spinal neoplasms

Summary

Summary: New abnormal growth of tissue in the SPINE.

Top Publications

  1. Chiang A, Zeng L, Zhang L, Lochray F, Korol R, Loblaw A, et al. Pain flare is a common adverse event in steroid-naïve patients after spine stereotactic body radiation therapy: a prospective clinical trial. Int J Radiat Oncol Biol Phys. 2013;86:638-42 pubmed publisher
    ..To determine the incidence of pain flare after spine stereotactic body radiation therapy (SBRT) in steroid-naïve patients and identify predictive factors...
  2. Pilge H, Holzapfel B, Prodinger P, Hadjamu M, Gollwitzer H, Rechl H. [Diagnostics and therapy of spinal metastases]. Orthopade. 2011;40:185-93; quiz 194-5 pubmed publisher
    ..Therapy is palliative with the aim of pain relief and preservation of mobility. In cases of solitary metastasis a curative operative treatment should be performed...
  3. Nelson J, Yoo D, Sampson J, Isaacs R, Larrier N, Marks L, et al. Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. Int J Radiat Oncol Biol Phys. 2009;73:1369-75 pubmed publisher
    ..To describe our experience and clinical strategy for stereotactic body radiotherapy (SBRT) of spinal lesions...
  4. Sheehan J, Jagannathan J. Review of spinal radiosurgery: a minimally invasive approach for the treatment of spinal and paraspinal metastases. Neurosurg Focus. 2008;25:E18 pubmed publisher
    ..Spinal radiosurgery has expanded the neurosurgical treatment armamentarium for patients with spinal and paraspinal metastasis...
  5. Clarke M, Dasenbrock H, Bydon A, Sciubba D, McGirt M, Hsieh P, et al. Posterior-only approach for en bloc sacrectomy: clinical outcomes in 36 consecutive patients. Neurosurgery. 2012;71:357-64; discussion 364 pubmed publisher
    ..However, we have found that en bloc resection and biomechanical reconstruction of the spinal column is possible from a posterior-only approach in many cases...
  6. Damast S, Wright J, Bilsky M, Hsu M, Zhang Z, Lovelock M, et al. Impact of dose on local failure rates after image-guided reirradiation of recurrent paraspinal metastases. Int J Radiat Oncol Biol Phys. 2011;81:819-26 pubmed publisher
    ..To examine the impact of dose on local failure (LF) rates in the re-treatment of recurrent paraspinal metastases with image-guided intensity-modulated radiotherapy (IG-IMRT)...
  7. Bilsky M, Laufer I, Fourney D, Groff M, Schmidt M, Varga P, et al. Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine. 2010;13:324-8 pubmed publisher
    ..The degree of ESCC often serves as a major determinant in the decision to operate or irradiate. The purpose of this study was to determine the reliability and validity of a 6-point, MR imaging-based grading system for ESCC...
  8. Poleksić Z, Lalosević V, Milinković Z. Osteoblastoma of the spine. Acta Chir Iugosl. 2010;57:63-8 pubmed
    ..5%) pati-ents. Clearly delineated lesions were treated by an intralesional procedure, but aggressive ones were treated by a marginal surgery followed by additional radiotherapy (6 patients). The average follow-up period was 13 years...
  9. Karchevsky M, Babb J, Schweitzer M. Can diffusion-weighted imaging be used to differentiate benign from pathologic fractures? A meta-analysis. Skeletal Radiol. 2008;37:791-5 pubmed publisher
    ..As each of these studies contained somewhat small numbers of patients, we performed a meta-analysis to determine if this sequence may be used for this important diagnostic problem...

More Information

Publications62

  1. Samdani A, Torre Healy A, Chou D, Cahill A, Storm P. Treatment of osteoblastoma at C7: a multidisciplinary approach. A case report and review of the literature. Eur Spine J. 2009;18 Suppl 2:196-200 pubmed publisher
    ..This multidisciplinary approach markedly decreased blood loss and improved visualization to help achieve complete surgical resection and resolution of clinical symptoms...
  2. Kawahara N, Tomita K, Murakami H, Demura S. Total en bloc spondylectomy for spinal tumors: surgical techniques and related basic background. Orthop Clin North Am. 2009;40:47-63, vi pubmed publisher
    ..Review of the developmental process of this operation leads to recognition of the tips, pitfalls, and solutions...
  3. Ofluoglu O. Minimally invasive management of spinal metastases. Orthop Clin North Am. 2009;40:155-68, viii pubmed publisher
  4. Kurup A, Woodrum D, Morris J, Atwell T, Schmit G, Welch T, et al. Cryoablation of recurrent sacrococcygeal tumors. J Vasc Interv Radiol. 2012;23:1070-5 pubmed publisher
    ..To review the safety and efficacy of cryoablation of recurrent sacrococcygeal tumors...
  5. Garg A, Shiu A, Yang J, Wang X, Allen P, Brown B, et al. Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases. Cancer. 2012;118:5069-77 pubmed publisher
    ..In this phase 1/2 study, the authors tested the hypothesis that single-fraction stereotactic body radiotherapy (SBRT) for previously unirradiated spinal metastases is a safe, feasible, and efficacious treatment approach...
  6. Santillan A, Zink W, Lavi E, Boockvar J, Gobin Y, Patsalides A. Endovascular embolization of cervical hemangiopericytoma with Onyx-18: case report and review of the literature. J Neurointerv Surg. 2011;3:304-7 pubmed publisher
    ..Preoperative embolization with Onyx-18 should be considered for large HPC as it may decrease the risk of intraoperative hemorrhage. In this case, embolization with Onyx-18 did not preclude histopathologic diagnosis of HPC...
  7. Ramme A, Smucker J. Balancing spinal stability and future mobility in the cervical spine: surgical treatment of a case of osteoblastoma with secondary aneurysmal bone cyst. Spine J. 2011;11:e5-12 pubmed publisher
    ..Complete resection has been shown to be the most effective method for preventing recurrence; however, balancing spinal stability, future mobility, and complete resection is especially important in active young patients...
  8. McGirt M, Gokaslan Z, Chaichana K. Preoperative grading scale to predict survival in patients undergoing resection of malignant primary osseous spinal neoplasms. Spine J. 2011;11:190-6 pubmed publisher
    Large population-based studies of malignant primary osseous spinal neoplasms are lacking and are necessary to have sufficient statistical power to determine if various patient-related factors are in fact significant indicators of prognosis...
  9. Mukherjee D, Chaichana K, Gokaslan Z, Aaronson O, Cheng J, McGirt M. Survival of patients with malignant primary osseous spinal neoplasms: results from the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2003. J Neurosurg Spine. 2011;14:143-50 pubmed publisher
    Malignant primary osseous spinal neoplasms are aggressive tumors that remain associated with poor outcomes despite aggressive multidisciplinary treatment measures...
  10. Lucas D. Osteoblastoma. Arch Pathol Lab Med. 2010;134:1460-6 pubmed publisher
  11. Bilginer B, Soylemezoglu F, Cila A, Akalan N. Intraventricular dysembryoplastic neuroepithelial tumor-like neoplasm with disseminated spinal tumor. Turk Neurosurg. 2009;19:69-72 pubmed
  12. Gibbs I, Patil C, Gerszten P, Adler J, Burton S. Delayed radiation-induced myelopathy after spinal radiosurgery. Neurosurgery. 2009;64:A67-72 pubmed publisher
    ..We report a case series of 6 patients treated with radiosurgery who developed delayed myelopathy...
  13. Haley M, Gerszten P, Heron D, Chang Y, Atteberry D, Burton S. Efficacy and cost-effectiveness analysis of external beam and stereotactic body radiation therapy in the treatment of spine metastases: a matched-pair analysis. J Neurosurg Spine. 2011;14:537-42 pubmed publisher
  14. Fourney D, Frangou E, Ryken T, DiPaola C, Shaffrey C, Berven S, et al. Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group. J Clin Oncol. 2011;29:3072-7 pubmed publisher
    ..The objective of this study was to determine the interobserver reliability, intraobserver reliability, and predictive validity of the Spinal Instability Neoplastic Score (SINS)...
  15. Weber M, Burch S, Buckley J, Schmidt M, Fehlings M, Vrionis F, et al. Instability and impending instability of the thoracolumbar spine in patients with spinal metastases: a systematic review. Int J Oncol. 2011;38:5-12 pubmed
    ..Improved clinical research methodology for this patient population is required...
  16. Rief H, Jensen A, Bruckner T, Herfarth K, Debus J. Isometric muscle training of the spine musculature in patients with spinal bony metastases under radiation therapy. BMC Cancer. 2011;11:482 pubmed publisher
  17. Molina C, Gokaslan Z, Sciubba D. Diagnosis and management of metastatic cervical spine tumors. Orthop Clin North Am. 2012;43:75-87, viii-ix pubmed publisher
    ..Management ranges from palliative nonoperative to aggressive surgical treatment. Optimal management requires proper patient selection to individualize the most appropriate treatment modality...
  18. Nakamura N, Shikama N, Wada H, Harada H, Nozaki M, Nagakura H, et al. Patterns of practice in palliative radiotherapy for painful bone metastases: a survey in Japan. Int J Radiat Oncol Biol Phys. 2012;83:e117-20 pubmed publisher
    ..To determine the current patterns of practice in Japan and to investigate factors that may make clinicians reluctant to use single-fraction radiotherapy (SF-RT)...
  19. Choi C, Adler J, Gibbs I, Chang S, Jackson P, Minn A, et al. Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord. Int J Radiat Oncol Biol Phys. 2010;78:499-506 pubmed publisher
    ..As the spinal cord tolerance often precludes reirradiation with conventional techniques, local recurrence within a previously irradiated field presents a treatment challenge...
  20. Chi J, Gokaslan Z. Vertebroplasty and kyphoplasty for spinal metastases. Curr Opin Support Palliat Care. 2008;2:9-13 pubmed publisher
    ..Minimally invasive surgical techniques have been developed over the past several years, offering a simple and effective way of managing painful pathologic fractures...
  21. Ahmed K, Stauder M, Miller R, Bauer H, Rose P, Olivier K, et al. Stereotactic body radiation therapy in spinal metastases. Int J Radiat Oncol Biol Phys. 2012;82:e803-9 pubmed publisher
    ..Based on reports of safety and efficacy, stereotactic body radiotherapy (SBRT) for treatment of malignant spinal tumors was initiated at our institution. We report prospective results of this population at Mayo Clinic...
  22. Guckenberger M, Goebel J, Wilbert J, Baier K, Richter A, Sweeney R, et al. Clinical outcome of dose-escalated image-guided radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2009;75:828-35 pubmed publisher
    ..To evaluate the outcomes after dose-escalated radiotherapy (RT) for spinal metastases and paraspinal tumors...
  23. Sciubba D, Petteys R, Dekutoski M, Fisher C, Fehlings M, Ondra S, et al. Diagnosis and management of metastatic spine disease. A review. J Neurosurg Spine. 2010;13:94-108 pubmed publisher
    ..Ultimately, the goal of treatment in patients with spinal metastases remains palliative, and clinical judgment is required to select the appropriate patients for surgical intervention...
  24. Asavamongkolkul A, Waikakul S. Wide resection of sacral chordoma via a posterior approach. Int Orthop. 2012;36:607-12 pubmed publisher
    ..The study was carried out to report the results of wide resection in sacral chordoma using a posterior approach and gauze packing technique...
  25. Demura S, Kawahara N, Murakami H, Abdel Wanis M, Kato S, Yoshioka K, et al. Total en bloc spondylectomy for spinal metastases in thyroid carcinoma. J Neurosurg Spine. 2011;14:172-6 pubmed publisher
    ..The purposes of the present study are to determine the strategy of surgical treatment for spinal metastases of thyroid carcinoma and to evaluate the surgical results of and the prognosis associated with TES...
  26. Chao S, Koyfman S, Woody N, Angelov L, Soeder S, Reddy C, et al. Recursive partitioning analysis index is predictive for overall survival in patients undergoing spine stereotactic body radiation therapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2012;82:1738-43 pubmed publisher
    ..To generate a prognostic index using recursive partitioning analysis (RPA) for patients undergoing spine stereotactic body radiation therapy (sSBRT) for spinal metastases (sMet)...
  27. Imai R, Kamada T, Sugahara S, Tsuji H, Tsujii H. Carbon ion radiotherapy for sacral chordoma. Br J Radiol. 2011;84 Spec No 1:S48-54 pubmed publisher
    ..15 patients experienced severe sciatic nerve complications requiring continuing medication. CIRT appears effective and safe in the management of patients with sacral chordoma and offers a promising alternative to surgery...
  28. Lee J, Bhatia N, Hoang B, Ziogas A, Zell J. Analysis of prognostic factors for patients with chordoma with use of the California Cancer Registry. J Bone Joint Surg Am. 2012;94:356-63 pubmed publisher
    ..Using data from a large, population-based cancer registry, we designed the present study to examine the outcome for patients with chordoma and to determine relevant prognostic factors...
  29. Boriani S, Amendola L, Bandiera S, Simoes C, Alberghini M, Di Fiore M, et al. Staging and treatment of osteoblastoma in the mobile spine: a review of 51 cases. Eur Spine J. 2012;21:2003-10 pubmed publisher
    ..To define the role of Enneking staging system and of the consequent different treatment options on the outcome of osteoblastoma (OBL) of the spine...
  30. Moskowitz R, Young J, Box G, Paré L, Clayman R. Retroperitoneal transdiaphragmatic robotic-assisted laparoscopic resection of a left thoracolumbar neurofibroma. JSLS. 2009;13:64-8 pubmed
    ..This report describes the first use of robotic technology to resect a left thoracolumbar neurofibroma...
  31. Sciubba D, Petteys R, Kang S, Than K, Gokaslan Z, Gallia G, et al. Solitary spinal metastasis of Hürthle cell thyroid carcinoma. J Clin Neurosci. 2010;17:797-801 pubmed publisher
    ..We discuss aspects of the diagnosis, management, patient selection, and surgical treatment of metastatic Hürthle cell carcinoma in reference to the literature...
  32. Yang H, Zhu L, Ebraheim N, Liu J, Shapiro A, Castillo S, et al. Surgical treatment of sacral chordomas combined with transcatheter arterial embolization. J Spinal Disord Tech. 2010;23:47-52 pubmed publisher
    ..A retrospective study, analyzing midterm results of transcatheter arterial embolization (TAE) for removal of a sacral chordoma...
  33. Yang Z, Yang D, Xie L, Sun Y, Huang Y, Sun H, et al. Treatment of metastatic spinal tumors by percutaneous vertebroplasty versus percutaneous vertebroplasty combined with interstitial implantation of 125I seeds. Acta Radiol. 2009;50:1142-8 pubmed publisher
    ..To avoid the trauma and complications of open surgery, a minimally invasive procedure, percutaneous vertebroplasty (PVP), has recently been developed to treat metastatic spinal tumors...
  34. Gerszten P, Mendel E, Yamada Y. Radiotherapy and radiosurgery for metastatic spine disease: what are the options, indications, and outcomes?. Spine (Phila Pa 1976). 2009;34:S78-92 pubmed publisher
    ..Systematic literature review...
  35. Sciubba D, Nguyen T, Gokaslan Z. Solitary vertebral metastasis. Orthop Clin North Am. 2009;40:145-54, viii pubmed publisher
  36. Moulding H, Elder J, Lis E, Lovelock D, Zhang Z, Yamada Y, et al. Local disease control after decompressive surgery and adjuvant high-dose single-fraction radiosurgery for spine metastases. J Neurosurg Spine. 2010;13:87-93 pubmed publisher
    ..In this series, those patients who received a higher radiosurgical dose had a significantly better local control rate...
  37. Chang U, Cho W, Kim M, Cho C, Lee D, Rhee C. Local tumor control after retreatment of spinal metastasis using stereotactic body radiotherapy; comparison with initial treatment group. Acta Oncol. 2012;51:589-95 pubmed publisher
    ..The aim of this study is to evaluate local control rates after stereotactic body radiotherapy (SBRT) in recurrent spinal metastasis after external beam radiotherapy (EBRT) and new spinal metastatic lesions...
  38. Rades D, Abrahm J. The role of radiotherapy for metastatic epidural spinal cord compression. Nat Rev Clin Oncol. 2010;7:590-8 pubmed publisher
    ..Larger prospective trials are required to better define the appropriate treatment for the individual patient...
  39. Sahgal A, Ma L, Weinberg V, Gibbs I, Chao S, Chang U, et al. Reirradiation human spinal cord tolerance for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2012;82:107-16 pubmed publisher
  40. Aizenberg M, Fox B, Suki D, McCutcheon I, Rao G, Rhines L. Surgical management of unknown primary tumors metastatic to the spine. J Neurosurg Spine. 2012;16:86-92 pubmed publisher
    ..Patients presenting with spinal metastases from unknown primary tumors (UPTs) are rare. The authors reviewed their surgical experience to evaluate outcomes and identify predictors of survival in these patients...
  41. Souchon R, Wenz F, Sedlmayer F, Budach W, Dunst J, Feyer P, et al. DEGRO practice guidelines for palliative radiotherapy of metastatic breast cancer: bone metastases and metastatic spinal cord compression (MSCC). Strahlenther Onkol. 2009;185:417-24 pubmed publisher
    ..To provide practice guidelines and clinical recommendations on preferred standard palliative radiation therapy of bone metastases as well as metastatic spinal cord compression (MSCC) for metastatic breast cancer patients...
  42. Tancioni F, Lorenzetti M, Navarria P, Pessina F, Draghi R, Pedrazzoli P, et al. Percutaneous vertebral augmentation in metastatic disease: state of the art. J Support Oncol. 2011;9:4-10 pubmed
  43. Sahgal A, Bilsky M, Chang E, Ma L, Yamada Y, Rhines L, et al. Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient. J Neurosurg Spine. 2011;14:151-66 pubmed publisher
    ..The focus of this review was to examine the evidence pertaining to spine SBRT in the treatment of spinal metastases and to provide a comprehensive analysis of published patterns of failure, with emphasis on the postoperative patient...
  44. Ropper A, Cahill K, Hanna J, McCarthy E, Gokaslan Z, Chi J. Primary vertebral tumors: a review of epidemiologic, histological, and imaging findings, Part I: benign tumors. Neurosurgery. 2011;69:1171-80 pubmed publisher
    ..In combination with part II of the review, which focuses on locally aggressive and malignant tumors, this article provides a comprehensive review of primary vertebral tumors...
  45. Arrigo R, Kalanithi P, Cheng I, Alamin T, Carragee E, Mindea S, et al. Predictors of survival after surgical treatment of spinal metastasis. Neurosurgery. 2011;68:674-81; discussion 681 pubmed publisher
  46. Ruggieri P, Angelini A, Ussia G, Montalti M, Mercuri M. Surgical margins and local control in resection of sacral chordomas. Clin Orthop Relat Res. 2010;468:2939-47 pubmed publisher
    ..The quality of surgical margins obtained at initial surgery is the primary factor to improve survival reducing the risk of local recurrence, but proximal sacral resections are associated with substantial perioperative morbidity...
  47. Kushchayev S, Kushchayeva Y, Theodore N, Preul M, Clark O. Percutaneous vertebroplasty for thyroid cancer metastases to the spine. Thyroid. 2010;20:555-60 pubmed publisher
    ..Such treatment may also relieve pain and improve survival and quality of life...
  48. Garvey P, Rhines L, Dong W, Chang D. Immediate soft-tissue reconstruction for complex defects of the spine following surgery for spinal neoplasms. Plast Reconstr Surg. 2010;125:1460-6 pubmed publisher
    ..surgical approaches and instrumentation for spinal stabilization have allowed radical resections of advanced spinal neoplasms. Wounds that expose instrumentation and vital neural structures can have devastating consequences...
  49. Guckenberger M, Hawkins M, Flentje M, Sweeney R. Fractionated radiosurgery for painful spinal metastases: DOSIS - a phase II trial. BMC Cancer. 2012;12:530 pubmed publisher
    ..3) Dose intensification will be performed in the involved parts of the vertebrae only, while uninvolved parts are treated with conventional doses using the simultaneous integrated boost concept...
  50. Garg A, Wang X, Shiu A, Allen P, Yang J, McAleer M, et al. Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: The University of Texas MD Anderson Cancer Center experience. Cancer. 2011;117:3509-16 pubmed publisher
    ..The authors review a prospective series of spinal metastasis patients reirradiated with stereotactic body radiotherapy...
  51. Stieler F, Wolff D, BAUER L, Wertz H, Wenz F, Lohr F. Reirradiation of spinal column metastases: comparison of several treatment techniques and dosimetric validation for the use of VMAT. Strahlenther Onkol. 2011;187:406-15 pubmed publisher
    ..We analyzed the potential of volumetric modulated arc therapy (VMAT) to reduce treatment time and number of monitor units (MU)...
  52. Leithner A, Radl R, Gruber G, Hochegger M, Leithner K, Welkerling H, et al. Predictive value of seven preoperative prognostic scoring systems for spinal metastases. Eur Spine J. 2008;17:1488-95 pubmed publisher
    ..However, decision for or against surgery should never be based alone on a prognostic score but should take symptoms like pain or neurological compromise into account...
  53. Mizumoto M, Harada H, Asakura H, Hashimoto T, Furutani K, Hashii H, et al. Prognostic factors and a scoring system for survival after radiotherapy for metastases to the spinal column: a review of 544 patients at Shizuoka Cancer Center Hospital. Cancer. 2008;113:2816-22 pubmed publisher
    ..To optimize selection of a radiotherapy schedule for patients with spinal metastases, the authors analyzed prognostic factors and developed a scoring system to predict survival in such patients...