osteoblastoma

Summary

Summary: A benign, painful, tumor of bone characterized by the formation of osteoid tissue, primitive bone and calcified tissue. It occurs frequently in the spine of young persons. (From Dorland, 27th ed; Stedman, 25th ed)

Top Publications

  1. Hermann G, Klein M, Springfield D, Abdelwahab I. Osteoblastoma like osteosarcoma. Clin Radiol. 2004;59:105-8 pubmed
  2. Lin Y, Commins D, Fedenko A, Pinsky G. A rare case of periosteal osteoblastoma located in the frontal cranial bone. Arch Pathol Lab Med. 2005;129:787-9 pubmed
    Periosteal osteoblastoma is an extremely rare bone-forming neoplasm located on the surface of cortical bone...
  3. Angiero F, Mellone P, Baldi A, Stefani M. Osteoblastoma of the jaw: report of two cases and review of the literature. In Vivo. 2006;20:665-70 pubmed
    b>Osteoblastoma is a benign bone tumor of osteoblastic origin. Two cases, an 8-year-old boy and a 24-year-old man, are presented...
  4. Capodiferro S, Maiorano E, Giardina C, Lacaita M, Lo Muzio L, Favia G. Osteoblastoma of the mandible: clinicopathologic study of four cases and literature review. Head Neck. 2005;27:616-21 pubmed
    b>Osteoblastoma is a benign bone tumor accounting for 1% of all bone tumors; it commonly involves the spine and the sacrum of young individuals, with less than 5% being localized to the posterior mandible...
  5. McHugh J, Mukherji S, Lucas D. Sino-orbital osteoma: a clinicopathologic study of 45 surgically treated cases with emphasis on tumors with osteoblastoma-like features. Arch Pathol Lab Med. 2009;133:1587-93 pubmed publisher
    ..Histologically, they can be divided into ivory, mature, or mixed types. Osteomas may have osteoblastoma-like areas and distinguishing it from true osteoblastoma can be challenging...
  6. Bilkay U, Erdem O, Ozek C, Helvaci E, Kilic K, Ertan Y, et al. A rare location of benign osteoblastoma: review of the literature and report of a case. J Craniofac Surg. 2004;15:222-5 pubmed
    Benign osteoblastoma is a rare primary bone tumor that constitutes approximately 1% of all primary bone tumors. Its occurrence in the craniomaxillofacial region as also rare and represents only 15% of all osteoblastomas...
  7. Combalia Aleu A, Popescu D, Pomes J, Palacin A. Long-standing pain in a 25-year-old patient with a non-diagnosed cervical osteoblastoma: a case report. Arch Orthop Trauma Surg. 2008;128:567-71 pubmed
    ..We present a case report of a young male that due to the lack of specific symptoms was diagnosed of a cervical osteoblastoma 14 months after the first symptoms. The tumor was located in the right C7 pedicle...
  8. Emmez H, Kaymaz M, Tokgoz N, Yilmaz G, Kurt G. Progression of a lumbar spinal osteoblastoma. Neurol Med Chir (Tokyo). 2005;45:379-83 pubmed
    A 24-year-old woman presented with a lumbar spinal osteoblastoma manifesting as a 5-year history of low back pain radiating to the left foot...
  9. Tawil A, Comair Y, Nasser H, Hourani R, Rebeiz J, Chamoun R. Periosteal osteoblastoma of the calvaria mimicking a meningioma. Pathol Res Pract. 2008;204:413-22 pubmed publisher
    While osteoblastoma of the cranial vault is rare, the periosteal form of the tumor is highly unusual, with only one case reported in the English literature. We report on a 24-year-old woman presenting with headache and tinnitus...

More Information

Publications62

  1. Atesok K, Alman B, Schemitsch E, Peyser A, Mankin H. Osteoid osteoma and osteoblastoma. J Am Acad Orthop Surg. 2011;19:678-89 pubmed
    Osteoid osteoma and osteoblastoma are commonly seen benign osteogenic bone neoplasms. Both tumors are typically seen in the second decade of life, with a notable predilection in males...
  2. Oliveira C, Mendonça B, Camargo O, Pinto E, Nascimento S, Latorre M, et al. Classical osteoblastoma, atypical osteoblastoma, and osteosarcoma: a comparative study based on clinical, histological, and biological parameters. Clinics (Sao Paulo). 2007;62:167-74 pubmed
    ..To investigate the biological behavior of classical and atypical osteoblastomas in comparison to osteosarcomas...
  3. Biagini R, Orsini U, Demitri S, Bibiloni J, Ruggieri P, Mercuri M, et al. Osteoid osteoma and osteoblastoma of the sacrum. Orthopedics. 2001;24:1061-4 pubmed
    This retrospective study examined 10 patients with osteoid osteoma and 11 patients with osteoblastoma localized in the sacrococcyx. In the sacrum, the diagnosis was delayed compared to other sites...
  4. Laban M, Riutta J. "Occult" roentgenographic osteoblastoma of the cervical spine. Am J Phys Med Rehabil. 2003;82:820-3 pubmed
    ..cervical spine computed tomography with digital reconstruction once again demonstrated the presence of an osteoblastoma. The patient was subsequently referred to a spinal surgeon for biopsy and resection, which confirmed the ..
  5. Harrop J, Schmidt M, Boriani S, Shaffrey C. Aggressive "benign" primary spine neoplasms: osteoblastoma, aneurysmal bone cyst, and giant cell tumor. Spine (Phila Pa 1976). 2009;34:S39-47 pubmed publisher
    ..Clinically based systematic review...
  6. Ramme A, Smucker J. Balancing spinal stability and future mobility in the cervical spine: surgical treatment of a case of osteoblastoma with secondary aneurysmal bone cyst. Spine J. 2011;11:e5-12 pubmed publisher
    The combination of osteoblastoma and aneurysmal bone cyst (ABC) in the cervical spine is a relatively rare occurrence in the general population...
  7. Amirjamshidi A, Abbassioun K. Osteoblastoma of the third cervical vertebra in a 16-year-old boy: case report and review of the literature. Pediatr Neurosurg. 2010;46:396-401 pubmed publisher
    BACKGROUND/SUBJECT: A rare case of osteoblastoma of the third cervical vertebra (C3) occurring in a 16-year-old adolescent is presented. He was admitted suffering from neck pain for more than 3 years.
  8. Xarchas K, Leviet D. Osteoblastoma of the carpal scaphoid frequency and treatment. Acta Orthop Belg. 2002;68:532-6 pubmed
    A rare case of osteoblastoma of the carpal scaphoid is presented. Review of the literature revealed two more cases that have been previously reported...
  9. Meade R, Allende C, Tsai T. Osteoblastoma of the scaphoid: a case report. J Surg Orthop Adv. 2005;14:125-8 pubmed
    b>Osteoblastoma is an uncommon primary bone tumor that rarely is found in the hand or wrist...
  10. González Sistal A, Baltasar Sánchez A. A complementary method for the detection of osteoblastic metastases on digitized radiographs. J Digit Imaging. 2006;19:270-5 pubmed
    ..This study was conducted to evaluate the diagnostic usefulness of gray level parameters in order to distinguish healthy bone from osteoblastic metastases on digitized radiographs...
  11. Saifuddin A, White J, Sherazi Z, Shaikh M, Natali C, Ransford A. Osteoid osteoma and osteoblastoma of the spine. Factors associated with the presence of scoliosis. Spine (Phila Pa 1976). 1998;23:47-53 pubmed
    A retrospective study of 44 museum cases of spinal osteoid osteoma or osteoblastoma and a meta-analysis using 421 additional cases from a review of the literature.
  12. Jones A, Prihoda T, Kacher J, Odingo N, Freedman P. Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:639-50 pubmed
    b>Osteoblastoma is a benign neoplasm of bone characterized by a proliferation of osteoblasts forming bone trabeculae set in a vascularized fibrous connective tissue stroma...
  13. Giannico G, Holt G, Homlar K, Johnson J, Pinnt J, Bridge J. Osteoblastoma characterized by a three-way translocation: report of a case and review of the literature. Cancer Genet Cytogenet. 2009;195:168-71 pubmed publisher
    b>Osteoblastoma, an uncommon primary bone tumor, produces both osteoid and primitive woven bone in a background of fibrovascular connective tissue...
  14. Jeong Y, Sohn M, Lim S, Kim D, Jeong H, Jang K, et al. Osteoblastoma in the nasal cavity: F-18 FDG PET/CT and Tc-99m MDP 3-phase bone scan findings with pathologic correlation. Clin Nucl Med. 2011;36:214-7 pubmed publisher
    A benign osteoblastoma of the nasal cavity is very rare. A 57-year-old woman, who had a radical hysterectomy for carcinoma of the uterine cervix 5 years ago, underwent F-18 FDG PET/CT...
  15. Lee E, Park C, Song S, Park N, Kim M. Osteoblastoma arising from the ethmoidal sinus. AJR Am J Roentgenol. 2004;182:1343-4 pubmed
  16. Arkader A, Dormans J. Osteoblastoma in the skeletally immature. J Pediatr Orthop. 2008;28:555-60 pubmed publisher
    b>Osteoblastoma is a rare benign and sometimes locally aggressive tumor with peak incidence in the second decade...
  17. Saglik Y, Atalar H, Yildiz Y, Basarir K, Gunay C. Surgical treatment of osteoblastoma : a report of 20 cases. Acta Orthop Belg. 2007;73:747-53 pubmed
    b>Osteoblastoma is a locally aggressive osteoblastic lesion of bone with rare malignant transformation. We retrospectively evaluated 20 patients who were diagnosed and surgically treated for osteoblastoma in our institution...
  18. Woźniak A, Nowaczyk M, Osmola K, Golusinski W. Malignant transformation of an osteoblastoma of the mandible: case report and review of the literature. Eur Arch Otorhinolaryngol. 2010;267:845-9 pubmed publisher
    Benign osteoblastoma is a rarely seen tumor of the facial bones. The authors present a case of a 30-year-old man with a tumor of the mandibular body and ramus. The histopathological diagnosis was one of osteoblastoma...
  19. Baker A, Rezeanu L, Klein M, Pitt M, Buecker P, Hersh J, et al. Aggressive osteoblastoma: a case report involving a unique chromosomal aberration. Int J Surg Pathol. 2010;18:219-24 pubmed publisher
    ..with clinical history, radiology, and histology is not carefully considered or if the several variants of osteoblastoma are not recognized...
  20. Lian X, Zhao J, Hou T, Ma H, Chen Z. Benign intraspinal osteoblastoma stemming from C7 lamina in cervicothoracic junction: a case report. Spine (Phila Pa 1976). 2006;31:E895-9 pubmed
    A case report of a rare benign osteoblastoma successfully treated with total en bloc excision.
  21. Muzumdar D, Balasubramaniam S, Jhawar S, Goel A. Massive benign osteoblastoma of the suboccipital bone and foramen magnum region. Pediatr Neurosurg. 2010;46:232-7 pubmed publisher
    Benign osteoblastoma is an uncommon primary bone tumor frequently found in the vertebral column and long tubular bones, and rarely occurring in the calvarium...
  22. Young E, Dabrowski M, Brelsford K. Osteoblastoma of the nasal septum. J Laryngol Otol. 2011;125:1062-6 pubmed publisher
    To present a case of, and to review the literature concerning, osteoblastoma of the nasal cavity, and to demonstrate the importance of considering this rare entity when assessing patients presenting with a nasal septum lesion.
  23. Samdani A, Torre Healy A, Chou D, Cahill A, Storm P. Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature. Eur Spine J. 2009;18 Suppl 2:196-200 pubmed publisher
    b>Osteoblastoma is a rare benign bone tumor that presents with back pain and occurs in the spine approximately 40% of the time...
  24. von Chamier G, Holl Wieden A, Stenzel M, Raab P, Darge K, Girschick H, et al. Pitfalls in diagnostics of hip pain: osteoid osteoma and osteoblastoma. Rheumatol Int. 2010;30:395-400 pubmed publisher
    Osteoid osteoma and osteoblastoma are benign bone tumors that occur most often in adolescents and predominantly in males...
  25. Burn S, Ansorge O, Zeller R, Drake J. Management of osteoblastoma and osteoid osteoma of the spine in childhood. J Neurosurg Pediatr. 2009;4:434-8 pubmed publisher
    Osteoid osteomas and osteoblastoma of the spine are rare lesions in childhood, and management strategies have changed...
  26. Cleton Jansen A, Anninga J, Briaire de Bruijn I, Romeo S, Oosting J, Egeler R, et al. Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. Br J Cancer. 2009;101:1909-18 pubmed publisher
    ..To identify the signalling pathways involved in tumourigenesis, we compared gene expression in osteosarcoma with that in its presumed normal counterparts...
  27. Poleksić Z, Lalosević V, Milinković Z. Osteoblastoma of the spine. Acta Chir Iugosl. 2010;57:63-8 pubmed
    ..5%) pati-ents. Clearly delineated lesions were treated by an intralesional procedure, but aggressive ones were treated by a marginal surgery followed by additional radiotherapy (6 patients). The average follow-up period was 13 years...
  28. Jambhekar N, Desai S, Khapake D. Osteoblastoma: a study of 12 cases. Indian J Pathol Microbiol. 2006;49:487-90 pubmed
    This study comprises of 12 cases of osteoblastoma. There were 8 males and 4 females, with a mean age of 17.8 years. The vertebral column, including the sacrum was the most frequent site (10 of 12 cases)...
  29. Berry M, Mankin H, Gebhardt M, Rosenberg A, Hornicek F. Osteoblastoma: a 30-year study of 99 cases. J Surg Oncol. 2008;98:179-83 pubmed publisher
    b>Osteoblastoma is a rare, bone-forming neoplasm accounting for 1% of primary bone tumors. It arises in young patients and develops in long bones and posterior elements of the spine...
  30. Rawal Y, Angiero F, Allen C, Kalmar J, Sedghizadeh P, Steinhilber A. Gnathic osteoblastoma: clinicopathologic review of seven cases with long-term follow-up. Oral Oncol. 2006;42:123-30 pubmed
    The clinical, radiographic and histopathologic features of seven cases of osteoblastoma of the jaw bones were analyzed. The mandible was involved in six cases and a periosteal presentation of the tumor was noted in three cases...
  31. Boriani S, Amendola L, Bandiera S, Simoes C, Alberghini M, Di Fiore M, et al. Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases. Eur Spine J. 2012;21:2003-10 pubmed publisher
    To define the role of Enneking staging system and of the consequent different treatment options on the outcome of osteoblastoma (OBL) of the spine.
  32. Kan P, Schmidt M. Osteoid osteoma and osteoblastoma of the spine. Neurosurg Clin N Am. 2008;19:65-70 pubmed
    ..The authors review the clinical presentation, radiologic findings, and treatment in osteoid osteoma and osteoblastoma of the spine, with an emphasis on surgical management and outcomes in recent years.
  33. Lucas D. Osteoblastoma. Arch Pathol Lab Med. 2010;134:1460-6 pubmed publisher
    b>Osteoblastoma is a rare benign bone tumor. Although the histologic features in most cases are distinctive, there are various permutations that make the diagnosis challenging...
  34. Trübenbach J, Nagele T, Bauer T, Ernemann U. Preoperative embolization of cervical spine osteoblastomas: report of three cases. AJNR Am J Neuroradiol. 2006;27:1910-2 pubmed
    ..The postoperative course was uneventful in all patients. Preoperative embolization is a valuable adjunct to the surgical treatment of osteoblastomas of the cervical spine...
  35. Alvares Capelozza A, Gião Dezotti M, Casati Alvares L, Negrão Fleury R, Sant Ana E. Osteoblastoma of the mandible: systematic review of the literature and report of a case. Dentomaxillofac Radiol. 2005;34:1-8 pubmed
    Benign osteoblastoma is a bone tumour that seldom occurs in the facial bones...
  36. Gordon S, MacIntosh R, Wesley R. A review of osteoblastoma and case report of metachronous osteoblastoma and unicystic ameloblastoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:570-5 pubmed
    A case is reported of a young woman who, within a 2-year period, was diagnosed with an osteoblastoma at the apex of a maxillary molar and with a plexiform unicystic ameloblastoma in the posterior mandible...
  37. Tarantino R, Piccirilli M, Anichini G, Delfini R. Benign osteoblastoma of the odontoid process of the axis with secondary aneurysmal bone cyst component: a case report. Neurosurg Rev. 2008;31:111-5 pubmed
    ..The histological examination revealed an osteoblastoma of the odontoid process of the axis with a secondary aneurysmal bone cyst...
  38. Chakrapani S, Grim K, Kaimaktchiev V, Anderson J. Osteoblastoma of the spine with discordant magnetic resonance imaging and computed tomography imaging features in a child. Spine (Phila Pa 1976). 2008;33:E968-70 pubmed publisher
    ..Case report...
  39. Caltabiano R, Serra A, Bonfiglio M, Platania N, Albanese V, Lanzafame S, et al. A rare location of benign osteoblastoma: case study and a review of the literature. Eur Rev Med Pharmacol Sci. 2012;16:1891-4 pubmed
    b>Osteoblastoma is a solitary, benign bone tumor that is rarely localized in the frontal sinus. It consists of hypocellular mineralized tissue that may form large masses or irregular trabeculae...
  40. Mavrogenis A, Valencia J, Romagnoli C, Guerra G, Ruggieri P. Tumors of the coracoid process: clinical evaluation of twenty-one patients. J Shoulder Elbow Surg. 2012;21:1508-15 pubmed publisher
    ..We present the incidence and management of bone tumors of the coracoid process and discuss the related clinical and imaging findings and treatment...
  41. Mirbagheri N, Galloway S, Iseli T, Lyons B. Extraosseous osteoblastoma of larynx presenting with acute airway obstruction. J Laryngol Otol. 2008;122:1265-8 pubmed publisher
    We report the case of an osteoblastoma of the larynx arising from the vocal fold, which presented with acute airway obstruction and cardiopulmonary arrest.
  42. Yazici Z, Yazici B, Yalcinkaya U, Gokalp G. Sino-orbital osteoma with osteoblastoma-like features: case reports. Neuroradiology. 2012;54:765-9 pubmed publisher
    Most of the orbital osteomas arise from the adjacent paranasal sinuses. Some of them may contain osteoblastoma-like areas and may be misdiagnosed as osteoblastoma, both radiologically as well as histopathologically...
  43. Ehlinger M, Cognet J, Chiffolot X, Marcellin L, Simon P. [Epiphyseal tibial osteoblastoma: report of a rare localization and review of the literature]. Rev Chir Orthop Reparatrice Appar Mot. 2003;89:266-71 pubmed
    b>Osteoblastoma is an uncommon benign bone tumor diagnosed in about 1% of primary bone tumors...
  44. Hamza S, Landolsi F, Meddeb N, Chelaïfa K, Sahli H, Cheour E, et al. [An unusual cause of secondary scoliosis: vertebral osteoblastoma]. Tunis Med. 2004;82:65-8 pubmed
    ..The clinical examination shows a scoliosis. Imaging suggests either malignant tumor or an aggressive osteoblastoma of the sixth thoracic vertebra...
  45. Glazer T, Spector M, McHugh J, Hogikyan N. Osteoblastoma of the thyroid cartilage treated with voice preserving laryngeal framework resection. Laryngoscope. 2013;123:1948-51 pubmed publisher
    b>Osteoblastoma is a slow-growing, locally destructive benign bone neoplasm, rarely occurring in the laryngeal cartilage...
  46. Sheah K, Peh W, Tan S. A 16-year-old boy with back pain. Am J Orthop (Belle Mead NJ). 2002;31:101-4 pubmed
    ..This case is presented to illustrate the imaging and clinical findings of a condition of interest to orthopaedic surgeons. The initial findings are noted on this page. The clinical and imaging diagnoses are presented on the following pages...
  47. Saghieh S, Rameh C, Birjawi G, Lakkis S. Sacral osteoblastoma presenting as a L5-S1 disc herniation. Int Surg. 2005;90:289-92 pubmed
    b>Osteoblastoma is an uncommon neoplasm of the bone accounting for only 0.5-2% of all primary bone tumors. It constitutes 9% of all primary bone tumors arising in the sacrum...
  48. Horvai A, Unni K. Premalignant conditions of bone. J Orthop Sci. 2006;11:412-23 pubmed
  49. Abbott M, Lefton D, Abbott R, Jallo G. Images in pediatric neurosurgery. Osteoblastoma. Pediatr Neurosurg. 2003;39:279-81 pubmed
  50. Kawamoto K, Inagaki T, Tsukazaki Y, Ryu T, Uemura Y, Sakaida Y, et al. [Clinico-pathology of skull tumor: osteoma, osteoblastoma, osteosarcoma]. No Shinkei Geka. 2004;32:549-56 pubmed
  51. Yang J, Zhang X, Liu J, Ding Y, Gao F, Wang Y. [Expression and significance of N-cadherin and ?-catenin protein in osteosarcoma]. Zhonghua Zhong Liu Za Zhi. 2010;32:586-9 pubmed
    ..To evaluate the expression of N-cadherin and ?-catenin protein and their relationship with clinicopathological characteristics of osteosarcoma...
  52. Charfi S, Khabir A, Ayadi L, Makni S, Toumi N, Frikha M, et al. [Primary osteoblastoma-like osteosarcoma of the sternum: a case report]. Presse Med. 2007;36:253-4 pubmed
  53. Kaya I, Boynuk B, Günerbuyuk C, Ugras A. Osteoblastoma of the trapezoid bone and triquetral bone: report of two cases. Acta Orthop Traumatol Turc. 2013;47:376-8 pubmed
    b>Osteoblastoma is a benign local aggressive tumor mostly localized in the vertebra or long bones. Carpal location and recurrence are extremely rare...