chronic pain


Summary: Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.

Top Publications

  1. Li A, Kaptchuk T. The case of acupuncture for chronic low back pain: when efficacy and comparative effectiveness conflict. Spine (Phila Pa 1976). 2011;36:181-2 pubmed publisher
  2. Kmietowicz Z. Acupuncture does not improve chronic knee pain, study finds. BMJ. 2014;349:g5899 pubmed publisher
  3. Checchia G, Letizia Mauro G, Morico G, Oriente A, Lisi C, Polimeni V, et al. Observational multicentric study on chronic sciatic pain: clinical data from 44 Italian centers. Eur Rev Med Pharmacol Sci. 2017;21:1653-1664 pubmed
    ..The results of this study suggest that a multimodal approach based on the association of ALA with physical and pharmacological therapies can be beneficial in the treatment of LBP with sciatica. ..
  4. Battle C, Lovett S, Hutchings H. Chronic pain in survivors of critical illness: a retrospective analysis of incidence and risk factors. Crit Care. 2013;17:R101 pubmed publisher
    b>Chronic pain has been reported in survivors of critical illness for many years after discharge from hospital...
  5. Bronfort G, Hondras M, Schulz C, Evans R, Long C, Grimm R. Spinal manipulation and home exercise with advice for subacute and chronic back-related leg pain: a trial with adaptive allocation. Ann Intern Med. 2014;161:381-91 pubmed publisher
    ..For patients with BRLP, SMT plus HEA was more effective than HEA alone after 12 weeks, but the benefit was sustained only for some secondary outcomes at 52 weeks. U.S. Department of Health and Human Services. ..
  6. Degen R, MacDermid J, Grewal R, Drosdowech D, Faber K, Athwal G. Prevalence of Symptoms of Depression, Anxiety, and Posttraumatic Stress Disorder in Workers With Upper Extremity Complaints. J Orthop Sports Phys Ther. 2016;46:590-5 pubmed publisher
    ..004) and PD (37.5% versus 12.9%, P = .044) compared with other presenting complaints. Similarly, patients with chronic pain had higher rates of depression (54.5% versus 20.1%, P = .006), PD (63.6% versus 12%, P<.001), and PTSD (36...
  7. Palermo T, Holley A. The importance of the family environment in pediatric chronic pain. JAMA Pediatr. 2013;167:93-4 pubmed publisher
  8. Abrams D, Dolor R, Roberts R, Pechura C, Dusek J, Amoils S, et al. The BraveNet prospective observational study on integrative medicine treatment approaches for pain. BMC Complement Altern Med. 2013;13:146 pubmed publisher
    b>Chronic pain affects nearly 116 million American adults at an estimated cost of up to $635 billion annually and is the No. 1 condition for which patients seek care at integrative medicine clinics...
  9. Garcia Palacios A, Herrero R, Belmonte M, Castilla D, Guixeres J, Molinari G, et al. Ecological momentary assessment for chronic pain in fibromyalgia using a smartphone: a randomized crossover study. Eur J Pain. 2014;18:862-72 pubmed
    ..These methods could help clinicians and researchers to gather more accurate ratings of relevant pain-related variables even in populations with low familiarity with technology. ..

More Information

Publications104 found, 100 shown here

  1. Joussellin C. [The management of patients with chronic pain]. Soins. 2017;62:26-29 pubmed publisher
    Managing a patient with chronic pain represents, firstly, a meeting between two people - patient and caregiver - during which a mutual and reciprocal recognition must be built...
  2. Colvin L, Dougherty P. Peripheral neuropathic pain: signs, symptoms, mechanisms, and causes: are they linked?. Br J Anaesth. 2015;114:361-3 pubmed publisher
  3. Johnson E, Dickerson J, Vollmer W, Rowley A, Ritenbaugh C, Deyo R, et al. The feasibility of matching on a propensity score for acupuncture in a prospective cohort study of patients with chronic pain. BMC Med Res Methodol. 2017;17:42 pubmed publisher
    ..The approach offers a new study design option. ..
  4. Gavrilov S, Lebedev I, Son D, Turishcheva O. [Von Korff questionnaire in assessment of social disadaptation and therapeutic results in women with pelvic varicose veins]. Angiol Sosud Khir. 2017;23:97-102 pubmed
  5. Hernon M, Hall A, O Mahony J, Normand C, Hurley D. Systematic Review of Costs and Effects of Self-Management Interventions for Chronic Musculoskeletal Pain: Spotlight on Analytic Perspective and Outcomes Assessment. Phys Ther. 2017;97:998-1019 pubmed publisher
    ..Evidence for the cost-effectiveness of self-management interventions for chronic musculoskeletal pain (CMP) lacks consensus, which may be due to variability in the costing methods employed...
  6. Ballantyne J. Opioids for the Treatment of Chronic Pain: Mistakes Made, Lessons Learned, and Future Directions. Anesth Analg. 2017;125:1769-1778 pubmed publisher
    ..outside the hospital or hospice setting, which strongly implicates the outpatient use of opioids to treat chronic pain. Such abuse and related deaths are occurring in chronic pain patients themselves and also through diversion...
  7. Preston C, Newport R. Analgesic effects of multisensory illusions in osteoarthritis. Rheumatology (Oxford). 2011;50:2314-5 pubmed publisher
  8. Friedrich M. Research yields new insights into mechanisms and treatment of pain. JAMA. 2012;307:239-41 pubmed publisher
  9. Cano T, Morales Quezada J, Bikson M, Fregni F. Methods to focalize noninvasive electrical brain stimulation: principles and future clinical development for the treatment of pain. Expert Rev Neurother. 2013;13:465-7 pubmed publisher
  10. Rosen L, French A, Sullivan G. Complementary, Holistic, and Integrative Medicine: Yoga. Pediatr Rev. 2015;36:468-74 pubmed publisher
  11. Vogler C, Sattovia S, Salazar L, Leung T, Botchway A. Assessing outcomes of educational videos in group visits for patients with chronic pain at an academic primary care clinic. Postgrad Med. 2017;129:524-530 pubmed publisher
    ..Further investigation is needed to evaluate longer-term knowledge retention, sustainability of improvements resulting from the intervention, and longer-term effects of the intervention on functional status. ..
  12. Berlemont C. [The non-pharmacological management of chronic pain]. Soins. 2017;62:38-40 pubmed publisher
    ..Non-pharmacological therapies can also be proposed, notably in relation to chronic pain. Appreciated by patients and developed by caregivers, they require appropriate regulatory guidelines and ..
  13. Liebschutz J, Xuan Z, Shanahan C, Larochelle M, Keosaian J, Beers D, et al. Improving Adherence to Long-term Opioid Therapy Guidelines to Reduce Opioid Misuse in Primary Care: A Cluster-Randomized Clinical Trial. JAMA Intern Med. 2017;177:1265-1272 pubmed publisher
    ..8 (1.6) mg lower than controls (P?<?.001). A multicomponent intervention improved guideline-concordant care but did not decrease early opioid refills. Identifier: NCT01909076. ..
  14. Sibille K, Witek Janusek L, Mathews H, Fillingim R. Telomeres and epigenetics: potential relevance to chronic pain. Pain. 2012;153:1789-93 pubmed publisher
  15. Fan A. The methodology flaws in Hinman's acupuncture clinical trial, Part II: Zelen design and effectiveness dilutions. J Integr Med. 2015;13:136-9 pubmed publisher
  16. Coffin P, Behar E, Rowe C, Santos G, Coffa D, Bald M, et al. Nonrandomized Intervention Study of Naloxone Coprescription for Primary Care Patients Receiving Long-Term Opioid Therapy for Pain. Ann Intern Med. 2016;165:245-52 pubmed publisher
    ..To evaluate the feasibility and effect of implementing naloxone prescription to patients prescribed opioids for chronic pain. 2-year nonrandomized intervention study. 6 safety-net primary care clinics in San Francisco, California...
  17. Lempka S, Malone D, Hu B, Baker K, Wyant A, Ozinga J, et al. Randomized clinical trial of deep brain stimulation for poststroke pain. Ann Neurol. 2017;81:653-663 pubmed publisher
    ..VS/ALIC DBS to modulate the affective sphere of pain represents a paradigm shift in chronic pain management...
  18. Rolin Gilman C, Fournier B, Cleverley K. Implementing Best Practice Guidelines in Pain Assessment and Management on a Women's Psychiatric Inpatient Unit: Exploring Patients' Perceptions. Pain Manag Nurs. 2017;18:170-178 pubmed publisher
    Assessing and managing chronic pain in women with histories of interpersonal trauma, mood disorders and co-morbid addiction is complex...
  19. Zhou M, Yang M, Chen L, Yu C, Zhang W, Ji J, et al. The effectiveness of long-needle acupuncture at acupoints BL30 and BL35 for CP/CPPS: a randomized controlled pilot study. BMC Complement Altern Med. 2017;17:263 pubmed publisher
    ..Needling at the BL30 and BL35 using LA benefits patients with CP/CPPS. The study was registered at the Chinese Clinical Trial Register ( ChiCTR-ICR-15006138 ). ..
  20. Juch J, Maas E, Ostelo R, Groeneweg J, Kallewaard J, Koes B, et al. Effect of Radiofrequency Denervation on Pain Intensity Among Patients With Chronic Low Back Pain: The Mint Randomized Clinical Trials. JAMA. 2017;318:68-81 pubmed publisher
    ..The findings do not support the use of radiofrequency denervation to treat chronic low back pain from these sources. Identifier: NTR3531. ..
  21. Crandall S, Howlett S, Keysor J. Exercise adherence interventions for adults with chronic musculoskeletal pain. Phys Ther. 2013;93:17-21 pubmed publisher
  22. Louw A, Puentedura E, Zimney K, Schmidt S. Know Pain, Know Gain? A Perspective on Pain Neuroscience Education in Physical Therapy. J Orthop Sports Phys Ther. 2016;46:131-4 pubmed publisher
    b>Chronic pain is incredibly complex, and so are decisions as to its treatment...
  23. Vlaeyen J, Linton S. Fear-avoidance model of chronic musculoskeletal pain: 12 years on. Pain. 2012;153:1144-7 pubmed publisher
  24. Kraft B. Is there any clinically relevant cannabinoid-induced analgesia?. Pharmacology. 2012;89:237-46 pubmed publisher
  25. . Chronic Pain: The Need and Hope for Opioid Alternatives. EBioMedicine. 2016;5:1 pubmed publisher
  26. Saariaho A, Saariaho T, Mattila A, Ohtonen P, Joukamaa M, Karukivi M. Alexithymia and depression in the recovery of chronic pain patients: a follow-up study. Nord J Psychiatry. 2017;71:262-269 pubmed publisher
    Childhood adversities and emotional dysregulation are connected with chronic pain, alexithymia, and depression. Longitudinal studies exploring the impact of their co-occurrence on the pain situation are rare...
  27. Hill R. Blocking the effects of NGF as a route to safe and effective pain relief--fact or fancy?. Pain. 2011;152:2200-1 pubmed publisher
  28. Pizzo P, Clark N. Alleviating suffering 101--pain relief in the United States. N Engl J Med. 2012;366:197-9 pubmed publisher
  29. Barnsley L. Whiplash after motor vehicle crashes. BMJ. 2013;347:f5966 pubmed publisher
  30. Tracey I. "Seeing" how our drugs work brings translational added value. Anesthesiology. 2013;119:1247-8 pubmed publisher
  31. Lies J, Lau S, Jones L, Jensen M, Tan G. Predictors and Moderators of Post-traumatic Stress Disorder: An Investigation of Anxiety Sensitivity and Resilience in Individuals with Chronic Pain. Ann Acad Med Singapore. 2017;46:102-110 pubmed
    ..and resilience on the association between trauma history and PTSD symptoms in a sample of individuals with chronic pain. A total of 100 patients with chronic pain were recruited from a large public hospital...
  32. Brauer S, Yoon J, Curlin F. Physician Satisfaction in Treating Medically Unexplained Symptoms. South Med J. 2017;110:386-391 pubmed publisher
    ..57, P = 0.000). Physicians experience less satisfaction in treating conditions characterized by medically unexplained conditions and in treating conditions for which they believe the patient is responsible. ..
  33. DePauw R, Coppieters I, Meeus M, Caeyenberghs K, Danneels L, Cagnie B. Is Traumatic and Non-Traumatic Neck Pain Associated with Brain Alterations? - A Systematic Review. Pain Physician. 2017;20:245-260 pubmed
  34. Kobayashi H, Yamada Y, Morioka S, Niiro E, Shigemitsu A, Ito F. Mechanism of pain generation for endometriosis-associated pelvic pain. Arch Gynecol Obstet. 2014;289:13-21 pubmed
    ..The preponderance of the inflammatory milieu and subsequent hyperinnervation might be involved in the pathophysiology of pain generation in women with endometriosis. ..
  35. Luongo L, Malcangio M, Salvemini D, Starowicz K. Chronic pain: new insights in molecular and cellular mechanisms. Biomed Res Int. 2015;2015:676725 pubmed publisher
  36. Gu W, Shi Z. Staged management of open Lisfranc injury: Experience from 14 patients. Medicine (Baltimore). 2017;96:e6699 pubmed publisher
    ..Temporary K-wire fixation after early radical debridement and realignment will facilitate the definitive internal fixation until soft tissue condition improves, which also can decrease the soft tissue complication. ..
  37. Berta T, Qadri Y, Tan P, Ji R. Targeting dorsal root ganglia and primary sensory neurons for the treatment of chronic pain. Expert Opin Ther Targets. 2017;21:695-703 pubmed publisher
    Currently the treatment of chronic pain is inadequate and compromised by debilitating central nervous system side effects...
  38. De Carolis G, Paroli M, Tollapi L, Doust M, Burgher A, Yu C, et al. Paresthesia-Independence: An Assessment of Technical Factors Related to 10 kHz Paresthesia-Free Spinal Cord Stimulation. Pain Physician. 2017;20:331-341 pubmed
    ..These results suggest that HF10 therapy is not only paresthesia-free, but may be paresthesia-independent. ..
  39. Malfliet A, Leysen L, Pas R, Kuppens K, Nijs J, van Wilgen P, et al. Modern pain neuroscience in clinical practice: applied to post-cancer, paediatric and sports-related pain. Braz J Phys Ther. 2017;21:225-232 pubmed publisher
    In the last decade, evidence regarding chronic pain has developed exponentially. Numerous studies show that many chronic pain populations show specific neuroplastic changes in the peripheral and central nervous system...
  40. Wylde V, Dennis J, Beswick A, Bruce J, Eccleston C, Howells N, et al. Systematic review of management of chronic pain after surgery. Br J Surg. 2017;104:1293-1306 pubmed publisher
    ..Some 66 trials with data from 3149 participants were included. Most trials included patients with chronic pain after spinal surgery (25 trials) or phantom limb pain (21 trials)...
  41. Almeida M, Seal P, Clark R. Challenges in the management of chronic pain in HIV/AIDS. HIV Clin. 2014;26:12-5 pubmed
  42. White A, Cummings M. Acupuncture for knee osteoarthritis: study by Hinman et al represents missed opportunities. Acupunct Med. 2015;33:84-6 pubmed publisher
  43. Zhang Q, Yue J, Lu Y. Acupuncture treatment for chronic knee pain: study by Hinman et al underestimates acupuncture efficacy. Acupunct Med. 2015;33:170 pubmed publisher
  44. Henry S. Evaluating the Risks of Opioid Use for Chronic Pain: Moving Beyond Overdose. J Gen Intern Med. 2016;31:453-4 pubmed publisher
  45. Savigneau G, Soyeux E. [The coordination of community care for patients with chronic pain]. Soins. 2017;62:56-57 pubmed publisher
    Patients with chronic pain require global and multi-disciplinary care. The network "Lutter contre la douleur" offers coordinated support for health professionals and a multidimensional assessment of the patients...
  46. Dorobisz T, Garcarek J, Kurcz J, Korta K, Dorobisz A, Podgórski P, et al. Diagnosis and treatment of pelvic congestion syndrome: Single-centre experiences. Adv Clin Exp Med. 2017;26:269-276 pubmed publisher
    ..syndrome (PCS) that is defined as the presence of varicose of ovarian and pelvic veins associated with chronic pain in the region of the pelvis...
  47. Wang Z, Chang H, Gao Y, Zhang R, Guo Y, Holschneider D, et al. Effects of water avoidance stress on peripheral and central responses during bladder filling in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study. PLoS ONE. 2017;12:e0182976 pubmed publisher
    ..Results are consistent with recent findings in patients with interstitial cystitis, suggesting that WAS may serve as an animal model to elucidate the mechanisms leading to viscerosensitive brain phenotypes in humans with IC/BPS. ..
  48. Hua C, Zehou O, Ducassou S, Minard Colin V, Hamel Teillac D, Wolkenstein P, et al. Sirolimus improves pain in NF1 patients with severe plexiform neurofibromas. Pediatrics. 2014;133:e1792-7 pubmed publisher
    ..The mTOR pathway may be both a major mediator of NF1 tumor growth and regulator of nociceptor sensitivity. mTOR inhibitors clinically used as anticancer and immunosuppressant drugs could be a potential treatment of chronic pain.
  49. Butler D, Callaway E. Scientists in the dark after French clinical trial proves fatal. Nature. 2016;529:263-4 pubmed publisher
  50. Heuch I, Heuch I, Hagen K, Zwart J. Physical activity level at work and risk of chronic low back pain: A follow-up in the Nord-Trøndelag Health Study. PLoS ONE. 2017;12:e0175086 pubmed publisher
    ..Men participating in particularly strenuous work also experienced a higher risk of chronic low back pain. ..
  51. Keifer O, Diaz A, Campbell M, Bezchlibnyk Y, Boulis N. Occipital Nerve Stimulation for the Treatment of Refractory Occipital Neuralgia: A Case Series. World Neurosurg. 2017;105:599-604 pubmed publisher
    Occipital neuralgia is a chronic pain syndrome characterized by sharp, shooting pains in the distribution of the occipital nerves...
  52. Parreira P, Heymans M, van Tulder M, Esmail R, Koes B, Poquet N, et al. Back Schools for chronic non-specific low back pain. Cochrane Database Syst Rev. 2017;8:CD011674 pubmed publisher
    ..While current evidence does not warrant their use, future variants on Back School may have different effects and will need to be studied in future RCTs and reviews. ..
  53. Ueda H, Kurita J, Neyama H, Hirao Y, Kouji H, Mishina T, et al. A mimetic of the mSin3-binding helix of NRSF/REST ameliorates abnormal pain behavior in chronic pain models. Bioorg Med Chem Lett. 2017;27:4705-4709 pubmed publisher
    ..Taken together, these findings show that the chemically optimized mimetic mS-11 can inhibit mSin3-NRSF/REST binding and successfully reverse lost peripheral and central morphine analgesia in mouse models of pain. ..
  54. MacDonald N, Flegel K, Hebert P, Stanbrook M. Better management of chronic pain care for all. CMAJ. 2011;183:1815 pubmed publisher
  55. De Heer E, Dekker J, van Eck van der Sluijs J, Beekman A, van Marwijk H, Holwerda T, et al. Effectiveness and cost-effectiveness of transmural collaborative care with consultation letter (TCCCL) and duloxetine for major depressive disorder (MDD) and (sub)chronic pain in collaboration with primary care: design of a randomized placebo-control. BMC Psychiatry. 2013;13:147 pubmed publisher
    ..However, treatment of chronic pain conditions in depressive patients has, so far, received limited attention in research...
  56. Salt E, Crofford L, SEGERSTROM S. The Mediating and Moderating Effect of Volunteering on Pain and Depression, Life Purpose, Well-Being, and Physical Activity. Pain Manag Nurs. 2017;18:243-249 pubmed publisher
    To improve function and quality of life in patients with chronic pain, a prevalent and costly condition, an understanding of the relationships among well-being, physical activity, depression, and life purpose with pain is needed...
  57. Byrne C, Bowden D, Alkhayat A, Kavanagh E, Eustace S. Sports-Related Groin Pain Secondary to Symphysis Pubis Disorders: Correlation Between MRI Findings and Outcome After Fluoroscopy-Guided Injection of Steroid and Local Anesthetic. AJR Am J Roentgenol. 2017;209:380-388 pubmed publisher
    ..MRI not only is useful in characterizing groin injuries but also may be helpful in predicting response to therapeutic injection. ..
  58. Walk E, Schwartz C, Hidot N, Mazin V, Pochon S, Renaux Bouttier V, et al. [Sleep and nocturnal incontinence in hospital or institutional care]. Soins Gerontol. 2017;22:41-44 pubmed publisher
    ..The results reveal the impact on quality of sleep, the deteriorating management of incontinence with the lenghtening of waiting time and the causes of waking. This discussion process on the quality of sleep must continue. ..
  59. Yamada K, Wakaizumi K, Fukai K, Iso H, Sobue T, Shibata M, et al. Study of chronic pain and its associated risk factors among Japanese industry workers: the Quality of Working Life Influenced by Chronic pain (QWLIC) study. Sangyo Eiseigaku Zasshi. 2017;59:125-134 pubmed publisher
    This study was performed to identify the prevalence, influence, and risk factors associated with chronic pain among Japanese industry workers...
  60. Cramer S, Heller D. Postablation neuroma of the myometrium-a report of 5 cases. Hum Pathol. 2017;67:211-216 pubmed publisher
    ..This may offer gynecologists and their patients an objective finding with a rational, scientific explanation for the pelvic pain. ..
  61. Wylde V, Bruce J, Beswick A, Elvers K, Gooberman Hill R. Assessment of chronic postsurgical pain after knee replacement: a systematic review. Arthritis Care Res (Hoboken). 2013;65:1795-1803 pubmed
    Approximately 20% of patients experience chronic pain after total knee replacement (TKR), yet there is no consensus about how best to assess such pain...
  62. Yang M, Yang J, Zheng H, Wu Q, Zeng F, Liang F. [Comments on "Acupuncture for chronic knee pain: a randomized clinical trial" from Journal of the American Medical Association]. Zhongguo Zhen Jiu. 2015;35:299-304 pubmed
    ..Additionally, enlightenments of this research on further clinical research are summarized. ..
  63. Schechter N, Walco G. The Potential Impact on Children of the CDC Guideline for Prescribing Opioids for Chronic Pain: Above All, Do No Harm. JAMA Pediatr. 2016;170:425-6 pubmed publisher
  64. Rash J, Toivonen K, Robert M, Nasr Esfahani M, Jarrell J, Campbell T. Protocol for a placebo-controlled, within-participants crossover trial evaluating the efficacy of intranasal oxytocin to improve pain and function among women with chronic pelvic musculoskeletal pain. BMJ Open. 2017;7:e014909 pubmed publisher
    ..between oxytocin and pain may differ in women with chronic pelvic musculoskeletal pain relative to other chronic pain conditions because of the abundance of oxytocin receptors in the uterus...
  65. Uyeshiro Simon A, Collins C. Lifestyle Redesign® for Chronic Pain Management: A Retrospective Clinical Efficacy Study. Am J Occup Ther. 2017;71:7104190040p1-7104190040p7 pubmed publisher
    ..was to determine the efficacy of a Lifestyle Redesign® intervention for people living with chronic pain on quality of life (QOL), function, self-efficacy, and pain levels...
  66. Macfarlane G, Barnish M, Jones G. Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis. Ann Rheum Dis. 2017;76:1815-1822 pubmed publisher
    ..Participants reporting 'pain all over the body' for >3 months were compared with persons without chronic pain. Information on death (with cause) was available until mid-2015...
  67. Hinman R, Forbes A, Williamson E, Bennell K. Acupuncture for chronic knee pain: a randomised clinical trial. Authors' reply. Acupunct Med. 2015;33:86-8 pubmed publisher
  68. Toye F, Seers K, Allcock N, Briggs M, Carr E, Barker K. A synthesis of qualitative research exploring the barriers to staying in work with chronic musculoskeletal pain. Disabil Rehabil. 2016;38:566-72 pubmed
    ..integrate qualitative research findings in order to increase our understanding of barriers to stay in work with chronic pain. We searched five electronic bibliographic databases until September 2012, supplemented by citation tracking ..
  69. Wong Y, Smith R, Koppenhaver S. Soft Tissue Mobilization to Resolve Chronic Pain and Dysfunction Associated With Postoperative Abdominal and Pelvic Adhesions: A Case Report. J Orthop Sports Phys Ther. 2015;45:1006-16 pubmed publisher
    Case report. Common complications from abdominal and pelvic surgery include adhesions and chronic pain. Laparoscopic adhesiolysis is sometimes used to reduce adhesions and related pain...
  70. Pan Z, Xue Z, Li G, Sun M, Zhang M, Hao L, et al. DNA Hydroxymethylation by Ten-eleven Translocation Methylcytosine Dioxygenase 1 and 3 Regulates Nociceptive Sensitization in a Chronic Inflammatory Pain Model. Anesthesiology. 2017;127:147-163 pubmed publisher
  71. Shen W, Xu X, Zhai N, Zhou Z, Shao J, Yu Y. Potential mechanisms of microRNA-141-3p to alleviate chronic inflammatory pain by downregulation of downstream target gene HMGB1: in vitro and in vivo studies. Gene Ther. 2017;24:353-360 pubmed publisher
    ..The miR-141-3p expression was increased in rats in the miR-141-3p mimics+HMGB1 shRNA+CFA group. Our study demonstrated that miR-141-3p can alleviate the CIP by downregulating the downstream target gene HMGB1. ..
  72. Morey M. [The pain resource nurse consultation guidelines]. Soins. 2017;62:44-45 pubmed publisher
    ..These describe the circumstances in which a pain resource nurse may intervene and the types of consultation she carries out. ..
  73. Polatin P, Bevers K, Gatchel R. Pharmacological treatment of depression in geriatric chronic pain patients: a biopsychosocial approach integrating functional restoration. Expert Rev Clin Pharmacol. 2017;10:957-963 pubmed publisher
    A recent literature review concluded that the comorbidity of chronic pain and depression in adults is approximately 50%-65%...
  74. Avins A. Needling the status quo. Arch Intern Med. 2012;172:1454-5 pubmed publisher
  75. Cummings M. The development of group acupuncture for chronic knee pain was all about providing frequent electroacupuncture. Acupunct Med. 2012;30:363-4 pubmed publisher
  76. Asmundson G. The emotional and physical pains of trauma: contemporary and innovative approaches for treating co-occurring PTSD and chronic pain. Depress Anxiety. 2014;31:717-20 pubmed publisher
  77. Gautier J, Le Chevalier A. [Territorial resources and access to care in the case of chronic pain]. Soins. 2017;62:51-53 pubmed publisher
    To respond to the complexity of the management of patients with chronic pain, an adapted and structured biopsychosocial approach is necessary...
  78. Eccleston C, Cooper T, Fisher E, Anderson B, Wilkinson N. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Cochrane Database Syst Rev. 2017;8:CD012537 pubmed publisher
    ..b>Chronic pain (that is pain lasting three months or longer) can arise in the paediatric population in a variety of ..
  79. Soon B, Vicenzino B, Schmid A, Coppieters M. Facilitatory and inhibitory pain mechanisms are altered in patients with carpal tunnel syndrome. PLoS ONE. 2017;12:e0183252 pubmed publisher
    ..Although typically considered to be driven by peripheral mechanisms, these findings indicate that CTS demonstrates characteristics of altered central processing with increased pain facilitation and reduced endogenous pain inhibition. ..
  80. Moore A, Derry S, Eccleston C, Kalso E. Expect analgesic failure; pursue analgesic success. BMJ. 2013;346:f2690 pubmed publisher
  81. Richette P. How safe is acetaminophen in rheumatology?. Joint Bone Spine. 2014;81:4-5 pubmed publisher
  82. Schofferman J, Fishman S, Harden R, Kirschner K. Did we reach too far? The opioid epidemic and chronic pain. PM R. 2014;6:78-84 pubmed publisher
  83. Chou R, Turner J, Devine E, Hansen R, Sullivan S, Blazina I, et al. The effectiveness and risks of long-term opioid therapy for chronic pain: a systematic review for a National Institutes of Health Pathways to Prevention Workshop. Ann Intern Med. 2015;162:276-86 pubmed publisher
    Increases in prescriptions of opioid medications for chronic pain have been accompanied by increases in opioid overdoses, abuse, and other harms and uncertainty about long-term effectiveness...
  84. Mamhidir A, Sjölund B, Fläckman B, Wimo A, Sköldunger A, Engström M. Systematic pain assessment in nursing homes: a cluster-randomized trial using mixed-methods approach. BMC Geriatr. 2017;17:61 pubmed publisher
    b>Chronic pain affects nursing home residents' daily life. Pain assessment is central to adequate pain management...
  85. Jegan N, Brugger M, Viniol A, Strauch K, Barth J, Baum E, et al. Psychological risk and protective factors for disability in chronic low back pain - a longitudinal analysis in primary care. BMC Musculoskelet Disord. 2017;18:114 pubmed publisher
    ..There is emerging evidence that focusing on more concrete sub facets like (pain) self-efficacy and acceptance might be more beneficial. German Clinical Trial Register, DRKS00003123 (June 28th 2011). ..
  86. Waugh D, Godfrey M, Limeback H, Potter W. Black Tea Source, Production, and Consumption: Assessment of Health Risks of Fluoride Intake in New Zealand. J Environ Public Health. 2017;2017:5120504 pubmed publisher
    ..We review the international evidence regarding chronic fluoride intake and its association with chronic pain, arthritic disease, and musculoskeletal disorders and provide insights into possible association between ..
  87. Martelletti P, Jensen R, Antal A, Arcioni R, Brighina F, de Tommaso M, et al. Neuromodulation of chronic headaches: position statement from the European Headache Federation. J Headache Pain. 2013;14:86 pubmed publisher
  88. Dzau V, Pizzo P. Relieving pain in America: insights from an Institute of Medicine committee. JAMA. 2014;312:1507-8 pubmed publisher
  89. Chou R, Deyo R, Friedly J, Skelly A, Hashimoto R, Weimer M, et al. Nonpharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline. Ann Intern Med. 2017;166:493-505 pubmed publisher
    ..A 2007 American College of Physicians guideline addressed nonpharmacologic treatment options for low back pain. New evidence is now available...
  90. Fernandez J, Cenador M, Manuel López Millan J, Mendez J, Ledesma M. Use of Information and Communication Technologies in Clinical Practice Related to the Treatment of Pain. Influence on the Professional Activity and the Doctor-Patient Relationship. J Med Syst. 2017;41:77 pubmed publisher
    ..clinical activity is related to one of the greatest social impact health problems which is the treatment of chronic pain. Starting with the completion of a questionnaire, in the study group it is observed that the interaction ..
  91. Cambron J, Dexheimer J, Duarte M, Freels S. Shoe Orthotics for the Treatment of Chronic Low Back Pain: A Randomized Controlled Trial. Arch Phys Med Rehabil. 2017;98:1752-1762 pubmed publisher
    ..Six weeks of prescription shoe orthotics significantly improved back pain and dysfunction compared with no treatment. The addition of chiropractic care led to higher improvements in function. ..
  92. Saper R, Lemaster C, Delitto A, Sherman K, Herman P, Sadikova E, et al. Yoga, Physical Therapy, or Education for Chronic Low Back Pain: A Randomized Noninferiority Trial. Ann Intern Med. 2017;167:85-94 pubmed publisher
    ..Moreover, little is known about yoga's effectiveness in underserved patients with more severe functional disability and pain...