epiphyses

Summary

Summary: The head of a long bone that is separated from the shaft by the epiphyseal plate until bone growth stops. At that time, the plate disappears and the head and shaft are united.

Top Publications

  1. Davis D, Chen L, Young S. Evaluation of epiphyses in the skeletally immature knee using magnetic resonance imaging: a pilot study to analyze parameters for anterior cruciate ligament reconstruction. Am J Sports Med. 2013;41:1579-85 pubmed publisher
    ..However, normal values for this parameter have yet to be established on cross-sectional magnetic resonance imaging (MRI)...
  2. Reis A, Kannengiesser C, Jennane F, Manna T, Cheurfa N, Oudin C, et al. Two novel mutations in the EIF2AK3 gene in children with Wolcott-Rallison syndrome. Pediatr Diabetes. 2011;12:187-91 pubmed publisher
    ..The clinical phenotype associated with the syndrome can be variable, but a combination of infancy-onset diabetes mellitus, multiple epiphyseal dysplasia, and hepatic and/or renal dysfunction is the mainstay of diagnosis...
  3. Garamendi P, Landa M, Botella M, Alemán I. Forensic age estimation on digital X-ray images: Medial epiphyses of the clavicle and first rib ossification in relation to chronological age. J Forensic Sci. 2011;56 Suppl 1:S3-12 pubmed publisher
    ..Scoring for fusion of medial epiphyses of the clavicle was carried out by Schmeling's system and ossification of the costal cartilage of the first rib ..
  4. Lee E, Lamplugh L, Kluczyk B, Leblond C, Mort J. Neoepitopes reveal the features of type II collagen cleavage and the identity of a collagenase involved in the transformation of the epiphyses anlagen in development. Dev Dyn. 2009;238:1547-63 pubmed publisher
    ..The collective findings reveal that COL2 is attacked at the afore-described susceptible peptide bond at the surface of cartilage canals and, that MMP-13 cleaves it. Developmental Dynamics 238:1547-1563, 2009. (c) 2009 Wiley-Liss, Inc...
  5. Rios L, Cardoso H. Age estimation from stages of union of the vertebral epiphyses of the ribs. Am J Phys Anthropol. 2009;140:265-74 pubmed publisher
    ..No directional asymmetry was found, but a significant fluctuating asymmetry was observed in all three epiphyses. A preliminary analysis showed that the asymmetric group of individuals in the study sample includes all the ..
  6. Le Guehennec L, Goyenvalle E, Lopez Heredia M, Weiss P, Amouriq Y, Layrolle P. Histomorphometric analysis of the osseointegration of four different implant surfaces in the femoral epiphyses of rabbits. Clin Oral Implants Res. 2008;19:1103-10 pubmed publisher
    The surface properties of titanium dental implants are key parameters for rapid and intimate bone-implant contact. The osseointegration of four implant surfaces was studied in the femoral epiphyses of rabbits.
  7. Allerstorfer D, Longato S, Schwarzer C, Fischer Colbrie R, Hayman A, Blumer M. VEGF and its role in the early development of the long bone epiphysis. J Anat. 2010;216:611-24 pubmed publisher
    ..Secretoneurin, however, does not appear to be a player in this event. Hypertrophic chondrocytes undergo cell death by a mechanism interpreted as chondroptosis...
  8. Søvik O, Njølstad P, Jellum E, Molven A. Wolcott-Rallison syndrome with 3-hydroxydicarboxylic aciduria and lethal outcome. J Inherit Metab Dis. 2008;31 Suppl 2:S293-7 pubmed publisher
    ..1694_1695delAT (Y565X) and c.3044T?>?C (F1015S). Our data suggest that disruption of the EIF2AK3 gene may lead to defective mitochondrial fatty acid oxidation and hypoglycaemia, thus adding to the heterogeneous phenotype of WRS...
  9. Ozbek M, Senée V, Aydemir S, Kotan L, Mungan N, Yuksel B, et al. Wolcott-Rallison syndrome due to the same mutation (W522X) in EIF2AK3 in two unrelated families and review of the literature. Pediatr Diabetes. 2010;11:279-85 pubmed publisher
    ..Other than the consistent features of diabetes mellitus and epiphyseal dysplasia, WRS patients are otherwise characterized by extensive phenotypic variability that correlates poorly to genotype...

Scientific Experts

More Information

Publications62

  1. Ozbey O, Sahin Z, Acar N, Ustunel I. Distribution of CD105 and CD166 positive cells in the proximal epiphysis of developing rat humerus. Histol Histopathol. 2010;25:1437-45 pubmed publisher
  2. Julier C, Nicolino M. Wolcott-Rallison syndrome. Orphanet J Rare Dis. 2010;5:29 pubmed publisher
    ..Prognosis is poor and most patients die at a young age. Intervention strategies targeting ER dysfunction provide hope for future therapy and prevention...
  3. Feng D, Meng Y, Zhao S, Shi H, Wang W, Huang S. [Two novel EIF2AK3 mutations in a Chinese boy with Wolcott-Rallison syndrome]. Zhonghua Er Ke Za Zhi. 2011;49:301-5 pubmed
    ..Here we describe a Chinese boy affected by WRS. Genetic testing of his EIF2AK3 gene was performed in order to elucidate molecular variations and subsequently to provide credible genetic counseling for prenatal diagnosis in his family...
  4. Sang Y, Liu M, Yang W, Yan J, Chengzhu -, Ni G. A novel EIF2AK3 mutation leading to Wolcott-Rallison syndrome in a Chinese child. J Pediatr Endocrinol Metab. 2011;24:181-4 pubmed
    ..In the present study, we analyzed the EIF2AK3 gene in a 10-year-old WRS patient and his parents to study the clinical features and the mechanism for genetic onset of WRS...
  5. Mihci E, Türkkahraman D, Ellard S, Akçurin S, Bircan I. Wolcott-Rallison syndrome due to a novel mutation (R491X) in EIF2AK3 gene. J Clin Res Pediatr Endocrinol. 2012;4:101-3 pubmed publisher
    ..This patient demonstrates that the other findings of this syndrome might be obscured by a diagnosis of isolated neonatal diabetes. ..
  6. Chung S. The arterial supply of the developing proximal end of the human femur. J Bone Joint Surg Am. 1976;58:961-70 pubmed
    ..This finding may be important for the etiology of Legg-Perthes disease. No differences with respect to age, sex, or race were found in the arteries of the ligamentum teres...
  7. Schaefer M, Black S. Comparison of ages of epiphyseal union in North American and Bosnian skeletal material. J Forensic Sci. 2005;50:777-84 pubmed
    ..Of the ten epiphyses considered in this study, all elements were observed to be at least two years in advance in the Bosnian sample ..
  8. Schulz R, Mühler M, Mutze S, Schmidt S, Reisinger W, Schmeling A. Studies on the time frame for ossification of the medial epiphysis of the clavicle as revealed by CT scans. Int J Legal Med. 2005;119:142-5 pubmed
    ..The question of how slice thickness affects the age intervals between ossification stages identified by CT examinations should be examined in additional studies...
  9. Botter S, van Osch G, Waarsing J, Day J, Verhaar J, Pols H, et al. Quantification of subchondral bone changes in a murine osteoarthritis model using micro-CT. Biorheology. 2006;43:379-88 pubmed
    ..In conclusion, four weeks after induction of osteoarthritis in the murine knee subtle but significant changes in subchondral bone architecture could be detected and quantified in 3D with micro-CT analysis...
  10. Boss J, Misselevich I, Peskin B, Zinman C, Levin D, Norman D, et al. Postosteonecrotic osteoarthritis-like disorder of the femoral head of rats. J Comp Pathol. 2003;129:235-9 pubmed
    ..The epiphyses consisted of immature disorganized subchondral and trabecular bone...
  11. Bin Abbas B, Al Mulhim A, Al Ashwal A. Wolcott-Rallison syndrome in two siblings with isolated central hypothyroidism. Am J Med Genet. 2002;111:187-90 pubmed
    ..In both of our cases we found evidence of central hypothyroidism, which appears to be an associated feature of this syndrome. Hypothyroidism should be suspected and screened for in all cases of Wolcott-Rallison syndrome...
  12. Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop G, Julier C. EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nat Genet. 2000;25:406-9 pubmed
    ..Our results provide evidence for the role of EIF2AK3 in WRS. The identification of this gene may provide insight into the understanding of the more common forms of diabetes and other pathologic manifestations of WRS...
  13. Blumer M, Longato S, Schwarzer C, Fritsch H. Bone development in the femoral epiphysis of mice: the role of cartilage canals and the fate of resting chondrocytes. Dev Dyn. 2007;236:2077-88 pubmed
    ..Several resting chondrocytes are assigned to die but others, after freeing into the canal cavity, may differentiate into osteoblasts...
  14. Joseph B, Mulpuri K, Varghese G. Perthes' disease in the adolescent. J Bone Joint Surg Br. 2001;83:715-20 pubmed
    ..The poorest clinical results were found in the destructive type which was frequently associated with incapacitating pain requiring arthrodesis or excision arthroplasty within three years of onset of the disease...
  15. Davoli M, Lamplugh L, Beauchemin A, Chan K, Mordier S, Mort J, et al. Enzymes active in the areas undergoing cartilage resorption during the development of the secondary ossification center in the tibiae of rats aged 0-21 days: II. Two proteinases, gelatinase B and collagenase-3, are implicated in the lysis of collagen. Dev Dyn. 2001;222:71-88 pubmed
  16. Serrat M, Reno P, McCollum M, Meindl R, Lovejoy C. Variation in mammalian proximal femoral development: comparative analysis of two distinct ossification patterns. J Anat. 2007;210:249-58 pubmed
    ..As some osseous abnormalities of the human hip appear to mimic the normal morphology of species with coalesced epiphyses, these results may provide insight into the aetiology and treatment of human hip disorders such as ..
  17. Pietka E, Gertych A, Pospiech S, Cao F, Huang H, Gilsanz V. Computer-assisted bone age assessment: image preprocessing and epiphyseal/metaphyseal ROI extraction. IEEE Trans Med Imaging. 2001;20:715-29 pubmed
    ..Extracted features describe the stage of skeletal development more objectively than visual comparison...
  18. Lyon R, Liu X, Meier J. The effects of therapeutic vs. high-intensity ultrasound on the rabbit growth plate. J Orthop Res. 2003;21:865-71 pubmed
    ..05). This short-term study demonstrates that high dose ultrasound has profound pathologic effects in growing bone. Therapeutic doses of ultrasound do not have an adverse effect on bone growth in the short-term follow-up...
  19. Rothenberg A, Berdon W, Woodard J, Cowles R. Hypervitaminosis A-induced premature closure of epiphyses (physeal obliteration) in humans and calves (hyena disease): a historical review of the human and veterinary literature. Pediatr Radiol. 2007;37:1264-7 pubmed
    ..was recognized in the 1940s as painful periostitis with rare progression to premature closure of the lower limb epiphyses. Decades later, most cases of vitamin A-induced premature epiphyseal closure (physeal obliteration) occur in ..
  20. Bonthron D, Dunlop N, Barr D, El Sanousi A, al Gazali L. Organisation of the human PAX4 gene and its exclusion as a candidate for the Wolcott-Rallison syndrome. J Med Genet. 1998;35:288-92 pubmed
    ..It therefore appears unlikely that PAX4 is involved in the aetiology of Wolcott-Rallison syndrome, though it remains a good candidate for other forms of neonatal diabetes mellitus...
  21. Rivas R, Shapiro F. Structural stages in the development of the long bones and epiphyses: a study in the New Zealand white rabbit. J Bone Joint Surg Am. 2002;84-A:85-100 pubmed
    ..This report describes the sequence of histologic events involved in the formation of long bones and their epiphyses in the New Zealand White rabbit.
  22. Maes C, Stockmans I, Moermans K, Van Looveren R, Smets N, Carmeliet P, et al. Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J Clin Invest. 2004;113:188-99 pubmed
    ..These findings indicate that the insoluble VEGF(188) isoform is insufficient for establishing epiphyseal vascularization and regulating cartilage development during endochondral bone formation...
  23. Kim H, Randall T, Bian H, Jenkins J, Garces A, Bauss F. Ibandronate for prevention of femoral head deformity after ischemic necrosis of the capital femoral epiphysis in immature pigs. J Bone Joint Surg Am. 2005;87:550-7 pubmed
    ..The effect of ibandronate on long-bone growth was also assessed...
  24. Schulze D, Rother U, Fuhrmann A, Richel S, Faulmann G, Heiland M. Correlation of age and ossification of the medial clavicular epiphysis using computed tomography. Forensic Sci Int. 2006;158:184-9 pubmed
    ..The aim of this study was the examination of relationship between the age and the ossification of medial epiphysis of the clavicle referred to CT examination...
  25. Alvarez J, Costales L, Lopez Muñiz A, López J. Chondrocytes are released as viable cells during cartilage resorption associated with the formation of intrachondral canals in the rat tibial epiphysis. Cell Tissue Res. 2005;320:501-7 pubmed
    The development of cartilage canals is the first event of the ossification of the epiphyses in mammals...
  26. Alvarez J, Costales L, Serra R, Balbin M, López J. Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification. J Bone Miner Res. 2005;20:1011-21 pubmed
    ..MMPs were widely expressed during ossification of the secondary center, whereas expression of VEGF was restricted to later stages...
  27. Tayton K. Does the upper femoral epiphysis slip or rotate?. J Bone Joint Surg Br. 2007;89:1402-6 pubmed
    ..The presence and size of this peg-like tubercle was shown radiologically by CT scanning in one pair of intact adolescent femurs...
  28. Cheng C, Lian W, Hsiao F, Liu I, Lin S, Lee Y, et al. Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells. PLoS ONE. 2012;7:e36085 pubmed publisher
    ..The objective of this study was to find an alternative murine MSCs source that could provide sufficient MSCs...
  29. Gnassingbe K, Walla A, Akakpo Numado G, Ketevi A, Tekou H. [Epiphyseal growth fractures: epidemiology and treatment. Retrospective report of 44 cases]. Mali Med. 2011;26:1-3 pubmed
    ..To value the frequency of epiphyseal growth fracture and to take out the therapeutic aspects of the epiphyseal growth fracture and to value the results for un good management...
  30. Kashif M, Deserno T, Haak D, Jonas S. Feature description with SIFT, SURF, BRIEF, BRISK, or FREAK? A general question answered for bone age assessment. Comput Biol Med. 2016;68:67-75 pubmed publisher
    ..With a mean error of 0.605 years, dense SIFT gave best results and outperforms all published methods. The accuracy was 98.36% within the range of 2 years. Dense SIFT represents a generic method for a specific question. ..
  31. Kim H, Laor T, Shire N, Bean J, Dardzinski B. Anterior and posterior cruciate ligaments at different patient ages: MR imaging findings. Radiology. 2008;247:826-35 pubmed publisher
    ..To retrospectively compile normative data on the anterior cruciate ligament (ACL) and the posterior cruciate ligament (PCL) in children and young adults...
  32. Yao Y, Kang P, Li X, Yang J, Shen B, Zhou Z, et al. Study on the effect of T-2 toxin combined with low nutrition diet on rat epiphyseal plate growth and development. Int Orthop. 2010;34:1351-6 pubmed publisher
    ..T-2 toxin combined with a low nutrition diet could lead to more serious chondrocyte necrosis in the epiphyseal plate and disturb metaphyseal trabecular bone formation...
  33. Luo J, Tang J, Zhou L, Zeng R, Mou J, Zhang L. Femoral head epiphysis growth and development among Chinese children aged 0-5 years. Eur J Pediatr. 2009;168:545-51 pubmed publisher
  34. Jacobsen S, Hansson G, Nathorst Westfelt J. Traumatic separation of the distal epiphysis of the humerus sustained at birth. J Bone Joint Surg Br. 2009;91:797-802 pubmed publisher
    ..However, even when no attempt is made to reduce the displaced epiphysis, a good clinical result can be expected...
  35. Hwang J, Bae W, Shieu W, Lewis C, Bugbee W, Sah R. Increased hydraulic conductance of human articular cartilage and subchondral bone plate with progression of osteoarthritis. Arthritis Rheum. 2008;58:3831-42 pubmed publisher
    ..The study hypothesis was that hydraulic conductance of osteochondral tissue and subchondral bone plate increases with structural changes indicative of increasing stages of OA...
  36. Peinado Cortés L, Vanegas Acosta J, Garzón Alvarado D. A mechanobiological model of epiphysis structures formation. J Theor Biol. 2011;287:13-25 pubmed publisher
    ..Cartilage canal spatial-temporal growth patterns were obtained as well as the SOC formation pattern. This model qualitatively agreed with experimental results reported by other authors...
  37. Ayoub D, Hyman C, Cohen M, Miller M. A critical review of the classic metaphyseal lesion: traumatic or metabolic?. AJR Am J Roentgenol. 2014;202:185-96 pubmed publisher
    ..The purpose of this study was to review the hypothesis that classic metaphyseal lesions represent traumatic changes in abused infants and compare these lesions with healing rickets...
  38. Habeb A. Frequency and spectrum of Wolcott-Rallison syndrome in Saudi Arabia: a systematic review. Libyan J Med. 2013;8:21137 pubmed publisher
    ..Wolcott-Rallison syndrome (WRS) is caused by recessive EIF2AK3 gene mutations and characterized by permanent neonatal diabetes (PNDM), skeletal dysplasia, and recurrent hepatitis. The frequency of this rare syndrome is largely unknown...
  39. Liu K, Wang K, Yan H. Incomplete digestion preserves chondrocytes from dedifferentiating in long-termed culture on plastic substrate. Tissue Cell. 2009;41:1-11 pubmed publisher
    ..Especially, as extracellular matrix was preserved, chondrocytes expressed stable phenotype in a rather long-termed culture...
  40. Horvat Gordon M, Praul C, Ramachandran R, Bartell P, Leach R. Use of microarray analysis to study gene expression in the avian epiphyseal growth plate. Comp Biochem Physiol Part D Genomics Proteomics. 2010;5:12-23 pubmed publisher
    ..These processes are important to the physiology and survival of chondrocytes in the unique and stressful environment of the epiphyseal growth plate...
  41. De Filippo M, Pogliacomi F, Albisinni U, Quinto S, Bocchi C, Sverzellati N, et al. Occult large epiphyseal solitary plasmacytoma at multidetector row computer tomography detected by magnetic resonance imaging. Acta Biomed. 2008;79:240-5 pubmed
    ..The lesion was confirmed by PET and the histological diagnosis was performed by a CT guided bioptic sample...
  42. Ivanusic J. Size, neurochemistry, and segmental distribution of sensory neurons innervating the rat tibia. J Comp Neurol. 2009;517:276-83 pubmed publisher
    ..skin were observed. The findings of the present study show that the periosteum, medullary cavity, and trabecular bone are all innervated by sensory neurons that have size and neurochemical profiles consistent with a role in nociception...
  43. McCarthy J, Noonan K, Nemke B, Markel M. Guided growth of the proximal femur: a pilot study in the lamb model. J Pediatr Orthop. 2010;30:690-4 pubmed publisher
    ..The purpose of this study is to determine whether guided growth techniques are effective at altering the morphology of the proximal femur in a lamb model...
  44. Yoo W, Kim Y, Menezes N, Cheon J, Jaramillo D. Diffusion-weighted MRI reveals epiphyseal and metaphyseal abnormalities in Legg-Calvé-Perthes disease: a pilot study. Clin Orthop Relat Res. 2011;469:2881-8 pubmed publisher
    ..Legg-Calvé-Perthes disease (LCP) is thought to be associated with ischemic events in the femoral head. However, the types and patterns of reperfusion after these ischemic events are unclear...
  45. Schoeniger R, Espinosa N, Sierra R, Leunig M, Ganz R. Role of the extraosseus blood supply in osteoarthritic femoral heads?. Clin Orthop Relat Res. 2009;467:2235-40 pubmed publisher
    ..We recommend the use of a safe surgical approach for hip resurfacing and careful implantation of the femoral component to respect blood supply to the femoral head and neck region in hip resurfacing arthroplasty...
  46. Eckert K, Ackermann O, Schweiger B, Radeloff E, Liedgens P. Sonographic diagnosis of metaphyseal forearm fractures in children: a safe and applicable alternative to standard x-rays. Pediatr Emerg Care. 2012;28:851-4 pubmed publisher
    ..Radiography of the wrist is the standard diagnostic procedure. The aim of our study was to evaluate and confirm the safety and applicability of the ultrasound diagnostic procedure in comparison to x-ray diagnosis...
  47. Haddad F, Chemali R, Maalouf G. Dysplasia epiphysealis hemimelica with involvement of the hip and spine in a young girl. J Bone Joint Surg Br. 2008;90:952-6 pubmed publisher
    ..To the authors' knowledge, this is the first report of dysplasia epiphysealis hemimelica involving both the lower limb and the spine. A review of the literature is presented...
  48. Cluzel C, Blond L, Fontaine P, Olive J, Laverty S. Foetal and postnatal equine articular cartilage development: magnetic resonance imaging and polarised light microscopy. Eur Cell Mater. 2013;26:33-47; discussion 47-8 pubmed
    ..T2-weighted fast-spin echo (FSE) sequences and PLM assessment were performed on distal femoral epiphyses of equine foetuses, foals and adults...
  49. Murgier J, Reina N, Cavaignac E, Espie A, Bayle Iniguez X, Chiron P. The frequency of sequelae of slipped upper femoral epiphysis in cam-type femoroacetabular impingement. Bone Joint J. 2014;96-B:724-9 pubmed publisher
    ..001). The impingement group had a mean ? angle of 73.9° (96.2° to 53.4°) versus 48.2° (65° to 37°) in the control group (p < 0.001). Our results suggest that SUFE is one of the primary aetiological factors for cam-type FAI...
  50. Venkatesh C, Adhisivam B. Natal teeth in an infant with congenital hypothyroidism. Indian J Dent Res. 2011;22:498 pubmed publisher
    ..However, they may be associated with genetic syndromes like Ellis Van Creveld syndrome and Hallermann-Streiff syndrome. We report here a case of natal teeth in an infant with congenital hypothyroidism...
  51. Kampschulte M, Krombach G, Richards D, Sender J, Lips K, Thormann U, et al. Neovascularization of osteoporotic metaphyseal bone defects: A morphometric micro-CT study. Microvasc Res. 2016;105:7-14 pubmed publisher
    ..As angiogenesis is a crucial prerequisite that precedes osteogenesis, our results may influence further evaluation of osteoconductive or osteogenic biomaterials in this small animal model of osteoporosis. ..
  52. Joo S, Oh C, Grissom L, Kumar S, MacEwen G. Three-dimensional computerized tomographic analysis of the deformity of lateral growth disturbance of proximal femoral physis. J Pediatr Orthop. 2009;29:540-6 pubmed publisher
    ..The purpose of this study was to define the anatomy of the proximal femur after the lateral growth disturbance of the proximal femoral physis with 3D CT scans...
  53. Ladd P, Laor T, Emery K, Salisbury S, Parikh S. Medial collateral ligament of the knee on magnetic resonance imaging: does the site of the femoral origin change at different patient ages in children and young adults?. J Pediatr Orthop. 2010;30:224-30 pubmed publisher