Summary: The application of LUBRICANTS to diminish FRICTION between two surfaces.

Top Publications

  1. Sorkin R, Kampf N, Dror Y, Shimoni E, Klein J. Origins of extreme boundary lubrication by phosphatidylcholine liposomes. Biomaterials. 2013;34:5465-75 pubmed publisher
    ..Overall liposome lubrication ability improves markedly with increasing acyl chain length, and correlates strongly with the liposomes' ..
  2. Sturdee D, Panay N. Recommendations for the management of postmenopausal vaginal atrophy. Climacteric. 2010;13:509-22 pubmed publisher
  3. Begay O, Jean Pierre N, Abraham C, Chudolij A, Seidor S, Rodriguez A, et al. Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro. AIDS Res Hum Retroviruses. 2011;27:1019-24 pubmed publisher
    ..In addition, the epithelial damage caused by these and many other lubricants may have implications for enhancing HIV transmission in vivo. These data emphasize the importance of performing more rigorous safety testing on these products. ..
  4. Greene G, Banquy X, Lee D, Lowrey D, Yu J, Israelachvili J. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc Natl Acad Sci U S A. 2011;108:5255-9 pubmed publisher
    ..Although many different lubrication mechanisms have been proposed, it is becoming increasingly apparent that the tribological performance of ..
  5. St Dennis J, Jin K, John V, Pesika N. Carbon microspheres as ball bearings in aqueous-based lubrication. ACS Appl Mater Interfaces. 2011;3:2215-8 pubmed publisher
  6. Myant C, Underwood R, Fan J, Cann P. Lubrication of metal-on-metal hip joints: the effect of protein content and load on film formation and wear. J Mech Behav Biomed Mater. 2012;6:30-40 pubmed publisher
    ..Thus film formation in MoM hip joints is very susceptible to high contact pressures which might be due to implant misalignment and edge-loading. ..
  7. Beyrer C, Sullivan P, Sanchez J, Dowdy D, Altman D, Trapence G, et al. A call to action for comprehensive HIV services for men who have sex with men. Lancet. 2012;380:424-38 pubmed publisher
    ..To address HIV in MSM will take continued research, political will, structural reform, community engagement, and strategic planning and programming, but it can and must be done. ..
  8. Bishop N, Hothan A, Morlock M. High friction moments in large hard-on-hard hip replacement bearings in conditions of poor lubrication. J Orthop Res. 2013;31:807-13 pubmed publisher
    ..clinical results for large diameter metal replacement bearings for the hip are related to compromised lubrication due to poor cup placement, which increases wear as well as friction moments...
  9. Fan J, Myant C, Underwood R, Cann P. Synovial fluid lubrication of artificial joints: protein film formation and composition. Faraday Discuss. 2012;156:69-85; discussion 87-103 pubmed
    ..Clearly it is important to understand the fundamental lubrication mechanisms which control the wear process...

More Information


  1. Kobayashi M, Terada M, Takahara A. Polyelectrolyte brushes: a novel stable lubrication system in aqueous conditions. Faraday Discuss. 2012;156:403-12; discussion 413-34 pubmed
    ..of the brush was prevented owing to the good affinity of the poly(SPMK) brush for water forming a water lubrication layer, and electrostatic repulsive interactions among the brushes bearing sulfonic acid groups...
  2. Flanagan S, Jones E, Birkinshaw C. In vitro friction and lubrication of large bearing hip prostheses. Proc Inst Mech Eng H. 2010;224:853-64 pubmed
    ..The study detailed here used a hip friction simulator to assess the friction and lubrication properties of large-diameter hip bearings of metal-on-metal and ceramic-on-reinforced-polymer couplings...
  3. Bazmamoun H, Ghorbanpour M, Mousavi Bahar S. Lubrication of circumcision site for prevention of meatal stenosis in children younger than 2 years old. Urol J. 2008;5:233-6 pubmed
    ..8 +/- 1.2 days, while it was 6.9 +/- 4.2 days in the control group (P = .03). Based on the findings of this study, it seems logical to use a lubricant jelly for reducing postcircumcision meatal stenosis and other complications. ..
  4. Jones D, Weiss S, Chitalu N, Mumbi M, Shine A, Vamos S, et al. Acceptability and use of sexual barrier products and lubricants among HIV-seropositive Zambian men. AIDS Patient Care STDS. 2008;22:1015-20 pubmed publisher
  5. Yakubov G, McColl J, Bongaerts J, Ramsden J. Viscous boundary lubrication of hydrophobic surfaces by mucin. Langmuir. 2009;25:2313-21 pubmed publisher
    ..It was found that mucin facilitates lubrication between hydrophobic PDMS surfaces, leading to a 10-fold reduction in boundary friction coefficient for rough ..
  6. Pongprasobchai S, Jiranantakan T, Nimmannit A, Nopmaneejumruslers C. Comparison of the efficacy between lidocaine spray plus lidocaine jelly lubrication and lidocaine jelly lubrication alone prior to nasogastric intubation: a prospective double-blind randomized controlled study. J Med Assoc Thai. 2007;90 Suppl 2:41-7 pubmed
    ..randomized controlled study to compare a commercial-available 10% lidocaine spray plus 2% lidocaine jelly lubrication and 2% lidocaine jelly lubrication alone prior to NG intubation...
  7. Chen M, Briscoe W, Armes S, Klein J. Lubrication at physiological pressures by polyzwitterionic brushes. Science. 2009;323:1698-701 pubmed publisher
    ..0004 at pressures as high as 7.5 megapascals. This extreme lubrication is attributed primarily to the strong hydration of the phosphorylcholine-like monomers that make up the ..
  8. Wong B, Kim S, Antonacci J, McIlwraith C, Sah R. Cartilage shear dynamics during tibio-femoral articulation: effect of acute joint injury and tribosupplementation on synovial fluid lubrication. Osteoarthritis Cartilage. 2010;18:464-71 pubmed publisher
    ..Since HA partially restores the function of AI-SF, as indicated by E(xz), tribosupplements may be beneficial in modulating normal cartilage homeostasis. ..
  9. Sivan S, Schroeder A, Verberne G, Merkher Y, Diminsky D, Priev A, et al. Liposomes act as effective biolubricants for friction reduction in human synovial joints. Langmuir. 2010;26:1107-16 pubmed publisher liquid-disordered phase transition temperature slightly below physiological temperature are optimal for lubrication. High phospholipid headgroup hydration, high compressibility, and softness are the common denominators of all ..
  10. Dave M, Koepfer N, Madjdpour C, Frotzler A, Weiss M. Tracheal fluid leakage in benchtop trials: comparison of static versus dynamic ventilation model with and without lubrication. J Anesth. 2010;24:247-52 pubmed publisher
    ..This study compared the potential of a static and dynamic ventilation benchtop model and cuff lubrication in testing the tracheal sealing properties of a given TT cuff. Static trial Six brands of 7...
  11. Akpek E, Lindsley K, Adyanthaya R, Swamy R, Baer A, McDonnell P. Treatment of Sjögren's syndrome-associated dry eye an evidence-based review. Ophthalmology. 2011;118:1242-52 pubmed publisher
    ..Although oral hydroxychloroquine is commonly prescribed to patients with SS to alleviate fatigue and arthralgias, the literature lacks strong evidence for the efficacy of this treatment for dry eye. ..
  12. Dezzutti C, Brown E, Moncla B, Russo J, Cost M, Wang L, et al. Is wetter better? An evaluation of over-the-counter personal lubricants for safety and anti-HIV-1 activity. PLoS ONE. 2012;7:e48328 pubmed publisher
    ..The two iso-osmolar lubricants, Good Clean Love and PRÉ, and both silicone-based lubricants, Female Condom 2 lubricant and Wet Platinum, were the safest in our testing algorithm. ..
  13. Gorbach P, Weiss R, Fuchs E, Jeffries R, Hezerah M, Brown S, et al. The slippery slope: lubricant use and rectal sexually transmitted infections: a newly identified risk. Sex Transm Dis. 2012;39:59-64 pubmed publisher
    ..Because of wide use of lubricants and their potential as carrier vehicles for microbicides, further research is essential to clarify if lubricant use poses a public health risk. ..
  14. Kassler A, Pittenauer E, Doerr N, Allmaier G. CID of singly charged antioxidants applied in lubricants by means of a 3D ion trap and a linear ion trap-Orbitrap mass spectrometer. J Mass Spectrom. 2011;46:517-28 pubmed publisher
    ..For characterizing degradation products of antioxidants, the LIT-Orbitrap hybrid system, allowing the determination of accurate m/z values for product ions, is the method of choice. ..
  15. Bermúdez M, Jiménez A, Sanes J, Carrión F. Ionic liquids as advanced lubricant fluids. Molecules. 2009;14:2888-908 pubmed publisher
    ..Some emerging fields are those of lubrication, surface engineering and nanotechnology...
  16. Spirin L, Galuschko A, Kreer T, Johner A, Baschnagel J, Binder K. Polymer-brush lubrication in the limit of strong compression. Eur Phys J E Soft Matter. 2010;33:307-11 pubmed publisher
    ..In agreement with our theory, the simulation reveals simple power laws, R ? W (0.53), ? ? W (-0.46), and F ? W (0.54), for the non-Newtonian regime. ..
  17. Hoffman S, Morrow K, Mantell J, Rosen R, Carballo Dieguez A, Gai F. Covert use, vaginal lubrication, and sexual pleasure: a qualitative study of urban U.S. Women in a vaginal microbicide clinical trial. Arch Sex Behav. 2010;39:748-60 pubmed publisher
    ..trial of tenofovir gel, a candidate microbicide, we explored the intersection of sexual pleasure and vaginal lubrication to understand whether and under what circumstances women would use a microbicide gel covertly with primary ..
  18. Jones H, Chaikummao S, van de Wijgert J, Friedland B, Manopaiboon C, Witwatwongwana P, et al. Acceptability of a carrageenan-based candidate vaginal microbicide and matching placebo: findings from a phase II safety trial among women in Chiang Rai, Thailand. J Womens Health (Larchmt). 2009;18:1003-10 pubmed publisher
    ..Focusing on enhanced sexual pleasure and lubrication may be beneficial for marketing proven microbicides...
  19. Minami I. Ionic liquids in tribology. Molecules. 2009;14:2286-305 pubmed publisher
    ..from 1,3-dialkylimidazolium, with a higher alkyl group on the imidazolium cation being beneficial for good lubrication, while it reduces the thermo-oxidative stability...
  20. Goda T, Konno T, Takai M, Ishihara K. Photoinduced phospholipid polymer grafting on Parylene film: advanced lubrication and antibiofouling properties. Colloids Surf B Biointerfaces. 2007;54:67-73 pubmed
    ..To provide lubrication and an antibiofouling surface, a biomimetic phospholipid polymer--poly(2-methacryloyloxyethyl phosphorylcholine ..
  21. Smith S, Dowson D, Goldsmith A. The effect of femoral head diameter upon lubrication and wear of metal-on-metal total hip replacements. Proc Inst Mech Eng H. 2001;215:161-70 pubmed
    ..The joints were subject to dynamic motion and loading cycles simulating walking for both lubrication and wear studies...
  22. Hills B. Boundary lubrication in vivo. Proc Inst Mech Eng H. 2000;214:83-94 pubmed
    Evidence is reviewed for the concept that the body employs essentially the same lubrication system in many sites in the body where tissues slide over each other with such ease...
  23. Liao Y, Benya P, McKellop H. Effect of protein lubrication on the wear properties of materials for prosthetic joints. J Biomed Mater Res. 1999;48:465-73 pubmed
    ..The results indicated directions for further research to clarify the lubricating properties of serum, and for developing a universal standard test lubricant. ..
  24. Nguyen D, Lee H, Poast J, Cloyd M, Baron S. Preventing sexual transmission of HIV: anti-HIV bioregulatory and homeostatic components of commercial sexual lubricants. J Biol Regul Homeost Agents. 2004;18:268-74 pubmed
    ..Furthermore, clinical trials of these lubricants and components seem to be indicated because of their FDA safety level, wide availability, and low cost. ..
  25. Oates K, Krause W, Jones R, Colby R. Rheopexy of synovial fluid and protein aggregation. J R Soc Interface. 2006;3:167-74 pubmed
    ..Protein aggregation appears to play an important role in the mechanical properties of blood and synovial fluid. We also suggest a connection between the observed rheopexy and the remarkable lubrication properties of synovial fluid.
  26. Becchi M, Perret F, Carraze B, Beziau J, Michel J. Structural determination of zinc dithiophosphates in lubricating oils by gas chromatography-mass spectrometry with electron impact and electron-capture negative ion chemical ionization. J Chromatogr A. 2001;905:207-22 pubmed
    ..The diastereoisomer mixtures of 2-hydroxy-sec.-alkyl radicals were completely separated on GC analysis. ..
  27. Caligaris M, Ateshian G. Effects of sustained interstitial fluid pressurization under migrating contact area, and boundary lubrication by synovial fluid, on cartilage friction. Osteoarthritis Cartilage. 2008;16:1220-7 pubmed publisher
    This experimental study tests two hypotheses which address outstanding questions in cartilage lubrication: can the friction coefficient remain low under sustained physiological loading conditions? How effective is synovial fluid (SF) in ..
  28. Schmidt T, Sah R. Effect of synovial fluid on boundary lubrication of articular cartilage. Osteoarthritis Cartilage. 2007;15:35-47 pubmed
    The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes...
  29. Tadmor R, Chen N, Israelachvili J. Thin film rheology and lubricity of hyaluronic acid solutions at a normal physiological concentration. J Biomed Mater Res. 2002;61:514-23 pubmed
    ..beam) interferometry to measure surface shapes and separations (to +/-1 A), the normal, viscous, and shear (lubrication) forces between smooth mica surfaces in aqueous hyaluronic acid (HA) solutions were measured...
  30. Kobayashi M, Oka M. The lubricative function of artificial joint material surfaces by confocal laser scanning microscopy. Comparison with natural synovial joint surface. Biomed Mater Eng. 2003;13:429-37 pubmed
    ..under the physiological loading by confocal laser scanning microscopy (CLSM) to clarify the mechanism of lubrication in natural joints and subsequently improve the quality of artificial joints...
  31. Krishnan R, Kopacz M, Ateshian G. Experimental verification of the role of interstitial fluid pressurization in cartilage lubrication. J Orthop Res. 2004;22:565-70 pubmed
    ..Fitting the experimental data to a previously proposed biphasic boundary lubrication model for cartilage yielded an equilibrium friction coefficient of mu eq=0.284+/-0.044...
  32. Baron S, Poast J, Nguyen D, Cloyd M. Practical prevention of vaginal and rectal transmission of HIV by adapting the oral defense: use of commercial lubricants. AIDS Res Hum Retroviruses. 2001;17:997-1002 pubmed
    ..S. FDA category, and may be used by recipient women or men, they should be tested in clinical trials to help prevent sexual transmission of HIV. ..
  33. Braunstein S, van de Wijgert J. Preferences and practices related to vaginal lubrication: implications for microbicide acceptability and clinical testing. J Womens Health (Larchmt). 2005;14:424-33 pubmed
    ..Preferences and practices regarding lubrication during sex, therefore, likely influence microbicide acceptability and use...
  34. Lee S, Muller M, Rezwan K, Spencer N. Porcine gastric mucin (PGM) at the water/poly(dimethylsiloxane) (PDMS) interface: influence of pH and ionic strength on its conformation, adsorption, and aqueous lubrication properties. Langmuir. 2005;21:8344-53 pubmed
    ..The lubrication mechanism of the self-mated sliding contact of PDMS by means of surface modification with PGM is discussed in ..
  35. Williams S, Jalali Vahid D, Brockett C, Jin Z, Stone M, Ingham E, et al. Effect of swing phase load on metal-on-metal hip lubrication, friction and wear. J Biomech. 2006;39:2274-81 pubmed
    ..during surgery may alter loading of THRs during the swing phase of gait leading to changes in fluid film lubrication, friction and wear...
  36. Liu F, Jin Z, Roberts P, Grigoris P. Importance of head diameter, clearance, and cup wall thickness in elastohydrodynamic lubrication analysis of metal-on-metal hip resurfacing prostheses. Proc Inst Mech Eng H. 2006;220:695-704 pubmed
    The main design features of metal-on-metal (MOM) hip resurfacing prostheses in promoting elastohydrodynamic lubrication were investigated in the present study, including the femoral head diameter, the clearance, and the cup wall ..
  37. Meyer A, Baier R, Chen H, Chowhan M. Differential tissue-on-tissue lubrication by ophthalmic formulations. J Biomed Mater Res B Appl Biomater. 2007;82:74-88 pubmed
    ..of hydrophilic polymer-containing formulations between the "blinking" tissues would compare with lubrication by saline, alone, or an oil-emulsion preparation...
  38. Briscoe W, Titmuss S, Tiberg F, Thomas R, McGillivray D, Klein J. Boundary lubrication under water. Nature. 2006;444:191-4 pubmed
    Boundary lubrication, in which the rubbing surfaces are coated with molecular monolayers, has been studied extensively for over half a century...
  39. Fuchs E, Lee L, Torbenson M, Parsons T, Bakshi R, Guidos A, et al. Hyperosmolar sexual lubricant causes epithelial damage in the distal colon: potential implication for HIV transmission. J Infect Dis. 2007;195:703-10 pubmed
    ..Because denudation plausibly increases the risk of HIV transmission, hyperosmolar gels make poor rectal microbicide formulations, and hyperosmolar sexual lubricants may increase susceptibility to HIV infection. ..
  40. Carballo Dieguez A, Stein Z, Saez H, Dolezal C, Nieves Rosa L, Diaz F. Frequent use of lubricants for anal sex among men who have sex with men: the HIV prevention potential of a microbicidal gel. Am J Public Health. 2000;90:1117-21 pubmed
    ..Product and dispenser preferences also were discussed. A rectal lubricant with microbicidal properties appears acceptable and desirable to Latino men who have anal sex with other men. ..
  41. Jin Z, Dowson D, Fisher J. Analysis of fluid film lubrication in artificial hip joint replacements with surfaces of high elastic modulus. Proc Inst Mech Eng H. 1997;211:247-56 pubmed
    b>Lubrication mechanisms and contact mechanics have been analysed for total hip joint replacements made from hard bearing surfaces such as metal-on-metal and ceramic-on-ceramic...
  42. Voeller B, Coulson A, Bernstein G, Nakamura R. Mineral oil lubricants cause rapid deterioration of latex condoms. Contraception. 1989;39:95-102 pubmed
    ..Mineral oil-lubricated condoms are risky; however, the nonoxynol gel-treated condom, recommended as an AIDS prevention measure, is water-based and therefore safe. ..
  43. McClure G, Jin Z, Fisher J, Tighe B. Determination of lubricating film thickness for permeable hydrogel and non-permeable polyurethane layers bonded to a rigid substrate with particular reference to cushion form hip joint replacements. Proc Inst Mech Eng H. 1996;210:89-93 pubmed
    ..Comparison of the experimental results and the theoretical predictions based upon elastohydrodynamic lubrication analysis showed good agreement in the entraining experiments where the film thickness was greater than 150 nm...
  44. Nitzan D. The process of lubrication impairment and its involvement in temporomandibular joint disc displacement: a theoretical concept. J Oral Maxillofac Surg. 2001;59:36-45 pubmed
    ..The joint lubrication system and the process of its breakdown are clarified and an attempt is made to evaluate the possible effect of ..
  45. Hills B. Surface-active phospholipid: a Pandora's box of clinical applications. Part II. Barrier and lubricating properties. Intern Med J. 2002;32:242-51 pubmed
    ..Highly desirable properties include boundary lubrication (lubricity), release (antistick) and the ability of the strongly adsorbed and strongly cohesive SAPL linings to ..
  46. Gleghorn J, Jones A, Flannery C, Bonassar L. Boundary mode lubrication of articular cartilage by recombinant human lubricin. J Orthop Res. 2009;27:771-7 pubmed publisher
    b>Lubrication of cartilage involves a variety of physical and chemical factors, including lubricin, a synovial glycoprotein that has been shown to be a boundary lubricant...
  47. Hills B, Crawford R. Normal and prosthetic synovial joints are lubricated by surface-active phospholipid: a hypothesis. J Arthroplasty. 2003;18:499-505 pubmed
    ..This, in turn, leads to the replenishment of SAPL, as tested in OA, and the concept of prelubricating prostheses before implantation. ..
  48. Wang A, Essner A, Schmidig G. The effects of lubricant composition on in vitro wear testing of polymeric acetabular components. J Biomed Mater Res B Appl Biomater. 2004;68:45-52 pubmed
    ..It is recommended that lubricants for simulator testing be standardized to control total protein content as well as albumin/globulin ratio. ..
  49. Skotheim J, Mahadevan L. Soft lubrication. Phys Rev Lett. 2004;92:245509 pubmed
    We consider some basic principles of fluid-induced lubrication at soft interfaces. In particular, we quantify how a soft substrate changes the geometry of and the forces between surfaces sliding past each other...
  50. Graindorge S, Ferrandez W, Jin Z, Ingham E, Grant C, Twigg P, et al. Biphasic surface amorphous layer lubrication of articular cartilage. Med Eng Phys. 2005;27:836-44 pubmed
    ..From the lubrication point of view however, a simple biphasic model is unable to account for the extremely low friction coefficients ..
  51. Jones D, Weiss S, Chitalu N, Bwalya V, Villar O. Acceptability of microbicidal surrogates among Zambian women. Sex Transm Dis. 2008;35:147-53 pubmed
    ..Results illustrate the influence of male partners on Zambian seronegative women's preferences for microbicidal products, and the change in preferred characteristics over time. ..
  52. Lee S, Spencer N. Materials science. Sweet, hairy, soft, and slippery. Science. 2008;319:575-6 pubmed publisher
  53. Fang H, Hsieh M, Huang H, Tsai C, Chang M. Conformational and adsorptive characteristics of albumin affect interfacial protein boundary lubrication: from experimental to molecular dynamics simulation approaches. Colloids Surf B Biointerfaces. 2009;68:171-7 pubmed publisher
    ..joint, it is believed the lubricants form protective layers on the sliding surfaces under the boundary lubrication mechanism...