biological models

..immunosuppression, immunotherapy, kidney transplantation, leukocyte depletion therapy, transplant rejection biological model, busulfan, cell population study, homologous transplantation, immunologic substance development /preparation, ..

..We are testing this hypothesis utilizing several biological models, including AD patients? post-mortem tissue...

..And, as a biological model, we will explore the way in which exposure to Helicobacter pylori, may impact these signals and affect ..

..The proposed research program is integrated scientifically by a biological model that hypothesizes that chronic oxidative and nitrosative stress mediate the chronic effects of air pollution ..

..2) evaluate the utility of molecular biomarkers/biosensors, microtechnologies and bioremediation as new biological models/methods for improving environmental monitoring, risk assessment and remediation; 3) organize technology ..

..ii) Characterize Drug Release and Delivery Performance of Particles for CF Therapy in vitro and in biological models relevant to CF disease, and (iii) Evaluate in vivo efficacy of sustained release pulmonary delivery system ..

..ii) Characterize Drug Release and Delivery Performance of Particles for CF Therapy in vitro and in biological models relevant to CF disease, and (iii) Evaluate in vivo efficacy of sustained release pulmonary delivery system ..

..The biological model that underlies the proposed epidemiological study is that alterations in endothelial function are associated ..

..fundyense populations and the Gulf of Maine coastal current system. Indeed, coupled physical-biological models of population dynamics and hydrodynamic transport are able to simulate some of the general features of the ..

..regulation, cell proliferation, hematopoiesis, hematopoietic stem cell, mathematical model age difference, biological model, cell migration, cell population study, computer simulation, cytogenetics, glucose 6 phosphate dehydrogenase, ..

..Two biological models will be used for the proposed work...

..Two biological models will be used for the proposed work...

..The ultimate goal of this work is to create plausible, principled, and data-based biological models of auditory midbrain, thalamic, and cortical connectivity that incorporate specific projections and local ..

..The ultimate goal of this work is to create plausible, principled, and data-based biological models of auditory midbrain, thalamic, and cortical connectivity that incorporate specific projections and local ..

..Three Specific Aims are designed to use a variety of biological models including a cell-free system, cultured cells and animal models address this hypothesis...

..mechanical loads with Thesaurus Terms: aging, biomechanics, knee, mechanical pressure, mechanical stress biological model, bone development, femur, femur fracture, skeletal stress computed axial tomography, histology, laboratory ..

..define and eventually overcome P-gp-mediated efflux of substrate drugs are hampered by lack of an appropriate biological model. The naturally-occurring, MDR1(mut/mut) canine model described in this proposal is superior to cell culture ..

..radiation, technology /technique development, time resolved data atherosclerosis, atherosclerotic plaque, biological model, cardiovascular disorder risk, computer simulation, elasticity, heart contraction, image processing, model ..

..Public Affairs Workshop); teratogen update on endocrine-active compounds; and the rat inverted yolk sac as a biological model for risk analysis...

..The overall experimental strategy will focus on biological models of acute pulmonary and systemic vascular Injury (in vitro and in vivo) to demonstrate the effectiveness of ..

..The goal of this R21 proposal is to use this two-component network as a relevant biological model to adapt the Chromatin Immunoprecipitation (ChIP) technique for use on an obligate intracellular, cytosol-..

..The overall experimental strategy will focus on biological models of acute pulmonary and systemic vascular Injury (in vitro and in vivo) to demonstrate the effectiveness of ..

..b>Biological models studied at the Institute for Systems Biology will be used to test and validate the label free protein chip ..

..agent performs the best for the specific detection of prostate cancer, we will develop in vitro and in vivo biological models, using human prostate cancer cell lines...

..Public Health Relevance: This Public Health Relevance is not available...

..agent performs the best for the specific detection of prostate cancer, we will develop in vitro and in vivo biological models, using human prostate cancer cell lines...

..Our specific aims are 1) to identify biological models appropriate for the study of regulated sFIt-1 expression, 2) to identify nuclear factors involved in Fit-1 ..

..to conduct the types of phenotype bio-marker mapping studies required to develop and validate both novel biological models of CLL (including predictive bio- markers capable of enabling adaptive therapy) and therapeutic approaches ..

..Based upon the data generated to date a likely biological model for this formation is T-cell mediated damage to the gallbladder wall leading to a progressive loss of ..

..Based upon the data generated to date a likely biological model for this formation is T-cell mediated damage to the gallbladder wall leading to a progressive loss of ..

..Resonance (EPR) spectroscopy will be utilized to study dynamic behavior exhibited by copper in crystals of biological models. Knowledge of dynamic processes in these systems gives important insight into the stability of unusual ..

..in a single low volume (Thesaurus Terms: method development, microdialysis, neuropeptide antibody, biological model, biological transport, corticotropin releasing factor, cyclodextrin, endogenous opioid, model design /..

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..Using cell suspensions as the biological model allows control of all the variables associated with a PDT treatment...

..This is extremely useful for establishing biological models and evaluating new treatment interventions...

..microfluidic culture systems from having a major impact on cancer biology (accessibility, relevance, biological model, efficiency/throughput)...

..Furthermore, E.coli is at the forefront in systems biology as a proof-of-concept biological model to develop new methodologies in bioinformatics, representation and simulation, to overcome challenges in ..

..It also provides a biological model that can be used to characterize a behavior that is only manifest under certain circumstances...

..3) To develop biological models of metastasis-associated gene function to identify critical metastatic signaling pathways...

..Based on this hypothesis, we propose the following specific aims: 1) Develop a biological model to test the role of extracellular matrix proteins and diffusible factors on NSC patterning...

..e. the number of inputs and outputs is limited for ethical and practical reasons. Public Health Relevance: This Public Health Relevance is not available...

..biological consequences in the tissue, up to 3 wk following acute phonotrauma; (3): develop a hybrid physical-biological model of vocal fold inflammation and treatment to identify phonation modalities that should optimize post-traumatic ..

..development /preparation, bone, drug delivery system, osteomyelitis, polymer antiseptic sterilization, biological model, biomaterial interface interaction, biomechanics, cytotoxicity, gentamicin, model design /development, ..

..This proposal takes advantage of a unique biological model and applies a multidisciplinary approach involving immunocytochemistry, fine structure analysis, time-lapse ..

..in cellular signaling and gene expression by Superfund site chemicals can be exploited to develop biological models for the detection and bioremediation of chemical toxicants'...

..e. the number of inputs and outputs is limited for ethical and practical reasons...

..The biological models developed in projects 1 and 3 will be utilized to select, verify and validate new targets for a growing ..

..Throughout the grant cycle, we will apply these emerging methods to biological models and clinical problems in order to characterize and quantify the precise structural and functional origins of ..

..My primary long-term goal is to use a comprehensive biological model to understand interactions between the immune system and sleep patterns and examine the potential for ..

..My primary long-term goal is to use a comprehensive biological model to understand interactions between the immune system and sleep patterns and examine the potential for ..

..microfluidic culture systems from having a major impact on cancer biology (accessibility, relevance, biological model, efficiency/throughput)...

..the biological experiments are motivated by data needed for modeling and estimation, and mathematical methods are based on the observed biological model behavior. Public Health Relevance: This Public Health Relevance is not available.

..in reasonable time with small amounts of radioactivity and with radiation doses that do not perturb the biological model. The goal of the proposed research is to investigate a novel detector design to build a high performance ..

..mouse core facility is to serve the investigators in this program project by providing them with access to biological models to test the tumorigenicity of prostate carcinoma in vivo...

..neurobiology, neural inhibition, neural plasticity, synaptogenesis, visual cortex, visual deprivation axon, biological model, diazepam, electromagnetic radiation, gamma aminobutyrate, genetic model, neuroanatomy, protein isoform ..

..circulatory assist, induced hypothermia, nonhuman therapy evaluation, therapy design /development biological model, biomaterial development /preparation, heart /lung bypass, resuscitation, sodium bicarbonate blood chemistry,..

..plan of this project is to establish an animal model for RLS, but the immediate focus is to establish a biological model for exploring the relationship of iron to the dopaminergic system...

..modulate the neural bases of higher cognitive processes; prefrontal hemispheric differences in emotion; and biological models of personality and fluid intelligence...

..with combined LCM and protein technologies using control tissue/serum and one preneoplastic stage of the biological model system...

..The parallel architecture of FPGAs, which can simulate the basic reaction steps of biological networks, attains simulation rates at least an order of magnitude greater than currently available microprocessors...

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..Temperature compensation of oscillation period could be simulated if temperature elevation slowed PER nuclear entry or PER phosphorylation. The model makes experimental predictions, some of which could be tested in transgenic Drosophila...

..Moreover, ligand dimerization is shown to potentially regulate FGF-2 activity by shifting the distribution of signaling complexes from the less stable triads to the more stable double triads...

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..The visualisation system has been tested with data from the BRITE database...

..SEEDY provides the complementary ability to perform a directed search based on proteins of interest. AVAILABILITY: SEEDY software (Perl source), data tables and confidence score models (R source) are freely available from the author...

..AVAILABILITY: The software could be freely downloaded from the site: http://bq.ub.es/bioqint/label_distribution/...

..Thus, a combination of computer modeling methods to capture the complexity and details, and useful abstractions revealed by these models, is necessary to achieve both rigorous description as well as human understanding...

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..In addition, generative inverse modeling correctly identifies a known oncogene in a purely data-driven way...

..Developing symbolic models of signalling proteins containing functional domains is important because of the potential to generate analyses of complex signalling networks based on structure-function relationships...

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..These results are consistant with genotype differences in mitochondia and chloroplasts...

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..We conduct Monte Carlo simulations to show the effectiveness of the proposed method. We analyze Saccharomyces cerevisiae gene expression data as an application...

..We show how this comparative framework can facilitate the recovery of the networks and improve the quality of the solutions inferred...

..Our results corroborate previous findings and extend predictions for three processes in atherosclerosis: aberrant lipid metabolism, inflammation, and tissue development and maintenance...

..g. c-Fos, Egr1, and LRG21). The interplay of the activators, repressors, and feedback inhibitors identified embodies a combinatorial code to direct the activity of specific downstream secondary genes...

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..We conclude that the NatB-dependent acetylation of Tfs1p appears to be essential for its inhibitory activity on CPY as well its role in regulating the PKA pathway...

..Importantly, the stochastic and compartmental nature of the simulation allows these models to be directly tested by high-throughput approaches, such as quantitative image analysis...

..Since there is less restriction on the network structure of a MTN, it can be expected to apply to a wide variety of areas on the modelling, analysing and designing of biological systems...

..Taken together, these data show that even short cytoplasmic tails can influence markedly class I MHC mobility and that cytoplasmic tail length and sequence affect the molecule's diffusion in the membrane...

..Thus, dynamic modeling of signaling pathways can promote functional understanding at the systems level...

..The unique in vitro catalytic activity and detailed biochemical and kinetic analyses reported here will be of great value in our continued efforts to identify in vivo substrate(s) for this highly conserved phosphatase...

..CD40 and CD120b used primarily divergent mechanisms to activate NF-kappaB, exemplifying how TNFR family members can use diverse mechanisms to mediate similar downstream events...

..These data provide novel insights into the mechanisms whereby the beta subunit, the I-II loop, and the III-IV loop altogether can contribute to regulate inactivation in high voltage-activated calcium channels...

..In summary, the two splice forms show, despite only a four-amino acid sequence difference, remarkable differences in their signaling capabilities...

..These results implicate an antiapoptotic role for NIPA in NPM-ALK-mediated signaling events...

..By considering calcium stores as idealised point sources we are able to explicitly construct solutions of the FDF model that correspond to saltatory periodic travelling waves...

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..69 vs. 11.47 +/- 1.69 [10(-2) ml kg(-1) min(-1)/ (microU ml(-1))]. The SAAM II vs. ADAPT II estimates are virtually identical (P > 0.44 and 0.68 for S(G) and S(I), respectively) and also closely correlated (p = 0.9998 and 0.9999)...

..A preliminary report of these experiments has been published (Kratzer MAA, Platelets 2002; 13: 344)...

..In future work, the model can serve as a component for studying macroscopic mechanisms of excitation propagation, metabolism, and electromechanics in human myocardium...

..These findings demonstrated that coupling of Gab1 to PI3K is important for biological responses in RET-expressing cells...

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..We use wavelet transform as an analytic tool for fluctuating currents and parametric dispersion plots as a measure of model compatibility with experimental data...

..Altogether, we have identified a minimal peptide that inhibits Stat3 signaling and provides the conceptual basis for use of this peptide as a lead for novel peptidomimetic drug design...

..Together our results provide a novel function for SHP-2 as a positive regulator of cytokine receptor signaling by regulating ubiquitination/degradation pathways...

..The simulations further showed that a descending metabolic intrinsic clearance yielded a lower F and an ascending segmental distribution of metabolic intrinsic clearance yielded a higher F...

..Taken together, our data indicate that box 3 of IL-1RAcP is critical for IL-1-dependent NF-kappaB activation and stabilization of IL-2 mRNA via JNK, whereas aa 527-534 largely contribute to IL-2 promoter activation...

..We discuss the clinical implications and limitations of these results...

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..We identified an S120A/T121A mutant in binding site III, which lacks any signaling capacity, but which still binds to CRH2 with wild type affinity. This leptin mutant behaves as a potent leptin antagonist both in vitro and in vivo...

..After validation in simulated examples, the methods have been applied to add missing loops or domains to several proteins where partial structures were available...

..It is also found that the scaling function is given by the q-exponential function appearing in nonextensive statistical mechanics, showing power-law decay of event correlation in natural time...

..The results witness to the successful performance of the proposed algorithm in quantitative pathogenesis of diseases and comparative evaluation of treatment methods...

..We demonstrate these strengths via experiments on synthesized and real image data...

..The numerical and experimental model analysis showed that the value of mass, stiffness and frequency were very reasonable and that the computed acceleration and measured acceleration matched very well...

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..Model/data comparisons showed good agreement and good predictive power, suggesting that preconditioning can be integrated into comprehensive material characterization of tendons...

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..We investigate the robustness of the network structure to random damages and to deliberate removal of the most important parts of the system and show a surprising tolerance of gene expression networks to both kinds of disturbance...

..On the other side, important protein 'tactilizing' properties are not tapped by the model, and this suggests further complexity steps to explore in the approach to biological molecular computing...

..In contrast, expression levels of genes encoding enzymes in the ED and EMP pathways were not affected by phosphate limitation...

..Therefore, the WPCA model will focus more on the natural variation in the data. AVAILABILITY: M-files for MATLAB for the algorithm used in this research are available at http://www-its.chem.uva.nl/research/pac/Software/pcaw.zip...