pleomorphic adenoma

Summary

Summary: A benign, slow-growing tumor, most commonly of the salivary gland, occurring as a small, painless, firm nodule, usually of the parotid gland, but also found in any major or accessory salivary gland anywhere in the oral cavity. It is most often seen in women in the fifth decade. Histologically, the tumor presents a variety of cells: cuboidal, columnar, and squamous cells, showing all forms of epithelial growth. (Dorland, 27th ed)

Top Publications

  1. Ihrler S, Weiler C, Hirschmann A, Sendelhofert A, Lang S, Guntinas Lichius O, et al. Intraductal carcinoma is the precursor of carcinoma ex pleomorphic adenoma and is often associated with dysfunctional p53. Histopathology. 2007;51:362-71 pubmed
    Although intraductal carcinoma has been demonstrated in intracapsular carcinoma ex pleomorphic adenoma (CEPA), the morphological and genetic stages of transformation of pleomorphic adenoma (PA) to CEPA are not fully understood...
  2. Soares A, de Araújo V, Juliano P, Altemani A. Angiogenic and lymphangiogenic microvessel density in recurrent pleomorphic adenoma. J Oral Pathol Med. 2009;38:623-9 pubmed publisher
    Recurrent pleomorphic adenoma (RPA) is an uncommon and challenging disease...
  3. Brieger J, Duesterhoeft A, Brochhausen C, Gosepath J, Kirkpatrick C, Mann W. Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin. APMIS. 2008;116:1050-7 pubmed publisher
    ..value of cadherin-11, tenascin, fascin, and mucin-1 as markers for the likelihood of recurrence in pleomorphic adenoma of the parotid gland was examined...
  4. Katori H, Nozawa A, Tsukuda M. Expression of epidermal growth factor receptor, transforming growth factor-alpha and Ki-67 in relationship to malignant transformation of pleomorphic adenoma. Acta Otolaryngol. 2007;127:1207-13 pubmed
    ..The data support the hypothesis that increased epidermal growth factor receptor (EGFR) and transforming growth factor (TGF)-alpha expression is associated with early events in malignant transformation of pleomorphic adenoma (PA).
  5. Shah S, Chandan V, Wilbur D, Khurana K. Glial fibrillary acidic protein and CD57 immunolocalization in cell block preparations is a useful adjunct in the diagnosis of pleomorphic adenoma. Arch Pathol Lab Med. 2007;131:1373-7 pubmed
    The cytologic distinction between pleomorphic adenoma (PA) and adenoid cystic carcinoma (ACC) can be diagnostically challenging in aspirate smears...
  6. Patyal S, Banarji A, Bhadauria M, Gurunadh V. Pleomorphic adenoma of a subconjunctival ectopic lacrimal gland. Indian J Ophthalmol. 2010;58:245-7 pubmed publisher
    This report describes a case of pleomorphic adenoma of an ectopic lacrimal gland arising subconjunctivally in the lateral fornix in a 13-year-old girl. The tumor was removed surgically in toto with the capsule...
  7. Daniels J, Ali I, Al Bakri I, Sumangala B. Pleomorphic adenoma of the palate in children and adolescents: a report of 2 cases and review of the literature. J Oral Maxillofac Surg. 2007;65:541-9 pubmed
  8. Freitas L, Araújo V, Martins M, Chone C, Crespo A, Altemani A. Biomarker analysis in carcinoma ex pleomorphic adenoma at an early phase of carcinomatous transformation. Int J Surg Pathol. 2005;13:337-42 pubmed
    Diagnostic criteria for intracapsular carcinoma ex pleomorphic adenoma (CXPA) are subjective and vary among authors...
  9. Kato H, Kanematsu M, Ando K, Mizuta K, Ito Y, Hirose Y, et al. Ossifying pleomorphic adenoma of the parotid gland: a case report and review. Australas Radiol. 2007;51 Suppl:B173-5 pubmed
    b>Pleomorphic adenoma is the most common parotid gland neoplasm and occasionally arises from the deep lobe of the parotid gland with extension into the parapharyngeal space...

More Information

Publications62

  1. Redaelli de Zinis L, Piccioni M, Antonelli A, Nicolai P. Management and prognostic factors of recurrent pleomorphic adenoma of the parotid gland: personal experience and review of the literature. Eur Arch Otorhinolaryngol. 2008;265:447-52 pubmed
    The aim of this study was to investigate the management and prognostic determinants of recurrent pleomorphic adenoma (RPA)...
  2. Genelhu M, Gobbi H, Arantes D, Cardoso S, Cassali G. Immunolocalization of beta-catenin in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands. Appl Immunohistochem Mol Morphol. 2007;15:273-8 pubmed
    ..Our data showed decreased cell membrane beta-catenin expression in higher-grade tumors suggesting that beta-catenin may play an important role in histologic differentiation and transition to malignant phenotype of Ca ex-PA...
  3. Hellin Meseguer D, Melgarejo Moreno P, Hostalet E. Carcinoma ex pleomorphic adenoma of the submandibular gland with distant metastases. B-ENT. 2007;3:27-9 pubmed
    A case of metastatic carcinoma ex pleomorphic adenoma (PA) of the submandibular gland is reported. While reports of local recurrence of this cancer are numerous, few cases of distant metastases have been reported...
  4. Nakamori K, Ohuchi T, Hasegawa T, Hiratsuka H. Carcinoma ex pleomorphic adenoma of the buccal region is composed of salivary duct carcinoma and squamous cell carcinoma components. Int J Oral Maxillofac Surg. 2009;38:1116-8 pubmed publisher
    ..characteristics consistent with squamous cell carcinoma (SCC), salivary duct carcinoma (SDC) and pleomorphic adenoma (PA). The SCC nests showed no continuity with the buccal mucosa...
  5. Wittekindt C, Streubel K, Arnold G, Stennert E, Guntinas Lichius O. Recurrent pleomorphic adenoma of the parotid gland: analysis of 108 consecutive patients. Head Neck. 2007;29:822-8 pubmed
    Surgery for recurrent parotid pleomorphic adenoma is a challenging problem.
  6. Rodríguez Fernández J, Mateos Micas M, Martinez Tello F, Berjón J, Montalvo J, Forteza González G, et al. Metastatic benign pleomorphic adenoma. Report of a case and review of the literature. Med Oral Patol Oral Cir Bucal. 2008;13:E193-6 pubmed
    b>Pleomorphic adenoma (PA), originally called mixed tumour, is the most common neoplasm of the salivary glands and is generally accepted as benign biologically. Occasionally PA may give rise to metastasis...
  7. Di Palma S, Lambros M, Savage K, Jones C, Mackay A, Dexter T, et al. Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells. J Clin Pathol. 2007;60:492-9 pubmed
    ..When found within pleomorphic adenomas (PAs), cells with OC may be perceived as evidence of malignancy, and lead to a misdiagnosis of carcinoma ex pleomorphic adenoma (CaExPa).
  8. Yuan W, Hsu H, Chou Y, Hsueh H, Tseng T, Tiu C. Gray-scale and color Doppler ultrasonographic features of pleomorphic adenoma and Warthin's tumor in major salivary glands. Clin Imaging. 2009;33:348-53 pubmed publisher
    Our aim was to assess the specific ultrasonic characteristics of pleomorphic adenoma and Warthin's tumor in major salivary glands.
  9. Yang S, Wang H, Wang X, Guo L, Tang X, Gao Q, et al. Expression of CD44V6 in parotid pleomorphic adenoma and carcinoma ex pleomorphic adenoma. Expert Opin Investig Drugs. 2010;19 Suppl 1:S101-8 pubmed publisher
    ..This pattern of expression might be associated with carcinogenesis of parotid pleomorphic adenoma (PPA) which is not widely studied...
  10. Gedlicka C, Item C, Wögerbauer M, Martinek H, Heiduschka G, Erovic B, et al. Transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma of the parotid gland is independent of p53 mutations. J Surg Oncol. 2010;101:127-30 pubmed publisher
    ..retrospective study was performed to evaluate the status of p53 in pleomorphic adenomas and carcinomas ex pleomorphic adenoma in the parotid gland...
  11. Tamiolakis D, Chimona T, Georgiou G, Proimos E, Nikolaidou S, Perogamvrakis G, et al. Accessory parotid gland carcinoma ex pleomorphic adenoma. Case study diagnosed by fine needle aspiration. Stomatologija. 2009;11:37-40 pubmed
    ..7% of all parotid gland tumors. Carcinoma ex pleomorphic adenoma arises from a pre-existing benign mixed tumor...
  12. Tsutsumi T, Nakajima N, Hirose T, Watanabe K. Total-length invasion of the facial nerve by parotid carcinoma ex pleomorphic adenoma. Auris Nasus Larynx. 2009;36:618-22 pubmed publisher
    ..Pathological examination revealed the salivary duct carcinoma subtype of carcinoma ex pleomorphic adenoma. Within the facial nerve, the epineurium, perineurium and endoneurium were affected throughout its length...
  13. Markou K, Karasmanis I, Vlachtsis K, Petridis D, Nikolaou A, Vital V. Primary pleomorphic adenoma of the external ear canal. Report of a case and literature review. Am J Otolaryngol. 2008;29:142-6 pubmed publisher
    ..skin of the external auditory meatus that may give rise to (a) benign tumors such as ceruminous adenoma, pleomorphic adenoma, and syringocystadenoma papilliferum, and (b) malignant tumors such as ceruminous adenocarcinoma, adenoid ..
  14. Mendelsohn A, Bhuta S, Calcaterra T, Shih H, Abemayor E, St John M. Parapharyngeal space pleomorphic adenoma: a 30-year review. Laryngoscope. 2009;119:2170-4 pubmed publisher
    To evaluate the treatment results of pleomorphic adenoma (PA) of the parapharyngeal space at a single institution during a 30-year period.
  15. Sheedy S, Welker K, DeLone D, Gilbertson J. CNS metastases of carcinoma ex pleomorphic adenoma of the parotid gland. AJNR Am J Neuroradiol. 2006;27:1483-5 pubmed
    ..This case report presents the clinical and radiographic features of a rare case of biopsy proved brain and spinal cord metastases arising from carcinoma ex PA of the parotid gland...
  16. Luers J, Wittekindt C, Streppel M, Guntinas Lichius O. Carcinoma ex pleomorphic adenoma of the parotid gland. Study and implications for diagnostics and therapy. Acta Oncol. 2009;48:132-6 pubmed publisher
    Carcinoma ex pleomorphic adenoma (CXPA) is a rare parotid malignancy and until today no standardized concept exists for its therapy apart from recommendations for parotid carcinoma in general...
  17. Larbcharoensub N, Cert P, Tungkeeratichai J, Prakunhungsit S, Narkwong L, Leopairut J. Expression of hormonal receptor in patients with metastasizing pleomorphic adenoma of the major salivary gland; a clinicopathological report of three cases. J Med Assoc Thai. 2009;92:1250-5 pubmed
    Metastasizing pleomorphic adenoma is an uncommon malignant tumor of the salivary gland demonstrating benign epithelial and modified myoepithelial elements intermingling with tissue of mucoid, myxoid, or chondroid appearance that ..
  18. Zbären P, Zbären S, Caversaccio M, Stauffer E. Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngol Head Neck Surg. 2008;138:601-5 pubmed publisher
    To analyze a series of carcinoma ex pleomorphic adenoma (CXPA) and to assess the diagnostic difficulties.
  19. Demasi A, Furuse C, Soares A, Altemani A, Araújo V. Peroxiredoxin I, platelet-derived growth factor A, and platelet-derived growth factor receptor alpha are overexpressed in carcinoma ex pleomorphic adenoma: association with malignant transformation. Hum Pathol. 2009;40:390-7 pubmed publisher
    Carcinoma ex pleomorphic adenoma is a rare salivary gland malignancy...
  20. Dhanuthai K, Sappayatosok K, Kongin K. Pleomorphic adenoma of the palate in a child: a case report. Med Oral Patol Oral Cir Bucal. 2009;14:E73-5 pubmed
    ..We reported the first case of palatal pleomorphic adenoma in a 13 year-old child from Thailand...
  21. Takahama A, da Cruz Perez D, Magrin J, de Almeida O, Kowalski L. Giant pleomorphic adenoma of the parotid gland. Med Oral Patol Oral Cir Bucal. 2008;13:E58-60 pubmed
    b>Pleomorphic adenoma is the most common type of all benign and malignant salivary gland tumors, involving more frequently the parotid gland...
  22. Tsukahara K, Suzuki M, Tokashiki R, Motohashi R, Iwaya K. Pleomorphic adenoma of the external auditory canal complicated by hearing loss secondary to chronic otitis media. Auris Nasus Larynx. 2006;33:183-6 pubmed
    b>Pleomorphic adenoma (PA) rarely occurs in the external auditory canal (EAC). A case of PA complicated with chronic otitis media is reported...
  23. John B, Griffiths C, Ebbs S. Pleomorphic adenoma of the breast should be excised with a cuff of normal tissue. Breast J. 2007;13:418-20 pubmed
    b>Pleomorphic adenoma is a benign tumor found rarely in the breast but commonly in the salivary gland. Unlike the salivary gland variant management guidelines are poorly defined in the breast...
  24. Liao Y, Zeng H, Wang X, Huang Y, Chen N, Ge B, et al. Expression patterns and prognostic significance of inhibitor of apoptosis proteins in adenoid cystic carcinoma and pleomorphic adenoma of lachrymal gland. Exp Eye Res. 2009;88:4-11 pubmed publisher
    ..Adenoid cystic carcinoma (ACC) of lachrymal gland is a malignant tumor with a poor prognosis, while, pleomorphic adenoma (PA) is the benign tumor of lachrymal gland epithelia...
  25. Lotufo M, Júnior C, Mattos J, França C. Pleomorphic adenoma of the upper lip in a child. J Oral Sci. 2008;50:225-8 pubmed
    This case report describes a rare and unusual lesion found in a 12-year-old boy, which was diagnosed as pleomorphic adenoma of the minor salivary glands in the upper lip. The tumor was a circumscribed, submucosal nodule, about 2...
  26. Nakajima Y, Kishimoto T, Nagai Y, Yamada M, Iida Y, Okamoto Y, et al. Expressions of androgen receptor and its co-regulators in carcinoma ex pleomorphic adenoma of salivary gland. Pathology. 2009;41:634-9 pubmed publisher
    ..The expression of AR has been reported in carcinoma ex pleomorphic adenoma (CXPA) of salivary gland, however AR gene status and the expressions of cofactors for AR signalling have ..
  27. Cho N, Han H, Soh Y, Son H. Overexpression of cyclooxygenase-2 correlates with cytoplasmic HuR expression in salivary mucoepidermoid carcinoma but not in pleomorphic adenoma. J Oral Pathol Med. 2007;36:297-303 pubmed
    ..HuR is an mRNA-binding protein that controls the stability of certain transcripts including COX-2...
  28. Lee S, Lee C, Silver S, Kuhar S. Nasopharyngeal pleomorphic adenoma in the adult. Laryngoscope. 2006;116:1281-3 pubmed
    Salivary gland tumors account for less than 5% of all neoplasms in the head and neck, with pleomorphic adenoma being the most common type...
  29. Matsubayashi S, Yoshihara T. Carcinoma ex pleomorphic adenoma of the salivary gland: an immunohistochemical study. Eur Arch Otorhinolaryngol. 2007;264:789-95 pubmed
    ..and sex steroid hormone receptors were investigated immunohistochemically in ten cases of carcinoma ex pleomorphic adenoma (Ca-ex-PA) of the salivary glands...
  30. do Prado R, Consolaro A, Taveira L. Expression of betacatenin in carcinoma in pleomorphic adenoma, pleomorphic adenoma and normal salivary gland: an immunohistochemical study. Med Oral Patol Oral Cir Bucal. 2006;11:E247-51 pubmed
    ..The objective of this study was to detect the expression of beta-catenin in pleomorphic adenomas, carcinomas in pleomorphic adenomas and normal salivary glands to discuss its role in the development of these two lesions...
  31. Katori H, Nozawa A, Tsukuda M. Increased expression of cyclooxygenase-2 and Ki-67 are associated with malignant transformation of pleomorphic adenoma. Auris Nasus Larynx. 2007;34:79-84 pubmed
    ..present study, we attempted to identify cyclooxygenase-2 (COX-2) expression and Ki-67 index in carcinoma ex-pleomorphic adenoma (Ca ex-PA) using quantitative immunohistochemical analysis and to compare the benign component of the ..
  32. Mizukami Y, Takayama T, Takemura A, Ichikawa K, Onoguchi M, Miyati T, et al. Pleomorphic adenoma of the breast. Radiat Med. 2008;26:442-5 pubmed publisher
    b>Pleomorphic adenoma is a very rare benign tumor of the breast. Only 70 cases have been reported in the world literature...
  33. Mendenhall W, Mendenhall C, Werning J, Malyapa R, Mendenhall N. Salivary gland pleomorphic adenoma. Am J Clin Oncol. 2008;31:95-9 pubmed publisher
    We discuss the optimal treatment and outcomes for pleomorphic adenoma of the salivary glands by reviewing the pertinent literature. Pleomorphic adenoma is the most common benign salivary gland neoplasm...
  34. Kato H, Kanematsu M, Mizuta K, Ito Y, Hirose Y. Carcinoma ex pleomorphic adenoma of the parotid gland: radiologic-pathologic correlation with MR imaging including diffusion-weighted imaging. AJNR Am J Neuroradiol. 2008;29:865-7 pubmed publisher
    We present 4 cases of carcinoma ex pleomorphic adenoma of the parotid gland...
  35. Xiao L, Lu X, Zhu X, Jones T, Cheng L. Metastasising pleomorphic adenoma of the parotid presenting as a solitary kidney mass. Pathology. 2008;40:87-9 pubmed
  36. Silva S, Costa Junior G, Brant Filho A, Faria P, Loyola A. Metachronous bilateral pleomorphic adenoma of the parotid gland. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:333-8 pubmed
    ..Only on the left side some facial nerve branches were removed that induced partial paralysis in the patient. A review of the pertinent literature is included...
  37. Alyahya G, Stenman G, Persson F, Prause J, Skjødt K, Saunte J, et al. Pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring. Ophthalmology. 2006;113:879-82 pubmed
    To describe a patient with pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring in the lower lid and to illustrate the immunohistochemical and molecular cytogenetics.
  38. Sharon E, Kelly R, Szabo E. Sustained response of carcinoma ex pleomorphic adenoma treated with trastuzumab and capecitabine. Head Neck Oncol. 2010;2:12 pubmed publisher
    Carcinoma ex pleomorphic adenoma is a rare histologic subtype of salivary gland cancer with an overall poor prognosis...
  39. Siddaraju N, Singh N, Muniraj F, Jothilingam P, Kumar S, Basu D, et al. Preoperative cytodiagnosis of pleomorphic adenoma with extensive lipometaplasia: a case report. Acta Cytol. 2009;53:457-9 pubmed
    b>Pleomorphic adenoma with extensive lipometaplasia is a rare, benign tumor of salivary gland origin...
  40. Witt R, Rejto L. Pleomorphic adenoma: extracapsular dissection versus partial superficial parotidectomy with facial nerve dissection. Del Med J. 2009;81:119-25 pubmed
    ..ECD does not dissect the facial nerve. PSP dissects the facial nerve and provides a 1-2 cm margin around the tumor...
  41. Guo S, Cheuk W, Chan J. Pleomorphic adenoma with mucinous and squamous differentiation: a mimicker of mucoepidermoid carcinoma. Int J Surg Pathol. 2009;17:335-7 pubmed publisher
    b>Pleomorphic adenoma with foci of squamous and mucinous differentiation can potentially be misdiagnosed as low-grade mucoepidermoid carcinoma...
  42. Siddaraju N, Murugan P, Basu D, Verma S. Preoperative cytodiagnosis of cystic pleomorphic adenoma with squamous metaplasia and cholesterol crystals: a case report. Acta Cytol. 2009;53:101-4 pubmed
    b>Pleomorphic adenoma with extensive squamous metaplasia and cystic change may cause diagnostic confusion both in cytology and histopathology, which stresses the need for a guarded approach while interpreting such lesions...
  43. Akan H, Yildiz L, Unal R. Carcinoma ex pleomorphic adenoma of the minor salivary gland with pulmonary metastasis. Diagn Interv Radiol. 2008;14:3-5 pubmed
    Carcinoma ex pleomorphic adenoma is an exceedingly rare neoplasm of the minor salivary gland. Prognostic parameters are recurrence, capsular invasion, and metastasis...
  44. Patel R, Rose B, Bawdon H, Hong A, Lee C, Fredericks S, et al. Cyclin D1 and p16 expression in pleomorphic adenoma and carcinoma ex pleomorphic adenoma of the parotid gland. Histopathology. 2007;51:691-6 pubmed
    To compare cyclin D1 and p16(ink4) (p16) expression in normal tissue, pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) of the parotid gland.
  45. Johnson J, Ferlito A, Fagan J, Bradley P, Rinaldo A. Role of limited parotidectomy in management of pleomorphic adenoma. J Laryngol Otol. 2007;121:1126-8 pubmed
    There is continued controversy over the extent of parotidectomy required for removal of a benign pleomorphic adenoma from the parotid gland...
  46. Soares A, Juliano P, Araujo V, Metze K, Altemani A. Angiogenic switch during tumor progression of carcinoma ex-pleomorphic adenoma. Virchows Arch. 2007;451:65-71 pubmed
    We analyzed the tumor vascularization in carcinomas ex-pleomorphic adenoma (CXPA) to investigate the angiogenic switch during the malignant transformation of pleomorphic adenoma (PA) to carcinoma and during tumor progression...
  47. Chen A, Garcia J, Bucci M, Quivey J, Eisele D. The role of postoperative radiation therapy in carcinoma ex pleomorphic adenoma of the parotid gland. Int J Radiat Oncol Biol Phys. 2007;67:138-43 pubmed
    To evaluate the impact of postoperative radiation therapy on the clinical course of patients with carcinoma ex pleomorphic adenoma of the parotid gland.
  48. Dykgraaf R, van Veen M, van Bekkum de Jonge E, Gerretsen J, De Jong D, Burger C. Pleomorphic adenoma of the vulva: a review illustrated by a clinical case. Int J Gynecol Cancer. 2006;16:920-3 pubmed
    The pleomorphic adenoma of the vulva is an extremely scarce diagnosis. This form of neoplasm is more frequently observed in other topographic sites of the human body...
  49. Kumar S, Reddy P, Prabhakar G. Pleomorphic adenoma of the nasal septum--a case report. Indian J Pathol Microbiol. 2004;47:397-8 pubmed
    b>Pleomorphic adenoma which is also called mixed tumour occur in major salivary glands like parotid and submandibular glands, and is rare in other sites such as the nasal cavity, pharynx, larynx, trachea and lacrimal glands...
  50. Yoshino N, Kubokura H, Yamauchi S, Ohaki Y, Koizumi K, Shimizu K. A true pulmonary carcinosarcoma that required diagnostic differentiation from a pleomorphic adenoma: a case report. Ann Thorac Cardiovasc Surg. 2009;15:42-5 pubmed
    ..lesion that required a diagnostic differentiation from epithelial-mesenchymal mixed neoplasms inclusive of pleomorphic adenoma, and that was diagnosed by immunohistochemical staining to be a true carcinosarcoma...
  51. Nakano K, Watanabe T, Shimizu T, Kawakami T. Immunohistochemical characteristics of bone forming cells in pleomorphic adenoma. Int J Med Sci. 2007;4:264-6 pubmed
    Histopathological and immunohistochemical examinations were carried out in a case of pleomorphic adenoma with bone formation, occurring in the chin of a 34-year-old Japanese man...
  52. Katabi N, Gomez D, Klimstra D, Carlson D, Lee N, Ghossein R. Prognostic factors of recurrence in salivary carcinoma ex pleomorphic adenoma, with emphasis on the carcinoma histologic subtype: a clinicopathologic study of 43 cases. Hum Pathol. 2010;41:927-34 pubmed publisher
    Carcinoma ex pleomorphic adenoma is a rare salivary gland neoplasm, especially when the malignant component is only intracapsular/minimally invasive...
  53. de Araujo V, Altemani A, Furuse C, Martins M, de Araujo N. Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncol. 2006;42:1011-6 pubmed
    ..We investigated the immunoprofile of benign MC in intraductal areas of carcinoma ex-pleomorphic adenoma (CXPA), comparing them with the MC in duct-like areas of pleomorphic adenoma, origin of the malignant tumor...