myelolipoma

Summary

Summary: A rare benign tumor of the adrenal gland, several centimeters in diameter, composed in varying proportions of adipose tissue, lymphocytes, and primitive myeloid cells, probably a developmental abnormality. (Dorland, 27th ed)

Top Publications

  1. Akamatsu H, Koseki M, Nakaba H, Sunada S, Ito A, Teramoto S, et al. Giant adrenal myelolipoma: report of a case. Surg Today. 2004;34:283-5 pubmed
    ..We report the case of a giant adrenal myelolipoma in a 51-year old man who presented with a huge abdominal mass and abdominal pain...
  2. Zografos G, Korkolis D, Georgoutsos P, Antypa F, Ageli C, Fragia K, et al. Giant myelolipoma of the right adrenal gland. Int J Clin Pract. 2002;56:319-20 pubmed
    Adrenal myelolipoma is an unusual, benign and hormonally inactive tumour composed of mature adipose and haematopoietic tissue. In the past, these tumours were accidentally discovered at autopsy...
  3. Nguyen B. Retroperitoneal extraadrenal myelolipoma: Technetium-99m sulfur colloid scintigraphy and CT imaging. Clin Nucl Med. 2007;32:135-8 pubmed
  4. Sakaki M, Izaki H, Fukumori T, Taue R, Kishimoto T, Kanayama H. Bilateral adrenal myelolipoma associated with adrenogenital syndrome. Int J Urol. 2006;13:801-2 pubmed
    Adrenal myelolipoma is a rare benign tumor, occasionally reported in association with endocrine disorders...
  5. Mohan K, Gosney J, Holemans J. Symptomatic mediastinal myelolipoma. Respiration. 2006;73:552 pubmed
  6. Cristofaro M, Lazzaro F, Fava M, Aversa C, Musella M. [Giant adrenal myelolipoma: a case report and review of the literature]. Ann Ital Chir. 2004;75:677-81 pubmed
    Adrenal myelolipoma is a rare nonfunctioning tumor consisting histologically of an admixture of adipose tissue and extramedullary hemopoietic elements within the adrenal glands...
  7. Huang W, Zhao S, Lin D. Pulmonary-bronchus myelolipoma and review on extra-adrenal myelolipomas in Chinese literature. Chin Med J (Engl). 2012;125:3188-90 pubmed
    ..Here we describe a new discovered pulmonary-bronchus myelolipoma in a 53-year-old man, which is different from the previously reported ones...
  8. Chang K, Chen P, Huang Z, Lin Y, Kuo P. Adrenal myelolipoma with translocation (3;21)(q25;p11). Cancer Genet Cytogenet. 2002;134:77-80 pubmed
    Adrenal myelolipoma (ML) is a rare, benign, nonfunctioning tumor-like lesion composed of mature adipose tissue interspersed with bone marrow-like hematopoietic elements in various proportions...
  9. Sabate C, Shahian D. Pulmonary myelolipoma. Ann Thorac Surg. 2002;74:573-5 pubmed
    b>Myelolipoma is an extremely rare, benign pulmonary lesion, usually presenting as an asymptomatic pulmonary nodule...

More Information

Publications70

  1. Lu X, Xiao L. Myelolipoma of the lung: a case report. Chin Med J (Engl). 2003;116:951-3 pubmed
  2. Amano T, Takemae K, Niikura S, Kouno M, Amano M. Retroperitoneal hemorrhage due to spontaneous rupture of adrenal myelolipoma. Int J Urol. 1999;6:585-8 pubmed
    A very rare case of retroperitoneal bleeding due to spontaneous rupture of a large adrenal myelolipoma in a 62-year-old woman is reported.
  3. Guo Y, Yang Z, Li Y, Deng Y, Ma E, Min P, et al. Uncommon adrenal masses: CT and MRI features with histopathologic correlation. Eur J Radiol. 2007;62:359-70 pubmed
    ..ganglioneuroblastoma, extramedullary plasmacytoma (EMP), neurilemmoma, and lymphoma), fat-containing masses (myelolipoma, teratoma), and infectious masses (tuberculoma), and the imaging features of these uncommon masses are ..
  4. Pascual Garcia X, Bujons Tur A, Rodriguez Faba O, Gómez Ruiz J, Palou Redorta J, Villavicencio Mavrich H. [Extraadrenal perirenal myelolipoma: report of a case and review of the literature]. Actas Urol Esp. 2007;31:932-4 pubmed
    ..These lesions are usually asyntomatic and often found incidentally on radiographic studies. We report a case of extra-adrenal perirenal myelolipoma.
  5. Timonera E, Paiva M, Lopes J, Eloy C, Van der Kwast T, Asa S. Composite adenomatoid tumor and myelolipoma of adrenal gland: report of 2 cases. Arch Pathol Lab Med. 2008;132:265-7 pubmed publisher
    Adenomatoid tumor and myelolipoma are benign, hormonally inactive tumors that are often incidental findings in the adrenal glands...
  6. Hagiwara H, Usui T, Kimura T, Tagami T, Naruse M, Minamiguchi S, et al. Lack of ACTH and androgen receptor expression in a giant adrenal myelolipoma associated with 21-hydroxylase deficiency. Endocr Pathol. 2008;19:122-7 pubmed publisher
    ..To clarify the role of ACTH and androgen in the pathogenesis of myelolipoma, we report a case of giant adrenal myelolipoma in a patient with poorly controlled congenital adrenal ..
  7. Sagan D, Zdunek M, Korobowicz E. Primary myelolipoma of the chest wall. Ann Thorac Surg. 2009;88:e39-41 pubmed publisher
    b>Myelolipoma is a rare neoplasm composed of an admixture of mature adipose tissue and hematopoietic elements. It typically occurs in adrenal glands as a solitary, well-circumscribed mass, and the thoracic location is extremely unusual...
  8. Fernandes G, Gupta R, Kandalkar B. Giant adrenal myelolipoma. Indian J Pathol Microbiol. 2010;53:325-6 pubmed publisher
    Adrenal myelolipoma is a rare benign tumor composed of adipose and hematopoietic tissue. Most tumors are small in size and incidentally detected...
  9. Dan D, Bahadursingh S, Hariharan S, Ramjit C, Naraynsingh V, Maharaj R. Extra-adrenal perirenal myelolipoma. A case report and review of literature. G Chir. 2012;33:62-5 pubmed
    ..We present a rare case of perirenal extra-adrenal myelolipoma and we review the imaging characteristics and management options for this condition.
  10. Ersoy E, Ozdogan M, Demirag A, Aktimur R, Kulacoglu H, Kulacoglu S, et al. Giant adrenal myelolipoma associated with small bowel leiomyosarcoma: a case report. Turk J Gastroenterol. 2006;17:126-9 pubmed
    Adrenal myelolipoma is a rare, benign and biochemically inactive tumor...
  11. Sawhney R, McRae B, Lazarchick J. A rare case of a multifocal extra-adrenal myelolipoma with markedly hypocellular bone marrow. Ann Clin Lab Sci. 2006;36:208-11 pubmed
    ..To our knowledge, this is the first case report of a markedly abnormal marrow examination in a patient with extra-adrenal myelolipoma, and implicates the extra-osseous masses as the driving force behind his normal hematopoesis.
  12. Talwalkar S, Shaheen S. Extra-adrenal myelolipoma in the renal hilum: a case report and review of the literature. Arch Pathol Lab Med. 2006;130:1049-52 pubmed
    b>Myelolipoma most commonly arises in the adrenal gland. Extra-adrenal myelolipomas are rare; to our knowledge, approximately 37 previous cases have been reported...
  13. Répássy D, Csata S, Sterlik G, Ivanyi A. Giant adrenal myelolipoma. Pathol Oncol Res. 2001;7:72-3 pubmed
    Authors present a case of giant adrenal myelolipoma, where the tumor was hormonally inactive but caused abdominal and flank pain. The huge tumor, a 20x18x10 cm mass, was surgically removed. The ipsilateral kidney was preserved.
  14. Meyer A, Behrend M. Presentation and therapy of myelolipoma. Int J Urol. 2005;12:239-43 pubmed
    Adrenal myelolipoma is a rare and benign, hormonally inactive tumor frequently discovered incidentally...
  15. Arzanian M, KhaleghNejad Tabari A, Shamsian B, Jadali F, Gharib A, Esfahani H. Generalized myelolipoma. Arch Iran Med. 2006;9:274-6 pubmed
    b>Myelolipoma is a benign tumor originating from hematopoietic and adipose tissue...
  16. Umpierrez M, Fackler S, Umpierrez G, Rubin J. Adrenal myelolipoma associated with endocrine dysfunction: review of the literature. Am J Med Sci. 1997;314:338-41 pubmed
    A case of bilateral adrenal myelolipoma in association with congenital adrenal hyperplasia caused by 21-hydroxylase deficiency is presented...
  17. Ueno H, Miyake T, Kobayashi Y, Yamada K, Uzuka Y. Epidural spinal myelolipoma in a dog. J Am Anim Hosp Assoc. 2007;43:132-5 pubmed
    Epidural spinal myelolipoma was diagnosed in a 13-year-old, male Siberian husky that was referred for evaluation of progressive pelvic limb paresis and urinary incontinence...
  18. Sato K, Ueda Y, Katsuda S, Tsuchihara K. Myelolipoma of the lung: a case report and brief review. J Clin Pathol. 2007;60:728-30 pubmed
  19. Patel V, Babalola O, Fortson J, Weaver W. Adrenal myelolipoma: report of a case and review of the literature. Am Surg. 2006;72:649-54 pubmed
    Adrenal myelolipoma is a rare benign tumor composed of mature lipomatous and hemopoietic tissue...
  20. Adams S, Liermann D, Mruck S. Functional and morphological imaging of extraadrenal myelolipoma. Clin Nucl Med. 2009;34:226-9 pubmed publisher
    b>Myelolipoma is a rare, hormonally inactive, benign tumor consisting of fat and hematopoietic cells. It is often encountered in the adrenal gland. Less frequently, it may occur in extraadrenal sites...
  21. Vaziri M, Sadeghipour A, Pazooki A, Shoolami L. Primary mediastinal myelolipoma. Ann Thorac Surg. 2008;85:1805-6 pubmed publisher
    b>Myelolipoma is a rare mesenchymal tumor composed of an admixture of fat and bone marrow-derived hematopoietic cells. It is typically an adrenal lesion, and mediastinal location is extremely unusual...
  22. Wagnerova H, Lazurova I, Bober J, Sokol L, Zachar M. Adrenal myelolipoma. 6 cases and a review of the literature. Neoplasma. 2004;51:300-5 pubmed
    Adrenal myelolipoma is an uncommon, benign and hormonally inactive tumor. Most lesions are asymptomatic and usually are discovered incidentally at autopsy studies...
  23. Hisamatsu H, Sakai H, Tsuda S, Shigematsu K, Kanetake H. Combined adrenal adenoma and myelolipoma in a patient with Cushing's syndrome: case report and review of the literature. Int J Urol. 2004;11:416-8 pubmed
    b>Myelolipoma is an uncommon benign tumor of unknown etiology and adrenal myelolipoma is rarely associated with endocrine disorders...
  24. Porter B, Goens S, Brasky K, Hubbard G. A case report of hepatocellular carcinoma and focal nodular hyperplasia with a myelolipoma in two chimpanzees and a review of spontaneous hepatobiliary tumors in non-human primates. J Med Primatol. 2004;33:38-47 pubmed
    ..Here we report a case of hepatic carcinoma and a case of hepatic focal nodular hyperplasia (FNH) and myelolipoma in two captive chimpanzees...
  25. Zieker D, Königsrainer I, Miller S, Vogel U, Sotlar K, Steurer W, et al. Simultaneous adrenal and extra-adrenal myelolipoma - an uncommon incident: case report and review of the literature. World J Surg Oncol. 2008;6:72 pubmed publisher
    ..Other soft tissue tumours such as well-differentiated liposarcomas appear morphological almost identical. Preoperative imaging and especially biopsy are important tools to diagnose these lesions...
  26. Porcaro A, Novella G, Ficarra V, Cavalleri S, Antoniolli S, Curti P. Incidentally discovered adrenal myelolipoma. Report on 3 operated patients and update of the literature. Arch Ital Urol Androl. 2002;74:146-51 pubmed
    ..The aim of this study was to find out the clinical outcome of 3 patients operated for incidentally discovered adrenal myelolipoma as well as to update the literature concerning this topic.
  27. Dell Avanzato R, Castaldi F, Giovannini C, Mercadante E, Cianciulli P, Carlini M. Giant symptomatic myelolipoma of the right adrenal gland: a case report. Chir Ital. 2009;61:231-6 pubmed
    Adrenal myelolipoma is an uncommon tumour of the adrenal gland, usually unilateral, frequently associated with hypertension and obesity, with a benign biological behaviour and without hormonal activity, first described in 1905...
  28. Olobatuyi F, MacLennan G. Myelolipoma. J Urol. 2006;176:1188 pubmed
  29. Morandi F, Mays J, Newman S, Adams W. Imaging diagnosis--bilateral adrenal adenomas and myelolipomas in a dog. Vet Radiol Ultrasound. 2007;48:246-9 pubmed
  30. Al Brahim N, Asa S. Myelolipoma with adrenocortical adenoma: an unusual combination that can resemble carcinoma. Endocr Pathol. 2007;18:103-5 pubmed
    b>Myelolipoma is a benign tumor that occurs in the adrenal gland and rarely in extra-adrenal sites. Commonly, it is diagnosed as an incidental finding...
  31. Ide H, Terado Y, Nakagawa T, Saito K, Kamiyama Y, Muto S, et al. Incidentally discovered adrenal myelolipoma associated with hyperthyroidism. Int J Clin Oncol. 2007;12:379-81 pubmed
    ..We report a case of adrenal myelolipoma in a patient with hyperthyroidism; this benign tumor expressed both thyroid hormone receptor alpha and beta.
  32. Singla A, Kechejian G, Lopez M. Giant presacral myelolipoma. Am Surg. 2003;69:334-8 pubmed
    ..Particular radiographic and histologic qualities distinguish this tumor from invasive malignancy. A case report is presented with a review of the literature on extra-adrenal myelolipomas...
  33. Gao B, Sugimura H, Sugimura S, Hattori Y, Iriyama T, Kano H. Mediastinal myelolipoma. Asian Cardiovasc Thorac Ann. 2002;10:189-90 pubmed
    b>Myelolipoma is a rare tumor, and a mediastinal location is extremely unusual. The main pathologic feature is the coexistence of mature adipose tissue and bone marrow cells; the presence of megakaryocytes is essential for diagnosis...
  34. Amendolara M, Barbarino C, Bucca D, Guarnieri F, Novello G, Romano F, et al. [Giant and bilateral adrenal myelolipoma. Case report]. G Chir. 2008;29:85-8 pubmed
    The adrenal myelolipoma is a relatively rare benign tumour of adipose cell and bone marrow elements, non functioning and asymptomatic. Giant and bilateral adrenal myelolipoma is quite rare...
  35. Zhang X, Lu B. Ovarian steroid cell tumor, not otherwise specified (NOS): an unusual case with myelolipoma. Int J Gynecol Pathol. 2011;30:460-5 pubmed publisher
    b>Myelolipoma is an uncommon lesion composed of mature fat and hematopoietic cells. Extra-adrenal myelolipoma is rare. We report an unusual case of concurrent myelolipoma in a steroid cell tumor in a 21-year-old woman with virilization...
  36. Chakraborty J, Paul P, Gumta M, Ghosh G, Goswami B. Adrenal myelolipoma--report of a case. J Indian Med Assoc. 2006;104:148-9 pubmed
    Adrenal myelolipoma is a rare, benign, non-secreting tumour composed of adipose and haematopoietic tissue. One such rare case in a 32-year-old female who presented with'pain in right lumbar region is reported here...
  37. Huang W, Zhao Y, Yin X, Qi Q. Primary myelolipoma of the lung: a case of report and review of literature. Pol J Pathol. 2012;63:204-6 pubmed
    b>Myelolipoma of the lung is a rare benign tumor composed of mature adipose tissue and normal hematopoietic cells. Only 8 cases of primary myelolipoma of the lung have been reported up to date...
  38. Cobanoglu U, Yaris N, Cay A. Adrenal myelolipoma in a child. Pediatr Surg Int. 2005;21:500-2 pubmed
    A case of adrenal myelolipoma is reported in a 14-year-old girl...
  39. Nakajo M, Onohara S, Shinmura K, Fujiyoshi F, Nakajo M. Embolization for spontaneous retroperitoneal hemorrhage from adrenal myelolipoma. Radiat Med. 2003;21:214-9 pubmed
    Adrenal myelolipoma is a benign tumor composed of fat and bone marrow tissues and is usually found incidentally. Spontaneous retroperitoneal hemorrhage from this tumor is rare...
  40. Jung S, Kim S, Kang T, Kwon D, Park K, Ryu S. Bilateral adrenal myelolipoma associated with hyperaldosteronism: report of a case and review of the literature. Urology. 2007;70:1223.e11-3 pubmed
    Adrenal myelolipoma is a rare benign tumor composed of mature adipose cells and hematopoietic elements. Although they are not hormonally active, there is very rarely an association with functional adrenal disorders...
  41. Lawler L, Pickhardt P. Giant adrenal myelolipoma presenting with spontaneous hemorrhage. CT, MR and pathology correlation. Ir Med J. 2001;94:231-3 pubmed
    We report a case of a 56-year old symptomatic patient found to have a giant adrenal myelolipoma with hemorrhage. The characteristic CT and MR features and their aid in the diagnosis are demonstrated...
  42. Franiel T, Fleischer B, Raab B, Fuzesi L. Bilateral thoracic extraadrenal myelolipoma. Eur J Cardiothorac Surg. 2004;26:1220-2 pubmed
    b>Myelolipoma commonly occurs in the adrenal gland and is composed of both adipose tissue and normal hematopoietic elements...
  43. Mermejo L, Elias Junior J, Saggioro F, Tucci Junior S, Castro M, Moreira A, et al. Giant adrenal myelolipoma associated with 21-hydroxylase deficiency: unusual association mimicking an androgen-secreting adrenocortical carcinoma. Arq Bras Endocrinol Metabol. 2010;54:419-24 pubmed
    The objective of this study was to describe a case of giant myelolipoma associated with undiagnosed congenital adrenal hyperplasia (CAH) due to 21-hydroxylase (21OH) deficiency...
  44. Lu H, Gan M, Chen H, Huang S. Adrenal myelolipoma within myxoid cortical adenoma associated with Conn's syndrome. J Zhejiang Univ Sci B. 2008;9:500-5 pubmed publisher
    The coexistence of myelolipoma within adrenal cortical adenoma is extremely rare, for both tumors present usually as separate entities. There are only 16 such cases reported worldwide...
  45. Hagspiel K. Manifestation of Hodgkin's lymphoma in an adrenal myelolipoma. Eur Radiol. 2005;15:1757-9 pubmed
    ..The computed tomography findings of Hodgkin's lymphoma manifested in an adrenal myelolipoma are described. This collision tumor constellation has not been reported previously.
  46. Goel S, Aeron R, Goel A, Singhai A. Retroperitoneal teratoma simulating giant adrenal myelolipoma: a diagnostic puzzle. BMJ Case Rep. 2017;2017: pubmed publisher
    ..After radiological investigations, she was diagnosed as case of adrenal myelolipoma which on excision turned out histologically to be retroperitoneal teratoma...
  47. Gallo M, Mineur L, Emptas H, Costes V, Ramos J. [Hepatic myelolipoma: A rare entity, case report and review of the literature]. Ann Pathol. 2017;37:415-419 pubmed publisher
    Hepatic myelolipoma is a rare entity with only 17 cases described in the literature. A 73mm right liver mass was fortuitously discovered in a 55-year-old man...
  48. Cives M, Ciavarella S, Dammacco F, Silvestris F. Cell fusion in myeloma marrow microenvironment: role in tumor progression. Crit Rev Oncog. 2013;18:75-95 pubmed
  49. Civrilli K, Damry N, Steppé R, Efira A, Mathieu J. Bilateral adrenal myelolipomas. JBR-BTR. 2008;91:90-1 pubmed
  50. Ong K, Tan K, Putti T. Myelolipoma within a non-functional adrenal cortical adenoma. Singapore Med J. 2007;48:e200-2 pubmed
    b>Myelolipoma within an adrenal cortical adenoma is a very rare cause of adrenal incidentaloma, and only nine cases have been reported in the English and Japanese literature...
  51. Merchant S, Herman C, Amin M, Ro J, Troncoso P. Myelolipoma associated with adrenal ganglioneuroma. Arch Pathol Lab Med. 2002;126:736-7 pubmed
    ..We report an unusual case of myelolipoma associated with ganglioneuroma of the adrenal medulla. The histogenesis of myelolipoma remains speculative...
  52. Udupa S, Usha M, Visweswara R, Desai M. Left-sided giant adrenal myelolipoma secreting catecholamine. Indian J Pathol Microbiol. 2012;55:389-91 pubmed publisher
    Adrenal myelolipoma (AML) is a rare benign tumor composed of mature adipose and hematopoietic tissue. Most of these patients are asymptomatic and the tumors are non-secreting...
  53. Courcoutsakis N, Patronas N, Cassarino D, Griffin K, Keil M, Ross J, et al. Hypodense nodularity on computed tomography: novel imaging and pathology of micronodular adrenocortical hyperplasia associated with myelolipomatous changes. J Clin Endocrinol Metab. 2004;89:3737-8 pubmed
  54. Gong Y, Sun X. Fine-needle aspiration of a presacral myelolipoma. Diagn Cytopathol. 2006;34:29-30 pubmed
  55. Allison K, Mann G, Norwood T, Rubin B. An unusual case of multiple giant myelolipomas: clinical and pathogenetic implications. Endocr Pathol. 2003;14:93-100 pubmed
    ..We report a case of three giant adrenal myelolipomas arising in a persistently virilized female with congenital adrenal hyperplasia, supporting a role for hormonal stimuli in myelolipoma formation.
  56. Adachi S, Kawamura N, Hatano K, Kakuta Y, Takada T, Hara T, et al. Lipomatous ganglioneuroma of the retroperitoneum. Pathol Int. 2008;58:183-6 pubmed publisher
    ..Because of the fat element, CT and magnetic resonance imaging suggested myelolipoma inside or outside the right adrenal gland...
  57. Ahsan T, Kanwal S, Banu Z, Jabeen R. Virilization with adrenal myelolipoma, adrenal hyperplasia, and fibroadenoma of breast. J Coll Physicians Surg Pak. 2010;20:819-21 pubmed publisher
    Adrenal myelolipoma is a rare, benign and usually hormonally inactive tumour. We report a case of a young female who presented with hormonally active tumour causing virilization and associated type-2 Diabetes mellitus...
  58. Mahe E, El Shinnawy I. A "tumour trifecta:" myelolipomata arising within an adrenocortical adenoma ipsilateral to a synchronous clear cell renal cell carcinoma. Malays J Pathol. 2010;32:123-8 pubmed
    ..In particular, we emphasize the epidemiological, histological and immunohistochemical features that are helpful in determining the origin and malignant potential of adrenal lesions...
  59. Atalabi O, Ogunseyinde A. A case of adrenal myelolipoma mimicking pheocromocytoma. Afr J Med Med Sci. 2001;30:139-41 pubmed
    ..mass, which was initially diagnosed as phaeochromocytoma was excised and was found at histology to be myelolipoma! The radiological investigations and appearances (compared with phaeochromocytoma where necessary) have been ..
  60. Dann P, Krinsky G, Israel G. Case 135: presacral myelolipoma. Radiology. 2008;248:314-6 pubmed publisher
  61. Gamss C, Chia F, Chernyak V, Rozenblit A. Giant hemorrhagic myelolipoma in a patient with sickle cell disease. Emerg Radiol. 2009;16:319-22 pubmed publisher
    Adrenal myelolipoma is a rare, benign tumor consisting of adipose tissue and hematopoetic elements...