jaw neoplasms

Summary

Summary: Cancers or tumors of the MAXILLA or MANDIBLE unspecified. For neoplasms of the maxilla, MAXILLARY NEOPLASMS is available and of the mandible, MANDIBULAR NEOPLASMS is available.

Top Publications

  1. Madras J, Lapointe H. Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. J Can Dent Assoc. 2008;74:165-165h pubmed
    ..Future treatment may involve molecular-based modalities, which may reduce or eliminate the need for aggressive surgical management...
  2. Cascon A, Huarte Mendicoa C, Javier Leandro García L, Leton R, Suela J, Santana A, et al. Detection of the first gross CDC73 germline deletion in an HPT-JT syndrome family. Genes Chromosomes Cancer. 2011;50:922-9 pubmed publisher
    ..The finding of the first rearrangement affecting the CDC73 gene warrants screening for this tumor suppressor gene inactivation mechanism not only in high-risk CDC73 point mutation-negative HPT-JT families, but also in FIHP patients...
  3. Hande A, Gadbail A, Sonone A, Chaudhary M, Wadhwan V, Nikam A. Comparative analysis of tumour angiogenesis in solid multicystic and unicystic ameloblastoma by using CD 105 (endoglin). Arch Oral Biol. 2011;56:1635-40 pubmed publisher
    ..The aim of the present study was to evaluate and compare the expression of CD105 (endoglin) in solid multicystic ameloblastoma (SMA) and unicystic ameloblastoma (UA)...
  4. Butt F, Guthua S, Awange D, Dimba E, Macigo F. The pattern and occurrence of ameloblastoma in adolescents treated at a university teaching hospital, in Kenya: a 13-year study. J Craniomaxillofac Surg. 2012;40:e39-45 pubmed publisher
    ..Ameloblastoma presenting in the adolescent age group is rare with few studies documenting their occurrence...
  5. Mendes R, Carvalho J, van der Waal I. Biological pathways involved in the aggressive behavior of the keratocystic odontogenic tumor and possible implications for molecular oriented treatment - an overview. Oral Oncol. 2010;46:19-24 pubmed publisher
  6. Mendenhall W, Werning J, Fernandes R, Malyapa R, Mendenhall N. Ameloblastoma. Am J Clin Oncol. 2007;30:645-8 pubmed
    ..The optimal treatment for ameloblastoma is wide en bloc resection. Radiotherapy may improve the likelihood of local control in the occasional patient with incompletely resectable tumor...
  7. Jegoux F, Malard O, Goyenvalle E, Aguado E, Daculsi G. Radiation effects on bone healing and reconstruction: interpretation of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:173-84 pubmed publisher
    ..Reconstructing irradiated mandibles with biomaterials is still a challenge but little investigated. We collected data that could help us understand studies in the field of regeneration with biomaterials and irradiated bone...
  8. Mendes R, Carvalho J, van der Waal I. Characterization and management of the keratocystic odontogenic tumor in relation to its histopathological and biological features. Oral Oncol. 2010;46:219-25 pubmed publisher
    ..The key element for future management of KCOTs will probably be based on thorough knowledge of the biological basis of this tumor, thereby enabling a more tailored treatment approach...
  9. Wang A, Zhang B, Huang H, Zhang L, Zeng D, Tao Q, et al. Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro. BMC Cancer. 2008;8:182 pubmed publisher
    ..Ameloblastomas are odontogenic neoplasms characterized by local invasiveness. This study was conducted to address the role of matrix metalloproteinase-2 (MMP-2) in the invasiveness of ameloblastomas...

More Information

Publications62

  1. Kibe T, Fuchigami T, Kishida M, Iijima M, Ishihata K, Hijioka H, et al. A novel ameloblastoma cell line (AM-3) secretes MMP-9 in response to Wnt-3a and induces osteoclastogenesis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;115:780-8 pubmed publisher
    ..However, the mechanisms of bone invasion in ameloblastoma remain unclear. In this study, we established an experimental model for matrix metalloproteinase (MMP) induction and osteoclastogenesis using ameloblastoma-derived cells...
  2. Jiang L, Shao C, He D, Li W, Wu X, Cai D. [Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma]. Ai Zheng. 2008;27:1263-6 pubmed
    ..This study was to evaluate the role of matrix metalloproteinase inducer (EMMPRIN) in angiogenesis in ameloblastomas by analyzing EMMPRIN expression and microvessel density (MVD) in ameloblastomas and odontogenic cysts...
  3. Alaeddini M, Salah S, Dehghan F, Eshghyar N, Etemad Moghadam S. Comparison of angiogenesis in keratocystic odontogenic tumours, dentigerous cysts and ameloblastomas. Oral Dis. 2009;15:422-7 pubmed publisher
    ..The aim of the present study was to evaluate and compare angiogenesis in keratocystic odontogenic tumours, dentigerous cysts (DCs) and ameloblasomas using monoclonal antibody against CD34...
  4. Iezzi G, Piattelli A, Rubini C, Artese L, Goteri G, Fioroni M, et al. CD10 expression in stromal cells of ameloblastoma variants. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:206-9 pubmed
  5. Hertog D, Schulten E, Leemans C, Winters H, van der Waal I. Management of recurrent ameloblastoma of the jaws; a 40-year single institution experience. Oral Oncol. 2011;47:145-6 pubmed publisher
    ..5 years. The three patients who refused radical surgery all developed one or more new recurrences...
  6. Padilla R, Murrah V. The spectrum of gnathic osteosarcoma: caveats for the clinician and the pathologist. Head Neck Pathol. 2011;5:92-9 pubmed publisher
    ..Based on the positive outcomes of the patients in our series, the prognosis of GO appears to be relatively favorable when compared to other sarcomas and osteosarcomas of long bones...
  7. Alaeddini M, Etemad Moghadam S, Baghaii F. Comparative expression of calretinin in selected odontogenic tumours: a possible relationship to histogenesis. Histopathology. 2008;52:299-304 pubmed publisher
    ..It has also been reported to be present in mesotheliomas and other tumours. The aim was to determine the expression of calretinin in selected odontogenic neoplasms...
  8. Lee B, Lee W, Oh S, Min S, Kim E. A case report of Gardner syndrome with hereditary widespread osteomatous jaw lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:e68-72 pubmed publisher
    ..This case demonstrates the presence of unusual, widespread, hereditary, osteomatous jaw lesions that caused diagnostic confusion with familial gigantiform cementoma...
  9. Granowski LeCornu M, Chuang S, Kaban L, August M. Osteosarcoma of the jaws: factors influencing prognosis. J Oral Maxillofac Surg. 2011;69:2368-75 pubmed publisher
  10. Philipsen H, Reichart P, Siar C, Ng K, Lau S, Zhang X, et al. An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study. J Oral Pathol Med. 2007;36:383-93 pubmed
    ..Adenomatoid odontogenic tumour (AOT) is a benign odontogenic jaw lesion. The aim of this study was to update the biological profile of AOT...
  11. Florescu A, Simionescu C, Ciurea R, Pitru A. P53, Bcl-2 and Ki67 immunoexpression in follicular solid ameloblastomas. Rom J Morphol Embryol. 2012;53:105-9 pubmed
    ..Squamous and granular cells reveal no stain for the investigated markers. Peripheral columnar cells are active compartment of ameloblastomas being involved in the processes of proliferation-apoptosis...
  12. Zemann W, Feichtinger M, Kowatsch E, Kärcher H. Extensive ameloblastoma of the jaws: surgical management and immediate reconstruction using microvascular flaps. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:190-6 pubmed
    ..The purpose of this study is to analyze the long-term functional and esthetic results after immediate reconstruction of large jaw defects using microvascular flaps...
  13. Kumamoto H, Ohki K. Detection of Notch signaling molecules in ameloblastomas. J Oral Pathol Med. 2008;37:228-34 pubmed publisher
    ..To evaluate the roles of Notch signaling in the oncogenesis and cytodifferentiation of odontogenic tumors, expression of Notch receptors and ligands was analyzed in ameloblastomas as well as in tooth germs...
  14. Ide F, Mishima K, Yamada H, Horie N, Saito I, Shimoyama T, et al. Unsuspected small ameloblastoma in the alveolar bone: a collaborative study of 14 cases with discussion of their cellular sources. J Oral Pathol Med. 2008;37:221-7 pubmed publisher
    ..Current information must lead to the consensus that IA arises from the embryologic inclusions of odontogenic epithelium within the jawbone. Nevertheless, clinically oriented evidence is limited to this day...
  15. Guadagnolo B, Zagars G, Raymond A, Benjamin R, Sturgis E. Osteosarcoma of the jaw/craniofacial region: outcomes after multimodality treatment. Cancer. 2009;115:3262-70 pubmed publisher
    ..The current study was performed to evaluate outcomes in patients with osteosarcoma of the head and neck (OHN) who were treated with surgery with or without radiotherapy (RT)...
  16. Siqueira A, Carvalho M, Monteiro A, Freitas V, Jaeger R, Pinheiro J. Matrix metalloproteinases, TIMPs and growth factors regulating ameloblastoma behaviour. Histopathology. 2010;57:128-37 pubmed publisher
    ..The aim was to study expression of MMPs, tissue inhibitor of metalloproteinases (TIMPs) and growth factors in ameloblastoma...
  17. Bodner L, Manor E, Shear M, van der Waal I. Primary intraosseous squamous cell carcinoma arising in an odontogenic cyst: a clinicopathologic analysis of 116 reported cases. J Oral Pathol Med. 2011;40:733-8 pubmed publisher
    ..To review the literature on primary intraosseous squamous cell carcinoma (PIOSCC) associated with odontogenic cyst...
  18. Vered M, Peleg O, Taicher S, Buchner A. The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but different from odontogenic cysts. J Oral Pathol Med. 2009;38:597-604 pubmed publisher
    ..Identification of mutations in the PTCH gene in some of the OKCs that were expected to produce truncated proteins, resulting in loss of control of the cell cycle, provided additional support for OKCs having a neoplastic nature...
  19. Zhang B, Zhang J, Huang H, Chen W, Tao Q, Zeng D, et al. Inhibition of ameloblastoma invasion in vitro and in vivo by inhibitor of metalloproteinase-2 activity. J Oral Pathol Med. 2009;38:731-6 pubmed publisher
    ..This study used matrix metalloproteinase-2 (MMP-2) inhibitor I (MMP-2I) to investigate the role played by MMP-2 activity in the local invasiveness of ameloblastoma...
  20. Zecha J, Mendes R, Lindeboom V, van der Waal I. Recurrence rate of keratocystic odontogenic tumor after conservative surgical treatment without adjunctive therapies - A 35-year single institution experience. Oral Oncol. 2010;46:740-2 pubmed publisher
  21. Ide F, Obara K, Yamada H, Mishima K, Saito I, Horie N, et al. Hamartomatous proliferations of odontogenic epithelium within the jaws: a potential histogenetic source of intraosseous epithelial odontogenic tumors. J Oral Pathol Med. 2007;36:229-35 pubmed
    ..Curiously, incipient tumors or possible precursor conditions of residual odontogenic epithelium have rarely been reported in the literature...
  22. Coleman H, Altini M, Ali H, Doglioni C, Favia G, Maiorano E. Use of calretinin in the differential diagnosis of unicystic ameloblastomas. Histopathology. 2001;38:312-7 pubmed
  23. Vered M, Shohat I, Buchner A. Epidermal growth factor receptor expression in ameloblastoma. Oral Oncol. 2003;39:138-43 pubmed
    ..Ameloblastoma is a locally aggressive tumor with possible lethal potential. Currently extensive surgery is the most acceptable treatment modality...
  24. Curran A, Damm D, Drummond J. Pathologically significant pericoronal lesions in adults: Histopathologic evaluation. J Oral Maxillofac Surg. 2002;60:613-7; discussion 618 pubmed
    ..This study reports the histopathologic diagnoses of a large series of pericoronal lesions in adults submitted to an oral and maxillofacial pathology biopsy service...
  25. Buchner A, Merrell P, Carpenter W. Relative frequency of central odontogenic tumors: a study of 1,088 cases from Northern California and comparison to studies from other parts of the world. J Oral Maxillofac Surg. 2006;64:1343-52 pubmed
    ..To determine the relative frequency of central odontogenic tumors in relation to all biopsy specimens and to one another in an oral pathology biopsy service and to compare the data with previous studies from different parts of the world...
  26. Jones A, Craig G, Franklin C. Range and demographics of odontogenic cysts diagnosed in a UK population over a 30-year period. J Oral Pathol Med. 2006;35:500-7 pubmed
    ..The aim of this study was to determine the range of all histologically diagnosed odontogenic cysts along with age range, sex distribution and site of presentation over a 30-year period...
  27. Altini M, Coleman H, Doglioni C, Favia G, Maiorano E. Calretinin expression in ameloblastomas. Histopathology. 2000;37:27-32 pubmed
    ..The objective of this study was to determine whether calretinin was expressed in the epithelium of ameloblastomas...
  28. Kumamoto H, Ooya K. Immunohistochemical detection of MT1-MMP, RECK, and EMMPRIN in ameloblastic tumors. J Oral Pathol Med. 2006;35:345-51 pubmed
  29. Granados R, Carrillo R, Najera L, Garcia Villanueva M, Patron M. Psammomatoid ossifying fibromas: immunohistochemical analysis and differential diagnosis with psammomatous meningiomas of craniofacial bones. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:614-9 pubmed
    ..To clarify the role of immunohistochemistry in the diagnosis of psammomatoid ossifying fibroma (PSOF), conventional cemento-ossifying fibroma (COF), and psammomatous meningioma (PM) of the craniofacial skeleton...
  30. Stoelinga P. The treatment of odontogenic keratocysts by excision of the overlying, attached mucosa, enucleation, and treatment of the bony defect with carnoy solution. J Oral Maxillofac Surg. 2005;63:1662-6 pubmed
  31. Yamaguchi S, Nagasawa H, Suzuki T, Fujii E, Iwaki H, Takagi M, et al. Sarcomas of the oral and maxillofacial region: a review of 32 cases in 25 years. Clin Oral Investig. 2004;8:52-5 pubmed
    ..Adequate excision with safety surgical margin as the initial therapy is important for better survival. The value of radiation therapy and/or chemotherapy is uncertain. The 5-year survival rate of primary cases was 61%...
  32. Ogunsalu C. Odontogenic tumours from two centres in Jamaica. A 15-year review. West Indian Med J. 2003;52:285-9 pubmed
    ..4%, a male). Of all these tumours, only ameloblastomas recurred. Further research is required to explain the high incidence of ameloblastoma, and why it has a predilection for people of low socioeconomic status in Jamaica...
  33. Kaban L, Troulis M, Ebb D, August M, Hornicek F, Dodson T. Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg. 2002;60:1103-11; discussion 1111-3 pubmed
    ..The purpose of this report is to present a treatment protocol consisting of enucleation, with preservation of vital structures, followed by subcutaneous interferon alpha...
  34. Myoung H, Hong S, Hong S, Lee J, Lim C, Choung P, et al. Odontogenic keratocyst: Review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:328-33 pubmed
    ..001). The histopathologic presence of one or more daughter cysts was significantly related to recurrence (P = .03)...
  35. Zhong M, Han Y, Wang J, Li Z, Bao G, Yue Y. [Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinase in ameloblastoma]. Shanghai Kou Qiang Yi Xue. 2003;12:427-31 pubmed
    ..To study the expression of matrix metalloproteinase(MMP) and tissue inhibitor of metalloproteinase (TIMP) in ameloblastoma (AB) and to determine the relationship between biological behavior of AB and clinical pathology...
  36. Regezi J. Odontogenic cysts, odontogenic tumors, fibroosseous, and giant cell lesions of the jaws. Mod Pathol. 2002;15:331-41 pubmed
    ..medical). Its relationship to giant cell tumor of long bone remains undetermined...
  37. Hayashi K, Tozaki M, Sugisaki M, Yoshida N, Fukuda K, Tanabe H. Dynamic multislice helical CT of ameloblastoma and odontogenic keratocyst: correlation between contrast enhancement and angiogenesis. J Comput Assist Tomogr. 2002;26:922-6 pubmed
    ..The correlation between enhancement characteristics and immunohistochemical findings, especially with regard to angiogenesis, was also evaluated...
  38. Takata T, Miyauchi M, Ogawa I, Kudo Y, Takekoshi T, Zhao M, et al. Immunoexpression of transforming growth factor beta in desmoplastic ameloblastoma. Virchows Arch. 2000;436:319-23 pubmed
    ..In the "hybrid" lesion, TGF-beta was not expressed in the area of follicular ameloblastoma but in that of DA. These results show that TGF-beta produced by tumor cells of DA plays a part in the desmoplastic matrix formation...
  39. Ladeinde A, Ajayi O, Ogunlewe M, Adeyemo W, Arotiba G, Bamgbose B, et al. Odontogenic tumors: a review of 319 cases in a Nigerian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:191-5 pubmed
    ..This study sought to determine the relative frequency of odontogenic tumors in a Nigerian population and to compare these data with previous reports...
  40. Chidzonga M, Mahomva L. Sarcomas of the oral and maxillofacial region: a review of 88 cases in Zimbabwe. Br J Oral Maxillofac Surg. 2007;45:317-8 pubmed
    ..There were 51 men (mean age 23 years) and 37 women (mean age 29). Forty-six tumours were in the mandible. Osteosarcoma accounted for 31 cases, and rhabdomyosarcoma 21 (usually under the age of 10 years)...
  41. Mosqueda Taylor A, Ledesma Montes C, Caballero Sandoval S, Portilla Robertson J, Ruiz Godoy Rivera L, Meneses Garcia A. Odontogenic tumors in Mexico: a collaborative retrospective study of 349 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84:672-5 pubmed
    ..7%), myxoma (17.7%), adenomatoid odontogenic tumor (7.1%), and calcifying odontogenic cyst (6.8%). Although relatively rare, odontogenic tumors are still an important cause of extensive surgical procedures in Mexico...
  42. Al Khateeb T, Al Hadi Hamasha A, Almasri N. Oral and maxillofacial tumours in north Jordanian children and adolescents: a retrospective analysis over 10 years. Int J Oral Maxillofac Surg. 2003;32:78-83 pubmed
    ..The majority of benign tumours in the young are probably developmental rather than true neoplasms...
  43. Kumamoto H, Yamauchi K, Yoshida M, Ooya K. Immunohistochemical detection of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in ameloblastomas. J Oral Pathol Med. 2003;32:114-20 pubmed
    ..To evaluate the roles of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in tumor progression, expression of MMP-1, -2 and -9 and TIMP-1 and -2 was analyzed in ameloblastomas as well as tooth germs...
  44. Dodds A, Cannon R, Suggs C, Wright J. mRNA expression and phenotype of odontogenic tumours in the v-Ha-ras transgenic mouse. Arch Oral Biol. 2003;48:843-50 pubmed
    ..The Tg.AC transgenic mouse carrying the v-Ha-ras oncogene has been found to spontaneously develop ameloblastoma-like tumours (35% by 1 year of age) that are rare in the wild type FVB background strain...
  45. Theodorou D, Theodorou S, Sartoris D. Primary non-odontogenic tumors of the jawbones: an overview of essential radiographic findings. Clin Imaging. 2003;27:59-70 pubmed
    ..Correct interpretation of the imaging features of lesions involving the jawbones suggests the diagnosis, aids in presurgical planning and improves patient management...
  46. Pinheiro J, Freitas V, Moretti A, Jorge A, Jaeger R. Local invasiveness of ameloblastoma. Role played by matrix metalloproteinases and proliferative activity. Histopathology. 2004;45:65-72 pubmed
    ..We also attempted to establish a relationship between the presence of MMPs and the proliferative activity of ameloblastoma cells...
  47. Adebayo E, Ajike S, Adekeye E. Tumours and tumour-like lesions of the oral and perioral structures of Nigerian children. Int J Oral Maxillofac Surg. 2001;30:205-8 pubmed
    ..4 to 1.0. Sites recorded were the jawbones, cheeks, gingival, forearm, testis and the spleen. The ratio of malignant lesions in Nigerian and African children appears to be higher than in the Caucasian population (2.4:1)...
  48. Lau S, Samman N. Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review. Int J Oral Maxillofac Surg. 2006;35:681-90 pubmed
    ..Enucleation alone resulted in the highest recurrence rate and treatment by marsupialization cannot be sufficiently evaluated since most cases were followed by a second stage surgery of some kind...
  49. Zhong M, Li Z, Wang J, Yue Y, Bao G. [The study of the invasive biologic behavior of ameloblastoma]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2004;39:45-8 pubmed
    ..To investigate the invasive biologic behavior of ameloblastoma (AB) and to analyze its correlative factors...
  50. Ogunlewe M, Ajayi O, Adeyemo W, Ladeinde A, James O. Osteogenic sarcoma of the jaw bones: a single institution experience over a 21-year period. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:76-81 pubmed
    ..The purpose of this article is to review cases of osteogenic sarcoma of the jaw bones diagnosed in our institution during a 21-year period...
  51. Kaplan I, Manor I, Yahalom R, Hirshberg A. Central giant cell granuloma associated with central ossifying fibroma of the jaws: a clinicopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;103:e35-41 pubmed
    ..To investigate the prevalence of clinical, radiographic, and histopathologic characteristics of combined central giant cell granuloma (CGCG) and central ossifying fibroma (COF)...
  52. Masi G, Barzon L, Iacobone M, Viel G, Porzionato A, Macchi V, et al. Clinical, genetic, and histopathologic investigation of CDC73-related familial hyperparathyroidism. Endocr Relat Cancer. 2008;15:1115-26 pubmed publisher
    ..This study also confirms that uterine involvement represents a clinical manifestation of the syndrome...
  53. Abe T, Maruyama S, Yamazaki M, Essa A, Babkair H, Mikami T, et al. Intramuscular keratocyst as a soft tissue counterpart of keratocystic odontogenic tumor: differential diagnosis by immunohistochemistry. Hum Pathol. 2014;45:110-8 pubmed publisher
    ..The results indicate that KCOT-like lesions can arise within soft tissues, although use of the term odontogenic might seem inappropriate in those cases. ..