cytogenetic studies of mesenchymal chondrosarcoma are few and to date, no specific or recurrent aberrations have been found...
  8. Fanburg Smith J, Auerbach A, Marwaha J, Wang Z, Rushing E. Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. Hum Pathol. 2010;41:653-62 pubmed publisher
    b>Mesenchymal chondrosarcoma, a rare malignant round cell and hyaline cartilage tumor, is most commonly intraosseous but can occur in extraskeletal sites...
  9. Park Y, Park H, Chi S, Kim C, Sohn K, Koh J, et al. Overexpression of p53 and rare genetic mutation in mesenchymal chondrosarcoma. Oncol Rep. 2000;7:1041-7 pubmed
    b>Mesenchymal chondrosarcoma is extremely rare and accounts for less than 2% of all chondrosarcomas...
  10. Anderson J, Lucas G. Extraskeletal mesenchymal chondrosarcoma of the forearm: a case report. J Hand Surg Am. 2007;32:389-92 pubmed
    ..Of the extraskeletal locations, the meninges, brain, and thigh are the most common. Involvement of the forearm is a rare occurrence. This case report describes an extraskeletal mesenchymal chondrosarcoma involving the forearm.
  11. Dantonello T, Int Veen C, Leuschner I, Schuck A, Furtwaengler R, Claviez A, et al. Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups. Cancer. 2008;112:2424-31 pubmed publisher
    b>Mesenchymal chondrosarcoma (MCS) is a rare tumor with a strong tendency toward late recurrences leading to reported 10-year survival rates below 50%...
  12. Wehrli B, Huang W, de Crombrugghe B, Ayala A, Czerniak B. Sox9, a master regulator of chondrogenesis, distinguishes mesenchymal chondrosarcoma from other small blue round cell tumors. Hum Pathol. 2003;34:263-9 pubmed
    ..For this reason, we examined the utility of Sox9 in distinguishing mesenchymal chondrosarcoma (a small cell malignancy thought to be derived from primitive chondroprogenitor cells) from other ..
  13. Oh B, Han Y, Lee B, Kim S, Hwang Y, Seo J, et al. Primary extraskeletal mesenchymal chondrosarcoma arising from the pancreas. Korean J Radiol. 2007;8:541-4 pubmed
    We report here on a case of primary extraskeletal mesenchymal chondrosarcoma that arose from the pancreas. A 41-year-old man was evaluated by CT to find the cause of his abdominal pain...
  14. Brown R. Morphoproteomic portrait of the mTOR pathway in mesenchymal chondrosarcoma. Ann Clin Lab Sci. 2004;34:397-9 pubmed
    ..This communication illustrates the application of such an approach in depicting the mTOR pathway in mesenchymal chondrosarcoma.
  15. Knott P, Gannon F, Thompson L. Mesenchymal chondrosarcoma of the sinonasal tract: a clinicopathological study of 13 cases with a review of the literature. Laryngoscope. 2003;113:783-90 pubmed
    b>Mesenchymal chondrosarcoma of the sinonasal tract is a rare, malignant tumor of extraskeletal origin...
  16. Kaneko T, Suzuki Y, Takata R, Takata K, Sakuma T, Fujioka T. Extraskeletal mesenchymal chondrosarcoma of the kidney. Int J Urol. 2006;13:285-6 pubmed
    ..The pathological diagnosis was extraskeletal mesenchymal chondrosarcoma of the kidney. No recurrence or metastasis occurred during a 6-year follow up...
  17. Jamal W, Rhys Evans P, Sheppard M. Mesenchymal chondrosarcoma of the vagus nerve. J Laryngol Otol. 2002;116:644-6 pubmed
    b>Mesenchymal chondrosarcoma is a rare, aggressive, malignant neoplasm, which arises from extraskeletal sites in 30-40 per cent of cases. It is extremely rare in children...
  18. Handa U, Singhal N, Punia R, Garg S, Mohan H. Cytologic features and differential diagnosis in a case of extraskeletal mesenchymal chondrosarcoma: a case report. Acta Cytol. 2009;53:704-6 pubmed
    ..Extraskeletal myxoid chondrosarcoma (EMC) is an uncommon tumor. On fine needle aspiration (FNA) it has to be distinguished from other benign and malignant soft tissue lesions...
  19. Bu X, Dai X. Primary mesenchymal chondrosarcoma of the pancreas. Ann R Coll Surg Engl. 2010;92:W10-2 pubmed publisher
    ..The mass was completely excised, and the histopathological diagnosis was primary mesenchymal pancreatic chondrosarcoma. Tumour recurred at follow-up 52 months postoperatively...
  20. Sadashiva N, Sharma A, Shukla D, Rajalakshmi P, Mahadevan A, Devi B. Intracranial Extraskeletal Mesenchymal Chondrosarcoma. World Neurosurg. 2016;95:618.e1-618.e6 pubmed publisher
    ..The potential effect of postoperative radiotherapy and chemotherapy is controversial. This article sheds some light on variable prognosis of this tumor. ..
  21. Yassa M, Bahary J, Bourguoin P, Belair M, Berthelet F, Bouthillier A. Intra-parenchymal mesenchymal chondrosarcoma of the cerebellum: case report and review of the literature. J Neurooncol. 2005;74:329-31 pubmed
    ..On pathology, the lesion was found to be compatible with a mesenchymal chondrosarcoma. The patient received adjuvant radiation treatment and remains free of disease 60 months after ..
  22. Al Mendalawi M. Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. Saudi Med J. 2018;39:107 pubmed publisher
    ..No Abstract Available]. ..
  23. Dubova E, Mishnev O, Perepechin V, Shchegolev A. [Mesenchymal chondrosarcoma of the lung]. Arkh Patol. 2008;70:44-5 pubmed
    The authors present the data available in the literature and their observation of mesenchymal chondrosarcoma of the lung a 68-year-old female patient...
  24. Bousdras V, Flanagan A, Bousdras K, Vourvachis M, Newman L, Kalavrezos N. Multiple-site osteosarcomas of the jaw in a single patient. A true case of a metachronous lesion?. Int J Oral Maxillofac Surg. 2010;39:733-6 pubmed publisher
    ..The pathogenesis of this disease is unknown as it is unclear whether the lesions represent independent primary tumours or metastatic disease. ..
  25. Okamoto Y, Minami M, Ueda T, Inadome Y, Tatsumura M, Sakane M. Extraskeletal mesenchymal chondrosarcoma of the cervical meninx. Radiat Med. 2007;25:355-8 pubmed
    We report a case of recurrent mesenchymal chondrosarcoma in the cervical paravertebral region that was diagnosed preoperatively by imaging studies...
  26. Guo J, Gu Y, Guo L, Tong Z, Wu X, Zhang J, et al. A Case of Mesenchymal Chondrosarcoma Arising from the Femoral Vein with 8 Years of Follow-up. Ann Vasc Surg. 2015;29:1455.e1-5 pubmed publisher
    b>Mesenchymal chondrosarcoma (MCS) is an infrequent malignancy of bone and soft tissue that is characterized by a peculiar bimorphic histologic pattern with areas of undifferentiated malignant small cells surrounding well-differentiated ..
  27. Zhang H, Wang S, Cheng Z, Liu H. Primary extraskeletal mesenchymal chondrosarcoma arising from the iliac vein. Saudi Med J. 2017;38:1058-1061 pubmed publisher
    The iliac vein is an extremely rare site for mesenchymal chondrosarcoma, and patients with primary extraskeletal mesenchymal chondrosarcoma arising from a vein always suffer a very poor prognosis...
  28. Theodorou D, Theodorou S, Xenakis T, Demou S, Agnantis N, Soucacos P. Mesenchymal chondrosarcoma of soft tissues of the calf. Am J Orthop (Belle Mead NJ). 2001;30:329-32 pubmed
    ..We describe a mesenchymal chondrosarcoma of the soft tissues of the calf and review the differential diagnosis of this poorly understood entity.
  29. Geng J, Ding Y, Liu L, Zhu M, Han H, Cai J. [Primary mesenchymal chondrosarcoma of the lung]. Zhonghua Bing Li Xue Za Zhi. 2005;34:317-8 pubmed
  30. Zhao F, Fan S, Qin A, Jin G. Mesenchymal chondrosarcoma of the talus: a case report. Foot Ankle Int. 2007;28:1095-9 pubmed
  31. Biagini R, Orsini U, Demitri S, Ruggieri P, Ferrari S, Bertoni F. Mesenchymal chondrosarcoma of the sacrum: a case report and review of the literature. Tumori. 2000;86:75-8 pubmed
    The authors present a case of mesenchymal chondrosarcoma located in the sacrum of a 23-year-old patient treated with radiotherapy and chemotherapy. A review of the literature on the topic is also reported.
  32. Hannachi Sassi S, Mekni A, Sassi B, Mrad K, Ben Romdhane K. [Extraskeletal mesenchymal chondrosarcoma: a case report and review of the literature]. Rev Chir Orthop Reparatrice Appar Mot. 2004;90:265-8 pubmed
    We report a new case of mesenchymal chondrosarcoma in a 25-Year-old woman who presented a tumefaction of the anteromedial aspect of the mid left leg which had developed over two Years...
  33. Park Y, Park H, Kim Y, Chi S, Unni K. Lack of Bcl10 mutations in malignant cartilaginous tumors. Int J Mol Med. 2002;9:217-9 pubmed
    ..Our results strongly suggest that somatic mutations of Bcl10 are extremely rare in malignant cartilaginous tumors and do not commonly contribute to their molecular pathogenesis. ..
  34. Yilmaz M, Kara M, Aksoy M, Guler G, Ersoy U. Brachial plexus neuroma mimicking local recurrence of malignant mesenchymal tumor after forequarter amputation. Orthopedics. 2008;31:173 pubmed
    ..Therefore, when recurrent chest wall tumor is suspected in such cases, stump neuroma resulting from transection of the brachial plexus should be included in the differential diagnosis. ..
  35. Salvati M, Caroli E, Frati A, Piccirilli M, Agrillo A, Brogna C, et al. Central nervous system mesenchymal chondrosarcoma. J Exp Clin Cancer Res. 2005;24:317-24 pubmed
    ..We describe two rare examples of intracranial mesenchymal chondrosarcoma with a review of the literature, in an attempt to clarify the clinical characteristics, prognosis and ..
  36. Chen S, Wang Y, Su G, Chen B, Lin D. Primary intraspinal dumbbell-shaped mesenchymal chondrosarcoma with massive calcifications: a case report and review of the literature. World J Surg Oncol. 2016;14:203 pubmed publisher
    b>Mesenchymal chondrosarcoma is a rare malignant tumor arising from bone or soft tissues. Instraspinal dumbbell-shaped mesenchymal chondrosarcoma is even rarer; however, it should not be neglected by clinicians...
  37. Schörle C, Unni K, Aigner T. [Neoplastic chondroneogenesis as a characteristic of mesenchymal chondrosarcomas]. Orthopade. 2002;31:544-50 pubmed
    ..The results characterize mesenchymal chondrosarcomas as skeletal malignancies that arise from undifferentiated chondroprogenitor cells and have the potential to undergo all steps of chondrocytic differentiation. ..
  38. Munday J, Prahl A. Retroperitoneal extraskeletal mesenchymal chondrosarcoma in a dog. J Vet Diagn Invest. 2002;14:498-500 pubmed
    ..This is the first description of this type of tumor developing distant metastases. Evidence from this case and previous reports suggests that EMCs are associated with a poor prognosis. ..
  39. Koelsche C, Hartmann W, Schrimpf D, Stichel D, Jabar S, Ranft A, et al. Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information. Mod Pathol. 2018;31:1246-1256 pubmed publisher
    ..However, they also may include other tumors such as mesenchymal chondrosarcoma, synovial sarcoma, or small cell osteosarcoma...
  40. Devaney K, Vinh T, Sweet D. Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. Hum Pathol. 1993;24:1211-25 pubmed
    ..considerations, including Ewing's sarcoma, atypical Ewing's sarcoma, primitive neuroectodermal tumor, mesenchymal chondrosarcoma, lymphoma, and the Askin tumor...
  41. Saito Y, Takemura S, Sakurada K, Sato S, Kayama T. [Intracranial extraskeletal mesenchymal chondrosarcoma arising from falx: a case report and literature review]. No Shinkei Geka. 2010;38:441-8 pubmed
    Intracranial extraskeletal mesenchymal chondrosarcoma is a very rare tumor that affects young adults. We report a 31-year-old woman with a huge intracranial extraskeletal mesenchymal chondrosarcoma...
  42. Hoshimaru M, Takahashi T, Tokuhashi Y, Nozaki K, Hashimoto N. ["How I do it" no. 4, a case of mesenchymal chondrosarcoma in the upper thoracic spine]. No Shinkei Geka. 2003;31:821-2; discussion 823-34 pubmed
  43. Aigner T, Loos S, Muller S, Sandell L, Unni K, Kirchner T. Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas. Am J Pathol. 2000;156:1327-35 pubmed
    ..In this study, the use of in situ detection techniques on a large series of mesenchymal chondrosarcoma specimens allowed the identification of tumor-cell differentiation pathways in these neoplasms...
  44. Marshman L, Gunasekera L, Rose P, Olney J. Primary intracerebral mesenchymal chondrosarcoma with rhabdomyosarcomatous differentiation: case report and literature review. Br J Neurosurg. 2001;15:419-24 pubmed
    ..Intracranial mesenchymal chondrosarcoma (MsCh-S) is a rarer, more malignant variant associated with the supratentorial meninges...
  45. Misra V, Singh P. Cytodiagnosis of extraosseous mesenchymal chondrosarcoma of meninges: a case report. Acta Cytol. 2008;52:366-8 pubmed
    Extraosseous mesenchymal chondrosarcoma (MC) is a rare neoplasm. Most reports in the literature are based on histologic diagnosis. Cases diagnosed on the basis of cytologic features are few.
  46. Romanucci M, Bongiovanni L, Petrizzi L, della Salda L. Cutaneous extraskeletal mesenchymal chondrosarcoma in a cat. Vet Dermatol. 2005;16:121-4 pubmed
    ..A diagnosis of extraskeletal mesenchymal chondrosarcoma was made based on the histological pattern - characterized by the coexistence of cartilaginous islands ..
  47. Taori K, Patil P, Attarde V, Chandanshive S, Rangankar V, Rewatkar N. Primary retroperitoneal extraskeletal mesenchymal chondrosarcoma: a computed tomography diagnosis. Br J Radiol. 2007;80:e268-70 pubmed
    ..Here we present a rare case of retroperitoneal extraskeletal mesenchymal chondrosarcoma (ESMC) in a 50-year-old female that showed characteristic extensive calcification...
  48. Koriyama N, Nishimoto K, Kodama T, Nakazaki M, Kurono Y, Yoshida H, et al. Oncogenic osteomalacia in a case with a maxillary sinus mesenchymal tumor. Am J Med Sci. 2006;332:142-7 pubmed
    ..quot; The expression of FGF23 was demonstrated in the tumor by the immunohistochemical techniques and a Western analysis...
  49. Stenstam B, Pellettieri L, Sorteberg W, Rezaei A, Sköld K. BNCT for recurrent intracranial meningeal tumours - case reports. Acta Neurol Scand. 2007;115:243-7 pubmed
    ..The investigation was designed to explore the efficacy of boron neutron capture therapy (BNCT) as treatment for recurrent intracranial meningeal tumours...
  50. Huang H, Hsieh M, Chen W, Ko S, Yang B, Huang S. Primary mesenchymal chondrosarcoma of the lung. Ann Thorac Surg. 2002;73:1960-2 pubmed
    b>Mesenchymal chondrosarcoma has been well documented in the somatic soft tissue and bone...
  51. Baines S, Lewis S, White R. Primary thoracic wall tumours of mesenchymal origin in dogs: a retrospective study of 46 cases. Vet Rec. 2002;150:335-9 pubmed
    ..Early, radical surgical excision is recommended in the management of tumours of the chest wall. The prognosis depends on the histologic type of tumour and a histological diagnosis is mandatory before excision...
  52. Bruns J, Elbracht M, Niggemeyer O. Chondrosarcoma of bone: an oncological and functional follow-up study. Ann Oncol. 2001;12:859-64 pubmed
    ..Regarding age, grade, and line of resection no tendency of any dependence was detected, but worst results were seen in those with a stage III tumor and dedifferentiated CS...
  53. Ben Brahim E, Zermani R, El Mezni F, Farah F, Ismail O, Adouani A, et al. [Mesenchymatous chondrosarcoma of the superior maxillary bone. A case report]. Tunis Med. 2001;79:54-7 pubmed
    The authors report a new case of mesenchymal chondrosarcoma (MCS), occurring in the upper jaw bone of a 19 year-old woman. Radiographic picture in the bone shows an aggressive osteolytic tumor suspect of malignancy...
  54. Hameetman L, Kok P, Eilers P, Cleton Jansen A, Hogendoorn P, Bovee J. The use of Bcl-2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting. Virchows Arch. 2005;446:430-7 pubmed
  55. Al Bayaty H, Murti P, Thomson E, Deen M. Painful, rapidly growing mass of the mandible. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:7-11 pubmed
  56. Kawashima M, Suzuki S, Yamashima T, Fukui M, Iwaki T. Prostaglandin D synthase (beta-trace) in meningeal hemangiopericytoma. Mod Pathol. 2001;14:197-201 pubmed
    ..For comparison, 15 meningiomas, 14 soft-tissue HPCs, 1 mesenchymal chondrosarcoma, 3 choroid plexus papillomas, and 7 oligodendrogliomas were also examined...
  57. Mawad J, Mackay B, Raymond A, Ayala A. Electron microscopy in the diagnosis of small round cell tumors of bone. Ultrastruct Pathol. 1994;18:263-8 pubmed
  58. Mody M, Rao G, Rhines L. Surgical management of spinal mesenchymal tumors. Curr Oncol Rep. 2006;8:297-304 pubmed
    ..Postoperative adjuvant chemotherapy with or without radiation may help to delay recurrence and improve outcomes. We present three cases of our surgical experience with spinal mesenchymal tumors for illustrative purposes...
  59. Reyaz N, Ashraf M. Intracranial extra-skeletal mesenchymal chondrosarcoma. J Ayub Med Coll Abbottabad. 2006;18:86-7 pubmed
    Intracranial Mesenchymal Chondrosarcoma is a very rare and uncommon entity that affects young adults. We came across one such patient who presented with severe headache and intermittent nausea and vomiting...
  60. Chen J, Hsu S, Ho J. Extraskeletal intracranial mesenchymal chondrosarcoma: case report and literature review. Kaohsiung J Med Sci. 2004;20:240-6 pubmed
    We present the case of a 13-year-old girl with a huge intracranial mesenchymal chondrosarcoma. She had suffered from severe headache, diplopia, intermittent nausea and vomiting for 1 month...
  61. Hannan F, Athanasou N, Teh J, Gibbons C, Shine B, Thakker R. Oncogenic hypophosphataemic osteomalacia: biomarker roles of fibroblast growth factor 23, 1,25-dihydroxyvitamin D3 and lymphatic vessel endothelial hyaluronan receptor 1. Eur J Endocrinol. 2008;158:265-71 pubmed publisher
    ..Serum FGF23 and 1,25(OH)2D3 were found to be reliable biomarkers for OOM. In addition, the demonstration of lymphatics in the PMTMCT helps to distinguish this tumour from most typical benign haemangiomas...
  62. Gelderblom H, Hogendoorn P, Dijkstra S, van Rijswijk C, Krol A, Taminiau A, et al. The clinical approach towards chondrosarcoma. Oncologist. 2008;13:320-9 pubmed publisher
    ..Chemotherapy is only possibly effective in mesenchymal chondrosarcoma, and is of uncertain value in dedifferentiated chondrosarcoma...
  63. Suryanarayana K, Balakrishnan R, Rao L, Rahim T. Parapharyngeal space mesenchymal chondrosarcoma in childhood. Int J Pediatr Otorhinolaryngol. 1999;50:69-72 pubmed
    A case of extra osseous mesenchymal chondrosarcoma occuring in the parapharyngeal space in a 7-year-old girl, is being presented for its rarity...
  64. Antonio S, Branstetter IV B, Hirsch B. Mesenchymal chondrosarcoma presenting as an external auditory canal mass. Otol Neurotol. 2003;24:344-5 pubmed
  65. Angotti Neto H, Cunha L, Oliveira A, Monteiro M. Mesenchymal chondrosarcoma of the orbit. Ophthalmic Plast Reconstr Surg. 2006;22:378-82 pubmed
    To describe a patient with mesenchymal chondrosarcoma of the orbit, review clinical and imaging findings, and refine the differential diagnosis from other tumors of the orbit.
  66. Yamamoto H, Watanabe K, Nagata M, Honda I, Watanabe S, Soda H, et al. Surgical treatment for pancreatic metastasis from soft-tissue sarcoma: report of two cases. Am J Clin Oncol. 2001;24:198-200 pubmed
    ..The first case was a 29-year-old man who had a history of removal of mesenchymal chondrosarcoma in the left thigh in 1986 and who underwent distal pancreatectomy and the enucleation of a tumor in the ..
  67. Inenaga C, Morii K, Tamura T, Tanaka R, Takahashi H. Mesenchymal chondrosarcoma of the sellar region. Acta Neurochir (Wien). 2003;145:593-7; discussion 597 pubmed
    It is known that, although rare, mesenchymal chondrosarcoma can originate intracranially. However, no such malignant tumour has been described in the sellar region.
  68. Trembath D, Dash R, Major N, Dodd L. Cytopathology of mesenchymal chondrosarcomas: a report and comparison of four patients. Cancer. 2003;99:211-6 pubmed
    b>Mesenchymal chondrosarcoma (MC) is an infrequent neoplasm, representing approximately 1% of all chondrosarcomas. Cytologic descriptions of MCs have been confined to rare case reports...
  69. Parmar C, Jojo A, Vachhani K, Vijayan S. Primary chondrosarcoma of the heart. Eur J Cardiothorac Surg. 2008;33:513-5 pubmed publisher
    ..The histopathology of the excised mass revealed mesenchymal chondrosarcoma, confirmed by immunohistochemistry. Clinical and radiological studies did not reveal any other neoplasm.
  70. Yildiz F, Gurel A, Yesildere T, Ozer K. Frontal chondrosarcoma in a cat. J Vet Sci. 2003;4:193-4 pubmed
    ..The post-surgical outcome of the patient was observed, and recurrence on the same site was reported within 2 months...
  71. Hamada H, Taskin Yücel O, Engin H, Sungur A. Mesenchymal chondrosarcoma of the nasopharynx. Otolaryngol Head Neck Surg. 2005;133:639 pubmed
  72. Kotil K, Bilge T, Olagac V. Primary intradural myxoid chondrosarcoma: a case report and review in the literature. J Neurooncol. 2005;75:169-72 pubmed
    ..The exact origin of rare intradural spinal chondrosarcomas remains obscure. We report the first case in the literature of a primary intradural myxoid chondrosarcoma...
  73. Johnson J, Broccoli D. Telomere maintenance in sarcomas. Curr Opin Oncol. 2007;19:377-82 pubmed
    ..To examine the activation of telomere maintenance in a variety of sarcoma subtypes, and to review the consequences of telomere maintenance with respect to genome stability and tumor progression...
  74. Chen S, Wang H, Jaing T, Hsueh C, Lo W, Tseng C. Primary intraspinal mesenchymal chondrosarcoma: report of one case. Acta Paediatr Taiwan. 2005;46:308-10 pubmed
    We report a case of primary intraspinal mesenchymal chondrosarcoma in an 11-year-old boy. Contrast-enhanced MRI revealed a hyperintense, sausage-shaped mass extending from C7 to T2...
  75. Huang K, Tzaan W, Lin C. Primary intraspinal mesenchymal chondrosarcoma: a case report and literature review. Chang Gung Med J. 2003;26:370-6 pubmed
    ..Microscopic examination and immunohistochemical studies confirmed the diagnosis of mesenchymal chondrosarcoma. Spinal irradiation and chemotherapy were also administered for prevention of local recurrence and ..
  76. Haeusler G, Freilinger M, Dominkus M, Egerbacher M, Amann G, Kolb A, et al. Tumor-induced hypophosphatemic rickets in an adolescent boy--clinical presentation, diagnosis, and histological findings in growth plate and muscle tissue. J Clin Endocrinol Metab. 2010;95:4511-7 pubmed publisher
    ..The mechanism behind disabling muscle weakness in tumor-induced hypophosphatemic rickets is obscure. Histological investigation of growth plate tissue of patients with tumor-induced osteomalacia has so far not been reported...
  77. Li Y, Yao X. Primary intradural mesenchymal chondrosarcoma of the spine in a child. Pediatr Radiol. 2007;37:1155-8 pubmed
    We report a primary intradural mesenchymal chondrosarcoma of the spine in a 3-year-old girl. MRI revealed a markedly enhancing oval mass associated with focal areas of low signal intensity extending from T11 to L1...
  78. Ehara S, Rosenberg A, Kattapuram S. Atypical lipomas, liposarcomas, and other fat-containing sarcomas. CT analysis of fat element. Clin Imaging. 1995;19:50-3 pubmed
    ..The radiographic appearance of fat in and around soft tissue sarcomas was evaluated to assess the diagnostic potential of this finding. Based on the distribution of fat and other components, these tumors are classified into three types...