developmental biology


Summary: The field of biology which deals with the process of the growth and differentiation of an organism.

Top Publications

  1. Rossant J. The impact of developmental biology on pluripotent stem cell research: successes and challenges. Dev Cell. 2011;21:20-3 pubmed publisher
    ..However, details of developmental pathways differ even across mammalian species. Full realization of the potential of stem cells will require more direct studies of human or primate developmental biology.
  2. Kieserman E, Lee C, Gray R, Park T, Wallingford J. High-magnification in vivo imaging of Xenopus embryos for cell and developmental biology. Cold Spring Harb Protoc. 2010;2010:pdb.prot5427 pubmed publisher
    ..This protocol describes methods for labeling and high-magnification time-lapse imaging of cell biological and developmental processes in Xenopus embryos by confocal microscopy. ..
  3. Tauber A. Reframing developmental biology and building evolutionary theory's new synthesis. Perspect Biol Med. 2010;53:257-70 pubmed publisher
    Gilbert and Epel present a new approach to developmental biology: embryogenesis must be understood within the full context of the organism's environment...
  4. Prigge M, Bezanilla M. Evolutionary crossroads in developmental biology: Physcomitrella patens. Development. 2010;137:3535-43 pubmed publisher
    ..patens has spurred a flurry of elegant reverse genetic studies in this plant model that address a variety of key questions in plant developmental biology.
  5. Federico S, Brennan R, Dyer M. Childhood cancer and developmental biology a crucial partnership. Curr Top Dev Biol. 2011;94:1-13 pubmed publisher
    For many years, there were relatively few research efforts that bridged the fields of developmental biology and cancer genetics. However, in the past decade, we have witnessed a dramatic shift and now these two fields are intertwined...
  6. Technau U, Steele R. Evolutionary crossroads in developmental biology: Cnidaria. Development. 2011;138:1447-58 pubmed publisher
  7. McClay D. Evolutionary crossroads in developmental biology: sea urchins. Development. 2011;138:2639-48 pubmed publisher
  8. Szabo R, Bugge T. Membrane-anchored serine proteases in vertebrate cell and developmental biology. Annu Rev Cell Dev Biol. 2011;27:213-35 pubmed publisher
    ..Here the cellular and developmental biology of this fascinating new group of proteases is reviewed...
  9. Weber M, Huisken J. Light sheet microscopy for real-time developmental biology. Curr Opin Genet Dev. 2011;21:566-72 pubmed publisher
    ..a few short years, light sheet microscopy has contributed substantially to the emerging field of real-time developmental biology. Low photo-toxicity and high-speed multiview acquisition have made selective plane illumination microscopy ..

More Information


  1. Bertrand S, Escriva H. Evolutionary crossroads in developmental biology: amphioxus. Development. 2011;138:4819-30 pubmed publisher
    ..We also summarize the major findings made using amphioxus that have informed us about the evolution of vertebrate traits...
  2. Setty Y. Multi-scale computational modeling of developmental biology. Bioinformatics. 2012;28:2022-8 pubmed publisher
    ..The source code of the model of the synthetic developmental system can be found in Supplementary data are available at Bioinformatics online. ..
  3. Matsumoto Y, Crews D. Molecular mechanisms of temperature-dependent sex determination in the context of ecological developmental biology. Mol Cell Endocrinol. 2012;354:103-10 pubmed publisher
    ..Here, we will discuss if the regulation of FoxL2 and Dmrt1 expression by environment is mediated through epigenetic mechanisms during development in species with TSD. ..
  4. Takagi C, Sakamaki K, Morita H, Hara Y, Suzuki M, Kinoshita N, et al. Transgenic Xenopus laevis for live imaging in cell and developmental biology. Dev Growth Differ. 2013;55:422-33 pubmed publisher
    ..protein (GFP) or red fluorescent protein (RFP), is an extremely important research tool in cell and developmental biology. Transgenic organisms constructed with fluorescent labels for cell membranes, subcellular organelles, and ..
  5. Zhu Z, Huangfu D. Human pluripotent stem cells: an emerging model in developmental biology. Development. 2013;140:705-17 pubmed publisher
    b>Developmental biology has long benefited from studies of classic model organisms...
  6. Davies S, Di Girolamo N. Corneal stem cells and their origins: significance in developmental biology. Stem Cells Dev. 2010;19:1651-62 pubmed publisher
  7. Iyer Pascuzzi A, Benfey P. Fluorescence-activated cell sorting in plant developmental biology. Methods Mol Biol. 2010;655:313-9 pubmed publisher
    ..specific cells of interest, and the information gained from this approach has been integral to plant developmental biology. The Benfey lab has developed this method to examine gene expression profiles of different cell types in ..
  8. Olsson L, Levit G, Hossfeld U. Evolutionary developmental biology: its concepts and history with a focus on Russian and German contributions. Naturwissenschaften. 2010;97:951-69 pubmed publisher
    ..Recently, developmental biology has been infused by evolutionary concepts and perspectives, and a new field of research--evolutionary ..
  9. Davidson L, Baum B. Making waves: the rise and fall and rise of quantitative developmental biology. Development. 2012;139:3065-9 pubmed publisher
    The tenth annual RIKEN Center for Developmental Biology symposium 'Quantitative Developmental Biology' held in March 2012 covered a range of topics from coat colour patterning to the mechanics of morphogenesis...
  10. Skinner M. Role of epigenetics in developmental biology and transgenerational inheritance. Birth Defects Res C Embryo Today. 2011;93:51-5 pubmed publisher
    The molecular mechanisms involved in developmental biology and cellular differentiation have traditionally been considered to be primarily genetic...
  11. Shimeld S, Donoghue P. Evolutionary crossroads in developmental biology: cyclostomes (lamprey and hagfish). Development. 2012;139:2091-9 pubmed publisher
    ..We then discuss how studies of cyclostomes have provided important insight into the evolution of fins, jaws, skeleton and neural crest. ..
  12. Meunier R. Stages in the development of a model organism as a platform for mechanistic models in developmental biology: Zebrafish, 1970-2000. Stud Hist Philos Biol Biomed Sci. 2012;43:522-31 pubmed publisher
    ..I will use the history of zebrafish biology to show how model organism systems, from around 1970 on, were developed to construct material models of molecular mechanisms explaining developmental or physiological processes. ..
  13. Spencer T, Dunlap K, Filant J. Comparative developmental biology of the uterus: insights into mechanisms and developmental disruption. Mol Cell Endocrinol. 2012;354:34-53 pubmed publisher
    ..Clear conservation of some factors and pathways are observed between species; therefore, comparative biology is useful to identify candidate genes and pathways underlying congenital abnormalities in humans...
  14. Martín Durán J, Monjo F, Romero R. Planarian embryology in the era of comparative developmental biology. Int J Dev Biol. 2012;56:39-48 pubmed publisher
    During the last decade, the field of evolutionary developmental biology (evo-devo) has emerged as a major research discipline in modern biology and an essential approach to understanding evolutionary relationships in the animal kingdom...
  15. Röttinger E, Lowe C. Evolutionary crossroads in developmental biology: hemichordates. Development. 2012;139:2463-75 pubmed publisher
    ..In this Primer, we introduce representative hemichordate species with contrasting modes of development and summarize recent findings that are beginning to yield important insights into deuterostome developmental mechanisms. ..
  16. Hilbrant M, Damen W, McGregor A. Evolutionary crossroads in developmental biology: the spider Parasteatoda tepidariorum. Development. 2012;139:2655-62 pubmed publisher
  17. Schaap P. Evolutionary crossroads in developmental biology: Dictyostelium discoideum. Development. 2011;138:387-96 pubmed publisher
    ..In this Primer, I discuss the mechanisms that control multicellular development in Dictyostelium discoideum and reconstruct how some of these mechanisms evolved from a stress response in the unicellular ancestor. ..
  18. McNally M, Wahlin K, Canto Soler M. Endogenous expression of ASLV viral proteins in specific pathogen free chicken embryos: relevance for the developmental biology research field. BMC Dev Biol. 2010;10:106 pubmed publisher
    ..These observations have critical implications for the developmental biology research field, since they strongly suggest that the current standard methodology used in experimental ..
  19. Lippincott Schwartz J. Bridging structure and process in developmental biology through new imaging technologies. Dev Cell. 2011;21:5-10 pubmed publisher
    Many unexpected discoveries in developmental biology have depended on advancement of imaging technologies to visualize developmental processes as they unfold across multiple spatial and temporal scales...
  20. Hiatt A, Davis G, Trujillo C, Terry M, French D, Price R, et al. Getting to evo-devo: concepts and challenges for students learning evolutionary developmental biology. CBE Life Sci Educ. 2013;12:494-508 pubmed publisher
    ..concepts (CCs) within a framework that integrates supporting concepts (SCs) from both evolutionary and developmental biology can improve evo-devo instruction...
  21. Anglani F, Mezzabotta F, Ceol M, Cristofaro R, Del Prete D, D Angelo A. The regenerative potential of the kidney: what can we learn from developmental biology?. Stem Cell Rev. 2010;6:650-7 pubmed publisher
    ..b>Developmental biology suggests that this might be particularly true of the kidney and that the papilla might represent the ..
  22. Levin M. Molecular bioelectricity in developmental biology: new tools and recent discoveries: control of cell behavior and pattern formation by transmembrane potential gradients. Bioessays. 2012;34:205-17 pubmed publisher
    ..This will enable fundamental advances in basic understanding of growth and form, as well as transformative biomedical applications in regenerative medicine. ..
  23. Bode H. Axial patterning in hydra. Cold Spring Harb Perspect Biol. 2009;1:a000463 pubmed publisher
    ..Little is known about the molecular basis of the two gradients. In contrast, the canonical Wnt pathway plays a central role in setting up and maintaining the head organizer. ..
  24. Huisken J, Stainier D. Selective plane illumination microscopy techniques in developmental biology. Development. 2009;136:1963-75 pubmed publisher
  25. Ereskovsky A, Borchiellini C, Gazave E, Ivanisevic J, Lapébie P, Perez T, et al. The Homoscleromorph sponge Oscarella lobularis, a promising sponge model in evolutionary and developmental biology: model sponge Oscarella lobularis. Bioessays. 2009;31:89-97 pubmed publisher
    ..In this review, we explore the specific features that make O. lobularis a promising homoscleromorph sponge model for evolutionary and developmental researches. ..
  26. Atallah J, Larsen E. Genotype-phenotype mapping developmental biology confronts the toolkit paradox. Int Rev Cell Mol Biol. 2009;278:119-48 pubmed publisher
  27. Mozdziak P, Petitte J. Status of transgenic chicken models for developmental biology. Dev Dyn. 2004;229:414-21 pubmed
    ..A more powerful tool for developmental biology research than the quail:chick chimera system would be to have lines of transgenic chickens expressing ..
  28. Bentley S, Brown S, Murphy L, Harris D, Quail M, Parkhill J, et al. SCP1, a 356,023 bp linear plasmid adapted to the ecology and developmental biology of its host, Streptomyces coelicolor A3(2). Mol Microbiol. 2004;51:1615-28 pubmed
    ..This may be related to atypical features of its end sequences. ..
  29. Irish V, Benfey P. Beyond Arabidopsis. Translational biology meets evolutionary developmental biology. Plant Physiol. 2004;135:611-4 pubmed
    ..pathways and determining how they are modified during evolution is the focus of the field of evolutionary developmental biology, or evo-devo...
  30. Stern C. The chick embryo--past, present and future as a model system in developmental biology. Mech Dev. 2004;121:1011-3 pubmed
  31. Serb J, Oakley T. Hierarchical phylogenetics as a quantitative analytical framework for evolutionary developmental biology. Bioessays. 2005;27:1158-66 pubmed
    Phylogenetics has inherent utility in evolutionary developmental biology (EDB) as it is an established methodology for estimating evolutionary relationships and for making comparisons between levels of biological organization...
  32. Chimge N, Ruddle F, Bayarsaihan D. Laser-assisted microdissection (LAM) in developmental biology. J Exp Zool B Mol Dev Evol. 2007;308:113-8 pubmed
    ..This review gives an overview of the LAM technology and its application in developmental biology.
  33. Perrimon N, Mathey Prevot B. Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Genetics. 2007;175:7-16 pubmed
    ..we provide examples of the various applications of the method to problems in signal transduction and cell and developmental biology. Finally, we discuss emerging technological advances that will extend RNAi-based screening methods.
  34. Ingber D, Levin M. What lies at the interface of regenerative medicine and developmental biology?. Development. 2007;134:2541-7 pubmed
    At a recent Keystone Symposium on 'Developmental Biology and Tissue Engineering', new findings in areas ranging from stem cell differentiation, embryonic pattern formation and organ regeneration to engineered cell microenvironments, ..
  35. Bard J. Systems developmental biology: the use of ontologies in annotating models and in identifying gene function within and across species. Mamm Genome. 2007;18:402-11 pubmed
    Systems developmental biology is an approach to the study of embryogenesis that attempts to analyze complex developmental processes through integrating the roles of their molecular, cellular, and tissue participants within a ..
  36. Raff R. Written in stone: fossils, genes and evo-devo. Nat Rev Genet. 2007;8:911-20 pubmed
    ..Finally, although fossils rarely yield data on developmental processes directly, informative examples occur of extraordinary preservation of soft body parts, embryos and genomic information. ..
  37. Canestro C, Yokoi H, Postlethwait J. Evolutionary developmental biology and genomics. Nat Rev Genet. 2007;8:932-42 pubmed can similar forms develop from different toolkits? Genomics bridges the gap between evolutionary and developmental biology, and can help answer these evo-devo questions in several ways...
  38. Gehring K, EASTMAN D. Information fluency for undergraduate biology majors: applications of inquiry-based learning in a developmental biology course. CBE Life Sci Educ. 2008;7:54-63 pubmed publisher enhance and study discipline-specific information fluency skills in an upper-level undergraduate Developmental Biology course...
  39. Oates A, Gorfinkiel N, Gonzalez Gaitan M, Heisenberg C. Quantitative approaches in developmental biology. Nat Rev Genet. 2009;10:517-30 pubmed publisher
  40. Muller G. Evo-devo: extending the evolutionary synthesis. Nat Rev Genet. 2007;8:943-9 pubmed
    Evolutionary developmental biology (evo-devo) explores the mechanistic relationships between the processes of individual development and phenotypic change during evolution...
  41. Minelli A. Phylo-evo-devo: combining phylogenetics with evolutionary developmental biology. BMC Biol. 2009;7:36 pubmed publisher
    ..Through this exemplary case, the paper demonstrates the value of the reciprocal illumination we can expect from the integration of a good phylogeny and a sound knowledge of the evolvability of developmental mechanisms. ..
  42. Sun C, Chu S, Chen S, Tsai T, Liu T, Lin C, et al. Higher harmonic generation microscopy for developmental biology. J Struct Biol. 2004;147:19-30 pubmed
  43. D Costa A, Shepherd I. Zebrafish development and genetics: introducing undergraduates to developmental biology and genetics in a large introductory laboratory class. Zebrafish. 2009;6:169-77 pubmed publisher
    We have taken advantage of the strengths of the zebrafish model system to introduce developmental biology and genetics to undergraduates in their second semester of the Introductory Biology course at Emory...
  44. Sommer R. The future of evo-devo: model systems and evolutionary theory. Nat Rev Genet. 2009;10:416-22 pubmed publisher
    There has been a recent trend in evolutionary developmental biology (evo-devo) towards using increasing numbers of model species...
  45. Callery E. There's more than one frog in the pond: a survey of the Amphibia and their contributions to developmental biology. Semin Cell Dev Biol. 2006;17:80-92 pubmed
    The study of developmental biology has benefited greatly from the insights gained using amphibians as experimental models...
  46. Irion S, Nostro M, Kattman S, Keller G. Directed differentiation of pluripotent stem cells: from developmental biology to therapeutic applications. Cold Spring Harb Symp Quant Biol. 2008;73:101-10 pubmed publisher
    ..Some of the most successful approaches in this area to date are those that have applied the principles of developmental biology to stem cell differentiation...
  47. Scholtz G. Homology and ontogeny: pattern and process in comparative developmental biology. Theory Biosci. 2005;124:121-43 pubmed
    ..These two approaches must not be con-flated. This distinction leads to the conclusion that there is no ontogenetic homology "criterion". ..
  48. Urushihara H. Developmental biology of the social amoeba: history, current knowledge and prospects. Dev Growth Differ. 2008;50 Suppl 1:S277-81 pubmed publisher
    ..Chemotaxis, cell differentiation, genome and transcriptome, and the ecological and evolutionary implications of development are discussed...
  49. Mattick J. A new paradigm for developmental biology. J Exp Biol. 2007;210:1526-47 pubmed
  50. Turnbull D, Mori S. MRI in mouse developmental biology. NMR Biomed. 2007;20:265-74 pubmed
    ..Comparisons are made with other imaging technologies, including optical and ultrasound imaging, discussing the potential strengths and weaknesses of MRI and identifying the future challenges for MRI in mouse developmental biology.
  51. Ingber D, Mow V, Butler D, Niklason L, Huard J, Mao J, et al. Tissue engineering and developmental biology: going biomimetic. Tissue Eng. 2006;12:3265-83 pubmed
    ..quot;Tissue Engineering--The Next Generation," which was devoted to the interactions between developmental biology and tissue engineering...
  52. Baker R, Schnell S, Maini P. Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies. Int J Dev Biol. 2009;53:783-94 pubmed publisher
    ..We outline mathematical models to describe each patterning mechanism, present the results of numerical simulations and discuss the validity of each model in relation to our example patterning processes. ..
  53. Gilbert S. The morphogenesis of evolutionary developmental biology. Int J Dev Biol. 2003;47:467-77 pubmed
    The early studies of evolutionary developmental biology (Evo-Devo) come from several sources...