Research Topics

Genomes and Genes

animal mammary neoplasms

Summary

Alias: mammary neoplasms, animal mammary carcinoma
Summary: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).

Webpages

  1. investigator: andrea mastro
    www.fred.psu.edu/ds/retrieve/fred/investigator/a36
  2. jonathan j. li - pharmacology, toxicology and therapeutics, university of kansas school of medicine
    www.kumc.edu/pharmacology/facstaff/li.html
  3. publication: osteopontin is a potential target gene in mouse mammary cancer chemoprevention by se-methylselenocysteine
    www.fred.psu.edu/ds/retrieve/fred/publication/15318939
  4. mesh descriptor: breast neoplasms
    www.fred.psu.edu/ds/retrieve/fred/meshdescriptor/D001943
  5. adenocarcinoma, mucinous
    buchta.lib.bioinfo.pl/meid:66507
  6. medline publication: elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cdna microarray
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/12844480
  7. autolysis
    buchta.lib.bioinfo.pl/meid:21328
  8. methylnitrosourea
    lib.bioinfo.pl/meid:45361

Publications

  1. Multiple functions of maspin in tumor progression and mouse development
    Ming Zhang
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, TX 77030, USA
    Front Biosci 9:2218-26
  2. Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression
    Dana M Brantley Sieders
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2363, USA
    FASEB J 19:1884-6
  3. Co-opted integrin signaling in ErbB2-induced mammary tumor progression
    Kermit L Carraway
    University of California, Davis, Cancer Center, Sacramento, California 95817, USA
    Cancer Cell 10:93-5
  4. p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells
    Seetharaman Balasenthil
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:1422-8
  5. RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland
    Elizabeth G Demicco
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Mol Cell Biol 25:10136-47
  6. Prolactin drives estrogen receptor-alpha-dependent ductal expansion and synergizes with transforming growth factor-alpha to induce mammary tumors in males
    Lisa M Arendt
    Cellular and Molecular Biology Program, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, WI 53706, USA
    Am J Pathol 172:194-202
  7. Protein kinase CK2 in mammary gland tumorigenesis
    E Landesman Bollag
    Department of Medicine, Boston Medical Center, Boston, Massachusetts, MA 02118 2394, USA
    Oncogene 20:3247-57
  8. Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium
    Hippokratis Kiaris
    Department of Cell Biology, Massachusetts General Hospital Center for Cancer Research, Department of Cell Biology, Harvard Medical School, 13th St, Bldg. 149, Charlestown, MA 02129, USA
    Am J Pathol 165:695-705
  9. Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes
    Jeannie E Maglione
    Department of Medicine, UCSD Cancer Center, School of Medicine, University of California-San Diego, La Jolla, CA, USA
    Mol Cancer Ther 3:941-53
  10. Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
    Glendon M Zinser
    Department of Surgery, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45267, USA
    Cancer Res 66:11967-74

Scientific Experts

Detail Information

Webpages9

  1. investigator: andrea mastro
    www.fred.psu.edu/ds/retrieve/fred/investigator/a36
  2. jonathan j. li - pharmacology, toxicology and therapeutics, university of kansas school of medicine
    www.kumc.edu/pharmacology/facstaff/li.html
  3. publication: osteopontin is a potential target gene in mouse mammary cancer chemoprevention by se-methylselenocysteine
    www.fred.psu.edu/ds/retrieve/fred/publication/15318939
  4. mesh descriptor: breast neoplasms
    www.fred.psu.edu/ds/retrieve/fred/meshdescriptor/D001943
  5. adenocarcinoma, mucinous
    buchta.lib.bioinfo.pl/meid:66507
  6. medline publication: elucidation of molecular targets of mammary cancer chemoprevention in the rat by organoselenium compounds using cdna microarray
    www.fred.psu.edu/ds/retrieve/fred/medlinepub/12844480
  7. autolysis
    buchta.lib.bioinfo.pl/meid:21328
  8. methylnitrosourea
    lib.bioinfo.pl/meid:45361

Publications62

  1. Multiple functions of maspin in tumor progression and mouse development
    Ming Zhang
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, TX 77030, USA
    Front Biosci 9:2218-26
    ..These data demonstrate that maspin not only plays a role in tumor progression and metastasis but also is a key regulatory molecule for normal mammary gland and embryonic development...
  2. Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression
    Dana M Brantley Sieders
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2363, USA
    FASEB J 19:1884-6
    ..These data suggest that host EphA2 receptor tyrosine kinase function is required in the tumor microenvironment for tumor angiogenesis and metastatic progression...
  3. Co-opted integrin signaling in ErbB2-induced mammary tumor progression
    Kermit L Carraway
    University of California, Davis, Cancer Center, Sacramento, California 95817, USA
    Cancer Cell 10:93-5
    ..These observations offer novel mechanistic insight into ErbB2 action and highlight the notion that ErbB2 co-opts the functions of other signaling proteins to elicit tumor progression...
  4. p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells
    Seetharaman Balasenthil
    Department of Molecular and Cellular Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:1422-8
    ....
  5. RelB/p52 NF-kappaB complexes rescue an early delay in mammary gland development in transgenic mice with targeted superrepressor IkappaB-alpha expression and promote carcinogenesis of the mammary gland
    Elizabeth G Demicco
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    Mol Cell Biol 25:10136-47
    ..Inhibition of RelB in breast cancer cells repressed cyclin D1 and c-Myc levels and growth in soft agar. These results implicate RelB/p52 complexes in mammary gland development and carcinogenesis...
  6. Prolactin drives estrogen receptor-alpha-dependent ductal expansion and synergizes with transforming growth factor-alpha to induce mammary tumors in males
    Lisa M Arendt
    Cellular and Molecular Biology Program, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Dr, Madison, WI 53706, USA
    Am J Pathol 172:194-202
    ..Activation of ER-alpha is one mechanism by which PRL may contribute to breast cancer and points to other therapeutic strategies for male patients...
  7. Protein kinase CK2 in mammary gland tumorigenesis
    E Landesman Bollag
    Department of Medicine, Boston Medical Center, Boston, Massachusetts, MA 02118 2394, USA
    Oncogene 20:3247-57
    ..Thus, in mice, rats, and humans, dysregulated expression of CK2 is associated with and is capable of contributing to mammary tumorigenesis. Targeted inhibition of CK2 could be useful in the treatment of breast cancer...
  8. Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium
    Hippokratis Kiaris
    Department of Cell Biology, Massachusetts General Hospital Center for Cancer Research, Department of Cell Biology, Harvard Medical School, 13th St, Bldg. 149, Charlestown, MA 02129, USA
    Am J Pathol 165:695-705
    ....
  9. Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomes
    Jeannie E Maglione
    Department of Medicine, UCSD Cancer Center, School of Medicine, University of California-San Diego, La Jolla, CA, USA
    Mol Cancer Ther 3:941-53
    ..These lines provide an opportunity to study the full range of events occurring secondary to PyV-mT expression in the mammary gland...
  10. Mammary-specific Ron receptor overexpression induces highly metastatic mammary tumors associated with beta-catenin activation
    Glendon M Zinser
    Department of Surgery, University of Cincinnati College of Medicine and Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45267, USA
    Cancer Res 66:11967-74
    ..These studies suggest that Ron overexpression may be a causative factor in breast tumorigenesis and provides a model to dissect the mechanism by which the Ron induces transformation and metastasis...
  11. Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy
    Shari A Price Schiavi
    Department of Cell Biology and Anatomy, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Cell Physiol 203:44-53
    ..These data provide further evidence of the ability of Muc4/SMC to interact with ErbB2 and influence its behavior in normal epithelia...
  12. IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo
    Peter K M Kim
    Department of Surgery, University of Pittsburgh Medical Center, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Oncogene 23:1125-35
    ..The mechanism of apoptosis may involve the transcriptional upregulation of bak, caspase-8, and caspase-7 expression. These data support the antitumor potential of IRF-1 and the use of agents that increase IRF-1 in breast cancer...
  13. Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells
    Ramanaiah Mamillapalli
    Section of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 283:24435-47
    ..Because PTHrP contributes to hypercalcemia and bone metastases, switching of G-protein usage by the CaR may contribute to the pathogenesis of breast cancer...
  14. Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland
    M J Bissell
    Division of Life Sciences, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA
    Biochem Soc Trans 35:18-22
    ....
  15. Integrin-linked kinase regulates osteopontin-dependent MMP-2 and uPA expression to convey metastatic function in murine mammary epithelial cancer cells
    Zhiyong Mi
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Carcinogenesis 27:1134-45
    ..In 4T1 murine mammary cancer cells, we conclude that OPN mediates metastatic behavior, in part, through upregulation of MMP-2 and uPA protein expression...
  16. Expression of gicerin enhances the invasive and metastatic activities of a mouse mammary carcinoma cell line
    Yasuhiro Tsukamoto
    Department of Veterinary Anatomy, Graduate School of Agricultural and Biological Sciences, Osaka Prefecture University, Osaka 599 8531, Japan
    Int J Oncol 23:1671-7
    ..The invasion of gicerin transfectants into the surrounding tissue was enhanced and severe metastasis to the lungs occurred. These findings suggest that gicerin is an effector for the malignant progression of mammary carcinoma...
  17. Imagable 4T1 model for the study of late stage breast cancer
    Kai Tao
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    BMC Cancer 8:228
    ..The new cell lines will greatly facilitate the study of late stage breast and preclinical assessment of cancer drugs and other therapeutics particularly those targeting immune system effects on tumor metastasis...
  18. Evaluation of accuracy of fine needle aspiration cytology for diagnosis of canine mammary tumours: comparative features with human tumours
    G D Cassali
    Laboratório de Patologia Comparada, Depto Patologia Geral ICB UFMG, Belo Horizonte, MG, Brazil
    Cytopathology 18:191-6
    ....
  19. Overexpression of an N-terminally truncated isoform of the nuclear receptor coactivator amplified in breast cancer 1 leads to altered proliferation of mammary epithelial cells in transgenic mice
    Maddalena T Tilli
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Research Building, Room E307, 3970 Reservoir Road, Washington, D C 20057, USA
    Mol Endocrinol 19:644-56
    ..These results are consistent with the hypothesis that the N-terminally deleted isoform of AIB1 can play a role in breast cancer development and/or progression...
  20. The role of C/EBPbeta in mammary gland development and breast cancer
    Sandra L Grimm
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Mammary Gland Biol Neoplasia 8:191-204
    ..Thus, C/EBPbeta appears to play a role in the specification of progenitor cell fate not only in the mammary gland, but also in a number of other tissues...
  21. Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis
    Natasza A Kurpios
    Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada
    J Mammary Gland Biol Neoplasia 8:177-90
    ..Taken together these observations suggest that the PEA3 subfamily proteins play key regulatory roles in both mammary gland development and oncogenesis...
  22. A role for the scaffolding adapter GAB2 in breast cancer
    Mohamed Bentires Alj
    Cancer Biology Program, Division of Hematology Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, NRB 1030, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 12:114-21
    ..Agents that target GAB2 or GAB2-dependent pathways may be useful for treating breast tumors that overexpress GAB2 or HER2 or both...
  23. Overexpression of activated murine Notch1 and Notch3 in transgenic mice blocks mammary gland development and induces mammary tumors
    Chunyan Hu
    Laboratory of Molecular Biology, Clinical Research Institute of Montréal, QC, Canada
    Am J Pathol 168:973-90
    ..Furthermore, MMTV/Notch3(intra) Tg mice exhibited a very similar phenotype. Thus, these Tg mice represent novel models for studying the role of Notch1 or Notch3 in the development and transformation of the mammary gland...
  24. The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis
    Aijin Wang
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Smithville, TX, USA
    BMC Cancer 8:268
    ..A subset of human breast tumors expresses high levels of ATF3, suggesting that ATF3 may play an oncogenic role in human breast tumorigenesis, and therefore may be useful as either a biomarker or therapeutic target...
  25. Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice
    Elena Iavnilovitch
    Institute of Animal Science, Agricultural Research Organization, Volcani Center, Bet-Dagan, Israel
    Int J Cancer 112:607-19
    ..The transactivation function of Stat5 is involved in the determination of tumors with a more differentiated phenotype...
  26. Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice
    Shixia Huang
    Program in Cancer Biology and Genetics, Sloan Kettering Institute, New York, NY 10021, USA
    Genome Biol 6:R84
    ..The expression data developed provide a resource for illuminating the molecular mechanisms involved in breast cancer development, especially through the identification of genes that are critical in cancer initiation and progression...
  27. The role of X-linked genes in breast cancer
    Archana Thakur
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
    Breast Cancer Res Treat 93:135-43
    ..Increased understanding of the role of X-linked genes and genetic pathways will provide the strategies to develop the molecular therapeutics to treat and prevent reproductive related cancers...
  28. Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells
    Aeree Kim
    Department of Pathology and College of Medicine, Oklahoma University Health Sciences Center OUHSC, Oklahoma City, OK, USA
    Breast Cancer Res 7:R708-18
    ..These data strongly suggest a role for erbB3 in c-neu (ErbB2)-associated mammary tumorigenesis, as has been reported in human breast cancers...
  29. Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia
    D S Salomon
    Tumor Factor Growth Section, LTIB, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Bioessays 21:61-70
    ..Taken together, this evidence suggests that Cr-1/CR-1 performs a role in normal mammary gland development and that it might contribute to the early stages of mouse mammary tumorigenesis and the pathobiology of human breast cancer...
  30. EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 283:3433-44
    ..Reciprocal changes in the interaction between BRCA1, p300, and the aromatase promoter I.3/II contributed to the inductive effects of PGE(2)...
  31. Of mice and Myc: c-Myc and mammary tumorigenesis
    M Hunter Jamerson
    Department of Oncology and Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA
    J Mammary Gland Biol Neoplasia 9:27-37
    ....
  32. Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist
    Aleksandra Jovanovic Poole
    Department of Biological Chemistry, University of California, Irvine, CA 92697 4037, USA
    Science 314:1467-70
    ..These findings reveal a tissue-specific function for the BRCA1 protein and raise the possibility that antiprogesterone treatment may be useful for breast cancer prevention in individuals with BRCA1 mutations...
  33. NF-kappaB in mammary gland development and breast cancer
    Yixue Cao
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Mammary Gland Biol Neoplasia 8:215-23
    ..Elevated NF-kappaB DNA-binding activity is detected in both mammary carcinoma cell lines and primary human breast cancer tissues...
  34. Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor
    Conor C Lynch
    Department of Cancer Biology, Vanderbilt University, 23rd and Pierce Avenue, Nashville, TN 37232, USA
    Cancer Res 67:6760-7
    ..Furthermore, overexpression of the ErbB4 ICD in the c57MG cell line recapitulated the proliferative effects of MMP7 in vitro and in vivo. These data indicate a novel mechanism for mammary epithelial cell transformation by MMP7...
  35. Protein kinase CK2: signaling and tumorigenesis in the mammary gland
    E Landesman Bollag
    Department of Pathology, Boston University School of Medicine, MA 02118, USA
    Mol Cell Biochem 227:153-65
    ..Thus, CK2 may promote breast cancer through dysregulation of key pathways of transcriptional control in the mammary epithelium, and inhibition of CK2 has a potential role in the treatment of breast and other cancers...
  36. ErbB2 is required for ductal morphogenesis of the mammary gland
    Amy J Jackson Fisher
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Proc Natl Acad Sci U S A 101:17138-43
    ..Lobuloalveolar development was not affected in glands that developed from ErbB2(-/-) transplanted tissue. The results may have implications for the aggressive phenotypes associated with ERBB2-overexpressing mammary carcinomas...
  37. Role of GTP-binding proteins in reversing the antiproliferative effects of tocotrienols in preneoplastic mammary epithelial cells
    Paul W Sylvester
    College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209 0470, USA
    Asia Pac J Clin Nutr 11:S452-9
    ....
  38. Delta N89 beta-catenin induces precocious development, differentiation, and neoplasia in mammary gland
    A Imbert
    Department of Cell Biology, New York University Medical School, New York, New York 10016, USA
    J Cell Biol 153:555-68
    ..In particular, Delta N 89 beta-catenin has no effect on ductal side branching. This suggests that Wnt induction of ductal branching involves additional downstream effectors or modulators...
  39. Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis
    Shiquan Liu
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892-4264, USA
    Proc Natl Acad Sci U S A 99:3770-5
    ....
  40. Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice
    Alison M Y Cheung
    Advanced Medical Discovery Institute, University Health Network, 620 University Avenue, Suite 706, Toronto, Ontario M5G 2C1, Canada
    Cancer Res 64:1959-65
    ..Our data indicate that Brca2 is not essential for mammary epithelium development but that Brca2 deficiency and down-regulated p53 expression can work jointly to promote mammary tumorigenesis...
  41. NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice
    I M Krane
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Oncogene 12:1781-8
    ..Additionally, about 50% of MMTV-NDF transgenic mice developed Harderian (lachrymal) gland hyperplasia, a benign tumor that does not progress to frank malignancy...
  42. Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
    Terence M Williams
    Department of Molecular Pharmacology and Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 279:51630-46
    ..These results demonstrate, for the first time, that caveolin-1 is a potent suppressor of mammary tumor growth and metastasis using novel in vivo animal model approaches...
  43. Transforming growth factor-alpha promotes mammary tumorigenesis through selective survival and growth of secretory epithelial cells
    G H Smith
    Laboratory of Tumor Immunology and Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
    Am J Pathol 147:1081-96
    ..These points support the notion that TGF-alpha can act as a mitogen and also as a differentiation factor in mammary epithelium...
  44. Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma
    Christian Wechselberger
    Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    Oncogene 24:4094-105
    ..This is the first in vivo study that shows hyperplasia and tumor growth in CR-1-overexpressing animals...
  45. Hox genes in normal and neoplastic mouse mammary gland
    Y Friedmann
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064
    Cancer Res 54:5981-5
    ..In contrast, Hoxa-1 was expressed only in cancers, not in normal gland or in precancerous mammary tissues, suggesting that Hox genes may play a role in a late stage in the stepwise development of mammary malignancies...
  46. The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis
    Azadeh Golipour
    Department of Biological Sciences, University of Windsor Ontario, Windsor, Ontario, Canada
    Cancer Res 68:3591-600
    ..Collectively, this work is the first report that the Spy1/RINGO family of proteins may play an essential role in regulating both normal and abnormal growth processes in the breast...
  47. Role of homeobox genes in normal mammary gland development and breast tumorigenesis
    Hexin Chen
    Breast Cancer Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA
    J Mammary Gland Biol Neoplasia 8:159-75
    ..Recent studies of homeobox genes in breast cancer cells and primary tumors indicate that they may also play a contributory or causal role in tumorigenesis by regulating the cell cycle, apoptosis, angiogenesis, and/or metastasis...
  48. Anti-EphA2 antibodies decrease EphA2 protein levels in murine CT26 colorectal and human MDA-231 breast tumors but do not inhibit tumor growth
    David Kiewlich
    Corporate Research Oncology, Berlex Biosciences, Richmond, CA 94804, USA
    Neoplasia 8:18-30
    ..These results suggest that molecular characteristics of the tumors in addition to EphA2 over-expression may be important for predicting responsiveness to EphA2-directed therapies...
  49. Establishment and characterization of new mammary adenocarcinoma cell lines derived from double transgenic mice expressing GFP and neu oncogene
    M G Sacco
    Human Genome Department, ITB CNR, Segrate Italy
    Cell Prolif 39:611-22
    ....
  50. An actin-binding protein Girdin regulates the motility of breast cancer cells
    Ping Jiang
    Department of Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 68:1310-8
    ..These findings highlight the important role of Girdin in tumor progression in which the Akt signaling pathway is aberrantly activated...
  51. Ag-specific type 1 CD8 effector cells enhance methotrexate-mediated antitumor responses by modulating endogenous CD49b-expressing CD4 and CD8 T effector cell subpopulations producing IL-10
    Mark J Dobrzanski
    Department of Internal Medicine, Texas Tech University School of Medicine, Amarillo, Texas 79106, USA
    Immunol Invest 37:315-38
    ..Supplementary materials are available for this article. Go to the publisher's online edition of Immunological Investigations for the following free supplemental resource(s): Addendum 1...
  52. Antimetastatic activity of a preventive cancer vaccine
    Patrizia Nanni
    Section of Cancer Research, University of Bologna, Bologna, Italy
    Cancer Res 67:11037-44
    ....
  53. Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model
    Toru Hiraga
    Department of Biochemistry, Graduate School of Dentistry, Osaka University, Suita, Osaka, Japan
    Clin Cancer Res 10:4559-67
    ..These effects of ZOL may be attributable to inhibition of migration and invasion of breast cancer cells. Clinical relevance of our experimental results needs to be determined in breast cancer patients with visceral metastases...
  54. Vascular endothelial cadherin promotes breast cancer progression via transforming growth factor beta signaling
    Myriam Labelle
    Institute of Pathology, University of Dresden, Dresden, Germany
    Cancer Res 68:1388-97
    ..Our findings may have important implications for the clinical application of anti-VE-cadherin strategies...
  55. Tumor-derived CCL5 does not contribute to breast cancer progression
    Mevan M Jayasinghe
    Department Biology, Lafayette College, Easton, PA 18042, USA
    Breast Cancer Res Treat 111:511-21
    ..These results show that tumor-derived CCL5 expression alone does not make a significant contribution to breast cancer progression...
  56. Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand
    Thomas J Wilson
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5845, USA
    Cancer Res 68:5803-11
    ....
  57. Multistep mouse mammary tumorigenesis through pre-neoplasia to neoplasia and acquisition of metastatic potential
    Airo Tsubura
    Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Med Mol Morphol 40:9-17
    ..In the present review article, we describe morphological, biological, and molecular aspects of premalignant lesions of mice, and we discuss their metastatic phenotypes...
  58. Evaluation of telomerase in canine mammary tissues by immunohistochemical analysis and a polymerase chain reaction-based enzyme-linked immunosorbent assay
    Serena Panarese
    Department of Veterinary Public Health and Animal Pathology, Section of General Pathology and Pathologic Anatomy, Faculty of Veterinary Medicine, University of Bologna Via Tolara di Sopra, 50-40064, Ozzano dell'Emilia, Bologna, Italy
    J Vet Diagn Invest 18:362-8
    ..The detection of telomerase in normal mammary gland and fibrocystic mastopathy using both methods does not support the idea that telomerase may be used as a specific marker of mammary neoplasia in dogs...
  59. Immunohistochemical expression of protein p53 in neoplasms of the mammary gland in bitches
    A Rodo
    Warsaw University of Life Sciences, Faculty of Veterinary Medicine, Department of Clinical Sciences, Warsaw, Poland
    Pol J Vet Sci 11:89-95
    ..Higher accumulation of protein p53 in more malignant neoplasms suggests that mutations of protein p53 can be responsible for higher proliferation in neoplasms with advanced progression of malignancy...
  60. The expression of sialyl Lewis X in canine and feline mammary gland tumors
    Takayuki Nakagawa
    Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 64:949-52
    ..However, its expression was not correlated with clinicopathological features and prognosis significantly. This study suggests that sLe(x) may be a tumor-associated antigen in canine and feline MGTs...
  61. Expression and significance of PTEN in canine mammary gland tumours
    Changwei Qiu
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, China
    Res Vet Sci 85:383-8
    ..Low-level PETN expression might play an important role in carcinogenesis and the progression of canine mammary tumours, and PTEN protein detection might be useful in evaluating tumour development and prognosis...
  62. cDNA microarray profiles of canine mammary tumour cell lines reveal deregulated pathways pertaining to their phenotype
    N A S Rao
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
    Anim Genet 39:333-45
    ..In addition these cell lines can be used to further investigate identified deregulated pathways and characterize until now unannotated genes...