malignant mixed tumor


Summary: A malignant tumor composed of more than one type of neoplastic tissue. (Dorland, 27th ed)

Top Publications

  1. Ezenekwe A, Collins B, Ponder T. Mixed osteoclastic/pleomorphic giant cell tumor of the pancreas: a case report. Acta Cytol. 2005;49:549-53 pubmed
    ..The morphology and immunocytochemical profile raise the possibility that osteoclastic giant cell tumor and pleomorphic giant cell tumor may be different morphologic and biologic expressions of the same tumor. ..
  2. Das T, Raha K, Bandyopadhyay A, Dasgupta A, Ghosh D, Mondal A. Malignant mixed mullerian tumour of the fallopian tube of heterologous variety--a case report. Indian J Pathol Microbiol. 2005;48:354-6 pubmed
    ..A diagnosis of malignant mixed mullerian tumour of the fallopian tube, clinically FIGO stage III was made, which is extremely rare in available literature. ..
  3. Cryns P, Roofthooft N, Tjalma W. Malignant mixed müllerian tumor of the ovary and false negative punctures. Eur J Gynaecol Oncol. 2003;24:70-2 pubmed
    ..If a tumour consists of two components, puncture can miss one, which may lead to undertreatment. Punctures should be discouraged as a diagnostic tool in patients in whom an ovarian malignancy is suspected. ..
  4. Zamecnik M, Staník M. Dedifferentiated mixed stromal-smooth muscle tumor of the uterus. Report of a case. Cesk Patol. 2006;42:81-5 pubmed
    ..It shows that extensive sampling/histological search may be needed for recognition of a minor component in a dedifferentiated tumor. ..
  5. Qureshi A, Barakzai A, Sahar N, Gulzar R, Ahmad Z, Hassan S. Spectrum of malignancy in mixed tumors of salivary gland: a morphological and immunohistochemical review of 23 cases. Indian J Pathol Microbiol. 2009;52:150-4 pubmed
    ..The occurrence of various malignancies suggests that this phenomenon is not very uncommon and should be looked for when reporting a mixed tumor. ..
  6. Piana S, Cavazza A, Corrado S, Putrino I, Gardini G. Combined small cell carcinoma and clear cell carcinoma of the gallbladder: report of a case and review of the literature. Pathol Res Pract. 2002;198:821-4 pubmed
    ..The patient died after 3 years following treatment with combination chemotherapy. The histologic and immunohistochemical profile of the lesion is described, together with a brief review of the pertinent bibliography. ..
  7. Nistal M, Yébenes Gregorio L, Esteban Rodríguez I, Bernaldez R, Regadera J. Malignant mixed tumor of the larynx. Head Neck. 2005;27:166-70 pubmed
    b>Malignant mixed tumor of the larynx is a very rare neoplasm; only five cases have been reported, three in the English-language literature...
  8. Ikeda T, Nagoya S, Kawaguchi S, Wada T, Ohuchi T, Satoh M. Metastasis from a mixed tumour of the salivary gland. Lancet Oncol. 2003;4:702 pubmed
  9. Acikalin M, Ozalp S, Yalcin O, Peker B. Mixed serous and endometrioid carcinoma of the fallopian tube: a case report with literature review. Eur J Gynaecol Oncol. 2005;26:342-4 pubmed
    ..On the contrary, mixed cell types of fallopian tube carcinoma have rarely been reported in the literature. A case of mixed serous and endometrioid carcinoma of the fallopian tube is presented and the related literature is reviewed. ..

More Information


  1. Sanada Y, Yoshida K. A case of benign intraductal papillary mucinous neoplasm of the pancreas containing two major subtypes. J Gastrointestin Liver Dis. 2008;17:457-60 pubmed
    ..Our observations suggest that gastric-type epithelium is a precursor of intestinal-type lesions in the stepwise progression of IPMN. ..
  2. Rowsell C, Fleshner N, Marrano P, Squire J, Evans A. Papillary renal cell carcinoma within a renal oncocytoma: case report of an incidental finding of a tumour within a tumour. J Clin Pathol. 2007;60:426-8 pubmed
    ..The cells in the papillary tumour contained three copies, whereas the oncocytoma cells contained only two per nucleus. To our knowledge, this is the first report of a papillary RCC being identified within an oncocytoma. ..
  3. Numata T, Hiruma K, Tsukuda T, Asano T. [Malignant mixed tumor]. Gan To Kagaku Ryoho. 2004;31:314-7 pubmed
    The term "malignant mixed tumor" is usually synonymous with "carcinoma in pleomorphic adenoma," a secondary carcinoma developing in pre-existing pleomorphic adenoma...
  4. Miyauchi Y, Tanji N, Miyazaki T, Shimamoto K, Sakayama K, Yokoyama M. Malignant salivary gland-type mixed tumour of the kidney. Pathology. 2008;40:431-4 pubmed publisher
  5. Akamatsu Y, Murakami K, Watanabe M, Jokura H, Tominaga T. Malignant peripheral nerve sheath tumor arising from benign vestibular schwannoma treated by gamma knife radiosurgery after two previous surgeries: a case report with surgical and pathological observations. World Neurosurg. 2010;73:751-4 pubmed publisher
    ..The coexistence of benign and malignant components might indicate that the present MPNST had arisen from the benign schwannoma by transformation in association with GKRS. ..
  6. Battisti S, Renaudin K, Rigaud J, Hetet J, Dugardin F, Le Normand L, et al. [Mixed epithelial and stromal tumour of the kidney]. Prog Urol. 2004;14:210-2 pubmed
    ..The prognosis of these tumours is usually very favourable, although caution is advised in view of the limited number of published cases and a recent report of a malignant case. ..
  7. Chatelain D, Parc Y, Christin Maitre S, Parc R, Flejou J. Mixed ductal-pancreatic polypeptide-cell carcinoma of the pancreas. Histopathology. 2002;41:122-6 pubmed
    ..The histogenesis of mixed carcinoma of the pancreas is still uncertain but the over-expression of p53 and Bcl-2 could play a major role in the neoplastic progression of the ductal component. ..
  8. Kim K, Han E, Lee E, Park H, Kim I, Kim Y. Epstein-Barr virus infection in sarcomatoid renal cell carcinoma tissues. BJU Int. 2005;96:547-52 pubmed
    ..The present study suggests that sarcomatoid RCC modulates a function of EBV-specific T cells controlling EBV replication, or stimulates differentiation of memory B cells into plasma cells. ..
  9. Mohan D, Rao G, Swalsky P, Bakker A, Martinez A, Finkelstein S. Microdissection genotyping of mixed glial and primitive neuroectodermal central nervous system neoplasm. Arch Pathol Lab Med. 2004;128:1161-4 pubmed
    ..The efficacy of the approach used for molecular analysis of this complex neoplasm and the implication of the genotypic findings are discussed. ..
  10. Bayazit Y, Kanlikama M, Bakir K, Ucak R, Mumbuc S, Ozer E. Malignant mixed tumor of the larynx: a case report. Rev Laryngol Otol Rhinol (Bord). 2001;122:249-51 pubmed
    ..An additional case of laryngeal MMT presented in a forty-five year old man, and the diagnostic, immunohistochemical (S-100, actin, vimentin, epithelial membrane antigen) and therapeutic procedures were presented. ..
  11. de Pinieux G, Beabout J, Unni K, Sim F. Primary mixed tumor of bone. Skeletal Radiol. 2001;30:534-6 pubmed
    ..No other primary site has become apparent on follow-up of 5 years. Although mixed tumors detected by bone biopsy are likely to be metastatic, they may rarely represent primary bone neoplasms. ..
  12. Lee J, Georgi D, Wang B. Malignant myoepithelial tumor of soft tissue: a report of two cases of the lower extremity and a review of the literature. Ann Diagn Pathol. 2007;11:190-8 pubmed
    ..Two cases of lower extremity malignant myoepithelial tumors are reported. One case of malignant mixed tumor overlying the gastrocnemius muscle was treated with wide local excision, but metastasized to regional ..
  13. Humble S, Carter E. Pathologic quiz case: a right adnexal mass in a postmenopausal patient. Malignant mixed müllerian tumor with heterologous elements arising in the fallopian tube. Arch Pathol Lab Med. 2004;128:e161-2 pubmed
  14. Stomeo F, Rocca P, Bozzo C, Bianchini C, Meloni F, Pastore A. Laryngeal true malignant mixed tumor. Head Neck. 2009;31:556-60 pubmed publisher
    True malignant mixed tumor, also known as carcinosarcoma, is a salivary gland type malignant neoplasm, which is extremely rare, and only a few cases arising in the larynx have been previously reported...
  15. Tohme C, Mattar W, Ghorra C. Extra-adrenal composite pheochromocytoma-ganglioneuroma. Saudi Med J. 2006;27:1594-7 pubmed
  16. Demirag F, Topcu S, Kurul C, Memis L, Altinok T. Malignant pleomorphic adenoma (malignant mixed tumor) of the trachea: a case report and review of the literature. Eur Arch Otorhinolaryngol. 2003;260:96-9 pubmed
    A case of malignant mixed tumor of the trachea in a 56-year-old man is described. His tumor was removed by segmental tracheal resection, and end-to-end anastomosis was performed...
  17. Picken M, Fresco R. Mixed epithelial and stromal tumor of the kidney: preliminary immunohistochemical and electron microscopic studies of the epithelial component. Ultrastruct Pathol. 2005;29:283-6 pubmed
    ..Additional studies are needed to address this issue and electron microscopy should play a significant role in this process. ..
  18. Regalado J. Mixed micropapillary and trophoblastic carcinoma of bladder: report of a first case with new immunohistochemical evidence of urothelial origin. Hum Pathol. 2004;35:382-4 pubmed
  19. Berney D, Warren A, Verma M, Kudahetti S, Robson J, Williams M, et al. Malignant germ cell tumours in the elderly: a histopathological review of 50 cases in men aged 60 years or over. Mod Pathol. 2008;21:54-9 pubmed
    ..We conclude that germ cell tumours, in man aged 60 years or above, present at a later stage than in younger men, and although most are seminomas, non-seminomatous tumours may occur with a wide spectrum of morphology...
  20. Iczkowski K, Montironi R. Adenoid cystic/basal cell carcinoma of the prostate strongly expresses HER-2/neu. J Clin Pathol. 2006;59:1327-30 pubmed
    ..Benign acini expressed HER-2/neu only in the basal layer. The finding of strong, consistent HER-2/neu expression in ACBCC suggests that treatment with Herceptin (trastuzumab) may be effective in patients with this rare tumour. ..
  21. Vicioso L, Gallego E, Sanz A. Cutaneous mixed tumor with lipomatous stroma. J Cutan Pathol. 2006;33 Suppl 2:35-8 pubmed
    ..Together with a few other cases in the skin and parotid gland, this report shows how massive adipose differentiation can arise in a mixed tumor of the skin. ..
  22. Mentzel T, Requena L, Kaddu S, Soares de Aleida L, Sangueza O, Kutzner H. Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. J Cutan Pathol. 2003;30:294-302 pubmed
    ..Further studies with extended follow-up information are necessary to establish prognostic factors. ..
  23. Jung J, Lee H, Park C, Lee J, Lee K. Merkel cell carcinoma combined with squamous cell carcinoma. J Dermatol. 2007;34:671-3 pubmed
  24. Volker H, Mühlmeier G, Maier H, Kraft K, Muller Hermelink H, Zettl A. True malignant mixed tumour (carcinosarcoma) of submandibular gland--a rare neoplasm of monoclonal origin?. Histopathology. 2007;50:795-8 pubmed
  25. Luong T, Pilozzi E, Bearzi I, Bordi C. Mucosal colonization of gastric endocrine tumors mimicking mixed neoplasms. Virchows Arch. 2008;452:169-74 pubmed
    ..Although mucosal entrapment by the tumor cannot be ruled out, they more likely reflect a hitherto unrecognized mechanism of mucosal colonization of gastric endocrine tumors. ..
  26. Xin W, Paulino A. Prognostic factors in malignant mixed tumors of the salivary gland: correlation of immunohistochemical markers with histologic classification. Ann Diagn Pathol. 2002;6:205-10 pubmed
    b>Malignant mixed tumor of salivary glands is a rare tumor whose variable behavior and prognosis are related for the most part to the clinical stage and histologic grade of the carcinomatous component...
  27. Seethala R, Barnes E, Hunt J. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31:44-57 pubmed
    ..Immunohistochemistry can aid diagnosis by highlighting the biphasic nature of the tumor...
  28. Callister M, Ramondetta L, Jhingran A, Burke T, Eifel P. Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome. Int J Radiat Oncol Biol Phys. 2004;58:786-96 pubmed
    ..To determine the survival outcomes, prognostic factors, and patterns of failure in patients with malignant mixed Müllerian tumor (MMMT) of the uterus...
  29. Ergul E, Gozetlik E. Does percutaneous thyroid laser ablation induce mixed papillary and medullary thyroid carcinoma?. Acta Chir Belg. 2010;110:228-31 pubmed
    ..This report describes the first case of thyroid carcinoma that demonstrated both medullary carcinoma and papillary components in the thyroid, which might occur due to percutaneous thyroid laser ablation...
  30. Fowler M, Fowler J, Ducatman B, Barnes L, Hunt J. Malignant mixed tumors of the salivary gland: a study of loss of heterozygosity in tumor suppressor genes. Mod Pathol. 2006;19:350-5 pubmed
    ..Furthermore, these data support prior studies that suggest a common clonal origin for the benign and malignant components of carcinomas ex pleomorphic adenoma...
  31. Tsunezuka Y, Shimizu Y, Tanaka N, Takayanagi T, Kawano M. Positron emission tomography in relation to Noguchi's classification for diagnosis of peripheral non-small-cell lung cancer 2 cm or less in size. World J Surg. 2007;31:314-7 pubmed
    ..The purpose of this study was to examine the accuracy of( 18)F-FDG-PET in relation to Noguchi's classification in the diagnosis of small peripheral non-small-cell lung cancer...
  32. Nangue C, Bron L, Portmann L, Volante M, Ris H, Monnier P, et al. Mixed medullary-papillary carcinoma of the thyroid: report of a case and review of the literature. Head Neck. 2009;31:968-74 pubmed publisher
    ..Mixed medullary-follicular thyroid carcinoma denotes a rare and heterogeneous group of tumors displaying morphological and immunophenotypical features of both origins within the same lesion...
  33. Brandwein Gensler M, Urken M, Wang B. Collision tumor of the thyroid: a case report of metastatic liposarcoma plus papillary thyroid carcinoma. Head Neck. 2004;26:637-41 pubmed
    ..Carcinomas, most commonly renal cell carcinoma, are the likeliest group of neoplasms to metastasize to the thyroid. Soft tissue sarcomas metastasize to the thyroid with a much lower frequency...
  34. Koo H, Jang J, Hong S, Shong Y, Gong G. Renal cell carcinoma metastatic to follicular adenoma of the thyroid gland. A case report. Acta Cytol. 2004;48:64-8 pubmed
    ..Differential diagnosis from primary thyroid tumor is often difficult both clinically and pathologically. We report a case of metastatic renal cell carcinoma in follicular adenoma of the thyroid gland...
  35. Mortele K, Peters H, Odze R, Glickman J, Jajoo K, Banks P. An unusual mixed tumor of the pancreas: sonographic and MDCT features. JOP. 2009;10:204-8 pubmed
    ..Mixed tumors of the pancreas are exceedingly rare...
  36. Kang M, Yoon H. Mixed tumor of the vagina: a case report. J Korean Med Sci. 2002;17:845-8 pubmed
    ..Positive reaction for vimenin and cytokeratin of stromaltype spindle cells and presence of desmosome-like structures and tonofilaments on electron microscopic examination suggested the epithelial origin of the stromaltype spindle cells...
  37. Brunetti B, Sarli G, Marcato P, Benazzi C. Histochemical and immunohistochemical characterization of canine mammary mucinous carcinoma. J Comp Pathol. 2003;129:131-6 pubmed
    ..5 and 1.0, and mucicarmine positivity...
  38. Ho S, Ho T. Malignant mixed Mullerian tumours of the uterus--a ten-year experience. Singapore Med J. 2002;43:452-6 pubmed
    ..To review the clinico-pathological features of malignant mixed Mullerian tumours of the uterine corpus, their prognosis and treatment outcome...
  39. Sorenmo K, Kristiansen V, Cofone M, Shofer F, Breen A, Langeland M, et al. Canine mammary gland tumours; a histological continuum from benign to malignant; clinical and histopathological evidence. Vet Comp Oncol. 2009;7:162-72 pubmed publisher
    ..015. These findings suggest that canine mammary tumours progress from benign to malignant; malignant tumours may be the end stage of a histological continuum with clinical and histopathological similarities to human breast carcinogenesis...
  40. Ciris M, Zekioglu O, Erhan Y, Kapkac M, Makay O, Ozdemir N. Do clinical and immunohistochemical findings of pure mucinous breast carcinoma differ from mixed mucinous breast carcinoma?. Acta Chir Belg. 2009;109:204-8 pubmed
    ..Even if PMCs and especially smaller PMCs display more favourable prognostic features, including less axillary lymph node involvement, it is appropriate to use sentinel lymph node biopsy to make better axillary assessment...
  41. Lopez Beltran A, Requena M, Alvarez Kindelan J, Quintero A, Blanca A, Montironi R. Squamous differentiation in primary urothelial carcinoma of the urinary tract as seen by MAC387 immunohistochemistry. J Clin Pathol. 2007;60:332-5 pubmed
    ..027) and increases with grade/stage mainly in bladder carcinoma (grade, p = 0.05; stage, p = 0.005). Stage Ta/T1 bladder carcinomas with SqD recurred more (p = 0.021). In conclusion, Mac387 efficiently shows SqD in urothelial tumours...
  42. Fuentealba I, Mullins J. Immunohistochemical demonstration of metallothionein in benign and malignant canine mammary tumours. Histol Histopathol. 1999;14:51-61 pubmed publisher
    ..However, results of this study support the hypothesis that MT has a role in tumour proliferation and tumour progression...
  43. Hashimoto Y, Iwase Y, Mogami T, Tsugaya M, Kohri K. Malignant mesodermal mixed tumor of the ureter. Urol Int. 1998;60:118-20 pubmed
    ..We recently encountered a 7th case of malignant mesodermal mixed tumor of the ureter and describe the case in detail. The etiology of malignant mesodermal mixed tumor is also discussed...
  44. Tsang Y, Chang Y, Lu X, Rao P, Lau C, Wong K. Amplification of MGC2177, PLAG1, PSMC6P, and LYN in a malignant mixed tumor of salivary gland detected by cDNA microarray with tyramide signal amplification. Cancer Genet Cytogenet. 2004;152:124-8 pubmed
    ..We applied microarray technology to detect novel gene amplification in a malignant mixed tumor of salivary gland...
  45. Mieno H, Kuroda K, Tajima S. Bone morphogenetic protein-mediated type II collagen expression in pilomatricoma and cutaneous mixed tumor. J Cutan Pathol. 2005;32:206-11 pubmed
    ..We have previously reported that type II collagen deposition in overlying dermo-epidermal junction (DEJ) of pilomatricoma is mediated by bone morphogenetic protein 2/4 (BMP 2/4) expressed by shadow cells (SCs) of pilomatricoma...
  46. Simon D, Knebel J, Baumgartner W, Aufderheide M, Meyer Lindenberg A, Nolte I. In vitro efficacy of chemotherapeutics as determined by 50% inhibitory concentrations in cell cultures of mammary gland tumors obtained from dogs. Am J Vet Res. 2001;62:1825-30 pubmed
    ..inhibitory concentration (IC-50) of carboplatin, cisplatin, and doxorubicin in cell cultures of mammary gland tumors obtained from dogs and to assess whether in vitro efficacy was within the range of clinically relevant concentrations,..
  47. Zheng H, Li X, Hara T, Masuda S, Yang X, Guan Y, et al. Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas. Virchows Arch. 2008;452:525-34 pubmed publisher
  48. Yilmaz A, Rush D, Soslow R. Endometrial stromal sarcomas with unusual histologic features: a report of 24 primary and metastatic tumors emphasizing fibroblastic and smooth muscle differentiation. Am J Surg Pathol. 2002;26:1142-50 pubmed
  49. Dacic S. Minimally invasive adenocarcinomas of the lung. Adv Anat Pathol. 2009;16:166-71 pubmed publisher
    ..Many morphologic factors seem to play a role in predicting the behavior of these tumors. Depending on the results of ongoing clinical trials, surgical management of these tumors may change in a near future...
  50. Baran J, Hoang M. Apocrine mixed tumor of the skin with a prominent pilomatricomal component. J Cutan Pathol. 2009;36:882-6 pubmed publisher
    ..CK17 labeled the epithelial lining of the keratinous cyst. The presence of follicular and apocrine differentiation within our tumor reinforces the common embryologic derivation of these elements...
  51. Allen T. Recognition of histopathologic patterns of diffuse malignant mesothelioma in differential diagnosis of pleural biopsies. Arch Pathol Lab Med. 2005;129:1415-20 pubmed
    ..Diffuse malignant mesothelioma is generally divided into 3 basic histologic types--epithelial, biphasic, or sarcomatous. However, a great diversity of histologic patterns exists within these 3 basic histologic types...
  52. Deschamps L, Dokmak S, Guedj N, Ruszniewski P, Sauvanet A, Couvelard A. Mixed endocrine somatostatinoma of the ampulla of vater associated with a neurofibromatosis type 1: a case report and review of the literature. JOP. 2010;11:64-8 pubmed
  53. Chimona T, Koutsopoulos A, Malliotakis P, Nikolidakis A, Skoulakis C, Bizakis J. Malignant mixed tumor of the nasal cavity. Auris Nasus Larynx. 2006;33:63-6 pubmed
    ..Carcinoma ex-pleomorphic adenoma is by far the most common subtype. Although unusual sites of these tumors have been published, we report an extremely rare case of a malignant mixed tumor located in the nasal cavity.
  54. Cohen P, Schulze K, Nelson B. Cutaneous carcinoma with mixed histology: a potential etiology for skin cancer recurrence and an indication for Mohs microscopically controlled surgical excision. South Med J. 2005;98:740-7 pubmed
  55. Huang C. Cutaneous carcinoma with mixed histology. South Med J. 2005;98:680 pubmed
  56. Kuroda N, Inui Y, Ohara M, Hirouchi T, Mizuno K, Kubo A, et al. Hyaline globule-like structures in undifferentiated sarcoma cells of malignant müllerian mixed tumor of the fallopian tube. Med Mol Morphol. 2007;40:46-9 pubmed
    ..Finally, pathologists should keep in mind that undifferentiated sarcoma cells in MMMT of the fallopian tube may contain hyaline globule-like structures in the cytoplasm...
  57. Paula L, Zen V, Czepielewski M. [Granulosa-stromal tumor of the ovary: a case of mixed germ cell-cord stromal tumor of the ovary with endocrinological considerations]. Arq Bras Endocrinol Metabol. 2005;49:776-83 pubmed
    ..We review the clinical manifestations of ovarian tumors, classification and staging of sex cord-stromal tumors, follow-up, tumor markers, treatment and prognosis...
  58. Chetty R, Klimstra D, Henson D, Albores Saavedra J. Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Am J Surg Pathol. 2010;34:1163-7 pubmed publisher
  59. Ding C, Yap W, Teo C, Giron D, Chuah K. Tracheal carcinoma ex pleomorphic adenoma: a rare tumour with potential problems in diagnosis. Histopathology. 2007;51:868-71 pubmed
  60. Ohta Y, Suzuki T, Kojima M, Shiokawa A, Mitsuya T. Low-grade endometrial stromal sarcoma with an extensive epithelial-like element. Pathol Int. 2003;53:246-51 pubmed
    ..In the present case, the Ki-67 labeling index was markedly higher in CESS than in ELE. Therefore, a difference in cell proliferative activity between ELE and CESS might underlie a different clinical prognosis...
  61. Erdelyi I, Nieskens D, Van Dijk J, Vass L, Nederbragt H. Immunohistochemical evaluation of versican, in relation to chondroitin sulphate, in canine mammary tumours. Histol Histopathol. 2003;18:1067-80 pubmed publisher
    ..Furthermore, the enhanced versican expression in the invasive areas of malignant tumours indicates the involvement of this proteoglycan in tumour cell invasion...
  62. Bennett A, Mills S, Wick M. Salivary-type neoplasms of the breast and lung. Semin Diagn Pathol. 2003;20:279-304 pubmed
    ..This represents a potential area for future growth in further clarifying these tumors and their behavior...
  63. Cole M, Broaddus R, Thaker P, Landen C, Freedman R. Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis. Nat Clin Pract Oncol. 2008;5:171-5 pubmed publisher
  64. Fujiwara M, Horiguchi M, Inage Y, Horiguchi H, Satoh H, Kamma H. Combined small cell carcinoma in the peripheral lung: importance of appropriate sampling. Acta Cytol. 2005;49:575-8 pubmed
  65. Morikawa T, Goto A, Tomita K, Tsurumaki Y, Ota S, Kitamura T, et al. Recurrent prostatic stromal sarcoma with massive high-grade prostatic intraepithelial neoplasia. J Clin Pathol. 2007;60:330-2 pubmed
    ..Our findings suggest that not only the stromal component but also and the epithelial components of PSS may have malignant potential...
  66. Muller H, Nakchbandi V. Cytoreductive surgery plus intraperitoneal hyperthermic perfusion is an effective treatment for metastasized malignant mixed mesodermal tumours (MMMT)--report of six cases. Eur J Surg Oncol. 2004;30:573-7 pubmed
    ..Thus far, almost 350 cases of MMMT have been recorded in the international medical literature. Due to its rarity, there is no agreement on the best treatment strategy in women with metastasized MMMT...
  67. Ichikawa H, Sugano H, Tanada S, Sawada T, Nakayama K, Yorimitsu S, et al. [Diabetes mellitus with mixed neuroendocrine-neural tumor]. Nihon Naika Gakkai Zasshi. 2002;91:1309-12 pubmed
  68. Maeda D, Fujii A, Yamaguchi K, Tominaga T, Fukayama M, Mori M. Sarcomatoid carcinoma with a predominant basaloid squamous carcinoma component: the first report of an unusual biphasic tumor of the ureter. Jpn J Clin Oncol. 2007;37:878-83 pubmed
    ..We believe that the findings of this case study will increase the morphological diversity used for diagnosing malignant tumors of the ureter...
  69. Mikami M, Tanaka K, Onouchi M, Komiyama S, Ishikawa M, Hirose T. A case of ovarian adenosarcoma with a heterologous rhabdomyosarcoma component: a brief case report. Eur J Obstet Gynecol Reprod Biol. 2004;117:112-4 pubmed
  70. Sutak J, Armstrong J, Rusby J. Squamous cell carcinoma arising in a tall cell papillary carcinoma of the thyroid. J Clin Pathol. 2005;58:662-4 pubmed
    ..The immunohistochemical findings are discussed in detail...
  71. Pelosi G, Rodriguez J, Viale G, Rosai J. Salivary gland-type tumors with myoepithelial differentiation arising in pulmonary hamartoma: report of 2 cases of a hitherto unrecognized association. Am J Surg Pathol. 2006;30:375-87 pubmed of myoepithelioma arising in a otherwise classic hamartoma with cartilage predominance, and a case of malignant mixed tumor arising in a predominantly fibrous hamartoma resembling müllerian adenofibroma...
  72. Ko M, Jeng C, Huang S, Shen J, Tzeng C, Chen S. Primary peritoneal carcinosarcoma (malignant mixed mullerian tumor): Report of a case with five-year disease free survival after surgery and chemoradiation and a review of literature. Acta Oncol. 2005;44:756-60 pubmed
    ..Here we report a case of a primary carcinosarcoma of the pelvic peritoneum with five-year disease-free survival after managing the patient with surgery, chemotherapy and radiotherapy...
  73. Lui P, Tse G, Tan P, Jayaram G, Putti T, Chaiwun B, et al. Fine-needle aspiration cytology of metaplastic carcinoma of the breast. J Clin Pathol. 2007;60:529-33 pubmed
    ..Metaplastic carcinoma of the breast encompasses a heterogeneous group of tumours with variable components of sarcomatoid, squamous or poorly differentiated carcinomas...
  74. Lin W, Li C, Lin C, Hsu H, Chang T, Chen T, et al. Atypical pulmonary metastases from a true malignant mixed tumor of the parotid gland. Korean J Radiol. 2009;10:202-5 pubmed publisher
    A 58-year-old male patient presented with a recurrent true malignant mixed tumor of the parotid gland. Patchy pulmonary opacities were identified with a chest radiograph...
  75. Bertagnolli A, Cassali G, Genelhu M, Costa F, Oliveira J, Gonçalves P. Immunohistochemical expression of p63 and deltaNp63 in mixed tumors of canine mammary glands and its relation with p53 expression. Vet Pathol. 2009;46:407-15 pubmed publisher
    ..Our data support the notion that the decrease of p63 expression, in particular of its isoform DeltaNp63, seems to be an important factor in the development of carcinomas in mixed tumors...
  76. Shono Y, Tsuji T, Horiuchi T, Nakai T, Uchiyama K, Nakatani Y, et al. Nonhepatocytic malignant mixed tumor of the liver in adults: report of a long surviving case. Int Surg. 2008;93:55-8 pubmed
    A primary nonhepatocytic malignant mixed tumor in the liver contains both epithelial and mesenchymal components, and the incidence in adults is extremely rare. A 45-year-old female was admitted because of abdominal fullness...
  77. Pace V, Perentes E. Mixed pituitary adenoma-gangliocytoma in a female albino rat. Acta Neuropathol. 2001;101:277-80 pubmed
    ..Accompanying satellite cells in the neuropil immunostained for glial acidic and S-100 proteins. To the best of our knowledge, the presence of mixed pituitary adenoma-gangliocytoma has not been previously reported in rats...
  78. Kasashima S, Hiroshi M, Toshinori M, Yoshio O. Lipomatous mixed tumor with follicular differentiation of the skin. J Cutan Pathol. 2006;33:389-94 pubmed
    ..To our knowledge, this tumor is the first case of a lipomatous mixed tumor with hair follicular differentiation. The case indicates an additional wide spectrum of histologic appearances of cutaneous mixed tumor...
  79. Shimasaki N, Inoue K, Nishigawa H, Kuroda N, Shuin T. Combined small cell carcinoma and sarcomatoid squamous cell carcinoma in the renal pelvis. Int J Urol. 2005;12:686-9 pubmed
    ..Small cell carcinoma or sarcomatoid squamous cell carcinoma of the renal pelvis is very rare. We believe this is the first such case to be reported in the world...
  80. Ribeiro Silva A, Novello Vilar A, Cunha Mercante A, De Angelo Andrade L. Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation. Int J Gynecol Cancer. 2002;12:223-7 pubmed
    ..To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation...
  81. Rausch T, Benhattar J, Sutter M, Andrejevic Blant S. Thyroid carcinoma with papillary and squamous features: report of a case with histogenetic considerations. Pathol Res Pract. 2010;206:263-9 pubmed publisher
    ..This particular presentation of thyroid carcinoma carries a poor prognosis in 20% of cases, with high recurrence rates and distant metastasis...
  82. Pulitzer M, Amin B, Busam K. Merkel cell carcinoma: review. Adv Anat Pathol. 2009;16:135-44 pubmed publisher
    ..Surgical excision is the treatment of choice, but radiation therapy has also found to be effective. Sentinel lymph node biopsy has become an integral part of the staging of patients with MCC...
  83. Nakagawa T, Kanai Y, Fujimoto H, Kitamura H, Furukawa H, Maeda S, et al. Malignant mixed epithelial and stromal tumours of the kidney: a report of the first two cases with a fatal clinical outcome. Histopathology. 2004;44:302-4 pubmed
  84. Jongsma J, van Montfort E, Vooijs M, Zevenhoven J, Krimpenfort P, van der Valk M, et al. A conditional mouse model for malignant mesothelioma. Cancer Cell. 2008;13:261-71 pubmed publisher
    ..Interestingly, upon Ink4a loss in the latter mice median survival was significantly reduced and all tumors were highly invasive, suggesting that Ink4a loss substantially contributes to the poor clinical outcome of malignant mesothelioma...
  85. Lawrentschuk N, Gyomber D, Bolton D. Renal cell carcinoma following testicular cancer: case report and literature review. Int Urol Nephrol. 2006;38:1-4 pubmed
  86. Witt R. Major salivary gland cancer. Surg Oncol Clin N Am. 2004;13:113-27 pubmed
  87. Williams S, Ellis G, Warnock G. Sialoblastoma: a clinicopathologic and immunohistochemical study of 7 cases. Ann Diagn Pathol. 2006;10:320-6 pubmed
    ..Although a clinical correlation is suggested by a favorable/unfavorable histologic grading system the biologic behavior is nonetheless considered unpredictable...
  88. Mizoshita T, Kataoka H, Kubota E, Shimura T, Mori Y, Wada T, et al. An endocrine cell carcinoma with gastric-and-intestinal mixed phenotype adenocarcinoma component in the stomach. Dig Endosc. 2009;21:258-61 pubmed publisher
    ..The ECC cases with the GI type adenocarcinoma component may have a relatively good prognosis, being similar to the results of advanced gastric cancers from the viewpoint of gastric and intestinal phenotypic expression...