endometrial stromal sarcoma

Summary

Summary: A highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).

Top Publications

  1. Burke C, Hickey K. Treatment of endometrial stromal sarcoma with a gonadotropin-releasing hormone analogue. Obstet Gynecol. 2004;104:1182-4 pubmed
    b>Endometrial stromal sarcoma can present management difficulties due to its lack of response to conventional chemotherapy and radiotherapy...
  2. Al Salam S, El Terifi H, Ghazal Aswad S. Low-grade endometrial stromal sarcoma with sex cord-like differentiation metastatic to the thoracic spines. APMIS. 2006;114:651-5 pubmed
    ..A 48-year-old female who had undergone total abdominal hysterectomy for low-grade endometrial stromal sarcoma 7 years previously presented with insidious onset of severe back pain of 2 months' duration...
  3. Reich O, Regauer S. Hormonal therapy of endometrial stromal sarcoma. Curr Opin Oncol. 2007;19:347-52 pubmed
    ..Low-grade endometrial stromal sarcomas are steroid receptor positive tumors with slow tumor progression and high recurrence rates, which lack established treatment protocols. We present an update on hormonal therapy options...
  4. Gupta N, Awasthi A, Rajwanshi A, Sarla M. Fine needle aspiration cytology of low grade endometrial stromal sarcoma: a case report. Acta Cytol. 2007;51:461-3 pubmed
    b>Endometrial stromal sarcoma (ESS) is a rare neoplasm and is composed of E cells closely resembling normal proliferative endometrial stromal cells. Because of its rarity, the preoperative diagnosis is difficult for clinicians...
  5. Ihnen M, Mahner S, Janicke F, Schwarz J. Current treatment options in uterine endometrial stromal sarcoma: report of a case and review of the literature. Int J Gynecol Cancer. 2007;17:957-63 pubmed
    ..b>Endometrial stromal sarcoma (ESS) accounts for 0.2% of all gynecological malignancies...
  6. Ali R, El Hady E, El Zayat M. Multilocular intrauterine cystic mass, atypical presentation of endometrial stromal sarcoma: a case report. Arch Gynecol Obstet. 2008;277:185-7 pubmed
    b>Endometrial stromal sarcoma (ESS) is a rare neoplasm comprising only 0.2% of all uterine malignancies and 15-26% of primary uterine sarcomas...
  7. Perez Montiel D, Salmeron A, Dominguez Malagon H. Multicystic endometrial stromal sarcoma. Ann Diagn Pathol. 2004;8:213-8 pubmed
    b>Endometrial stromal sarcoma usually has the gross appearance of a single nodule, multiple masses, or a poorly demarcated lesion with occasional cystic degeneration; however, a multilocular form has not been described in the literature...
  8. Ramondetta L, Johnson A, Sun C, Atkinson N, Smith J, Jung M, et al. Phase 2 trial of mifepristone (RU-486) in advanced or recurrent endometrioid adenocarcinoma or low-grade endometrial stromal sarcoma. Cancer. 2009;115:1867-74 pubmed publisher
    ..of mifepristone (RU-486) in women with advanced or recurrent endometrioid adenocarcinoma or low-grade endometrial stromal sarcoma (LGESS)...
  9. Bodner K, Bodner Adler B, Obermair A, Windbichler G, Petru E, Mayerhofer S, et al. Prognostic parameters in endometrial stromal sarcoma: a clinicopathologic study in 31 patients. Gynecol Oncol. 2001;81:160-5 pubmed
    ..Thirty-one patients with histologically proven ESS were included in the analysis. Endometrial stromal sarcoma is characterized by proliferations composed of cells with endometrial stromal cell differentiation...

More Information

Publications74

  1. Balleine R, Earls P, Webster L, Mote P, deFazio A, Harnett P, et al. Expression of progesterone receptor A and B isoforms in low-grade endometrial stromal sarcoma. Int J Gynecol Pathol. 2004;23:138-44 pubmed
    ..Low-grade endometrial stromal sarcoma (LGESS) is an uncommon tumor that usually expresses PR...
  2. Zhu X, Shi Y, Cheng X, Zhao C, Wu Y. Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. Gynecol Oncol. 2004;92:71-9 pubmed
    Distinction of endometrial stromal sarcoma (ESS) from benign smooth muscle proliferations like cellular leiomyoma (CL) is sometimes problematic...
  3. Spano J, Soria J, Kambouchner M, Piperno Neuman S, Morin F, Morere J, et al. Long-term survival of patients given hormonal therapy for metastatic endometrial stromal sarcoma. Med Oncol. 2003;20:87-93 pubmed
    b>Endometrial stromal sarcoma (ESS) is a rare neoplasm, mainly observed in premenopausal women...
  4. Amant F, Moerman P, Cadron I, Neven P, Berteloot P, Vergote I. The diagnostic problem of endometrial stromal sarcoma: report on six cases. Gynecol Oncol. 2003;90:37-43 pubmed
    ..was to look for the incidence and clinicopathologic findings of women in whom the diagnosis of endometrial stromal sarcoma was initially missed...
  5. Amant F, Vergote I, Moerman P. The classification of a uterine sarcoma as 'high-grade endometrial stromal sarcoma' should be abandoned. Gynecol Oncol. 2004;95:412-3; author reply 413 pubmed
  6. Micci F, Panagopoulos I, Bjerkehagen B, Heim S. Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Cancer Res. 2006;66:107-12 pubmed
    ..The PHF1 gene encodes a protein with two zinc finger motifs whose involvement in tumorigenesis and/or tumor progression has not been reported before, but its rearrangement clearly defines a new pathogenetic subgroup of ESS. ..
  7. Reed N, Mangioni C, Malmstrom H, Scarfone G, Poveda A, Pecorelli S, et al. Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874). Eur J Cancer. 2008;44:808-18 pubmed publisher
    ..CS appears to show more kinship to poorly differentiated endometrial carcinomas in behaviour. LMS did not show the same benefit from radiation. These results will help shape future management and clinical trials in uterine sarcomas...
  8. Leunen M, Breugelmans M, De Sutter P, Bourgain C, Amy J. Low-grade endometrial stromal sarcoma treated with the aromatase inhibitor letrozole. Gynecol Oncol. 2004;95:769-71 pubmed
    Low-grade endometrial stromal sarcoma is an indolent steroid responsive tumor. Successful hormonal treatment, most commonly with megestrol acetate, has been reported.
  9. Renzulli P, Weimann R, Barras J, Carrel T, Candinas D. Low-grade endometrial stromal sarcoma with inferior vena cava tumor thrombus and intracardiac extension: radical resection may improve recurrence free survival. Surg Oncol. 2009;18:57-64 pubmed publisher
    b>Endometrial stromal sarcoma (ESS) represents 0.2% of all uterine malignancies. Based on the mitotic activity, a distinction is made between low and high-grade ESS...
  10. Leunen K, Amant F, Debiec Rychter M, Croes R, Hagemeijer A, Schoenmakers E, et al. Endometrial stromal sarcoma presenting as postpartum haemorrhage: report of a case with a sole t(10;17)(q22;p13) translocation. Gynecol Oncol. 2003;91:265-71 pubmed
    Although the clinical picture of endometrial stromal sarcoma (ESS) is variable, it was never reported to present as a postpartum hemorrhage...
  11. Stadsvold J, Molpus K, Baker J, Michael K, Remmenga S. Conservative management of a myxoid endometrial stromal sarcoma in a 16-year-old nulliparous woman. Gynecol Oncol. 2005;99:243-5 pubmed
    ..comprise less than 1% of all gynecological cancers and 2% to 5% of all uterine malignancies, of which endometrial stromal sarcoma accounts for approximately 15%...
  12. Sandberg A. The cytogenetics and molecular biology of endometrial stromal sarcoma. Cytogenet Genome Res. 2007;118:182-9 pubmed
  13. Kusaka M, Mikuni M, Nishiya M. A case of high-grade endometrial stromal sarcoma arising from endometriosis in the cul-de-sac. Int J Gynecol Cancer. 2006;16:895-9 pubmed
    This report describes a rare case of high-grade endometrial stromal sarcoma (ESS) arising from pathologically confirmed endometriosis in the cul-de-sac. A 37-year-old woman presented with irregular menstruation, pelvic pain, and diarrhea...
  14. Chu P, Arber D, Weiss L, Chang K. Utility of CD10 in distinguishing between endometrial stromal sarcoma and uterine smooth muscle tumors: an immunohistochemical comparison of 34 cases. Mod Pathol. 2001;14:465-71 pubmed
    b>Endometrial stromal sarcoma (ESS), uterine cellular leiomyoma (UCL), and uterine leiomyosarcoma (ULS) are composed mainly of spindle cells that express similar antigens such as desmin, smooth muscle actin (SMA), and muscle-specific actin ..
  15. Amant F, Moerman P, Cadron I, Hagemeijer A, Vergote I, Debiec Rychter M. Endometrial stromal sarcoma with a sole t(X;17) chromosome change: report of a case and review of the literature. Gynecol Oncol. 2003;88:459-62 pubmed
    ..Endometrial stromal sarcomas (ESSs) exhibit varying degrees of malignancy and heterogeneity at the karyotypic level. The biological mechanisms that contribute to tumorigenesis of ESS are still largely unknown...
  16. Kir G, Cetiner H, Karateke A, Gurbuz A, Bulbul D. Utility of MIB-1 and estrogen and progesterone receptor in distinguishing between endometrial stromal sarcomas and endometrial stromal nodules, highly cellular leiomyomas. Int J Gynecol Cancer. 2005;15:337-42 pubmed
    It is difficult to differentiate between an endometrial stromal nodule (ESN) and endometrial stromal sarcoma (ESS) in curettage specimen, and the recommended therapy of endometrial stromal neoplasm is hysterectomy...
  17. Akahira J, Tokunaga H, Toyoshima M, Takano T, Nagase S, Yoshinaga K, et al. Prognoses and prognostic factors of carcinosarcoma, endometrial stromal sarcoma and uterine leiomyosarcoma: a comparison with uterine endometrial adenocarcinoma. Oncology. 2006;71:333-40 pubmed
  18. Leiser A, Hamid A, Blanchard R. Recurrence of prolactin-producing endometrial stromal sarcoma with sex-cord stromal component treated with progestin and aromatase inhibitor. Gynecol Oncol. 2004;94:567-71 pubmed
    ..We report a case of this neoplasm with prolactin as a tumor marker for recurrent disease. We also report response of recurrent disease to progesterone and aromatase inhibitor...
  19. Agoff S, Grieco V, Garcia R, Gown A. Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma. Appl Immunohistochem Mol Morphol. 2001;9:164-9 pubmed
    Distinguishing low grade endometrial stromal sarcoma (ESS) from benign smooth muscle proliferations like cellular leiomyoma (CL) can be problematic; because of differing treatments and prognosis, this distinction is important...
  20. Diesing D, Cordes T, Finas D, Löning M, Mayer K, Diedrich K, et al. Endometrial stromal sarcomas--a retrospective analysis of 11 patients. Anticancer Res. 2006;26:655-61 pubmed
    b>Endometrial stromal sarcoma (ESS) is a malignant tumour with its origin in the endometrial stroma. Little is known about the pathogenesis, risk factors, optimal therapy or outcome of this disease.
  21. Reich O, Regauer S. Estrogen replacement therapy and tamoxifen are contraindicated in patients with endometrial stromal sarcoma. Gynecol Oncol. 2006;102:413-4; author reply 414 pubmed
  22. Sesti F, Patrizi L, Ermini B, Palmieri G, Orlandi A, Piccione E. High-grade endometrial stromal sarcoma after tamoxifen therapy for breast cancer. Gynecol Obstet Invest. 2005;60:117-20 pubmed
    A case of high-grade endometrial stromal sarcoma, confined into an intrauterine polypoid growth, in a woman with a history of breast cancer who was treated with adjuvant tamoxifen...
  23. Yokoyama Y, Ono Y, Sakamoto T, Fukuda I, Mizunuma H. Asymptomatic intracardiac metastasis from a low-grade endometrial stromal sarcoma with successful surgical resection. Gynecol Oncol. 2004;92:999-1001 pubmed
    The endometrial stromal sarcoma (ESS) is a rare neoplasm of the uterine origin. Intracardiac metastasis from the low-grade ESS is an extremely rare event...
  24. Kakuno Y, Yamada T, Mori H, Narabayashi I. Establishment and characterization of a cell line (OMC-9) originating from a human endometrial stromal sarcoma. Hum Cell. 2008;21:46-55 pubmed publisher
    ..We describe the establishment and characterization of a new human endometrial stromal sarcoma cell line of the uterus...
  25. Aubry M, Myers J, Colby T, Leslie K, Tazelaar H. Endometrial stromal sarcoma metastatic to the lung: a detailed analysis of 16 patients. Am J Surg Pathol. 2002;26:440-9 pubmed
    Pulmonary metastases of endometrial stromal sarcoma (ESS) are uncommon and can pose diagnostic problems. We reviewed lung specimens from 16 patients with metastatic ESS. Patients were 31-77 years of age at the time of lung biopsy...
  26. Micci F, Heim S. Pathogenetic mechanisms in endometrial stromal sarcoma. Cytogenet Genome Res. 2007;118:190-5 pubmed
  27. Reich O, Regauer S, Urdl W, Lahousen M, Winter R. Expression of oestrogen and progesterone receptors in low-grade endometrial stromal sarcomas. Br J Cancer. 2000;82:1030-4 pubmed
    ..This may have implications for hormone therapy in the management of these tumours. These results suggest that ER and PR should be routinely quantified in LGSSs by immunohistochemical methods...
  28. Brooks S, Zhan M, Cote T, Baquet C. Surveillance, epidemiology, and end results analysis of 2677 cases of uterine sarcoma 1989-1999. Gynecol Oncol. 2004;93:204-8 pubmed
    ..To determine the association of race with incidence, histology, treatment, and survival in women with uterine sarcoma during the period 1989-1999...
  29. Alkasi O, Meinhold Heerlein I, Zaki R, Fasching P, Maass N, Jonat W, et al. Long-term disease-free survival after hormonal therapy of a patient with recurrent low grade endometrial stromal sarcoma: a case report. Arch Gynecol Obstet. 2009;279:57-60 pubmed publisher
    Approximately 50% of patients with low-grade endometrial stromal sarcoma (ESS) develop recurrent disease including mainly metastases of pelvis and lung. A solitary pulmonary metastasis of this disease is a rare phenomenon.
  30. Mourra N, Tiret E, Parc Y, De Saint Maur P, Parc R, Flejou J. Endometrial stromal sarcoma of the rectosigmoid colon arising in extragonadal endometriosis and revealed by portal vein thrombosis. Arch Pathol Lab Med. 2001;125:1088-90 pubmed
    ..We report a case of low-grade endometrial stromal sarcoma of the rectosigmoid colon presenting with epigastric pain due to portal vein thrombosis...
  31. Koskas M, Morice P, Yazbeck C, Duvillard P, Walker F, Madelenat P. Conservative management of low-grade endometrial stromal sarcoma followed by pregnancy and severe recurrence. Anticancer Res. 2009;29:4147-50 pubmed
    Since low-grade endometrial stromal sarcoma (LGESS) has the most favourable prognosis in comparison to other sarcomas, fertility-sparing surgery in young women has been reported in rare cases...
  32. Policarpio Nicolas M, Cathro H, Kerr S, Stelow E. Cytomorphologic features of low-grade endometrial stromal sarcoma. Am J Clin Pathol. 2007;128:265-71 pubmed
    ..The cells were predominantly spindle shaped with scant to moderate cytoplasm, round to ovoid nuclei, and fine chromatin. Mitotic figures and nucleoli were rare. Most cases had a clean background...
  33. Denschlag D, Masoud I, Stanimir G, Gilbert L. Prognostic factors and outcome in women with uterine sarcoma. Eur J Surg Oncol. 2007;33:91-5 pubmed
    ..A retrospective analysis of patients with uterine sarcoma was undertaken to assess prognostic factors and treatment related outcomes...
  34. Klaritsch P, Reich O, Regauer S, Bauernhofer T. Recurrent endometrial stromal sarcoma after treatment with high-dose chemotherapy and autologous stem-cell support: A case report. Eur J Gynaecol Oncol. 2006;27:297-8 pubmed
    ..The efficacy of high-dose chemotherapy plus transplantation of autologous hematopoetic stem cells in patients with endometrial stromal sarcomas is unknown...
  35. Maluf F, Sabbatini P, Schwartz L, Xia J, Aghajanian C. Endometrial stromal sarcoma: objective response to letrozole. Gynecol Oncol. 2001;82:384-8 pubmed
    Low-grade endometrial stromal sarcoma is generally an indolent tumor rich in estrogen and progesterone receptors. Objective responses to hormonal therapy, most commonly with megestrol acetate, have been reported.
  36. Cho H, Kim M, Cho S, Bae J, Kim I. Endometrial stromal sarcoma of the sigmoid colon arising in endometriosis: a case report with a review of literatures. J Korean Med Sci. 2002;17:412-4 pubmed
    ..Mixed mullerian tumor and endometrial stromal sarcoma arising in intestinal endometriosis are rarely described, but its clinicopathologic features have not ..
  37. Corpa M, Serafini E, Bacchi C. Low-grade endometrial stromal sarcoma presenting as vaginal nodule. Ann Diagn Pathol. 2004;8:295-8 pubmed
    b>Endometrial stromal sarcoma is a rare neoplasm of the uterus. Extrauterine locations of this neoplasm, excluding metastases or local extension, are even more unusual and are usually associated with the presence of endometriosis...
  38. Kovac D, Gašparović I, Jasic M, Fuckar D, Dobi Babic R, Haller H. Endometrial stromal sarcoma arising in extrauterine endometriosis: a case report. Eur J Gynaecol Oncol. 2005;26:113-6 pubmed
    We report a rare case of a 46-year-old woman developing endometrial stromal sarcoma (ESS) on the grounds of extrauterine endometriosis. The patient presented with symptoms of stenosis of the rectosygmoid colon...
  39. Kim G, Sung C, Han J, Park J, Lee K. Pulmonary metastases of uterine endometrial stromal sarcoma: diffuse micronodular and ground glass opacities: a case report. J Korean Med Sci. 2004;19:901-3 pubmed
    Pulmonary metastases of uterine endometrial stromal sarcoma (ESS) are uncommon. The patterns of uterine ESS metastasis to the lung are multiple pulmonary nodules, single nodule, or cystic lesions...
  40. Yamada K, Kano J, Tsunoda H, Yoshikawa H, Okubo C, Ishiyama T, et al. Phenotypic characterization of endometrial stromal sarcoma of the uterus. Cancer Sci. 2006;97:106-12 pubmed
    b>Endometrial stromal sarcoma (ESS) of the uterus is a rare uterine malignancy that has not been characterized in detail...
  41. Weitmann H, Kucera H, Knocke T, Potter R. Surgery and adjuvant radiation therapy of endometrial stromal sarcoma. Wien Klin Wochenschr. 2002;114:44-9 pubmed
    In the treatment of endometrial stromal sarcoma, it is still not clear whether adjuvant radiation therapy improves the outcome...
  42. Chu M, Mor G, Lim C, Zheng W, Parkash V, Schwartz P. Low-grade endometrial stromal sarcoma: hormonal aspects. Gynecol Oncol. 2003;90:170-6 pubmed
    ..The goal of this work was to determine whether exposure to estrogen following treatment of low-grade endometrial stromal sarcomas affects clinical outcome...
  43. Chan J, Kawar N, Shin J, Osann K, Chen L, Powell C, et al. Endometrial stromal sarcoma: a population-based analysis. Br J Cancer. 2008;99:1210-5 pubmed publisher
    To determine independent prognostic factors for the survival of patients with endometrial stromal sarcoma (ESS), data were abstracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute ..
  44. Li N, Wu L, Zhang H, An J, Li X, Ma S. Treatment options in stage I endometrial stromal sarcoma: a retrospective analysis of 53 cases. Gynecol Oncol. 2008;108:306-11 pubmed
    To discuss the optimal treatment options for stage I patients with endometrial stromal sarcoma (ESS).
  45. Szlosarek P, Lofts F, Pettengell R, Carter P, Young M, Harmer C. Effective treatment of a patient with a high-grade endometrial stromal sarcoma with an accelerated regimen of carboplatin and paclitaxel. Anticancer Drugs. 2000;11:275-8 pubmed
    The rarity of endometrial stromal sarcoma (ESS) and its poor response to treatment provides fertile ground for investigational therapies. An accelerated regimen of carboplatin and paclitaxel is investigated...
  46. Valduvieco I, Rovirosa A, Colomo L, De San Juan A, Pahisa J, Biete A. Endometrial stromal sarcoma. Is there a place for radiotherapy?. Clin Transl Oncol. 2010;12:226-30 pubmed
    The optimal approach in the management of endometrial stromal sarcoma (ESS) remains unclear...
  47. Kim L, Choi S, Park I, Han J, Kim J, Chu Y, et al. Endometrial stromal sarcoma of the small bowel. Ann Diagn Pathol. 2008;12:128-33 pubmed publisher
    b>Endometrial stromal sarcoma (ESS) is a rare mesenchymal neoplasm of the uterus, which is predominantly composed of endometrial stromal cells...
  48. Li A, Giuntoli R, Drake R, Byun S, Rojas F, Barbuto D, et al. Ovarian preservation in stage I low-grade endometrial stromal sarcomas. Obstet Gynecol. 2005;106:1304-8 pubmed
    ..To examine the impact of ovarian preservation in a case-control study of women with stage I low-grade endometrial stromal sarcomas...
  49. Reich O, Winter R, Regauer S. Should lymphadenectomy be performed in patients with endometrial stromal sarcoma?. Gynecol Oncol. 2005;97:982; author reply 982-3 pubmed
  50. Matsuura Y, Yasunaga K, Kuroki H, Inagaki H, Kashimura M. Low-grade endometrial stromal sarcoma recurring with multiple bone and lung metastases: report of a case. Gynecol Oncol. 2004;92:995-8 pubmed
    Approximately 50% of patients with low-grade endometrial stromal sarcoma (ESS) develop recurrent disease, mainly in lung or pelvis. Bone metastasis of low-grade ESS is an extremely rare phenomenon.
  51. Saga Y, Ohwada M, Kohno T, Takayashiki N, Suzuki M. High-grade endometrial stromal sarcoma after treatment with tamoxifen in a patient treated for breast cancer. Int J Gynecol Cancer. 2003;13:690-2 pubmed
    ..Here we report a woman who developed a high-grade endometrial stromal sarcoma after receiving postmastectomy tamoxifen therapy...
  52. Leath C, Huh W, Hyde J, Cohn D, Resnick K, Taylor N, et al. A multi-institutional review of outcomes of endometrial stromal sarcoma. Gynecol Oncol. 2007;105:630-4 pubmed
    ..To compare the clinical behavior and outcomes of low- and high-grade endometrial stromal sarcomas (LGESS and HGESS), respectively...
  53. Amant F, De Knijf A, Van Calster B, Leunen K, Neven P, Berteloot P, et al. Clinical study investigating the role of lymphadenectomy, surgical castration and adjuvant hormonal treatment in endometrial stromal sarcoma. Br J Cancer. 2007;97:1194-9 pubmed
    ..the therapeutic importance of surgical castration, adjuvant hormonal treatment and lymphadenectomy in endometrial stromal sarcoma (ESS). A retrospective and multicentric search was performed...
  54. Levine P, Abou Nassar S, Mittal K. Extrauterine low-grade endometrial stromal sarcoma with florid endometrioid glandular differentiation. Int J Gynecol Pathol. 2001;20:395-8 pubmed
    b>Endometrial stromal sarcoma of the uterus (ESS) is a rare lesion that can cause diagnostic difficulty especially when it presents with unusual histologic features such as diffuse endometrioid glandular differentiation...
  55. Halbwedl I, Ullmann R, Kremser M, Man Y, Isadi Moud N, Lax S, et al. Chromosomal alterations in low-grade endometrial stromal sarcoma and undifferentiated endometrial sarcoma as detected by comparative genomic hybridization. Gynecol Oncol. 2005;97:582-7 pubmed
    ..The aim of the present study was to characterize the karyotypic abnormalities in these malignant mesenchymal tumors and to find specific chromosomal aberrations with eventual correlation with histologic grades...
  56. Lacroix Triki M, Beyris L, Martel P, Marques B. Low-grade endometrial stromal sarcoma arising from sciatic nerve endometriosis. Obstet Gynecol. 2004;104:1147-9 pubmed
    b>Endometrial stromal sarcoma arising from extrauterine endometriosis is a rare and not easily diagnosed tumor. We present a case arising from sciatic nerve endometriosis in a 50-year-old woman.
  57. Haberal A, Kayikcioglu F, Boran N, Caliskan E, Ozgul N, Kose M. Endometrial stromal sarcoma of the uterus: analysis of 25 patients. Eur J Obstet Gynecol Reprod Biol. 2003;109:209-13 pubmed
    To analyze the prognostic factors in endometrial stromal sarcoma (ESS).
  58. Berceanu S, Patrascu A, Berceanu C, Tica A, Bădulescu A. Endometrial stromal sarcoma: clinico-pathological report of four cases and review of the literature. Rom J Morphol Embryol. 2008;49:251-5 pubmed
    b>Endometrial stromal sarcoma (ESS) represents a very rare pathological entity occurring as a malignant disease in women genital sphere...
  59. Reed N. The management of uterine sarcomas. Clin Oncol (R Coll Radiol). 2008;20:470-8 pubmed publisher
    ..Given their relative uncommonness, centralisation of care and discussion at multi-disciplinary tumour boards is essential. International collaboration is essential...
  60. Ueda M, Otsuka M, Hatakenaka M, Sakai S, Ono M, Yoshimitsu K, et al. MR imaging findings of uterine endometrial stromal sarcoma: differentiation from endometrial carcinoma. Eur Radiol. 2001;11:28-33 pubmed
    b>Endometrial stromal sarcoma (ESS) is a rare malignant neoplasm of the uterus. We retrospectively analyzed pelvic MR imaging in 8 cases of ESS to determine the characteristic MR findings of ESS...
  61. Popiolek D, Yee H, Levine P, Vamvakas E, Demopoulos R. MIB1 as a possible predictor of recurrence in low-grade endometrial stromal sarcoma of the uterus. Gynecol Oncol. 2003;90:353-7 pubmed
    ..Since predictors of recurrence for low-grade endometrial stromal sarcoma (LESS) are still unknown, a battery of immunostains was performed to find markers, which might be ..
  62. Moinfar F, Regitnig P, Tabrizi A, Denk H, Tavassoli F. Expression of androgen receptors in benign and malignant endometrial stromal neoplasms. Virchows Arch. 2004;444:410-4 pubmed
    ..In addition to determination of ER and PR, the results of immunohistochemical examination of AR in these rare uterine tumors may have some impact on the postoperative management of the patients...
  63. Brunisholz Y, Miller J, Scurry J, Proietto A. Endometrial stromal sarcoma resembling adenomyosis and menstrual-phase endometrium. Gynecol Oncol. 2004;95:256-9 pubmed
    Low-grade endometrial stromal sarcoma (LGESS) and endometriosis are two conditions of different prognostic significance that are usually not difficult to distinguish histologically.
  64. Kanjeekal S, Chambers A, Fung M, Verma S. Systemic therapy for advanced uterine sarcoma: a systematic review of the literature. Gynecol Oncol. 2005;97:624-37 pubmed
    ..To conduct a systematic review of the literature regarding the systemic treatment of advanced uterine sarcoma and provide an evidence-based summary of the available literature...
  65. Liegl B, Reich O, Nogales F, Regauer S. PDGF-alpha and PDGF-beta are expressed in endometrial stromal sarcoma: a potential therapeutic target for tyrosine kinase inhibitors?. Histopathology. 2006;49:545-6 pubmed