ossifying fibroma

Summary

Summary: A benign central bone tumor, usually of the jaws (especially the mandible), composed of fibrous connective tissue within which bone is formed.

Top Publications

  1. Granados R, Carrillo R, Najera L, Garcia Villanueva M, Patron M. Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:614-9 pubmed
    To clarify the role of immunohistochemistry in the diagnosis of psammomatoid ossifying fibroma (PSOF), conventional cemento-ossifying fibroma (COF), and psammomatous meningioma (PM) of the craniofacial skeleton.
  2. Yazgan C, Fitoz S, Atasoy P, Akyar S. [Case report: Cemento-ossifying fibroma of the ethmoidal sinus presenting with exophthalmos]. Tani Girisim Radyol. 2003;9:192-4 pubmed
    Cemento-ossifying fibroma is a benign fibro-osseous tumor which contains fibrous tissue and varying amounts of calcified tissue resembling bone, cementum or both...
  3. Hasselblatt M, Jundt G, Greiner C, Rama B, Schmäl F, Iglesias Rozas J, et al. Juvenile psammomatoid ossifying fibroma of the neurocranium. Report of four cases. J Neurosurg. 2005;102:1151-4 pubmed
    Juvenile psammomatoid ossifying fibroma (JPOF) is a benign fibroosseous lesion predominantly arising within the paranasal sinuses in children and young adults...
  4. Araki M, Matsumoto K, Matsumoto N, Honda K, Ohki H, Komiyama K. Unusual radiographic appearance of ossifying fibroma in the left mandibular angle. Dentomaxillofac Radiol. 2010;39:314-9 pubmed publisher
    b>Ossifying fibroma is usually a unilocular lesion with a well-defined, thinly corticated margin radiographically, although various patterns have been noted...
  5. Yadav R, Gulati A. Peripheral ossifying fibroma: a case report. J Oral Sci. 2009;51:151-4 pubmed
    A case of peripheral ossifying fibroma (POF) in the mandibular gingiva of a 30-year-old man is described...
  6. Sarwar H, Jindal M, Ahmad S. Cemento-ossifying fibroma--a rare case. J Indian Soc Pedod Prev Dent. 2008;26:128-31 pubmed
    ..of bone has evolved over the last several decades and now includes two major entities: fibrous dysplasia and ossifying fibroma, as well as the other less common lesions such as florid osseous dysplasia, periapical dysplasia, focal ..
  7. Karkuzhali P, Gnanaguruparan A, Bhattachryya M. Psammomatoid ossifying fibroma of sinonasal tract. Otolaryngol Head Neck Surg. 2006;134:705-7 pubmed
  8. Goh E, Cho K, Lee I, Chon K. A case of isolated ossifying fibroma of the mastoid cavity of the temporal bones. Am J Otolaryngol. 2006;27:358-61 pubmed
    To describe an isolated ossifying fibroma of the mastoid cavity that did not invade the inner ear and middle ear cavity.
  9. Mintz S, Velez I. Central ossifying fibroma: an analysis of 20 cases and review of the literature. Quintessence Int. 2007;38:221-7 pubmed
    Central ossifying fibroma is the most common benign fibro-osseous neoplasm of the jaw...

More Information

Publications62

  1. Baumann I, Zimmermann R, Dammann F, Maassen M. Ossifying fibroma of the ethmoid involving the orbit and the skull base. Otolaryngol Head Neck Surg. 2005;133:158-9 pubmed
  2. Firat Y, Firat A, Karakas H, Onal C. A case of frontal lobe abscess as a complication of frontal sinus ossifying fibroma. Dentomaxillofac Radiol. 2006;35:447-50 pubmed
    Sinonasal ossifying fibroma is a rare, slow-growing, benign bony tumour, frequently involving the maxilla and mandible in the head and neck region...
  3. Moon W, Choi S, Chung E, Kwon K, Chae S. Peripheral ossifying fibroma in the oral cavity: CT and MR findings. Dentomaxillofac Radiol. 2007;36:180-2 pubmed
    We report a case of peripheral ossifying fibroma arising from the anterior oral cavity in a 12-year-old boy. CT and MR scans showed a large exophytic soft tissue mass overlying the anterior hard palate and maxillary alveolar ridge...
  4. Zupi A, Ruggiero A, Insabato L, Senghore N, Califano L. Aggressive cemento-ossifying fibroma of the jaws. Oral Oncol. 2000;36:129-33 pubmed
    The cemento-ossifying fibroma is probably the most frequent fibro-osseous lesion seen by oral pathologists. Occasionally, reports of lesions behaving in an aggressive fashion appear in the literature...
  5. Shekhar M, Bokhari K. Juvenile aggressive ossifying fibroma of the maxilla. J Indian Soc Pedod Prev Dent. 2009;27:170-4 pubmed publisher
    Juvenile aggressive ossifying fibroma is an uncommon and controversial, benign but aggressive osteogenic neoplasm of the jaws commonly occurring in children and young adults...
  6. Kendrick F, Waggoner W. Managing a peripheral ossifying fibroma. ASDC J Dent Child. 1996;63:135-8 pubmed
    The Peripheral Ossifying Fibroma is an inflammatory lesion which most often appears in twenty-five to thirty-four-year-old females. It averages 1.0 cm at its greatest dimension...
  7. Sun G, Chen X, Tang E, Li Z, Li J. Juvenile ossifying fibroma of the maxilla. Int J Oral Maxillofac Surg. 2007;36:82-5 pubmed
    Juvenile ossifying fibroma is a rare fibro-osseous neoplasm in young children. This lesion is locally aggressive and spreads quickly, and because it has a very high recurrence rate complete excision is essential...
  8. Khademi B, Niknejad N, Mahmoudi J. An aggressive psammomatoid ossifying fibroma of the sinonasal tract: report of a case. Ear Nose Throat J. 2007;86:400-1 pubmed
    ..Histologically they are benign, but clinically they are locally aggressive. We report the case of a 15-year-old boy who had a large APOF in the left ethmoid and sphenoid sinuses. The location of this tumor made this case unusual...
  9. Prasad S, Reddy S, Patil S, Kalburgi N, Puranik R. Peripheral ossifying fibroma and pyogenic granuloma. Are they interrelated?. N Y State Dent J. 2008;74:50-2 pubmed
    Peripheral ossifying fibroma (POF) and pyogenic granuloma (PG) belong to the group of "focal reactive overgrowths," having different histomorphologic representations. The pathogenesis of POF remains controversial...
  10. Nasser M. Psammomatoid ossifying fibroma with secondary aneurysmal bone cyst of frontal sinus. Childs Nerv Syst. 2009;25:1513-6 pubmed publisher
    Psammomatoid ossifying fibroma (POF) is a rare, slowly progressive tumor of the extragnathic craniofacial bones, with a tendency toward locally aggressive behavior.
  11. Feller L, Buskin A, Raubenheimer E. Cemento-ossifying fibroma: case report and review of the literature. J Int Acad Periodontol. 2004;6:131-5 pubmed
    ..Peripheral cemento-ossifying fibroma has been referred to by a variety of terms depending on whether it is accepted as being a true odontogenic ..
  12. Caylakli F, Buyuklu F, Cakmak O, Ozdemir H, Ozluoglu L. Ossifying fibroma of the middle turbinate: a case report. Am J Otolaryngol. 2004;25:377-8 pubmed
    ..En bloc excision was performed. Histological examination confirmed the diagnosis as OF. Our case is of particular interest because it is, to our knowledge, the first documented case of OF arising from the middle turbinate...
  13. Zama M, Gallo S, Santecchia L, Bertozzi E, De Stefano C. Juvenile active ossifying fibroma with massive involvement of the mandible. Plast Reconstr Surg. 2004;113:970-4 pubmed
    ..The parameters for the diagnosis of juvenile active ossifying fibroma are as follows: a patient under 15 years of age, localization of the tumor, the radiologic aspect, and the ..
  14. Engelbrecht V, Preis S, Hassler W, Lenard H. CT and MRI of congenital sinonasal ossifying fibroma. Neuroradiology. 1999;41:526-9 pubmed
    We report a 9-year-old boy with a sinonasal ossifying fibroma, probably congenital, with atypical findings on CT and MRI...
  15. Rinaggio J, Land M, Cleveland D. Juvenile ossifying fibroma of the mandible. J Pediatr Surg. 2003;38:648-50 pubmed
    Juvenile ossifying fibroma is a benign, but potentially aggressive, fibro-osseous tumor of the craniofacial bones...
  16. García de Marcos J, García de Marcos M, Arroyo Rodríguez S, Chiarri Rodrigo J, Poblet E. Peripheral ossifying fibroma: a clinical and immunohistochemical study of four cases. J Oral Sci. 2010;52:95-9 pubmed
    Peripheral ossifying fibroma (POF) is a lesion of the gingival tissues that predominantly affects women and is usually located in the maxilla anterior to the molars...
  17. Patil K, Mahima V, Balaji P. Juvenile aggressive cemento-ossifying fibroma. A case report. Indian J Dent Res. 2003;14:111-9 pubmed
    Juvenile Aggressive Cemento-Ossifying Fibroma is a benign, fibro osseous neoplasm commonly affected maxilla but also other bones including mandible, arising in children...
  18. Dominguete P, Meyer T, Alves F, Bittencourt W. Juvenile ossifying fibroma of the jaw. Br J Oral Maxillofac Surg. 2008;46:480-1 pubmed publisher
    Juvenile ossifying fibroma is a benign lesion with aggressive local growth. It is similar to an ossifying fibroma, although it is more aggressive and of earlier onset...
  19. Walters J, Will J, Hatfield R, Cacchillo D, Raabe D. Excision and repair of the peripheral ossifying fibroma: a report of 3 cases. J Periodontol. 2001;72:939-44 pubmed
    The peripheral ossifying fibroma (POF), one of the most common gingival lesions, has a recurrence rate of nearly 20%. To minimize the reappearance of this lesion, it must be completely excised...
  20. Hanemann J, Pereira A, Ribeiro Júnior N, Oliveira D. Peripheral ossifying fibroma in a child: report of case. J Clin Pediatr Dent. 2003;27:283-5 pubmed
    A typical peripheral ossifying fibroma in the anterior maxilla of an 11-year-old boy is presented. The importance of differential diagnosis and proper treatment for prevention of recurrence is discussed.
  21. Pimenta F, Gontijo Silveira L, Tavares G, Silva A, Perdigão P, Castro W, et al. HRPT2 gene alterations in ossifying fibroma of the jaws. Oral Oncol. 2006;42:735-9 pubmed
    b>Ossifying fibroma (OF) is a benign neoplasm related to bone characterized by a progressive enlargement of the affected jaw...
  22. Barberi A, Cappabianca S, Colella G. Bilateral cemento-ossifying fibroma of the maxillary sinus. Br J Radiol. 2003;76:279-80 pubmed
  23. Salum F, Yurgel L, Cherubini K, De Figueiredo M, Medeiros I, Nicola F. Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases. Minerva Stomatol. 2008;57:227-32 pubmed
    The present study examined retrospectively the clinical and radiographic characteristics of pyogenic granuloma (PG), peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF), located in the gingiva and alveolar ridge.
  24. Kumar S, Ram S, Jorgensen M, Shuler C, Sedghizadeh P. Multicentric peripheral ossifying fibroma. J Oral Sci. 2006;48:239-43 pubmed
    Peripheral ossifying fibroma (POF) is a common solitary gingival growth thought to arise from the periodontal ligament...
  25. Khoury N, Naffaa L, Shabb N, Haddad M. Juvenile ossifying fibroma: CT and MR findings. Eur Radiol. 2002;12 Suppl 3:S109-13 pubmed
    We describe the CT findings in four patients and the MR imaging in one patient with juvenile ossifying fibroma. Three lesions involved the maxillary sinus and extended to the surrounding structures; one lesion was confined to the ..
  26. Laot A, Zerhouni A, Yapo P, Cottier J, Herbreteau D. [Case No. 4. Ossifying fibroma of the ethmoid]. J Radiol. 2006;87:708-10 pubmed
  27. Cuisia Z, Brannon R. Peripheral ossifying fibroma--a clinical evaluation of 134 pediatric cases. Pediatr Dent. 2001;23:245-8 pubmed
    Reported clinicopathologic studies on the peripheral ossifying fibroma (POF), a reactive gingival lesion, have not addressed the pediatric population in specific detail...
  28. Chindia M, Dimba E, Moshy J, Limo A, Otwoma J, Guthua S. Synchronous occurrence of ossifying fibroma of the mandible and maxilla: a case report. Dent Update. 2008;35:705-7 pubmed
    Although ossifying fibroma (OF) is a slow growing neoplasm, some lesions may behave aggressively, reaching massive proportions that may demand special treatment...
  29. Farquhar T, Maclellan J, Dyment H, Anderson R. Peripheral ossifying fibroma: a case report. J Can Dent Assoc. 2008;74:809-12 pubmed
    This article describes a case of peripheral ossifying fibroma in a 12-year-old girl...
  30. El Mofty S. Psammomatoid and trabecular juvenile ossifying fibroma of the craniofacial skeleton: two distinct clinicopathologic entities. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:296-304 pubmed
    The term juvenile ossifying fibroma is used in the literature in naming 2 microscopically distinct fibro-osseous lesions of the craniofacial skeleton...
  31. Noudel R, Chauvet E, Cahn V, Mérol J, Chays A, Rousseaux P. Transcranial resection of a large sinonasal juvenile psammomatoid ossifying fibroma. Childs Nerv Syst. 2009;25:1115-20 pubmed publisher
    Juvenile psammomatoid ossifying fibroma (JPOF) is a benign but potentially locally aggressive fibroosseous lesion predominantly arising in the paranasal sinuses in children and young adults...
  32. Das U, Azher U. Peripheral ossifying fibroma. J Indian Soc Pedod Prev Dent. 2009;27:49-51 pubmed publisher
    The peripheral ossifying fibroma (POF) is a reactive gingival overgrowth occurring frequently in the anterior maxilla in teenagers and young adults...
  33. Macdonald Jankowski D. Ossifying fibroma: a systematic review. Dentomaxillofac Radiol. 2009;38:495-513 pubmed publisher
    The aim was to evaluate the principal features of ossifying fibroma (OF) by systematic review (SR), and to compare their frequencies among four global groups.
  34. Artico M, Cervoni L, Salvati M, Raco A, Ciappetta P. Ossifying fibroma of the skull: clinical and therapeutic study. Tumori. 1994;80:64-7 pubmed
    b>Ossifying fibroma is a tumor with benign course that rarely affects the cranial bones.
  35. Post G, Kountakis S. Endoscopic resection of large sinonasal ossifying fibroma. Am J Otolaryngol. 2005;26:54-6 pubmed
    ..from one another in their prognosis and treatment, with the most important distinction being that of an ossifying fibroma (OF) and fibrous dysplasia...
  36. Kendi A, Kara S, Altinok D, Keskil S. Sinonasal ossifying fibroma with fluid-fluid levels on MR images. AJNR Am J Neuroradiol. 2003;24:1639-41 pubmed
    b>Ossifying fibroma is a rare benign neoplasm that usually affects mandibular and maxillary bones...
  37. Palacios E. Ossifying fibroma of the ethmoid sinus. Ear Nose Throat J. 2006;85:80 pubmed
  38. Toyosawa S, Yuki M, Kishino M, Ogawa Y, Ueda T, Murakami S, et al. Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. Mod Pathol. 2007;20:389-96 pubmed
    b>Ossifying fibroma and fibrous dysplasia of the jaw are maxillofacial fibro-osseous lesions that should be distinguished each other by a pathologist because they show distinct patterns of disease progression...
  39. Rosenberg A, Mokhtari H, Slootweg P. The natural course of an ossifying fibroma. A case report. Int J Oral Maxillofac Surg. 1999;28:454-6 pubmed
    A patient with an ossifying fibroma in the mandible is presented, with a follow-up period of 38 years. The pathological findings and recommendations for therapy are discussed.
  40. Chang C, Hung H, Chang J, Yu C, Wang Y, Liu B, et al. Central ossifying fibroma: a clinicopathologic study of 28 cases. J Formos Med Assoc. 2008;107:288-94 pubmed publisher
    Central ossifying fibroma (COF) is the most common benign fibro-osseous lesion of the jaw. This retrospective study evaluated the clinical and histopathologic features of 28 COFs in Taiwanese patients.
  41. Vlachou S, Terzakis G, Doundoulakis G, Barbati C, Papazoglou G. Ossifying fibroma of the temporal bone. J Laryngol Otol. 2001;115:654-6 pubmed
    A rare case of ossifying fibroma of the temporal bone is presented. Fibro-osseous lesions are benign neoplasms but may show an aggressive behaviour when invading important anatomical structures...
  42. Brown J, Ijaduola T. Surgery and religiosity. J Natl Med Assoc. 2001;93:109-12 pubmed
    ..We report a case of head and neck tumor with low hemoglobin in which we utilized temporary arterial ligation to aid in minimal blood loss...
  43. Jham B, Durães G, Rocha Santos C. Extensive central ossifying fibroma of the maxilla: a case report with description of an alternative surgical technique. Minerva Stomatol. 2006;55:593-7 pubmed
    Central ossifying fibroma (COF) is a fibrous-osseous lesion containing fibrous tissue and varying amounts of calcified tissue. Although the lesion is preferentially located in the jaws, it may be found elsewhere...
  44. Sovani V, Velagaleti G, Filipowicz E, Gatalica Z, Knisely A. Ossifying fibromyxoid tumor of soft parts: report of a case with novel cytogenetic findings. Cancer Genet Cytogenet. 2001;127:1-6 pubmed
    ..The karyotype was interpreted as 45,XY, der(6;14)(p10;q10),add(12)(q24.3). The chromosomal abnormalities suggest osteochondroblastic rather than neuronal or schwannian lineage...
  45. Bhola M, Gordon S. A lump on the gingiva. J Mich Dent Assoc. 2002;84:28-30 pubmed
  46. Fatima G, Sandesh N, Ravindra S, Kulkarni S. Moving beyond clinical appearance: the need for accurate histological diagnosis. Gen Dent. 2009;57:472-7; quiz 478-9, 535-6 pubmed
    ..The high discrepancy between the clinical and histopathological diagnosis of localized gingival overgrowths indicates the need for a confirmatory histological examination for diagnosis and complete management of the lesion...
  47. Chao M, Donovan T, Sotelo C, Carstens M. In situ osteogenesis of hemimandible with rhBMP-2 in a 9-year-old boy: osteoinduction via stem cell concentration. J Craniofac Surg. 2006;17:405-12 pubmed
  48. Razmyar J, Dezfoulian O, Peighambari S. Ossifying fibroma in a canary (Serinus canaria). J Avian Med Surg. 2008;22:320-2 pubmed
    ..On histopathologic examination, the mass was diagnosed as an ossifying fibroma tumor...
  49. Sarafoleanu C, Manea C, Enache R. [Endoscopic surgery for benign rhino-sinusal tumors]. Chirurgia (Bucur). 2009;104:303-8 pubmed
    ..Evaluation of the efficiency for endoscopical transnasal surgical techniques of rhino-sinusal benign tumors...
  50. Tchane I, Adjibabi W, Biaou O, Alamou S, Balle M, Alao N, et al. [Cemento-ossifing fibroma: two cases]. Rev Stomatol Chir Maxillofac. 2005;106:30-2 pubmed
    Cemento-ossifying fibroma is a rare benign tumor which can affect both jaw bones, particularly the mandible.
  51. Aldred M, Talacko A, Savarirayan R. Jaw lesions and hyperparathyroidism. J Oral Maxillofac Surg. 2004;62:519 pubmed
  52. Erdem L, Erdem C, Gundogdu S. Maxillary sinus ossifying fibroma. JBR-BTR. 2004;87:132-3 pubmed
  53. Zamzam M. Congenital osteofibrous dysplasia of the tibia, associated with pseudoarthrosis of the ipsilateral fibula. Saudi Med J. 2008;29:1507-9 pubmed
    ..The case is a new presentation of congenital osteofibrous dysplasia, and is presented to draw attention to this rare condition that must be considered in the differential diagnosis of congenital lesions of the tibia...