bone cysts

Summary

Summary: Benign unilocular lytic areas in the proximal end of a long bone with well defined and narrow endosteal margins. The cysts contain fluid and the cyst walls may contain some giant cells. Bone cysts usually occur in males between the ages 3-15 years.

Top Publications

  1. Violas P, Salmeron F, Chapuis M, Sales de Gauzy J, Bracq H, Cahuzac J. Simple bone cysts of the proximal humerus complicated with growth arrest. Acta Orthop Belg. 2004;70:166-70 pubmed
  2. Arazi M, Senaran H, Memik R, Kapicioglu S. Minimally invasive treatment of simple bone cysts with percutaneous autogenous bone marrow injection. Orthopedics. 2005;28:108-12 pubmed
    Percutaneous autogeneic bone marrow injection is an effective method for managing simple bone cysts, and it might be considered before the application of more extensive procedures.
  3. Park I, Micic I, Jeon I. A study of 23 unicameral bone cysts of the calcaneus: open chip allogeneic bone graft versus percutaneous injection of bone powder with autogenous bone marrow. Foot Ankle Int. 2008;29:164-70 pubmed publisher
    ..The purpose of this study was to compare the results of open chip allogeneic bone graft versus percutaneous injection of demineralized bone powder with autogenous bone marrow in management of calcaneal cysts...
  4. Hirn M, de Silva U, Sidharthan S, Grimer R, Abudu A, Tillman R, et al. Bone defects following curettage do not necessarily need augmentation. Acta Orthop. 2009;80:4-8 pubmed publisher
    ..The natural pattern of bone healing in large bony defects following curettage alone as treatment of benign bone tumors around the knee is not well reported. We analyzed the outcome in 146 patients...
  5. Tanamas S, Wluka A, Pelletier J, Martel Pelletier J, Abram F, Wang Y, et al. The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study. Arthritis Res Ther. 2010;12:R58 pubmed publisher
    To examine the natural history of subchondral bone cysts and to determine whether knee cartilage loss and risk of joint replacement is higher in knees with cysts, compared with those with bone marrow lesions (BMLs) only or those with ..
  6. Crema M, Roemer F, Marra M, Guermazi A. MR imaging of intra- and periarticular soft tissues and subchondral bone in knee osteoarthritis. Radiol Clin North Am. 2009;47:687-701 pubmed publisher
    ..Cross-sectional and longitudinal evaluation has enabled us to understand their relevance in explaining pain and structural progression...
  7. Baig R, Eady J. Unicameral (simple) bone cysts. South Med J. 2006;99:966-76 pubmed
    Since their original description by Virchow, simple bone cysts have been studied repeatedly. Although these defects are not true neoplasms, simple bone cysts may create major structural defects of the humerus, femur, and os calcis...
  8. Tuzuner T. Penetrating type intraosseous ganglion cyst of the lunate bone. West Indian Med J. 2005;54:247-9 pubmed
    ..The patient was successfully treated by surgical intervention. Intraosseous ganglion cyst should be considered in the differential diagnosis of chronic dull wrist pain...
  9. Pedzisz P, Zgoda M, Kocon H, Benke G, Gorecki A. Treatment of solitary bone cysts with allogenic bone graft and platelet-rich plasma. A preliminary report. Acta Orthop Belg. 2010;76:374-9 pubmed
    The treatment of solitary bone cysts remains controversial. The high recurrence rate after operative treatment calls for the search of new effective treatment methods...

More Information

Publications63

  1. Dormans J, Sankar W, Moroz L, Erol B. Percutaneous intramedullary decompression, curettage, and grafting with medical-grade calcium sulfate pellets for unicameral bone cysts in children: a new minimally invasive technique. J Pediatr Orthop. 2005;25:804-11 pubmed
    Several treatment options exist for unicameral bone cysts (UBCs), including observation, steroid injection, bone marrow injection, and curettage and bone grafting...
  2. Docquier P, Delloye C. Autologous bone marrow injection in the management of simple bone cysts in children. Acta Orthop Belg. 2004;70:204-13 pubmed
    The majority of simple bone cysts (SBC's) is not symptomatic and remains undiagnosed or is discovered fortuitously. A number of simple bone cysts are only diagnosed after a pathological fracture which occurs as a presenting symptom...
  3. Yanagawa T, Watanabe H, Shinozaki T, Takagishi K. Curettage of benign bone tumors without grafts gives sufficient bone strength. Acta Orthop. 2009;80:9-13 pubmed publisher
    ..The defect that results after curettage of a bone tumor is usually filled in the same way. We report the outcome in patients with benign bone tumors that were treated with curettage but no filling...
  4. Hunt K, Bergeson A, Coffin C, Randall R. Percutaneous curettage and bone grafting for humeral simple bone cysts. Orthopedics. 2009;32:89 pubmed
    Traditional treatments for simple bone cysts are associated with significant surgical morbidity and high recurrence rates...
  5. Zehetgruber H, Bittner B, Gruber D, Krepler P, Trieb K, Kotz R, et al. Prevalence of aneurysmal and solitary bone cysts in young patients. Clin Orthop Relat Res. 2005;439:136-43 pubmed
    Aneurysmal and solitary bone cysts develop most commonly during skeletal growth...
  6. Kanellopoulos A, Yiannakopoulos C, Soucacos P. Percutaneous reaming of simple bone cysts in children followed by injection of demineralized bone matrix and autologous bone marrow. J Pediatr Orthop. 2005;25:671-5 pubmed
    The authors report the successful treatment of 19 patients (mean age 10 years) with active unicameral bone cysts using a combination of percutaneous reaming and injection of a mixture of demineralized bone matrix and autologous bone ..
  7. Saraph V, Zwick E, Maizen C, Schneider F, Linhart W. Treatment of unicameral calcaneal bone cysts in children: review of literature and results using a cannulated screw for continuous decompression of the cyst. J Pediatr Orthop. 2004;24:568-73 pubmed
    Nine unicameral bone cysts of the calcaneus in children were managed surgically using the technique of continuous decompression with titanium cannulated cancellous screws. The average age of the patients at surgery was 12.8 years...
  8. McErlain D, Milner J, Ivanov T, Jencikova Celerin L, Pollmann S, Holdsworth D. Subchondral cysts create increased intra-osseous stress in early knee OA: A finite element analysis using simulated lesions. Bone. 2011;48:639-46 pubmed publisher
    ..To investigate the role of intra-osseous lesions in advancing the pathogenesis of Osteoarthritis (OA) of the knee, using Finite Element Modeling (FEM) in conjunction with high-resolution imaging techniques...
  9. Hagmann S, Eichhorn F, Moradi B, Gotterbarm T, Dreher T, Lehner B, et al. Mid- and long-term clinical results of surgical therapy in unicameral bone cysts. BMC Musculoskelet Disord. 2011;12:281 pubmed publisher
    Unicameral (or simple) bone cysts (UBC) are benign tumours most often located in long bones of children and adolescents. Pathological fractures are common, and due to high recurrence rates, these lesions remain a challenge to treat...
  10. Kanellopoulos A, Mavrogenis A, Papagelopoulos P, Soucacos P. Elastic intramedullary nailing and DBM-bone marrow injection for the treatment of simple bone cysts. World J Surg Oncol. 2007;5:111 pubmed
    Simple or unicameral bone cysts are common benign fluid-filled lesions usually located at the long bones of children before skeletal maturity.
  11. Wang Y, Wluka A, Pelletier J, Martel Pelletier J, Abram F, Ding C, et al. Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees. Rheumatology (Oxford). 2010;49:997-1004 pubmed publisher
    ..The aim of the study was to examine the relationship between meniscal extrusion and knee cartilage and subchondral bone, and also changes in these structures over 2 years in a cohort with mild to moderate knee OA...
  12. Chouery E, Delague V, Bergougnoux A, Koussa S, Serre J, Megarbane A. Mutations in TREM2 lead to pure early-onset dementia without bone cysts. Hum Mutat. 2008;29:E194-204 pubmed publisher
    ..screen using 382 STR markers to localize and identify the gene implicated in early-onset dementia (EOD) without bone cysts in a Lebanese family with three affected subjects was conducted...
  13. Pogorelić Z, Furlan D, Biocic M, Mestrovic J, Juric I, Todoric D. Titanium intramedullary nailing for treatment of simple bone cysts of the long bones in children. Scott Med J. 2010;55:35-8 pubmed
    Simple or unicameral bone cysts are common benign fluid-filled lesions usually located in the long bones of children before skeletal maturity. Pathological fracture is common, and is often the presenting feature.
  14. Wright J, Yandow S, Donaldson S, Marley L. A randomized clinical trial comparing intralesional bone marrow and steroid injections for simple bone cysts. J Bone Joint Surg Am. 2008;90:722-30 pubmed publisher
    Simple bone cysts are common benign lesions in growing children that predispose them to fracture and are sometimes painful...
  15. Hammoud S, Weber K, McCarthy E. Unicameral bone cysts of the pelvis: a study of 16 cases. Iowa Orthop J. 2005;25:69-74 pubmed
    Unicameral bone cysts of the pelvis are extremely rare. This study summarizes the clinical, radiologic and pathologic features of 16 cases. Patients ranged in age from nine to 69...
  16. Klünemann H, Ridha B, Magy L, Wherrett J, Hemelsoet D, Keen R, et al. The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2. Neurology. 2005;64:1502-7 pubmed
    ..or Nasu-Hakola disease, is a presenile dementia associated with loss of myelin, basal ganglia calcification, and bone cysts. It is caused by recessively inherited mutations in two genes encoding subunits of a cell membrane-associated ..
  17. MacDonald K, Swanstrom M, McCarthy J, Nemeth B, Guliani T, Noonan K. Exaggerated inflammatory response after use of recombinant bone morphogenetic protein in recurrent unicameral bone cysts. J Pediatr Orthop. 2010;30:199-205 pubmed publisher
    Recurrent unicameral bone cysts (UBCs) can result in significant morbidity during a child's physical and emotional development...
  18. Dürr H, Martin H, Pellengahr C, Schlemmer M, Maier M, Jansson V. The cause of subchondral bone cysts in osteoarthrosis: a finite element analysis. Acta Orthop Scand. 2004;75:554-8 pubmed
    The etiology of subchondral bone cysts in arthrotic joints is unclear.
  19. MacInnes T, Thompson M, Lewis D. What is your diagnosis? Benign bone cysts. J Am Vet Med Assoc. 2005;227:1561-2 pubmed
  20. Di Bella C, Dozza B, Frisoni T, Cevolani L, Donati D. Injection of demineralized bone matrix with bone marrow concentrate improves healing in unicameral bone cyst. Clin Orthop Relat Res. 2010;468:3047-55 pubmed publisher
    Unicameral bone cysts are benign lesions that usually spontaneously regress with skeletal maturity; however, the high risk of pathologic fractures often justifies treatment that could reinforce a weakened bone cortex...
  21. Rapp M, Svoboda D, Wessel L, Kaiser M. Elastic Stable Intramedullary Nailing (ESIN), Orthoss® and Gravitational Platelet Separation--System (GPS®): an effective method of treatment for pathologic fractures of bone cysts in children. BMC Musculoskelet Disord. 2011;12:45 pubmed publisher
    The different treatment strategies for bone cysts in children are often associated with persistence and high recurrence rates of the lesions...
  22. Canavese F, Wright J, Cole W, Hopyan S. Unicameral bone cysts: comparison of percutaneous curettage, steroid, and autologous bone marrow injections. J Pediatr Orthop. 2011;31:50-5 pubmed publisher
    The purpose of this study was to compare the outcome of percutaneous curettage with intralesional injection of methylprednisolone and bone marrow for unicameral bone cysts (UBCs).
  23. Hass H, Krause H, Kroker S, Wagemann W, Meyer F. Bone formation using human demineralised bone matrix (Grafton) for the treatment of bone cysts in children. Eur J Pediatr Surg. 2007;17:45-9 pubmed
    b>Bone cysts, in particular solitary bone cysts, are the most frequent cause of pathological fractures in children. However, there is still a great variety of regimens used to treat these lesions...
  24. Donaldson S, Wright J. Recent developments in treatment for simple bone cysts. Curr Opin Pediatr. 2011;23:73-7 pubmed publisher
    The purpose of this paper is to review treatment strategies for simple bone cysts (SBCs).
  25. Crema M, Roemer F, Marra M, Niu J, Lynch J, Felson D, et al. Contrast-enhanced MRI of subchondral cysts in patients with or at risk for knee osteoarthritis: the MOST study. Eur J Radiol. 2010;75:e92-6 pubmed publisher
  26. Yilmaz G, Aksoy M, Alanay A, Yazici M, Alpaslan A. [Treatment of simple bone cysts with methylprednisolone acetate in children]. Acta Orthop Traumatol Turc. 2005;39:411-5 pubmed
    Steroid injections represent one of the simple treatment alternatives for simple bone cysts in pediatric age group. The aim of this study was to evaluate the results of steroid injections in the treatment of simple bone cysts.
  27. Guermazi A, Roemer F, Hayashi D. Imaging of osteoarthritis: update from a radiological perspective. Curr Opin Rheumatol. 2011;23:484-91 pubmed publisher
    ..To assist investigators in choosing the appropriate imaging technique for a particular goal of a study, this review describes, from a radiological point of view, key studies that were published between May 2010 and May 2011...
  28. Zamzam M, Abak A, Bakarman K, Al Jassir F, Khoshhal K, Zamzami M. Efficacy of aspiration and autogenous bone marrow injection in the treatment of simple bone cysts. Int Orthop. 2009;33:1353-8 pubmed publisher
    ..Our results suggested that autogenous bone marrow injection is a safe and effective treatment method for simple bone cysts, but sometimes repeated injections are necessary...
  29. Carrino J, Blum J, Parellada J, Schweitzer M, Morrison W. MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts. Osteoarthritis Cartilage. 2006;14:1081-5 pubmed
    ..To determine if a relationship exists between bone marrow edema-like signal and subchondral cysts on magnetic resonance imaging (MRI)...
  30. de Sanctis N, Andreacchio A. Elastic stable intramedullary nailing is the best treatment of unicameral bone cysts of the long bones in children?: Prospective long-term follow-up study. J Pediatr Orthop. 2006;26:520-5 pubmed
    ..Each lesion responded to treatment after the nailing. This method can solve in time the pathology, and we feel that, with skilled hands, this method is the best one for UBC treatment in the long bones of the children...
  31. Aspenberg P. Black holes in bone - irresistible attractors of foreign materials?. Acta Orthop. 2009;80:2-3 pubmed
  32. Gregory J, Arkader A, Bokhari A, Bothari A, Dormans J. Case report: unicameral bone cysts in a young patient with acquired generalized lipodystrophy. Clin Orthop Relat Res. 2010;468:1440-6 pubmed publisher
    We report the case of a 13-year-old boy with bilateral distal femoral unicameral bone cysts (UBCs) associated with acquired generalized lipodystrophy...
  33. Joeris A, Ondrus S, Planka L, Gal P, Slongo T. ChronOS inject in children with benign bone lesions--does it increase the healing rate?. Eur J Pediatr Surg. 2010;20:24-8 pubmed publisher
    ..The following study presents our results after treatment of these bone cysts with chronOS Inject.
  34. Thawrani D, Thai C, Welch R, Copley L, Johnston C. Successful treatment of unicameral bone cyst by single percutaneous injection of alpha-BSM. J Pediatr Orthop. 2009;29:511-7 pubmed publisher
    ..The purpose of this study was to evaluate clinical and radiographic outcomes of UBC treated by a single injection of alpha-BSM...
  35. Torres L, Dunlop D, Peterfy C, Guermazi A, Prasad P, Hayes K, et al. The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis. Osteoarthritis Cartilage. 2006;14:1033-40 pubmed
    ..Pain severity in knee OA is variable, ranging from barely perceptible to immobilizing. The knee lesions that contribute to pain severity have received little attention...
  36. Sung A, Anderson M, Zurakowski D, Hornicek F, Gebhardt M. Unicameral bone cyst: a retrospective study of three surgical treatments. Clin Orthop Relat Res. 2008;466:2519-26 pubmed publisher
    ..1979 and 2004, 167 patients younger than 20 years were treated surgically for humeral or femoral unicameral bone cysts with either injection of corticosteroids (steroids), curettage plus bone grafting (curettage), or a combination ..
  37. Vigler M, Weigl D, Schwarz M, Ben Itzhak I, Salai M, Bar on E. Subtrochanteric femoral fractures due to simple bone cysts in children. J Pediatr Orthop B. 2006;15:439-42 pubmed
    ..The cyst was fully obliterated in five patients and partially obliterated in two patients. One patient had a relative lengthening of 2 cm on the affected side. All patients were asymptomatic, fully active and had full range of motion...
  38. Tang X, Liu L, Peng M, Xiang B. Simple bone cysts in children treated with intracystic fibrin sealant injection. Chin Med J (Engl). 2006;119:523-5 pubmed
  39. Nishimura T, Tsujii M, Kusuzaki K, Hoki Y, Uchida A, Hirata H. Intra-osseous ganglion of the proximal humerus: a case report. J Orthop Surg (Hong Kong). 2007;15:102-5 pubmed
    ..The origins of intra-osseous ganglia vary and depend on their anatomical location. They can arise from within the bone or in the adjacent soft tissue, and can progress to a type-2 lesion in either an outside-in or inside-out fashion...
  40. McErlain D, Appleton C, Litchfield R, Pitelka V, Henry J, Bernier S, et al. Study of subchondral bone adaptations in a rodent surgical model of OA using in vivo micro-computed tomography. Osteoarthritis Cartilage. 2008;16:458-69 pubmed
    ..To non-invasively investigate the changes to epiphyseal bone occurring in a longitudinal pre-clinical model of osteoarthritis (OA) using in vivo micro-computed tomography (micro-CT)...
  41. Van den Dungen S, Marchesi S, Ezzedine R, Bindou D, Lorea P. Relationship between dorsal ganglion cysts of the wrist and intraosseous ganglion cysts of the carpal bones. Acta Orthop Belg. 2005;71:535-9 pubmed
    ..This high prevalence of intraosseous ganglia in association with soft tissue ganglia has to our knowledge never been reported previously. A common aetiology for these two types of ganglion cysts may explain this high association rate...
  42. Choate C, Arnold G. Elbow arthrodesis following a pathological fracture in a dog with bilateral humeral bone cysts. Vet Comp Orthop Traumatol. 2011;24:398-401 pubmed publisher
    ..A diagnosis of bilateral bone cysts of the humeral condyles with a pathologic fracture of the lateral aspect of the right humeral condyle was given ..
  43. Cho H, Oh J, Kim H, Kang H, Lee S. Unicameral bone cysts: a comparison of injection of steroid and grafting with autologous bone marrow. J Bone Joint Surg Br. 2007;89:222-6 pubmed
    ..the results of steroid injection with those of autologous bone marrow grafting for the treatment of unicameral bone cysts. Between 1990 and 2001, 30 patients were treated by steroid injection and 28 by grafting with autologous bone ..
  44. Roposch A, Saraph V, Linhart W. Treatment of femoral neck and trochanteric simple bone cysts. Arch Orthop Trauma Surg. 2004;124:437-42 pubmed
    Problems associated with common treatment modalities of bone cysts located in the proximal femur include a high blood loss, infection, lack of stability, donor-site morbidity, restriction to normal activity, and high recurrence rate.
  45. Raynauld J, Martel Pelletier J, Berthiaume M, Abram F, Choquette D, Haraoui B, et al. Correlation between bone lesion changes and cartilage volume loss in patients with osteoarthritis of the knee as assessed by quantitative magnetic resonance imaging over a 24-month period. Ann Rheum Dis. 2008;67:683-8 pubmed
    ..To evaluate in patients with knee osteoarthritis (OA) the size changes in bone oedema and cysts over 24 months, and to contrast these changes with cartilage volume loss using quantitative magnetic resonance imaging...
  46. Brecelj J, Suhodolcan L. Continuous decompression of unicameral bone cyst with cannulated screws: a comparative study. J Pediatr Orthop B. 2007;16:367-72 pubmed
    ..A total of 69 children with unicameral bone cysts were treated either by (i) open curettage and bone grafting, (ii) steroid injection or (iii) cannulated screw ..
  47. Williams H, Davies A, Allen G, Evans N, Mangham D. Imaging features of intraosseous ganglia: a report of 45 cases. Eur Radiol. 2004;14:1761-9 pubmed
    ..IGs, particularly when large, may be mistaken for a bone tumour. Correlation of the typical radiographic and MR imaging features will indicate the correct diagnosis and obviate the need for biopsy...
  48. Marker D, Seyler T, Jinnah R, Delanois R, Ulrich S, Mont M. Femoral neck fractures after metal-on-metal total hip resurfacing: a prospective cohort study. J Arthroplasty. 2007;22:66-71 pubmed
    ..These findings suggest the need for careful patient selection and surgical technique, especially for surgeons during the early learning curve for this technically difficult surgery...
  49. Pouders C, De Maeseneer M, Van Roy P, Gielen J, Goossens A, Shahabpour M. Prevalence and MRI-anatomic correlation of bone cysts in osteoarthritic knees. AJR Am J Roentgenol. 2008;190:17-21 pubmed
    ..objectives of this study were to determine the prevalence of cysts in the weight-bearing areas and interspinous bone cysts in tibial plateau specimens derived from knees with advanced osteoarthritis, to perform MRI-anatomic correlation ..
  50. Tey I, Mahadev A, Lim K, Lee E, Nathan S. Active unicameral bone cysts in the upper limb are at greater risk of fracture. J Orthop Surg (Hong Kong). 2009;17:157-60 pubmed
    ..To elucidate the natural history of unicameral bone cyst (UBC) and risk factors for pathological fracture...
  51. Mik G, Arkader A, Manteghi A, Dormans J. Results of a minimally invasive technique for treatment of unicameral bone cysts. Clin Orthop Relat Res. 2009;467:2949-54 pubmed publisher
    Unicameral bone cysts are benign bone lesions commonly seen in pediatric patients. Several treatment methods have been described with variable results and high recurrence rates...
  52. Knorr P, Schmittenbecher P, Dietz H. Elastic stable intramedullary nailing for the treatment of complicated juvenile bone cysts of the humerus. Eur J Pediatr Surg. 2003;13:44-9 pubmed
    Juvenile bone cysts usually are asymptomatic and may manifest as pathological fractures...
  53. Scranton P, McDermott J. Treatment of type V osteochondral lesions of the talus with ipsilateral knee osteochondral autografts. Foot Ankle Int. 2001;22:380-4 pubmed
    ..Preliminary results in ten consecutive patients show significant improvement in all patients with an average increase of 27 points in the AOFAS Hindfoot score...
  54. Chang C, Stanton R, Glutting J. Unicameral bone cysts treated by injection of bone marrow or methylprednisolone. J Bone Joint Surg Br. 2002;84:407-12 pubmed
    In 79 consecutive patients with unicameral bone cysts we compared the results of aspiration and injection of bone marrow with those of aspiration and injection of steroid. All were treated by the same protocol...