hepatoblastoma

Summary

Summary: A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)

Top Publications

  1. Tomlinson G, Kappler R. Genetics and epigenetics of hepatoblastoma. Pediatr Blood Cancer. 2012;59:785-92 pubmed publisher
    A number of unique genetic features are observed in hepatoblastoma that have provided insights into the origins of hepatoblastoma...
  2. Tsai J, Qiu W, Kohen Avramoglu R, Adeli K. MEK-ERK inhibition corrects the defect in VLDL assembly in HepG2 cells: potential role of ERK in VLDL-ApoB100 particle assembly. Arterioscler Thromb Vasc Biol. 2007;27:211-8 pubmed
    ..Modulation of this pathway in primary hepatocytes also regulates apoB secretion and appears to alter the formation of VLDL-1 sized particles. ..
  3. McLaughlin C, Baptiste M, Schymura M, Nasca P, Zdeb M. Maternal and infant birth characteristics and hepatoblastoma. Am J Epidemiol. 2006;163:818-28 pubmed
    b>Hepatoblastoma is a rare embryonal tumor with unknown etiology. The authors conducted a case-cohort study using public health surveillance data sets to examine perinatal risk factors for hepatoblastoma...
  4. Liu C, Ma Z, Hou J, Zhang H, Liu R, Wu W, et al. Germline traits of human hepatoblastoma cells associated with growth and metastasis. Biochem Biophys Res Commun. 2013;437:120-6 pubmed publisher
    ..Here, we show that germline traits that are present in human hepatoblastoma cells might be associated with the malignant behaviors of these tumor cells...
  5. De Ioris M, Brugieres L, Zimmermann A, Keeling J, Brock P, Maibach R, et al. Hepatoblastoma with a low serum alpha-fetoprotein level at diagnosis: the SIOPEL group experience. Eur J Cancer. 2008;44:545-50 pubmed publisher
    To investigate the characteristics of patients with hepatoblastoma and low serum alpha-fetoprotein (AFP) at diagnosis. Inclusion of all 21 patients accrued onto SIOPEL trials, whose serum AFP was <100ng/ml at diagnosis...
  6. Curia M, Zuckermann M, De Lellis L, Catalano T, Lattanzio R, Aceto G, et al. Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations. Mod Pathol. 2008;21:7-14 pubmed
    b>Hepatoblastoma, a rare embryonic tumor that may arise sporadically or in the context of hereditary syndromes (familial adenomatous polyposis and Beckwith-Wiedemann's) is the most frequent liver cancer of childhood...
  7. Otte J. Progress in the surgical treatment of malignant liver tumors in children. Cancer Treat Rev. 2010;36:360-71 pubmed publisher
    ..For hepatoblastoma, there is a general consensus for combining surgical resection with neoadjuvant (and adjuvant) chemotherapy...
  8. Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, et al. Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells. Biochem J. 2010;429:347-57 pubmed publisher
    ..These results suggest that SREBP-2 and NF-Y are required to trigger cell proliferation through the induction of FDPS expression and that the pharmacological action of zoledronic acid is involved in this pathway. ..
  9. Avila L, Luis A, Hernandez F, Garcia Miguel P, Jara P, Andres A, et al. Liver transplantation for malignant tumours in children. Eur J Pediatr Surg. 2006;16:411-4 pubmed
    ..We report on 12 patients, aged 6 months to 14 years, with hepatic malignant tumours: 11 with hepatoblastoma and 1 with fibrolamellar hepatocelullar carcinoma without cirrhosis...

More Information

Publications87

  1. Iacob D, Serban A, Fufezan O, Badea R, Iancu C, Mitre C, et al. Mixed hepatoblastoma in child. Case report. Med Ultrason. 2010;12:157-62 pubmed
    b>Hepatoblastoma represents the child's most frequent malignant hepatic tumor. We present the case of a one-year old prematurely born patient with an abdominal mass. Ultrasound and CT scan demonstrated a solid hepatic tumor...
  2. Yoshida R, Ogata T, Masawa N, Nagai T. Hepatoblastoma in a Noonan syndrome patient with a PTPN11 mutation. Pediatr Blood Cancer. 2008;50:1274-6 pubmed publisher
    ..Noonan syndrome (NS) is occasionally associated with embryonal solid tumors, there has been no report of hepatoblastoma in NS...
  3. Zsiros J, Maibach R, Shafford E, Brugieres L, Brock P, Czauderna P, et al. Successful treatment of childhood high-risk hepatoblastoma with dose-intensive multiagent chemotherapy and surgery: final results of the SIOPEL-3HR study. J Clin Oncol. 2010;28:2584-90 pubmed publisher
    ..designed preoperative chemotherapy regimen in an attempt to improve the cure rate of children with high-risk hepatoblastoma. High risk was defined as follows: tumor in all liver sections (ie, Pretreatment Extension IV [PRETEXT-IV]), ..
  4. Pham T, Iqbal C, Grams J, Zarroug A, Wall J, Ishitani M, et al. Outcomes of primary liver cancer in children: an appraisal of experience. J Pediatr Surg. 2007;42:834-9 pubmed
    b>Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the most common primary liver cancers in children. Recent advances in management of pediatric liver cancer have improved disease-specific survival (DSS)...
  5. Wang Y, Liu H. Adult hepatoblastoma: systemic review of the English literature. Dig Surg. 2012;29:323-30 pubmed publisher
    To review all the case reports or case series of patients with adult hepatoblastoma. A search of all case reports on adult hepatoblastoma in the English literature was performed using the PubMed database...
  6. Lieber J, Eicher C, Wenz J, Kirchner B, Warmann S, Fuchs J, et al. The BH3 mimetic ABT-737 increases treatment efficiency of paclitaxel against hepatoblastoma. BMC Cancer. 2011;11:362 pubmed publisher
    The primary goal of current chemotherapy in hepatoblastoma (HB) is reduction of tumour volume and vitality to enable complete surgical resection and reduce risk of recurrence or metastatic disease...
  7. Rumbajan J, Maeda T, Souzaki R, Mitsui K, Higashimoto K, Nakabayashi K, et al. Comprehensive analyses of imprinted differentially methylated regions reveal epigenetic and genetic characteristics in hepatoblastoma. BMC Cancer. 2013;13:608 pubmed publisher
    ..5 has been reported in many tumors including hepatoblastoma. However, the methylation status of imprinted DMRs in imprinted loci scattered through the human genome has ..
  8. Ward S, Thung S, Lim K, Tran T, Hong T, Hoang P, et al. Hepatic progenitor cells in liver cancers from Asian children. Liver Int. 2010;30:102-11 pubmed publisher
    b>Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the two most common primary malignant liver tumours in children. Hepatic progenitor cells have been described and can be stained with K19, EpCAM and CD117...
  9. Venturelli S, Berger A, Böcker A, Busch C, Weiland T, Noor S, et al. Resveratrol as a pan-HDAC inhibitor alters the acetylation status of histone [corrected] proteins in human-derived hepatoblastoma cells. PLoS ONE. 2013;8:e73097 pubmed publisher
    ..Moreover, resveratrol may serve as a lead structure for chemical optimization of bioavailability, pharmacology or HDAC inhibition. ..
  10. Till H, Metzger R, Bergmann F, Haeberle B, Schaeffer K, von Schweinitz D, et al. Tumor model for laparoscopy in pediatric oncology: subperitoneal inoculation of human hepatoblastoma cells in nude rats. Eur J Pediatr Surg. 2006;16:231-4 pubmed
    ..Especially for hepatoblastoma (HB), no study on the influence of laparoscopy is available yet...
  11. Corbin I, Li H, Chen J, Lund Katz S, Zhou R, Glickson J, et al. Low-density lipoprotein nanoparticles as magnetic resonance imaging contrast agents. Neoplasia. 2006;8:488-98 pubmed
    ..LDLs exhibited significant contrast enhancement 24 hours after administration in nude mice with human hepatoblastoma G2 xenografts...
  12. Zhang J, Cheng C, He C, Zhou Y, Cao Y. The expression of Bcl-XL, Bcl-XS and p27Kip1 in topotecan-induced apoptosis in hepatoblastoma HepG2 cell line. Cancer Invest. 2008;26:456-63 pubmed publisher
    ..and cytotoxicity as well as related proteins expression, had been preliminarily investigated in human hepatoblastoma HepG2 cells...
  13. Sakamoto L, de Camargo B, Cajaiba M, Soares F, Vettore A. MT1G hypermethylation: a potential prognostic marker for hepatoblastoma. Pediatr Res. 2010;67:387-93 pubmed publisher
    b>Hepatoblastoma comprises only 1% of all cancers in childhood. Because of its low frequency, a small number of prognostic factors are described in hepatoblastoma and most of them are related to resectability...
  14. Eicher C, Dewerth A, Kirchner B, Warmann S, Fuchs J, Armeanu Ebinger S. Treatment effects of the multikinase inhibitor sorafenib on hepatoblastoma cell lines and xenografts in NMRI-Foxn1 nu mice. Liver Int. 2012;32:574-81 pubmed publisher
    Multidrug resistance is a major reason for poor treatment results in advanced hepatoblastoma (HB)...
  15. Lee C, Zhang L, Mounajjed T, Wu T. High mobility group AT-hook 2 is overexpressed in hepatoblastoma. Hum Pathol. 2013;44:802-10 pubmed publisher
    b>Hepatoblastoma is the most frequent malignant hepatic tumor in children...
  16. Eichenmüller M, Gruner I, Hagl B, Häberle B, Müller Höcker J, Von Schweinitz D, et al. Blocking the hedgehog pathway inhibits hepatoblastoma growth. Hepatology. 2009;49:482-90 pubmed publisher
    ..In this study, we show that Hh signaling is activated in hepatoblastoma (HB), the most common liver tumor in childhood, with most occurrences before the age of 3 years...
  17. Neuwelt A, Wu Y, Knap N, Losin M, Neuwelt E, Pagel M, et al. Using acetaminophen's toxicity mechanism to enhance cisplatin efficacy in hepatocarcinoma and hepatoblastoma cell lines. Neoplasia. 2009;11:1003-11 pubmed
    ..of this study was to investigate whether acetaminophen (AAP) can enhance cisplatin (CDDP) cytotoxicity against human hepatocarcinoma and hepatoblastoma cells in vitro and whether this effect can be prevented by N-acetylcysteine (NAC).
  18. Guo R, Wang T, Shen H, Ge H, Sun J, Huang Z, et al. Involvement of mTOR and survivin inhibition in tamoxifen-induced apoptosis in human hepatoblastoma cell line HepG2. Biomed Pharmacother. 2010;64:249-53 pubmed publisher
    ..Our results suggest that tamoxifen down-regulate survivin expression in HepG2 cells is mediated by transcriptional and posttranscriptional level via PI3K/Akt/mTOR pathway to induce apoptosis...
  19. Yun W, Shin E, Lee K, Jung H, Kim S, Park Y, et al. Clinicopathologic implication of hepatic progenitor cell marker expression in hepatoblastoma. Pathol Res Pract. 2013;209:568-73 pubmed publisher
    Hepatic progenitor cells (HPCs) are thought to play a role in hepatoblastoma, as hepatoblastomas are characterized by an immature histology and a wide variety of cell lineages...
  20. Hou J, Liu H, Yeh T, Chen S, Wang L, Sheu J, et al. Long-term treatment results of hepatoblastoma at a single institution in Taiwan. J Pediatr Hematol Oncol. 2009;31:718-22 pubmed publisher
    From 1990 to 2004, there were 23 consecutive patients with hepatoblastoma treated at Mackay Memorial Hospital in Taipei, Taiwan. There were 7 patients of stage I, 3 of stage II, 13 of stage III, and none had stage IV disease...
  21. Lieber J, Kirchner B, Eicher C, Warmann S, Seitz G, Fuchs J, et al. Inhibition of Bcl-2 and Bcl-X enhances chemotherapy sensitivity in hepatoblastoma cells. Pediatr Blood Cancer. 2010;55:1089-95 pubmed publisher
    ..In Hepatoblastoma (HB) apoptosis regulation contributes to resistance and therapy failure, therefore we modulated apoptosis ..
  22. Hartmann W, Küchler J, Koch A, Friedrichs N, Waha A, Endl E, et al. Activation of phosphatidylinositol-3'-kinase/AKT signaling is essential in hepatoblastoma survival. Clin Cancer Res. 2009;15:4538-45 pubmed publisher
    b>Hepatoblastoma represents the most frequent malignant liver tumor in childhood...
  23. Eicher C, Dewerth A, Kirchner B, Warmann S, Fuchs J, Armeanu Ebinger S. Development of a drug resistance model for hepatoblastoma. Int J Oncol. 2011;38:447-54 pubmed publisher
    Multidrug resistance (MDR) is a major reason for poor treatment results in hepatoblastoma (HB). The objective of this study was to establish a drug resistance model for HB to analyse alternative treatment options in vitro...
  24. Trobaugh Lotrario A, Tomlinson G, Finegold M, Gore L, Feusner J. Small cell undifferentiated variant of hepatoblastoma: adverse clinical and molecular features similar to rhabdoid tumors. Pediatr Blood Cancer. 2009;52:328-34 pubmed publisher
    Small cell undifferentiated (SCU) histology in patients with stage I hepatoblastoma (HB) predicts an increased risk of relapse. We sought to determine the significance of SCU histology in patients with unresectable HB.
  25. Purcell R, Childs M, Maibach R, Miles C, Turner C, Zimmermann A, et al. HGF/c-Met related activation of ?-catenin in hepatoblastoma. J Exp Clin Cancer Res. 2011;30:96 pubmed publisher
    Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis...
  26. Malogolowkin M, Katzenstein H, Krailo M, Chen Z, Quinn J, Reynolds M, et al. Redefining the role of doxorubicin for the treatment of children with hepatoblastoma. J Clin Oncol. 2008;26:2379-83 pubmed publisher
    Systemic chemotherapy has improved the survival of patients with hepatoblastoma (HB)...
  27. Vogt F, Lieber J, Dewerth A, Hoh A, Fuchs J, Armeanu Ebinger S. BH3 mimetics reduce adhesion and migration of hepatoblastoma and hepatocellular carcinoma cells. Exp Cell Res. 2013;319:1443-50 pubmed publisher
    ..stages of tumour and development of metastases are the two major problems in treating liver tumours such as hepatoblastoma (HB) and hepatocellular carcinoma (HCC), in paediatric patients...
  28. Grotegut S, Kappler R, Tarimoradi S, Lehembre F, Christofori G, von Schweinitz D. Hepatocyte growth factor protects hepatoblastoma cells from chemotherapy-induced apoptosis by AKT activation. Int J Oncol. 2010;36:1261-7 pubmed
    ..In hepatoblastoma (HB), post-operative residual tumor growth and tumor recurrences are often associated with markedly elevated ..
  29. Oue T, Yoneda A, Uehara S, Yamanaka H, Fukuzawa M. Increased expression of the hedgehog signaling pathway in pediatric solid malignancies. J Pediatr Surg. 2010;45:387-92 pubmed publisher
    ..The present study was undertaken to examine the expression of the Hh signaling pathway in various pediatric tumors to elucidate the role of Hh signaling in pediatric malignancies...
  30. Bode H, Schimana W, Swai B, Bode U. Sexual precocity associated with an abdominal tumor in an African boy. J Pediatr Endocrinol Metab. 2008;21:275-7 pubmed
    We report a 3 year-old boy in Tanzania with an abdominal mass and isosexual precocity due to an hCG-secreting hepatoblastoma. Due to the limited availability of local diagnostic testing, surgery and chemotherapy were completed before ..
  31. Chen C, Tai C, Cheng J, Zheng J, Chen Y, Liu T, et al. 6-dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5. J Agric Food Chem. 2010;58:5604-11 pubmed publisher
    ..Zingiber officinale , and its mechanisms of sensitization to TRAIL-induced apoptosis were studied using human hepatoblastoma Hep G2 cells...
  32. Davenport K, Blanco F, Sandler A. Pediatric malignancies: neuroblastoma, Wilm's tumor, hepatoblastoma, rhabdomyosarcoma, and sacroccygeal teratoma. Surg Clin North Am. 2012;92:745-67, x pubmed publisher
    Common pediatric malignancies are reviewed: neuroblastoma, Wilms tumor, hepatoblastoma, rhabdomyosarcoma, and sacrococcygeal teratoma...
  33. McCarville M, Roebuck D. Diagnosis and staging of hepatoblastoma: imaging aspects. Pediatr Blood Cancer. 2012;59:793-9 pubmed publisher
    Imaging plays a pivotal role in the diagnosis and management of children with hepatoblastoma. However, the continuing evolution of imaging technologies and rarity of hepatoblastoma make validation of imaging approaches challenging...
  34. Gödeke J, Maier S, Eichenmüller M, Müller Höcker J, Von Schweinitz D, Kappler R. Epigallocatechin-3-gallate inhibits hepatoblastoma growth by reactivating the Wnt inhibitor SFRP1. Nutr Cancer. 2013;65:1200-7 pubmed publisher
    Activation of Wnt signaling plays a central role in the formation of hepatoblastoma (HB), the most common pediatric liver cancer. Blocking this pathway with specific inhibitors is currently the target of various research endeavours...
  35. Alshatwi A, Han C, Schoene N, Lei K. Nuclear accumulations of p53 and Mdm2 are accompanied by reductions in c-Abl and p300 in zinc-depleted human hepatoblastoma cells. Exp Biol Med (Maywood). 2006;231:611-8 pubmed
    ..known to be involved in the stability of p53, the human tumor suppressor gene product, was examined in hepatoblastoma (HepG2) cells. Cells were cultured in zinc-deficient (ZD0.2, ZD0...
  36. Arai Y, Honda S, Haruta M, Kasai F, Fujiwara Y, Ohshima J, et al. Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma. Genes Chromosomes Cancer. 2010;49:596-609 pubmed publisher
    In a single-nucleotide polymorphism array-based analysis of 56 hepatoblastoma (HB) tumors, allelic imbalances were detected in 37 tumors (66%)...
  37. Aktas S, Zadeoglulari Z, Erçetin P, Olgun N. The effect of differentiating and apoptotic agents on notch signalling pathway in hepatoblastoma. Hepatogastroenterology. 2010;57:891-8 pubmed
    Notch expression is not yet determined in hepatoblastoma. In this study the effect of chemotherapeutics (cisplatin, doxorubicin, cytosin arabinoside); differentiating agent (13 cis-retinoic acid) and apoptotic agents (5-aza-2'-..
  38. Turato C, Buendia M, Fabre M, Redon M, Branchereau S, Quarta S, et al. Over-expression of SERPINB3 in hepatoblastoma: a possible insight into the genesis of this tumour?. Eur J Cancer. 2012;48:1219-26 pubmed publisher
    ..No information is available on SB3 in hepatoblastoma (HB)...
  39. Masotti A, Vicennati P, Alisi A, Marianecci C, Rinaldi F, Carafa M, et al. Novel Tween 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma. Bioorg Med Chem Lett. 2010;20:3021-5 pubmed publisher
    ..These derivatives form pH-sensitive vesicles and translocate small molecules into cells. The reported systems are efficient drug delivery systems for human hepatoblastoma cells.
  40. Morita A, Tanimoto K, Murakami T, Morinaga T, Hosoi Y. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells. Biochem Biophys Res Commun. 2014;443:1286-90 pubmed publisher
    ..These findings strongly suggest that ATM can be activated in response to oxidative stress in mitochondria and that this occurs in a DDR-independent manner. ..
  41. Bercovitz R, Greffe B, Hunger S. Acute tumor lysis syndrome in a 7-month-old with hepatoblastoma. Curr Opin Pediatr. 2010;22:113-6 pubmed publisher
  42. Spector L, Johnson K, Soler J, Puumala S. Perinatal risk factors for hepatoblastoma. Br J Cancer. 2008;98:1570-3 pubmed publisher
    We confirmed the strong association of hepatoblastoma with very low birth weight (relative risk <1000 g vs >or=2000 g=25.6; 95% confidence interval: 7.70-85...
  43. Litten J, Tomlinson G. Liver tumors in children. Oncologist. 2008;13:812-20 pubmed publisher
    ..S. annually. The embryonal tumor, hepatoblastoma, accounts for two thirds of malignant liver tumors in children...
  44. Zynger D, Gupta A, Luan C, Chou P, Yang G, Yang X. Expression of glypican 3 in hepatoblastoma: an immunohistochemical study of 65 cases. Hum Pathol. 2008;39:224-30 pubmed
    ..developmental abnormalities, tissue overgrowth, and an increased risk for embryonal malignancies, including hepatoblastoma. GPC3 has been detected in hepatic stem cells and was recently identified as one of the most overexpressed ..
  45. Browne M, Sher D, Grant D, Deluca E, Alonso E, Whitington P, et al. Survival after liver transplantation for hepatoblastoma: a 2-center experience. J Pediatr Surg. 2008;43:1973-81 pubmed publisher
    Complete resection with adjuvant chemotherapy is the accepted treatment for hepatoblastoma. The aim of this study is to evaluate our results of liver transplantation (LT) for tumors still unresectable after adequate chemotherapy.
  46. Lieber J, Ellerkamp V, Wenz J, Kirchner B, Warmann S, Fuchs J, et al. Apoptosis sensitizers enhance cytotoxicity in hepatoblastoma cells. Pediatr Surg Int. 2012;28:149-59 pubmed publisher
    Drug resistance remains a major challenge for the treatment of high-risk hepatoblastoma (HB). To enhance effectiveness of chemotherapy we modulate apoptosis in HB cells in vitro.
  47. Malogolowkin M, Katzenstein H, Krailo M, Chen Z, Bowman L, Reynolds M, et al. Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma. J Clin Oncol. 2006;24:2879-84 pubmed
    ..Results from this and other therapeutic trials suggested that cisplatin was the most active agent against hepatoblastoma. To increase the platinum dose-intensity, a novel regimen was developed alternating carboplatin and cisplatin (..
  48. Schnater J, Bruder E, Bertschin S, Woodtli T, de Theije C, Pietsch T, et al. Subcutaneous and intrahepatic growth of human hepatoblastoma in immunodeficient mice. J Hepatol. 2006;45:377-86 pubmed
    b>Hepatoblastoma is the most frequent malignant pediatric liver tumor. Approximately 25% of hepatoblastoma patients cannot be cured with current treatment protocols. Additional treatment options must, therefore, be developed...
  49. Adesina A, Lopez Terrada D, Wong K, Gunaratne P, Nguyen Y, Pulliam J, et al. Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways. Hum Pathol. 2009;40:843-53 pubmed publisher
    b>Hepatoblastoma is the most common malignant tumor of the liver of children worldwide...
  50. Kopic S, Eirich K, Schuster B, Hanenberg H, Varon Mateeva R, Rittinger O, et al. Hepatoblastoma in a 4-year-old girl with Fanconi anaemia. Acta Paediatr. 2011;100:780-3 pubmed publisher
    b>Hepatoblastoma was diagnosed in a 4-year-old girl receiving growth hormone substitution therapy for short stature...
  51. Lopez Terrada D, Gunaratne P, Adesina A, Pulliam J, Hoang D, Nguyen Y, et al. Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors. Hum Pathol. 2009;40:783-94 pubmed publisher
    b>Hepatoblastoma is characterized by a diversity of differentiation patterns, some resembling stages of liver development, and occasionally associated with clinical behavior...
  52. Alisi A, Cho W, Locatelli F, Fruci D. Multidrug resistance and cancer stem cells in neuroblastoma and hepatoblastoma. Int J Mol Sci. 2013;14:24706-25 pubmed publisher
    ..on clinical as well as experimental evidence of the relations between CSCs and MDR in neuroblastoma and hepatoblastoma. Finally, some novel approaches, such as concomitant targeting of multiple key transcription factors governing ..
  53. Lovvorn H, Ayers D, Zhao Z, Hilmes M, Prasad P, Shinall M, et al. Defining hepatoblastoma responsiveness to induction therapy as measured by tumor volume and serum alpha-fetoprotein kinetics. J Pediatr Surg. 2010;45:121-8; discussion 129 pubmed publisher
    b>Hepatoblastoma is commonly unresectable at presentation, necessitating induction chemotherapy before definitive resection...
  54. Honda S, Haruta M, Sugawara W, Sasaki F, Ohira M, Matsunaga T, et al. The methylation status of RASSF1A promoter predicts responsiveness to chemotherapy and eventual cure in hepatoblastoma patients. Int J Cancer. 2008;123:1117-25 pubmed publisher
    Despite the progress of therapy, outcomes of advanced hepatoblastoma patients who are refractory to standard preoperative chemotherapy remain unsatisfactory...
  55. Sugawara W, Haruta M, Sasaki F, Watanabe N, Tsunematsu Y, Kikuta A, et al. Promoter hypermethylation of the RASSF1A gene predicts the poor outcome of patients with hepatoblastoma. Pediatr Blood Cancer. 2007;49:240-9 pubmed
    Despite the progress of therapy, about 25% of patients with hepatoblastoma succumb to the disease. Prognostic factors, as well as improved therapies, are needed for these patients...
  56. Ye J, Shu Q, Li M, Jiang T. Percutaneous radiofrequency ablation for treatment of hepatoblastoma recurrence. Pediatr Radiol. 2008;38:1021-3 pubmed publisher
    ..as a minimally invasive treatment for liver tumours in adults, but has not been documented as a treatment for hepatoblastoma in a child. We report a 2-year-old boy with local recurrence of hepatoblastoma after partial hepatectomy...
  57. Warmann S, Fuchs J. Drug resistance in hepatoblastoma. Curr Pharm Biotechnol. 2007;8:93-7 pubmed
    Treatment results of human hepatoblastoma (HB) have been improved remarkably during recent years, mainly through the establishment of integrated regimens controlled and coordinated by multicentric treatment studies...
  58. Tomizawa M, Saisho H. Signaling pathway of insulin-like growth factor-II as a target of molecular therapy for hepatoblastoma. World J Gastroenterol. 2006;12:6531-5 pubmed
    To address the possibility that insulin-like growth factor (IGF)-II is a growth factor and its signaling pathway so as to develop a molecular therapy for hepatoblastoma.
  59. Chitragar S, Iyer V, Agarwala S, Gupta S, Sharma A, Wari M. Loss of heterozygosity on chromosome 11p15.5 and relapse in hepatoblastomas. Eur J Pediatr Surg. 2011;21:50-3 pubmed publisher
    ..Earlier studies have not demonstrated any association between LOH and prognosis. Aim of the study was to evaluate the prognostic significance of LOH at 11p15.5 in hepatoblastomas...
  60. Meyers R, Rowland J, Krailo M, Chen Z, Katzenstein H, Malogolowkin M. Predictive power of pretreatment prognostic factors in children with hepatoblastoma: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2009;53:1016-22 pubmed publisher
    PRETEXT is used to stratify risk in children with hepatoblastoma by the Liver Tumor Strategy Group (SIOPEL) of the International Society of Pediatric Oncology (SIOP)...
  61. Hayashi S, Fujita K, Matsumoto S, Akita M, Satomi A. Isolation and identification of cancer stem cells from a side population of a human hepatoblastoma cell line, HuH-6 clone-5. Pediatr Surg Int. 2011;27:9-16 pubmed publisher
    ..If an alternative method of annihilating CSCs is found, it will greatly deter relapse and metastasis. We attempted to identify and separate CSCs in hepatoblastoma aiming to develop a new therapy for hepatoblastoma.
  62. Hishiki T, Matsunaga T, Sasaki F, Yano M, Ida K, Horie H, et al. Outcome of hepatoblastomas treated using the Japanese Study Group for Pediatric Liver Tumor (JPLT) protocol-2: report from the JPLT. Pediatr Surg Int. 2011;27:1-8 pubmed publisher
    ..surgical resection with pre- and/or postoperative chemotherapy has markedly improved the survival rate of hepatoblastoma patients...
  63. Armengol C, Cairo S, Fabre M, Buendia M. Wnt signaling and hepatocarcinogenesis: the hepatoblastoma model. Int J Biochem Cell Biol. 2011;43:265-70 pubmed publisher
    ..Among human cancers tightly linked to abnormal Wnt/?-catenin signaling, hepatoblastoma (HB) presents with the highest rate (50-90%) of ?-catenin mutations...
  64. Tomizawa M, Saisho H. Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines. J Cell Biochem. 2007;102:161-70 pubmed
    ..binding protein alpha (C/EBPalpha) in hepatocyte differentiation, we used Huh-6 and HepG2, human hepatoblastoma (HBL) cell lines that maintain the expression of genes in hepatoblasts and remain at that stage of ..
  65. Cai D, Jin H, Xiong Q, Liu W, Gao Z, Gu G, et al. ER stress and ASK1-JNK activation contribute to oridonin-induced apoptosis and growth inhibition in cultured human hepatoblastoma HuH-6 cells. Mol Cell Biochem. 2013;379:161-9 pubmed publisher
    ..The aims of the current study were to explore the anticancer abilities of oridonin in hepatoblastoma (HB) HuH-6 cells and to investigate the underlying mechanisms...
  66. Honda S, Arai Y, Haruta M, Sasaki F, Ohira M, Yamaoka H, et al. Loss of imprinting of IGF2 correlates with hypermethylation of the H19 differentially methylated region in hepatoblastoma. Br J Cancer. 2008;99:1891-9 pubmed publisher
    IGF2, a maternally imprinted foetal growth factor gene, is implicated in many childhood tumours including hepatoblastoma (HB); however, the genetic and epigenetic alterations have not comprehensively been studied...
  67. Lu M, Greer M. Hypervascular multifocal hepatoblastoma: dynamic gadolinium-enhanced MRI findings indistinguishable from infantile hemangioendothelioma. Pediatr Radiol. 2007;37:587-91 pubmed
    In this case report we describe a neonate with multifocal hypervascular hepatoblastoma indistinguishable from infantile hemangioendothelioma on dynamic gadolinium-enhanced MRI...
  68. Zhang S, Wang W, Cai W, Jiang K, Yuan Z. Engineered measles virus Edmonston strain used as a novel oncolytic viral system against human hepatoblastoma. BMC Cancer. 2012;12:427 pubmed publisher
    b>Hepatoblastoma (HB) is the most common primary, malignant pediatric liver tumor in children. The treatment results for affected children have markedly improved in recent decades...
  69. Trobaugh Lotrario A, Katzenstein H. Chemotherapeutic approaches for newly diagnosed hepatoblastoma: past, present, and future strategies. Pediatr Blood Cancer. 2012;59:809-12 pubmed publisher
    Surgical resection is the foundation of therapy in hepatoblastoma (HB), yet most patients have unresectable tumors at diagnosis...
  70. Parikh B, Jojo A, Shah B, Bansal R, Trivedi P, Shah M. Fine needle aspiration cytology of hepatoblastoma: a study of 20 cases. Indian J Pathol Microbiol. 2005;48:331-6 pubmed
    b>Hepatoblastoma (HBL) is the most common primary malignant hepatic tumor in children. The aim of the present study is to describe cytological findings of HBL, to subclassify it, and to discuss differential diagnoses...
  71. Halasz J, Holczbauer A, Páska C, Kovacs M, Benyó G, Verebely T, et al. Claudin-1 and claudin-2 differentiate fetal and embryonal components in human hepatoblastoma. Hum Pathol. 2006;37:555-61 pubmed
    ..The more aggressive, rapidly proliferating embryonal phenotype is associated with the decrease/loss of CLDN-1 and -2. However, there are no data indicating association with the nuclear translocation of beta-catenin...
  72. Clarke C, Baghdadi H, Howie A, Mason J, Walker S, Beckett G. Selenium supplementation attenuates procollagen-1 and interleukin-8 production in fat-loaded human C3A hepatoblastoma cells treated with TGFbeta1. Biochim Biophys Acta. 2010;1800:611-8 pubmed publisher
    ..The contributions of individual liver cell types to fibrogenesis remain controversial and the influence of selenium status has not been investigated...
  73. Von Schweinitz D. Hepatoblastoma: recent developments in research and treatment. Semin Pediatr Surg. 2012;21:21-30 pubmed publisher
    b>Hepatoblastoma is the most common liver tumor of early childhood. According to recent studies its incidence seems to be increasing in North America and Europe...
  74. Al Qubaisi M, Rozita R, Yeap S, Omar A, Ali A, Alitheen N. Selective cytotoxicity of goniothalamin against hepatoblastoma HepG2 cells. Molecules. 2011;16:2944-59 pubmed publisher
    ..The purpose of this study was to examine the in vitro cytotoxicity of goniothalamin on human hepatoblastoma HepG2 cells and normal liver Chang cells...
  75. Schmidt A, Braeuning A, Ruck P, Seitz G, Armeanu Ebinger S, Fuchs J, et al. Differential expression of glutamine synthetase and cytochrome P450 isoforms in human hepatoblastoma. Toxicology. 2011;281:7-14 pubmed publisher
    ..Activating CTNNB1 mutations were frequent in hepatoblastoma (80%) and nephroblastoma (31%)...
  76. Eichenmüller M, von Schweinitz D, Kappler R. Betulinic acid treatment promotes apoptosis in hepatoblastoma cells. Int J Oncol. 2009;35:873-9 pubmed
    b>Hepatoblastoma (HB) represents the most common malignant liver tumor in children with a dismal prognosis for patients with advanced disease...
  77. Grunewald T, von Luettichau I, Welsch U, Dörr H, Höpner F, Kovacs K, et al. First report of ectopic ACTH syndrome and PTHrP-induced hypercalcemia due to a hepatoblastoma in a child. Eur J Endocrinol. 2010;162:813-8 pubmed publisher
    ..Only occasionally, endocrine-active tumors develop directly from hepatic tissue, and may lead to paraneoplastic syndromes (PNS). PNS mostly accompany malignancy of adulthood and are exceedingly rare in children...
  78. Chopra A, Iyer V, Agarwala S, Mathur S, Aron M, Gupta S, et al. Apoptotic protein expression, glycogen content, DNA ploidy and cell proliferation in hepatoblastoma subtyping and their role in prognostication. Pediatr Surg Int. 2010;26:1173-8 pubmed publisher
    To evaluate Bcl-xL, Bax, PCNA, cytokeratin 19 (CK-19), glycogen content and DNA ploidy expression in hepatoblastoma (HB) and their prognostic value.