pharmaceutical chemistry

..The project will be led by scientists in pharmaceutics and pharmaceutical chemistry (S.K. Li, College of Pharmacy, University of Utah), physics and radiology (E-K...

..The project will be led by scientists in pharmaceutics and pharmaceutical chemistry (S.K. Li, College of Pharmacy, University of Utah), physics and radiology (E-K...

..The project will be led by scientists in pharmaceutics and pharmaceutical chemistry (S.K. Li, College of Pharmacy, University of Utah), physics and radiology (E-K...

..For the past 30 years the Department of Pharmaceutical Chemistry at the University of Kansas has had an internationally recognized program for training pharmaceutical ..

..ft. Molecular Sciences Complex. The funds to house faculty members in Neuroscience, Protein Studies, and Pharmaceutical Chemistry will significantly contribute to CNS achieving the following objectives: 1) increase the number of women ..

..The instrument will mainly serve the Departments of Molecular and Cell Biology, Chemistry and Pharmaceutical Chemistry at the University of Connecticut - Storrs campus...

..to provide support for students and post-docs to attend the 16th International Symposium on Radio-pharmaceutical Chemistry which will be held at the University of Iowa, Iowa City, Iowa on June 24 -28, 2005...

..Since the asymmetric synthesis of nitrogen-containing products plays an important role in medicinal and pharmaceutical chemistry, this contribution will ultimately facilitate the discovery of compounds for the treatment of human ..

..perfringens epsilon-toxin. (2) Utilize initial testing data in concert with pharmaceutical chemistry to design and synthesize a biased library of beta- cyclodextrin derivatives with an enhanced affinity to ..

..from synthetic groups, and these people have become leaders in computational understanding of organic and pharmaceutical chemistry. The specific aims for the new grant period are: Aim 1: Development of quantum mechanical methods to ..

..from synthetic groups, and these people have become leaders in computational understanding of organic and pharmaceutical chemistry. The specific aims for the new grant period are: Aim 1: Development of quantum mechanical methods to ..

..It was concluded that proper selection of rate-controlling polymers with release rate modifier excipients will determine overall release profile, duration and mechanism from directly compressed matrices...

..In addition, all sustained release suspensions possessed good stability with low drug leaching and their release profiles were unchanged when compared with the dried microcapsules for 120 days at 30 and 45 degrees C...

..In vivo studies demonstrate extended drug absorption, showing that the matrix tablets do not disintegrate immediately. Nevertheless, acetaminophen does not seem to be the most appropriate drug for this type of formulation...

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..The developed controlled release matrix tablets of lamivudine, with good initial release (20%-25% in first hour) and extension of release up to 16 to 20 hours, can overcome the disadvantages of conventional tablets of lamivudine...

..Pharmacokinetic study in rabbits showed that t(max) was delayed and C(max) lowered compared with tablets C and the values of AUC(0-24 h) of the three tablets were very close...

..63% vol/vol of native dextran B110-1-2 plus initial porosity in the LBD-dextran matrices with a relative polymer/drug particle size of 4.17 were attributed to the existence of an excipient percolation threshold...

..A validated mathematical model is also presented which allows drug release profiles to be reliably predicted based on the initial HPMC and PVP content in the tablet...

..This relationship is valid for different drugs, excipients and systems (inert or hydrophilic matrix tablets)...

..The incorporation of acidic pH modifiers in the controlled release formulation increases the solubility of the basic drug even as the high pH dissolution medium enters into the dosage form hence increasing drug release rate...

..Thus, Eudragit S100 microspheres can be successfully prepared for oral delivery of enzymes with desirable characters in terms of maximum loading and diffusion release pattern...

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..In conclusion, the in vitro release profile and the mathematical models indicate that release of propranolol hydrochloride can be effectively controlled from a single tablet using HPMC K15M or KollidonSR matrix system...

..These profiles could be controlled by conveniently modifying the proportion of the IPEC in the tablets...

..Therefore, the ISM systems are an attractive alternative to existing complicated microencapsulation methods...

..028 C1.5, where C is the concentration of HPMC in the blend...

..The release kinetics was found to be governed by the type and content of the excipients (polymer or filler). The prepared tablets showed no significant change in drug release rate when stored at ambient room conditions for 6 months...

..The bFGF-releasing PEUU scaffolds thus exhibited a combination of mechanical properties and bioactivity that might be attractive for use in cardiovascular and other soft tissue applications...

..However, lactose favored it. The results reveal that programmed drug delivery to achieve pulsatile drug release for three times daily can be obtained from these tablets in capsule system by systemic formulation approach...

..The analysis of the parameter dissolution data after storage at 40 degrees C and 75% RH for 3 months showed, no significant change indicating the two dissolution profiles were considered to be similar (f2 value is more than 50)...

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..Thus, different mass transport mechanisms govern the release of the drug, co-lyophilisation agent and release modifier out of the lipidic implants...

..The results clearly demonstrated the ability of the system to maintain tight blood glucose level and improved the patient compliance by enhancing, controlling and prolonging the systemic absorption of gliclazide...

..In addition, it is expected that these particles arrive at a deep lung epithelium due to low density (high porosity) and limit macrophage recognition because of big particle size (more than 5 microm)...

..The advantages of TFH SLNs are the improved oral bioavailability of TFH and the prolonged mean retention time and drug release time...

..By careful process design, granular microspheres with potential as oral delivery vehicles for bioactive compounds may be developed...

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..The presented nanoparticulate system is a promising carrier for insulin oral delivery since it preserves insulin structure and therefore also, potentially, its bioactivity...

..When compared to the unprotected ATRA, ATRA loaded in PLC-g-mPEG micelles was efficiently protected from photodegradation. This result suggested that loading of ATRA in micelles improved the chemical stability of ATRA...

..In summary, CA MH promoted the miscibility between the drug and Eudragit RS PO during hot-melt extrusion, resulting in the extrusion of an amorphous system with improved dissolution characteristics...

..This study indicates that the dosage forms with similar in vitro dissolution profiles may have a similar in vivo performance, and that this performance could be estimated using appropriate correlation equations...

..These simple statistical tools can allow a formulator to rationally select levels of various components in a formulation, improve the quality of products, and develop more robust processes...

..Results indicate that the release is reproducible and the system has potential for successful scale-up operation, while complying with recommended Food and Drug Administration guidelines "Scale Up and Post Approval Changes"...

..Good agreement was found between the simulated and the experimental data...

..The quadratic mathematical model developed could be used to predict formulations with desired release and floating properties...

..Chemical imaging utilizing NIR detector also demonstrated to show physical changes due to compression differences. In conclusion, sensor technologies can be potentially used to predict physical parameters of the matrix tablets...

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..These predictions need to be validated experimentally...

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..The developed methodology would be beneficial to formulation scientists in dosage form design and optimization...

..Even if the model was already used in literature, the novelty of our approach is to compare model predictions with a complete set of experimental data, confirming that the main phenomena were correctly identified and described...

..In conclusion, SLNs with small particle size, excellent physical stability, high entrapment efficiency, good loading capacity for protein drug can be produced by this novel reverse micelle-double emulsion method in present study...

..The results revealed that after storage in the absence of sunlight for 6 months, the percentages of the remaining curcumin, bisdemethoxycurcumin and demethoxycurcumin were 91, 96 and 88, respectively...

..The study collaborates on the feasibility and suitability of aqueous polymeric drug delivery system, employing statistical design to develop a clinically useful Nanoparticle system with targeting potential...

..A significant increase in size and zeta potential was observed for GTS SLN and WE 85 SLN dispersions stored at 40 degrees C. Release of OL from the SLNs was sustained up to 48 hours in pH 7.4 PB and obeyed Higuchi's release kinetics...

..The oral bioavailability of Tp5 could be enhanced by PBCA nanoparticles. PBCA-Tp5-NP had the property of sustained-release and the efficacy of Tp5 was not changed after formulation...

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..The correlation coefficient (R2 value) was obtained upon fitting the data to Higuchi equation, which signifies that the mechanism of release of celecoxib from the microspheres was diffusion rate-limited...

..These data suggested that PHT containing spray-dried PCL-microcarrier may be a promising drug delivery system for local brain delivery and long-term treatment of pharmacoresistant epilepsy...

..In conclusion, we have formulated a novel surfactant-polymer drug delivery carrier demonstrating sustained release of water-soluble drugs...

..An empirical relationship describing the number of polyelectrolyte layers and time to attain steady-state drug concentration (tau(D)) was developed, where tau(D) increased with increasing polyelectrolyte layers...

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..The validated mathematical model can be used to predict small-molecule drug release from PLG microsphere populations...

..The polymer surface of coated pellets after 12 hours dissolution testing seemed to be shrunk and size of the pellets were also reduced indicating the depletion of reservoir layer...

..The results detailed within this paper indicate that agar is a viable filler for extended release hot melt produced dosage forms...

..In vitro drug release studies showed no significant change during storage for up to 6 months at 25 degrees C/60% relative humidity and 40 degrees C/75% relative humidity...

..Suspension stability was evaluated over 5 months where the particle size remained constant. FT-Raman studies showed the existence of form I within the stable CBZ suspensions...

..The results are consistent with an osmotically driven release mechanism...