animal mammary neoplasms


Summary: Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).

Top Publications

  1. Uva P, Aurisicchio L, Watters J, Loboda A, Kulkarni A, Castle J, et al. Comparative expression pathway analysis of human and canine mammary tumors. BMC Genomics. 2009;10:135 pubmed publisher
  2. Antuofermo E, Miller M, Pirino S, Xie J, Badve S, Mohammed S. Spontaneous mammary intraepithelial lesions in dogs--a model of breast cancer. Cancer Epidemiol Biomarkers Prev. 2007;16:2247-56 pubmed
  3. Genelhu M, Cardoso S, Gobbi H, Cassali G. A comparative study between mixed-type tumours from human salivary and canine mammary glands. BMC Cancer. 2007;7:218 pubmed
    ..The aim of the study was to compare clinical, morphological and immunohistochemical features of human salivary and canine mammary gland mixed tumours, in order to evaluate the latter as an experimental model for salivary gland tumours...
  4. Gama A, Alves A, Schmitt F. Identification of molecular phenotypes in canine mammary carcinomas with clinical implications: application of the human classification. Virchows Arch. 2008;453:123-32 pubmed publisher
  5. Klopfleisch R, Gruber A. Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas. Vet Pathol. 2009;46:416-22 pubmed publisher
    ..Further experimental studies are needed to clarify whether these changes in gene expression are a direct carcinogenetic stimulus or a protective response due to genetic instability during tumor progression...
  6. Bertagnolli A, Cassali G, Genelhu M, Costa F, Oliveira J, Gonçalves P. Immunohistochemical expression of p63 and deltaNp63 in mixed tumors of canine mammary glands and its relation with p53 expression. Vet Pathol. 2009;46:407-15 pubmed publisher
    ..Our data support the notion that the decrease of p63 expression, in particular of its isoform DeltaNp63, seems to be an important factor in the development of carcinomas in mixed tumors...
  7. Kuraguchi M, Ohene Baah N, Sonkin D, Bronson R, Kucherlapati R. Genetic mechanisms in Apc-mediated mammary tumorigenesis. PLoS Genet. 2009;5:e1000367 pubmed publisher
  8. Provenzano P, Inman D, Eliceiri K, Knittel J, Yan L, Rueden C, et al. Collagen density promotes mammary tumor initiation and progression. BMC Med. 2008;6:11 pubmed publisher
    ..Importantly, regions of high breast density are associated with increased stromal collagen. Thus, the influence of the extracellular matrix on breast carcinoma development and the underlying molecular mechanisms are not understood...
  9. Simon D, Schoenrock D, Nolte I, Baumgartner W, Barron R, Mischke R. Cytologic examination of fine-needle aspirates from mammary gland tumors in the dog: diagnostic accuracy with comparison to histopathology and association with postoperative outcome. Vet Clin Pathol. 2009;38:521-8 pubmed publisher
    ..Malignant tumors may carry a poor prognosis and necessitate surgery. Few data are available on the value of cytologic examination as a diagnostic or prognostic tool for mammary tumors in dogs...

More Information


  1. Klopfleisch R, Schutze M, Gruber A. Loss of p27 expression in canine mammary tumors and their metastases. Res Vet Sci. 2010;88:300-3 pubmed publisher
  2. Gravekamp C, Leal B, Denny A, Bahar R, Lampkin S, Castro F, et al. In vivo responses to vaccination with Mage-b, GM-CSF and thioglycollate in a highly metastatic mouse breast tumor model, 4T1. Cancer Immunol Immunother. 2008;57:1067-77 pubmed
    ..Whether the interaction between Fas and FasL may have contributed to the smaller tumors needs to be further analyzed...
  3. Cariati M, Naderi A, Brown J, Smalley M, Pinder S, Caldas C, et al. Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line. Int J Cancer. 2008;122:298-304 pubmed
    ..These findings support the existence of a highly tumourigenic sub-population in breast cancer cells. Furthermore, it shows alpha6-integrin as a potential therapeutic target aimed at tumour-generating subsets of breast cancer cells...
  4. Grange C, Lanzardo S, Cavallo F, Camussi G, Bussolati B. Sca-1 identifies the tumor-initiating cells in mammary tumors of BALB-neuT transgenic mice. Neoplasia. 2008;10:1433-43 pubmed
    ..The data of the present study indicate that a Sca-1(+) population derived from mammary BALB-neuT tumors is responsible for sphere generation in culture and for initiating tumors in vivo...
  5. Firlej V, Ladam F, Brysbaert G, Dumont P, Fuks F, De Launoit Y, et al. Reduced tumorigenesis in mouse mammary cancer cells following inhibition of Pea3- or Erm-dependent transcription. J Cell Sci. 2008;121:3393-402 pubmed publisher
  6. Klopfleisch R, Gruber A. Differential expression of cell cycle regulators p21, p27 and p53 in metastasizing canine mammary adenocarcinomas versus normal mammary glands. Res Vet Sci. 2009;87:91-6 pubmed publisher
    ..Taken together the results suggest that loss of p21 overexpression is associated with tumor metastasis while reduced cell cycle inhibition by p27 is associated with malignant progression...
  7. Hebbard L, Garlatti M, Young L, Cardiff R, Oshima R, Ranscht B. T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res. 2008;68:1407-16 pubmed publisher
  8. Munson L, Moresco A. Comparative pathology of mammary gland cancers in domestic and wild animals. Breast Dis. 2007;28:7-21 pubmed
    ..Overall, spontaneous mammary cancers in cats and dogs make excellent models for human breast cancer, and knowledge of mammary carcinogenesis would be greatly enhanced across all species by a "One Medicine" approach...
  9. Eilon T, Barash I. Different gene-expression profiles for the poorly differentiated carcinoma and the highly differentiated papillary adenocarcinoma in mammary glands support distinct metabolic pathways. BMC Cancer. 2008;8:270 pubmed publisher
    ..To distinguish the genes and elucidate the cellular processes and metabolic pathways utilized to preserve these phenotypes, gene-expression profiles were analyzed...
  10. Li Z, Tognon C, Godinho F, Yasaitis L, Hock H, Herschkowitz J, et al. ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 2007;12:542-58 pubmed
    ..Given the increasing relevance of chromosomal translocations in epithelial cancers, such mice serve as a paradigm for the study of their genetic pathogenesis and cellular origins, and generation of preclinical models...
  11. Wensman H, Flama V, Pejler G, Hellmen E. Plasticity of cloned canine mammary spindle cell tumor, osteosarcoma and carcinoma cells. Vet Pathol. 2008;45:803-15 pubmed publisher
    ..Our results point to plasticity in canine mammary tumors, as shown both by morphologic criteria and by expression patterns for lineage specific markers...
  12. Li H, Dutuor A, Fu X, Zhang X. Induction of strong antitumor immunity by an HSV-2-based oncolytic virus in a murine mammary tumor model. J Gene Med. 2007;9:161-9 pubmed
    ..We conclude that the HSV-2-based FusOn-H2 oncolytic virus may be an effective agent for the treatment of both primary and metastatic breast cancer...
  13. Smith G. Stem cells and mammary cancer in mice. Stem Cell Rev. 2005;1:215-23 pubmed
    ..Retroviral marking via MMTV proviral insertion demonstrates that this process progresses from a single mammary epithelial cell that possesses all the features ascribed to tissue-specific stem cells...
  14. Rajkumar L, Kittrell F, Guzman R, Brown P, Nandi S, Medina D. Hormone-induced protection of mammary tumorigenesis in genetically engineered mouse models. Breast Cancer Res. 2007;9:R12 pubmed
    ..The experiments reported here address the question of whether a short-term hormone treatment can prevent mammary tumorigenesis in two different genetically engineered mouse models...
  15. Dupré S, Redelman D, Hunter K. The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci. Int J Exp Pathol. 2007;88:351-60 pubmed
    ..This pathologic presentation correlated with the expression of tumour-derived chemokines...
  16. Wang Y, Lam K, Xu A. Adiponectin as a negative regulator in obesity-related mammary carcinogenesis. Cell Res. 2007;17:280-2 pubmed
  17. Cassali G, Gobbi H, Malm C, Schmitt F. Evaluation of accuracy of fine needle aspiration cytology for diagnosis of canine mammary tumours: comparative features with human tumours. Cytopathology. 2007;18:191-6 pubmed
  18. Huang S, Podsypanina K, Chen Y, Cai W, Tsimelzon A, Hilsenbeck S, et al. Wnt-1 is dominant over neu in specifying mammary tumor expression profiles. Technol Cancer Res Treat. 2006;5:565-71 pubmed
    ..These observations suggest that Wnt-1 is dominant over Neu in specifying mammary tumor expression profiles...
  19. Lindvall C, Evans N, Zylstra C, Li Y, Alexander C, Williams B. The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis. J Biol Chem. 2006;281:35081-7 pubmed
    ..These findings suggest that Lrp5-mediated canonical signaling is required for mammary ductal stem cell activity and for tumor development in response to oncogenic Wnt effectors...
  20. Lindvall C, Bu W, Williams B, Li Y. Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell Rev. 2007;3:157-68 pubmed
  21. Pinho S, Matos A, Lopes C, Marcos N, Carvalheira J, Reis C, et al. Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression. BMC Cancer. 2007;7:124 pubmed
    ..The aim of this study was to analyse the sLex expression in canine malignant mammary tumours and to evaluate if the presence of sLex correlates with the expression of E-Cadherin and with clinicopathological features...
  22. Samant G, Sylvester P. gamma-Tocotrienol inhibits ErbB3-dependent PI3K/Akt mitogenic signalling in neoplastic mammary epithelial cells. Cell Prolif. 2006;39:563-74 pubmed
  23. Murray T, Maffini M, Ucci A, Sonnenschein C, Soto A. Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure. Reprod Toxicol. 2007;23:383-90 pubmed
    ..Thus, fetal bisphenol A exposure is sufficient to induce the development of preneoplastic and neoplastic lesions in the mammary gland in the absence of any additional treatment aimed at increasing tumor development...
  24. Jarrar M, Baranova A. PPARgamma activation by thiazolidinediones (TZDs) may modulate breast carcinoma outcome: the importance of interplay with TGFbeta signalling. J Cell Mol Med. 2007;11:71-87 pubmed
    ..In this review, we dissect possible interplays between chronic exposure of breast tis-sue to TZDs and TGFbeta signalling and predict influence of TZD exposure on cancer-related clinical outcome...
  25. Gama A, Paredes J, Gartner F, Alves A, Schmitt F. Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival. Vet J. 2008;177:45-53 pubmed
    ..Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression...
  26. Wali V, Sylvester P. Synergistic antiproliferative effects of gamma-tocotrienol and statin treatment on mammary tumor cells. Lipids. 2007;42:1113-23 pubmed
  27. Klopfleisch R, Klose P, Gruber A. The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors. Vet Pathol. 2010;47:446-54 pubmed publisher
    ..This pilot study identified a complex mRNA expression pattern of 3 genes that was able to identify malignancy in laser-microdissected tumor cells for each individual tumor, instead of group means as used in previous studies. ..
  28. Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, et al. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009;28:2763-76 pubmed publisher
    ..These findings may shed new light on the EGFR-related breast carcinogenesis and might offer a potential new target for breast cancer therapy. ..
  29. Moral R, Solanas M, Garcia G, Grau L, Vela E, Escrich R, et al. High corn oil and high extra virgin olive oil diets have different effects on the expression of differentiation-related genes in experimental mammary tumors. Oncol Rep. 2008;20:429-35 pubmed
    ..The modulation of transferrin and ZBP1 expression by the high olive oil and the high corn oil diets could be one of the mechanisms by which such diets have a different influence on mammary carcinogenesis. ..
  30. Paoli E, Kruse D, Seo J, Zhang H, Kheirolomoom A, Watson K, et al. An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation. J Control Release. 2010;143:13-22 pubmed publisher
    ..95 and R(2)=0.99 respectively. We demonstrate that the accumulation of a hydrophilic model drug is increased by up to 177 fold by liposomal encapsulation, as compared to accumulation of the drug at 24 hours. ..
  31. Santos S, Sá D, Bastos E, Guedes Pinto H, Gut I, Gartner F, et al. An efficient protocol for genomic DNA extraction from formalin-fixed paraffin-embedded tissues. Res Vet Sci. 2009;86:421-6 pubmed publisher
    ..The DNA fragments obtained were further sequenced. This protocol was able to provide FFPET gDNA that can be amplified and sequenced for larger fragments up to 1182bp. ..
  32. Yazdi M, Soltan Dallal M, Hassan Z, Holakuyee M, Agha Amiri S, Abolhassani M, et al. Oral administration of Lactobacillus acidophilus induces IL-12 production in spleen cell culture of BALB/c mice bearing transplanted breast tumour. Br J Nutr. 2010;104:227-32 pubmed publisher
    ..But further studies are needed to find out some other possible mechanisms of this effect. ..
  33. Morecki S, Yacovlev E, Gelfand Y, Shabat Y, Slavin S. Induction of graft-versus-leukemia (GVL) effect without graft-versus-host disease (GVHD) by pretransplant donor treatment with immunomodulators. Biol Blood Marrow Transplant. 2009;15:406-15 pubmed publisher
  34. Zavlaris M, Angelopoulou K, Vlemmas I, Papaioannou N. Telomerase reverse transcriptase (TERT) expression in canine mammary tissues: a specific marker for malignancy?. Anticancer Res. 2009;29:319-25 pubmed
  35. Woldemeskel M, Rajeev S. Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors. Vet Res Commun. 2010;34:153-60 pubmed publisher
    ..Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended...
  36. Hynes N, Watson C. Mammary gland growth factors: roles in normal development and in cancer. Cold Spring Harb Perspect Biol. 2010;2:a003186 pubmed publisher
    ..We will discuss different peptides in the context of normal development and cancer in this review. ..
  37. Samei E, Saunders R, Badea C, Ghaghada K, Hedlund L, Qi Y, et al. Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent. Int J Nanomedicine. 2009;4:277-82 pubmed
    ..The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies. ..
  38. Anisimov V, Egormin P, Piskunova T, Popovich I, Tyndyk M, Yurova M, et al. Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo. Cell Cycle. 2010;9:188-97 pubmed
    ..001). The combined treatment with metformin + melatonin significantly suppressed Ehrlich tumor growth (by 40%, p < 0.001). These results suggest that metformin may be useful in prevention and treatment of breast cancer. ..
  39. Palha De Sousa C, Blum C, Sgroe E, Crespo A, Kurt R. Murine mammary carcinoma cells and CD11c(+) dendritic cells elicit distinct responses to lipopolysaccharide and exhibit differential expression of genes required for TLR4 signaling. Cell Immunol. 2010;266:67-75 pubmed publisher
    ..Thus, carcinoma and DC are distinctly responsive to LPS. ..
  40. Punathil T, Tollefsbol T, Katiyar S. EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase. Biochem Biophys Res Commun. 2008;375:162-7 pubmed publisher
    ..These results indicate for the first time that EGCG inhibits mammary cancer cell migration through the inhibition of NO/NOS and guanylate cyclase. ..
  41. Nakagawa K, Miyagawa Y, Takemura N, Hirose H. Influence of preemptive analgesia with meloxicam before resection of the unilateral mammary gland on postoperative cardiovascular parameters in dogs. J Vet Med Sci. 2007;69:939-44 pubmed
    ..This study showed that perioperative administration of meloxicam reduced unfavorable postoperative changes in the cardiovascular system without influencing renal function. ..
  42. Faley S, Takahashi K, Crooke C, Beckham J, Tomemori T, Shappell S, et al. Bioluminescence imaging of vascular endothelial growth factor promoter activity in murine mammary tumorigenesis. Mol Imaging. 2007;6:331-9 pubmed
    ..The model should facilitate understanding of the molecular controls and pathways that regulate VEGF transcription in vivo. ..
  43. Queiroga F, Pires I, Lobo L, Lopes C. The role of Cox-2 expression in the prognosis of dogs with malignant mammary tumours. Res Vet Sci. 2010;88:441-5 pubmed publisher
    ..For Cox-1 expression, no statistically significant association was observed. Present study suggests the usefulness of testing Cox-2 specific inhibitors as part of an adjuvant therapy in female dogs with malignant mammary neoplasias...
  44. Herve M, Buteau Lozano H, Vassy R, Bieche I, Velasco G, Pla M, et al. Overexpression of vascular endothelial growth factor 189 in breast cancer cells leads to delayed tumor uptake with dilated intratumoral vessels. Am J Pathol. 2008;172:167-78 pubmed
    ..Whether VEGF189 overexpression is correlated to prognosis in human breast tumors remains to be established. ..
  45. Paltian V, Alldinger S, Baumgartner W, Wohlsein P. Expression of CD44 in canine mammary tumours. J Comp Pathol. 2009;141:237-47 pubmed publisher
    ..Up-regulation of CD44 therefore appears to be associated with benign or relatively benign biological behaviour of canine mammary tumours. ..
  46. Ali H, Shirode A, Sylvester P, Nazzal S. Preparation, characterization, and anticancer effects of simvastatin-tocotrienol lipid nanoparticles. Int J Pharm. 2010;389:223-31 pubmed publisher
    ..7 microM whereas the IC(50) of the simvastatin/TRF nanoparticles was 0.52 microM, which confirmed the potency of the combined treatment and its potential in cancer therapy. ..
  47. Jayasinghe M, Golden J, Nair P, O Donnell C, Werner M, Kurt R. Tumor-derived CCL5 does not contribute to breast cancer progression. Breast Cancer Res Treat. 2008;111:511-21 pubmed
    ..These results show that tumor-derived CCL5 expression alone does not make a significant contribution to breast cancer progression. ..
  48. Rodo A, Malicka E. E-cadherin immunohistochemical expression in mammary gland neoplasms in bitches. Pol J Vet Sci. 2008;11:47-54 pubmed
    ..The study has shown that the expression of E-cadherin can be used as a prognostic factor. ..
  49. Tognolini A, Schor Bardach R, Pianykh O, Wilcox C, Raptopoulos V, Goldberg S. Body tumor CT perfusion protocols: optimization of acquisition scan parameters in a rat tumor model. Radiology. 2009;251:712-20 pubmed publisher
    ..Scanning the aortic reference with peak contrast enhancement reduces variability sufficiently to allow for longer ISDs. ..
  50. Clemente M, Perez Alenza M, Pena L. Metastasis of canine inflammatory versus non-inflammatory mammary tumours. J Comp Pathol. 2010;143:157-63 pubmed publisher
    ..These data have clinical relevance and the observations may have value in consideration of the fact that canine IMC has been proposed as a natural model for the study of human inflammatory breast cancer. ..
  51. Kim J, Yu C, Yhee J, Im K, Sur J. Lymphocyte infiltration, expression of interleukin (IL) -1, IL-6 and expression of mutated breast cancer susceptibility gene-1 correlate with malignancy of canine mammary tumours. J Comp Pathol. 2010;142:177-86 pubmed publisher
    ..There was an association between the expression of TILs, cytokines and mutation of BRCA1, suggesting that all of these factors may play a role in tumour progression. ..
  52. Ray D, Kiyokawa H. CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability. Cancer Res. 2008;68:1251-3 pubmed publisher
    ..These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy. ..
  53. Tao K, Fang M, Alroy J, Sahagian G. Imagable 4T1 model for the study of late stage breast cancer. BMC Cancer. 2008;8:228 pubmed publisher
    ..The new cell lines will greatly facilitate the study of late stage breast and preclinical assessment of cancer drugs and other therapeutics particularly those targeting immune system effects on tumor metastasis. ..
  54. Messina M, Wu A. Perspectives on the soy-breast cancer relation. Am J Clin Nutr. 2009;89:1673S-1679S pubmed publisher
  55. Seagroves T, Peacock D, Liao D, Schwab L, Krueger R, Handorf C, et al. VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis. Am J Pathol. 2010;176:2269-82 pubmed publisher
    ..These results suggest that additional VHL-regulated genes besides HIF1A function to maintain the proliferative and regenerative potential of the breast epithelium...
  56. de M Souza C, Toledo Piza E, Amorin R, Barboza A, Tobias K. Inflammatory mammary carcinoma in 12 dogs: clinical features, cyclooxygenase-2 expression, and response to piroxicam treatment. Can Vet J. 2009;50:506-10 pubmed
    ..In conclusion, piroxicam should be considered as a single agent for the treatment of dogs with inflammatory mammary carcinoma...
  57. Dias Pereira P, Lopes C, Matos A, Pinto D, Gartner F, Lopes C, et al. Influence of catechol-O-methyltransferase (COMT) genotypes on the prognosis of canine mammary tumors. Vet Pathol. 2009;46:1270-4 pubmed publisher
    ..Identifying a genetic factor predictive of recurrence may be useful in selecting the most effective surgical approach for canine mammary neoplasms...
  58. Millanta F, Caneschi V, Ressel L, Citi S, Poli A. Expression of vascular endothelial growth factor in canine inflammatory and non-inflammatory mammary carcinoma. J Comp Pathol. 2010;142:36-42 pubmed publisher
    ..These results suggest that VEGF may contribute to the high angiogenic phenotype of canine IMC and that this expression may underlie the tendency towards local and systemic metastasis of these tumours...
  59. Matsuoka Y, Hamaguchi T, Fukamachi K, Yoshida M, Watanabe G, Taya K, et al. Molecular analysis of rat mammary carcinogenesis: an approach from carcinogenesis research to cancer prevention. Med Mol Morphol. 2007;40:185-90 pubmed
    ..In this review, we summarize molecular aspects of mammary carcinogenesis in transgenic rats and the potential application of this model for studies of breast cancer prevention...
  60. Gordon R, Hunter K, La Merrill M, Sørensen P, Threadgill D, Pomp D. Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis. Mamm Genome. 2008;19:179-89 pubmed publisher
    ..These findings highlight the importance of accurately modeling not only the human cancer characteristics in mice but also the environmental exposures of human populations...
  61. Penzo C, Ross M, Muirhead R, Else R, Argyle D. Effect of recombinant feline interferon-omega alone and in combination with chemotherapeutic agents on putative tumour-initiating cells and daughter cells derived from canine and feline mammary tumours. Vet Comp Oncol. 2009;7:222-9 pubmed publisher
    ..The results suggest that rFeIFN-omega warrants further investigation as a therapeutic adjunct in feline and canine mammary tumours...
  62. Matsumura S, Wang B, Kawashima N, Braunstein S, Badura M, Cameron T, et al. Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol. 2008;181:3099-107 pubmed
    ..The ability of IR to convert tumors into "inflamed" peripheral tissues could be exploited to overcome obstacles at the effector phase of the antitumor immune response and improve the therapeutic efficacy of immunotherapy...
  63. Krol M, Pawłowski K, Skierski J, Turowski P, Majewska A, Polanska J, et al. Transcriptomic "portraits" of canine mammary cancer cell lines with various phenotypes. J Appl Genet. 2010;51:169-83 pubmed publisher
    ..Metastatic properties of mammary cancer cells seem to be associated with elevated expression of PGP (P glycoprotein), SEMA3B (semaphorin 3B), and STIM1 (stromal interaction molecule 1)...
  64. Vafaizadeh V, Klemmt P, Brendel C, Weber K, Doebele C, Britt K, et al. Mammary epithelial reconstitution with gene-modified stem cells assigns roles to Stat5 in luminal alveolar cell fate decisions, differentiation, involution, and mammary tumor formation. Stem Cells. 2010;28:928-38 pubmed publisher
    ..The tumors expressed activated Stat5 and Stat3 and contained a small fraction of CD44(+) cells, possibly indicative of cancer stem cells...
  65. Pawlowski K, Krol M, Majewska A, Badowska Kozakiewicz A, Mol J, Malicka E, et al. Comparison of cellular and tissue transcriptional profiles in canine mammary tumor. J Physiol Pharmacol. 2009;60 Suppl 1:85-94 pubmed
  66. Taneja P, Frazier D, Kendig R, Maglic D, Sugiyama T, Kai F, et al. MMTV mouse models and the diagnostic values of MMTV-like sequences in human breast cancer. Expert Rev Mol Diagn. 2009;9:423-40 pubmed publisher
    ..Thus, the detection of MMTV-like sequences may have diagnostic value to predict the clinical outcome of breast cancer patients...
  67. Torres C, Pino A, Sierralta W. A cyclized peptide derived from alpha fetoprotein inhibits the proliferation of ER-positive canine mammary cancer cells. Oncol Rep. 2009;21:1397-404 pubmed
    ..All canine mammary tumor cells in culture responded to treatments analogously to human mammary cancer cells. Our results support the proposal of cP as a new, potentially effective therapeutic agent for the management of mammary cancer...
  68. Jiang W, Zhu Z, Thompson H. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver. Cancer Res. 2008;68:5492-9 pubmed publisher
  69. Martinez Ruzafa I, Dominguez P, Dervisis N, Sarbu L, Newman R, Cadile C, et al. Tolerability of gemcitabine and carboplatin doublet therapy in cats with carcinomas. J Vet Intern Med. 2009;23:570-7 pubmed publisher
    ..This study was performed to determine the toxicity of gemcitabine-carboplatin doublet therapy in cats with carcinomas...
  70. Ikeda J, Morii E, Liu Y, Qiu Y, Nakamichi N, Jokoji R, et al. Prognostic significance of CD55 expression in breast cancer. Clin Cancer Res. 2008;14:4780-6 pubmed publisher
  71. Allington T, Galliher Beckley A, Schiemann W. Activated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors. FASEB J. 2009;23:4231-43 pubmed publisher
    ..Notably, our findings strongly caution against the use of pharmacological Abl antagonists in the treatment of developing and progressing mammary tumors...
  72. Gu Y, Zhang S, Wu Q, Xu S, Cui Y, Yang Z, et al. Differential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer. J Exp Clin Cancer Res. 2010;29:6 pubmed publisher
    ..In this study, we investigate differential gene expression, especially the expression of decorin, EGFR and cyclin D1, during mammary gland epithelial cell carcinogenesis in TA2 mice...
  73. Zhao Y, Li J, Xing Y, Wang J, Lu C, Xin X, et al. N-acetylglucosaminyltransferase V mediates cell migration and invasion of mouse mammary tumor cells 4TO7 via RhoA and Rac1 signaling pathway. Mol Cell Biochem. 2008;309:199-208 pubmed
    ..All these notions disclose for the first time that GnT-V and beta1, 6GlcNAc branching mediate the cell migration and invasion in Rac1-positive and RhoA-negative regulatory manners...
  74. Grizzle W, Xu X, Zhang S, Stockard C, Liu C, Yu S, et al. Age-related increase of tumor susceptibility is associated with myeloid-derived suppressor cell mediated suppression of T cell cytotoxicity in recombinant inbred BXD12 mice. Mech Ageing Dev. 2007;128:672-80 pubmed
    ..Thus, the accumulation of immunosuppresssing myeloid cells appears to contribute to the increase of tumor susceptibility as the age of mice increases...
  75. Klopfleisch R, Klose P, da Costa A, Brunnberg L, Gruber A. HEPACAM1 and 2 are differentially regulated in canine mammary adenomas and carcinomas and its lymph node metastases. BMC Vet Res. 2010;6:15 pubmed publisher
  76. Bachawal S, Wali V, Sylvester P. Combined gamma-tocotrienol and erlotinib/gefitinib treatment suppresses Stat and Akt signaling in murine mammary tumor cells. Anticancer Res. 2010;30:429-37 pubmed
    ..However, combination treatment of TKIs with gamma-tocotrienol targets multiple ErbB receptors and significantly inhibit +SA murine mammary tumor cell growth...
  77. Dias Pereira P, Lopes C, Matos A, Pinto D, Gartner F, Lopes C, et al. Estrogens metabolism associated with polymorphisms: influence of COMT G482a genotype on age at onset of canine mammary tumors. Vet Pathol. 2008;45:124-30 pubmed publisher
    ..Our results point to the combined effect of COMT genotype with other genetic and/or environmental risk factors as important key factors for mammary tumor etiopathogenesis...
  78. Pereira C, Luiz Navarro Marques F, Williams J, Wlademir De Martin B, Primo Bombonato P. 99mTc-labeled dextran for mammary lymphoscintigraphy in dogs. Vet Radiol Ultrasound. 2008;49:487-91 pubmed
    ..Lymphatic communications between lymph nodes were identified in 11 of 25 (44%) animals. 99mTc-dextran mammary lymphoscintigraphy was easy and rapid to perform and may provide valuable information for further studies...
  79. Wu D, Haruta A, Wei Q. GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion. J Biol Chem. 2010;285:28643-50 pubmed publisher
    ..Thus, our results suggest that GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion...
  80. Wang W, Zhou Y, Heng D, Miao C, Cao Y. Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and canstatin gene suppression therapy on breast tumor xenograft growth in mice. Breast Cancer Res Treat. 2008;110:283-95 pubmed
    ..Thus, the combination of TRAIL and canstatin appears to be a promising approach for the gene therapy of breast tumors...