calcifying odontogenic cyst

Summary

Summary: A mixed radiolucent-radiopaque lesion of the jaws with features of both a cyst and a solid neoplasm. It is characterized microscopically by an epithelial lining showing a palisaded layer of columnar basal cells, presence of ghost cell keratinization, dentinoid, and calcification. (Stedman, 25th ed)

Top Publications

  1. Murakami S, Koike Y, Matsuzaka K, Ohata H, Uchiyama T, Inoue T. A case of calcifying odontogenic cyst with numerous calcifications: immunohistochemical analysis. Bull Tokyo Dent Coll. 2003;44:61-6 pubmed
    The purpose of this study was to investigate a case of calcifying odontogenic cyst (COC) in which numerous calcifications were observed not only in the lining epithelium, but also in the cyst wall, using cytokeratins 13 (CK13), 19 (CK19),..
  2. Belmonte Caro R, Torres Lagares D, Mayorga Jimenez F, Garcia Perla Garcia A, Infante Cossio P, Gutierrez Perez J. Calcifying epithelial odontogenic tumor (Pindborg tumor). Med Oral. 2002;7:309-15 pubmed
    ..In spite of the existence of a recurrence rate of 14% after conservative treatment, we think that a quality treatment would require the practice of a block excision including healthy bony margins...
  3. Iida S, Fukuda Y, Ueda T, Aikawa T, Arizpe J, Okura M. Calcifying odontogenic cyst: radiologic findings in 11 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:356-62 pubmed
    ..The presence of impaction or displacement of teeth for COCs occurring in the posterior segments of the jaw, and absence of this finding for anteriorly placed lesions may be indicative of the timing of COC development. ..
  4. Eljack S, Reich R. AAOMP case challenge: A nonulcerated, slowly growing mass of the mandible. J Contemp Dent Pract. 2009;10:E097-100 pubmed
    ..A 38-year-old male presented with a slowly growing mass of the right mandible. The lesion displaced the mandibular canine and premolar teeth on the same side...
  5. Hassanein A, Glanz S, Kessler H, Eskin T, Liu C. beta-Catenin is expressed aberrantly in tumors expressing shadow cells. Pilomatricoma, craniopharyngioma, and calcifying odontogenic cyst. Am J Clin Pathol. 2003;120:732-6 pubmed
    ..beta-catenin immunohistochemical profile in tumors expressing shadow cells: pilomatricoma, 10 cases; calcifying odontogenic cyst, 6 cases; and craniopharyngioma, 9 cases...
  6. Takata T, Lu Y, Ogawa I, Zhao M, Zhou Z, Mock D, et al. Proliferative activity of calcifying odontogenic cysts as evaluated by proliferating cell nuclear antigen labeling index. Pathol Int. 1998;48:877-81 pubmed
    The calcifying odontogenic cyst (COC) presents with diverse histological features; thus, several subclassifications have been proposed...
  7. Oliveira J, da Silva C, Costa I, Loyola A. Calcifying odontogenic cyst in infancy: report of case associated with compound odontoma. ASDC J Dent Child. 1995;62:70-3 pubmed
    A case of calcifying odontogenic cyst associated with compound odontoma in an unerupted primary tooth in a three-year-old patient is reported...
  8. Yoon J, Kim H, Yook J, Cha I, Ellis G, Kim J. Hybrid odontogenic tumor of calcifying odontogenic cyst and ameloblastic fibroma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:80-4 pubmed
    ..We report an odontogenic tumor that was composed of calcifying odontogenic cyst and ameloblastic fibroma that occurred in the right posterior maxilla of a 22-year-old Korean woman...
  9. Iida S, Ueda T, Aikawa T, Kishino M, Okura M, Kogo M. Ameloblastomatous calcifying odontogenic cyst in the mandible. Dentomaxillofac Radiol. 2004;33:409-12 pubmed
    ..This feature was different from the general findings of COC and rather resembled that of ameloblastomas...

More Information

Publications79

  1. Fregnani E, Pires F, Quezada R, Shih I, Vargas P, de Almeida O. Calcifying odontogenic cyst: clinicopathological features and immunohistochemical profile of 10 cases. J Oral Pathol Med. 2003;32:163-70 pubmed
    b>Calcifying odontogenic cyst (COC) is an uncommon odontogenic lesion with few studies describing its immunohistochemical profile and proliferative activity reported in the literature.
  2. Gallana Alvarez S, Mayorga Jimenez F, Torres Gómez F, Avellá Vecino F, Salazar Fernandez C. Calcifying odontogenic cyst associated with complex odontoma: case report and review of the literature. Med Oral Patol Oral Cir Bucal. 2005;10:243-7 pubmed
    We report a calcifying odontogenic cyst associated with odontoma (COCaO) and an included permanent canine in the superior maxilla, in a 19 year-old-man...
  3. Lin C, Chen C, Lin L, Chen Y, Wright J, Kessler H, et al. Calcifying odontogenic cyst with ameloblastic fibroma: report of three cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:451-60 pubmed
    ..ameloblastic fibroma (AF), ameloblastic fibro-odontoma, and odontoma have been reported associated with calcifying odontogenic cyst (COC). There are only four cases of COC with AF cited in the English literature...
  4. Kusama K, Katayama Y, Oba K, Ishige T, Kebusa Y, Okazawa J, et al. Expression of hard alpha-keratins in pilomatrixoma, craniopharyngioma, and calcifying odontogenic cyst. Am J Clin Pathol. 2005;123:376-81 pubmed
    ..examined in tumors expressing those cells: pilomatrixoma, 14 cases; craniopharyngioma, 17 cases; and calcifying odontogenic cyst (COC), 14 cases...
  5. Bhat S, Shetty S, Babu S, Shetty P, Ka F. A rare variant of calcifying odontogenic cyst with ameloblastoma presentation. Stomatologija. 2015;17:131-4 pubmed
    b>Calcifying odontogenic cyst is a rare entity which was first described by Gorlin, and also accounts for 1% of the jaw cysts according to Shear...
  6. Mosqueda Taylor A, Carlos Bregni R, Ledesma Montes C, Fillipi R, de Almeida O, Vargas P. Calcifying epithelial odontogenic tumor-like areas are common findings in adenomatoid odontogenic tumors and not a specific entity. Oral Oncol. 2005;41:214-5 pubmed
  7. Fernandes A, Duarte E, Pimenta F, Souza L, Santos V, Mesquita R, et al. Odontogenic tumors: a study of 340 cases in a Brazilian population. J Oral Pathol Med. 2005;34:583-7 pubmed
    ..The aim of this study was to determinate the relative frequency of odontogenic tumors (OTs) in a Brazilian population and to compare this data with previous reports...
  8. Song Y, Zhang W, Peng B, Wang C, Wang Q, Bian Z. Germline mutations of the PTCH gene in families with odontogenic keratocysts and nevoid basal cell carcinoma syndrome. Tumour Biol. 2006;27:175-80 pubmed
    ..The results suggest that germline mutations on PTCH can cause isolated OKC, and that the PTCH gene responsible for NBCCS plays an important role in the formation of OKCs even when they are not syndrome-related. ..
  9. Mosqueda Taylor A, Ledesma Montes C, Caballero Sandoval S, Portilla Robertson J, Ruiz Godoy Rivera L, Meneses Garcia A. Odontogenic tumors in Mexico: a collaborative retrospective study of 349 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84:672-5 pubmed
    ..6%), ameloblastoma (23.7%), myxoma (17.7%), adenomatoid odontogenic tumor (7.1%), and calcifying odontogenic cyst (6.8%)...
  10. Mesquita R, Lotufo M, Sugaya N, de Araujo N, de Araujo V. Peripheral clear cell variant of calcifying epithelial odontogenic tumor: Report of a case and immunohistochemical investigation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:198-204 pubmed
    ..Laminin and type IV collagen were immunodetectable around the strands, cords, and nests of epithelial cells. This report represents the seventh case of peripheral calcifying epithelial odontogenic tumor, clear cell variant. ..
  11. Piattelli A, Fioroni M, Di Alberti L, Rubini C. Immunohistochemical analysis of a dentinogenic ghost cell tumour. Oral Oncol. 1998;34:502-7 pubmed
    ..Completely negative were the ghost cells, giant cells and dentinoid material. In this tumour the cells expressing Mib-1 and bcl-2 could be the cells that proliferate, and that could undergo malignant transformation. ..
  12. Pistóia G, Gerlach R, dos Santos J, Montebelo Filho A. Odontoma-producing intraosseous calcifying odontogenic cyst: case report. Braz Dent J. 2001;12:67-70 pubmed
    The present report describes a case of odontoma-producing intraosseous calcifying odontogenic cyst in a 36-year-old Black male in the right mandibular bicuspid region...
  13. Cicconetti A, Tallarico M, Bartoli A, Ripari A, Maggiani F. Calcifying epithelial odontogenic (Pindborg) tumor. A clinical case. Minerva Stomatol. 2004;53:379-87 pubmed
    ..The postoperative histological examination of the tumor revealed typical benign features. The differential diagnosis and work-up of the tumor treatment are discussed in relation with its histological typing and localization in the jaws. ..
  14. Perfetti G, Artese L, Scarano A, Tete S, Piattelli A. Zebra XXIV, part 2. J Endod. 2002;28:340-1 pubmed
  15. Estrela C, Decurcio D, Silva J, Mendonça E, Estrela C. Persistent apical periodontitis associated with a calcifying odontogenic cyst. Int Endod J. 2009;42:539-45 pubmed publisher
    To report a case of calcifying odontogenic cyst (COC) that was suggestive of apical periodontitis adjacent to the roots of the maxillary incisor teeth...
  16. Reyes D, Villanueva J, Espinosa S, Cornejo M. Odontogenic calcificant cystic tumor: a report of two clinical cases. Med Oral Patol Oral Cir Bucal. 2007;12:E126-9 pubmed
    ..The purpose of this article is to present a review of the literature related to these two cases of OCCT and its treatment, putting an emphasis on its aetiology, biological behaviour and treatment. ..
  17. Martin Duverneuil N, Roisin Chausson M, Behin A, Favre Dauvergne E, Chiras J. Combined benign odontogenic tumors: CT and MR findings and histomorphologic evaluation. AJNR Am J Neuroradiol. 2001;22:867-72 pubmed
    ..Calcifying epithelial odontogenic tumors and calcifying odontogenic cysts are rare, benign odontogenic tumors. We report two cases of an exceptional combination of these tumors with either an ameloblastic fibroodontoma or an odontoma. ..
  18. Speight P, Takata T. New tumour entities in the 4th edition of the World Health Organization Classification of Head and Neck tumours: odontogenic and maxillofacial bone tumours. Virchows Arch. 2018;472:331-339 pubmed publisher
    ..For this reason, this new edition restores the odontogenic keratocyst and calcifying odontogenic cyst to the classification of odontogenic cysts and rejects the previous terminology (keratocystic ..
  19. Gong Y, Wang L, Chen X, Wang H, Wang X. [Expression of nuclear factor-kappaB, Ki-67 and matrix metalloproteinase-9 in calcifying odontogenic cyst]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2006;41:627-30 pubmed
    ..the expression of nuclear factor-kappaB (NF-kappaB), Ki-67 and matrix metalloproteinase-9 (MMP-9) in calcifying odontogenic cyst (COC), in order to investigate the proliferation and invasion of COC...
  20. Sugiyama M, Miyauchi M, Suei Y. Lesion in the maxilla with a multicystic appearance. J Oral Maxillofac Surg. 2004;62:1264-8 pubmed
  21. Gupta B, Ponniah I. The pattern of odontogenic tumors in a government teaching hospital in the southern Indian state of Tamil Nadu. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:e32-9 pubmed publisher
    ..This hospital-based study was designed to provide demographic data on odontogenic tumors from the southern Indian population in the state of Tamil Nadu for comparison with pertinent series from other geographic regions...
  22. Kawano K, Ono K, Yada N, Takahashi Y, Kashima K, Yokoyama S, et al. Malignant calcifying epithelial odontogenic tumor of the mandible: report of a case with pulmonary metastasis showing remarkable response to platinum derivatives. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:76-81 pubmed
    ..This suggests that platinum derivatives could be a chemotherapeutic agent of choice against this rare tumor...
  23. Wang Y, Chang Y, Wang J, Liu B, Sun A, Chiang C. Characteristics of calcifying odontogenic cyst in Taiwanese. J Formos Med Assoc. 2003;102:715-21 pubmed
    b>Calcifying odontogenic cyst (COC) is a rare type of odontogenic cyst. This retrospective study analyzed the clinical, radiographic, and histopathologic features of COC in Taiwanese.
  24. Sivapathasundharam B, Rafiudeen S. Calcifying odontogenic cyst. Report of two cases. Indian J Dent Res. 2001;12:41-5 pubmed
    b>Calcifying odontogenic cyst(COC) is an uncommon developmental odontogenic cyst and was first described by Gorlin in 1962. It is considered as extremely rare and accounts for only 1% of the jaw cysts reported...
  25. Deboni M, Naclério Homem M, Pinto Junior D, Traina A, Cavalcanti M. Clinical, radiological and histological features of calcifying epithelial odontogenic tumor: case report. Braz Dent J. 2006;17:171-4 pubmed
    ..Computed tomography imaging, radiographic and pathological findings, surgical patterns, gross anatomy of the lesion and the performed treatment are discussed...
  26. Matsuzaka K, Inoue T, Nashimoto M, Takemoto K, Ishikawa H, Asaka M, et al. A case of an ameloblastic fibro-odontoma arising from a calcifying odontogenic cyst. Bull Tokyo Dent Coll. 2001;42:51-5 pubmed
    This case report describes an ameloblastic fibro-odontoma arising from a calcifying odontogenic cyst (COC) in the mandible of a twenty-three-year old male...
  27. Ungari C, Poladas G, Giovannetti F, Carnevale C, Iannetti G. Pindborg tumor in children. J Craniofac Surg. 2006;17:365-9 pubmed
    ..Recurrence of disease many years after surgical therapy has been reported that is why a clinical and instrumental long-term follow-up of the patient are suggested...
  28. Roh G, Jeon B, Park B, Kim D, Hah Y, Kim J, et al. Ghost cell odontogenic carcinoma of the mandible: a case report demonstrating expression of tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor. J Craniomaxillofac Surg. 2008;36:419-23 pubmed publisher
    Ghost cell odontogenic carcinoma is a rare neoplastic variant of calcifying odontogenic cyst, with aggressive growth characteristics. A painful swelling in the jaws with local paraesthesia is the most common symptom...
  29. Ide F, Obara K, Mishima K, Saito I. Ameloblastoma ex calcifying odontogenic cyst (dentinogenic ghost cell tumor). J Oral Pathol Med. 2005;34:511-2 pubmed
    b>Calcifying odontogenic cyst (COC) has shown to be of extensive diversity in its clinical and histopathological features, as well as in its biological behavior...
  30. Takata T, Zhao M, Uchida T, Wang T, Aoki T, Bartlett J, et al. Immunohistochemical detection and distribution of enamelysin (MMP-20) in human odontogenic tumors. J Dent Res. 2000;79:1608-13 pubmed
  31. Gurel K, Sanal S, Gurel S, Kalfaoglu M, Boran C. Two maxillary lesions containing bony/calcified shells. Dentomaxillofac Radiol. 2009;38:296-300 pubmed publisher
    ..Diagnoses of a residual radicular cyst in one case and a calcified mucocoele (which is very rare) in the other case were predicted with the help of radiological findings and were confirmed surgically and histopathologically...
  32. Konouchi H, Asaumi J, Yanagi Y, Hisatomi M, Kishi K. Adenomatoid odontogenic tumor: correlation of MRI with histopathological findings. Eur J Radiol. 2002;44:19-23 pubmed
    ..The MRI features corresponded to the macroscopic findings of the histopathological examination...
  33. Basile J, Klene C, Lin Y. Calcifying odontogenic cyst with odontogenic keratocyst: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:e40-5 pubmed publisher
    The calcifying odontogenic cyst (COC), first identified as a separate and distinct lesion by Gorlin et al...
  34. Makos C, Nikolaidou A. Calcifying epithelial odontogenic tumour or Pindborg's tumour: features and behaviour in relation to a case. Int Dent J. 2004;54:457-60 pubmed
  35. Hafian H, Mauprivez C, Furon V, Pluot M, Lefevre B. [Pindborg tumor: a poorly differentiated form without calcification]. Rev Stomatol Chir Maxillofac. 2004;105:227-30 pubmed
    ..Pindborg tumor is a rare benign epithelial calcified odontogenic tumor. Radiological diagnosis is generally suspected because of the presence of calcifications...
  36. Peron J, Hardy H. [Mixed odontogenic tumours]. Rev Stomatol Chir Maxillofac. 2009;110:217-20 pubmed publisher
    ..The diagnosis may be confirmed only by an anatomopathological examination, along with clinical and radiological observations...
  37. Batra M, Wadhwa N, Mishra K. Cytologic diagnosis in benign odontogenic tumor with abundant calcification: a case report. Acta Cytol. 2009;53:460-2 pubmed
    ..Calcifying cystic odontogenic tumor (CCOT) accounts for a mere 2-6.8% of odontogenic tumors. The cytologic features of this uncommon entity are not well characterized and may prove challenging in atypical smears, as in our case...
  38. Rapidis A, Stavrianos S, Andressakis D, Lagogiannis G, Bertin P. Calcifying epithelial odontogenic tumor (CEOT) of the mandible: clinical therapeutic conference. J Oral Maxillofac Surg. 2005;63:1337-47 pubmed
  39. Sun Z, Liu B, Zhao Y. Radiopacity in syndrome keratocystic odontogenic tumour. Dentomaxillofac Radiol. 2008;37:175-8 pubmed publisher
    ..The component of the calculus was analysed by Fourier transform infrared spectrum...
  40. Daniels J. Recurrent calcifying odontogenic cyst involving the maxillary sinus. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:660-4 pubmed
    The calcifying odontogenic cyst is an uncommon lesion that occurs in both jaws, however involvement of the maxillary sinus is rare...
  41. Jones A, Craig G, Franklin C. Range and demographics of odontogenic cysts diagnosed in a UK population over a 30-year period. J Oral Pathol Med. 2006;35:500-7 pubmed
    ..The aim of this study was to determine the range of all histologically diagnosed odontogenic cysts along with age range, sex distribution and site of presentation over a 30-year period...
  42. Kantarci M, Ertas U, Alper F, Sutbeyaz Y, Karasen R, Onbas O. Gorlin's syndrome with a thin corpus callosum and a third ventricular cyst. Neuroradiology. 2003;45:390-2 pubmed
    ..We present a case of this syndrome with special emphasis on its unusual neuroradiological findings and radiological management...
  43. Laco J. [What is your diagnosis? Answer: Calcifying cystic odontogenic tumor]. Cesk Patol. 2006;42:181, 199 pubmed
  44. Lombardi T, Kuffer R, Di Felice R, Samson J. Epithelial odontogenic ghost cell tumour of the mandibular gingiva. Oral Oncol. 1999;35:439-42 pubmed
    ..The epithelial odontogenic ghost cell tumour (EOGCT) is considered as a solid 'neoplastic' variant of the calcifying odontogenic cyst and is an uncommon lesion for which various names have been proposed over the years...
  45. Berger A, Allal A, Giannelli S, Zulian G. Reversal of refractory hypercalcemia using palliative radiotherapy in recurrent Pindborg's tumour. J Palliat Care. 2003;19:140-1 pubmed
  46. Poomsawat S, Punyasingh J. Calcifying epithelial odontogenic tumor: an immunohistochemical case study. J Mol Histol. 2007;38:103-9 pubmed
    ..These dendritic cells are likely to be Langerhans cells. Hence, immunohistochemistry is a useful method to study the variant of CEOT...
  47. Aithal D, Reddy B, Mahajan S, Boaz K, Kamboj M. Ameloblastomatous calcifying odontogenic cyst: a rare histologic variant. J Oral Pathol Med. 2003;32:376-8 pubmed
    b>Calcifying odontogenic cyst (COC) is an uncommon developmental odontogenic cyst first described by Gorlin in 1962. It is considered as extremely rare and accounts for only 1% of jaw cysts reported...
  48. Gopalakrishnan R, Simonton S, Rohrer M, Koutlas I. Cystic variant of calcifying epithelial odontogenic tumor. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102:773-7 pubmed
    ..Because follow-up has been for less than 1 year, a meaningful long-term prognosis cannot be determined at present. However, the patient has not reported any symptoms or signs of recurrence during the follow-up period...
  49. Li T, Yu S. [The nature of calcifying odontogenic cysts of the jaws]. Zhonghua Bing Li Xue Za Zhi. 2002;31:510-3 pubmed
    ..To clarify the clinicopathological and behavioral spectrum of the so-called calcifying odontogenic cysts (COC)...
  50. Mimura M, Tanaka N, Kimijima Y, Ichinose S, Sasaki K, Amagasa T. An ultrastructural study of calcifying odontogenic cyst, especially calcified material. Med Electron Microsc. 2002;35:109-16 pubmed
    The ultrastructural features of calcification in a case of calcifying odontogenic cyst (COC) were studied...
  51. Quinn M, Brace M, Bullock M, Hart R, Taylor S. Dentinogenic ghost cell tumor of the maxilla. Otolaryngol Head Neck Surg. 2008;139:604-5 pubmed publisher
  52. Knezevic G, Sokler K, Kobler P, Manojlovic S. Calcifying odontogenic cyst--Gorlin's cyst--report of two cases. Coll Antropol. 2004;28:357-62 pubmed
    ..In the first case the radiographic findings and clinical status did not indicate the presence of a calcifying odontogenic cyst. In the second case, differential diagnosis included COC...
  53. Ladeinde A, Ajayi O, Ogunlewe M, Adeyemo W, Arotiba G, Bamgbose B, et al. Odontogenic tumors: a review of 319 cases in a Nigerian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:191-5 pubmed
    ..This study sought to determine the relative frequency of odontogenic tumors in a Nigerian population and to compare these data with previous reports...
  54. Crivelini M, Felipini R, Coclete G, Soubhia A. Immunoexpression of keratins in the calcifying cystic odontogenic tumor epithelium. J Oral Pathol Med. 2009;38:393-6 pubmed publisher
  55. Adebayo E, Ajike S, Adekeye E. A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg. 2005;63:811-9 pubmed
    ..To analyze 318 odontogenic tumors seen at a tertiary oral care center in Kaduna, Nigeria for comparison with findings in previous Nigerian and world records...
  56. McIntosh J, Campbell J, Aguirre A, Reddy L, Elhadi H. Expansile mass of the maxilla. J Oral Maxillofac Surg. 2008;66:1253-8 pubmed publisher
  57. Moleri A, Moreira L, Carvalho J. Comparative morphology of 7 new cases of calcifying odontogenic cysts. J Oral Maxillofac Surg. 2002;60:689-96 pubmed
  58. Kamboj M, Juneja M. Ameloblastomatous Gorlin's cyst. J Oral Sci. 2007;49:319-23 pubmed
    The calcifying odontogenic cyst (COC), first described by Gorlin et al. in 1962, represents a heterogeneous group of lesions that exhibit a variety of clinicopathologic and behavioral features...
  59. Chindasombatjaroen J, Kakimoto N, Akiyama H, Kubo K, Murakami S, Furukawa S, et al. Computerized tomography observation of a calcifying cystic odontogenic tumor with an odontoma: case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:e52-7 pubmed
    ..The diagnosis was confirmed based on computerized tomography findings, which clearly depicted the internal structures obscured in conventional images...
  60. Poomsawat S, Punyasingh J, Vejchapipat P. Expression of basement membrane components in odontogenic tumors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:666-75 pubmed
    ..The objective was to characterize the expression of BMCs (laminins 1 and 5, collagen type IV, and fibronectin) in ameloblastomas, calcifying cystic odontogenic tumors (CCOTs), and adenomatoid odontogenic tumors (AOTs)...
  61. Baughman R, de la Rua H. Testing your diagnostic skills (#61). Case 1. Periodontal abscess, lateral periodontal cyst and odontogenic keratocyst. Todays FDA. 2002;14:29, 31 pubmed
  62. Gong Y, Wang L, Wang H, Li T, Chen X. The expression of NF-kappaB, Ki-67 and MMP-9 in CCOT, DGCT and GCOC. Oral Oncol. 2009;45:515-20 pubmed publisher
    ..GCOC show significantly higher proliferative activity than CCOT and DGCT. MMP-9 in stroma is associated with invasive ability of the CCOT, DGCT and GCOC...
  63. Lucchese A, Scivetti M, Pilolli G, Favia G. Analysis of ghost cells in calcifying cystic odontogenic tumors by confocal laser scanning microscopy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:391-4 pubmed
    ..In this study we have used the confocal microscope to analyze ghost cells in calcifying cystic odontogenic tumors...
  64. Ahn S, Kim S, Kim S, Lee S, Kim J, Yoon J. Beta-catenin gene alterations in a variety of so-called calcifying odontogenic cysts. APMIS. 2008;116:206-11 pubmed publisher
    ..These findings indicate that aberrations of the Wnt signaling pathway may perform a crucial role in the development and differentiation status of the odontogenic epithelium in COCs via the deregulation of cell proliferation...
  65. Moreira P, Guimarães M, Gomes C, Diniz M, Brito J, de Castro W, et al. Methylation frequencies of cell-cycle associated genes in epithelial odontogenic tumours. Arch Oral Biol. 2009;54:893-7 pubmed publisher
    ..The aim of this study was to investigate the methylation status of P16, P21, P27, P53 and RB1 genes in epithelial odontogenic tumours...
  66. Souza L, Souza A, Gomes C, Loyola A, Durighetto A, Gomez R, et al. Conservative treatment of calcifying odontogenic cyst: report of 3 cases. J Oral Maxillofac Surg. 2007;65:2353-6 pubmed
  67. Yun K, Lee J, Lee Y, Kim T, Park J. Dentinogenic ghost cell tumors. J Oral Maxillofac Surg. 2007;65:1816-9 pubmed
  68. Buchner A, Merrell P, Carpenter W. Relative frequency of peripheral odontogenic tumors: a study of 45 new cases and comparison with studies from the literature. J Oral Pathol Med. 2006;35:385-91 pubmed
  69. Siqueira A, Carvalho M, Monteiro A, Freitas V, Jaeger R, Pinheiro J. Matrix metalloproteinases, TIMPs and growth factors regulating ameloblastoma behaviour. Histopathology. 2010;57:128-37 pubmed publisher
    ..The aim was to study expression of MMPs, tissue inhibitor of metalloproteinases (TIMPs) and growth factors in ameloblastoma...
  70. Betts A, Camilleri G. A review of 47 cases of unerupted maxillary incisors. Int J Paediatr Dent. 1999;9:285-92 pubmed
    ..To study the prevalence of aetiological factors associated with unerupted maxillary incisors and to follow the outcome of treatment in a study of 47 cases...