sphenoid bone

Summary

Summary: An irregular unpaired bone situated at the SKULL BASE and wedged between the frontal, temporal, and occipital bones (FRONTAL BONE; TEMPORAL BONE; OCCIPITAL BONE). Sphenoid bone consists of a median body and three pairs of processes resembling a bat with spread wings. The body is hollowed out in its inferior to form two large cavities (SPHENOID SINUS).

Top Publications

  1. Jane J, Han J, Prevedello D, Jagannathan J, Dumont A, Laws E. Perspectives on endoscopic transsphenoidal surgery. Neurosurg Focus. 2005;19:E2 pubmed
    ..The authors describe their current endoscopic technique and elucidate the advantages and disadvantages of the pure endoscopic adenomectomy compared with the standard microscopic approach...
  2. Baumann F, Schmid C, Bernays R. Intraoperative magnetic resonance imaging-guided transsphenoidal surgery for giant pituitary adenomas. Neurosurg Rev. 2010;33:83-90 pubmed publisher
    ..More radical removal of adenomas in a single surgical session combined with low complication rates are accomplished. This may add to a favorable clinical and endocrinological outcome in GPAs...
  3. Conrad J, Philipps M, Oertel J. High-definition imaging in endoscopic transsphenoidal pituitary surgery. Am J Rhinol Allergy. 2011;25:e13-7 pubmed publisher
    ..The purpose of this study was to compare the image quality of a standard-definition (SD) camera with a new HD camera...
  4. Gondim J, Almeida J, Albuquerque L, Schops M, Gomes E, Ferraz T, et al. Endoscopic endonasal approach for pituitary adenoma: surgical complications in 301 patients. Pituitary. 2011;14:174-83 pubmed publisher
    ..Successful endoscopic pituitary surgery requires extensive training in the use of an endoscope and careful planning of the surgery. Additional improvement can be expected with greater experience and new technical developments...
  5. Shinohara A, de Souza Melo C, Silveira E, Lauris J, Andreo J, de Castro Rodrigues A. Incidence, morphology and morphometry of the foramen of Vesalius: complementary study for a safer planning and execution of the trigeminal rhizotomy technique. Surg Radiol Anat. 2010;32:159-64 pubmed publisher
    The foramen of Vesalius (FV) is located in the greater wing of the sphenoid bone between the foramen ovale (FO) and the foramen rotundum in an intracranial view...
  6. Koh Y, Yoo H. Epithelioid haemangioendothelioma of the sphenoid bone. J Clin Neurosci. 2001;8 Suppl 1:63-6 pubmed
    The authors report a case of cranial EH occurred in the left sphenoid bone that was totally excised without transfusion. A 26-year-old woman presented with a 1-year history of progressing exophthalmos in the left eye...
  7. Honegger J, Ernemann U, Psaras T, Will B. Objective criteria for successful transsphenoidal removal of suprasellar nonfunctioning pituitary adenomas. A prospective study. Acta Neurochir (Wien). 2007;149:21-9; discussion 29 pubmed
  8. Kabil M, Eby J, Shahinian H. Fully endoscopic endonasal vs. transseptal transsphenoidal pituitary surgery. Minim Invasive Neurosurg. 2005;48:348-54 pubmed
    ..Our results conclude that the fully endoscopic endonasal technique is a safe and effective method for removal of pituitary adenomas providing more complete tumor removal and reducing complications...
  9. Ojha B, Husain M, Rastogi M, Chandra A, Chugh A, Husain N. Combined trans-sphenoidal and simultaneous trans-ventricular-endoscopic decompression of a giant pituitary adenoma: case report. Acta Neurochir (Wien). 2009;151:843-7; discussion 847 pubmed publisher
    ..This is the first report of the simultaneous combined use of trans-sphenoidal and trans-ventricular-endoscopic route for decompression of a giant pituitary adenoma...

More Information

Publications62

  1. Bozbuga M, Turan Suslu H. Aneurysmal bone cyst of the sphenoid bone extending into the ethmoid sinus, nasal cavity and orbita in a child. Turk Neurosurg. 2009;19:172-6 pubmed
    ..The patient did not receive postoperative radiotherapy. No recurrence was observed after 22 months. ABC should be considered in the differential diagnosis of bone neoplasms in this region...
  2. Aralasmak A, Aygun N, Westra W, Yousem D. Giant cell reparative granuloma of the sphenoid bone. AJNR Am J Neuroradiol. 2006;27:1675-7 pubmed
    We present 2 patients with giant cell reparative granuloma (GCRG) of the sphenoid bone. The first patient is an 8-year-old boy with involvement of the greater wing, and the second is a 53- year-old man with a lateral pterygoid plate mass...
  3. Reymond J, Charuta A, Wysocki J. The morphology and morphometry of the foramina of the greater wing of the human sphenoid bone. Folia Morphol (Warsz). 2005;64:188-93 pubmed
    The greater wing of the human sphenoid bone is pierced by several foramina, which contain, as a main element, the venous anastomoses between the interior of the skull and the extracranial veins...
  4. Roser F, Nakamura M, Jacobs C, Vorkapic P, Samii M. Sphenoid wing meningiomas with osseous involvement. Surg Neurol. 2005;64:37-43; discussion 43 pubmed
    ..Sufficient resection of these meningiomas requires extensive surgical exposure. We report on 82 patients with meningiomas infiltrating the sphenoid wing, analyzing radiological appearance and its influence on surgical management...
  5. MacFarlane M, Soule S, Hunt P. Intraosseous lipoma of the body of the sphenoid bone. J Clin Neurosci. 2005;12:105-8 pubmed
    A case of intraosseous lipoma arising from the body of the sphenoid bone with intrasellar and suprasellar components is reported...
  6. Couldwell W. Transsphenoidal and transcranial surgery for pituitary adenomas. J Neurooncol. 2004;69:237-56 pubmed
    ..More recently, stereotactic radiosurgery (SRS) has become an important adjuvant management technique in the management of difficult pituitary adenomas, especially with cavernous sinus invasion...
  7. Jacquemin C, Mullaney P, Bosley T. Abnormal development of the lesser wing of the sphenoid with microphthalmos and microcephaly. Neuroradiology. 2001;43:178-82 pubmed
    We report two patients with abnormal development of the lesser wing of the sphenoid bone, globe, optic nerve and cerebral hemisphere without stigmata of neurofibromatosis type 1...
  8. Kim Y, Sato K, Mitani H, Shimizu Y, Kikuchi M. Asymmetry of the sphenoid bone and its suitability as a reference for analyzing craniofacial asymmetry. Am J Orthod Dentofacial Orthop. 2003;124:656-62 pubmed
    The purposes of this study were to evaluate the asymmetry of the sphenoid bone and to determine its suitability as a reference for analyzing asymmetry of the skull...
  9. Catala M. [Embryology of the sphenoid bone]. J Neuroradiol. 2003;30:196-200 pubmed
    The sphenoid bone represents a complex structure in terms of anatomy and embryology. Indeed, it is formed by the fusion of different primordia whose embryonic origins are different...
  10. Fahlbusch R, Keller B, Ganslandt O, Kreutzer J, Nimsky C. Transsphenoidal surgery in acromegaly investigated by intraoperative high-field magnetic resonance imaging. Eur J Endocrinol. 2005;153:239-48 pubmed
    ..The aim of the study was to evaluate the effect of intraoperative high-field (1.5 Tesla) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of GH-secreting pituitary macroadenomas...
  11. Sharma A, Garg A, Mishra N, Gaikwad S, Sharma M, Gupta V, et al. Primary Ewing's sarcoma of the sphenoid bone with unusual imaging features: a case report. Clin Neurol Neurosurg. 2005;107:528-31 pubmed
    ..Primary Ewing's sarcoma of the skull is a very rare entity. We report a case of Ewing's sarcoma of the sphenoid bone in a 5-year-old boy...
  12. Ceylan S, Koc K, Anik I. Endoscopic endonasal transsphenoidal approach for pituitary adenomas invading the cavernous sinus. J Neurosurg. 2010;112:99-107 pubmed publisher
    ..In this report, the authors describe their experience with surgical access to the cavernous sinus via a fully transnasal endoscopic approach in 20 cases. Clinical and endocrinological follow-up are discussed...
  13. Musleh W, Sonabend A, Lesniak M. Role of craniotomy in the management of pituitary adenomas and sellar/parasellar tumors. Expert Rev Anticancer Ther. 2006;6 Suppl 9:S79-83 pubmed
    ..Overall, craniotomies will continue to play a role in the management of patients with sellar/parasellar tumors, although patient selection and careful preoperative evaluation are key elements in choosing the most appropriate approach...
  14. Jacquemin C, Bosley T, Liu D, Svedberg H, Buhaliqa A. Reassessment of sphenoid dysplasia associated with neurofibromatosis type 1. AJNR Am J Neuroradiol. 2002;23:644-8 pubmed
    Sphenoid dysplasia associated with neurofibromatosis type 1 is classically thought to be primarily related to abnormal development of the sphenoid bone. We investigated the possibility that these changes may be progressive.
  15. Charalampaki P, Reisch R, Ayad A, Conrad J, Welschehold S, Perneczky A, et al. Endoscopic endonasal pituitary surgery: surgical and outcome analysis of 50 cases. J Clin Neurosci. 2007;14:410-5 pubmed
    ..In this retrospective study, we analysed the surgical technique and outcome of 50 patients with pituitary lesions treated with an endoscopic endonasal trans-sphenoidal approach...
  16. Shimon I, Cohen Z, Ram Z, Hadani M. Transsphenoidal surgery for acromegaly: endocrinological follow-up of 98 patients. Neurosurgery. 2001;48:1239-43; discussion 1244-5 pubmed
    ..We analyzed our postoperative results in a large cohort of patients with acromegaly...
  17. Kaplan M, Erol F, Ozveren M, Topsakal C, Sam B, Tekdemir I. Review of complications due to foramen ovale puncture. J Clin Neurosci. 2007;14:563-8 pubmed
    ..Thermocoagulation of the lateral wall of the cavernous sinus may damage the cranial nerves by heat, giving rise to pareses...
  18. Zorlu F, Selek U, Soylemezoglu F, Oge K. Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. J Neurooncol. 2006;76:149-52 pubmed
    We present a case report of a giant cell tumor located in the skull base orginating from clivus and sphenoid bone treated by surgery and external beam radiotherapy (EBRT).
  19. Greenfield J, Leng L, Chaudhry U, Brown S, Anand V, Souweidane M, et al. Combined simultaneous endoscopic transsphenoidal and endoscopic transventricular resection of a giant pituitary macroadenoma. Minim Invasive Neurosurg. 2008;51:306-9 pubmed publisher
    ..We describe the successful implementation of a minimal access endoscopic combined extended transsphenoidal and transventricular approach that avoids craniotomy and brain retraction...
  20. Wichers Rother M, Hoven S, Kristof R, Bliesener N, Stoffel Wagner B. Non-functioning pituitary adenomas: endocrinological and clinical outcome after transsphenoidal and transcranial surgery. Exp Clin Endocrinol Diabetes. 2004;112:323-7 pubmed
    ..To study improvement of anterior pituitary function after transsphenoidal and transcranial surgery of non-functioning (NF) pituitary macro- and microadenomas...
  21. Goel A, Nadkarni T, Muzumdar D, Desai K, Phalke U, Sharma P. Giant pituitary tumors: a study based on surgical treatment of 118 cases. Surg Neurol. 2004;61:436-45; discussion 445-6 pubmed
    ..The aim of the study is to analyze the nature, extensions, and dural relationships of hormonally inactive giant pituitary tumors. The relevance of the anatomic relationships to surgery is analyzed...
  22. Suzuki R, Asai J, Nagashima G, Itokawa H, Chang C, Noda M, et al. Transcranial echo-guided transsphenoidal surgical approach for the removal of large macroadenomas. J Neurosurg. 2004;100:68-72 pubmed
    ..To overcome these disadvantages, the authors have developed transcranial echo-guided transsphenoidal surgery...
  23. Liu J, Das K, Weiss M, Laws E, Couldwell W. The history and evolution of transsphenoidal surgery. J Neurosurg. 2001;95:1083-96 pubmed
    ..The evolution of the transsphenoidal approaches and their current applications and modifications are discussed...
  24. Ogiwara H, Morota N. Surgical treatment of transsphenoidal encephaloceles: transpalatal versus combined transpalatal and transcranial approach. J Neurosurg Pediatr. 2013;11:505-10 pubmed publisher
    ..anomaly with herniation of neural elements including pituitary gland or optic apparatus, through a defect of sphenoid bone. To prevent obstructive dyspnea, endocrine dysfunction, or visual disturbance, surgical correction is usually ..
  25. Patel S, Christiano L, Eloy J, Liu J. Delayed postoperative pituitary apoplexy after endoscopic transsphenoidal resection of a giant pituitary macroadenoma. J Clin Neurosci. 2012;19:1296-8 pubmed publisher
    ..Early detection and emergent endoscopic transsphenoidal exploration resulted in gross total removal of the residual tumor, decompression of the optic chiasm, and a favorable neurologic outcome...
  26. Kim E. Symptomatic Rathke cleft cyst: clinical features and surgical outcomes. World Neurosurg. 2012;78:527-34 pubmed publisher
    ..To depict the clinical, operative, and histological features of Rathke cleft cysts (RCCs) in consideration of therapeutic results and recurrence rates...
  27. Lee H, Lee Y, Ha S, Park M, Baek S. Measurement of width and distance of the posterior border of the deep lateral orbital wall using computed tomography. J Craniomaxillofac Surg. 2011;39:606-9 pubmed publisher
    ..We aimed to understand the anatomic localization and appearance of the lateral orbital wall by measuring the width and distance of the lateral wall on computed tomography (CT)...
  28. Park I, Lee S, Chun Y. A congruous superior quadrantanopsia following a junctional scotoma induced by asperogillosis. Korean J Ophthalmol. 2011;25:294-7 pubmed publisher
    ..Furthermore, damage to the distal optic nerve adjacent to the proximal optic chiasm can induce unusual congruous superior quadrantanopsia...
  29. Nunes C, Prevedello D, Carrau R, da Fonseca C, Landeiro J. Morphometric analysis of the medial opticocarotid recess and its anatomical relations relevant to the transsphenoidal endoscopic endonasal approaches. Acta Neurochir (Wien). 2016;158:319-24 pubmed publisher
    ..The MOCR may be used as a reference point for precise location of structures during EEA. Objective measurements may be especially useful in cases with distorted sphenoid bone anatomy.
  30. Goudakos J, Markou K, Georgalas C. Endoscopic versus microscopic trans-sphenoidal pituitary surgery: a systematic review and meta-analysis. Clin Otolaryngol. 2011;36:212-20 pubmed publisher
    ..Endoscopic trans-sphenoidal surgery has been increasingly replacing microscopic surgery as the state of the art trans-sphenoidal approach...
  31. Powell M, Grossman A. Quality indicators in pituitary surgery: a need for reliable and valid assessments. What should be measured?. Clin Endocrinol (Oxf). 2016;84:485-8 pubmed publisher
    ..There are, potentially, plenty of data out there. Given this background, how best should we measure quality in this important area of clinical practice?..
  32. Wagenmakers M, Netea Maier R, van Lindert E, Pieters G, Grotenhuis A, Hermus A. Results of endoscopic transsphenoidal pituitary surgery in 40 patients with a growth hormone-secreting macroadenoma. Acta Neurochir (Wien). 2011;153:1391-9 pubmed publisher
    ..However, no large series reporting on its results have yet been published. We evaluated the outcome of endoscopic TS in 40 patients with a growth hormone (GH)-secreting macroadenoma treated in our hospital between 1998 and 2007...
  33. Ozcan T, Yilmazlar S, Aker S, Korfali E. Surgical limits in transnasal approach to opticocarotid region and planum sphenoidale: an anatomic cadaveric study. World Neurosurg. 2010;73:326-33 pubmed publisher
    ..The significance of medial and lateral opticocarotid recesses and the planum sphenoidale region in skull base pathologies for the transsphenoidal-transplanum approach were evaluated...
  34. Icke C, Ozer E, Arda N. Microanatomical characteristics of the petrosphenoidal ligament of Gruber. Turk Neurosurg. 2010;20:323-7 pubmed publisher
    ..Details of its anatomy are conflicting in the few studies that exist in the literature. We performed this study to describe in detail the microanatomical characteristics of Gruber's ligament...
  35. Kinoshita Y, Tominaga A, Arita K, Sugiyama K, Hanaya R, Hama S, et al. Post-operative hyponatremia in patients with pituitary adenoma: post-operative management with a uniform treatment protocol. Endocr J. 2011;58:373-9 pubmed
    ..Special attention and recovery effort should be given to elder patients with marked serum Na level decline after surgery...
  36. Komatsu F, Komatsu M, Inoue T, Tschabitscher M. Endoscopic extradural anterior clinoidectomy via supraorbital keyhole: a cadaveric study. Neurosurgery. 2011;68:334-8; discussion 337-8 pubmed publisher
    ..Endoscopy is a widely accepted modality for neurosurgical strategies and is becoming more important in treating conditions involving the cranial base...
  37. Balasundram S, Cotrufo S, Liew C. Case series: non vascular considerations in trigeminal neuralgia. Clin Oral Investig. 2012;16:63-8 pubmed publisher
    ..This paper illustrates the clinical presentation of atypical trigeminal neuralgia and emphasises the value of diagnostic imaging in trigeminal neuralgia patient. Suggested algorithm for management of trigeminal neuralgia...
  38. Baccetti T, De Clerck H, Cevidanes L, Franchi L. Morphometric analysis of treatment effects of bone-anchored maxillary protraction in growing Class III patients. Eur J Orthod. 2011;33:121-5 pubmed publisher
    ..Deformations in the vertical dimension were not detected. The significant deformations were associated with significant differences in size in the group treated with the BAMP protocol...
  39. Bullock P, Dunaway D, McGurk L, Richards R. Integration of image guidance and rapid prototyping technology in craniofacial surgery. Int J Oral Maxillofac Surg. 2013;42:970-3 pubmed publisher
    ..Optimum reconstruction of large defects can be achieved with this technique. ..
  40. Lotfy M, Xu R, McGirt M, Sakr S, Ayoub B, Bydon A. Reconstruction of skull base defects in sphenoid wing dysplasia associated with neurofibromatosis I with titanium mesh. Clin Neurol Neurosurg. 2010;112:909-14 pubmed publisher
    ..The mesh was fixed by fine screws. Proptosis improved markedly post-operatively and resolved within a few weeks. Ocular pulsation subsided and remained quiescent with at least 1-year follow-up...
  41. Razak A, Horridge M, Connolly D, Warren D, Mirza S, Muraleedharan V, et al. Comparison of endoscopic and microscopic trans-sphenoidal pituitary surgery: early results in a single centre. Br J Neurosurg. 2013;27:40-3 pubmed publisher
    ..Pituitary surgery has seen a recent shift from a microscopic to an endoscopic trans-sphenoidal approach. We present our early experience with endoscopic surgery and compare the outcome with our recent microscopic experience...
  42. De Lacy P, Benjamin S, Dixon R, Stephens J, Redfern R, Price D. Is surgical intervention frequently required for medically managed macroprolactinomas? A study of spontaneous cerebrospinal fluid rhinorrhea. Surg Neurol. 2009;72:461-3; discussion 463 pubmed publisher
    ..The frequency of spontaneous CSF rhinorrhea in macroprolactinoma patients is poorly documented and was previously thought to be a very rare occurrence...
  43. Simmonds J, Scott A. Spontaneous CSF rhinorrhea from the trigeminal canal in an adolescent. Int J Pediatr Otorhinolaryngol. 2017;98:162-165 pubmed publisher
    ..We perform a literature review and describe a successful repair through an endoscopic transpterygoid approach, which allowed for resolution of symptoms with minimal postoperative morbidity. ..
  44. Kahilogullari G, Beton S, Al Beyati E, Kantarcioglu O, Bozkurt M, Kantarcioglu E, et al. Olfactory functions after transsphenoidal pituitary surgery: endoscopic versus microscopic approach. Laryngoscope. 2013;123:2112-9 pubmed publisher
    ..To our knowledge, no previous comparative studies on olfactory functions after transsphenoidal endoscopic and microscopic approaches have been performed...
  45. Sankhla S, Jayashankar N, Khan G. Surgical management of selected pituitary macroadenomas using extended endoscopic endonasal transsphenoidal approach: early experience. Neurol India. 2013;61:122-30 pubmed publisher
    ..Recently, the extended endoscopic endonasal approach (EEEA) has been utilized to excise this subgroup of pituitary adenomas successfully...
  46. Meel R, Thulkar S, Sharma M, Jagadesan P, Mohanti B, Sharma S, et al. Childhood osteosarcoma of greater wing of sphenoid: case report and review of literature. J Pediatr Hematol Oncol. 2012;34:e59-62 pubmed publisher
    ..Treatment of skull base osteosarcomas is difficult, as complete excision is often not possible. To the best of our knowledge, this is the first case of sphenoid wing osteosarcoma in childhood to be reported in literature...
  47. Izquierdo A, Mishima F, Carrard V, Farina M, Nojima M. Effects of induced precocious puberty on cranial growth in female Wistar rats. Eur J Orthod. 2012;34:133-40 pubmed publisher
    ..An appropriate model for studying bone growth associated with precocious puberty in Wistar female rats was not achieved using steroid hormone danazol, when evaluated at 30 day intervals...
  48. Lagravere M, Gordon J, Flores Mir C, Carey J, Heo G, Major P. Cranial base foramen location accuracy and reliability in cone-beam computerized tomography. Am J Orthod Dentofacial Orthop. 2011;139:e203-10 pubmed publisher
  49. Schipper J, Hoffmann T, Klenzner T, Wagenmann M. [Unsuccessful duraplasty technique or persisting/recanalized Sternberg's canal?]. Laryngorhinootologie. 2013;92:400-5 pubmed publisher
    ..The closure of this bony canal requires a modified surgical procedure such as sufficient padding of the bony canal and its sealing by a vascularized pedicle flap in contrast to the ordinary planar bony skull base defects...
  50. Dogan M, Kahraman A, Firat C, Kahraman B, Karatas E, Kizilay A. Intraosseous lipoma presenting as a sphenoid sinus mass. Eur Rev Med Pharmacol Sci. 2011;15:1339-42 pubmed
    ..In extremely rare conditions, it can appear in sphenoid bone, and only 2 cases have been described in literature until now...
  51. Hassani E, Karimi H, Hassani A. Inferior encephalocele: transpalatal repair using paired costal bone grafts with a 14-year follow-up. J Pediatr Surg. 2011;46:E9-13 pubmed publisher
    ..There was neither obliteration nor reduction in the size of the bony defect. There were no operative complications, and the shape of the nose improved. The patient and her parents were highly satisfied with the result...
  52. Pekcevik Y, Arslan I, Arslan Y. CT and MRI findings of the incidental intraosseous lipomatous lesions of the sphenoid bone. Head Neck. 2016;38:E41-4 pubmed publisher
    Intraosseous lipomatous lesions of the sphenoid bone and skull base are increasingly seen and cause a diagnostic challenge...
  53. Bassed R, Briggs C, Drummer O. Analysis of time of closure of the spheno-occipital synchondrosis using computed tomography. Forensic Sci Int. 2010;200:161-4 pubmed publisher
    ..After the age of 16 years there was no significant difference in progress of fusion between males and females. The study showed that this age marker is of limited value for age estimations around the age of 18 years in this population...