connective and soft tissue neoplasms

Summary

Summary: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.

Top Publications

  1. Matsumine A, Shintani K, Kusuzaki K, Matsubara T, Satonaka H, Wakabayashi T, et al. Expression of decorin, a small leucine-rich proteoglycan, as a prognostic factor in soft tissue tumors. J Surg Oncol. 2007;96:411-8 pubmed
    ..However, there have so far been no reports describing the clinicopathological implications of decorin in soft tissue tumors. The aim of this study was to examine whether decorin expression is a prognostic factor in soft tissue tumors...
  2. Goh B, Chow P, Kesavan S, Yap W, Wong W. Outcome after surgical treatment of suspected gastrointestinal stromal tumors involving the duodenum: is limited resection appropriate?. J Surg Oncol. 2008;97:388-91 pubmed publisher
  3. Raimbeau G. [Recurrent carpal tunnel syndrome]. Chir Main. 2008;27:134-45 pubmed publisher
    ..These findings indicate that the first intervention must be performed with the most rigorous attention to technical detail...
  4. Menendez C, Gil Ugarteburu R, Capilla Ampudia J, Corte Torres G, Fuente E, Argüelles M. A case of pararenal PEComa with extensive bone metaplasia. Virchows Arch. 2008;452:349-50 pubmed publisher
  5. Teh J, Whiteley G. MRI of soft tissue masses of the hand and wrist. Br J Radiol. 2007;80:47-63 pubmed
  6. Suehara Y. [Proteomic analysis for connective and soft tissue neoplasms]. Gan To Kagaku Ryoho. 2008;35:407-410 pubmed
  7. Laskin W, Fetsch J, Miettinen M. Nuchal fibrocartilaginous pseudotumor: a clinicopathologic study of five cases and review of the literature. Mod Pathol. 1999;12:663-8 pubmed
    ..The nuchal fibrocartilaginous pseudotumor is a benign lesion caused by fibrocartilaginous metaplasia of the lower portion of the nuchal ligament, probably as a result of localized trauma or chronic mechanical stress...
  8. Adachi Y, Horie Y, Kitamura Y, Nakamura H, Taniguchi Y, Miwa K, et al. CD1a expression in PEComas. Pathol Int. 2008;58:169-73 pubmed publisher
    ..The present study confirms CD1a expression in many cases of PEComa. These data suggest that CD1a expression can be an additional new marker for PEComas and also supports the distinct and integrated disease entity of PEComas...
  9. Rizzello G, Franceschi F, Meloni M, Cristi E, Barnaba S, Rabitti C, et al. Para-articular osteochondroma of the knee. Arthroscopy. 2007;23:910.e1-4 pubmed
    ..Patients with these lesions are currently treated with the use of marginal resection or excision...

More Information

Publications53

  1. Wu C, Wei Q, Utomo V, Nadesan P, Whetstone H, Kandel R, et al. Side population cells isolated from mesenchymal neoplasms have tumor initiating potential. Cancer Res. 2007;67:8216-22 pubmed
    ..In addition, our data suggest that the proportion of SP cells could be used as a prognostic factor and that therapeutically targeting this subpopulation of cells could be used to improve patient outcome...
  2. Hornick J, Fletcher C. Sclerosing PEComa: clinicopathologic analysis of a distinctive variant with a predilection for the retroperitoneum. Am J Surg Pathol. 2008;32:493-501 pubmed publisher
    ..Sclerosing PEComas seem to pursue an indolent clinical course, unless associated with a frankly malignant component. Long-term follow-up will be required to confirm these findings...
  3. Ranchere Vince D. [Soft tissue pathology: current issues and perspectives]. Ann Pathol. 2003;23:109-13 pubmed
  4. Schraith D, Hahm G, Niemann T, DeYoung B. Alpha-inhibin immunoreactivity in soft-tissue neoplasia. Mod Pathol. 2003;16:1205-9 pubmed
    ..However, the rarity of alpha-inhibin expression by soft-tissue neoplasms provides further support for its overall specificity as a marker of adrenal cortical differentiation in the biopsy evaluation of a retroperitoneal mass...
  5. Ng T, Gown A, Barry T, Cheang M, Chan A, Turbin D, et al. Nuclear beta-catenin in mesenchymal tumors. Mod Pathol. 2005;18:68-74 pubmed
    ..High-level nuclear beta-catenin staining serves as a useful diagnostic tool, as it is specific to a small subset of mesenchymal tumors...
  6. Tregnaghi A, Dal Bosco C, Talenti E, Borsato S, Rossi C, Lumachi F, et al. Usefulness and limits of ultrasound-guided hook-wire positioning for localisation of soft tissue lesions prior to surgery. Radiol Med. 2005;110:646-54 pubmed
    ..The aim of our study was to assess the usefulness of positioning metal wires under ultrasound guidance for localising soft tissue lesions in the preoperative phase...
  7. Bisceglia M, Fisher C, Suster S, Kazakov D, Cooper K, Michal M. Tumoral, quasitumoral and pseudotumoral lesions of the superficial and somatic soft tissue: new entities and new variants of old entities recorded during the last 25 years. Part IV: excerpta II. Pathologica. 2004;96:436-63 pubmed
  8. Park E, Hong S, Choi J, Lee M, Kang H. Glomangiomatosis: magnetic resonance imaging findings in three cases. Skeletal Radiol. 2005;34:108-11 pubmed
    ..We report on three cases of glomangiomatosis in the foot, and describe their MR findings and review previous case reports on this subject...
  9. Bhardwaj A, Frankel W, Pellegata N, Wen P, Prasad M. Intracellular versican expression in mesenchymal spindle cell tumors contrasts with extracellular expression in epithelial and other tumors--a tissue microarray-based study. Appl Immunohistochem Mol Morphol. 2008;16:263-6 pubmed publisher
  10. Gonzalez Campora R. Cytoarchitectural findings in the diagnosis of primary soft tissue tumors. Acta Cytol. 2001;45:115-46 pubmed
    ..To review the major cytologic and architectural criteria in the diagnosis of primary soft tissue tumors, highlighting the importance of clinical correlation and the value of ancillary methods...
  11. Spitsbergen J, Tsai H, Reddy A, Miller T, Arbogast D, Hendricks J, et al. Neoplasia in zebrafish (Danio rerio) treated with N-methyl-N'-nitro-N-nitrosoguanidine by three exposure routes at different developmental stages. Toxicol Pathol. 2000;28:716-25 pubmed
    ..The zebrafish is a responsive, cost-effective lower vertebrate model system in which to study mechanisms of carcinogenesis...
  12. Kim E, Choe Y, Sung K, Park S, Kim J, Ko Y. Multidetector CT and MR imaging of cardiac tumors. Korean J Radiol. 2009;10:164-75 pubmed publisher
    ..Presurgical assessment of malignant cardiac tumors with the use of MDCT and MRI may allow determination of the resectability of tumors and planning for the reconstruction of cardiac chambers...
  13. Genevay M, Coindre J, Guillou L. [Recent entities in soft tissue tumor pathology. Part 2]. Ann Pathol. 2003;23:135-48 pubmed
    ..The role of immunohistochemistry and molecular pathology in the identification and delineation of these new entities is emphasized...
  14. Zamecnik M, Michal M. Nuchal fibrocartilaginous pseudotumor: immunohistochemical and ultrastructural study of two cases. Pathol Int. 2001;51:723-8 pubmed
    ..Ultrastructurally, cells with features of fibroblasts and chondroblasts without any signs of myofibroblastic or myochondroblastic differentiation were found...
  15. Dow N, Giblen G, Sobin L, Miettinen M. Gastrointestinal stromal tumors: differential diagnosis. Semin Diagn Pathol. 2006;23:111-9 pubmed
    ..To comprehensively capture all GISTs, KIT immunostains should be performed on all unclassified epithelioid and mesenchymal tumors of the abdomen. This is a US government work. There are no restrictions on its use...
  16. Martignoni G, Pea M, Reghellin D, Zamboni G, Bonetti F. Perivascular epithelioid cell tumor (PEComa) in the genitourinary tract. Adv Anat Pathol. 2007;14:36-41 pubmed
    ..PEComas have been described in different organs and are considered ubiquitous tumors. In this review we discuss recent informations related to PEComas in the genitourinary tract...
  17. Matsumine A, Kusuzaki K, Matsubara T, Nakamura T, Uchida A. [Topic of minimally invasive surgery for connective and soft tissue neoplasms]. Gan To Kagaku Ryoho. 2008;35:420-423 pubmed
  18. Baysefer A, Akay K, Izci Y, Kayali H, Timurkaynak E. The clinical and surgical aspects of spinal tumors in children. Pediatr Neurol. 2004;31:261-6 pubmed
    ..Laminotomy was the main surgical method in 60% of the patients with spinal tumor, especially in children younger than 3 years of age...
  19. Henderson S, Guiliano D, Presneau N, McLean S, Frow R, Vujovic S, et al. A molecular map of mesenchymal tumors. Genome Biol. 2005;6:R76 pubmed
    ..Histological diagnosis is challenging due to the poor or heterogenous differentiation of many tumors, resulting in uncertainty over prognosis and appropriate therapy...
  20. Calder K, Schlauder S, Morgan M. Malignant perivascular epithelioid cell tumor ('PEComa'): a case report and literature review of cutaneous/subcutaneous presentations. J Cutan Pathol. 2008;35:499-503 pubmed
  21. Lewandowski A, Markocka Maczka K, Taboła R. [Non-epithelial tumors of the large intestine]. Wiad Lek. 2008;61:227-31 pubmed
    ..Clinical course and intraoperative situation were decisive as to type of surgery. Although mesenchymal tumors are very rare among large intestine neoplasms, one should consider their occurrence while carrying preoperative diagnosis...
  22. Nakatani F. [Molecular targeting for treatment of connective and soft tissue neoplasms]. Gan To Kagaku Ryoho. 2008;35:411-414 pubmed
  23. Spitsbergen J, Tsai H, Reddy A, Miller T, Arbogast D, Hendricks J, et al. Neoplasia in zebrafish (Danio rerio) treated with 7,12-dimethylbenz[a]anthracene by two exposure routes at different developmental stages. Toxicol Pathol. 2000;28:705-15 pubmed
    ..Thus, zebrafish are a valuable model system in which to study mechanistic aspects of the carcinogenesis process...
  24. Steigen S, Schaeffer D, West R, Nielsen T. Expression of insulin-like growth factor 2 in mesenchymal neoplasms. Mod Pathol. 2009;22:914-21 pubmed publisher
    ..IGF2 protein expression among mesenchymal tumors is largely consistent with gene expression studies and suggests a potential for molecular therapy targeting the IGF signaling pathway system in these neoplasms...
  25. Mechtersheimer G, Lehnert T, Penzel R, Joos S, Egerer G, Otto H. [Gastrointestinal stromal tumors. A morphologic and molecular genetic independent tumor entity with new therapeutic perspectives]. Pathologe. 2003;24:182-91 pubmed
    ..First therapeutic applications of imatinib in patients with progressive GISTs have yielded promising results. This review focuses on the morphological and molecular findings in GISTs which have opened up a new therapeutic perspective...
  26. Tsukushi S, Takahashi M, Miyagi N, Matsushima S, Andoh M, Kinosada Y. Magnetization transfer ratios of musculoskeletal tumors. J Orthop Sci. 2002;7:524-7 pubmed
    ..The DNA index correlated with MTR in such musculoskeletal tumors ( P < 0.05). This suggests that MTR can be used as a parameter to quantitatively indicate malignancy...
  27. Cheung F, Ma L, Wu W, Siu T, Choi P, Tai Y. Oncogenic osteomalacia associated with an occult phosphaturic mesenchymal tumour: clinico-radiologico-pathological correlation and ultrastructural studies. Hong Kong Med J. 2006;12:319-21 pubmed
    ..Clinico-radiologico-pathological correlation and ultrastructural studies of the tumour threw light on the pathogenesis and pathophysiology of this rare disease...
  28. Lee H, Han S, Kang J, Lee M, Choi J, Moon K, et al. Multiple mucinous and lipomatous variant of eccrine angiomatous hamartoma associated with spindle cell hemangioma: a novel collision tumor?. J Cutan Pathol. 2006;33:323-6 pubmed
    ..To our knowledge, the co-existence of EAH with SCH is a novel finding and not yet described...
  29. van de Rijn M, Rubin B. Gene expression studies on soft tissue tumors. Am J Pathol. 2002;161:1531-4 pubmed
  30. Kirsch R, Gao Z, Riddell R. Gastrointestinal stromal tumors: diagnostic challenges and practical approach to differential diagnosis. Adv Anat Pathol. 2007;14:261-85 pubmed
  31. Kenerson H, Folpe A, Takayama T, Yeung R. Activation of the mTOR pathway in sporadic angiomyolipomas and other perivascular epithelioid cell neoplasms. Hum Pathol. 2007;38:1361-71 pubmed
    ..This suggests the possibility that mTOR inhibitors such as rapamycin may be therapeutic for this class of disease...
  32. Wang X, Ding X, Zhang L, Zhang H, Liu N, Zhang R, et al. [Correlation analysis of gastric cancer with extranodal metastasis]. Zhonghua Wei Chang Wai Ke Za Zhi. 2007;10:436-9 pubmed
    ..To evaluate the correlations between extranodal metastasis(EM)and clinicopathologic features of gastric cancer and the relationship between EM and prognosis of gastric cancer...
  33. Lee K, Song K, Kwon Y, Lee I, Lee J, Lim T. Mesenchymal tumours of the thorax: CT findings and pathological features. Clin Radiol. 2003;58:934-44 pubmed
    ..Mesenchymal tumours tend to show protean and non-specific imaging characteristics. However, in some instances, the imaging characteristics of the tumour may allow a specific diagnosis to be made, such as with lipoid or vascular tumours...
  34. Policarpio Nicolas M, Covell J, Bregman S, Atkins K. Fine needle aspiration cytology of clear cell "sugar" tumor (PEComa) of the lung: report of a case. Diagn Cytopathol. 2008;36:89-93 pubmed publisher
    ..The differential diagnosis and methods for distinguishing the various clear cells lesions in the lung are discussed...
  35. Hoey E, Mankad K, Puppala S, Gopalan D, Sivananthan M. MRI and CT appearances of cardiac tumours in adults. Clin Radiol. 2009;64:1214-30 pubmed publisher
    ..This paper reviews the MRI and CT features of primary and secondary cardiac malignancy. Important differential considerations and potential diagnostic pitfalls are also highlighted...
  36. Policarpio Nicolas M, Abbott T, Dalkin A, Bennett Wick J, Frierson H. Phosphaturic mesenchymal tumor diagnosed by fine-needle aspiration and core biopsy: a case report and review of literature. Diagn Cytopathol. 2008;36:115-9 pubmed publisher
    ..The bland-appearing cytologic features of a spindle cell tumor in a patient with osteomalacia should suggest the diagnosis of PMT...
  37. Cho K, Ro J, Choi J, Choi S, Nam S, Kim S. Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases. Eur Arch Otorhinolaryngol. 2008;265 Suppl 1:S47-56 pubmed
    ..Awareness of the development of various mesenchymal tumors in the major salivary glands could increase the accuracy of preoperative and postoperative diagnosis, and therapeutic efficacy...
  38. Zubović A, Cavanagh M, Hurson B. Value of measuring subpopulations of T and B lymphocytes in patients with musculoskeletal tumours. Arch Orthop Trauma Surg. 2008;128:921-9 pubmed
    ..Aims of our study were to assess the clinical value of measuring subpopulations of T and B lymphocytes in patients with musculoskeletal tumours as an immunodiagnostic procedure in the primary diagnosis of tumours...
  39. Suehiro Y, Tachikawa Y, Abe Y, Ohshima K, Muta K, Tani K. Epithelioid hemangioendothelioma presenting with severe myelofibrosis and a high serum hyaluronan level. Eur J Haematol. 2007;79:349-53 pubmed
    ..To the best of our knowledge, this is the first report of MF occurring in an EHE; hyaluronan may have played an important role in the pathogenesis of fibrosis in this case...
  40. Folpe A, Mentzel T, Lehr H, Fisher C, Balzer B, Weiss S. Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature. Am J Surg Pathol. 2005;29:1558-75 pubmed
    ..PEComas with two or more worrisome histologic features should be considered malignant. Occasional PEComas express unusual markers, such as S-100 protein, desmin, and rarely CK. The role of TFE3 in PEComas should be further studied...
  41. Lasota J, Fanburg Smith J. Genetics for the diagnosis and treatment of mesenchymal tumors. Semin Musculoskelet Radiol. 2007;11:215-30 pubmed publisher
    ..Cytogenetic and molecular genetic alterations identified in various mesenchymal tumors are often valuable for diagnosis, prognosis, and treatment strategies...
  42. Weinreb I, Howarth D, Latta E, Ghazarian D, Chetty R. Perivascular epithelioid cell neoplasms (PEComas): four malignant cases expanding the histopathological spectrum and a description of a unique finding. Virchows Arch. 2007;450:463-70 pubmed
    ..These tumours may manifest largely as sarcomas appearing to be undifferentiated and should be considered in their differential diagnosis...
  43. Lemke A, Senfft von Pilsach M, Lubbe A, Bergemann C, Riess H, Felix R. MRI after magnetic drug targeting in patients with advanced solid malignant tumors. Eur Radiol. 2004;14:1949-55 pubmed
    ..MRI is a suitable method to detect magnetite particles, deposited at the tumor site via magnetic drug targeting. MRI is therefore eligible to control the success of MDT and to assess the tumor size after the end of therapy...
  44. Hendryk S, Czecior E, Misiołek M, Namysłowski G, Mrowka R. Surgical strategies in the removal of malignant tumors and benign lesions of the anterior skull base. Neurosurg Rev. 2004;27:205-13 pubmed
    ..However, in patients with large malignant tumors, the en bloc resection via the combined craniofacial/subcranial approach achieved better outcome...