carcinosarcoma

Summary

Summary: A malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. (Stedman, 25th ed)

Top Publications

  1. Bansal N, Herzog T, Seshan V, Schiff P, Burke W, Cohen C, et al. Uterine carcinosarcomas and grade 3 endometrioid cancers: evidence for distinct tumor behavior. Obstet Gynecol. 2008;112:64-70 pubmed publisher
    ..To compare the clinical behavior and outcome of uterine carcinosarcomas and grade 3 endometrioid carcinomas...
  2. Garg G, Shah J, Kumar S, Bryant C, Munkarah A, Morris R. Ovarian and uterine carcinosarcomas: a comparative analysis of prognostic variables and survival outcomes. Int J Gynecol Cancer. 2010;20:888-94 pubmed publisher
    ..The identified cohort included 3683 women of whom 2759 (75%) have uterine carcinosarcoma and 924 (25%) have ovarian carcinosarcomas...
  3. Chandiramani M, Joynson C, Panchal R, Symonds R, Brown L, Morgan B, et al. Dermatomyositis as a paraneoplastic syndrome in carcinosarcoma of uterine origin. Clin Oncol (R Coll Radiol). 2006;18:641-8 pubmed
    ..We present a case of a patient presenting simultaneously with an advanced carcinosarcoma of the uterus and dermatomyositis...
  4. Yoshino N, Kubokura H, Yamauchi S, Ohaki Y, Koizumi K, Shimizu K. A true pulmonary carcinosarcoma that required diagnostic differentiation from a pleomorphic adenoma: a case report. Ann Thorac Cardiovasc Surg. 2009;15:42-5 pubmed
    Pulmonary carcinosarcoma is a rarely encountered tumor...
  5. Vidal Losada M, Bernal Monterde V, Amores Arriaga B, Ferrer Pérez A, Serrano Solares S, Tobeña Puyal M. Lung carcinosarcoma. Clin Transl Oncol. 2010;12:303-5 pubmed publisher
    Lung carcinosarcoma is a neoplasm of high grade composed of epithelial and mesenchymal cells. It is exceptional; and usually affects men who are smokers, between the fifth and eighth decades of life...
  6. Damiano R, D Armiento M, Cantiello F, Amorosi A, Tagliaferri P, Sacco R, et al. Gemcitabine and cisplatin following surgical treatment of urinary bladder carcinosarcoma. Tumori. 2004;90:458-60 pubmed
    ..b>Carcinosarcoma is highly aggressive and often has a dismal outcome regardless of treatment...
  7. Weissferdt A, Moran C. Malignant biphasic tumors of the lungs. Adv Anat Pathol. 2011;18:179-89 pubmed publisher
    ..The tumors belonging to this group include pulmonary blastoma, pleuropulmonary blastoma, and carcinosarcoma. In this study, the clinicopathologic features, immunohistochemical phenotype, molecular biological ..
  8. Nemani D, Mitra N, Guo M, Lin L. Assessing the effects of lymphadenectomy and radiation therapy in patients with uterine carcinosarcoma: a SEER analysis. Gynecol Oncol. 2008;111:82-8 pubmed publisher
    ..of this analysis is to determine the pathologic prognostic factors and treatment outcome of patients with carcinosarcoma of the uterus...
  9. Pelosi G, Sonzogni A, De Pas T, Galetta D, Veronesi G, Spaggiari L, et al. Review article: pulmonary sarcomatoid carcinomas: a practical overview. Int J Surg Pathol. 2010;18:103-20 pubmed publisher
    ..of 5 major histological variants, namely pleomorphic carcinoma, spindle cell carcinoma, giant cell carcinoma, carcinosarcoma, and pulmonary blastoma...

More Information

Publications69

  1. George E, Herzog T, Neugut A, Lu Y, Burke W, Lewin S, et al. Carcinosarcoma of the ovary: natural history, patterns of treatment, and outcome. Gynecol Oncol. 2013;131:42-5 pubmed publisher
    ..Ovarian carcinosarcomas (OCS) are rare tumors composed of both malignant epithelial and mesenchymal elements. We compared the natural history and outcomes of OCS to serous carcinoma of the ovary...
  2. Chiu K, Lin M, Liang Y, Chen C. Renal carcinosarcoma: case report and review of literature. Ren Fail. 2008;30:1034-9 pubmed publisher
    b>Carcinosarcoma is a malignancy that occurs very rarely in the renal pelvis, and only a very limited number of cases has been documented. These tumors are composed of both malignant mesenchymal and epithelial elements...
  3. Suspitsin E, Sokolenko A, Voskresenskiy D, Ivantsov A, Shelehova K, Klimashevskiy V, et al. Mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma) of the breast in BRCA1 carrier. Breast Cancer. 2011;18:137-40 pubmed publisher
    ..describes a 35-year-old woman who was diagnosed with mixed epithelial/mesenchymal metaplastic carcinoma (carcinosarcoma) of the breast. Genetic analysis of blood DNA revealed a common founder mutation, BRCA1 5382insC...
  4. Kim H, Joo S, Yang D, Lee S, Choi S, Lim S. Carcinosarcoma of the pancreas: a unique case with emphasis on metaplastic transformation and the presence of undifferentiated pleomorphic high-grade sarcoma. J Gastrointestin Liver Dis. 2011;20:197-200 pubmed
    We report a rare case of pancreatic carcinosarcoma in a 48-year-old man. An abdominal ultrasound scan incidentally detected a large heterogeneous mass in the left upper quadrant...
  5. Pectasides D, Pectasides E, Papaxoinis G, Xiros N, Sykiotis C, Papachristodoulou A, et al. Combination chemotherapy with carboplatin, paclitaxel and pegylated liposomal doxorubicin for advanced or recurrent carcinosarcoma of the uterus: clinical experience of a single institution. Gynecol Oncol. 2008;110:299-303 pubmed publisher
    The purpose of this study was to evaluate the activity and toxicity of carboplatin, paclitaxel and pegylated liposomal doxorubicin combination in advanced or recurrent of the uterine carcinosarcoma.
  6. Powell M, Filiaci V, Rose P, Mannel R, Hanjani P, Degeest K, et al. Phase II evaluation of paclitaxel and carboplatin in the treatment of carcinosarcoma of the uterus: a Gynecologic Oncology Group study. J Clin Oncol. 2010;28:2727-31 pubmed publisher
    Platinum and taxane compounds have demonstrated activity in uterine carcinosarcoma (malignant mixed Mullerian tumor)...
  7. Tsao A, Wei W, Kuhn E, Spencer L, Solis L, Suraokar M, et al. Immunohistochemical overexpression of platelet-derived growth factor receptor-beta (PDGFR-?) is associated with PDGFRB gene copy number gain in sarcomatoid non-small-cell lung cancer. Clin Lung Cancer. 2011;12:369-74 pubmed publisher
    ..Further studies are warranted to determine whether PDGFR-b is a feasible therapeutic target in this population...
  8. Tanaka N, Hidaka S, Yamamura M, Ohyama H, Urade M. Metastatic cutaneous carcinosarcoma to the tongue. Int J Oral Maxillofac Surg. 2010;39:1033-6 pubmed publisher
    b>Carcinosarcoma is a rare malignant tumour composed of a mixture of carcinomatous and sarcomatous elements. Carcinosarcoma metastatic to the tongue is extremely rare. An 84-year-old woman presented with a rapidly growing mass on the tongue...
  9. Reed N. The management of uterine sarcomas. Clin Oncol (R Coll Radiol). 2008;20:470-8 pubmed publisher
    ..Given their relative uncommonness, centralisation of care and discussion at multi-disciplinary tumour boards is essential. International collaboration is essential...
  10. Tang P, Liu X, Zhang D, Fong W, Fung K. Pheophorbide a based photodynamic therapy induces apoptosis via mitochondrial-mediated pathway in human uterine carcinosarcoma. Cancer Biol Ther. 2009;8:533-9 pubmed publisher
    Uterine carcinosarcoma is an aggressive neoplasm with low survival rates because of the lack of very effective chemotherapy protocol. Photodynamic therapy (PDT) is recently suggested to be an efficient protocol for this cancer...
  11. Citil R, Ciralik H, Karsligıl A, Oltulu P, Yenıbertız D, Sayar H, et al. Carcinosarcoma of the lung associated with neurofibromatosis type 1: a case report. Turk Patoloji Derg. 2012;28:90-4 pubmed publisher
    ..b>Carcinosarcoma is a rare malignant mixed tumor of the lung...
  12. Koivisto Korander R, Butzow R, Koivisto A, Leminen A. Immunohistochemical studies on uterine carcinosarcoma, leiomyosarcoma, and endometrial stromal sarcoma: expression and prognostic importance of ten different markers. Tumour Biol. 2011;32:451-9 pubmed publisher
    ..receptor (AR), progesterone receptor A (PRA), and c-kit and their influence on survival in cases of uterine carcinosarcoma (CS), leiomyosarcoma (LMS), and endometrial stromal sarcoma (ESS) were evaluated...
  13. Sato S, Koike T, Yamato Y, Yoshiya K, Motono N, Takeshige M, et al. A case of rapidly growing pulmonary carcinosarcoma. Int J Clin Oncol. 2010;15:319-24 pubmed publisher
    We report herein a case of rapidly growing pulmonary carcinosarcoma, a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components, and we also ..
  14. Haj Salah M, Mekni A, Nouira Y, Haha Bellil S, Bellil K, Kchir N, et al. [Carcinosarcoma of the urinary bladder. Report of three cases]. Tunis Med. 2007;85:982-4 pubmed
    b>Carcinosarcoma of the urinary bladder is a very rare neoplasm accounting for less than 0,05% of urothelial tumours is a biphasic malignant neoplasm with only 79 cases reported in the English literature...
  15. Italiano A, Cortot A, Ilie M, Martel Planche G, Fabas T, Pop D, et al. EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: implications for anti-EGFR treatment of a rare lung malignancy. Int J Cancer. 2009;125:2479-82 pubmed publisher
    ..The rare incidence of increased EGFR gene copy number, the lack of EGFR mutation and the high rate of KRAS mutation observed in our series also suggest that most patients with lung SC are not likely to benefit from anti-EGFR therapies...
  16. Rauh Hain J, Growdon W, Rodriguez N, Goodman A, Boruta D, Schorge J, et al. Carcinosarcoma of the ovary: a case-control study. Gynecol Oncol. 2011;121:477-81 pubmed publisher
    b>Carcinosarcoma of the ovary is a rare tumor with a grim prognosis. Chemotherapy for these tumors is chosen according to guidelines established for epithelial ovarian cancer (EOC)...
  17. Almes K, Heaney A, Andrews G. Intracardiac ectopic thyroid carcinosarcoma in a dog. Vet Pathol. 2008;45:500-4 pubmed publisher
    ..Histopathologic diagnosis was an ectopic thyroid carcinosarcoma based on the presence of 3 distinct neoplastic tissue types...
  18. Choijamts B, Jimi S, Kondo T, Naganuma Y, Matsumoto T, Kuroki M, et al. CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Müllerian tumor). Stem Cells. 2011;29:1485-95 pubmed publisher
    ..We herein identify and characterize CSCs in human uterine carcinosarcoma (malignant mixed Müllerian tumor), which is one of the most aggressive and therapy-resistant gynecological ..
  19. Bertolini F, Rossi G, Fiocchi F, Giacometti M, Fontana A, Gibertini M, et al. Primary adrenal gland carcinosarcoma associated with metastatic rectal cancer: a hitherto unreported collision tumor. Tumori. 2011;97:27e-30e pubmed publisher
    ..specimen showed a collision tumor between an adrenal metastasis of a rectal tumor and a primary adrenal gland carcinosarcoma. The peculiarity of the case is due not only to its clinical presentation during pregnancy, but also to the ..
  20. Thway K, Olmos D, Shah C, Flora R, Shipley J, Fisher C. Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases. Am J Surg Pathol. 2012;36:470-7 pubmed publisher
    Adrenal cortical carcinosarcoma is a rare variant of adrenal cortical carcinoma. Sarcomatous change in adrenal cortical carcinomas is exceptionally rare, with only 9 cases previously described...
  21. Guntupalli S, Cao D, Shroff R, Gao F, Menias C, Stewart Massad L, et al. Wilms' tumor 1 protein and estrogen receptor beta expression are associated with poor outcomes in uterine carcinosarcoma. Ann Surg Oncol. 2013;20:2373-9 pubmed publisher
    Uterine carcinosarcoma (CS) is an aggressive malignancy...
  22. Rauh Hain J, Diver E, Clemmer J, Bradford L, Clark R, Growdon W, et al. Carcinosarcoma of the ovary compared to papillary serous ovarian carcinoma: a SEER analysis. Gynecol Oncol. 2013;131:46-51 pubmed publisher
    The aims of this study are to determine if outcomes of patients with ovarian carcinosarcoma (OCS) differ from women with high grade papillary serous ovarian carcinoma when compared by stage as well as to identify any associated clinico-..
  23. El Nashar S, Mariani A. Uterine carcinosarcoma. Clin Obstet Gynecol. 2011;54:292-304 pubmed publisher
    b>Carcinosarcoma is a rare but highly aggressive uterine malignancy. Pathologically, carcinosarcoma is a biphasic neoplasm composed of a mixture of malignant epithelial and mesenchymal components...
  24. Loizzi V, Cormio G, Leone L, Scardigno D, Carriero C, Resta L, et al. Carcinosarcoma of the vulva: a case report. J Obstet Gynaecol Res. 2010;36:705-8 pubmed publisher
    b>Carcinosarcoma is a well-recognized tumor even if it is an uncommon entity. Neoplasms usually occur in the oral cavity, pharynx, esophagus, larynx and skin, and have been rarely documented in the female genital tract...
  25. Miller B, Blessing J, Stehman F, Shahin M, Yamada S, Secord A, et al. A phase II evaluation of weekly gemcitabine and docetaxel for second-line treatment of recurrent carcinosarcoma of the uterus: a gynecologic oncology group study. Gynecol Oncol. 2010;118:139-44 pubmed publisher
    The objective of this study was to estimate antitumor activity and toxicity of weekly docetaxel and gemcitabine as second-line chemotherapy for patients with recurrent uterine carcinosarcoma.
  26. Olobatoke A, David D, Hafeez W, Van T, Saleh H. Pulmonary carcinosarcoma initially presenting as invasive aspergillosis: a case report of previously unreported combination. Diagn Pathol. 2010;5:11 pubmed publisher
    b>Carcinosarcoma of the lung is a malignant tumor composed of a mixture of carcinoma and sarcoma elements. The carcinomatous component is most commonly squamous followed by adenocarcinoma...
  27. Makker V, Abu Rustum N, Alektiar K, Aghajanian C, Zhou Q, Iasonos A, et al. A retrospective assessment of outcomes of chemotherapy-based versus radiation-only adjuvant treatment for completely resected stage I-IV uterine carcinosarcoma. Gynecol Oncol. 2008;111:249-54 pubmed publisher
    ..To determine the progression-free survival (PFS) and overall survival (OS) in a cohort of patients who received either platinum-based chemotherapy with or without radiation therapy (pelvic or WAI), or RT alone...
  28. Kourea H, Adonakis G, Androutsopoulos G, Zyli P, Kourounis G, Decavalas G. Fallopian tube malignant mixed müllerian tumor (carcinosarcoma): a case report with immunohistochemical profiling. Eur J Gynaecol Oncol. 2008;29:538-42 pubmed
    We report a case of malignant mixed müllerian tumor (MMMT) (carcinosarcoma) of the right fallopian tube in a 69-year-old woman presenting with abdominal pain and an adnexal mass...
  29. Spaziani E, Picchio M, Petrozza V, Briganti M, Ceci F, Di Filippo A, et al. Carcinosarcoma of the uterus: a case report and review of the literature. Eur J Gynaecol Oncol. 2008;29:531-4 pubmed
    b>Carcinosarcoma is a rare tumor of the uterus with a poor prognosis. We present a case of uterine carcinosarcoma in an 82-year-old woman who suffered from pervaginal bleeding for ten months duration with progressive anemia...
  30. Signorelli M, Chiappa V, Minig L, Fruscio R, Perego P, Caspani G, et al. Platinum, anthracycline, and alkylating agent-based chemotherapy for ovarian carcinosarcoma. Int J Gynecol Cancer. 2009;19:1142-6 pubmed publisher
    Ovarian carcinosarcoma (OCS) is a rare malignancy associated with a poor prognosis. Platinum, anthracyclines, and alkylating agents are the most effective antiblastic drugs for treatment of gynecologic epithelial and stromal tumors...
  31. Cantrell L, Van Le L. Carcinosarcoma of the ovary a review. Obstet Gynecol Surv. 2009;64:673-80; quiz 697 pubmed publisher
    b>Carcinosarcoma of the ovary, also referred to as mixed mullerian tumor of the ovary, is a rare and aggressive tumor. This tumor type is unique in that it contains malignant epithelial and stromal elements...
  32. Ang J, Shah R, Everard M, Keyzor C, Coombes I, Jenkins A, et al. A feasibility study of sequential doublet chemotherapy comprising carboplatin-doxorubicin and carboplatin-paclitaxel for advanced endometrial adenocarcinoma and carcinosarcoma. Ann Oncol. 2009;20:1787-93 pubmed publisher
    Platinum compounds, taxanes and anthracyclines provide the major effective drug classes in the treatment of advanced and recurrent endometrial cancer and carcinosarcoma.
  33. Coli A, Di Giorgio A, Castri F, Destito C, Marin A, Bigotti G. Sarcomatoid carcinoma of the adrenal gland: A case report and review of literature. Pathol Res Pract. 2010;206:59-65 pubmed publisher
    ..We review the reported cases according to the 2004 classification of the World Health Organization (WHO) of lung tumors, and highlight the histogenesis, diagnosis, and clinical course of this very aggressive tumor...
  34. Armstrong A, Wang M, Eble J, MacLennan G, Montironi R, Tan P, et al. TP53 mutational analysis supports monoclonal origin of biphasic sarcomatoid urothelial carcinoma (carcinosarcoma) of the urinary bladder. Mod Pathol. 2009;22:113-8 pubmed publisher
    ..Our results suggest that despite their conspicuous divergence at the phenotypic level, the sarcomatoid and carcinomatoid elements of this uncommon tumor share a common clonal origin...
  35. Nimeiri H, Oza A, Morgan R, Huo D, Elit L, Knost J, et al. A phase II study of sorafenib in advanced uterine carcinoma/carcinosarcoma: a trial of the Chicago, PMH, and California Phase II Consortia. Gynecol Oncol. 2010;117:37-40 pubmed publisher
    To determine the efficacy and safety of single agent sorafenib, an oral multi-targeted tyrosine kinase inhibitor, in patients with advanced uterine carcinoma and carcinosarcoma.
  36. Patel D, Dang S, Bentley F, Julka R, Olden K, Aduli F. Carcinosarcoma of the colon: a rare cause of colovesical fistula. Am Surg. 2009;75:335-7 pubmed
    ..Carcinosarcomas are very aggressive tumors associated with a poor prognosis. The first case of carcinosarcoma of the colon was reported in 1986...
  37. Lacour R, Euscher E, Atkinson E, Sun C, Ramirez P, Coleman R, et al. A phase II trial of paclitaxel and carboplatin in women with advanced or recurrent uterine carcinosarcoma. Int J Gynecol Cancer. 2011;21:517-22 pubmed publisher
    Systemic therapy for advanced uterine carcinosarcoma (CS) has been disappointing. The most widely studied regimen is ifosfamide and cisplatinum. Moderate success has been documented using paclitaxel in ovarian CS...
  38. Roma A, Malpica A, Deavers M. Malignant melanoma arising in an ovarian carcinosarcoma: case report and review of the literature. Int J Gynecol Pathol. 2011;30:158-62 pubmed publisher
    ..To the best of our knowledge, this is the first case of MMMT with melanocytic differentiation described in the ovary...
  39. Schaefer I, Enders C, Polten A, Haller F, Frölich A, Cameron S, et al. Common genomic aberrations in basaloid squamous cell carcinoma and carcinosarcoma of the esophagus detected by CGH and array CGH. Am J Clin Pathol. 2011;135:579-86 pubmed publisher
    Basaloid squamous cell carcinoma (BSCC) and carcinosarcoma of the esophagus are rare entities, making up fewer than 2% of esophageal malignancies...
  40. Jeong Y, Lee M, Kim J, Hwang P, Moon W, Chung M. Carcinosarcoma of the rectosigmoid colon in a 13-year-old girl. Pathol Int. 2008;58:445-50 pubmed publisher
    Reported herein is an unusual case of carcinosarcoma of the colon. A 13-year-old girl was transferred to Chonbuk National University Hospital, Korea with a known pelvic mass. CT and magnetic resonance imaging confirmed a large pelvic mass...
  41. Genever A, Abdi S. Can MRI predict the diagnosis of endometrial carcinosarcoma?. Clin Radiol. 2011;66:621-4 pubmed publisher
    To ascertain whether magnetic resonance imaging (MRI) can be used to suggest a diagnosis of endometrial carcinosarcoma.
  42. Filip A, Clichici S, Muresan A, Daicoviciu D, Tatomir C, Login C, et al. Effects of PDT with 5-aminolevulinic acid and chitosan on Walker carcinosarcoma. Exp Oncol. 2008;30:212-9 pubmed
    ..Porphyrins and new chitosan hydrogels based composites with porphyrins are used as active cytotoxic antitumor agents in photodynamic therapy (PDT)...
  43. Carrara L, Guzzo F, Roque D, Bellone S, Emiliano C, Sartori E, et al. Differential in vitro sensitivity to patupilone versus paclitaxel in uterine and ovarian carcinosarcoma cell lines is linked to tubulin-beta-III expression. Gynecol Oncol. 2012;125:231-6 pubmed publisher
    ..To compare the in vitro sensitivity/resistance to patupilone versus paclitaxel in uterine and ovarian carcinosarcomas (CS)...
  44. Reed N, Mangioni C, Malmstrom H, Scarfone G, Poveda A, Pecorelli S, et al. Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874). Eur J Cancer. 2008;44:808-18 pubmed publisher
    ..CS appears to show more kinship to poorly differentiated endometrial carcinomas in behaviour. LMS did not show the same benefit from radiation. These results will help shape future management and clinical trials in uterine sarcomas...
  45. Huang G, Gunter M, Arend R, Li M, Arias Pulido H, Prossnitz E, et al. Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol. 2010;203:242.e1-5 pubmed publisher
    We sought to evaluate the expression of G protein-coupled receptor 30 (GPR30) and estrogen receptor (ER)beta in uterine carcinosarcoma (CS).
  46. Galaal K, van der Heijden E, Godfrey K, Naik R, Kucukmetin A, Bryant A, et al. Adjuvant radiotherapy and/or chemotherapy after surgery for uterine carcinosarcoma. Cochrane Database Syst Rev. 2013;:CD006812 pubmed publisher
    ..The survival of women with advanced uterine carcinosarcoma is poor with a pattern of failure indicating greater likelihood of upper abdominal and distant metastatic ..
  47. Schipf A, Mayr D, Kirchner T, Diebold J. Molecular genetic aberrations of ovarian and uterine carcinosarcomas--a CGH and FISH study. Virchows Arch. 2008;452:259-68 pubmed publisher
    ..Furthermore, the observed patterns of genetic aberrations are highly similar to those of serous carcinomas. This is compatible with the current opinion that these neoplasms should be considered as metaplastic carcinomas...
  48. Clayton Smith D, Kenneth Macdonald O, Gaffney D. The impact of adjuvant radiation therapy on survival in women with uterine carcinosarcoma. Radiother Oncol. 2008;88:227-32 pubmed
    Uterine carcinosarcoma is an aggressive neoplasm and the benefit of adjuvant radiation therapy (RT) is unclear. This retrospective study analyzes the influence of RT on survival using a large population database.
  49. Castilla M, Moreno Bueno G, Romero Pérez L, Van De Vijver K, Biscuola M, Lopez Garcia M, et al. Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma. J Pathol. 2011;223:72-80 pubmed publisher
    ..These data suggest that in human ECS, the interplay between transcriptional repressors of E-cadherin and miRNAs provides a link between EMT-activation and the maintenance of stemness...
  50. Sasaki K, Desimone M, Rao H, Huang G, Seethala R. Adrenocortical carcinosarcoma: a case report and review of the literature. Diagn Pathol. 2010;5:51 pubmed publisher
    Adrenocortical carcinosarcoma is an extremely rare and aggressive variant of adrenocortical carcinoma characterized by the presence of both carcinomatous and sarcomatous components, with the latter often showing heterologous ..
  51. Vékony H, Leemans C, Ylstra B, Meijer G, van der Waal I, Bloemena E. Salivary gland carcinosarcoma: oligonucleotide array CGH reveals similar genomic profiles in epithelial and mesenchymal components. Oral Oncol. 2009;45:259-65 pubmed publisher
    In this study, we present a case of parotid gland de novo carcinosarcoma. Salivary gland carcinosarcoma (or true malignant mixed tumor) is a rare biphasic neoplasm, composed of both malignant epithelial and malignant mesenchymal ..
  52. Shimizu S, Yajima M, Yoshii A, Nishikawa T, Ohta H. Malignant pericardial effusion and cardiac tamponade originating from uterine carcinosarcoma. Arch Gynecol Obstet. 2009;279:373-5 pubmed publisher
    ..Cardiac tamponade caused by gynecologic malignancies are extremely rare...
  53. Wright J, Seshan V, Shah M, Schiff P, Burke W, Cohen C, et al. The role of radiation in improving survival for early-stage carcinosarcoma and leiomyosarcoma. Am J Obstet Gynecol. 2008;199:536.e1-8 pubmed publisher
    ..We examined the effect of radiation on survival for early-stage uterine carcinosarcomas and leiomyosarcomas...
  54. Kowalewska M, Danska Bidzinska A, Bakula Zalewska E, Bidzinski M. Identification of suitable reference genes for gene expression measurement in uterine sarcoma and carcinosarcoma tumors. Clin Biochem. 2012;45:368-71 pubmed publisher
    ..The purpose of this study was to select appropriate references for gene expression studies in these tumors...
  55. Cantrell L, Havrilesky L, Moore D, O Malley D, Liotta M, Secord A, et al. A multi-institutional cohort study of adjuvant therapy in stage I-II uterine carcinosarcoma. Gynecol Oncol. 2012;127:22-6 pubmed publisher
    To evaluate the impact of adjuvant post-operative therapy in women with early stage uterine carcinosarcoma.
  56. Matsuo K, Bond V, Im D, Rosenshein N. Prediction of Chemotherapy Response With Platinum and Taxane in the Advanced Stage of Ovarian and Uterine Carcinosarcoma: A Clinical Implication of In vitro Drug Resistance Assay. Am J Clin Oncol. 2010;33:358-63 pubmed publisher
    To evaluate the role of an in vitro drug resistance assay to predict the response to platinum and taxane combination chemotherapy in advanced ovarian and uterine carcinosarcoma.
  57. Liu J, Wu H. Carcinosarcoma of female urethra with melanocytic differentiation. Int J Clin Exp Pathol. 2011;4:206-9 pubmed
    b>Carcinosarcoma arising from the female urethra is rare. We report an unusual case of urethral carcinosarcoma from a female patient with melanocytic differentiation...
  58. Lee Y, Park N, Lee H. Prognostic value of alternative lengthening of telomeres-associated biomarkers in uterine sarcoma and uterine carcinosarcoma. Int J Gynecol Cancer. 2012;22:434-41 pubmed publisher
    ..The goal of this study was to evaluate the frequency of ALT in uterine sarcoma and carcinosarcoma and to assess its association with clinical parameters.
  59. Kochar K, Vijayasekar C, Pandey U, Bhogal R, Brown L, Mathew G. Primary carcinosarcoma of the spleen: case report of a rare tumor and review of the literature. Int J Surg Pathol. 2009;17:72-7 pubmed publisher
    b>Carcinosarcoma of extragenital organs is rare. In this article, a case of primary carcinosarcoma of the spleen, which presented as painful splenomegaly is reported...
  60. Suprasert P, Khunamornpong S. Carcinosarcoma arising in uterine didelphys after tamoxifen therapy for breast cancer: a case report. J Med Assoc Thai. 2010;93:608-12 pubmed
    ..72 our knowledge, an association between uterine anomaly and uterine carcinosarcoma in these patients had not been reported...