osteochondroma

Summary

Summary: A cartilage-capped benign tumor that often appears as a stalk on the surface of bone. It is probably a developmental malformation rather than a true neoplasm and is usually found in the metaphysis of the distal femur, proximal tibia, or proximal humerus. Osteochondroma is the most common of benign bone tumors.

Top Publications

  1. Grivas T, Polyzois V, Xarchas K, Liapi G, Korres D. Seventh cervical vertebral body solitary osteochondroma. Report of a case and review of the literature. Eur Spine J. 2005;14:795-8 pubmed
    Solitary osteochondroma of the cervical spine is a rare manifestation of a common bony tumour. It can create symptoms, depending on the adjacent compressed structures...
  2. Ermis M, Aykut U, Durakbasa M, Ozel M, Bozkuş F, Karakas E. Snapping scapula syndrome caused by subscapular osteochondroma. Eklem Hastalik Cerrahisi. 2012;23:40-3 pubmed
    ..This study aims to evaluate the results of surgical excisions of subscapular exostoses which caused snapping scapula syndrome...
  3. Singh R, Sharma A, Magu N, Kaur K, Sen R, Magu S. Extraskeletal osteochondroma in the nape of the neck: a case report. J Orthop Surg (Hong Kong). 2006;14:192-5 pubmed
    Extraskeletal osteochondroma in the nape of the neck is rare and its pathological diagnosis is based on radiological and histopathological examination...
  4. Hameetman L, David G, Yavas A, White S, Taminiau A, Cleton Jansen A, et al. Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas. J Pathol. 2007;211:399-409 pubmed
    ..We hypothesize that loss of EXT expression disrupts the function of the EXT1/2 complex in HSPG biosynthesis, resulting in the intracellular accumulation of HSPG core proteins that we found in these tumours...
  5. Maheshwari A, Muro Cacho C, Pitcher J. Extraskeletal para-articular osteochondroma of the posterior knee. J Knee Surg. 2009;22:30-3 pubmed
    ..Although the knee is a common location for extraskeletal para-articular osteochondroma, it has not been described arising in the posterior aspect of the knee...
  6. Fukunaga S, Futani H, Yoshiya S. Endoscopically assisted resection of a scapular osteochondroma causing snapping scapula syndrome. World J Surg Oncol. 2007;5:37 pubmed
    b>Osteochondroma is the most common benign bone tumor in the scapula. This condition might lead to snapping scapula syndrome, which is characterized by painful, audible, and/or palpable abnormal scapulothoracic motion...
  7. Glick R, Khaldi L, Ptaszynski K, Steiner G. Dysplasia epiphysealis hemimelica (Trevor disease): a rare developmental disorder of bone mimicking osteochondroma of long bones. Hum Pathol. 2007;38:1265-72 pubmed
    ..After 4 to 5 years of age, the lesions histologically resemble osteochondroma. To our knowledge, only one publication of this entity is available in an English pathology journal...
  8. Villanueva J, Gonzalez A, Cornejo M, Núñez C, Encina S. Osteochondroma of the coronoid process. Med Oral Patol Oral Cir Bucal. 2006;11:E289-91 pubmed
    b>Osteochondroma is the most common benign neoplasia of the skeleton. In the head it was been described in cranial base, posterior maxillary surface, maxillary sinus, and different mandibular areas like condyle, ramus, body and symphysis...
  9. Nogier A, De Pinieux G, Hottya G, Anract P. Case reports: enlargement of a calcaneal osteochondroma after skeletal maturity. Clin Orthop Relat Res. 2006;447:260-6 pubmed
    Growth or radiologic modification of an osteochondroma after the epiphyseal plate closes suggests the diagnosis of malignant transformation to a chondrosarcoma...

More Information

Publications62

  1. Helpert C, Davies A, Evans N, Grimer R. Differential diagnosis of tumours and tumour-like lesions of the infrapatellar (Hoffa's) fat pad: pictorial review with an emphasis on MR imaging. Eur Radiol. 2004;14:2337-46 pubmed
    ..This pictorial review illustrates the spectrum of mass-like lesions that can affect the IFP, emphasizing the radiographic and MR findings that suggest a specific diagnosis...
  2. Kim W, Kim K, Lee S, Choy W. Solitary pelvic osteochondroma causing L5 nerve root compression. Orthopedics. 2009;32:922 pubmed publisher
    b>Osteochondroma is the most common benign bone tumor, accounting for more than one-third of all benign bone tumors. It usually develops at the metaphysis of the long bones, especially the distal femur and proximal tibia...
  3. Petratos D, Bakogiannis K, Anastasopoulos J, Matsinos G, Bessias N. Popliteal artery pseudoaneurysm secondary to osteochondroma in children and adolescents: a case report and literature review. J Surg Orthop Adv. 2009;18:205-10 pubmed
    b>Osteochondroma is the most frequent bone tumor and can rarely cause vascular complications. False aneurysms of the popliteal artery due to an osteochondroma are not common in the pediatric population...
  4. Takeuchi H, Ito K, Ogino T, Hasegawa T, Kitamura M, Ishii S. A case of osteocartilaginous mass involving the coronoid process of the ulna: solitary osteochondroma or dysplasia epiphysealis hemimelica?. J Shoulder Elbow Surg. 2003;12:510-3 pubmed
  5. Vanhegan I, Shehzad K, Bhatti T, Waters T. Acute popliteal pseudoaneurysm rupture secondary to distal femoral osteochondroma in a patient with hereditary multiple exostoses. Ann R Coll Surg Engl. 2012;94:e134-6 pubmed publisher
    ..Pseudoaneurysms usually present as an enlarging mass behind the knee. Acute rupture of an occult popliteal pseudoaneurysm caused by a distal femoral exostosis has not been reported previously...
  6. Rizzello G, Franceschi F, Meloni M, Cristi E, Barnaba S, Rabitti C, et al. Para-articular osteochondroma of the knee. Arthroscopy. 2007;23:910.e1-4 pubmed
    ..Patients with these lesions are currently treated with the use of marginal resection or excision...
  7. Hameetman L, Szuhai K, Yavas A, Knijnenburg J, van Duin M, van Dekken H, et al. The role of EXT1 in nonhereditary osteochondroma: identification of homozygous deletions. J Natl Cancer Inst. 2007;99:396-406 pubmed
    ..We examined whether EXT1 might act as a classical tumor suppressor gene for nonhereditary osteochondromas...
  8. Tian Y, Yuan W, Chen H, Shen X. Spinal cord compression secondary to a thoracic vertebral osteochondroma. J Neurosurg Spine. 2011;15:252-7 pubmed publisher
    The authors describe a case of spinal cord compression due to an osteochondroma arising from the T-6 vertebral body in a patient with hereditary multiple exostoses. This 16-year-old boy presented with spastic paraparesis...
  9. Samartzis D, Marco R. Osteochondroma of the sacrum: a case report and review of the literature. Spine (Phila Pa 1976). 2006;31:E425-9 pubmed
    ..A case report and review of the literature...
  10. Joshi D, Kumar N, Singh D, Lal Y, Singh A. Osteochondroma of the talus in a male adolescent. J Am Podiatr Med Assoc. 2005;95:494-6 pubmed
    b>Osteochondroma of the talus is rare but must be considered as part of the differential diagnosis of any swelling in this part of the skeleton...
  11. Fiechtl J, Masonis J, Frick S. Spinal osteochondroma presenting as atypical spinal curvature: a case report. Spine (Phila Pa 1976). 2003;28:E252-5 pubmed
    ..The case of an 8-year-old girl with hereditary multiple exostosis presenting with atypical spinal curvature is reported...
  12. Becelli R, Saltarel A, Santamaria S, Mastellone P, Gwanmesia I, Cianfrone F, et al. A case report of osteochondroma of the frontotemporosphenoidal suture. J Exp Clin Cancer Res. 2004;23:147-51 pubmed
    b>Osteochondroma, also known as osteocartilaginous exostosis, is the most frequent benign bone tumour of the skeletal system...
  13. Koenig S, Toth A, Martinez S, Fletcher J, Goldner R. Traumatic pseudoaneurysm of the brachial artery caused by an osteochondroma, mimicking biceps rupture in a weightlifter: a case report. Am J Sports Med. 2004;32:1049-53 pubmed
  14. Bozkurt M, Dogan M, Turanli S. Osteochondroma leading to proximal tibiofibular synostosis as a cause of persistent ankle pain and lateral knee pain: a case report. Knee Surg Sports Traumatol Arthrosc. 2004;12:152-4 pubmed
    ..This paper presents a case report of persistent ankle pain and lateral knee pain due to existing proximal tibiofibular synostosis...
  15. Rupprecht M, Mladenov K, Stücker R. Posttraumatic popliteal pseudoaneurysm caused by a femoral osteochondroma. J Pediatr Orthop B. 2010;19:341-3 pubmed publisher
    We report an exceptional case of a 12-year-old-boy with a pseudoaneurysm of the popliteal artery caused by an osteochondroma on the lower femoral metaphysic after a hyperextension trauma...
  16. Krishna Swaroop D, Bai S, Shanthi V, Ramakrishna B. Osteochondroma-like parosteal osteosarcoma. Indian J Pathol Microbiol. 2008;51:58-60 pubmed
    ..It was mistaken for osteochondroma in the initial biopsy, and the possibility of bizarre parosteal osteochondromatous proliferation (BPOP) was ..
  17. Malik R, Kapoor N, Malik R. Transformation of solitary osteochondroma calcaneum to chondrosarcoma--a case report. Indian J Pathol Microbiol. 2004;47:42-3 pubmed
    Solitary osteochondroma of calcaneum is an uncommon benign tumor. Its malignant transformation to chondrosarcoma is rarely encountered. Pain and recent enlargement are clinical manifestations of this complication...
  18. Oliva F, Marconi A, Fratoni S, Maffulli N. Extra-osseous osteochondroma-like soft tissue mass of the patello-femoral space. BMC Musculoskelet Disord. 2006;7:57 pubmed
    ..Extraskeletal cartilaginous tumors are uncommon. Osteochondromas usually arise from the metaphyseal region of the growing skeleton...
  19. Tomo H, Ito Y, Aono M, Takaoka K. Chest wall deformity associated with osteochondroma of the scapula: a case report and review of the literature. J Shoulder Elbow Surg. 2005;14:103-6 pubmed
  20. Sheff J, Wang S. Extraskeletal osteochondroma of the foot. J Foot Ankle Surg. 2005;44:57-9 pubmed
    An extraskeletal osteochondroma is an infrequently encountered benign cartilaginous tumor with a predilection for the hands and feet that usually does not exceed 3 cm in diameter...
  21. Li Y, Dang T, Shen J, Perlaky L, Hicks J, Murray J, et al. Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. Proteomics. 2006;6:3426-35 pubmed
    ..detect OS, we used SELDI MS to perform proteomic profiling on plasma specimens from 29 OS and 20 age-matched osteochondroma (OC) patients...
  22. Tobias A, Chang B. A rare brachial artery pseudoaneurysm 13 years after excision of a humeral osteochondroma. Ann Plast Surg. 2004;52:419-22 pubmed
    ..the third known report in the English literature of a brachial artery pseudoaneurysm associated with a humeral osteochondroma. In patients presenting with a painful upper arm mass and a history of multiple hereditary exostoses, one must ..
  23. Arkader A, Dormans J, Gaugler R, Davidson R. Spontaneous regression of solitary osteochondroma: reconsidering our approach. Clin Orthop Relat Res. 2007;460:253-7 pubmed
    ..We report a case of spontaneous regression of a solitary osteochondroma and review the literature...
  24. Padhya T, Athavale S, Kathju S, Sarkar S, Mehta A. Osteochondroma of the skull base. Otolaryngol Head Neck Surg. 2007;137:166-8 pubmed
  25. Esenkaya I. Pseudowinging of the scapula due to subscapular osteochondroma. Orthopedics. 2005;28:171-2 pubmed
  26. Alonso Torres A, Bernabeu D, Lopez Barea F, Martin Hervas C, González López J. Growth and fracture of an osteochondroma in an adult patient. Eur Radiol. 2004;14:2366-7 pubmed
  27. de Andrea C, Wiweger M, Prins F, Bovee J, Romeo S, Hogendoorn P. Primary cilia organization reflects polarity in the growth plate and implies loss of polarity and mosaicism in osteochondroma. Lab Invest. 2010;90:1091-101 pubmed publisher
    ..and bone growth, little is known about the organization of primary cilia in the growth plate cartilage and osteochondroma. Osteochondromas are bone tumors formed along the growth plate, and they are caused by mutations in EXT1 or ..
  28. Liu Z, Zhao Q, Zhang L. Extraskeletal osteochondroma near the hip: a pediatric case. J Pediatr Orthop B. 2010;19:524-8 pubmed publisher
    Extraskeletal osteochondroma near the hip is rare and its pathological diagnosis is based on radiological and histopathological examination...
  29. Chatzidakis E, Lypiridis S, Kazdaglis G, Chatzikonstadinou K, Papatheodorou G. A rare case of solitary osteochondroma of the dens of the C2 vertebra. Acta Neurochir (Wien). 2007;149:637-8 pubmed
    We report an extremely rare case of a 22-year-old man with an asymptomatic osteochondroma of the dens of C2 vertebra accidentally found during a brain CT scan examination.
  30. Taitz J, Cohn R, White L, Russell S, Vowels M. Osteochondroma after total body irradiation: an age-related complication. Pediatr Blood Cancer. 2004;42:225-9 pubmed
    The discovery of a mass lesion in a long-term cancer survivor causes significant anxiety. The causes of such a mass include benign osteochondroma, which has been reported following focal irradiation and total body irradiation (TBI).
  31. Carpintero P, Leon F, Zafra M, Montero M, Berral F. Fractures of osteochondroma during physical exercise. Am J Sports Med. 2003;31:1003-6 pubmed
    ..The mechanism responsible and the best form of treatment for fractures of osteochondromas remain unclear...
  32. Blitz N, Lopez K. Giant solitary osteochondroma of the inferior medial calcaneal tubercle: a case report and review of the literature. J Foot Ankle Surg. 2008;47:206-12 pubmed publisher
    ..b>Osteochondroma are often treated conservatively unless they become symptomatic, painful, demonstrate rapid or new growth, ..
  33. Maheshwari A, Jain A, Dhammi I. Extraskeletal paraarticular osteochondroma of the knee--a case report and tumor overview. Knee. 2006;13:411-4 pubmed
    ..We present here such an infrapatellar lesion and discuss criteria helpful in distinguishing these benign lesions from other morphological similar lesions...
  34. Aalderink K, Wolf B. Scapular osteochondroma treated with arthroscopic excision using prone positioning. Am J Orthop (Belle Mead NJ). 2010;39:E11-4 pubmed
    ..In this report, we describe the case of a woman in her mid-20s with painful scapular snapping and winging from an osteochondroma treated with arthroscopic excision using prone positioning.
  35. Yagi M, Ninomiya K, Kihara M, Horiuchi Y. Symptomatic osteochondroma of the spine in elderly patients. Report of 3 cases. J Neurosurg Spine. 2009;11:64-70 pubmed publisher
    Whereas osteochondroma is a common benign bone tumor in adolescence, it is rarely observed in elderly patients. It is unknown why osteochondromas, which usually develop during skeletal growth, rarely develop in elderly patients...
  36. Faik A, Mahfoud Filali S, Lazrak N, El Hassani S, Hajjaj Hassouni N. Spinal cord compression due to vertebral osteochondroma: report of two cases. Joint Bone Spine. 2005;72:177-9 pubmed
    b>Osteochondroma, or exostosis, is the most common of all benign bone tumors. Spinal osteochondromas are uncommon but may cause neurological compromise. We report two cases of spinal cord compression by osteochondromas...
  37. Inoue T, Takahashi N, Murakami K, Nishimura S, Kaimori M, Nishijima M. Osteochondroma of the sella turcica presenting with intratumoral hemorrhage. Neurol Med Chir (Tokyo). 2009;49:37-41 pubmed
    A 29-year-old man presented with a primary sellar turcica osteochondroma manifesting as intratumoral hemorrhage mimicking pituitary apoplexy. The patient suffered sudden onset of headache concomitant with vision loss in the left eye...
  38. Brastianos P, Pradilla G, McCarthy E, Gokaslan Z. Solitary thoracic osteochondroma: case report and review of the literature. Neurosurgery. 2005;56:E1379; discussion E1379 pubmed
    ..We report a case of a thoracic solitary osteochondroma arising from within the vertebral body, review the cases reported in the literature, and propose ..
  39. Rybak L, Abramovici L, Kenan S, Posner M, Bonar F, Steiner G. Cortico-medullary continuity in bizarre parosteal osteochondromatous proliferation mimicking osteochondroma on imaging. Skeletal Radiol. 2007;36:829-34 pubmed
    ..It is believed that florid reactive periostitis, BPOP and turret osteochondroma may reflect points along the same continuum with trauma the likely inciting event...
  40. Karakurt L, Yilmaz E, Varol T, Ozdemir H, Serin E. [Solitary osteochondroma of the elbow causing ulnar nerve compression: a case report]. Acta Orthop Traumatol Turc. 2004;38:291-4 pubmed
    We report ulnar nerve compression caused by solitary osteochondroma of the right elbow in a 34-year-old man. Two osteochondromas were detected originating from the olecranon and medial humeral epicondyle, respectively...
  41. Gille O, Pointillart V, Vital J. Course of spinal solitary osteochondromas. Spine (Phila Pa 1976). 2005;30:E13-9 pubmed
    ..Six spinal solitary osteochondromas...
  42. Turhan E, Doral M, Atay A, Demirel M. A giant extrasynovial osteochondroma in the infrapatellar fat pad: end stage Hoffa's disease. Arch Orthop Trauma Surg. 2008;128:515-9 pubmed
    ..The osteochondroma of the infrapatellar fat pad secondary to the Hoffa's disease can be more problematic...
  43. Ek E, Slavin J, Blackney M, Powell G. Parosteal lipoma associated with an underlying osteochondroma arising from the hallux. Skeletal Radiol. 2007;36:689-92 pubmed
    ..There have been no reported cases of such lesions arising in the foot. Hence, we report the first case of a parosteal lipoma arising in the great toe in association with an underlying osteochondroma.
  44. Giudicissi Filho M, de Holanda C, Borba L, Rassi Neto A, Ribeiro C, de Oliveira J. Cervical spinal cord compression due to an osteochondroma in hereditary multiple exostosis: case report and review of the literature. Surg Neurol. 2006;66 Suppl 3:S7-S11 pubmed
    ..The objective of this manuscript is to describe a rare case of cervical myelopathy due to an exostosis arising from C7 in a patient with HME and a comprehensive review of the current literature...
  45. Joseph J, Ritchie D, MacDuff E, Mahendra A. Bizarre parosteal osteochondromatous proliferation: a locally aggressive benign tumor. Clin Orthop Relat Res. 2011;469:2019-27 pubmed publisher
    ..Bizarre parosteal osteochondromatous proliferation (BPOP) is a benign lesion of bone, and numerous questions remain unresolved regarding its etiology, diagnosis, and treatment...
  46. Mnif H, Koubaa M, Zrig M, Zammel N, Abid A. Peroneal nerve palsy resulting from fibular head osteochondroma. Orthopedics. 2009;32:528 pubmed publisher
    This article describes a case of a 11-year-old boy with an osteochondroma of the peroneal head causing peroneal nerve palsy. Physical examination disclosed large exostoses palpated at the right fibular head...
  47. Somerset H, Kleinschmidt DeMasters B, Rubinstein D, Breeze R. Osteochondroma of the convexity: pathologic-neuroimaging correlates of a lesion that mimics high-grade meningioma. J Neurooncol. 2010;98:421-6 pubmed publisher
    ..The mass was resected en bloc. Extensive histological sectioning revealed a benign osteochondroma predominantly composed of lobules of hypocellular cartilage...
  48. Gurkanlar D, Aciduman A, Günaydin A, Koçak H, Celik N. Solitary intraspinal lumbar vertebral osteochondroma: a case report. J Clin Neurosci. 2004;11:911-3 pubmed
    ..b>Osteochondroma should be considered while evaluating a patient with low back pain or radiculopathy without a CT or MRI ..
  49. de Andrea C, Prins F, Wiweger M, Hogendoorn P. Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. J Pathol. 2011;224:160-8 pubmed publisher
    ..Impaired biosynthesis of heparan sulphate glycosaminoglycans causes osteochondroma, the most common bone tumour to occur during adolescence...
  50. Bottner F, Rodl R, Kordish I, Winklemann W, Gosheger G, Lindner N. Surgical treatment of symptomatic osteochondroma. A three- to eight-year follow-up study. J Bone Joint Surg Br. 2003;85:1161-5 pubmed
    ..There were 40 women and 46 men with a mean age of 20 years (3 to 62). Of these, 56 had a solitary osteochondroma and 30 had multiple hereditary tumours. The presenting symptoms were pain (79.1%), swelling (23...
  51. Khare G. An analysis of indications for surgical excision and complications in 116 consecutive cases of osteochondroma. Musculoskelet Surg. 2011;95:121-5 pubmed publisher
    The indications for surgery in 116 cases of osteochondroma included cosmetic problem in 38, pain (on hitting some object or continuous pain due to bursitis) in 50, pressure (on adjacent nerves) in 18, hindrances of joint movements in 8, ..
  52. Zuntini M, Pedrini E, Parra A, Sgariglia F, Gentile F, Pandolfi M, et al. Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation. Oncogene. 2010;29:3827-34 pubmed publisher
    b>Osteochondroma, the most common benign bone tumor, may occur as a sporadic lesion or as multiple neoplasms in the context of multiple osteochondromas syndrome...
  53. Maheshwari A, Jain A, Dhammi I. Osteochondroma of C7 vertebra presenting as compressive myelopathy in a patient with nonhereditary (nonfamilial/sporadic) multiple exostoses. Arch Orthop Trauma Surg. 2006;126:654-9 pubmed
    ..To the best of our knowledge, this is the first report of an osteochondroma arising from C7 vertebra presenting with compressive myelopathy in a patient with nonhereditary multiple ..