Summary: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.

Top Publications

  1. Jiao W, Vembu S, Deshwar A, Stein L, Morris Q. Inferring clonal evolution of tumors from single nucleotide somatic mutations. BMC Bioinformatics. 2014;15:35 pubmed publisher
    ..But automated methods to do this reconstruction are not available and the conditions under which reconstruction is possible have not been described...
  2. Hershman D, Lacchetti C, Dworkin R, Lavoie Smith E, Bleeker J, Cavaletti G, et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2014;32:1941-67 pubmed publisher
    ..To provide evidence-based guidance on the optimum prevention and treatment approaches in the management of chemotherapy-induced peripheral neuropathies (CIPN) in adult cancer survivors...
  3. Feldman D, Krishnan A, Swami S, Giovannucci E, Feldman B. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014;14:342-57 pubmed publisher
  4. Ward E, DeSantis C, Robbins A, Kohler B, Jemal A. Childhood and adolescent cancer statistics, 2014. CA Cancer J Clin. 2014;64:83-103 pubmed publisher
    ..In addition to cancer statistics, this article will provide an overview of risk factors, symptoms, treatment, and long-term and late effects for common pediatric cancers...
  5. Quail D, Joyce J. Microenvironmental regulation of tumor progression and metastasis. Nat Med. 2013;19:1423-37 pubmed publisher
    ..Here we discuss the paradoxical roles of the TME during specific stages of cancer progression and metastasis, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects. ..
  6. Roth A, Khattra J, Yap D, Wan A, Laks E, Biele J, et al. PyClone: statistical inference of clonal population structure in cancer. Nat Methods. 2014;11:396-8 pubmed publisher
    ..Single-cell sequencing validation demonstrates PyClone's accuracy. ..
  7. Keeble S, Abel G, Saunders C, McPhail S, Walter F, Neal R, et al. Variation in promptness of presentation among 10,297 patients subsequently diagnosed with one of 18 cancers: evidence from a National Audit of Cancer Diagnosis in Primary Care. Int J Cancer. 2014;135:1220-8 pubmed publisher
    ..These findings can help to prioritise public awareness initiatives and research focusing on symptoms of cancers associated with greater risk of non-prompt presentation, such as oro-pharyngeal and oesophageal cancer. ..
  8. Chaudhary B, Khaled Y, Ammori B, Elkord E. Neuropilin 1: function and therapeutic potential in cancer. Cancer Immunol Immunother. 2014;63:81-99 pubmed publisher
    ..This paper reviews current knowledge on the role and function of NRP1 in Tregs and pDCs, both in physiological and cancer settings, as well as its potential as a therapeutic target in cancer. ..
  9. Nangalia J, Massie C, Baxter E, Nice F, Gundem G, Wedge D, et al. Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2. N Engl J Med. 2013;369:2391-2405 pubmed publisher
    Somatic mutations in the Janus kinase 2 gene (JAK2) occur in many myeloproliferative neoplasms, but the molecular pathogenesis of myeloproliferative neoplasms with nonmutated JAK2 is obscure, and the diagnosis of these neoplasms remains ..

More Information


  1. Reedy J, Krebs Smith S, Miller P, Liese A, Kahle L, Park Y, et al. Higher diet quality is associated with decreased risk of all-cause, cardiovascular disease, and cancer mortality among older adults. J Nutr. 2014;144:881-9 pubmed publisher
  2. Borras J, Albreht T, Audisio R, Briers E, Casali P, Esperou H, et al. Policy statement on multidisciplinary cancer care. Eur J Cancer. 2014;50:475-80 pubmed publisher
    ..To that effect, a working group conference was held in January 2013 within the EPAAC Work Package 7 (on Healthcare) framework...
  3. Ciceri P, Müller S, O Mahony A, Fedorov O, Filippakopoulos P, Hunt J, et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol. 2014;10:305-12 pubmed publisher
    ..Furthermore, structure-activity relationships and co-crystal structures identify design features that enable a general platform for the rational design of dual kinase-bromodomain inhibitors. ..
  4. Zimmermann C, Swami N, Krzyzanowska M, Hannon B, Leighl N, Oza A, et al. Early palliative care for patients with advanced cancer: a cluster-randomised controlled trial. Lancet. 2014;383:1721-30 pubmed publisher
    ..Patients with advanced cancer have reduced quality of life, which tends to worsen towards the end of life. We assessed the effect of early palliative care in patients with advanced cancer on several aspects of quality of life...
  5. Khoo K, Hoe K, Verma C, Lane D. Drugging the p53 pathway: understanding the route to clinical efficacy. Nat Rev Drug Discov. 2014;13:217-36 pubmed publisher
    ..The challenge of targeting protein-protein interactions and a fragile mutant transcription factor has stimulated many exciting new approaches to drug discovery. ..
  6. Curti B, Kovacsovics Bankowski M, Morris N, Walker E, Chisholm L, Floyd K, et al. OX40 is a potent immune-stimulating target in late-stage cancer patients. Cancer Res. 2013;73:7189-7198 pubmed publisher
  7. He W, Calore F, Londhe P, Canella A, Guttridge D, Croce C. Microvesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7. Proc Natl Acad Sci U S A. 2014;111:4525-9 pubmed publisher
    ..Together, these results describe a unique pathway by which tumor cells promote muscle loss, which might provide a great insight into elucidating the causes and treatment options of cancer cachexia. ..
  8. Muller P, Vousden K. Mutant p53 in cancer: new functions and therapeutic opportunities. Cancer Cell. 2014;25:304-17 pubmed publisher
    ..Understanding the functions of mutant p53 will help in the development of new therapeutic approaches that may be useful in a broad range of cancer types. ..
  9. Templeton A, McNamara M, Seruga B, Vera Badillo F, Aneja P, Ocana A, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst. 2014;106:dju124 pubmed publisher
    ..Here we quantify the prognostic impact of this biomarker and assess its consistency in solid tumors...
  10. Czabotar P, Lessene G, Strasser A, Adams J. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat Rev Mol Cell Biol. 2014;15:49-63 pubmed publisher
  11. Heusschen R, Schulkens I, van Beijnum J, Griffioen A, Thijssen V. Endothelial LGALS9 splice variant expression in endothelial cell biology and angiogenesis. Biochim Biophys Acta. 2014;1842:284-92 pubmed publisher
    ..The function of the dominant splice variant, i.e. galectin-9?5, in endothelial cell biology depends on the concentration and environmental context in which it is presented to the cells. ..
  12. Singh H, Huls H, Kebriaei P, Cooper L. A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19. Immunol Rev. 2014;257:181-90 pubmed publisher
  13. De Angelis R, Sant M, Coleman M, Francisci S, Baili P, Pierannunzio D, et al. Cancer survival in Europe 1999-2007 by country and age: results of EUROCARE--5-a population-based study. Lancet Oncol. 2014;15:23-34 pubmed publisher
    ..Major changes in cancer diagnosis, treatment, and rehabilitation occurred in the early 2000s. EUROCARE-5 assesses their effect on cancer survival in 29 European countries...
  14. Ramiro S, Gaujoux Viala C, Nam J, Smolen J, Buch M, Gossec L, et al. Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis. Ann Rheum Dis. 2014;73:529-35 pubmed publisher
  15. Diaz L, Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol. 2014;32:579-86 pubmed publisher
  16. Lawrence M, Stojanov P, Mermel C, Robinson J, Garraway L, Golub T, et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature. 2014;505:495-501 pubmed publisher
    ..We estimate that near-saturation may be achieved with 600-5,000 samples per tumour type, depending on background mutation frequency. The results may help to guide the next stage of cancer genomics. ..
  17. Holmström K, Finkel T. Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol. 2014;15:411-21 pubmed publisher
  18. Davoli T, Xu A, Mengwasser K, Sack L, YOON J, Park P, et al. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013;155:948-62 pubmed publisher
    ..We propose that the cancer genome is shaped through a process of cumulative haploinsufficiency and triplosensitivity...
  19. Lee J, Ledermann J, Kohn E. PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol. 2014;25:32-40 pubmed publisher
  20. Patnaik A, LoRusso P, Messersmith W, Papadopoulos K, Gore L, Beeram M, et al. A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2014;73:951-60 pubmed publisher
    ..The safety of combining MNRP1685A with bevacizumab, with or without paclitaxel, was examined...
  21. Gilmartin A, Faitg T, Richter M, Groy A, Seefeld M, Darcy M, et al. Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction. Nat Chem Biol. 2014;10:181-7 pubmed publisher
    ..To our knowledge, GSK2830371 is the first orally active, allosteric inhibitor of Wip1 phosphatase. ..
  22. Nagaraju G, Dontula R, El Rayes B, Lakka S. Molecular mechanisms underlying the divergent roles of SPARC in human carcinogenesis. Carcinogenesis. 2014;35:967-73 pubmed publisher
    ..This review mainly focuses on recent advances in understanding the contradictory nature of SPARC in relation to ECM assembly, cancer cell proliferation, adhesion, migration, apoptosis and tumor growth. ..
  23. Chan K, Jiang P, Chan C, Sun K, Wong J, Hui E, et al. Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proc Natl Acad Sci U S A. 2013;110:18761-8 pubmed publisher
    ..These developments have thus expanded the applications of plasma DNA analysis for cancer detection and monitoring. ..
  24. Quaife S, Forbes L, Ramirez A, Brain K, Donnelly C, Simon A, et al. Recognition of cancer warning signs and anticipated delay in help-seeking in a population sample of adults in the UK. Br J Cancer. 2014;110:12-8 pubmed publisher
    ..We therefore investigated associations between recognition of warning signs for breast, colorectal and lung cancer and anticipated time to help-seeking for symptoms of each cancer...
  25. Newman A, Bratman S, To J, Wynne J, Eclov N, Modlin L, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20:548-54 pubmed publisher
    ..Finally, we evaluated biopsy-free tumor screening and genotyping with CAPP-Seq. We envision that CAPP-Seq could be routinely applied clinically to detect and monitor diverse malignancies, thus facilitating personalized cancer therapy. ..
  26. de Beer J, Liebenberg L. Does cancer risk increase with HbA1c, independent of diabetes?. Br J Cancer. 2014;110:2361-8 pubmed publisher
    ..Hyperglycaemia, hyperinsulinaemia, inflammation and altered hormonal concentrations are common characteristics between the two diseases and can all be linked to hyperglycaemia...
  27. Kaplan R, Maughan T, Crook A, Fisher D, Wilson R, Brown L, et al. Evaluating many treatments and biomarkers in oncology: a new design. J Clin Oncol. 2013;31:4562-8 pubmed publisher
    ..Using this approach allows questions regarding efficacy and safety of multiple novel therapies to be answered in a relatively quick and efficient manner, while also allowing for the assessment of biomarkers to help target treatment. ..
  28. Chiyomaru T, Fukuhara S, Saini S, Majid S, Deng G, Shahryari V, et al. Long non-coding RNA HOTAIR is targeted and regulated by miR-141 in human cancer cells. J Biol Chem. 2014;289:12550-65 pubmed publisher
    ..These results demonstrate that HOTAIR is suppressed by miR-141 in an Ago2-dependent manner. ..
  29. Gorrini C, Harris I, Mak T. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013;12:931-47 pubmed publisher
  30. Wong C, Martincorena I, Rust A, Rashid M, Alifrangis C, Alexandrov L, et al. Inactivating CUX1 mutations promote tumorigenesis. Nat Genet. 2014;46:33-8 pubmed publisher
    ..Thus, our complementary approaches identify CUX1 as a pan-driver of tumorigenesis and uncover a potential strategy for treating CUX1-mutant tumors. ..
  31. Muñoz Espín D, Serrano M. Cellular senescence: from physiology to pathology. Nat Rev Mol Cell Biol. 2014;15:482-96 pubmed publisher
    ..Conversely, antisenescent therapies may help to eliminate accumulated senescent cells and to recover tissue function. ..
  32. Gkegkes I, Iavazzo C. Advantages by using the intradermal microbubbles for sentinel lymph node detection in penile cancer. Hell J Nucl Med. 2016;19:289 pubmed publisher
    Dear Editor, Penile cancer has a relatively low incidence of 0.6% among all types of neoplasms. These incidents can reach up to 10% in the developing countries...
  33. Wang C, Ma Y, Zhao X, Sun P, Zhang Y, Huang M, et al. Glomus tumors of the trachea: 2 case reports and a review of the literature. J Thorac Dis. 2017;9:E815-E826 pubmed publisher
    Glomus tumors (GTs) of the trachea are very rare neoplasms that usually arise from the distal portion of the respiratory tree. The origin of these tumors is modified smooth muscle cells of glomus bodies...
  34. Steiner E, Kazianka L, Breuer R, Hacker M, Wadsak W, Mitterhauser M, et al. **-Postprandial pancreatic [11C]methionine uptake after pancreaticoduodenectomy mirrors basal beta cell function and insulin release. Eur J Nucl Med Mol Imaging. 2017;44:509-516 pubmed publisher
    ..shown to influence glycemic control in subjects after pancreaticoduodenectomy (PD, the surgical treatment of neoplasms of the pancreas head), we looked for imaginable relationships between gastric emptying, pre- and postprandial ..
  35. Diamond E, Subbiah V, Lockhart A, Blay J, Puzanov I, Chau I, et al. Vemurafenib for BRAF V600-Mutant Erdheim-Chester Disease and Langerhans Cell Histiocytosis: Analysis of Data From the Histology-Independent, Phase 2, Open-label VE-BASKET Study. JAMA Oncol. 2017;: pubmed publisher
    The histiocytic neoplasms Erdheim-Chester disease (ECD) and Langerhans cell histiocytosis (LCH) are highly enriched for BRAF V600 mutations and have been previously shown to be responsive to treatment with vemurafenib, an inhibitor of ..
  36. Yang W, Li C, Li L, Sheng S, Qi S, Pan J. [Postoperative infection bacteria and drug resistance in patients with oral and maxillofacial tumors]. Shanghai Kou Qiang Yi Xue. 2015;24:584-8 pubmed
    To evaluate postoperative infection patterns of patients suffering from oral and maxillofacial neoplasms. The risk factors giving rise to postoperative infections were analyzed...
  37. Bruchhage K, Wollenberg B, Schröder U. [Submental artery island flaps for reconstruction in the head and neck region]. HNO. 2015;63:747-51 pubmed publisher
    Reconstruction of defects after extirpation of head and neck neoplasms is a highly challenging and complex surgical undertaking...
  38. Ampie L, Choy W, Didomenico J, Lamano J, Williams C, Kesavabhotla K, et al. Clinical attributes and surgical outcomes of angiocentric gliomas. J Clin Neurosci. 2016;28:117-22 pubmed publisher
    Angiocentric gliomas (AG) are exceedingly rare low-grade neoplasms which often present in the form of intractable epilepsy within younger patients...
  39. Hara K, Saito T, Hayashi T, Yimit A, Takahashi M, Mitani K, et al. A mutation spectrum that includes GNAS, KRAS and TP53 may be shared by mucinous neoplasms of the appendix. Pathol Res Pract. 2015;211:657-64 pubmed publisher
    Appendiceal mucinous tumors (AMTs) are classified as low-grade appendiceal mucinous neoplasms (LAMNs) or mucinous adenocarcinomas (MACs), although their carcinogenesis is not well understood...
  40. Weil M. Conformal radiotherapy for brain tumors. Hematol Oncol Clin North Am. 2001;15:1007-15 pubmed
    ..Further studies evaluating the use of three-dimensional conformal radiotherapy in patients with nervous system neoplasms should focus on determining the effects on quality of life for the patient and survival compared with more ..
  41. Chisholm K, Ohgami R, Tan B, Hasserjian R, Weinberg O. Primary lymphoma of bone in the pediatric and young adult population. Hum Pathol. 2017;60:1-10 pubmed publisher
    Primary lymphoma of bone (PLB) accounts for 3% to 7% of primary neoplasms of bone and must be distinguished from more common bone tumors in the pediatric population such as osteosarcoma, Ewing sarcoma, and other small round blue cell ..
  42. Gu X, Cheng M, Herrera G. Kidney carcinoid tumor: Histological, immunohistochemical and ultrastructural features. Ultrastruct Pathol. 2017;:1-5 pubmed publisher
    ..These morphological variations may mimic other benign and malignant primary neoplasms in the kidney...
  43. Sutradhar R, Lokku A, Barbera L. Cancer survivorship and opioid prescribing rates: A population-based matched cohort study among individuals with and without a history of cancer. Cancer. 2017;123:4286-4293 pubmed publisher
    ..This raises concerns about the diagnosis and management of chronic pain problems among survivors stemming from their cancer diagnosis or treatment. Cancer 2017;123:4286-4293. © 2017 American Cancer Society. ..
  44. Satoh T, Kaira K, Takahashi K, Takahashi N, Kanai Y, Asao T, et al. Prognostic Significance of the Expression of CD98 (4F2hc) in Gastric Cancer. Anticancer Res. 2017;37:631-636 pubmed
    CD98 expression is high in various human neoplasms. However, the relationship of CD98 expression with the clinicopathological factors of gastric cancer (GC) remains unclear...
  45. Cai J, He B, Li X, Sun M, Lam A, Qiao B, et al. Regulation of tumorigenesis in oral epithelial cells by defined reprogramming factors Oct4 and Sox2. Oncol Rep. 2016;36:651-8 pubmed publisher
    ..The results showed that the doubly transduced (Oct4+Sox2+) cells could trigger neoplasms in immunodeficient mice after lentivirus transduction, but single transduced (Oct4+ or Sox2+) cells had no tumor ..
  46. Oleinikova N, Kharlova O, Mal kov P, Danilova N. [The expression of claudins in colonic neoplasms]. Arkh Patol. 2017;79:28-35 pubmed publisher
  47. Chiang Y, Chang Y, Lin H, Huang L, Cheng C, Wang W, et al. Germline variations at JAK2, TERT, HBS1L-MYB and MECOM and the risk of myeloproliferative neoplasms in Taiwanese population. Oncotarget. 2017;8:76204-76213 pubmed publisher
    ..i>TERT, HBS1L-MYB and MECOM have been found to associate with myeloproliferative neoplasms (MPNs) in European populations...
  48. Rahman Sayed H, Sedky M, Hamoda A, Kinaaie N, Wakeel M, Hesham D. Results of treatment of lymphoblastic lymphoma at the children cancer hospital Egypt - A single center experience. J Egypt Natl Canc Inst. 2016;28:175-81 pubmed publisher
    Introduction Lymphoblastic lymphoma (LBL) and acute lymphoblastic leukemia (ALL) are neoplasms of immature B or T-cell precursors...
  49. Kirikoshi H, Saito S, Ueno N, Suzuki K, Takahashi H, Yoneda M, et al. Evaluation of hepatocellular carcinoma with portal vein tumor thrombosis by CEUS before and after hepatic arterial infusion chemotherapy. J Med Ultrason (2001). 2010;37:137-41 pubmed publisher
    Hepatocellular carcinoma (HCC) is one of the most common neoplasms worldwide. Portal vein tumor thrombosis (PVTT) is a common complication of advanced HCC, and the prognosis of advanced HCC with PVTT is extremely poor...
  50. Hall C, Ritz B, Cockburn M, Davidson T, Heck J. Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics. Cancer Epidemiol. 2017;46:42-49 pubmed publisher
    Childhood germ cell tumors (GCTs) are a rare assortment of neoplasms, with mostly unknown etiology, that are believed to originate very early in life...
  51. Towers C, Thorburn A. Therapeutic Targeting of Autophagy. EBioMedicine. 2016;14:15-23 pubmed publisher
    ..inhibition with Chloroquine or Hydroxychloroquine in combination with other drugs for the treatment of multiple neoplasms. Here, we review recent literature implicating autophagy in neurodegenerative diseases and cancer and highlight ..
  52. Barbui T, Thiele J, Gisslinger H, Kvasnicka H, Vannucchi A, Guglielmelli P, et al. The 2016 WHO classification and diagnostic criteria for myeloproliferative neoplasms: document summary and in-depth discussion. Blood Cancer J. 2018;8:15 pubmed publisher
    ..Under the category of myeloproliferative neoplasms (MPNs), the revised document includes seven subcategories: chronic myeloid leukemia, chronic neutrophilic ..
  53. Katzke V, Sookthai D, Johnson T, Kühn T, Kaaks R. Blood lipids and lipoproteins in relation to incidence and mortality risks for CVD and cancer in the prospective EPIC-Heidelberg cohort. BMC Med. 2017;15:218 pubmed publisher
    ..Thus, the observed cancer risk pattern clearly differs from the CVD risk pattern. ..
  54. Panikkanvalappil S, Hooshmand N, El Sayed M. Intracellular Assembly of Nuclear-Targeted Gold Nanosphere Enables Selective Plasmonic Photothermal Therapy of Cancer by Shifting Their Absorption Wavelength toward Near-Infrared Region. Bioconjug Chem. 2017;28:2452-2460 pubmed publisher
  55. Grellety T, Lucchesi C, Hostein I, Auzanneau C, Khalifa E, Soubeyran I, et al. High-depth sequencing of paired primary and metastatic tumours: Implications for personalised medicine. Eur J Cancer. 2017;84:250-256 pubmed publisher
    ..Up to 40% of paired primary tumour/metastases have discordant molecular profile. Liquid biopsies may overcome, in the near future, the limits of tumour tissue genotyping. ..
  56. Icard P, Teboul B, El Baze P. A Simple Method to Optimize the Effectiveness of Chemotherapy: Modulation of Glucose Intake During Chemotherapy. Anticancer Res. 2017;37:6199-6202 pubmed
    ..We propose to increase the efficiency of chemotherapy by modulating glucose intake during the course of chemotherapy...
  57. Plouhinec J, Medina Ruiz S, Borday C, Bernard E, Vert J, Eisen M, et al. A molecular atlas of the developing ectoderm defines neural, neural crest, placode, and nonneural progenitor identity in vertebrates. PLoS Biol. 2017;15:e2004045 pubmed publisher
  58. Weeber F, Ooft S, Dijkstra K, Voest E. Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery. Cell Chem Biol. 2017;24:1092-1100 pubmed publisher
    ..In this review, we highlight what is currently known about tumor organoid culture, the advantages and challenges of the model system, compare it with other pre-clinical cancer models, and evaluate its value for drug development. ..
  59. Kerr J, Anderson C, Lippman S. Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence. Lancet Oncol. 2017;18:e457-e471 pubmed publisher
  60. Song Y, Yang J. Role of interleukin (IL)-17 and T-helper (Th)17 cells in cancer. Biochem Biophys Res Commun. 2017;493:1-8 pubmed publisher
    ..This review demonstrates an understanding on how the pro- or antitumor function of Th17 cells and IL-17 may change cancer progression, leading to the appearance of complex and pivotal biologic activities in tumor. ..
  61. Kastenhuber E, Lowe S. Putting p53 in Context. Cell. 2017;170:1062-1078 pubmed publisher
    ..interpret p53's disparate activities and the consequences of its dysfunction to understand how cell type, mutation profile, and epigenetic cell state dictate outcomes, and how might we restore its tumor-suppressive activities in cancer? ..
  62. Li D, Xia R, Zhang Q, Bai C, Li Z, Zhang P. Evaluation of candidemia in epidemiology and risk factors among cancer patients in a cancer center of China: an 8-year case-control study. BMC Infect Dis. 2017;17:536 pubmed publisher
    ..Total parenteral nutrition, urinary catheter, distant organ metastasis of cancer and gastrointestinal cancer are independent predictors for candidemia, this findings provides potential therapeutic targets for improving the outcome. ..
  63. Muñoz I, Morel B, Medina Carmona E, Pey A. A mechanism for cancer-associated inactivation of NQO1 due to P187S and its reactivation by the consensus mutation H80R. FEBS Lett. 2017;591:2826-2835 pubmed publisher
    ..Our analyses illustrate how single amino acid changes can profoundly affect structural and mechanistic features of protein functional traits, with implications for our understanding of protein evolution and human disease. ..
  64. Wilson M, Mak W, Firth M, Deva S, Findlay M. Mortality within 30 days of systemic anticancer therapy at a tertiary cancer centre: assessing the safety and quality of clinical care. N Z Med J. 2017;130:63-72 pubmed
    ..As a quality assurance tool, we assessed the 30-day mortality rate at Auckland City Hospital and compared this with international standards...
  65. Khan M, Xiang S, Song Z, Wu M. The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation. EMBO J. 2017;36:3483-3500 pubmed publisher
    ..Collectively, our findings reveal that p53-induced lncRNA TRINGS controls the necrotic pathway and contributes to the survival of cancer cells harboring wild-type p53 under glucose stress. ..
  66. Piñeros M, Ramos W, Antoni S, Abriata G, Medina L, Miranda J, et al. Cancer patterns, trends, and transitions in Peru: a regional perspective. Lancet Oncol. 2017;18:e573-e586 pubmed publisher
    ..The delivery of effective cancer prevention and control measures requires sustained investment in the collection of high-quality data capable of informing policies and driving research programmes. ..
  67. Frary E, Hess S, Gerke O, Laustrup H. 18F-fluoro-deoxy-glucose positron emission tomography combined with computed tomography can reliably rule-out infection and cancer in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis suspected of disease relapse. Medicine (Baltimore). 2017;96:e7613 pubmed publisher
    ..Our study showed FGD-PET/CT's promise as an effective tool for ruling out cancer or infection in patients with AAV albeit in a limited population...
  68. Tsui P, Zhou Z, Lin Y, Hung C, Chung S, Wan Y. Effect of ultrasound frequency on the Nakagami statistics of human liver tissues. PLoS ONE. 2017;12:e0181789 pubmed publisher
    ..Moreover, the coherent scatterers may be the primary factor to dominate the frequency dependence of the backscattered statistics in a liver...
  69. Simard J, Kircher S, Didwania A, Goel M. Screening for Recurrence and Secondary Cancers. Med Clin North Am. 2017;101:1167-1180 pubmed publisher
    ..This article presents surveillance strategies for the most common malignancies...
  70. Strekalova Y, Krieger J. Beyond Words: Amplification of Cancer Risk Communication on Social Media. J Health Commun. 2017;22:849-857 pubmed publisher
    ..This study's findings emphasize the importance of focused investigation of message design strategies and message effects on the dissemination and amplification of communication related to health risks...
  71. Piton N, Lamy A, Sabourin J. [Tumour sequencing: Evolutions and revolutions]. Cancer Radiother. 2017;21:580-583 pubmed publisher
    ..Nevertheless, the current challenge is not anymore detection of molecular alterations, but their relevant interpretation, so as to be the most useful in patient care. ..
  72. Mita M, Mita A, Moseley J, Poon J, Small K, Jou Y, et al. Phase 1 safety, pharmacokinetic and pharmacodynamic study of the cyclin-dependent kinase inhibitor dinaciclib administered every three weeks in patients with advanced malignancies. Br J Cancer. 2017;117:1258-1268 pubmed publisher
    ..This Phase 1 study evaluated the safety, tolerability and pharmacokinetics of various dosing schedules of dinaciclib in advanced solid tumour patients and assessed pharmacodynamic and preliminary anti-tumour activity...
  73. Nakajima K, Nangia Makker P, Hogan V, Raz A. Cancer Self-Defense: An Immune Stealth. Cancer Res. 2017;77:5441-5444 pubmed publisher
    ..i>Cancer Res; 77(20); 5441-4. ©2017 AACR. ..
  74. Suzuki S, Ishikawa N, Konoeda F, Seki N, Fukushima S, Takahashi K, et al. Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan. Neurology. 2017;89:1127-1134 pubmed publisher
    ..Immune-related adverse events triggered by nivolumab impaired the patients' daily living activity. The prompt and correct recognition of MG following treatment with immune checkpoint inhibitors in patients with cancer is important. ..
  75. Martina F, Beccuti M, Balbo G, Cordero F. Peculiar Genes Selection: A new features selection method to improve classification performances in imbalanced data sets. PLoS ONE. 2017;12:e0177475 pubmed publisher
    ..The download of the package with the implementation of Peculiar Genes Selection, 'PGS', is available for R users at: