chondrosarcoma

Summary

Summary: A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)

Top Publications

  1. Lu X, Tang X, Guo W, Ren T, Zhao H. Sorafenib induces growth inhibition and apoptosis of human chondrosarcoma cells by blocking the RAF/ERK/MEK pathway. J Surg Oncol. 2010;102:821-6 pubmed publisher
    b>Chondrosarcoma represents the second most common primary malignant bone tumor causing significant morbidity due to local recurrence and limited treatment options...
  2. van Oosterwijk J, Herpers B, Meijer D, Briaire de Bruijn I, Cleton Jansen A, Gelderblom H, et al. Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance. Ann Oncol. 2012;23:1617-26 pubmed publisher
    ..We studied the sensitivity of chondrosarcoma cell lines (SW1353, CH2879, JJ012, OUMS27) and two primary cultures for doxorubicin and cisplatin...
  3. Kerr D, Lopez H, Deshpande V, Hornicek F, Duan Z, Zhang Y, et al. Molecular distinction of chondrosarcoma from chondroblastic osteosarcoma through IDH1/2 mutations. Am J Surg Pathol. 2013;37:787-95 pubmed publisher
    Distinguishing chondrosarcoma from chondroblastic osteosarcoma can be difficult and highly subjective, especially on a small biopsy specimen...
  4. Liang W, Li X, Li Y, Li C, Gao B, Gan H, et al. Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells. Int J Oncol. 2014;44:91-8 pubmed publisher
    ..However, its effects on chondrosarcoma cell apoptosis are still undefined...
  5. Hou C, Chiang Y, Fong Y, Tang C. WISP-1 increases MMP-2 expression and cell motility in human chondrosarcoma cells. Biochem Pharmacol. 2011;81:1286-95 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs...
  6. Pollack S, Li Y, Blaisdell M, Farrar E, Chou J, Hoch B, et al. NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine. PLoS ONE. 2012;7:e32165 pubmed publisher
    b>Chondrosarcoma has no proven systemic option in the metastatic setting. The development of a non-cross-resistant strategy, such as cellular immunotherapy using antigen-specific T cells would be highly desirable...
  7. Meijer D, de Jong D, Pansuriya T, van den Akker B, Picci P, Szuhai K, et al. Genetic characterization of mesenchymal, clear cell, and dedifferentiated chondrosarcoma. Genes Chromosomes Cancer. 2012;51:899-909 pubmed publisher
    Clear cell, mesenchymal, and dedifferentiated chondrosarcoma are rare, cartilaginous tumors with limited treatment options other than surgery...
  8. Li Y, Yu C, Wu S, Dai M, Lee H. Malignant mesenchymal tumor with leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, and osteosarcoma differentiation: case report and literature review. Diagn Pathol. 2011;6:35 pubmed publisher
    A case of malignant mesenchymoma of the bladder containing leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma, and myxomatous components is described...
  9. Cai L, Ye H, Li X, Lin Y, Yu F, Chen J, et al. Chemical constituents of volatile oil from Pyrolae herba and antiproliferative activity against SW1353 human chondrosarcoma cells. Int J Oncol. 2013;42:1452-8 pubmed publisher
    ..oil from Pyrolae herba (PHVO) and evaluate the antiproliferative activity of PHVO against SW1353 human chondrosarcoma cells...

More Information

Publications76

  1. Tang C, Keng Y, Liu J. HMGB-1 induces cell motility and ?5?1 integrin expression in human chondrosarcoma cells. Cancer Lett. 2012;322:98-106 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis...
  2. Sun W, Li J, Li Q, Li G, Cai Z. Clinical effectiveness of hemipelvic reconstruction using computer-aided custom-made prostheses after resection of malignant pelvic tumors. J Arthroplasty. 2011;26:1508-13 pubmed publisher
    ..In conclusion, computer-aided custom-made hemipelvic prosthesis can be applied to quickly and effectively restore the bone defect after internal hemipelvectomy for treatment of pelvic tumors. ..
  3. Söderström M, Palokangas T, Vahlberg T, Bohling T, Aro H, Carpen O. Expression of ezrin, Bcl-2, and Ki-67 in chondrosarcomas. APMIS. 2010;118:769-76 pubmed publisher
    ..a membrane-cytoskeleton linker and regulator of cellular signaling, is associated with clinical features of chondrosarcoma. For this purpose, we studied the expression of ezrin in 54 chondrosarcomas by immunohistochemistry and ..
  4. Boeuf S, Bovee J, Lehner B, van den Akker B, van Ruler M, Cleton Jansen A, et al. BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors. BMC Cancer. 2012;12:488 pubmed publisher
    ..growth factor ? (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma. In order to uncover their possible implication, the aim of this study was to perform a systematic ..
  5. Lechler P, Renkawitz T, Campean V, Balakrishnan S, Tingart M, Grifka J, et al. The antiapoptotic gene survivin is highly expressed in human chondrosarcoma and promotes drug resistance in chondrosarcoma cells in vitro. BMC Cancer. 2011;11:120 pubmed publisher
    b>Chondrosarcoma is virtually resistant to chemotherapy and radiation therapy...
  6. Li X, Ye H, Cai L, Yu F, Chen W, Lin R, et al. Millimeter wave radiation induces apoptosis via affecting the ratio of Bax/Bcl-2 in SW1353 human chondrosarcoma cells. Oncol Rep. 2012;27:664-72 pubmed publisher
    ..These data suggested that millimeter wave radiation may induce apoptosis via affecting the ratio of Bax/Bcl-2 in SW1353 cells...
  7. Soldatos T, McCarthy E, Attar S, Carrino J, Fayad L. Imaging features of chondrosarcoma. J Comput Assist Tomogr. 2011;35:504-11 pubmed publisher
  8. Tsou H, Chen H, Hung Y, Chang C, Li T, Fong Y, et al. HGF and c-Met interaction promotes migration in human chondrosarcoma cells. PLoS ONE. 2013;8:e53974 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumor with a potent capacity for local invasion and causing distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs...
  9. Verdegaal S, Brouwers H, van Zwet E, Hogendoorn P, Taminiau A. Low-grade chondrosarcoma of long bones treated with intralesional curettage followed by application of phenol, ethanol, and bone-grafting. J Bone Joint Surg Am. 2012;94:1201-7 pubmed publisher
    ..Because of the wide variety of different diagnoses and treatments, there is still a lack of knowledge about the effectiveness of the use of phenol as local adjuvant therapy in patients with grade-I central chondrosarcoma of a long bone.
  10. Chen C, Zhou H, Liu X, Liu Z, Ma Q. Reduced expression of von Hippel-Lindau protein correlates with decreased apoptosis and high chondrosarcoma grade. J Bone Joint Surg Am. 2011;93:1833-40 pubmed publisher
    ..well as several other types of human tumors, but the potential role of the VHL protein (pVHL) in patients with chondrosarcoma has not been characterized...
  11. Olsson L, Paulsson K, Bovee J, Nord K. Clonal evolution through loss of chromosomes and subsequent polyploidization in chondrosarcoma. PLoS ONE. 2011;6:e24977 pubmed publisher
    ..tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes ..
  12. Krajarng A, Nakamura Y, Suksamrarn S, Watanapokasin R. ?-Mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway. J Agric Food Chem. 2011;59:5746-54 pubmed publisher
    b>Chondrosarcoma is a malignant primary bone tumor that is resistant to chemotherapy and radiation therapy. ?-Mangostin, a component of Garcinia mangostana Linn, is a xanthone derivative shown to have antioxidant and antitumor properties...
  13. Fong Y, Lin C, Su Y, Chen W, Tsai F, Tsai C, et al. CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells. J Cell Physiol. 2012;227:223-32 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs...
  14. Lin C, Chen H, Li T, Fong Y, Liu S, Chen P, et al. ?5 integrin up-regulation in brain-derived neurotrophic factor promotes cell motility in human chondrosarcoma. PLoS ONE. 2013;8:e67990 pubmed publisher
    b>Chondrosarcoma is a primary malignant bone cancer, with a potent capacity to invade locally and cause distant metastasis; it has a poor prognosis and shows a predilection for metastasis to the lungs...
  15. Li T, Lin T, Hsu S, Wu C, Su Y, Kao S, et al. The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells. Mol Carcinog. 2011;50:791-803 pubmed publisher
    b>Chondrosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy...
  16. Zenmyo M, Tanimoto A, Sakakima H, Yokouchi M, Nagano S, Yamamoto T, et al. Gadd45? expression in chondrosarcoma: a pilot study for diagnostic and biological implications in histological grading. Diagn Pathol. 2010;5:69 pubmed publisher
    Although the diagnosis of chondrosarcoma, especially the distinction between enchondroma and low-grade chondrosarcoma or low-grade chondrosarcoma and high-grade chondrosarcoma, is pathologically difficult, differential diagnosis is very ..
  17. Gerbers J, Jutte P. Hip-sparing approach using computer navigation in periacetabular chondrosarcoma. Comput Aided Surg. 2013;18:27-32 pubmed publisher
    b>Chondrosarcoma of the pelvis is difficult to treat due to the anatomical location and the high incidence of recurrence...
  18. Amary M, Bacsi K, Maggiani F, Damato S, Halai D, Berisha F, et al. IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J Pathol. 2011;224:334-43 pubmed publisher
    ..We speculate that a mosaic pattern of IDH-mutation-bearing cells explains the reports of diverse tumours (gliomas, AML, multiple cartilaginous neoplasms, haemangiomas) occurring in the same patient...
  19. Fox E, Patel S, Wathen J, Schuetze S, Chawla S, Harmon D, et al. Phase II study of sequential gemcitabine followed by docetaxel for recurrent Ewing sarcoma, osteosarcoma, or unresectable or locally recurrent chondrosarcoma: results of Sarcoma Alliance for Research Through Collaboration Study 003. Oncologist. 2012;17:321 pubmed publisher
    ..in children and adults with recurrent Ewing sarcoma (EWS), osteosarcoma (OS), or unresectable or recurrent chondrosarcoma. The primary objective was to determine the objective response rate using response evaluation criteria in ..
  20. Shin S, Jeong H, Han I, Cho H, Kim H. Osteosarcoma and chondrosarcoma of the shoulder: site-specific comparative analysis. Orthopedics. 2013;36:e179-85 pubmed publisher
    Osteosarcoma and chondrosarcoma compose most of the primary malignancies of the shoulder. The literature lacks site-specific comparative analyses of these 2 major shoulder sarcomas...
  21. Li T, Wu C, Huang H, Chou P, Fong Y, Tang C. Interleukin-11 increases cell motility and up-regulates intercellular adhesion molecule-1 expression in human chondrosarcoma cells. J Cell Biochem. 2012;113:3353-62 pubmed publisher
    ..Recent studies have shown that IL-11 plays a critical role in tumor growth, angiogenesis, and metastasis. Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis...
  22. de Andrea C, Hogendoorn P. Epiphyseal growth plate and secondary peripheral chondrosarcoma: the neighbours matter. J Pathol. 2012;226:219-28 pubmed publisher
    ..stem cells/wild-type chondrocytes to acquire secondary genetic changes to form a secondary peripheral chondrosarcoma. In such a scenario, the micro-environment is the site of the initiating processes that ultimately lead to ..
  23. Rakha E, Tan P, Shaaban A, Tse G, Esteller F, van Deurzen C, et al. Do primary mammary osteosarcoma and chondrosarcoma exist? A review of a large multi-institutional series of malignant matrix-producing breast tumours. Breast. 2013;22:13-8 pubmed publisher
    ..Improved understanding of the clinicopathological characteristics of primary mammary MP-sarcomas, namely osteosarcoma and chondrosarcoma, is required.
  24. Wu C, Li T, Hsu S, Su Y, Kao S, Fong Y, et al. IGF-I enhances ?5?1 integrin expression and cell motility in human chondrosarcoma cells. J Cell Physiol. 2011;226:3270-7 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs...
  25. Franchi A, Baroni G, Sardi I, Giunti L, Capanna R, Campanacci D. Dedifferentiated peripheral chondrosarcoma: a clinicopathologic, immunohistochemical, and molecular analysis of four cases. Virchows Arch. 2012;460:335-42 pubmed publisher
    Peripheral dedifferentiated chondrosarcoma (DCS) is an exceedingly rare aggressive surface bone neoplasm in which a high-grade sarcoma arises within an osteochondroma. Four such examples were identified in our files, representing 11...
  26. Im H, Li X, Chen D, Yan D, Kim J, Ellman M, et al. Biological effects of the plant-derived polyphenol resveratrol in human articular cartilage and chondrosarcoma cells. J Cell Physiol. 2012;227:3488-97 pubmed publisher
    ..cartilage in rabbit models for arthritis, but its biological effects on human articular cartilage and chondrosarcoma cells are unknown...
  27. Pontes H, Pontes F, de Abreu M, de Carvalho P, de Brito Kato A, Fonseca F, et al. Clinicopathological analysis of head and neck chondrosarcoma: three case reports and literature review. Int J Oral Maxillofac Surg. 2012;41:203-10 pubmed publisher
    b>Chondrosarcoma (CHS) is a malignant neoplasm characterized by the formation of cartilaginous matrix by neoplastic cells, with a high propensity for local recurrences...
  28. Liang X, Wang D, Wang Y, Zhou Z, Zhang J, Li J. Expression of aurora kinase A and B in chondrosarcoma and its relationship with the prognosis. Diagn Pathol. 2012;7:84 pubmed publisher
    To investigate the expression of aurora kinase A and B in patients with chondrosarcoma and consider it as a prognostic marker and molecular target of therapy.
  29. Hsu W, McCarthy E, Gokaslan Z, Wolinsky J. Clear-cell chondrosarcoma of the lumbar spine: case report and review of the literature. Neurosurgery. 2011;68:E1160-4; discussion 1164 pubmed publisher
    Clear-cell chondrosarcoma is a rare subtype of chondrosarcoma. These osseous tumors are most commonly found in the end of long bones. We report a rare case of clear-cell chondrosarcoma of the osseous spine.
  30. Sawada M, Tochigi N, Sasajima Y, Hasegawa T, Kasamatsu T, Kitawaki J. Primary extraskeletal myxoid chondrosarcoma of the vulva. J Obstet Gynaecol Res. 2011;37:1706-10 pubmed publisher
    Primary extraskeletal myxoid chondrosarcoma (EMC) of the vulva is extremely rare. There is little available information about the biological behavior and treatment strategy for primary EMC of the vulva...
  31. Cho W, Song W, Jeon D, Kong C, Koh J, Kim J, et al. Oncologic impact of the curettage of grade 2 central chondrosarcoma of the extremity. Ann Surg Oncol. 2011;18:3755-61 pubmed publisher
    Wide excision is considered the standard treatment for high-grade chondrosarcoma, but little is known regarding the effect of curettage on patient outcome in grade 2 chondrosarcoma.
  32. Wu M, Huang C, Lin J, Wang S, Peng C, Cheng H, et al. Endothelin-1 promotes vascular endothelial growth factor-dependent angiogenesis in human chondrosarcoma cells. Oncogene. 2014;33:1725-35 pubmed publisher
    b>Chondrosarcoma is the second most common sarcoma in bone malignancy and is characterized by a high metastatic potential. Angiogenesis is essential for the cancer metastasis...
  33. Tang X, Lu X, Guo W, Ren T, Zhao H, Zhao F, et al. Different expression of Sox9 and Runx2 between chondrosarcoma and dedifferentiated chondrosarcoma cell line. Eur J Cancer Prev. 2010;19:466-71 pubmed publisher
    Dedifferentiated chondrosarcoma (DDCS), a highly malignant variant of chondrosarcoma (CCS), is characterized by high-grade sarcoma adjacent to low-grade chondroid tumor...
  34. Abbas S, Vincourt J, Habib L, Netter P, Greige Gerges H, Magdalou J. The cucurbitacins E, D and I: investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver. Toxicol Lett. 2013;216:189-99 pubmed publisher
    ..The purpose of this work was to compare the cytotoxicity of three cucurbitacins I, D, E on the chondrosarcoma SW 1353 cancer cell line and to investigate their biotransformation in man...
  35. Sha B, Gao W, Han Y, Wang S, Wu J, Xu F, et al. Potential application of titanium dioxide nanoparticles in the prevention of osteosarcoma and chondrosarcoma recurrence. J Nanosci Nanotechnol. 2013;13:1208-11 pubmed
    Osteosarcoma and chondrosarcoma are malignant bone tumors, and they significantly affect the life quality of patients including children and adults...
  36. Chen C, Zhou H, Wei F, Jiang L, Liu X, Liu Z, et al. Increased levels of hypoxia-inducible factor-1? are associated with Bcl-xL expression, tumor apoptosis, and clinical outcome in chondrosarcoma. J Orthop Res. 2011;29:143-51 pubmed publisher
    ..However, the underlying role of HIF-1? in human chondrosarcoma has not been well characterized...
  37. Verdegaal S, Bovee J, Pansuriya T, Grimer R, Ozger H, Jutte P, et al. Incidence, predictive factors, and prognosis of chondrosarcoma in patients with Ollier disease and Maffucci syndrome: an international multicenter study of 161 patients. Oncologist. 2011;16:1771-9 pubmed publisher
    ..Studies evaluating the predictive value of clinical symptoms for development of secondary chondrosarcoma and prognosis are lacking...
  38. Streitbuerger A, Henrichs M, Ahrens H, Lanvers Kaminzky C, Gouin F, Gosheger G, et al. Cytotoxic effect of clodronate and zoledronate on the chondrosarcoma cell lines HTB-94 and CAL-78. Int Orthop. 2011;35:1369-73 pubmed publisher
    The wide surgical tumour resection is the only effective treatment in chondrosarcoma. However, a major problem remains the high rate of local recurrences and metastases due to the lack of adjuvant therapies...
  39. Tang C, Tsai C. CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-?B signaling pathway. Biochem Pharmacol. 2012;83:335-44 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs...
  40. Hsu C, Wu M, Chen C, Tsai C, Hsu H, Tang C. AMP-activated protein kinase activation mediates CCL3-induced cell migration and matrix metalloproteinase-2 expression in human chondrosarcoma. Cell Commun Signal. 2013;11:68 pubmed publisher
    ..CCL3 has been detected in infiltrating cells and tumor cells. Chondrosarcoma is a highly malignant tumor that causes distant metastasis...
  41. Jamil N, Howie S, Salter D. Therapeutic molecular targets in human chondrosarcoma. Int J Exp Pathol. 2010;91:387-93 pubmed publisher
    ..Treatment is usually limited to surgical resection; however, survival of patients with high-grade chondrosarcoma is poor, even with wide surgical resection...
  42. Bhamra J, Alorjani M, Skinner J, Saifuddin A. Intra-articular extraskeletal myxoid chondrosarcoma of the ankle. Skeletal Radiol. 2012;41:1017-20 pubmed publisher
    We describe an extremely rare case of an intra-articular extraskeletal myxoid chondrosarcoma causing devastating destruction to the ankle joint in a 71-year-old woman, which had been originally excised as a ganglion cyst...
  43. Andreou D, Ruppin S, Fehlberg S, Pink D, Werner M, Tunn P. Survival and prognostic factors in chondrosarcoma: results in 115 patients with long-term follow-up. Acta Orthop. 2011;82:749-55 pubmed publisher
    There have been few long-term studies on the outcome of chondrosarcoma and the findings regarding prognostic factors are controversial...
  44. Wu M, Lo J, Kuo C, Lin J, Lin Y, Chen L, et al. Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways. J Cell Physiol. 2012;227:3016-26 pubmed publisher
    ..We found that treatment of human chondrosarcoma (JJ012 cells) with ET-1 increased migration and expression of matrix metalloproteinase (MMP)-13...
  45. Tang C, Chen C, Chen W, Fong Y. IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells. J Biol Chem. 2011;286:11056-66 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs...
  46. Meftah M, Schult P, Henshaw R. Long-term results of intralesional curettage and cryosurgery for treatment of low-grade chondrosarcoma. J Bone Joint Surg Am. 2013;95:1358-64 pubmed publisher
    Data regarding outcomes following intralesional curettage and cryosurgical treatment of low-grade chondrosarcoma of bone are limited...
  47. Campanacci D, Scoccianti G, Franchi A, Roselli G, Beltrami G, Ippolito M, et al. Surgical treatment of central grade 1 chondrosarcoma of the appendicular skeleton. J Orthop Traumatol. 2013;14:101-7 pubmed publisher
    Diagnosis and treatment of low-grade chondrosarcoma remain controversial...
  48. Pehlivan B, Ares C, Lomax A, Stadelmann O, Goitein G, Timmermann B, et al. Temporal lobe toxicity analysis after proton radiation therapy for skull base tumors. Int J Radiat Oncol Biol Phys. 2012;83:1432-40 pubmed publisher
    ..We analyzed clinical events with dosimetric parameters in our patients treated for skull base tumors with spot-scanning PT...
  49. Funovics P, Panotopoulos J, Sabeti Aschraf M, Abdolvahab F, Funovics J, Lang S, et al. Low-grade chondrosarcoma of bone: experiences from the Vienna Bone and Soft Tissue Tumour Registry. Int Orthop. 2011;35:1049-56 pubmed publisher
    In a retrospective single-centre study, 70 low-grade chondrosarcoma (LCS) (31 female/39 male patients with a mean age of 40 years) were reviewed to evaluate surgical management...
  50. Tarpey P, Behjati S, Cooke S, Van Loo P, Wedge D, Pillay N, et al. Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma. Nat Genet. 2013;45:923-6 pubmed publisher
    b>Chondrosarcoma is a heterogeneous collection of malignant bone tumors and is the second most common primary malignancy of bone after osteosarcoma...
  51. van Oosterwijk J, de Jong D, van Ruler M, Hogendoorn P, Dijkstra P, van Rijswijk C, et al. Three new chondrosarcoma cell lines: one grade III conventional central chondrosarcoma and two dedifferentiated chondrosarcomas of bone. BMC Cancer. 2012;12:375 pubmed publisher
    b>Chondrosarcoma is the second most common primary sarcoma of bone. High-grade conventional chondrosarcoma and dedifferentiated chondrosarcoma have a poor outcome...
  52. Angelini A, Guerra G, Mavrogenis A, Pala E, Picci P, Ruggieri P. Clinical outcome of central conventional chondrosarcoma. J Surg Oncol. 2012;106:929-37 pubmed publisher
    ..Aim of this study was to analyze (1) survival, local recurrence (LR), and metastasis rates between the three histological tumor grades; (2) whether type of treatment and tumor site influenced prognosis for each histologic grade...
  53. Stevens J. Swarm chondrosarcoma: a continued resource for chondroblastic-like extracellular matrix and chondrosarcoma biology research. Connect Tissue Res. 2013;54:252-9 pubmed publisher
    Since its first description over four decades ago, the Swarm chondrosarcoma (Swarm rat chondrosarcoma, SRC) remains a valuable tool for studies of chondroblastic-like extracellular matrix (ECM) biology and as an animal model of human ..
  54. Bennani Baiti I, Machado I, Llombart Bosch A, Kovar H. Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Hum Pathol. 2012;43:1300-7 pubmed publisher
    ..We also show for the first time that lysine-specific demethylase 1 is also overexpressed in chondrosarcoma, Ewing's sarcoma, and osteosarcoma wherein it localizes in cell nuclei...
  55. Goedhart L, Ploegmakers J, Kroon H, Zwartkruis E, Jutte P. The presentation, treatment and outcome of periosteal chondrosarcoma in the Netherlands. Bone Joint J. 2014;96-B:823-8 pubmed publisher
    In this case study, we describe the clinical presentation and treatment of 36 patients with periosteal chondrosarcoma collected over a 59-year period by the archive of the Netherlands Committee on Bone Tumours...
  56. Sun X, Charbonneau C, Wei L, Yang W, Chen Q, Terek R. CXCR4-targeted therapy inhibits VEGF expression and chondrosarcoma angiogenesis and metastasis. Mol Cancer Ther. 2013;12:1163-70 pubmed publisher
    b>Chondrosarcoma is notable for its lack of response to conventional cytotoxic chemotherapy, propensity for developing lung metastases, and poor survival. Therefore, a better understanding of angiogenic and metastatic pathways is needed...
  57. Matsukuma S, Hisaoka M, Obara K, Kono T, Takeo H, Sato K, et al. Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion, resembling extraskeletal myxoid chondrosarcoma: Case report with a review of Literature. Pathol Int. 2012;62:817-22 pubmed publisher
    ..swollen vesicular nuclei accompanied by an abundant myxoid stroma, closely resembling extraskeletal myxoid chondrosarcoma. Tumor cells were diffusely positive for vimentin and focally positive for epithelial membrane antigen, but ..
  58. Koto K, Sakabe T, Horie N, Ryu K, Murata H, Nakamura S, et al. Chondrosarcoma from the sternum: reconstruction with titanium mesh and a transverse rectus abdominis myocutaneous flap after subtotal sternal excision. Med Sci Monit. 2012;18:CS77-81 pubmed
    b>Chondrosarcoma arising from the sternum is extremely rare and is often untreatable...
  59. Arai M, Nobusawa S, Ikota H, Takemura S, Nakazato Y. Frequent IDH1/2 mutations in intracranial chondrosarcoma: a possible diagnostic clue for its differentiation from chordoma. Brain Tumor Pathol. 2012;29:201-6 pubmed publisher
    ..Conversely, none of the ten chordomas analyzed displayed any IDH1 or IDH2 mutations. Our data suggest that the IDH1/2 mutation status could be valuable for distinguishing intracranial chondrosarcomas from chordomas...
  60. Ryu B, Himaya S, Napitupulu R, Eom T, Kim S. Sulfated chitooligosaccharide II (SCOS II) suppress collagen degradation in TNF-induced chondrosarcoma cells via NF-?B pathway. Carbohydr Res. 2012;350:55-61 pubmed publisher
    ..the expressions of collagenases 1 and 3 and thereby prevented TNF-? induced degradation of collagen in human chondrosarcoma cells (SW-1353)...
  61. Lee C, Su M, Huang C, Chen M, Hsu H, Lin C, et al. Macrophage migration inhibitory factor increases cell motility and up-regulates ?v?3 integrin in human chondrosarcoma cells. J Cell Biochem. 2012;113:1590-8 pubmed publisher
    ..Recent studies have shown that MIP plays a critical role in tumor growth, angiogenesis, and metastasis. Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis...
  62. Lee C, Huang C, Chen M, Lin C, Hsu H, Tang C. IL-8 increases integrin expression and cell motility in human chondrosarcoma cells. J Cell Biochem. 2011;112:2549-57 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumor with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs...
  63. Yang W, Fong Y, Lee C, Jin T, Tzen J, Li T, et al. Epigallocatechin-3-gallate induces cell apoptosis of human chondrosarcoma cells through apoptosis signal-regulating kinase 1 pathway. J Cell Biochem. 2011;112:1601-11 pubmed publisher
    b>Chondrosarcoma is a malignant primary bone tumor that responds poorly to both chemotherapy and radiation therapy...
  64. Hickey M, Farrokhyar F, Deheshi B, Turcotte R, Ghert M. A systematic review and meta-analysis of intralesional versus wide resection for intramedullary grade I chondrosarcoma of the extremities. Ann Surg Oncol. 2011;18:1705-9 pubmed publisher
    The surgical management of grade I intramedullary chondrosarcoma of bone remains controversial...
  65. Nikoghosyan A, Rauch G, Munter M, Jensen A, Combs S, Kieser M, et al. Randomised trial of proton vs. carbon ion radiation therapy in patients with low and intermediate grade chondrosarcoma of the skull base, clinical phase III study. BMC Cancer. 2010;10:606 pubmed publisher
    ..About 5-12% of all chondrosarcomas are localized in base of skull region. Low grade chondrosarcoma has a low incidence of distant metastasis but is potentially lethal disease...
  66. Hou C, Yang R, Hou S, Tang C. TNF-? increases ?v?3 integrin expression and migration in human chondrosarcoma cells. J Cell Physiol. 2011;226:792-9 pubmed publisher
    b>Chondrosarcoma is a type of highly malignant tumour with a potent capacity to invade locally and cause distant metastasis. Chondrosarcoma shows a predilection for metastasis to the lungs...
  67. Potluri S, Jefferies S, Jena R, Harris F, Burton K, Prevost A, et al. Residual postoperative tumour volume predicts outcome after high-dose radiotherapy for chordoma and chondrosarcoma of the skull base and spine. Clin Oncol (R Coll Radiol). 2011;23:199-208 pubmed publisher
    ..This study reviewed our outcomes, in relation to residual tumour volume and radiation dose, in order to inform our future practice...