neoplasms

..Investigators have examined the pattern of multiple occurrences of four radiation-related neoplasms in a radiation-exposed cohort of 2795 patients receiving conventional radiation treatments for benign conditions ..

..glioblastoma (Grade IV). Glioblastomas differ from lower grades of astrocytic neoplasms; by being extremely aggressive, highly neovascularized and proliferative, as well as migratory/infiltrative...

..an important target for the investigation of the pathogenesis and ultimately the specific treatment of these neoplasms. The overall goal of this Program Project is to investigate how KSHV takes control of vascular endothelial cells ..

..the last 50 years or so researchers have used both inbred and outbred mice to study both spontaneous and induced neoplasms. Murine leukemia viruses (MuLVs) have been implicated in the spontaneous development of hematopoietic neoplasms ..

..B6C3F1-Trp53tm1Brd N12 (12th backcross generation) haploinsufficient mice develop hematopoietic stem cell (HSC) neoplasms after exposure to human carcinogens (including ionizing radiation, benzene, cyclophosphamide, melphalan, etc...

..A comprehensive analysis of 114,548 lymphoid neoplasms diagnosed during 1992-2001 classified according to the 2001 World Health Organization (WHO) lymphoma ..

..to improve the treatment of human metastatic CRC and may serve as a paradigm for the treatment of other solid neoplasms. To carry out this task, we propose a combination of pre-clinical studies in a conventional xenograft mouse ..

..to improve the treatment of human metastatic CRC and may serve as a paradigm for the treatment of other solid neoplasms. To carry out this task, we propose a combination of pre-clinical studies in a conventional xenograft mouse ..

..neuropathy, infertility, translocations of chromosomes 7 and 14, underdeveloped thymus, and increased risk of neoplasms leading to poor quality of life...

We have continued our studies on the pathogenesis of mouse B cell and plasma cell neoplasms that are induced by chromosomal T(12;15) translocations that result in the deregulated expression of the proto-oncogene Myc (c-myc)...

DESCRIPTION (provided by applicant): Tumors of the Ewing's sarcoma family (ESFT) are solid, highly malignant neoplasms of the bone and soft tissues that most often affect children and adolescents, being the second most common bone ..

DESCRIPTION (provided by applicant): Tumors of the Ewing's sarcoma family (ESFT) are solid, highly malignant neoplasms of the bone and soft tissues that most often affect children and adolescents, being the second most common bone ..

..pigmented nodular adrenocortical disease (PPNAD), pituitary adenoma, thyroid adenoma or carcinoma, testicular neoplasms, and ovarian tumors...

..described Ahi-1 (Abelson helper integration) gene altered by viral insertion in a variety of murine T and B cell neoplasms. Based on a prototype human cDNA clone, the human MRR1/Ahi-1 gene encodes a novel nuclear WD-protein with an ..

..behind the role of w-6 fat in the development and progression of mutant Kras-induced pancreatic intraepithelial neoplasms (PanINs) will illuminate dietary effects on pancreatic cancer development in the human population...

..to human health and has been implicated in both the apparent decline of male fertility and a rise in testicular neoplasms. Phthalate esters are widely used as plasticizers in consumer products and can leach into the environment, ..

..studies that have examined the relationship between dietary folate intake and the risk of developing colorectal neoplasms, have reported that higher folate intakes are associated with lower risk...

..is manifested by progressive weight loss, persistent diarrhea, anemia, opportunistic infections, and unusual neoplasms. Since the experimental infection of macaques with SIV results in similar clinical outcomes, animals used in ..

..behind the role of w-6 fat in the development and progression of mutant Kras-induced pancreatic intraepithelial neoplasms (PanINs) will illuminate dietary effects on pancreatic cancer development in the human population...

..elevation of glutathione levels are now recognized as effective strategies for reducing the risk of developing neoplasms caused by electrophilic carcinogens and reactive forms of oxygen...

..applicant): Effective cancer prevention depends on distinguishing between indolent and progressive pre-malignant neoplasms, so that the cost and risks of interventions can be focused on patients likely to progress to cancer, while ..

..have been demonstrated in families with FC, and loss of heterozygosity at the CYLD locus has been found in these neoplasms, suggesting that CYLD functions as a tumor suppressor...

..have been demonstrated in families with FC, and loss of heterozygosity at the CYLD locus has been found in these neoplasms, suggesting that CYLD functions as a tumor suppressor...

..As the mice age, they develop cystic malformations that resemble the intrapapillary mucinous neoplasms (IPMNs) seen in humans with PJS as well as sporadic cases...

..As the mice age, they develop cystic malformations that resemble the intrapapillary mucinous neoplasms (IPMNs) seen in humans with PJS as well as sporadic cases...

..Cisplatin is a potent chemotherapeutic agent widely used to treat patients with a variety of malignant neoplasms. Severe side effects including nephrotoxicity, neurotoxicity and ototoxicity limit doses that can be used...

..chondrodysplasias, overgrowth diseases like Beckwith Wiedernann syndrome, osteochondromas and other cartilage neoplasms, and some forms of osteoarthritis...

..chondrodysplasias, overgrowth diseases like Beckwith Wiedernann syndrome, osteochondromas and other cartilage neoplasms, and some forms of osteoarthritis...

..Myofibroblast derived growth factors are known to promote proliferation of epithelial neoplasms 5-7...

..Myofibroblast derived growth factors are known to promote proliferation of epithelial neoplasms 5-7...

..b>Neoplasms progress to malignancy through a process of clonal evolution...

..with beta carotene or placebo, there were no differences between the groups in the rates of malignant neoplasms, cancer mortality, cardiovascular mortality, or mortality from all causes...

..It accounts for about 36,000 cases of invasive cancer each year and is among the top five neoplasms affecting women...

..Thus, the incidence of secondary myeloid neoplasms is likely to increase as we cure other forms of cancer and 50% of secondary myeloid malignancies harbor ..

..Research Premise Although others and we have documented various genetic alterations in thyroid neoplasms, no specific alteration(s) can reliably distinguish benign from malignant lesions...

..Research Premise Although others and we have documented various genetic alterations in thyroid neoplasms, no specific alteration(s) can reliably distinguish benign from malignant lesions...

..Although overexpression of CYP1s has been linked to the development of several neoplasms an analogous knowledge base for OC is presently unavailable...

DESCRIPTION (provided by applicant): Cisplatin is a potent chemotherapeutic agent widely used to treat malignant neoplasms. Side effects, like ototoxicity compromise the quality of life of cancer survivors...

..a) analysis of the non-invasive breast cancers which developed in P1 subjects; (b) analysis of the endometrial neoplasms from this same study; and (c) genotyping of a random sample of the entire P1 cohort, to permit seeking evidence ..

..provided by applicant): Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, rapidly fatal neoplasms for which new therapeutic approaches are desperately needed...

..Thus, the incidence of secondary myeloid neoplasms is likely to increase as we cure other forms of cancer and 50% of secondary myeloid malignancies harbor ..

..either the production or function of these cells could result in suppressed host defenses against infection and neoplasms. A likely site at which such alterations could occur is in the bone marrow...

..the leading cause of death worldwide and rank third in the United States behind only heart disease and malignant neoplasms. In addition, recent bioterrorism events both here and abroad, have highlighted our need for researchers trained ..

..Nearly all individuals of fair skin bear multiple benign melanocytic neoplasms (nevi) expressing pro- oncogenic mutations in the MAPK pathway, usually in the BRAF or NRAS genes...

..Women with cancer or cervical intraepithelial neoplasms 2 or 3 (CIN 2 or 3) on biopsies will be classified as "high risk"...

..Nearly all individuals of fair skin bear multiple benign melanocytic neoplasms (nevi) expressing pro- oncogenic mutations in the MAPK pathway, usually in the BRAF or NRAS genes...

..Nearly all individuals of fair skin bear multiple benign melanocytic neoplasms (nevi) expressing pro- oncogenic mutations in the MAPK pathway, usually in the BRAF or NRAS genes...

..The childhood malignancy RMS, accounting for up to 10% of all pediatric neoplasms and for more than 50% of pediatric soft tissue sarcomas, is believed to arise from imbalances in skeletal muscle ..

..Pheochromocytomas are developmentally related to neuroblastomas, which are common adrenal medullary neoplasms, and pheochromocytoma cells can undergo neuronal differentiation...

..Our studies have linked Ndy1 to the induction of retrovirus-induced rodent hematopoietic neoplasms. Moreover, examination of its expression in existing databases has shown that Ndy1 is overexpressed in a variety ..

..FRCD) kit that is based not on cell morphology, but on the inherent differential genetics of renal cortical neoplasms, for commercial distribution by Cancer Genetics, Inc...

..is featured in neurological disorders, Williams-Beuren syndrome, skin ichthyosis and a variety of epithelial neoplasms. However, the significance of altered L3PSP activity on the initiation and course of these diseases is still not ..

..is featured in neurological disorders, Williams-Beuren syndrome, skin ichthyosis and a variety of epithelial neoplasms. However, the significance of altered L3PSP activity on the initiation and course of these diseases is still not ..

..recently identified gene that was initially discovered by virtue of its significant downregulation in colorectal neoplasms derived from patients with Hyperplastic Polyposis...

Medulloblastomas represent about 25 percent of all pediatric intracranial neoplasms. These highly malignant tumors arise from the cerebellum and affect mainly children between ages five and fifteen...

..Molecular and biochemical effects of small molecules cell cycle modulators in patients with advanced neoplasms Searching for available tissues (accessible by non-invasive means), we hypothesized that oral keratinocytes ..

..Because the surgical management for benign and malignant thyroid neoplasms differ, patients with suspicious FNAs may be treated in a less than ideal fashion surgically...

..Hippel-Lindau Syndrome (VHL) is an autosomal dominant heritable disorder in which multiple benign and malignant neoplasms and cysts of specific histopathologies develop in the kidney, adrenal gland, pancreas, brain, spinal cord, eye, ..

..Hippel-Lindau Syndrome (VHL) is an autosomal dominant heritable disorder in which multiple benign and malignant neoplasms and cysts of specific histopathologies develop in the kidney, adrenal gland, pancreas, brain, spinal cord, eye, ..

..Most colorectal cancers develop from sessile or pedunculated polypoid neoplasms. Early removal of such neoplasms has been observed to reduce the occurrence of colorectal carcinoma...

..mechanisms might be especially important in parathyroid tumors, possibly explaining why these cyclin D1-driven neoplasms are almost always benign in marked contrast with the malignant features of other cyclin D1-induced tumors, and ..

..WS patients also experience an increased risk of rare non-epithelial cancers, especially mesenchymal neoplasms such as sarcomas...

..Numerous studies have indicated that I3C also has a strong hepatoprotective activity against various carcinogens. Initial clinical trials in women have shown that I3C is a promising agent against breast and cervical cancers...

..Thus, this review also summarises the demonstrated antitumour actions of cannabinoids and indicates possible avenues for the future development of cannabinoids as antitumour agents...

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..This review provides a summary of the rationale for using proteasome inhibitors and an update on available and ongoing clinical studies involving human malignancies...

..Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting...

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..Taken together, these results suggest that SJ-8002 may be a candidate for strong anti-cancer agent with the ability to inhibit the angiogenesis of endothelial cells and to induce the apoptosis of tumor cells...

..Treatment with enzyme reduced serum VEGF levels of the tumor induced animals. In vitro VEGF production by EAC cells was reduced in a concentration dependent manner in presence of glutamine analogue...

..Their potent activity against osteosarcoma xenografts suggests that MDM2 antagonists may have clinical utility in the treatment of tumors with wild-type p53...

..These discoveries indicate that LPAAT-beta represents a potential novel cancer therapy target...

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..Here, we review PPAR gamma-induced antineoplastic signalling pathways, and summarise the antineoplastic effects of PPAR gamma agonists in different cancer cell lines, animal models, and clinical trials...

..An update on the efforts to develop novel Stat3 inhibitors for therapeutic application will also be provided...

..This chapter presents an overview of the drug resistance mechanisms...

..Only time will tell whether the search for the Holy Grail for treatment of cancer will end with TRAIL?..

..PS-341 represent the first of this promising class of agents that could have application in cancer therapy and it is the only that has progressed to clinical trials...

..Although still in its infancy, encouraging results have been reported using antisense oligodeoxynucleotide-based methods, as well as other approaches to interfere with MYC expression both in vitro and in vivo...

..This new concept may constitute a new approach for cancer therapy, which we tentatively designated as "Retro-differentiational Apoptosis Cancer Therapy", (R-ACT)...

..This observation will facilitate the design of specific inhibitors for Akt, a core intracellular survival factor underlying various human neoplastic diseases...

..This review will highlight promising rationally designed, target-based agents in clinical development, as well as the unique challenges involved in their successful development...

..Potent blockade of VEGF may provide a new therapeutic option for patients with bulky, metastatic cancers...

..These findings indicate new steps in the mechanism underlying ER-dependent anti-proliferative effects of Nar suggesting new potential chemopreventive actions of flavonoids on cancer growth...

..This article reviews the possibilities and challenges for targeted drug delivery in cancer therapy...

..In conclusion, CLA may be regarded as a component of the diet that exerts antineoplastic activity and its effect may be antiproliferative or pro-apoptotic...

..YC-1 has the potential to become the first antiangiogenic anticancer agent to target HIF-1 alpha...

..Results of current early-phase studies of non-small-cell lung, esophageal, cervical, and brain cancers will determine whether therapies that combine COX-2 inhibitors and radiation will enter randomized clinical trials...

..In summary, all chemotherapeutic agents were more active against endothelial cells in comparison to tumor cells. The hypothesis of an antiangiogenic active metronomic therapy could be confirmed in vivo by the use of adriamycin in RENCA...

..Further study of the effect of PEG-ZnPP plus conventional anticancer drugs that generate ROS, such as cisplatin, camptothecin, doxorubicin, mitomycin C and etoposide, is warranted...

..We venture to suggest that the clarification of the role of adenosine and its receptors in cancer development may hold great promise for the treatment of chemotherapy in patients affected by malignancies...

..Therefore, based on isotype specificity and antitumor activity, SK-7041 and SK-7068 HDAC inhibitors are expected to be promising anticancer therapeutic agents and need additional clinical development...

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..Our results identify MX-116407 as the lead candidate and strongly support its continued development as a novel anticancer agent for human use...

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..Alternative methods for Annexin A5 labeling and imaging may improve the detection of drug-induced apoptosis to monitor chemosensitivity...

..Furthermore, because the effective doses of both compounds are within clinically achievable range, this report will lead to immediate benefit for the development of a new cancer therapy...

..We will overview inhibitors of HIF-1alpha and will discuss their potential use for cancer therapy...

..v. doses of 50 mg/kg in nude mice. These findings indicate BPR0L075 is a promising anticancer compound with antimitotic activity that has potential for management of various malignancies, particularly for patients with drug resistance...

..We conclude that CPEC enhances the incorporation of dFdCTP into DNA and thus increases the cytotoxicity of gemcitabine in lymphocytic and myeloid leukemic cell-lines...

..Particularly important are combinations of platinum drug treatments with other drugs, radiation and the emerging gene therapy regimens...

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..Finally, we discuss the therapeutic implications of targeting angiogenesis and VEGF receptors, particularly in cancer therapy...

..Prospective clinical studies are currently investigating the efficacy of TRD on local and metastatic tumor growth in different malignancies...

..These results suggest that the binary targeting properties of SMA41 are associated with a binary cascade of events in the cells that seem to culminate into significant growth inhibition in vitro and in vivo...

..Furthermore, anthocyanins from O. sativa L. indica were evidenced by their inhibition on the growth of Lewis lung carcinoma cells in vivo...

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..Taken together, our findings indicate that ADCC represents an important effector mechanism of this Ab, which is effective at relatively low dose...

..Several epothilones are undergoing clinical evaluation and are promising candidates for advanced cancer therapy...

..The identification of these pathways not only allows a reinterpretation of NF-kappaB function in normal cells and during tumorigenesis but could also have implications for both traditional and NF-kappaB based cancer therapy...

..In vivo, 19D12 inhibits the tumor growth of a very aggressive human ovarian tumor xenograft model A2780. These data support the development of this anti-IGF-IR monoclonal antibody as a promising anticancer agent...

..These findings have implications for the design of T cell-based cancer immunotherapy...

..In this review we address the role of apoptosis signaling in tumorigenesis and drug resistance of tumor cells and discuss therapeutic approaches interfering with apoptosis pathways...

..B-17-SCID beige mice treated with SinRep/LacZ. CONCLUSION: Sindbis viral vectors efficiently targeted tumors in vivo, were apparently delivered through the circulation, and were more effective in the presence of NK cells...

..This signaling may influence cell survival, growth, and differentiation. Recent insight into the biology of pump regulation by CS is reviewed...

..These results suggest that JAK/STAT inhibitors deserve further investigation for use with IL-12 therapy in treating human cancers with elevated JAK/STAT activity...

..Here, the results of the clinical trials conducted so far will be reviewed, followed by a description of new approaches under development at present...

..Optimized decitabine doses and combinations with other epigenetic therapies that can be used at minimally toxic doses provide potentially safer therapeutic options and introduce novel combination therapies...

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