Summary: The branch of biology dealing with the effect of light on organisms.

Top Publications

  1. Nagel G, Szellas T, Huhn W, Kateriya S, Adeishvili N, Berthold P, et al. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc Natl Acad Sci U S A. 2003;100:13940-5 pubmed
    ..Finally, we demonstrate that ChR2 may be used to depolarize small or large cells, simply by illumination. ..
  2. Cleaver J. Ultraviolet photobiology: its early roots and insights into DNA repair. DNA Repair (Amst). 2002;1:977-9 pubmed
    ..Most remarkably, a discovery of DNA repair by the use of split doses of UV light was reported in 1919. Later commentaries will take us sequentially through the early years of DNA repair. ..
  3. Schindl A, Rosado Schlosser B, Trautinger F. [Reciprocity regulation in photobiology. An overview]. Hautarzt. 2001;52:779-85 pubmed
    ..To date few studies have addressed the validity of this rule in experimental and applied photobiology. Most of these data point to the fact that the rule of reciprocity is invalid or of limited validity for many ..
  4. Calzavara Pinton P, Venturini M, Sala R. Photodynamic therapy: update 2006. Part 1: Photochemistry and photobiology. J Eur Acad Dermatol Venereol. 2007;21:293-302 pubmed
    ..The photobiology and photoimmunology of the haematoporphyrin (Hp) derivative and its purified, lyophilized and concentrated form ..
  5. Partch C, Sancar A. Photochemistry and photobiology of cryptochrome blue-light photopigments: the search for a photocycle. Photochem Photobiol. 2005;81:1291-304 pubmed
    ..In particular, the role of the unique C-terminal domain in cryptochrome phototransduction is discussed. ..
  6. Hockberger P. A history of ultraviolet photobiology for humans, animals and microorganisms. Photochem Photobiol. 2002;76:561-79 pubmed
  7. Corrochano L, Garre V. Photobiology in the Zygomycota: multiple photoreceptor genes for complex responses to light. Fungal Genet Biol. 2010;47:893-9 pubmed publisher
    ..Some of these genes are required for fungal photoresponses, but the function of many of them remains unknown. The presence of multiple wc-1 genes confirms previous suggestions of multiple blue-light photoreceptors in Phycomyces. ..
  8. Ogbonna J, Soejima T, Tanaka H. An integrated solar and artificial light system for internal illumination of photobioreactors. J Biotechnol. 1999;70:289-97 pubmed
    ..In this way, continuous light supply to the reactor is achieved by using solar light during sunny period, and artificial light at night and on cloudy days. ..
  9. Trautinger F. Heat shock proteins in the photobiology of human skin. J Photochem Photobiol B. 2001;63:70-7 pubmed
    ..Prerequisite for the utilization of this concept is the development of non-toxic heat shock inducers and their evaluation for clinical efficacy and safety. ..

More Information


  1. Kadekaro A, Kavanagh R, Wakamatsu K, Ito S, Pipitone M, Abdel Malek Z. Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round?. Pigment Cell Res. 2003;16:434-47 pubmed
  2. Boyden E, Zhang F, Bamberg E, Nagel G, Deisseroth K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci. 2005;8:1263-8 pubmed
    ..This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers. ..
  3. Carlozzi P. Dilution of solar radiation through "culture" lamination in photobioreactor rows facing south-north: a way to improve the efficiency of light utilization by cyanobacteria (Arthrospira platensis). Biotechnol Bioeng. 2003;81:305-15 pubmed
    ..1g (d.w.) MJ(-1)]. In TURP-10r, the high photic ratio (R(f) = 6), the high surface-to-volume ratio (S(ill)/V = 400 m(-1)) and the S-N facing of the rows (better than an E-W orientation) allowed for good results. ..
  4. Janssen M, Tramper J, Mur L, Wijffels R. Enclosed outdoor photobioreactors: light regime, photosynthetic efficiency, scale-up, and future prospects. Biotechnol Bioeng. 2003;81:193-210 pubmed
    ..Future designs from optical engineers should be used to collect, concentrate, and transport sunlight, followed by redistribution in a large-scale photobioreactor. ..
  5. Sliney D. Radiometric quantities and units used in photobiology and photochemistry: recommendations of the Commission Internationale de L'Eclairage (International Commission on Illumination). Photochem Photobiol. 2007;83:425-32 pubmed
    ..As photobiology and photochemistry both represent the fusion of several scientific disciplines, it is not surprising that the ..
  6. Carlozzi P, Sacchi A. Biomass production and studies on Rhodopseudomonas palustris grown in an outdoor, temperature controlled, underwater tubular photobioreactor. J Biotechnol. 2001;88:239-49 pubmed
    ..A reduced rate of protein synthesis continued even in the dark. PHB and carbohydrates, synthesized in excess during the day, were used as substrates for night protein synthesis...
  7. Carlozzi P, Buccioni A, Minieri S, Pushparaj B, Piccardi R, Ena A, et al. Production of bio-fuels (hydrogen and lipids) through a photofermentation process. Bioresour Technol. 2010;101:3115-20 pubmed publisher
    ..Biomasses stored at the end of each experimental set were analyzed in order to determine lipid content, which ranged from a minimum of 22 + or - 1% to a maximum of 39 + or - 2% of biomass dry weight. ..
  8. Gasparro F. Sunscreens, skin photobiology, and skin cancer: the need for UVA protection and evaluation of efficacy. Environ Health Perspect. 2000;108 Suppl 1:71-8 pubmed
    ..In this review, the basic aspects of sunscreens and skin photobiology are reviewed briefly...
  9. Setlow R. My early days in photobiology with Philip Hanawalt. Mutat Res. 2005;577:4-8 pubmed
    ..That communication was essential in elucidating some of the important steps in nucleotide excision repair-a field in which Phil is a pre-eminent scholar and investigator. ..
  10. Gibbs N, Tye J, Norval M. Recent advances in urocanic acid photochemistry, photobiology and photoimmunology. Photochem Photobiol Sci. 2008;7:655-67 pubmed publisher
    ..This review summarises the photochemical, photobiological and photoimmunological findings regarding UCA, published since 1998...
  11. Carlozzi P, Pinzani E. Growth characteristics of Arthrospira platensis cultured inside a new close-coil photobioreactor incorporating a mandrel to control culture temperature. Biotechnol Bioeng. 2005;90:675-84 pubmed
    ..The advantages of the airlift system may be due to the low concentration of oxygen built up inside Arthrospira culture and the lack of cell damage due to the pump system. Thus, oxygen and pump stress may have been avoided. ..
  12. Bethea D, Fullmer B, Syed S, Seltzer G, Tiano J, Rischko C, et al. Psoralen photobiology and photochemotherapy: 50 years of science and medicine. J Dermatol Sci. 1999;19:78-88 pubmed
    ..However, in recent years there has been a new found interest in the basic aspects of psoralen photobiology and molecular mechanistic events contributing to therapeutic responses as well as to the development of skin ..
  13. Tedesco A, Martinez L, Gonzalez S. Photochemistry and photobiology of actinic erythema: defensive and reparative cutaneous mechanisms. Braz J Med Biol Res. 1997;30:561-75 pubmed
    ..With the advance of our knowledge in cutaneous photochemistry, photobiology and photomedicine over the past four decades, the terrestrial solar radiation has become a concern of ..
  14. Cornet J, Favier L, Dussap C. Modeling stability of photoheterotrophic continuous cultures in photobioreactors. Biotechnol Prog. 2003;19:1216-27 pubmed
    ..The robustness of the proposed model allows the engineering operating domain of the photobioreactor function to be set and offers a promising tool for the design and control of such photoheterotrophic processes. ..
  15. Hawes I, Lund Hansen L, Sorrell B, Nielsen M, Borzák R, Buss I. Photobiology of sea ice algae during initial spring growth in Kangerlussuaq, West Greenland: insights from imaging variable chlorophyll fluorescence of ice cores. Photosynth Res. 2012;112:103-15 pubmed publisher
    ..Variable chlorophyll fluorescence imaging offers a tool to determine how this situation may change over time and as brine channels and algal populations evolve. ..
  16. Hasegawa K, Masuda S, Ono T. Spectroscopic analysis of the dark relaxation process of a photocycle in a sensor of blue light using FAD (BLUF) protein Slr1694 of the cyanobacterium Synechocystis sp. PCC6803. Plant Cell Physiol. 2005;46:136-46 pubmed
    ..In contrast, a constrained light state formed under dehydrated conditions decayed much more slowly with no deuteration effects. A photocycle mechanism involving the proton transfer was proposed. ..
  17. Yang Y, Li Y, Li X, Guo X, Xiao X, Tang D, et al. Comparative proteomics analysis of light responses in cryptochrome1-304 and Columbia wild-type 4 of Arabidopsis thaliana. Acta Biochim Biophys Sin (Shanghai). 2008;40:27-37 pubmed
    ..This assessment was consistent with the known physiological responses of plants to light. ..
  18. Loriaux S, Avenson T, Welles J, McDermitt D, Eckles R, Riensche B, et al. Closing in on maximum yield of chlorophyll fluorescence using a single multiphase flash of sub-saturating intensity. Plant Cell Environ. 2013;36:1755-70 pubmed publisher
    ..The importance of using MPF methodology for interpreting chlorophyll fluorescence, in particular for integrating fluorescence and gas exchange measurements, is emphasized. ..
  19. Somers D, Kim W, Geng R. The F-box protein ZEITLUPE confers dosage-dependent control on the circadian clock, photomorphogenesis, and flowering time. Plant Cell. 2004;16:769-82 pubmed
    ..We also demonstrate that ZTL-dependent delay of flowering is mediated through decreases in CONSTANS and FLOWERING LOCUS T message levels, thus directly linking proteasome-dependent proteolysis to flowering. ..
  20. Hanlon E, Itzkan I, Dasari R, Feld M, Ferrante R, McKee A, et al. Near-infrared fluorescence spectroscopy detects Alzheimer's disease in vitro. Photochem Photobiol. 1999;70:236-42 pubmed
    ..This is the first step toward a clinical tool that has the potential to be applied to the noninvasive diagnosis of AD in living patients. ..
  21. Kolossov V, Rebeiz C. Chloroplast biogenesis 88. Protochlorophyllide b occurs in green but not in etiolated plants. J Biol Chem. 2003;278:49675-8 pubmed
    ..It is concluded that the proposed occurrence of a light-harvesting POR-Pchlide-a,b complex in etiolated plant tissues is untenable, and its ensuing consequences and implications, for the greening process, are irrelevant. ..
  22. Liu M, Asanuma H, Komiyama M. Azobenzene-tethered T7 promoter for efficient photoregulation of transcription. J Am Chem Soc. 2006;128:1009-15 pubmed
    ..The cooperation of two azobenzenes at loop-binding and unwinding regions would contribute to the clear-cut photoregulation of transcription. ..
  23. Raviv M, Antignus Y. UV radiation effects on pathogens and insect pests of greenhouse-grown crops. Photochem Photobiol. 2004;79:219-26 pubmed
    ..Examples of these management strategies are described in this article. ..
  24. Jang I, Yang S, Yang J, Chua N. Independent and interdependent functions of LAF1 and HFR1 in phytochrome A signaling. Genes Dev. 2007;21:2100-11 pubmed
  25. Mitchell D, Nairn R, Johnston D, Byrom M, Kazianis S, Walter R. Decreased levels of (6-4) photoproduct excision repair in hybrid fish of the genus Xiphophorus. Photochem Photobiol. 2004;79:447-52 pubmed
    ..These data demonstrate reduced function in multienzyme hybrid systems and provide molecular support for potential reduced fitness in hybrid fish under conditions of environmental stress. ..
  26. Hall D, Fernández F, Guerrero E, Rao K, Grima E. Outdoor helical tubular photobioreactors for microalgal production: modeling of fluid-dynamics and mass transfer and assessment of biomass productivity. Biotechnol Bioeng. 2003;82:62-73 pubmed
    ..In this way the efficiency of the cells increased and higher biomass concentrations and productivities were reached for the same solar irradiance. ..
  27. Hirose E, Fukuda T. Vertical transmission of photosymbionts in the colonial ascidian Didemnum molle: the larval tunic prevents symbionts from attaching to the anterior part of larvae. Zoolog Sci. 2006;23:669-74 pubmed
    ..The thin larval tunic layer is probably not adhesive and protects the anterior half of the trunk from interference by Prochloron cells with sensory receptors and adhesive organs...
  28. Sakurai H, Masukawa H, Kitashima M, Inoue K. A feasibility study of large-scale photobiological hydrogen production utilizing mariculture-raised cyanobacteria. Adv Exp Med Biol. 2010;675:291-303 pubmed publisher
    ..Assuming that solar energy is converted to H(2) at 1.2% efficiency, the future cost of H(2) can be estimated to be about 11 (pipelines) and 26.4 (compression and marine transportation) cents kWh(-1), respectively. ..
  29. Su G, Wei Y, Wang H. NADH fluorescence as a photobiological metric in 5-aminolevlinic acid (ALA)-photodynamic therapy. Opt Express. 2011;19:21145-54 pubmed publisher
    ..This feature will be unique in the use of optimizing apoptosis-favored treatments such as metronomic PDT. ..
  30. Van Gelder R, Sancar A. Cryptochromes and inner retinal non-visual irradiance detection. Novartis Found Symp. 2003;253:31-42; discussion 42-55, 102-9, 281-4 pubmed
    ..These findings suggest a model where either classical photopigments or inner retinal photopigments are sufficient for non-visual irradiance detection. ..
  31. Aloisi G, Barbafina A, Canton M, Dall Acqua F, Elisei F, Facciolo L, et al. Photophysical and photobiological behavior of antimalarial drugs in aqueous solutions. Photochem Photobiol. 2004;79:248-58 pubmed
    ..The combined approaches were proven to be useful for understanding the mechanism of phototoxicity induced by the antimalarial drugs. ..
  32. Pierik R, Whitelam G, Voesenek L, de Kroon H, Visser E. Canopy studies on ethylene-insensitive tobacco identify ethylene as a novel element in blue light and plant-plant signalling. Plant J. 2004;38:310-9 pubmed
    ..Together, these data show that neighbour detection signals other than the R:FR ratio are more important than previously anticipated and argue for a particularly important role for ethylene in determining plant responses to neighbours. ..
  33. Volanti C, Matroule J, Piette J. Involvement of oxidative stress in NF-kappaB activation in endothelial cells treated by photodynamic therapy. Photochem Photobiol. 2002;75:36-45 pubmed
  34. Phelps J. Dark therapy for bipolar disorder using amber lenses for blue light blockade. Med Hypotheses. 2008;70:224-9 pubmed
  35. Astner S, Anderson R. Skin phototypes 2003. J Invest Dermatol. 2004;122:xxx-xxxi pubmed
  36. Horio T, Miyauchi Hashimoto H, Kuwamoto K, Yamazaki F, Okamoto H. Photobiological information obtained from XPA gene-deficient mice. Photochem Photobiol. 2007;83:218-24 pubmed
    ..model mouse is a useful experimental animal not only to investigate the mechanisms of photosensitivity in XP, but also to study physiological photobiology in humans, because photobiologic reactions are greatly intensified in this mouse.
  37. Fedorov A, Kosourov S, Ghirardi M, Seibert M. Continuous hydrogen photoproduction by Chlamydomonas reinhardtii: using a novel two-stage, sulfate-limited chemostat system. Appl Biochem Biotechnol. 2005;121-124:403-12 pubmed
    ..The dependence of the H2 production rate on sulfate concentration in the medium, dilution rates in the PhBRs, and incident light intensity is reported. ..
  38. Roll E. Bilirubin-induced cell death during continuous and intermittent phototherapy and in the dark. Acta Paediatr. 2005;94:1437-42 pubmed
    ..Continuous and intermittent light exposure caused the same degree of apoptotic cell death, while the cells underwent more necrotic death after intermittent exposure. Bilirubin was cytotoxic in the dark by both cell death mechanisms. ..
  39. Piazena H, Kelleher D. Effects of infrared-A irradiation on skin: discrepancies in published data highlight the need for an exact consideration of physical and photobiological laws and appropriate experimental settings. Photochem Photobiol. 2010;86:687-705 pubmed publisher
  40. Lamparter T, Marwan W. Spectroscopic detection of a phytochrome-like photoreceptor in the myxomycete Physarum polycephalum and the kinetic mechanism for the photocontrol of sporulation by Pfr. Photochem Photobiol. 2001;73:697-702 pubmed
    ..We propose a kinetic mechanism for the photocontrol of sporulation by photoconversion of Pfr, which may also hold for the high-irradiance response to FR in Arabidopsis and Cuscuta...
  41. Tomioka K, Miyasako Y, Umezaki Y. PDF as a coupling mediator between the light-entrainable and temperature-entrainable clocks in Drosophila melanogaster. Acta Biol Hung. 2008;59 Suppl:149-55 pubmed publisher
    ..These results support our hypothesis that the PDF-positive light entrainable cells regulate the phase of the temperature entrainable cells to be synchronized to their own phase using PDF as a coupling mediator. ..
  42. Danon A, Coll N, Apel K. Cryptochrome-1-dependent execution of programmed cell death induced by singlet oxygen in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2006;103:17036-41 pubmed
    ..The singlet oxygen-mediated and cryptochrome-dependent cell death response differs in several ways from PCD triggered by hydrogen peroxide/superoxide. ..
  43. Cogdell R, Isaacs N, Freer A, Howard T, Gardiner A, Prince S, et al. The structural basis of light-harvesting in purple bacteria. FEBS Lett. 2003;555:35-9 pubmed
    ..0 A [Papiz et al., J. Mol. Biol. 326 (2003) 1523-1538]. We show how this structure has helped to reveal the details of the various excitation energy transfer events in which it is involved. ..
  44. Parisi A, Green A, Kimlin M. Diffuse solar UV radiation and implications for preventing human eye damage. Photochem Photobiol. 2001;73:135-9 pubmed
    ..The average percentage diffuse UVB over all the measurements in the tree shade for the morning, noon and afternoon was 62, 58 and 71%, respectively, and the average percentage diffuse UVA was 52, 51 and 59%, respectively. ..
  45. Bosma R, Miazek K, Willemsen S, Vermuë M, Wijffels R. Growth inhibition of Monodus subterraneus by free fatty acids. Biotechnol Bioeng. 2008;101:1108-14 pubmed publisher
    ..Growth was inhibited for 50% already at concentrations of 0.4 microM 16:0 and 3 microM 18:1omega9, respectively. These fatty acids probably cause the growth inhibition in high cell density cultures of M. subterraneus. ..
  46. Tóth Boconádi R, Keszthelyi L, Stoeckenius W. Photoexcitation of the O-intermediate in bacteriorhodopsin mutant L93A. Biophys J. 2003;84:3857-63 pubmed
    ..Both the OI- and OII-decays are apparently strongly inhibited in the mutant...
  47. Jiang H, Granville D, North J, Richter A, Hunt D. Selective action of the photosensitizer QLT0074 on activated human T lymphocytes. Photochem Photobiol. 2002;76:224-31 pubmed
    ..This work shows that PDT with QLT0074 exerts selective, dose-related effects on T cells in vitro. ..
  48. Viviani V, Hastings J, Wilson T. Two bioluminescent diptera: the North American Orfelia fultoni and the Australian Arachnocampa flava. Similar niche, different bioluminescence systems. Photochem Photobiol. 2002;75:22-7 pubmed
    ..The present findings indicate that the bioluminescence of O. fultoni constitutes a novel bioluminescent system unrelated to that of Arachnocampa. ..
  49. Hirose E, Hirose M, Neilan B. Localization of symbiotic cyanobacteria in the colonial ascidian Trididemnum miniatum (Didemnidae, Ascidiacea). Zoolog Sci. 2006;23:435-42 pubmed
    ..Thin layer chromatography showed that the symbionts possessed both chlorophyll a and b, while a 16S rRNA gene phylogeny supported the identification of the photosymbiont of T. miniatum as Prochloron sp...
  50. Hamblin M, O Donnell D, Murthy N, Contag C, Hasan T. Rapid control of wound infections by targeted photodynamic therapy monitored by in vivo bioluminescence imaging. Photochem Photobiol. 2002;75:51-7 pubmed
    ..Our study points to the possible use of this methodology in the rapid control of wounds and other localized infections. ..
  51. Mertiri T, Chen M, Holland T, Basu A. Optical microplates for photonic high throughput screening of algal photosynthesis and biofuel production. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:482-5 pubmed publisher
    ..This instrument opens up novel high throughput protocols for photobiology and the growing field of phenomics.
  52. Bittl R, Weber S. Transient radical pairs studied by time-resolved EPR. Biochim Biophys Acta. 2005;1707:117-26 pubmed
    ..Both EPR methods have recently been applied to a variety of light-induced RPs in photobiology. This review summarizes the results obtained from such studies in the fields of plant and bacterial ..
  53. Soncin M, Busetti A, Fusi F, Jori G, Rodgers M. Irradiation of amelanotic melanoma cells with 532 nm high peak power pulsed laser radiation in the presence of the photothermal sensitizer Cu(II)-hematoporphyrin: a new approach to cell photoinactivation. Photochem Photobiol. 1999;69:708-12 pubmed
    ..The porphyrin-cell incubation time prior to irradiation had a major influence on cell survival, suggesting that the nature of the CuHp microenvironment can control the efficiency of photothermal sensitization. ..