functional laterality


Summary: Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.

Top Publications

  1. Perry C, Fallah M. Effector-based attention systems. Ann N Y Acad Sci. 2017;1396:56-69 pubmed publisher
  2. Posner M, Petersen S. The attention system of the human brain. Annu Rev Neurosci. 1990;13:25-42 pubmed
  3. Schachter S, Ransil B. Handedness distributions in nine professional groups. Percept Mot Skills. 1996;82:51-63 pubmed
    ..These findings are discussed in relation to theories of handedness and cerebral localization of visuospatial and language function. ..
  4. Gehring W, Coles M, Meyer D, Donchin E. A brain potential manifestation of error-related processing. Electroencephalogr Clin Neurophysiol Suppl. 1995;44:261-72 pubmed
  5. Kumar V, Mang S, Grodd W. Direct diffusion-based parcellation of the human thalamus. Brain Struct Funct. 2015;220:1619-35 pubmed
  6. Kim J, Bae S, Lee H, Park J, Kim K. Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality. PLoS ONE. 2017;12:e0182047 pubmed publisher
    ..Taken together, these findings suggest that cldn5a is required for KV lumen inflation and left-right asymmetric organ development. ..
  7. Karvigh S, Motamedi M, Arzani M, Roshan J. HD-tDCS in refractory lateral frontal lobe epilepsy patients. Seizure. 2017;47:74-80 pubmed publisher
    ..Changes of EDs and mean seizure frequency caused by HD-tDCS were not statistically significant for the whole group; however, this method could improve the patients' working memory scores. ..
  8. Palmer A. Animal asymmetry. Curr Biol. 2009;19:R473-7 pubmed publisher
  9. Caselli R, Graff Radford N, Reiman E, Weaver A, Osborne D, Lucas J, et al. Preclinical memory decline in cognitively normal apolipoprotein E-epsilon4 homozygotes. Neurology. 1999;53:201-7 pubmed

More Information


  1. Gaspard N, Manganas L, Rampal N, Petroff O, Hirsch L. Similarity of lateralized rhythmic delta activity to periodic lateralized epileptiform discharges in critically ill patients. JAMA Neurol. 2013;70:1288-95 pubmed
    ..It reflects the presence of a focal lesion and is associated with a high risk of acute seizures, especially nonconvulsive. ..
  2. Luo X, Qiu T, Xu X, Huang P, Gu Q, Shen Z, et al. Decreased Inter-Hemispheric Functional Connectivity in Cognitively Intact Elderly APOE ɛ4 Carriers: A Preliminary Study. J Alzheimers Dis. 2016;50:1137-48 pubmed publisher
    ..71, p <  0.05). In our study, the presence of the APOE ɛ4 allele was linked with decreased inter-hemispheric RSFC, which was attributed to memory performance in carriers. ..
  3. Pixa N, Steinberg F, Doppelmayr M. High-definition transcranial direct current stimulation to both primary motor cortices improves unimanual and bimanual dexterity. Neurosci Lett. 2017;643:84-88 pubmed publisher
    ..The strength of the effects, however, depends on which hand is used in the unimanual task and the type of bimanual task performed. ..
  4. Braem S, De Houwer J, Demanet J, Yuen K, Kalisch R, Brass M. Pattern Analyses Reveal Separate Experience-Based Fear Memories in the Human Right Amygdala. J Neurosci. 2017;37:8116-8130 pubmed publisher
    ..Using two new procedures and recent advances in the analysis of brain imaging data, we localized purely experience-based fear processing and memory in the right amygdala, thereby making a direct link between human and animal research. ..
  5. Warrington E, Pratt R. The significance of laterality effects. J Neurol Neurosurg Psychiatry. 1981;44:193-6 pubmed
    ..The results favour a spatial attention hypothesis rather than a structural hypothesis as the main determinant of laterality effects. ..
  6. Bezdudnaya T, Marchenko V, Zholudeva L, Spruance V, Lane M. Supraspinal respiratory plasticity following acute cervical spinal cord injury. Exp Neurol. 2017;293:181-189 pubmed publisher
  7. Parsons L. Imagined spatial transformations of one's hands and feet. Cogn Psychol. 1987;19:178-241 pubmed
  8. Verwey W, Groen E, Wright D. The stuff that motor chunks are made of: Spatial instead of motor representations?. Exp Brain Res. 2016;234:353-66 pubmed
    ..The between-hand transitions appeared to induce initial segmentation in some of the participants, but this did not consolidate into a concatenation point of successive motor chunks. ..
  9. Üçal M, Haindl M, Adzemovic M, Strasser J, Theisl L, Zeitelhofer M, et al. Widespread cortical demyelination of both hemispheres can be induced by injection of pro-inflammatory cytokines via an implanted catheter in the cortex of MOG-immunized rats. Exp Neurol. 2017;294:32-44 pubmed publisher
    ..Suffering of the animals appeared minor compared to standard Experimental Autoimmune Encephalomyelitis and therefore, even long-term observation and repeated demyelination phases seem ethically acceptable. ..
  10. Baxter L, Schwartz J, Phelps M, Mazziotta J, Guze B, Selin C, et al. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry. 1989;46:243-50 pubmed
    ..With medication for depression (n = 12), the left ALPFC/hem increased significantly and the percentage change in the Hamilton scale score correlated with the percentage change in the left ALPFC/hem.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  11. Chen B, Zheng E, Fan X, Liang T, Wang Q, Wei K, et al. Locomotion mode classification using a wearable capacitive sensing system. IEEE Trans Neural Syst Rehabil Eng. 2013;21:744-55 pubmed publisher
    ..Our investigations demonstrate that capacitive sensing is a promising alternative to myoelectric sensing for real-time control of powered lower-limb prostheses. ..
  12. Stockinger C, Thürer B, Stein T. Consecutive learning of opposing unimanual motor tasks using the right arm followed by the left arm causes intermanual interference. PLoS ONE. 2017;12:e0176594 pubmed publisher
  13. Bruder G, Stewart J, McGrath P. Right brain, left brain in depressive disorders: Clinical and theoretical implications of behavioral, electrophysiological and neuroimaging findings. Neurosci Biobehav Rev. 2017;78:178-191 pubmed publisher
  14. Rogers L, Anson J. Lateralisation of function in the chicken fore-brain. Pharmacol Biochem Behav. 1979;10:679-86 pubmed
    ..A side-preference for response to stimuli seen by the left eye was demonstrated. These results are discussed with reference to head orientation during development in the egg. ..
  15. Bultitude J, Walker I, Spence C. Space-based bias of covert visual attention in complex regional pain syndrome. Brain. 2017;140:2306-2321 pubmed publisher
    ..It is concluded that inattention in near space in complex regional pain syndrome may arise in parallel with a distorted perception of the body.10.1093/brain/awx152_video1awx152media15495542665001...
  16. Meng S, Oi M, Saito G, Saito H. The neural correlates of biomechanical constraints in hand laterality judgment task performed from other person's perspective: A near-infrared spectroscopy study. PLoS ONE. 2017;12:e0183818 pubmed publisher
    ..Furthermore, in the NEG, the PFC activation was not influenced by the BC in either the 1PP or 3PP condition. These results indicate that BC interferes with the HLJ task performed from the 1PP and 3PP. ..
  17. Lee H, Jung S, Lee P, Jeong Y. Altered intrinsic functional connectivity in the latent period of epileptogenesis in a temporal lobe epilepsy model. Exp Neurol. 2017;296:89-98 pubmed publisher
    ..These findings can help enhance our understanding of epileptogenesis, and accordingly, changes in intrinsic functional connectivity can serve as an early diagnosis. ..
  18. Sander D, Klingelhofer J. Changes of circadian blood pressure patterns after hemodynamic and thromboembolic brain infarction. Stroke. 1994;25:1730-7 pubmed
  19. Miletic H, Röhling R, Stenzel W, Deckert M, Benz Bohm G, Berthold F, et al. 8-year-old child with a lesion in the left nucleus lentiformis. Brain Pathol. 2008;18:598-601 pubmed publisher
  20. Imamura T, Ishii K, Hirono N, Hashimoto M, Tanimukai S, Kazuai H, et al. Visual hallucinations and regional cerebral metabolism in dementia with Lewy bodies (DLB). Neuroreport. 1999;10:1903-7 pubmed
    ..The hypometabolism in the primary visual cortex and the relatively preserved metabolism in the right temporoparietal association cortices may be associated with the occurrence of visual hallucinations in DLB patients. ..
  21. Fan R, Enkhjargal B, Camara R, Yan F, Gong L, ShengtaoYao -, et al. Critical role of EphA4 in early brain injury after subarachnoid hemorrhage in rat. Exp Neurol. 2017;296:41-48 pubmed publisher
    ..In contrast, Fasudil abolished the effects of rEphx-1. These results suggest that EphA4, a novel and promising target for treatment, exacerbates EBI through an Ephexin-1/ROCK2 pathway after SAH. ..
  22. Bazley F, Maybhate A, Tan C, Thakor N, Kerr C, All A. Enhancement of bilateral cortical somatosensory evoked potentials to intact forelimb stimulation following thoracic contusion spinal cord injury in rats. IEEE Trans Neural Syst Rehabil Eng. 2014;22:953-64 pubmed publisher
    ..Reorganization of forelimb pathways may occur after thoracic SCI, which SSEPs can monitor to aid the development of future therapies. ..
  23. Verkade P, Oestreicher A, Verkleij A, Gispen W. The increase in B-50/GAP-43 in regenerating rat sciatic nerve occurs predominantly in unmyelinated axon shafts: a quantitative ultrastructural study. J Comp Neurol. 1995;356:433-43 pubmed
  24. Uyehara J, Cooper W. Hemispheric differences for verbal and nonverbal stimuli in Japanese- and English-speaking subjects assessed by Tsunoda's method. Brain Lang. 1980;10:405-17 pubmed
  25. Waters S, Wiestler T, Diedrichsen J. Cooperation Not Competition: Bihemispheric tDCS and fMRI Show Role for Ipsilateral Hemisphere in Motor Learning. J Neurosci. 2017;37:7500-7512 pubmed publisher
    ..Collectively, our findings suggest a cooperative rather than a competitive role of the hemispheres and imply that it is most beneficial to harness plasticity in both hemispheres in neurorehabilitation of motor deficits. ..
  26. Daher I, Le Dieu Lugon B, Dourmap N, Lecuyer M, Ramet L, Gomila C, et al. Magnesium Sulfate Prevents Neurochemical and Long-Term Behavioral Consequences of Neonatal Excitotoxic Lesions: Comparison Between Male and Female Mice. J Neuropathol Exp Neurol. 2017;76:883-897 pubmed publisher
    ..MgSO4 never induced short- or long-term deleterious effect on its own. These results also strongly suggest that sex-specific neuroprotection should be foreseen in preterm infants. ..
  27. Geschwind N, Galaburda A. Cerebral lateralization. Biological mechanisms, associations, and pathology: I. A hypothesis and a program for research. Arch Neurol. 1985;42:428-59 pubmed
  28. Jiang W, Duong T, de Lanerolle N. The neuropathology of hyperthermic seizures in the rat. Epilepsia. 1999;40:5-19 pubmed
    ..It shows in particular that, as in the human, only prolonged seizures such as status epilepticus cause a pattern of neurodegeneration similar to that observed in human TLE. ..
  29. Pujol J, Deus J, Losilla J, Capdevila A. Cerebral lateralization of language in normal left-handed people studied by functional MRI. Neurology. 1999;52:1038-43 pubmed
    ..Exclusive right-hemisphere activation rarely occurred in the frontal lobe region studied. ..
  30. Medel Matus J, Reynolds A, Shin D, Sankar R, Mazarati A. Regulation of kindling epileptogenesis by hippocampal Toll-like receptors 2. Epilepsia. 2017;58:e122-e126 pubmed publisher
    ..Immunostaining revealed that LTA-A attenuated the inflammatory response produced by seizures. These findings suggest that the activation of TLR2 in the hippocampus may facilitate limbic epileptogenesis. ..
  31. Wozny T, Lipski W, Alhourani A, Kondylis E, Antony A, Richardson R. Effects of hippocampal low-frequency stimulation in idiopathic non-human primate epilepsy assessed via a remote-sensing-enabled neurostimulator. Exp Neurol. 2017;294:68-77 pubmed publisher
  32. Geffen G, Traub E. Preferred hand and familial sinistrality in dichotic monitoring. Neuropsychologia. 1979;17:527-31 pubmed
  33. Chang Y, Kemmotsu N, Leyden K, Kucukboyaci N, Iragui V, Tecoma E, et al. Multimodal imaging of language reorganization in patients with left temporal lobe epilepsy. Brain Lang. 2017;170:82-92 pubmed publisher
    ..These concurrent structural and functional shifts from left to right may help to mitigate language impairment in LTLE. ..
  34. O Malley H. Assumptions underlying the delayed auditory feedback task in the study of ear advantage. Brain Lang. 1978;5:127-35 pubmed
  35. Eliasson A, Krumlinde Sundholm L, Gordon A, Feys H, Klingels K, Aarts P, et al. Guidelines for future research in constraint-induced movement therapy for children with unilateral cerebral palsy: an expert consensus. Dev Med Child Neurol. 2014;56:125-37 pubmed
    ..Future research should build upon existing knowledge and aim to provide information that will help implement CIMT in various countries with different healthcare resources and organizational structures. ..
  36. Ottomeyer C, Reuter B, Jager T, Rossmanith C, Hennerici M, Szabo K. Aphemia: an isolated disorder of speech associated with an ischemic lesion of the left precentral gyrus. J Neurol. 2009;256:1166-8 pubmed publisher
  37. Karson C, Coppola R, Morihisa J, Weinberger D. Computed electroencephalographic activity mapping in schizophrenia. The resting state reconsidered. Arch Gen Psychiatry. 1987;44:514-7 pubmed
    ..This emphasis can best be ensured by equating the summed spectra from extraocular movement channels of experimental and control groups. ..
  38. Oldfield R. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 1971;9:97-113 pubmed
  39. Learmonth G, Benwell C, Thut G, Harvey M. Age-related reduction of hemispheric lateralisation for spatial attention: An EEG study. Neuroimage. 2017;153:139-151 pubmed publisher
    ..Future studies will need to determine whether this is representative of the normal aging process or an early indicator of neurodegeneration. ..
  40. Perez D, Fuchs B, Epstein J. A case of cotard syndrome in a woman with a right subdural hemorrhage. J Neuropsychiatry Clin Neurosci. 2014;26:E29-30 pubmed publisher
  41. Lomlomdjian C, Múnera C, Low D, Terpiluk V, Solís P, Abusamra V, et al. The right hemisphere's contribution to discourse processing: A study in temporal lobe epilepsy. Brain Lang. 2017;171:31-41 pubmed publisher
    ..Medial and anterior temporal lobe structures appear to link semantic, world knowledge, and social cognition associated areas to construct a contextually related coherent meaning. ..
  42. Mayer H, Korge A. Microsurgical decompression of degenerative lumbar spinal stenosis. Eur Spine J. 2009;18:1989-1990 pubmed publisher
  43. Satz P, Green M. Atypical handedness in schizophrenia: some methodological and theoretical issues. Schizophr Bull. 1999;25:63-78 pubmed
    ..These subtypes may represent neurodevelopmental markers of insult during intrauterine life that are nongenetic in origin. ..
  44. Cardinale R, Shih P, Fishman I, Ford L, Müller R. Pervasive rightward asymmetry shifts of functional networks in autism spectrum disorder. JAMA Psychiatry. 2013;70:975-82 pubmed
    ..Atypical rightward asymmetry may be a pervasive feature of functional brain organization in ASD, affecting sensorimotor, as well as higher cognitive, domains. ..
  45. Schulte L, Allers A, May A. Hypothalamus as a mediator of chronic migraine: Evidence from high-resolution fMRI. Neurology. 2017;88:2011-2016 pubmed publisher
    ..While the more posterior part of the hypothalamus seems to be important for the acute pain stage, the more anterior part seems to play an important role in attack generation and migraine chronification. ..
  46. Floegel M, Kell C. Functional hemispheric asymmetries during the planning and manual control of virtual avatar movements. PLoS ONE. 2017;12:e0185152 pubmed publisher
  47. Makin T, Wilf M, Schwartz I, Zohary E. Amputees "neglect" the space near their missing hand. Psychol Sci. 2010;21:55-7 pubmed publisher
  48. Basu A, Eyre J. A plea for consideration of the less affected hand in therapeutic approaches to hemiplegia. Dev Med Child Neurol. 2012;54:380; author reply 381-2 pubmed publisher
  49. Septien L, Gras P, Giroud M, Didi Roy R, Brunotte F, Pelletier J, et al. [Depression and temporal epilepsy. The possible role of laterality of the epileptic foci and of gender]. Neurophysiol Clin. 1993;23:327-36 pubmed
    ..These results and the vulnerability to depression of left temporal lobe epileptic patients are analyzed. ..
  50. Bjorklund A, Stenevi U, Dunnett S, Iversen S. Functional reactivation of the deafferented neostriatum by nigral transplants. Nature. 1981;289:497-9 pubmed
  51. Groeschel S, Hertz Pannier L, Delion M, Loustau S, Husson B, Kossorotoff M, et al. Association of transcallosal motor fibres with function of both hands after unilateral neonatal arterial ischemic stroke. Dev Med Child Neurol. 2017;59:1042-1048 pubmed publisher
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