growth plate

Summary

Summary: The area between the EPIPHYSIS and the DIAPHYSIS within which bone growth occurs.

Top Publications

  1. Simsa Maziel S, Zaretsky J, Reich A, Koren Y, Shahar R, Monsonego Ornan E. IL-1RI participates in normal growth plate development and bone modeling. Am J Physiol Endocrinol Metab. 2013;305:E15-21 pubmed publisher
    ..Little is known about the effect of excess or absence of IL-1 signaling on the physiological development of the growth plate and bone...
  2. Takarada T, Kodama A, Hotta S, Mieda M, Shimba S, Hinoi E, et al. Clock genes influence gene expression in growth plate and endochondral ossification in mice. J Biol Chem. 2012;287:36081-95 pubmed publisher
    ..gene transactivation of the master regulator of chondrogenesis Indian hedgehog (IHH) in chondrocytes of the growth plate. Several clock genes were expressed with oscillatory rhythmicity in cultured chondrocytes and rib growth plate ..
  3. Leijten J, Emons J, Sticht C, Van Gool S, Decker E, Uitterlinden A, et al. Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis. Arthritis Rheum. 2012;64:3302-12 pubmed publisher
    ..is highly resistant to hypertrophic differentiation, in contrast to other hyaline cartilage subtypes, such as growth plate cartilage...
  4. Piszczatowski S. Material aspects of growth plate modelling using Carter's and Stokes's approaches. Acta Bioeng Biomech. 2011;13:3-14 pubmed
    b>Growth plate, named also as physis, is the anatomical structure responsible for the bone growth. Apart from numerous biological and biochemical factors, biomechanics has also strong influence on its functioning...
  5. Gillespie J, Ulici V, Dupuis H, Higgs A, DiMattia A, Patel S, et al. Deletion of glycogen synthase kinase-3? in cartilage results in up-regulation of glycogen synthase kinase-3? protein expression. Endocrinology. 2011;152:1755-66 pubmed publisher
    ..a mouse tibia organ culture system results in enhanced bone growth, accompanied by increased proliferation of growth plate chondrocytes and faster turnover of hypertrophic cartilage to bone...
  6. Bond S, Lau A, Penuela S, Sampaio A, Underhill T, Laird D, et al. Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. J Bone Miner Res. 2011;26:2911-22 pubmed publisher
    ..Taken together, our data suggests that Panx3 may serve an important role in bone development, and is a novel target for Runx2-dependent signaling...
  7. Groma G, Grskovic I, Schael S, Ehlen H, Wagener R, Fosang A, et al. Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state. Matrix Biol. 2011;30:275-80 pubmed publisher
    ..In this study, the processing and degradation of matrilin-4 during cartilage remodeling in the growth plate of the developing mouse long bones were studied in greater detail...
  8. Dy P, Wang W, Bhattaram P, Wang Q, Wang L, Ballock R, et al. Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell. 2012;22:597-609 pubmed publisher
    The transcription factor Sox9 is necessary for early chondrogenesis, but its subsequent roles in the cartilage growth plate, a highly specialized structure that drives skeletal growth and endochondral ossification, remain unclear...
  9. Plumb D, Ferrara L, Torbica T, Knowles L, Mironov A, Kadler K, et al. Collagen XXVII organises the pericellular matrix in the growth plate. PLoS ONE. 2011;6:e29422 pubmed publisher
    ..in the collagenous domain were phenotypically normal when heterozygote and displayed a mild disruption of growth plate architecture in the homozygous state...
  10. Ascenzi M, Blanco C, Drayer I, Kim H, Wilson R, Retting K, et al. Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization. J Theor Biol. 2011;285:147-55 pubmed publisher
    The research investigates the role of the immotile chondrocytic primary cilium in the growth plate. This study was motivated by (i) the recent evidence of the mechano-sensorial function of the primary cilium in kidney tubule epithelial ..

Detail Information

Publications62

  1. Simsa Maziel S, Zaretsky J, Reich A, Koren Y, Shahar R, Monsonego Ornan E. IL-1RI participates in normal growth plate development and bone modeling. Am J Physiol Endocrinol Metab. 2013;305:E15-21 pubmed publisher
    ..Little is known about the effect of excess or absence of IL-1 signaling on the physiological development of the growth plate and bone...
  2. Takarada T, Kodama A, Hotta S, Mieda M, Shimba S, Hinoi E, et al. Clock genes influence gene expression in growth plate and endochondral ossification in mice. J Biol Chem. 2012;287:36081-95 pubmed publisher
    ..gene transactivation of the master regulator of chondrogenesis Indian hedgehog (IHH) in chondrocytes of the growth plate. Several clock genes were expressed with oscillatory rhythmicity in cultured chondrocytes and rib growth plate ..
  3. Leijten J, Emons J, Sticht C, Van Gool S, Decker E, Uitterlinden A, et al. Gremlin 1, frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis. Arthritis Rheum. 2012;64:3302-12 pubmed publisher
    ..is highly resistant to hypertrophic differentiation, in contrast to other hyaline cartilage subtypes, such as growth plate cartilage...
  4. Piszczatowski S. Material aspects of growth plate modelling using Carter's and Stokes's approaches. Acta Bioeng Biomech. 2011;13:3-14 pubmed
    b>Growth plate, named also as physis, is the anatomical structure responsible for the bone growth. Apart from numerous biological and biochemical factors, biomechanics has also strong influence on its functioning...
  5. Gillespie J, Ulici V, Dupuis H, Higgs A, DiMattia A, Patel S, et al. Deletion of glycogen synthase kinase-3? in cartilage results in up-regulation of glycogen synthase kinase-3? protein expression. Endocrinology. 2011;152:1755-66 pubmed publisher
    ..a mouse tibia organ culture system results in enhanced bone growth, accompanied by increased proliferation of growth plate chondrocytes and faster turnover of hypertrophic cartilage to bone...
  6. Bond S, Lau A, Penuela S, Sampaio A, Underhill T, Laird D, et al. Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes. J Bone Miner Res. 2011;26:2911-22 pubmed publisher
    ..Taken together, our data suggests that Panx3 may serve an important role in bone development, and is a novel target for Runx2-dependent signaling...
  7. Groma G, Grskovic I, Schael S, Ehlen H, Wagener R, Fosang A, et al. Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state. Matrix Biol. 2011;30:275-80 pubmed publisher
    ..In this study, the processing and degradation of matrilin-4 during cartilage remodeling in the growth plate of the developing mouse long bones were studied in greater detail...
  8. Dy P, Wang W, Bhattaram P, Wang Q, Wang L, Ballock R, et al. Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell. 2012;22:597-609 pubmed publisher
    The transcription factor Sox9 is necessary for early chondrogenesis, but its subsequent roles in the cartilage growth plate, a highly specialized structure that drives skeletal growth and endochondral ossification, remain unclear...
  9. Plumb D, Ferrara L, Torbica T, Knowles L, Mironov A, Kadler K, et al. Collagen XXVII organises the pericellular matrix in the growth plate. PLoS ONE. 2011;6:e29422 pubmed publisher
    ..in the collagenous domain were phenotypically normal when heterozygote and displayed a mild disruption of growth plate architecture in the homozygous state...
  10. Ascenzi M, Blanco C, Drayer I, Kim H, Wilson R, Retting K, et al. Effect of localization, length and orientation of chondrocytic primary cilium on murine growth plate organization. J Theor Biol. 2011;285:147-55 pubmed publisher
    The research investigates the role of the immotile chondrocytic primary cilium in the growth plate. This study was motivated by (i) the recent evidence of the mechano-sensorial function of the primary cilium in kidney tubule epithelial ..
  11. Seriwatanachai D, Densmore M, Sato T, Correa D, Neff L, Baron R, et al. Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia. FASEB J. 2011;25:3057-67 pubmed publisher
    ..loss of Zfp521 from chondrocytes leads to reduced cell proliferation and increased differentiation in the growth plate. Thus, we hypothesized that specifically ablating Zfp521 from Jansen chondrocytes could sufficiently rescue the ..
  12. George J, Nagendran J, Azmi K. Comparison study of growth plate fusion using MRI versus plain radiographs as used in age determination for exclusion of overaged football players. Br J Sports Med. 2012;46:273-8 pubmed publisher
    ..Developing countries that cannot afford to perform MRI on their players are using plain radiographs based on the same MRI criteria of fusion...
  13. Musumeci G, Castrogiovanni P, Loreto C, Castorina S, Pichler K, Weinberg A. Post-traumatic caspase-3 expression in the adjacent areas of growth plate injury site: a morphological study. Int J Mol Sci. 2013;14:15767-84 pubmed publisher
    ..The objective of this study was to determine the impact of an injury in the growth plate chondrocytes through the study of histological morphology, immunohistochemistry, histomorphometry and Western ..
  14. Elbaradie K, Wang Y, Boyan B, Schwartz Z. Rapid membrane responses to dihydrotestosterone are sex dependent in growth plate chondrocytes. J Steroid Biochem Mol Biol. 2012;132:15-23 pubmed publisher
    ..Whereas female rat growth plate chondrocytes convert testosterone to 17?-estradiol, male chondrocytes produce 5?-dihydrotestosterone (DHT)...
  15. Li X, Wang S, Jiang L, Dai L. Gender- and region-specific variations of estrogen receptor ? and ? expression in the growth plate of spine and limb during development and adulthood. Histochem Cell Biol. 2012;137:79-95 pubmed publisher
    ..Mainly nuclear staining of ER? and ? immunoreactivity was demonstrated in the spinal and tibial growth plate chondrocytes for both genders...
  16. Lui J, Baron J. Effects of glucocorticoids on the growth plate. Endocr Dev. 2011;20:187-93 pubmed publisher
    Glucocorticoids have a direct, inhibitory effect on the growth plate, as demonstrated by in vivo and organ culture studies...
  17. de Andrea C, Prins F, Wiweger M, Hogendoorn P. Growth plate regulation and osteochondroma formation: insights from tracing proteoglycans in zebrafish models and human cartilage. J Pathol. 2011;224:160-8 pubmed publisher
    ..Human growth plate, wild-type zebrafish and fish mutants with mild proteoglycan defects (hi307 and kny) displayed proteoglycans ..
  18. Börjesson A, Windahl S, Karimian E, Eriksson E, Lagerquist M, Engdahl C, et al. The role of estrogen receptor-? and its activation function-1 for growth plate closure in female mice. Am J Physiol Endocrinol Metab. 2012;302:E1381-9 pubmed publisher
    High estradiol levels in late puberty induce growth plate closure and thereby cessation of growth in humans...
  19. Shao Y, Wang L, Welter J, Ballock R. Primary cilia modulate Ihh signal transduction in response to hydrostatic loading of growth plate chondrocytes. Bone. 2012;50:79-84 pubmed publisher
    ..is a key component of the regulatory apparatus governing chondrocyte proliferation and differentiation in the growth plate. Recent studies have demonstrated that the primary cilium is the site of Ihh signaling within the cell, and ..
  20. Jelinek E, Bittersohl B, Martiny F, Scharfstädt A, Krauspe R, Westhoff B. The 8-plate versus physeal stapling for temporary hemiepiphyseodesis correcting genu valgum and genu varum: a retrospective analysis of thirty five patients. Int Orthop. 2012;36:599-605 pubmed publisher
    ..The purpose of this study was to compare physeal stapling with 8-plate hemi-epiphyseodesis. We focused on evaluating deformity correction, complication rate and duration of the procedures...
  21. Emons J, Chagin A, Savendahl L, Karperien M, Wit J. Mechanisms of growth plate maturation and epiphyseal fusion. Horm Res Paediatr. 2011;75:383-91 pubmed publisher
    Longitudinal growth occurs within the long bones at the growth plate. During childhood, the growth plate matures, its total width decreases and eventually it disappears at the end of puberty with complete replacement by bone along with ..
  22. Narváez Tovar C, Garzón Alvarado D. Computational modeling of the mechanical modulation of the growth plate by sustained loading. Theor Biol Med Model. 2012;9:41 pubmed publisher
    ..that describes the growth of the bone as a function of the proliferation and hypertrophy of chondrocytes in the growth plate. We have included the effects of the mechanical loads on the sizes of the proliferative and hypertrophic areas, ..
  23. Farquharson C, Ahmed S. Inflammation and linear bone growth: the inhibitory role of SOCS2 on GH/IGF-1 signaling. Pediatr Nephrol. 2013;28:547-56 pubmed publisher
    ..Therefore, in this review, we will focus on the premise that SOCS2 signaling represents a critical pathway in growth plate chondrocytes through which pro-inflammatory cytokines alter both GH/IGF-1 signaling and cellular function.
  24. Seto J, Busse B, Gupta H, Schafer C, Krauss S, Dunlop J, et al. Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice. PLoS ONE. 2012;7:e47338 pubmed publisher
    ..deficient long bones, corroborating its physiological role as an inhibitor of excessive mineralization in the growth plate cartilage matrix--a site of vigorous physiological mineralization...
  25. Fernandez Vojvodich P, Palmblad K, Karimian E, Andersson U, Savendahl L. Pro-inflammatory cytokines produced by growth plate chondrocytes may act locally to modulate longitudinal bone growth. Horm Res Paediatr. 2012;77:180-7 pubmed publisher
    ..So far no role of these cytokines in modulation of normal bone growth has been established...
  26. Michigami T. Regulatory mechanisms for the development of growth plate cartilage. Cell Mol Life Sci. 2013;70:4213-21 pubmed publisher
    ..This review provides an overview of our current understanding of the regulators for the development of growth plate cartilage and their molecular mechanisms of action...
  27. Suleman F, Gualeni B, Gregson H, Leighton M, Piróg K, Edwards S, et al. A novel form of chondrocyte stress is triggered by a COMP mutation causing pseudoachondroplasia. Hum Mutat. 2012;33:218-31 pubmed publisher
    ..Overall, these data suggest that a novel form of chondrocyte stress triggered by the expression of mutant COMP is central to the pathogenesis of PSACH...
  28. Gao L, Sheu T, Dong Y, Hoak D, Zuscik M, Schwarz E, et al. TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci. 2013;126:5704-13 pubmed publisher
    ..These novel findings establish that TAK1 contributes to BMP2-mediated Sox9 gene expression and is essential for the postnatal development of normal growth plate and articular cartilages.
  29. Laurita J, Koyama E, Chin B, Taylor J, Lakin G, Hankenson K, et al. The Muenke syndrome mutation (FgfR3P244R) causes cranial base shortening associated with growth plate dysfunction and premature perichondrial ossification in murine basicranial synchondroses. Dev Dyn. 2011;240:2584-96 pubmed publisher
    ..the Muenke syndrome (FgfR3(P244R)) display postnatal shortening of the cranial base along with synchondrosis growth plate dysfunction characterized by loss of resting, proliferating and hypertrophic chondrocyte zones and decreased ..
  30. Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, et al. BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci. 2011;124:3428-40 pubmed publisher
    ..To investigate the specific function of the Bmp2 and Bmp4 genes in growth plate chondrocytes during cartilage development, we generated chondrocyte-specific Bmp2 and Bmp4 conditional knockout ..
  31. Pichler K, Musumeci G, Vielgut I, Martinelli E, Sadoghi P, Loreto C, et al. Towards a better understanding of bone bridge formation in the growth plate - an immunohistochemical approach. Connect Tissue Res. 2013;54:408-15 pubmed publisher
    The growth plate at the end of long bones is the cartilaginous organ responsible for longitudinal bone growth in children. Trauma to the growth plate, i.e...
  32. Chang C, Serra R. Ift88 regulates Hedgehog signaling, Sfrp5 expression, and ?-catenin activity in post-natal growth plate. J Orthop Res. 2013;31:350-6 pubmed publisher
    ..depletion of primary cilia from chondrocytes resulted in disorganized columnar structure and early loss of growth plate. To understand underlying mechanisms whereby Ift88 regulates growth plate function, we compared gene expression ..
  33. Emons J, Dutilh B, Decker E, Pirzer H, Sticht C, Gretz N, et al. Genome-wide screening in human growth plates during puberty in one patient suggests a role for RUNX2 in epiphyseal maturation. J Endocrinol. 2011;209:245-54 pubmed publisher
    In late puberty, estrogen decelerates bone growth by stimulating growth plate maturation...
  34. Späth S, Andrade A, Chau M, Nilsson O. Local regulation of growth plate cartilage. Endocr Dev. 2011;21:12-22 pubmed publisher
    Elongation of bones primarily occurs by endochondral ossification at the growth plate. In the growth plate, stem-like cells in the resting zone differentiate into rapidly dividing chondrocytes in the proliferative zone and then terminally ..
  35. Piao J, Tsuji K, Ochi H, Iwata M, Koga D, Okawa A, et al. Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling. Sci Rep. 2013;3:3022 pubmed publisher
    ..Immunohistological evaluation of the tibial growth plate in Sirt6?/? mice exhibited impaired proliferation and differentiation of chondrocytes, reduced expression of ..
  36. Pichler K, Schmidt B, Fischerauer E, Rinner B, Dohr G, Leithner A, et al. Behaviour of human physeal chondro-progenitorcells in early growth plate injury response in vitro. Int Orthop. 2012;36:1961-6 pubmed publisher
    ..investigate the proliferation and differentiation behaviour of a defined cell population gained from the human growth plate, namely, chondro-progenitorcells (CPCs), in the initial inflammatory phase of growth plate injury response in ..
  37. Chung R, Foster B, Xian C. Injury responses and repair mechanisms of the injured growth plate. Front Biosci (Schol Ed). 2011;3:117-25 pubmed
    The growth plate is responsible for longitudinal growth of children's long bones...
  38. Jones K. Glycobiology and the growth plate: current concepts in multiple hereditary exostoses. J Pediatr Orthop. 2011;31:577-86 pubmed publisher
    ..Understanding of its biological underpinnings has been advanced on a variety of fronts in recent years...
  39. Wu S, Levenson A, Kharitonenkov A, De Luca F. Fibroblast growth factor 21 (FGF21) inhibits chondrocyte function and growth hormone action directly at the growth plate. J Biol Chem. 2012;287:26060-7 pubmed publisher
    ..In light of the inhibitory effects on growth plate chondrogenesis mediated by other FGFs, we hypothesized that FGF21 causes growth inhibition by acting directly ..
  40. Eriksson E, Zaman F, Chrysis D, Wehtje H, Heino T, Savendahl L. Bortezomib is cytotoxic to the human growth plate and permanently impairs bone growth in young mice. PLoS ONE. 2012;7:e50523 pubmed publisher
    ..effects of bortezomib in vivo in young mice and in vitro in organ cultures of rat metatarsal bones and human growth plate cartilage, as well as in a rat chondrocytic cell line...
  41. Macsai C, Hopwood B, Chung R, Foster B, Xian C. Structural and molecular analyses of bone bridge formation within the growth plate injury site and cartilage degeneration at the adjacent uninjured area. Bone. 2011;49:904-12 pubmed publisher
    Injury to the growth plate is common and yet the injured cartilage is often repaired with undesirable bony tissue, leading to bone growth defects in children...
  42. Börjesson A, Lagerquist M, Windahl S, Ohlsson C. The role of estrogen receptor ? in the regulation of bone and growth plate cartilage. Cell Mol Life Sci. 2013;70:4023-37 pubmed publisher
    ..mechanisms, in vivo, mediated by the ER? activation functions (AFs), AF-1 and AF-2, and the effect on bone, growth plate and other estrogen responsive tissues...
  43. Macsai C, Georgiou K, Foster B, Zannettino A, Xian C. Microarray expression analysis of genes and pathways involved in growth plate cartilage injury responses and bony repair. Bone. 2012;50:1081-91 pubmed publisher
    The injured growth plate cartilage is often repaired by a bone bridge which causes bone growth deformities...
  44. Yang L, Lawson K, Teteak C, Zou J, Hacquebord J, Patterson D, et al. ESET histone methyltransferase is essential to hypertrophic differentiation of growth plate chondrocytes and formation of epiphyseal plates. Dev Biol. 2013;380:99-110 pubmed publisher
    ..Together, these results provide clear evidence that ESET controls hypertrophic differentiation of growth plate chondrocytes and endochondral ossification during embryogenesis and postnatal development.
  45. Stempel J, Fritsch H, Pfaller K, Blumer M. Development of articular cartilage and the metaphyseal growth plate: the localization of TRAP cells, VEGF, and endostatin. J Anat. 2011;218:608-18 pubmed publisher
    ..Subsequently, we examined the metaphyseal growth plate that is closed when skeletal maturity is attained...
  46. Zhong Z, Li T, Xu Z, Meng T, Zeng J, Zheng S, et al. Effect of melatonin on the proliferation and differentiation of chondrocytes from rat vertebral body growth plate in vitro. Int J Med Sci. 2013;10:1392-8 pubmed publisher
    Abnormal growth of vertebral body growth plate (VBGP) is considered as one of the etiologic factors in the adolescent idiopathic scoliosis (AIS). It was well-known that melatonin was correlated with the emergence and development of AIS...
  47. Li Y, Ahrens M, Wu A, Liu J, Dudley A. Calcium/calmodulin-dependent protein kinase II activity regulates the proliferative potential of growth plate chondrocytes. Development. 2011;138:359-70 pubmed publisher
    ..In the growth plate cartilage, this balance is achieved in part by establishing a proliferative phase that amplifies the number of ..
  48. Zaman F, Chrysis D, Huntjens K, Fadeel B, Savendahl L. Ablation of the pro-apoptotic protein Bax protects mice from glucocorticoid-induced bone growth impairment. PLoS ONE. 2012;7:e33168 pubmed publisher
    ..We and others have previously shown that glucocorticoids induce apoptosis in growth plate chondrocytes...
  49. Staines K, Mackenzie N, Clarkin C, Zelenchuk L, Rowe P, MacRae V, et al. MEPE is a novel regulator of growth plate cartilage mineralization. Bone. 2012;51:418-30 pubmed publisher
    ..of MEPE-overexpressing mice display severe morphological disruption, the expression and function of MEPE in growth plate matrix mineralization remains largely undefined...
  50. Randall R, Shao Y, Wang L, Ballock R. Activation of Wnt Planar Cell Polarity (PCP) signaling promotes growth plate column formation in vitro. J Orthop Res. 2012;30:1906-14 pubmed publisher
    Disrupting the Wnt Planar Cell Polarity (PCP) signaling pathway in vivo results in loss of columnar growth plate architecture, but it is unknown whether activation of this pathway in vitro is sufficient to promote column formation...
  51. Wosu R, Sergerie K, Levesque M, Villemure I. Mechanical properties of the porcine growth plate vary with developmental stage. Biomech Model Mechanobiol. 2012;11:303-12 pubmed publisher
    The objectives of this study were to extract the intrinsic mechanical properties of the growth plate at four different stages of growth and to compare two different methods of extracting these properties...
  52. Pando R, Even Zohar N, Shtaif B, Edry L, Shomron N, Phillip M, et al. MicroRNAs in the growth plate are responsive to nutritional cues: association between miR-140 and SIRT1. J Nutr Biochem. 2012;23:1474-81 pubmed publisher
    ..miRNAs in food-restriction-induced growth attenuation and nutrition-induced catch-up growth in the epiphyseal growth plate (EGP)...
  53. Wang Y, Cheng Z, Elalieh H, Nakamura E, Nguyen M, Mackem S, et al. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res. 2011;26:1437-46 pubmed publisher
    ..Our data indicate that the IGF-1R in chondrocytes controls cell growth, survival, and differentiation in embryonic and postnatal GPs in part by suppression of Pthrp expression...
  54. Leung V, Gao B, Leung K, Melhado I, Wynn S, Au T, et al. SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genet. 2011;7:e1002356 pubmed publisher
    ..Discrimination between these opposing modes of transcriptional control by SOX9 may be mediated by cooperation with different partners such as GLI factors...
  55. Wang L, Shao Y, Ballock R. Leptin synergizes with thyroid hormone signaling in promoting growth plate chondrocyte proliferation and terminal differentiation in vitro. Bone. 2011;48:1022-7 pubmed publisher
    ..leptin-deficient ob/ob mice indicate that leptin also has peripheral effects in modulating the function of the growth plate, perhaps in terms of proliferation and differentiation enhancement...
  56. Lui J, Nilsson O, Baron J. Growth plate senescence and catch-up growth. Endocr Dev. 2011;21:23-9 pubmed publisher
    ..proliferation, and is associated with other structural, functional, and molecular changes collectively termed growth plate senescence...
  57. Lui J, Nilsson O, Chan Y, Palmer C, Andrade A, Hirschhorn J, et al. Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height. Hum Mol Genet. 2012;21:5193-201 pubmed publisher
    ..of the causative genes within these loci influence height because they are expressed in and function in the growth plate, a cartilaginous structure that causes bone elongation and thus determines stature...
  58. Petit A, Demers C, Girard Lauriault P, Stachura D, Wertheimer M, Antoniou J, et al. Effect of nitrogen-rich cell culture surfaces on type X collagen expression by bovine growth plate chondrocytes. Biomed Eng Online. 2011;10:4 pubmed publisher
    ..of n...
  59. Sun H, Zang W, Zhou B, Xu L, Wu S. DHEA suppresses longitudinal bone growth by acting directly at growth plate through estrogen receptors. Endocrinology. 2011;152:1423-33 pubmed publisher
    ..is unclear whether DHEA can affect longitudinal bone growth and skeletal maturation by acting directly at the growth plate. In our study, DHEA suppressed metatarsal growth, growth plate chondrocyte proliferation, and hypertrophy/..
  60. Rasaputra K, Liyanage A, Lay J, McCarthy F, Rath N. Tibial dyschondroplasia-associated proteomic changes in chicken growth plate cartilage. Avian Dis. 2010;54:1166-71 pubmed
    Tibial dyschondroplasia (TD) is a poultry leg problem that affects the proximal growth plate of the tibia, preventing its transition to bone...
  61. Hsu S, Zhang X, Yu C, Li Z, Wunder J, Hui C, et al. Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu. Development. 2011;138:3791-801 pubmed publisher
    ..regulation of Indian hedgehog (Ihh) signaling is vital for chondrocyte proliferation and differentiation in the growth plate. Its dysregulation causes skeletal dysplasia, osteoarthritis or cartilaginous neoplasia...
  62. Kuss P, Kraft K, Stumm J, Ibrahim D, Vallecillo García P, Mundlos S, et al. Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014;385:83-93 pubmed publisher
    ..This study provides a so far unrecognized link between HOX proteins and cell polarity in the perichondrium and the growth plate, a failure of which leads to transformation of metacarpals to carpal-like structures.